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Compile Data Set for Download or QSAR

Found 35 hits of ic50 for UniProtKB: A0A024R0C8   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Rho-related GTP-binding protein RhoC


(Homo sapiens)
BDBM50481356
PNG
(CCG-1423 | CHEMBL595382)
Show SMILES CC(ONC(=O)c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C(O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C18H15ClF6N2O3/c1-9(15(28)26-14-4-2-13(19)3-5-14)30-27-16(29)10-6-11(17(20,21)22)8-12(7-10)18(23,24)25/h2-9,15,26,28H,1H3,(H,27,29)
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n/an/a 1.50E+3n/an/an/an/an/an/a



University of Michigan Medical School

Curated by ChEMBL


Assay Description
Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay


Bioorg Med Chem Lett 20: 665-72 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.056
BindingDB Entry DOI: 10.7270/Q29S1TTD
More data for this
Ligand-Target Pair
Rho-related GTP-binding protein RhoC


(Homo sapiens)
BDBM50481362
PNG
(CHEMBL591786)
Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1cccc(c1)C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C22H13ClF6N2O2/c23-16-4-6-17(7-5-16)30-19(32)12-2-1-3-18(10-12)31-20(33)13-8-14(21(24,25)26)11-15(9-13)22(27,28)29/h1-11H,(H,30,32)(H,31,33)
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n/an/a 1.70E+3n/an/an/an/an/an/a



University of Michigan Medical School

Curated by ChEMBL


Assay Description
Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay


Bioorg Med Chem Lett 20: 665-72 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.056
BindingDB Entry DOI: 10.7270/Q29S1TTD
More data for this
Ligand-Target Pair
Rho-related GTP-binding protein RhoC


(Homo sapiens)
BDBM50481364
PNG
(CHEMBL606913)
Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)NCc1csc(n1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C19H11ClF6N2OS/c20-14-3-1-10(2-4-14)17-28-15(9-30-17)8-27-16(29)11-5-12(18(21,22)23)7-13(6-11)19(24,25)26/h1-7,9H,8H2,(H,27,29)
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n/an/a 4.10E+3n/an/an/an/an/an/a



University of Michigan Medical School

Curated by ChEMBL


Assay Description
Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay


Bioorg Med Chem Lett 20: 665-72 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.056
BindingDB Entry DOI: 10.7270/Q29S1TTD
More data for this
Ligand-Target Pair
Rho-related GTP-binding protein RhoC


(Homo sapiens)
BDBM50481352
PNG
(CHEMBL589372)
Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C1=NOC(CC(=O)Nc2ccc(Cl)cc2)C1
Show InChI InChI=1S/C19H13ClF6N2O2/c20-13-1-3-14(4-2-13)27-17(29)9-15-8-16(28-30-15)10-5-11(18(21,22)23)7-12(6-10)19(24,25)26/h1-7,15H,8-9H2,(H,27,29)
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n/an/a 4.20E+3n/an/an/an/an/an/a



University of Michigan Medical School

Curated by ChEMBL


Assay Description
Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay


Bioorg Med Chem Lett 20: 665-72 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.056
BindingDB Entry DOI: 10.7270/Q29S1TTD
More data for this
Ligand-Target Pair
Transforming protein RhoA/Rho-related GTP-binding protein RhoC


(Homo sapiens (Human))
BDBM50481337
PNG
(CHEMBL594911)
Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)NOCC(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C17H11ClF6N2O3/c18-12-1-3-13(4-2-12)25-14(27)8-29-26-15(28)9-5-10(16(19,20)21)7-11(6-9)17(22,23)24/h1-7H,8H2,(H,25,27)(H,26,28)
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n/an/a 4.70E+3n/an/an/an/an/an/a



University of Michigan Medical School

Curated by ChEMBL


Assay Description
Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay


Bioorg Med Chem Lett 20: 665-72 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.056
BindingDB Entry DOI: 10.7270/Q29S1TTD
More data for this
Ligand-Target Pair
Rho-related GTP-binding protein RhoC


