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Compile Data Set for Download or QSAR

Found 603 hits of ic50 for UniProtKB: P00749   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50194745
PNG
(CHEMBL385900 | diphenyl 1-[(N-2-thiophenesulfonyl-...)
Show SMILES C[C@H](NC(=O)[C@@H](CO)NS(=O)(=O)c1cccs1)C(=O)NC(Cc1ccc(cc1)N=C(N)N)P(=O)(Oc1ccccc1)Oc1ccccc1
Show InChI InChI=1S/C31H35N6O8PS2/c1-21(34-30(40)26(20-38)37-48(42,43)28-13-8-18-47-28)29(39)36-27(19-22-14-16-23(17-15-22)35-31(32)33)46(41,44-24-9-4-2-5-10-24)45-25-11-6-3-7-12-25/h2-18,21,26-27,37-38H,19-20H2,1H3,(H,34,40)(H,36,39)(H4,32,33,35)/t21-,26+,27?/m0/s1
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n/an/a 1.5n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA


J Med Chem 49: 5785-93 (2006)


Article DOI: 10.1021/jm060622g
BindingDB Entry DOI: 10.7270/Q2SF2VT3
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50093542
PNG
(CHEMBL3585742)
Show SMILES Cn1c(CN2C(=O)CN(C2=O)c2ccc(F)cc2)nc2ccc(cc12)C(=O)N[C@@H](CCCCN)C#N
Show InChI InChI=1S/C25H26FN7O3/c1-31-21-12-16(24(35)29-18(13-28)4-2-3-11-27)5-10-20(21)30-22(31)14-33-23(34)15-32(25(33)36)19-8-6-17(26)7-9-19/h5-10,12,18H,2-4,11,14-15,27H2,1H3,(H,29,35)/t18-/m0/s1
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n/an/a>2n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Inhibition of plasmin (unknown origin) using Boc-Val-Leu-Lys-MCA as substrate by fluorescence analysis


Bioorg Med Chem 23: 3696-704 (2015)


Article DOI: 10.1016/j.bmc.2015.04.013
BindingDB Entry DOI: 10.7270/Q2X92D2Q
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50093540
PNG
(CHEMBL3585746)
Show SMILES Cn1c(CN2C(=O)CN(C2=O)c2ccc(Oc3ccncc3)cc2)nc2ccc(cc12)C(=O)N[C@@H](CCCCN)C#N
Show InChI InChI=1S/C30H30N8O4/c1-36-26-16-20(29(40)34-21(17-32)4-2-3-13-31)5-10-25(26)35-27(36)18-38-28(39)19-37(30(38)41)22-6-8-23(9-7-22)42-24-11-14-33-15-12-24/h5-12,14-16,21H,2-4,13,18-19,31H2,1H3,(H,34,40)/t21-/m0/s1
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n/an/a>2n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Inhibition of plasmin (unknown origin) using Boc-Val-Leu-Lys-MCA as substrate by fluorescence analysis


Bioorg Med Chem 23: 3696-704 (2015)


Article DOI: 10.1016/j.bmc.2015.04.013
BindingDB Entry DOI: 10.7270/Q2X92D2Q
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50009171
PNG
(CHEMBL3238362)
Show SMILES Cn1c(CN2C(=O)CN(C2=O)c2ccc(F)cc2)cc2cnc(nc12)C(=O)N[C@@H](CCCCN)C#N
Show InChI InChI=1S/C24H25FN8O3/c1-31-19(13-33-20(34)14-32(24(33)36)18-7-5-16(25)6-8-18)10-15-12-28-21(30-22(15)31)23(35)29-17(11-27)4-2-3-9-26/h5-8,10,12,17H,2-4,9,13-14,26H2,1H3,(H,29,35)/t17-/m0/s1
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n/an/a>2n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Inhibition of plasmin (unknown origin) using Boc-Val-Leu-Lys-MCA as substrate by fluorescence analysis


Bioorg Med Chem 23: 3696-704 (2015)


Article DOI: 10.1016/j.bmc.2015.04.013
BindingDB Entry DOI: 10.7270/Q2X92D2Q
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50093541
PNG
(CHEMBL3585745)
Show SMILES Cn1c(CN2C(=O)CN(C2=O)c2ccc(Oc3ccncc3)cc2)cc2cnc(nc12)C(=O)N[C@@H](CCCCN)C#N
Show InChI InChI=1S/C29H29N9O4/c1-36-22(14-19-16-33-26(35-27(19)36)28(40)34-20(15-31)4-2-3-11-30)17-38-25(39)18-37(29(38)41)21-5-7-23(8-6-21)42-24-9-12-32-13-10-24/h5-10,12-14,16,20H,2-4,11,17-18,30H2,1H3,(H,34,40)/t20-/m0/s1
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n/an/a>2n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Inhibition of plasmin (unknown origin) using Boc-Val-Leu-Lys-MCA as substrate by fluorescence analysis


Bioorg Med Chem 23: 3696-704 (2015)


Article DOI: 10.1016/j.bmc.2015.04.013
BindingDB Entry DOI: 10.7270/Q2X92D2Q
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50009200
PNG
(CHEMBL3238374)
Show SMILES Cn1c(CN2C(=O)CN(C2=O)c2ccc(Oc3ccccc3)cc2)cc2cnc(nc12)C(=O)N[C@@H](CCCCN)C#N
Show InChI InChI=1S/C30H30N8O4/c1-36-23(15-20-17-33-27(35-28(20)36)29(40)34-21(16-32)7-5-6-14-31)18-38-26(39)19-37(30(38)41)22-10-12-25(13-11-22)42-24-8-3-2-4-9-24/h2-4,8-13,15,17,21H,5-7,14,18-19,31H2,1H3,(H,34,40)/t21-/m0/s1
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n/an/a>2n/an/an/an/an/an/a



Hiroshima International University

Curated by ChEMBL


Assay Description
Inhibition of plasmin (unknown origin) using Boc-Val-Leu-Lys-MCA as substrate by fluorescence analysis


Bioorg Med Chem 23: 3696-704 (2015)


