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Compile Data Set for Download or QSAR

Found 8 hits of kd for UniProtKB: P00749   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Urokinase-type plasminogen activator/surface receptor


(Homo sapiens (Human))
BDBM50003742
PNG
((Lactone1)N-[4-(6-Methylene-2-oxo-tetrahydro-pyran...)
Show SMILES NC(=N)NCc1ccc(cc1)C1CCC(=C)OC1=O
Show InChI InChI=1S/C14H17N3O2/c1-9-2-7-12(13(18)19-9)11-5-3-10(4-6-11)8-17-14(15)16/h3-6,12H,1-2,7-8H2,(H4,15,16,17)
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Article
PubMed
n/an/an/a 0.0440n/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Compound was tested for the rate constant of deacylation against the enzyme Urokinase-type plasminogen activator


J Med Chem 35: 4297-305 (1992)


Article DOI: 10.1021/jm00101a006
BindingDB Entry DOI: 10.7270/Q2TD9W9D
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator/surface receptor


(Homo sapiens (Human))
BDBM50003740
PNG
((Lactone IIa)N-[4-(2-Methylene-6-oxo-tetrahydro-py...)
Show SMILES NC(N)=Nc1ccc(cc1)C1CC(=C)OC(=O)C1
Show InChI InChI=1S/C13H15N3O2/c1-8-6-10(7-12(17)18-8)9-2-4-11(5-3-9)16-13(14)15/h2-5,10H,1,6-7H2,(H4,14,15,16)
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Article
PubMed
n/an/an/a 0.00900n/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Decylation rate constant against Urokinase-type plasminogen activator


J Med Chem 35: 4150-9 (1992)


Article DOI: 10.1021/jm00100a021
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator/surface receptor


(Homo sapiens (Human))
BDBM50003737
PNG
((Lactone4)N-[4-(4-Guanidino-phenyl)-6-iodomethylen...)
Show SMILES NC(N)=Nc1ccc(cc1)C1C\C(OC(=O)C1NC(=O)c1ccccc1)=C\I
Show InChI InChI=1S/C20H19IN4O3/c21-11-15-10-16(12-6-8-14(9-7-12)24-20(22)23)17(19(27)28-15)25-18(26)13-4-2-1-3-5-13/h1-9,11,16-17H,10H2,(H,25,26)(H4,22,23,24)/b15-11-
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n/an/an/a 0.00500n/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Compound was tested for the rate constant of deacylation against the enzyme Urokinase-type plasminogen activator


J Med Chem 35: 4297-305 (1992)


Article DOI: 10.1021/jm00101a006
BindingDB Entry DOI: 10.7270/Q2TD9W9D
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator/surface receptor


(Homo sapiens (Human))
BDBM50212459
PNG
(CHEMBL1159958)
Show SMILES NC(=N)Nc1ccc(cc1)C1CC(=C)OC(=C)C1
Show InChI InChI=1S/C14H17N3O/c1-9-7-12(8-10(2)18-9)11-3-5-13(6-4-11)17-14(15)16/h3-6,12H,1-2,7-8H2,(H4,15,16,17)
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n/an/an/a 0.00900n/an/an/an/an/a


TBA

Assay Description
Rate constant of deacylation for Urokinase-type plasminogen activator


Citation and Details
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator/surface receptor


(Homo sapiens (Human))
BDBM50003740
PNG
((Lactone IIa)N-[4-(2-Methylene-6-oxo-tetrahydro-py...)
Show SMILES NC(N)=Nc1ccc(cc1)C1CC(=C)OC(=O)C1
Show InChI InChI=1S/C13H15N3O2/c1-8-6-10(7-12(17)18-8)9-2-4-11(5-3-9)16-13(14)15/h2-5,10H,1,6-7H2,(H4,14,15,16)
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Article
PubMed
n/an/an/a 0.00900n/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Compound was tested for the rate constant of deacylation against Urokinase-type plasminogen activator


J Med Chem 35: 4297-305 (1992)


Article DOI: 10.1021/jm00101a006
BindingDB Entry DOI: 10.7270/Q2TD9W9D
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator/surface receptor


(Homo sapiens (Human))
BDBM50212460
PNG
(CHEMBL1159951)
Show SMILES NC(=N)Nc1ccc(cc1)[C@H]1C\C(OC(=C)[C@@H]1NC(=O)c1ccccc1)=C/I
Show InChI InChI=1S/C21H21IN4O2/c1-13-19(26-20(27)15-5-3-2-4-6-15)18(11-17(12-22)28-13)14-7-9-16(10-8-14)25-21(23)24/h2-10,12,18-19H,1,11H2,(H,26,27)(H4,23,24,25)/b17-12+/t18-,19+/m1/s1
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n/an/an/a 0.000800n/an/an/an/an/a


TBA

Assay Description
Rate constant of deacylation for Urokinase-type plasminogen activator


Citation and Details
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator/surface receptor


(Homo sapiens (Human))
BDBM50003742
PNG
((Lactone1)N-[4-(6-Methylene-2-oxo-tetrahydro-pyran...)
Show SMILES NC(=N)NCc1ccc(cc1)C1CCC(=C)OC1=O
Show InChI InChI=1S/C14H17N3O2/c1-9-2-7-12(13(18)19-9)11-5-3-10(4-6-11)8-17-14(15)16/h3-6,12H,1-2,7-8H2,(H4,15,16,17)
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n/an/an/a 0.0440n/an/an/an/an/a


TBA

Assay Description
Rate constant of deacylation for Urokinase-type plasminogen activator


Citation and Details
More data for this
Ligand-Target Pair
Urokinase-type plasminogen activator/surface receptor


(Homo sapiens (Human))
BDBM50003739
PNG
((Lactone3)N-[4-(4-Guanidino-phenyl)-6-methylene-2-...)
Show SMILES NC(N)=Nc1ccc(cc1)C1CC(=C)OC(=O)C1NC(=O)c1ccccc1
Show InChI InChI=1S/C20H20N4O3/c1-12-11-16(13-7-9-15(10-8-13)23-20(21)22)17(19(26)27-12)24-18(25)14-5-3-2-4-6-14/h2-10,16-17H,1,11H2,(H,24,25)(H4,21,22,23)
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Article
PubMed
n/an/an/a 0.00200n/an/an/an/an/a



University of Illinois

Curated by ChEMBL


Assay Description
Compound was tested for its binding affinity against the enzyme Urokinase-type plasminogen activator


J Med Chem 35: 4297-305 (1992)


Article DOI: 10.1021/jm00101a006
BindingDB Entry DOI: 10.7270/Q2TD9W9D
More data for this
Ligand-Target Pair