(Homo sapiens)
BDBM50481343
PNG
(CHEMBL590596)
Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)NCCCNc1ccc(Cl)cc1
Show InChI InChI=1S/C18H15ClF6N2O/c19-14-2-4-15(5-3-14)26-6-1-7-27-16(28)11-8-12(17(20,21)22)10-13(9-11)18(23,24)25/h2-5,8-10,26H,1,6-7H2,(H,27,28)
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n/an/a 5.10E+3n/an/an/an/an/an/a



University of Michigan Medical School

Curated by ChEMBL


Assay Description
Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay


Bioorg Med Chem Lett 20: 665-72 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.056
BindingDB Entry DOI: 10.7270/Q29S1TTD
More data for this
Ligand-Target Pair
Rho-related GTP-binding protein RhoC


(Homo sapiens)
BDBM50481340
PNG
(CHEMBL591077)
Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)NOCC(=O)Nc1cccc(Cl)c1
Show InChI InChI=1S/C17H11ClF6N2O3/c18-12-2-1-3-13(7-12)25-14(27)8-29-26-15(28)9-4-10(16(19,20)21)6-11(5-9)17(22,23)24/h1-7H,8H2,(H,25,27)(H,26,28)
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n/an/a 5.90E+3n/an/an/an/an/an/a



University of Michigan Medical School

Curated by ChEMBL


Assay Description
Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay


Bioorg Med Chem Lett 20: 665-72 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.056
BindingDB Entry DOI: 10.7270/Q29S1TTD
More data for this
Ligand-Target Pair
Rho-related GTP-binding protein RhoC


(Homo sapiens)
BDBM50481344
PNG
(CHEMBL591549)
Show SMILES FC(F)(F)c1cc(CNCCC(=O)Nc2ccc(Cl)cc2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C18H15ClF6N2O/c19-14-1-3-15(4-2-14)27-16(28)5-6-26-10-11-7-12(17(20,21)22)9-13(8-11)18(23,24)25/h1-4,7-9,26H,5-6,10H2,(H,27,28)
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n/an/a 8.10E+3n/an/an/an/an/an/a



University of Michigan Medical School

Curated by ChEMBL


Assay Description
Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay


Bioorg Med Chem Lett 20: 665-72 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.056
BindingDB Entry DOI: 10.7270/Q29S1TTD
More data for this
Ligand-Target Pair
Rho-related GTP-binding protein RhoC


(Homo sapiens)
BDBM50481359
PNG
(CHEMBL591080)
Show SMILES FC(F)(F)c1cc(NC(=O)CONC(=O)c2ccc(Cl)cc2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C17H11ClF6N2O3/c18-12-3-1-9(2-4-12)15(28)26-29-8-14(27)25-13-6-10(16(19,20)21)5-11(7-13)17(22,23)24/h1-7H,8H2,(H,25,27)(H,26,28)
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n/an/a 8.60E+3n/an/an/an/an/an/a



University of Michigan Medical School

Curated by ChEMBL


Assay Description
Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay


Bioorg Med Chem Lett 20: 665-72 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.056
BindingDB Entry DOI: 10.7270/Q29S1TTD
More data for this
Ligand-Target Pair
Rho-related GTP-binding protein RhoC


(Homo sapiens)
BDBM50481369
PNG
(CHEMBL592022)
Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)NCCCOc1ccc(Cl)cc1
Show InChI InChI=1S/C18H14ClF6NO2/c19-14-2-4-15(5-3-14)28-7-1-6-26-16(27)11-8-12(17(20,21)22)10-13(9-11)18(23,24)25/h2-5,8-10H,1,6-7H2,(H,26,27)
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n/an/a 8.90E+3n/an/an/an/an/an/a