Article DOI: 10.1016/j.bmc.2015.04.013
BindingDB Entry DOI: 10.7270/Q2X92D2Q
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50194741
PNG
(CHEMBL385158 | diphenyl 1-[(N-benzenesulfonyl-D-se...)
Show SMILES C[C@H](NC(=O)[C@@H](CO)NS(=O)(=O)c1ccccc1)C(=O)NC(Cc1ccc(cc1)N=C(N)N)P(=O)(Oc1ccccc1)Oc1ccccc1
Show InChI InChI=1S/C33H37N6O8PS/c1-23(36-32(42)29(22-40)39-49(44,45)28-15-9-4-10-16-28)31(41)38-30(21-24-17-19-25(20-18-24)37-33(34)35)48(43,46-26-11-5-2-6-12-26)47-27-13-7-3-8-14-27/h2-20,23,29-30,39-40H,21-22H2,1H3,(H,36,42)(H,38,41)(H4,34,35,37)/t23-,29+,30?/m0/s1
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n/an/a 2.60n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA


J Med Chem 49: 5785-93 (2006)


Article DOI: 10.1021/jm060622g
BindingDB Entry DOI: 10.7270/Q2SF2VT3
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50088982
PNG
(CHEMBL160253 | CHEMBL367004 | N-[1-(1-Carbamimidoy...)
Show SMILES C[C@H](NC(=O)[C@@H](CO)NS(=O)(=O)CCc1ccccc1)C(=O)N[C@H]1CCCN(C1O)C(N)=N
Show InChI InChI=1S/C20H32N6O6S/c1-13(17(28)24-15-8-5-10-26(19(15)30)20(21)22)23-18(29)16(12-27)25-33(31,32)11-9-14-6-3-2-4-7-14/h2-4,6-7,13,15-16,19,25,27,30H,5,8-12H2,1H3,(H3,21,22)(H,23,29)(H,24,28)/t13-,15-,16+,19?/m0/s1
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n/an/a 3.10n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
The compound was tested in vitro for its inhibitory activity against human urokinase enzyme, activity expressed as IC50


Bioorg Med Chem Lett 10: 983-7 (2000)


Article DOI: 10.1016/s0960-894x(00)00149-9
BindingDB Entry DOI: 10.7270/Q2765DKB
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50228418
PNG
(CHEMBL393591 | methyl 1-(diphenoxyphosphoryl)-2-(4...)
Show SMILES COC(=O)NC(Cc1ccc(cc1)N=C(N)N)P(=O)(Oc1ccccc1)Oc1ccccc1
Show InChI InChI=1S/C23H25N4O5P/c1-30-23(28)27-21(16-17-12-14-18(15-13-17)26-22(24)25)33(29,31-19-8-4-2-5-9-19)32-20-10-6-3-7-11-20/h2-15,21H,16H2,1H3,(H,27,28)(H4,24,25,26)
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n/an/a 3.10n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA


J Med Chem 50: 6638-46 (2007)


Article DOI: 10.1021/jm700962j
BindingDB Entry DOI: 10.7270/Q2MW2J0J
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50228412
PNG
(CHEMBL393979 | methyl 1-(bis(4-acetamidophenoxy)ph...)
Show SMILES COC(=O)NC(Cc1ccc(cc1)N=C(N)N)P(=O)(Oc1ccc(NC(C)=O)cc1)Oc1ccc(NC(C)=O)cc1
Show InChI InChI=1S/C27H31N6O7P/c1-17(34)30-20-8-12-23(13-9-20)39-41(37,40-24-14-10-21(11-15-24)31-18(2)35)25(33-27(36)38-3)16-19-4-6-22(7-5-19)32-26(28)29/h4-15,25H,16H2,1-3H3,(H,30,34)(H,31,35)(H,33,36)(H4,28,29,32)
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n/an/a 3.40n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA


J Med Chem 50: 6638-46 (2007)


Article DOI: 10.1021/jm700962j
BindingDB Entry DOI: 10.7270/Q2MW2J0J
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50228425
PNG
(CHEMBL239118 | di-(4-acetamidophenyl) 1-(methylsul...)
Show SMILES CC(=O)Nc1ccc(OP(=O)(Oc2ccc(NC(C)=O)cc2)C(Cc2ccc(cc2)N=C(N)N)NS(C)(=O)=O)cc1
Show InChI InChI=1S/C26H31N6O7PS/c1-17(33)29-20-8-12-23(13-9-20)38-40(35,39-24-14-10-21(11-15-24)30-18(2)34)25(32-41(3,36)37)16-19-4-6-22(7-5-19)31-26(27)28/h4-15,25,32H,16H2,1-3H3,(H,29,33)(H,30,34)(H4,27,28,31)
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n/an/a 3.5n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA


J Med Chem 50: 6638-46 (2007)


Article DOI: 10.1021/jm700962j
BindingDB Entry DOI: 10.7270/Q2MW2J0J
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50194743
PNG
(CHEMBL214814 | diphenyl 1-[(N-alpha-toluenesulfony...)
Show SMILES C[C@H](NC(=O)[C@@H](CO)NS(=O)(=O)Cc1ccccc1)C(=O)NC(Cc1ccc(cc1)N=C(N)N)P(=O)(Oc1ccccc1)Oc1ccccc1
Show InChI InChI=1S/C34H39N6O8PS/c1-24(37-33(43)30(22-41)40-50(45,46)23-26-11-5-2-6-12-26)32(42)39-31(21-25-17-19-27(20-18-25)38-34(35)36)49(44,47-28-13-7-3-8-14-28)48-29-15-9-4-10-16-29/h2-20,24,30-31,40-41H,21-23H2,1H3,(H,37,43)(H,39,42)(H4,35,36,38)/t24-,30+,31?/m0/s1
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n/an/a 3.5n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA


J Med Chem 49: 5785-93 (2006)


Article DOI: 10.1021/jm060622g
BindingDB Entry DOI: 10.7270/Q2SF2VT3
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50194743
PNG
(CHEMBL214814 | diphenyl 1-[(N-alpha-toluenesulfony...)
Show SMILES C[C@H](NC(=O)[C@@H](CO)NS(=O)(=O)Cc1ccccc1)C(=O)NC(Cc1ccc(cc1)N=C(N)N)P(=O)(Oc1ccccc1)Oc1ccccc1
Show InChI InChI=1S/C34H39N6O8PS/c1-24(37-33(43)30(22-41)40-50(45,46)23-26-11-5-2-6-12-26)32(42)39-31(21-25-17-19-27(20-18-25)38-34(35)36)49(44,47-28-13-7-3-8-14-28)48-29-15-9-4-10-16-29/h2-20,24,30-31,40-41H,21-23H2,1H3,(H,37,43)(H,39,42)(H4,35,36,38)/t24-,30+,31?/m0/s1
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n/an/a 4n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA


J Med Chem 50: 6638-46 (2007)


Article DOI: 10.1021/jm700962j
BindingDB Entry DOI: 10.7270/Q2MW2J0J
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50228420
PNG
(CHEMBL391968 | di-(4-acetamidophenyl) 1-(benzyloxy...)
Show SMILES CC(=O)Nc1ccc(OP(=O)(Oc2ccc(NC(C)=O)cc2)C(Cc2ccc(cc2)N=C(N)N)NC(=O)OCc2ccccc2)cc1
Show InChI InChI=1S/C33H35N6O7P/c1-22(40)36-26-12-16-29(17-13-26)45-47(43,46-30-18-14-27(15-19-30)37-23(2)41)31(20-24-8-10-28(11-9-24)38-32(34)35)39-33(42)44-21-25-6-4-3-5-7-25/h3-19,31H,20-21H2,1-2H3,(H,36,40)(H,37,41)(H,39,42)(H4,34,35,38)
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n/an/a 4.20n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA


J Med Chem 50: 6638-46 (2007)


Article DOI: 10.1021/jm700962j
BindingDB Entry DOI: 10.7270/Q2MW2J0J
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50145689
PNG
(CHEMBL80844 | [1-[(S)-2-((R)-2-Benzyloxycarbonylam...)
Show SMILES C[C@H](NC(=O)[C@@H](CO)NC(=O)OCc1ccccc1)C(=O)NC(Cc1ccc(cc1)N=C(N)N)P(=O)(Oc1ccccc1)Oc1ccccc1
Show InChI InChI=1S/C35H39N6O8P/c1-24(38-33(44)30(22-42)40-35(45)47-23-26-11-5-2-6-12-26)32(43)41-31(21-25-17-19-27(20-18-25)39-34(36)37)50(46,48-28-13-7-3-8-14-28)49-29-15-9-4-10-16-29/h2-20,24,30-31,42H,21-23H2,1H3,(H,38,44)(H,40,45)(H,41,43)(H4,36,37,39)/t24-,30+,31?/m0/s1
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n/an/a 4.30n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA


J Med Chem 49: 5785-93 (2006)


Article DOI: 10.1021/jm060622g
BindingDB Entry DOI: 10.7270/Q2SF2VT3
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50194737
PNG
(CHEMBL384263 | diphenyl 1-[(N-o-methylbenzoyl-D-se...)
Show SMILES C[C@H](NC(=O)[C@@H](CO)NC(=O)c1cccc(C)c1)C(=O)NC(Cc1ccc(cc1)N=C(N)N)P(=O)(Oc1ccccc1)Oc1ccccc1
Show InChI InChI=1S/C35H39N6O7P/c1-23-10-9-11-26(20-23)33(44)40-30(22-42)34(45)38-24(2)32(43)41-31(21-25-16-18-27(19-17-25)39-35(36)37)49(46,47-28-12-5-3-6-13-28)48-29-14-7-4-8-15-29/h3-20,24,30-31,42H,21-22H2,1-2H3,(H,38,45)(H,40,44)(H,41,43)(H4,36,37,39)/t24-,30+,31?/m0/s1
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n/an/a 4.40n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA


J Med Chem 49: 5785-93 (2006)


Article DOI: 10.1021/jm060622g
BindingDB Entry DOI: 10.7270/Q2SF2VT3
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50194742
PNG
(CHEMBL263977 | diphenyl 1-[(N-benzyl-D-seryl)-L-al...)
Show SMILES C[C@H](NC(=O)[C@@H](CO)NC(=O)c1ccccc1)C(=O)NC(Cc1ccc(cc1)N=C(N)N)P(=O)(Oc1ccccc1)Oc1ccccc1
Show InChI InChI=1S/C34H37N6O7P/c1-23(37-33(44)29(22-41)39-32(43)25-11-5-2-6-12-25)31(42)40-30(21-24-17-19-26(20-18-24)38-34(35)36)48(45,46-27-13-7-3-8-14-27)47-28-15-9-4-10-16-28/h2-20,23,29-30,41H,21-22H2,1H3,(H,37,44)(H,39,43)(H,40,42)(H4,35,36,38)/t23-,29+,30?/m0/s1
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n/an/a 5n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA


J Med Chem 49: 5785-93 (2006)


Article DOI: 10.1021/jm060622g
BindingDB Entry DOI: 10.7270/Q2SF2VT3
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50194746
PNG
(CHEMBL405546 | diphenyl 1-[(N-o-methylbenzoyl-D-se...)
Show SMILES C[C@H](NC(=O)[C@@H](CO)NC(=O)c1ccccc1C)C(=O)NC(Cc1ccc(cc1)N=C(N)N)P(=O)(Oc1ccccc1)Oc1ccccc1
Show InChI InChI=1S/C35H39N6O7P/c1-23-11-9-10-16-29(23)33(44)40-30(22-42)34(45)38-24(2)32(43)41-31(21-25-17-19-26(20-18-25)39-35(36)37)49(46,47-27-12-5-3-6-13-27)48-28-14-7-4-8-15-28/h3-20,24,30-31,42H,21-22H2,1-2H3,(H,38,45)(H,40,44)(H,41,43)(H4,36,37,39)/t24-,30+,31?/m0/s1
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n/an/a 5n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA


J Med Chem 49: 5785-93 (2006)


Article DOI: 10.1021/jm060622g
BindingDB Entry DOI: 10.7270/Q2SF2VT3
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50088978
PNG
(CHEMBL176515 | N-[1-(1-Carbamimidoyl-2-hydroxy-pip...)
Show SMILES C[C@H](NC(=O)[C@@H](CO)NS(=O)(=O)Cc1ccccc1)C(=O)N[C@H]1CCCN(C1O)C(N)=N
Show InChI InChI=1S/C19H30N6O6S/c1-12(16(27)23-14-8-5-9-25(18(14)29)19(20)21)22-17(28)15(10-26)24-32(30,31)11-13-6-3-2-4-7-13/h2-4,6-7,12,14-15,18,24,26,29H,5,8-11H2,1H3,(H3,20,21)(H,22,28)(H,23,27)/t12-,14-,15+,18?/m0/s1
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n/an/a 5.10n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
The compound was tested in vitro for its inhibitory activity against human urokinase enzyme, activity expressed as IC50