University of Michigan Medical School

Curated by ChEMBL


Assay Description
Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay


Bioorg Med Chem Lett 20: 665-72 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.056
BindingDB Entry DOI: 10.7270/Q29S1TTD
More data for this
Ligand-Target Pair
Rho-related GTP-binding protein RhoC


(Homo sapiens)
BDBM50481360
PNG
(CHEMBL591550)
Show SMILES FC(F)(F)c1cc(CNCCCNc2ccc(Cl)cc2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C18H17ClF6N2/c19-15-2-4-16(5-3-15)27-7-1-6-26-11-12-8-13(17(20,21)22)10-14(9-12)18(23,24)25/h2-5,8-10,26-27H,1,6-7,11H2
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n/an/a 9.10E+3n/an/an/an/an/an/a



University of Michigan Medical School

Curated by ChEMBL


Assay Description
Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay


Bioorg Med Chem Lett 20: 665-72 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.056
BindingDB Entry DOI: 10.7270/Q29S1TTD
More data for this
Ligand-Target Pair
Rho-related GTP-binding protein RhoC


(Homo sapiens)
BDBM50481347
PNG
(CHEMBL591081)
Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)N1CCCCC1CC(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C22H19ClF6N2O2/c23-16-4-6-17(7-5-16)30-19(32)12-18-3-1-2-8-31(18)20(33)13-9-14(21(24,25)26)11-15(10-13)22(27,28)29/h4-7,9-11,18H,1-3,8,12H2,(H,30,32)
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n/an/a 9.50E+3n/an/an/an/an/an/a



University of Michigan Medical School

Curated by ChEMBL


Assay Description
Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay


Bioorg Med Chem Lett 20: 665-72 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.056
BindingDB Entry DOI: 10.7270/Q29S1TTD
More data for this
Ligand-Target Pair
Rho-related GTP-binding protein RhoC


(Homo sapiens)
BDBM50436237
PNG
(CHEMBL603141)
Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)N1CCCC(C1)C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C21H17ClF6N2O2/c22-16-3-5-17(6-4-16)29-18(31)12-2-1-7-30(11-12)19(32)13-8-14(20(23,24)25)10-15(9-13)21(26,27)28/h3-6,8-10,12H,1-2,7,11H2,(H,29,31)
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Article
PubMed
n/an/a 9.80E+3n/an/an/an/an/an/a



University of Michigan Medical School

Curated by ChEMBL


Assay Description
Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay


Bioorg Med Chem Lett 20: 665-72 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.056
BindingDB Entry DOI: 10.7270/Q29S1TTD
More data for this
Ligand-Target Pair
Rho-related GTP-binding protein RhoC


(Homo sapiens)
BDBM50481363
PNG
(CHEMBL589131)
Show SMILES FC(F)(F)c1cc(NC(=O)C2CCN(CC2)C(=O)c2ccc(Cl)cc2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C21H17ClF6N2O2/c22-16-3-1-13(2-4-16)19(32)30-7-5-12(6-8-30)18(31)29-17-10-14(20(23,24)25)9-15(11-17)21(26,27)28/h1-4,9-12H,5-8H2,(H,29,31)
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n/an/a 1.00E+4n/an/an/an/an/an/a



University of Michigan Medical School

Curated by ChEMBL


Assay Description
Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay


Bioorg Med Chem Lett 20: 665-72 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.056
BindingDB Entry DOI: 10.7270/Q29S1TTD
More data for this
Ligand-Target Pair
Rho-related GTP-binding protein RhoC


(Homo sapiens)
BDBM50481351
PNG
(CHEMBL602642)
Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)N1CCC(CC1)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C20H17ClF6N2O/c21-15-1-3-16(4-2-15)28-17-5-7-29(8-6-17)18(30)12-9-13(19(22,23)24)11-14(10-12)20(25,26)27/h1-4,9-11,17,28H,5-8H2
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n/an/a 1.08E+4n/an/an/an/an/an/a



University of Michigan Medical School

Curated by ChEMBL


Assay Description
Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay


Bioorg Med Chem Lett 20: 665-72 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.056
BindingDB Entry DOI: 10.7270/Q29S1TTD
More data for this
Ligand-Target Pair
Rho-related GTP-binding protein RhoC


(Homo sapiens)
BDBM50481349
PNG
(CHEMBL600670)
Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)NCCC(=O)N1CCc2cc(Cl)ccc12
Show InChI InChI=1S/C20H15ClF6N2O2/c21-15-1-2-16-11(9-15)4-6-29(16)17(30)3-5-28-18(31)12-7-13(19(22,23)24)10-14(8-12)20(25,26)27/h1-2,7-10H,3-6H2,(H,28,31)
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n/an/a 1.30E+4n/an/an/an/an/an/a



University of Michigan Medical School

Curated by ChEMBL


Assay Description
Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay


Bioorg Med Chem Lett 20: 665-72 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.056
BindingDB Entry DOI: 10.7270/Q29S1TTD
More data for this
Ligand-Target Pair
Rho-related GTP-binding protein RhoC


(Homo sapiens)
BDBM50481345
PNG
(CHEMBL590838)
Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)N1CCC(CC1)C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C21H17ClF6N2O2/c22-16-1-3-17(4-2-16)29-18(31)12-5-7-30(8-6-12)19(32)13-9-14(20(23,24)25)11-15(10-13)21(26,27)28/h1-4,9-12H,5-8H2,(H,29,31)
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n/an/a 1.60E+4n/an/an/an/an/an/a



University of Michigan Medical School

Curated by ChEMBL


Assay Description
Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay


Bioorg Med Chem Lett 20: 665-72 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.056
BindingDB Entry DOI: 10.7270/Q29S1TTD
More data for this
Ligand-Target Pair
Rho-related GTP-binding protein RhoC


(Homo sapiens)
BDBM50481346
PNG
(CHEMBL601501)
Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)N1CCC(C1)C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C20H15ClF6N2O2/c21-15-1-3-16(4-2-15)28-17(30)11-5-6-29(10-11)18(31)12-7-13(19(22,23)24)9-14(8-12)20(25,26)27/h1-4,7-9,11H,5-6,10H2,(H,28,30)
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n/an/a 1.63E+4n/an/an/an/an/an/a



University of Michigan Medical School

Curated by ChEMBL


Assay Description
Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay


Bioorg Med Chem Lett 20: 665-72 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.056
BindingDB Entry DOI: 10.7270/Q29S1TTD
More data for this
Ligand-Target Pair
Rho-related GTP-binding protein RhoC


(Homo sapiens)
BDBM50481339
PNG
(CHEMBL594913)
Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)NCCCC(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C19H15ClF6N2O2/c20-14-3-5-15(6-4-14)28-16(29)2-1-7-27-17(30)11-8-12(18(21,22)23)10-13(9-11)19(24,25)26/h3-6,8-10H,1-2,7H2,(H,27,30)(H,28,29)
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n/an/a 2.10E+4n/an/an/an/an/an/a



University of Michigan Medical School

Curated by ChEMBL


Assay Description
Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay


Bioorg Med Chem Lett 20: 665-72 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.056
BindingDB Entry DOI: 10.7270/Q29S1TTD
More data for this
Ligand-Target Pair
Rho-related GTP-binding protein RhoC


(Homo sapiens)
BDBM50481358
PNG
(CHEMBL584872)
Show SMILES FC(F)(F)c1cccc(c1)C(=O)NOCC(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C16H12ClF3N2O3/c17-12-4-6-13(7-5-12)21-14(23)9-25-22-15(24)10-2-1-3-11(8-10)16(18,19)20/h1-8H,9H2,(H,21,23)(H,22,24)
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n/an/a 2.70E+4n/an/an/an/an/an/a