Bioorg Med Chem Lett 10: 983-7 (2000)


Article DOI: 10.1016/s0960-894x(00)00149-9
BindingDB Entry DOI: 10.7270/Q2765DKB
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50194744
PNG
(CHEMBL385897 | diphenyl 1-[(N-naphthalenesulfonyl-...)
Show SMILES C[C@H](NC(=O)[C@@H](CO)NS(=O)(=O)c1cccc2ccccc12)C(=O)NC(Cc1ccc(cc1)N=C(N)N)P(=O)(Oc1ccccc1)Oc1ccccc1
Show InChI InChI=1S/C37H39N6O8PS/c1-25(40-36(46)32(24-44)43-53(48,49)33-18-10-12-27-11-8-9-17-31(27)33)35(45)42-34(23-26-19-21-28(22-20-26)41-37(38)39)52(47,50-29-13-4-2-5-14-29)51-30-15-6-3-7-16-30/h2-22,25,32,34,43-44H,23-24H2,1H3,(H,40,46)(H,42,45)(H4,38,39,41)/t25-,32+,34?/m0/s1
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n/an/a 5.80n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA


J Med Chem 49: 5785-93 (2006)


Article DOI: 10.1021/jm060622g
BindingDB Entry DOI: 10.7270/Q2SF2VT3
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50194734
PNG
(CHEMBL386275 | diphenyl 1-[(N-p-methoxybenzenesulf...)
Show SMILES COc1ccc(cc1)S(=O)(=O)N[C@H](CO)C(=O)N[C@@H](C)C(=O)NC(Cc1ccc(cc1)N=C(N)N)P(=O)(Oc1ccccc1)Oc1ccccc1
Show InChI InChI=1S/C34H39N6O9PS/c1-23(37-33(43)30(22-41)40-51(45,46)29-19-17-26(47-2)18-20-29)32(42)39-31(21-24-13-15-25(16-14-24)38-34(35)36)50(44,48-27-9-5-3-6-10-27)49-28-11-7-4-8-12-28/h3-20,23,30-31,40-41H,21-22H2,1-2H3,(H,37,43)(H,39,42)(H4,35,36,38)/t23-,30+,31?/m0/s1
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n/an/a 5.80n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA


J Med Chem 49: 5785-93 (2006)


Article DOI: 10.1021/jm060622g
BindingDB Entry DOI: 10.7270/Q2SF2VT3
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50194736
PNG
(CHEMBL189823 | diphenyl 1-[(N-o,o-dimethylbenzoyl-...)
Show SMILES C[C@H](NC(=O)[C@@H](CO)NC(=O)c1c(C)cccc1C)C(=O)NC(Cc1ccc(cc1)N=C(N)N)P(=O)(Oc1ccccc1)Oc1ccccc1
Show InChI InChI=1S/C36H41N6O7P/c1-23-11-10-12-24(2)32(23)35(46)41-30(22-43)34(45)39-25(3)33(44)42-31(21-26-17-19-27(20-18-26)40-36(37)38)50(47,48-28-13-6-4-7-14-28)49-29-15-8-5-9-16-29/h4-20,25,30-31,43H,21-22H2,1-3H3,(H,39,45)(H,41,46)(H,42,44)(H4,37,38,40)/t25-,30+,31?/m0/s1
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n/an/a 6n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA


J Med Chem 49: 5785-93 (2006)


Article DOI: 10.1021/jm060622g
BindingDB Entry DOI: 10.7270/Q2SF2VT3
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50194735
PNG
(CHEMBL215961 | diphenyl 1-[(N-p-cyanobenzenesulfon...)
Show SMILES C[C@H](NC(=O)[C@@H](CO)NS(=O)(=O)c1ccc(cc1)C#N)C(=O)NC(Cc1ccc(cc1)N=C(N)N)P(=O)(Oc1ccccc1)Oc1ccccc1
Show InChI InChI=1S/C34H36N7O8PS/c1-23(38-33(44)30(22-42)41-51(46,47)29-18-14-25(21-35)15-19-29)32(43)40-31(20-24-12-16-26(17-13-24)39-34(36)37)50(45,48-27-8-4-2-5-9-27)49-28-10-6-3-7-11-28/h2-19,23,30-31,41-42H,20,22H2,1H3,(H,38,44)(H,40,43)(H4,36,37,39)/t23-,30+,31?/m0/s1
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n/an/a 6.20n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA


J Med Chem 49: 5785-93 (2006)


Article DOI: 10.1021/jm060622g
BindingDB Entry DOI: 10.7270/Q2SF2VT3
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50194738
PNG
(CHEMBL386249 | diphenyl 1-[(N-p-bromobenzenesulfon...)
Show SMILES C[C@H](NC(=O)[C@@H](CO)NS(=O)(=O)c1ccc(Br)cc1)C(=O)NC(Cc1ccc(cc1)N=C(N)N)P(=O)(Oc1ccccc1)Oc1ccccc1
Show InChI InChI=1S/C33H36BrN6O8PS/c1-22(37-32(43)29(21-41)40-50(45,46)28-18-14-24(34)15-19-28)31(42)39-30(20-23-12-16-25(17-13-23)38-33(35)36)49(44,47-26-8-4-2-5-9-26)48-27-10-6-3-7-11-27/h2-19,22,29-30,40-41H,20-21H2,1H3,(H,37,43)(H,39,42)(H4,35,36,38)/t22-,29+,30?/m0/s1
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n/an/a 6.60n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA


J Med Chem 49: 5785-93 (2006)


Article DOI: 10.1021/jm060622g
BindingDB Entry DOI: 10.7270/Q2SF2VT3
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50228421
PNG
(CHEMBL238493 | diphenyl 1-(methylsulfonylamino)-2-...)
Show SMILES CS(=O)(=O)NC(Cc1ccc(cc1)N=C(N)N)P(=O)(Oc1ccccc1)Oc1ccccc1
Show InChI InChI=1S/C22H25N4O5PS/c1-33(28,29)26-21(16-17-12-14-18(15-13-17)25-22(23)24)32(27,30-19-8-4-2-5-9-19)31-20-10-6-3-7-11-20/h2-15,21,26H,16H2,1H3,(H4,23,24,25)
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n/an/a 6.60n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA


J Med Chem 50: 6638-46 (2007)