University of Michigan Medical School

Curated by ChEMBL


Assay Description
Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay


Bioorg Med Chem Lett 20: 665-72 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.056
BindingDB Entry DOI: 10.7270/Q29S1TTD
More data for this
Ligand-Target Pair
Rho-related GTP-binding protein RhoC


(Homo sapiens)
BDBM50481366
PNG
(CHEMBL590358)
Show SMILES FC(F)(F)c1ccc(cc1)C(=O)NOCC(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C16H12ClF3N2O3/c17-12-5-7-13(8-6-12)21-14(23)9-25-22-15(24)10-1-3-11(4-2-10)16(18,19)20/h1-8H,9H2,(H,21,23)(H,22,24)
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n/an/a 2.90E+4n/an/an/an/an/an/a



University of Michigan Medical School

Curated by ChEMBL


Assay Description
Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay


Bioorg Med Chem Lett 20: 665-72 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.056
BindingDB Entry DOI: 10.7270/Q29S1TTD
More data for this
Ligand-Target Pair
Rho-related GTP-binding protein RhoC


(Homo sapiens)
BDBM50481338
PNG
(CHEMBL594912)
Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)NCC(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C17H11ClF6N2O2/c18-12-1-3-13(4-2-12)26-14(27)8-25-15(28)9-5-10(16(19,20)21)7-11(6-9)17(22,23)24/h1-7H,8H2,(H,25,28)(H,26,27)
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n/an/a 3.30E+4n/an/an/an/an/an/a



University of Michigan Medical School

Curated by ChEMBL


Assay Description
Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay


Bioorg Med Chem Lett 20: 665-72 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.056
BindingDB Entry DOI: 10.7270/Q29S1TTD
More data for this
Ligand-Target Pair
Rho-related GTP-binding protein RhoC


(Homo sapiens)
BDBM50481368
PNG
(CHEMBL591078)
Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)NOCC(=O)Nc1ccccc1
Show InChI InChI=1S/C17H12F6N2O3/c18-16(19,20)11-6-10(7-12(8-11)17(21,22)23)15(27)25-28-9-14(26)24-13-4-2-1-3-5-13/h1-8H,9H2,(H,24,26)(H,25,27)
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n/an/a 3.60E+4n/an/an/an/an/an/a



University of Michigan Medical School

Curated by ChEMBL


Assay Description
Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay


Bioorg Med Chem Lett 20: 665-72 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.056
BindingDB Entry DOI: 10.7270/Q29S1TTD
More data for this
Ligand-Target Pair
Rho-related GTP-binding protein RhoC


(Homo sapiens)
BDBM50481365
PNG
(CHEMBL608266)
Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)NCCC(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C18H13ClF6N2O2/c19-13-1-3-14(4-2-13)27-15(28)5-6-26-16(29)10-7-11(17(20,21)22)9-12(8-10)18(23,24)25/h1-4,7-9H,5-6H2,(H,26,29)(H,27,28)
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n/an/a 3.80E+4n/an/an/an/an/an/a



University of Michigan Medical School

Curated by ChEMBL


Assay Description
Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay


Bioorg Med Chem Lett 20: 665-72 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.056
BindingDB Entry DOI: 10.7270/Q29S1TTD
More data for this
Ligand-Target Pair
Rho-related GTP-binding protein RhoC


(Homo sapiens)
BDBM50481361
PNG
(CHEMBL591785)
Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)N1CCCC1C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C20H15ClF6N2O2/c21-14-3-5-15(6-4-14)28-17(30)16-2-1-7-29(16)18(31)11-8-12(19(22,23)24)10-13(9-11)20(25,26)27/h3-6,8-10,16H,1-2,7H2,(H,28,30)
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n/an/a 6.90E+4n/an/an/an/an/an/a



University of Michigan Medical School

Curated by ChEMBL


Assay Description
Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay


Bioorg Med Chem Lett 20: 665-72 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.056
BindingDB Entry DOI: 10.7270/Q29S1TTD
More data for this
Ligand-Target Pair
Rho-related GTP-binding protein RhoC


(Homo sapiens)
BDBM50481350
PNG
(CHEMBL595148)
Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)N1CCN(c2ccc(Cl)cc2)C(=O)CC1
Show InChI InChI=1S/C20H15ClF6N2O2/c21-15-1-3-16(4-2-15)29-8-7-28(6-5-17(29)30)18(31)12-9-13(19(22,23)24)11-14(10-12)20(25,26)27/h1-4,9-11H,5-8H2
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Michigan Medical School

Curated by ChEMBL


Assay Description
Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay


Bioorg Med Chem Lett 20: 665-72 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.056
BindingDB Entry DOI: 10.7270/Q29S1TTD
More data for this
Ligand-Target Pair
Rho-related GTP-binding protein RhoC


(Homo sapiens)
BDBM50481348
PNG
(CHEMBL600079)
Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1ccc(cc1)C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C22H13ClF6N2O2/c23-16-3-7-18(8-4-16)30-19(32)12-1-5-17(6-2-12)31-20(33)13-9-14(21(24,25)26)11-15(10-13)22(27,28)29/h1-11H,(H,30,32)(H,31,33)
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Michigan Medical School

Curated by ChEMBL


Assay Description
Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay


Bioorg Med Chem Lett 20: 665-72 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.056
BindingDB Entry DOI: 10.7270/Q29S1TTD
More data for this
Ligand-Target Pair
Rho-related GTP-binding protein RhoC


(Homo sapiens)
BDBM50481357
PNG
(CHEMBL590836)
Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)NCCCCC(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C20H17ClF6N2O2/c21-15-4-6-16(7-5-15)29-17(30)3-1-2-8-28-18(31)12-9-13(19(22,23)24)11-14(10-12)20(25,26)27/h4-7,9-11H,1-3,8H2,(H,28,31)(H,29,30)
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Michigan Medical School

Curated by ChEMBL


Assay Description
Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay


Bioorg Med Chem Lett 20: 665-72 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.056
BindingDB Entry DOI: 10.7270/Q29S1TTD
More data for this
Ligand-Target Pair
Rho-related GTP-binding protein RhoC


(Homo sapiens)
BDBM50481341
PNG
(CHEMBL591079)
Show SMILES Clc1ccc(NC(=O)CONC(=O)c2ccccc2)cc1
Show InChI InChI=1S/C15H13ClN2O3/c16-12-6-8-13(9-7-12)17-14(19)10-21-18-15(20)11-4-2-1-3-5-11/h1-9H,10H2,(H,17,19)(H,18,20)
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Michigan Medical School

Curated by ChEMBL


Assay Description
Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay


Bioorg Med Chem Lett 20: 665-72 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.056
BindingDB Entry DOI: 10.7270/Q29S1TTD
More data for this
Ligand-Target Pair
Rho-related GTP-binding protein RhoC


(Homo sapiens)
BDBM50481367
PNG
(CHEMBL592020)
Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)N[C@@H]1CCC[C@@H]1C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C21H17ClF6N2O2/c22-14-4-6-15(7-5-14)29-19(32)16-2-1-3-17(16)30-18(31)11-8-12(20(23,24)25)10-13(9-11)21(26,27)28/h4-10,16-17H,1-3H2,(H,29,32)(H,30,31)/t16-,17+/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Michigan Medical School

Curated by ChEMBL


Assay Description
Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay


Bioorg Med Chem Lett 20: 665-72 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.056
BindingDB Entry DOI: 10.7270/Q29S1TTD
More data for this
Ligand-Target Pair
Rho-related GTP-binding protein RhoC