Article DOI: 10.1021/jm700962j
BindingDB Entry DOI: 10.7270/Q2MW2J0J
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM92479
PNG
(Tannic Acid, A)
Show SMILES Oc1cc(cc(O)c1O)C(=O)Oc1cc(cc(O)c1O)C(=O)OCC1OC(OC(=O)c2cc(O)c(O)c(OC(=O)c3cc(O)c(O)c(O)c3)c2)C(OC(=O)c2cc(O)c(O)c(OC(=O)c3cc(O)c(O)c(O)c3)c2)C(OC(=O)c2cc(O)c(O)c(OC(=O)c3cc(O)c(O)c(O)c3)c2)C1OC(=O)c1cc(O)c(O)c(OC(=O)c2cc(O)c(O)c(O)c2)c1
Show InChI InChI=1S/C76H52O46/c77-32-1-22(2-33(78)53(32)92)67(103)113-47-16-27(11-42(87)58(47)97)66(102)112-21-52-63(119-72(108)28-12-43(88)59(98)48(17-28)114-68(104)23-3-34(79)54(93)35(80)4-23)64(120-73(109)29-13-44(89)60(99)49(18-29)115-69(105)24-5-36(81)55(94)37(82)6-24)65(121-74(110)30-14-45(90)61(100)50(19-30)116-70(106)25-7-38(83)56(95)39(84)8-25)76(118-52)122-75(111)31-15-46(91)62(101)51(20-31)117-71(107)26-9-40(85)57(96)41(86)10-26/h1-20,52,63-65,76-101H,21H2
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n/an/a 6.60n/an/an/an/a7.823



University of Michigan



Assay Description
Enzyme activity assay using human and murine PAI-1.


J Biol Chem 285: 7892-902 (2010)


Article DOI: 10.1074/jbc.M109.067967
BindingDB Entry DOI: 10.7270/Q2ZC81FC
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50194732
PNG
(CHEMBL214539 | di-(4-acetamidophenyl) 1-[(N-benzyl...)
Show SMILES C[C@H](NC(=O)[C@@H](CO)NC(=O)OCc1ccccc1)C(=O)NC(Cc1ccc(cc1)N=C(N)N)P(=O)(Oc1ccc(NC(C)=O)cc1)Oc1ccc(NC(C)=O)cc1
Show InChI InChI=1S/C39H45N8O10P/c1-24(42-37(52)34(22-48)46-39(53)55-23-28-7-5-4-6-8-28)36(51)47-35(21-27-9-11-31(12-10-27)45-38(40)41)58(54,56-32-17-13-29(14-18-32)43-25(2)49)57-33-19-15-30(16-20-33)44-26(3)50/h4-20,24,34-35,48H,21-23H2,1-3H3,(H,42,52)(H,43,49)(H,44,50)(H,46,53)(H,47,51)(H4,40,41,45)/t24-,34+,35?/m0/s1
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n/an/a 6.70n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into biotin-linked K-ras decapeptide (CVIM) by bovine farnesyltransferase


J Med Chem 49: 5785-93 (2006)


Article DOI: 10.1021/jm060622g
BindingDB Entry DOI: 10.7270/Q2SF2VT3
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50194739
PNG
(CHEMBL213216 | diphenyl 1-[(N-2-thienyl-D-seryl)-L...)
Show SMILES C[C@H](NC(=O)[C@@H](CO)NC(=O)c1cccs1)C(=O)NC(Cc1ccc(cc1)N=C(N)N)P(=O)(Oc1ccccc1)Oc1ccccc1
Show InChI InChI=1S/C32H35N6O7PS/c1-21(35-30(41)26(20-39)37-31(42)27-13-8-18-47-27)29(40)38-28(19-22-14-16-23(17-15-22)36-32(33)34)46(43,44-24-9-4-2-5-10-24)45-25-11-6-3-7-12-25/h2-18,21,26,28,39H,19-20H2,1H3,(H,35,41)(H,37,42)(H,38,40)(H4,33,34,36)/t21-,26+,28?/m0/s1
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n/an/a 6.90n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA


J Med Chem 49: 5785-93 (2006)


Article DOI: 10.1021/jm060622g
BindingDB Entry DOI: 10.7270/Q2SF2VT3
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50194740
PNG
(CHEMBL404226 | diphenyl 1-[(N-p-methylbenzoyl-D-se...)
Show SMILES C[C@H](NC(=O)[C@@H](CO)NC(=O)c1ccc(C)cc1)C(=O)NC(Cc1ccc(cc1)N=C(N)N)P(=O)(Oc1ccccc1)Oc1ccccc1
Show InChI InChI=1S/C35H39N6O7P/c1-23-13-17-26(18-14-23)33(44)40-30(22-42)34(45)38-24(2)32(43)41-31(21-25-15-19-27(20-16-25)39-35(36)37)49(46,47-28-9-5-3-6-10-28)48-29-11-7-4-8-12-29/h3-20,24,30-31,42H,21-22H2,1-2H3,(H,38,45)(H,40,44)(H,41,43)(H4,36,37,39)/t24-,30+,31?/m0/s1
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n/an/a 7n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA


J Med Chem 49: 5785-93 (2006)


Article DOI: 10.1021/jm060622g
BindingDB Entry DOI: 10.7270/Q2SF2VT3
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50228410
PNG
(CHEMBL239535 | diphenyl 1-(benzyloxycarbonylamino)...)
Show SMILES NC(N)=Nc1ccc(CC(NC(=O)OCc2ccccc2)P(=O)(Oc2ccccc2)Oc2ccccc2)cc1
Show InChI InChI=1S/C29H29N4O5P/c30-28(31)32-24-18-16-22(17-19-24)20-27(33-29(34)36-21-23-10-4-1-5-11-23)39(35,37-25-12-6-2-7-13-25)38-26-14-8-3-9-15-26/h1-19,27H,20-21H2,(H,33,34)(H4,30,31,32)
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n/an/a 7n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA


J Med Chem 50: 6638-46 (2007)


Article DOI: 10.1021/jm700962j
BindingDB Entry DOI: 10.7270/Q2MW2J0J
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50228414
PNG
(CHEMBL239747 | diphenyl 1-acetamido-2-(4-guanidino...)
Show SMILES CC(=O)NC(Cc1ccc(cc1)N=C(N)N)P(=O)(Oc1ccccc1)Oc1ccccc1
Show InChI InChI=1S/C23H25N4O4P/c1-17(28)26-22(16-18-12-14-19(15-13-18)27-23(24)25)32(29,30-20-8-4-2-5-9-20)31-21-10-6-3-7-11-21/h2-15,22H,16H2,1H3,(H,26,28)(H4,24,25,27)
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n/an/a 7.20n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA


J Med Chem 50: 6638-46 (2007)


Article DOI: 10.1021/jm700962j
BindingDB Entry DOI: 10.7270/Q2MW2J0J
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50228417
PNG
(CHEMBL238491 | diphenyl 1-(o-toluenesulfonylamino)...)
Show SMILES NC(N)=Nc1ccc(CC(NS(=O)(=O)Cc2ccccc2)P(=O)(Oc2ccccc2)Oc2ccccc2)cc1
Show InChI InChI=1S/C28H29N4O5PS/c29-28(30)31-24-18-16-22(17-19-24)20-27(32-39(34,35)21-23-10-4-1-5-11-23)38(33,36-25-12-6-2-7-13-25)37-26-14-8-3-9-15-26/h1-19,27,32H,20-21H2,(H4,29,30,31)
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n/an/a 7.70n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA


J Med Chem 50: 6638-46 (2007)


Article DOI: 10.1021/jm700962j
BindingDB Entry DOI: 10.7270/Q2MW2J0J
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50194733
PNG
(CHEMBL411215 | diphenyl 1-[(N-1-adamantanyl-D-sery...)
Show SMILES C[C@H](NC(=O)[C@@H](CO)NC(=O)C1C2CC3CC(C2)CC1C3)C(=O)NC(Cc1ccc(NC(N)=N)cc1)P(=O)(Oc1ccccc1)Oc1ccccc1
Show InChI InChI=1S/C38H47N6O7P/c1-23(41-36(47)32(22-45)43-37(48)34-27-17-25-16-26(19-27)20-28(34)18-25)35(46)44-33(21-24-12-14-29(15-13-24)42-38(39)40)52(49,50-30-8-4-2-5-9-30)51-31-10-6-3-7-11-31/h2-15,23,25-28,32-34,45H,16-22H2,1H3,(H,41,47)(H,43,48)(H,44,46)(H4,39,40,42)/t23-,25?,26?,27?,28?,32+,33?,34?/m0/s1
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n/an/a 8n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA


J Med Chem 49: 5785-93 (2006)


Article DOI: 10.1021/jm060622g
BindingDB Entry DOI: 10.7270/Q2SF2VT3
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50228423
PNG
(CHEMBL239536 | ethyl 1-(diphenoxyphosphoryl)-2-(4-...)
Show SMILES CCOC(=O)NC(Cc1ccc(cc1)N=C(N)N)P(=O)(Oc1ccccc1)Oc1ccccc1
Show InChI InChI=1S/C24H27N4O5P/c1-2-31-24(29)28-22(17-18-13-15-19(16-14-18)27-23(25)26)34(30,32-20-9-5-3-6-10-20)33-21-11-7-4-8-12-21/h3-16,22H,2,17H2,1H3,(H,28,29)(H4,25,26,27)
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n/an/a 8n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA


J Med Chem 50: 6638-46 (2007)


Article DOI: 10.1021/jm700962j
BindingDB Entry DOI: 10.7270/Q2MW2J0J
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50088984
PNG
(2-Benzenesulfonylamino-N-[1-(1-carbamimidoyl-2-hyd...)
Show SMILES C[C@H](NC(=O)[C@@H](CO)NS(=O)(=O)c1ccccc1)C(=O)N[C@H]1CCCN(C1O)C(N)=N
Show InChI InChI=1S/C18H28N6O6S/c1-11(15(26)22-13-8-5-9-24(17(13)28)18(19)20)21-16(27)14(10-25)23-31(29,30)12-6-3-2-4-7-12/h2-4,6-7,11,13-14,17,23,25,28H,5,8-10H2,1H3,(H3,19,20)(H,21,27)(H,22,26)/t11-,13-,14+,17?/m0/s1
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n/an/a 10n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
The compound was tested in vitro for its inhibitory activity against human urokinase enzyme, activity expressed as IC50


Bioorg Med Chem Lett 10: 983-7 (2000)


Article DOI: 10.1016/s0960-894x(00)00149-9
BindingDB Entry DOI: 10.7270/Q2765DKB
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM92485
PNG
(CDE-066 | US9120744, CDE-066)
Show SMILES Oc1cc(cc(O)c1O)C(=O)OC[C@H]1OC(OC(=O)c2cc(O)c(O)c(O)c2)[C@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@@H](OC(=O)c2cc(O)c(O)c(O)c2)[C@H]1OC(=O)c1cc(O)c(O)c(O)c1
Show InChI InChI=1S/C41H32O26/c42-17-1-12(2-18(43)28(17)52)36(57)62-11-27-33(64-37(58)13-3-19(44)29(53)20(45)4-13)34(65-38(59)14-5-21(46)30(54)22(47)6-14)35(66-39(60)15-7-23(48)31(55)24(49)8-15)41(63-27)67-40(61)16-9-25(50)32(56)26(51)10-16/h1-10,27,33-35,41-56H,11H2/t27-,33+,34+,35-,41?/m1/s1
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n/an/a 10n/an/an/an/a7.823



University of Michigan



Assay Description
Enzyme activity assay using human and murine PAI-1.


J Biol Chem 285: 7892-902 (2010)


Article DOI: 10.1074/jbc.M109.067967
BindingDB Entry DOI: 10.7270/Q2ZC81FC
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50088979
PNG
(CHEMBL366666 | {(R)-2-[2-((S)-1-Carbamimidoyl-2-hy...)
Show SMILES NC(=N)N1CCC[C@H](NC(=O)C2CCN2C(=O)[C@@H](CO)NC(=O)OCc2ccccc2)C1O
Show InChI InChI=1S/C21H30N6O6/c22-20(23)27-9-4-7-14(18(27)30)24-17(29)16-8-10-26(16)19(31)15(11-28)25-21(32)33-12-13-5-2-1-3-6-13/h1-3,5-6,14-16,18,28,30H,4,7-12H2,(H3,22,23)(H,24,29)(H,25,32)/t14-,15+,16?,18?/m0/s1
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n/an/a 11n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
The compound was tested in vitro for its inhibitory activity against human urokinase enzyme, activity expressed as IC50


Bioorg Med Chem Lett 10: 983-7 (2000)