(Homo sapiens)
BDBM50481370
PNG
(CHEMBL591082)
Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)Nc1ccccc1C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C22H13ClF6N2O2/c23-15-5-7-16(8-6-15)30-20(33)17-3-1-2-4-18(17)31-19(32)12-9-13(21(24,25)26)11-14(10-12)22(27,28)29/h1-11H,(H,30,33)(H,31,32)
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Michigan Medical School

Curated by ChEMBL


Assay Description
Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay


Bioorg Med Chem Lett 20: 665-72 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.056
BindingDB Entry DOI: 10.7270/Q29S1TTD
More data for this
Ligand-Target Pair
Rho-related GTP-binding protein RhoC


(Homo sapiens)
BDBM50481353
PNG
(CHEMBL602447)
Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)-n1cc(CCC(=O)Nc2ccc(Cl)cc2)nn1
Show InChI InChI=1S/C19H13ClF6N4O/c20-13-1-3-14(4-2-13)27-17(31)6-5-15-10-30(29-28-15)16-8-11(18(21,22)23)7-12(9-16)19(24,25)26/h1-4,7-10H,5-6H2,(H,27,31)
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Michigan Medical School

Curated by ChEMBL


Assay Description
Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay


Bioorg Med Chem Lett 20: 665-72 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.056
BindingDB Entry DOI: 10.7270/Q29S1TTD
More data for this
Ligand-Target Pair
Rho-related GTP-binding protein RhoC


(Homo sapiens)
BDBM50481354
PNG
(CHEMBL589373)
Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)NCCc1cn(nn1)-c1ccccc1
Show InChI InChI=1S/C19H14F6N4O/c20-18(21,22)13-8-12(9-14(10-13)19(23,24)25)17(30)26-7-6-15-11-29(28-27-15)16-4-2-1-3-5-16/h1-5,8-11H,6-7H2,(H,26,30)
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Michigan Medical School

Curated by ChEMBL


Assay Description
Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay


Bioorg Med Chem Lett 20: 665-72 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.056
BindingDB Entry DOI: 10.7270/Q29S1TTD
More data for this
Ligand-Target Pair
Rho-related GTP-binding protein RhoC


(Homo sapiens)
BDBM50481355
PNG
(CHEMBL591313)
Show SMILES CN(C(=O)CCNC(=O)c1cc(cc(c1)C(F)(F)F)C(F)(F)F)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H15ClF6N2O2/c1-28(15-4-2-14(20)3-5-15)16(29)6-7-27-17(30)11-8-12(18(21,22)23)10-13(9-11)19(24,25)26/h2-5,8-10H,6-7H2,1H3,(H,27,30)
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Michigan Medical School

Curated by ChEMBL


Assay Description
Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay


Bioorg Med Chem Lett 20: 665-72 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.056
BindingDB Entry DOI: 10.7270/Q29S1TTD
More data for this
Ligand-Target Pair
Rho-related GTP-binding protein RhoC


(Homo sapiens)
BDBM50481342
PNG
(CHEMBL590595)
Show SMILES FC(F)(F)c1cc(cc(c1)C(F)(F)F)C(=O)NCCC(=O)NCc1ccc(Cl)cc1
Show InChI InChI=1S/C19H15ClF6N2O2/c20-15-3-1-11(2-4-15)10-28-16(29)5-6-27-17(30)12-7-13(18(21,22)23)9-14(8-12)19(24,25)26/h1-4,7-9H,5-6,10H2,(H,27,30)(H,28,29)
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n/an/a>1.00E+5n/an/an/an/an/an/a



University of Michigan Medical School

Curated by ChEMBL


Assay Description
Inhibition of RhoA/C-mediated transcriptional response in human PC3 cells by serum response factor-luciferase reporter gene assay


Bioorg Med Chem Lett 20: 665-72 (2010)


Article DOI: 10.1016/j.bmcl.2009.11.056
BindingDB Entry DOI: 10.7270/Q29S1TTD
More data for this
Ligand-Target Pair