Article DOI: 10.1016/s0960-894x(00)00149-9
BindingDB Entry DOI: 10.7270/Q2765DKB
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50088985
PNG
(CHEMBL369042 | {2-[2-(1-Carbamimidoyl-2-hydroxy-pi...)
Show SMILES NC(=N)N1CCCC(NC(=O)[C@H]2CCCN2C(=O)C(CO)NC(=O)OCc2ccccc2)C1O
Show InChI InChI=1S/C22H32N6O6/c23-21(24)28-11-4-8-15(19(28)31)25-18(30)17-9-5-10-27(17)20(32)16(12-29)26-22(33)34-13-14-6-2-1-3-7-14/h1-3,6-7,15-17,19,29,31H,4-5,8-13H2,(H3,23,24)(H,25,30)(H,26,33)/t15?,16?,17-,19?/m1/s1
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n/an/a 12n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
The compound was tested in vitro for its inhibitory activity against human urokinase enzyme, activity expressed as IC50


Bioorg Med Chem Lett 10: 983-7 (2000)


Article DOI: 10.1016/s0960-894x(00)00149-9
BindingDB Entry DOI: 10.7270/Q2765DKB
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM92486
PNG
(CDE-082 | US9120744, CDE-082)
Show SMILES Oc1cc(cc(O)c1O)C(=O)OCC(COC(=O)c1cc(O)c(O)c(O)c1)OC(=O)c1cc(O)c(O)c(O)c1
Show InChI InChI=1S/C24H20O15/c25-13-1-9(2-14(26)19(13)31)22(34)37-7-12(39-24(36)11-5-17(29)21(33)18(30)6-11)8-38-23(35)10-3-15(27)20(32)16(28)4-10/h1-6,12,25-33H,7-8H2
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n/an/a 14n/an/an/an/a7.823



University of Michigan



Assay Description
Enzyme activity assay using human and murine PAI-1.


J Biol Chem 285: 7892-902 (2010)


Article DOI: 10.1074/jbc.M109.067967
BindingDB Entry DOI: 10.7270/Q2ZC81FC
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50301972
PNG
(2-(6-(5-amino-3'-(aminomethyl)biphenyl-3-yloxy)-4-...)
Show SMILES CN(C)C1CCN(C1)c1c(F)c(Oc2cc(N)cc(c2)-c2cccc(CN)c2)nc(Oc2cc(C)ccc2C(O)=O)c1F
Show InChI InChI=1S/C32H33F2N5O4/c1-18-7-8-25(32(40)41)26(11-18)43-31-28(34)29(39-10-9-23(17-39)38(2)3)27(33)30(37-31)42-24-14-21(13-22(36)15-24)20-6-4-5-19(12-20)16-35/h4-8,11-15,23H,9-10,16-17,35-36H2,1-3H3,(H,40,41)
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n/an/a 15n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of uPA


Bioorg Med Chem Lett 19: 5712-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.008
BindingDB Entry DOI: 10.7270/Q2JQ113Z
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50088977
PNG
(CHEMBL177557 | {1-[1-(1-Carbamimidoyl-2-hydroxy-pi...)
Show SMILES C[C@H](NC(=O)[C@@H](CO)NC(=O)OCc1ccccc1)C(=O)N[C@H]1CCCN(C1O)C(N)=N
Show InChI InChI=1S/C20H30N6O6/c1-12(16(28)24-14-8-5-9-26(18(14)30)19(21)22)23-17(29)15(10-27)25-20(31)32-11-13-6-3-2-4-7-13/h2-4,6-7,12,14-15,18,27,30H,5,8-11H2,1H3,(H3,21,22)(H,23,29)(H,24,28)(H,25,31)/t12-,14-,15+,18?/m0/s1
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n/an/a 19n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
The compound was tested in vitro for its inhibitory activity against human urokinase enzyme, activity expressed as IC50


Bioorg Med Chem Lett 10: 983-7 (2000)


Article DOI: 10.1016/s0960-894x(00)00149-9
BindingDB Entry DOI: 10.7270/Q2765DKB
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50231520
PNG
((R)-N-[(S)-1-(4-carbamimidoyl-benzylcarbamoyl)-2-h...)
Show SMILES NC(=N)c1ccc(CNC(=O)[C@H](CO)NC(=O)[C@@H](CO)NS(=O)(=O)Cc2ccccc2)cc1
Show InChI InChI=1S/C21H27N5O6S/c22-19(23)16-8-6-14(7-9-16)10-24-20(29)17(11-27)25-21(30)18(12-28)26-33(31,32)13-15-4-2-1-3-5-15/h1-9,17-18,26-28H,10-13H2,(H3,22,23)(H,24,29)(H,25,30)/t17-,18+/m0/s1
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n/an/a 20n/an/an/an/an/an/a



Astex Therapeutics Ltd

Curated by ChEMBL


Assay Description
Inhibition of uPA


J Med Chem 51: 183-6 (2008)


Article DOI: 10.1021/jm701359z
BindingDB Entry DOI: 10.7270/Q2XG9QWK
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM92487
PNG
(CDE-031 | US9120744, CDE-031)
Show SMILES Oc1cc(cc(O)c1O)C(=O)O[C@@H]1CCCC[C@@H]1OC(=O)c1cc(O)c(O)c(O)c1
Show InChI InChI=1S/C20H20O10/c21-11-5-9(6-12(22)17(11)25)19(27)29-15-3-1-2-4-16(15)30-20(28)10-7-13(23)18(26)14(24)8-10/h5-8,15-16,21-26H,1-4H2/t15-,16+
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n/an/a 20n/an/an/an/a7.823



University of Michigan



Assay Description
Enzyme activity assay using human and murine PAI-1.


J Biol Chem 285: 7892-902 (2010)


Article DOI: 10.1074/jbc.M109.067967
BindingDB Entry DOI: 10.7270/Q2ZC81FC
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50088987
PNG
(CHEMBL174813 | {1-[1-(1-Carbamimidoyl-2-hydroxy-pi...)
Show SMILES CC(C)COC(=O)N[C@H](CO)C(=O)N[C@@H](C)C(=O)N[C@H]1CCCN(C1O)C(N)=N
Show InChI InChI=1S/C17H32N6O6/c1-9(2)8-29-17(28)22-12(7-24)14(26)20-10(3)13(25)21-11-5-4-6-23(15(11)27)16(18)19/h9-12,15,24,27H,4-8H2,1-3H3,(H3,18,19)(H,20,26)(H,21,25)(H,22,28)/t10-,11-,12+,15?/m0/s1
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n/an/a 23n/an/an/an/an/an/a



Corvas International, Inc.

Curated by ChEMBL


Assay Description
The compound was tested in vitro for its inhibitory activity against human urokinase enzyme, activity expressed as IC50


Bioorg Med Chem Lett 10: 983-7 (2000)


Article DOI: 10.1016/s0960-894x(00)00149-9
BindingDB Entry DOI: 10.7270/Q2765DKB
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50301973
PNG
(2-(6-(3'-(aminomethyl)-5-hydroxybiphenyl-3-yloxy)-...)
Show SMILES Cc1ccc(C(O)=O)c(Oc2nc(Oc3cc(O)cc(c3)-c3cccc(CN)c3)c(F)cc2F)c1
Show InChI InChI=1S/C26H20F2N2O5/c1-14-5-6-20(26(32)33)23(7-14)35-25-22(28)12-21(27)24(30-25)34-19-10-17(9-18(31)11-19)16-4-2-3-15(8-16)13-29/h2-12,31H,13,29H2,1H3,(H,32,33)
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n/an/a 23n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of uPA


Bioorg Med Chem Lett 19: 5712-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.008
BindingDB Entry DOI: 10.7270/Q2JQ113Z
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50301982
PNG
(2-(6-(3'-(aminomethyl)biphenyl-3-yloxy)-4-(3-(dime...)
Show SMILES CN(C)C1CCN(C1)c1c(F)c(Oc2cccc(c2)-c2cccc(CN)c2)nc(Oc2cc(ccc2C(O)=O)N(C)C)c1F
Show InChI InChI=1S/C33H35F2N5O4/c1-38(2)23-11-12-26(33(41)42)27(17-23)44-32-29(35)30(40-14-13-24(19-40)39(3)4)28(34)31(37-32)43-25-10-6-9-22(16-25)21-8-5-7-20(15-21)18-36/h5-12,15-17,24H,13-14,18-19,36H2,1-4H3,(H,41,42)
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n/an/a 25n/an/an/an/an/an/a



Berlex Biosciences

Curated by ChEMBL


Assay Description
Inhibition of uPA


Bioorg Med Chem Lett 19: 5712-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.08.008
BindingDB Entry DOI: 10.7270/Q2JQ113Z
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50184648
PNG
(CHEMBL378976 | [benzyloxycarbonylamino-(4-guanidin...)
Show SMILES CSc1ccc(OP(=O)(Oc2ccc(SC)cc2)C(NC(=O)OCc2ccccc2)c2ccc(cc2)N=C(N)N)cc1
Show InChI InChI=1S/C30H31N4O5PS2/c1-41-26-16-12-24(13-17-26)38-40(36,39-25-14-18-27(42-2)19-15-25)28(22-8-10-23(11-9-22)33-29(31)32)34-30(35)37-20-21-6-4-3-5-7-21/h3-19,28H,20H2,1-2H3,(H,34,35)(H4,31,32,33)
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n/an/a 26n/an/an/an/an/an/a



Wroc£?aw University of Technology

Curated by ChEMBL


Assay Description
Inhibition of human uPA by chromogenic assay using Cbz-Val-Gly-Arg-pNA as chromogenic substrate


Bioorg Med Chem Lett 16: 2886-90 (2006)


Article DOI: 10.1016/j.bmcl.2006.03.002
BindingDB Entry DOI: 10.7270/Q22N51WR
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50228426
PNG
(CHEMBL391344 | diphenyl 1-(naphthalenesulfonylamin...)
Show SMILES NC(N)=Nc1ccc(CC(NS(=O)(=O)c2cccc3ccccc23)P(=O)(Oc2ccccc2)Oc2ccccc2)cc1
Show InChI InChI=1S/C31H29N4O5PS/c32-31(33)34-25-20-18-23(19-21-25)22-30(35-42(37,38)29-17-9-11-24-10-7-8-16-28(24)29)41(36,39-26-12-3-1-4-13-26)40-27-14-5-2-6-15-27/h1-21,30,35H,22H2,(H4,32,33,34)
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n/an/a 26.5n/an/an/an/an/an/a



University of Antwerp

Curated by ChEMBL


Assay Description
Inhibition of human uPA


J Med Chem 50: 6638-46 (2007)


Article DOI: 10.1021/jm700962j
BindingDB Entry DOI: 10.7270/Q2MW2J0J
More data for this
Ligand-Target Pair
PAI-1/uPA


(Homo sapiens (Human))
BDBM264615
PNG
(US9718760, C182)
Show SMILES CCCCCCCN(S(=O)(=O)c1ccc(O)c(O)c1)S(=O)(=O)c1ccc(O)c(O)c1
Show InChI InChI=1S/C19H25NO8S2/c1-2-3-4-5-6-11-20(29(25,26)14-7-9-16(21)18(23)12-14)30(27,28)15-8-10-17(22)19(24)13-15/h7-10,12-13,21-24H,2-6,11H2,1H3
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US Patent
n/an/a 33n/an/an/an/a7.425



THE REGENTS OF THE UNIVERSITY OF MICHIGAN; EASTERN MICHIGAN UNIVERSITY

US Patent


Assay Description
To determine the efficacy of various synthesized compounds as PAI-1 inhibitors, a fluorometric plate assay was carried out to measure the half maxima...


US Patent US9718760 (2017)

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Ligand-Target Pair
Urokinase-type plasminogen activator


(Homo sapiens (Human))
BDBM50144551
PNG
((2S,3R)-1-(4-tert-Butylcarbamoyl-piperazine-1-carb...)
Show SMILES CC(C)(C)NC(=O)N1CCN(CC1)C(=O)N1[C@@H]([C@@H](CC2CCNCC2)C1=O)C(O)=O
Show InChI InChI=1S/C20H33N5O5/c1-20(2,3)22-18(29)23-8-10-24(11-9-23)19(30)25-15(17(27)28)14(16(25)26)12-13-4-6-21-7-5-13/h13-15,21H,4-12H2,1-3H3,(H,22,29)(H,27,28)/t14-,15+/m1/s1
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n/an/a 34n/an/an/an/an/an/a



The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against Urokinase-type plasminogen activator


Bioorg Med Chem Lett 14: 2233-9 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.012
BindingDB Entry DOI: 10.7270/Q2SB4697
More data for this
Ligand-Target Pair
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