BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 9 hits of ic50 data for polymerid = 5288   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cytochrome P450 27B1


(Homo sapiens (Human))
BDBM50261586
PNG
(CHEMBL4099180)
Show SMILES CN(C)CCn1nnnc1SCC(O)(Cn1ccnc1)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C17H21Cl2N7OS/c1-24(2)7-8-26-16(21-22-23-26)28-11-17(27,10-25-6-5-20-12-25)14-4-3-13(18)9-15(14)19/h3-6,9,12,27H,7-8,10-11H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/a 60n/an/an/an/an/an/a



Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of human CYP27B1


Bioorg Med Chem 25: 5629-5636 (2017)

More data for this
Ligand-Target Pair
Cytochrome P450 27B1


(Homo sapiens (Human))
BDBM50261589
PNG
(CHEMBL4081152)
Show SMILES CN(C)c1cccc2c(cccc12)S(=O)(=O)NC(Cn1ccnc1)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C23H22Cl2N4O2S/c1-28(2)22-7-3-6-18-17(22)5-4-8-23(18)32(30,31)27-21(14-29-12-11-26-15-29)19-10-9-16(24)13-20(19)25/h3-13,15,21,27H,14H2,1-2H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/a 95n/an/an/an/an/an/a



Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of human CYP27B1


Bioorg Med Chem 25: 5629-5636 (2017)

More data for this
Ligand-Target Pair
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial


(Homo sapiens (Human))
BDBM151585
PNG
(US8987315, Ketoconazole | US9180183, Ketoconazole ...)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(OCC2COC(Cn3ccnc3)(O2)c2ccc(Cl)cc2Cl)cc1
Show InChI InChI=1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
Purchase

DrugBank
PC cid
PC sid
PDB
UniChem

Similars

PubMed
n/an/a 340n/an/an/an/an/an/a



Cardiff University

Curated by ChEMBL


Assay Description
Displacement of [3H]E2 from GST-fused ERalpha-LBD (unknown origin) expressed in Escherichia coli BL21 incubated for 1 hr by liquid scintillation coun...


Bioorg Med Chem 25: 5629-5636 (2017)

More data for this
Ligand-Target Pair
Cytochrome P450 27B1


(Homo sapiens (Human))
BDBM50261588
PNG
(CHEMBL4074768)
Show SMILES Cc1[nH]nc(O)c1C(c1c(O)n[nH]c1C)c1cccc(OCc2ccncc2)c1
Show InChI InChI=1S/C21H21N5O3/c1-12-17(20(27)25-23-12)19(18-13(2)24-26-21(18)28)15-4-3-5-16(10-15)29-11-14-6-8-22-9-7-14/h3-10,19H,11H2,1-2H3,(H2,23,25,27)(H2,24,26,28)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/a 410n/an/an/an/an/an/a



Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of human CYP27B1 expressed in Escherichia coli assessed as reduction in hydrolase activity incubated for 25 mins using Adx, AdR and 1,25(O...


Bioorg Med Chem 25: 5629-5636 (2017)

More data for this
Ligand-Target Pair
Cytochrome P450 27B1


(Homo sapiens (Human))
BDBM50214607
PNG
(CHEMBL541423 | MK-24 | MK-24(S)-S(O)(NH)Ph)
Show SMILES C[C@H](CC=S(N)(=O)c1ccccc1)C1=CCC2\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C
Show InChI InChI=1S/C29H39NO3S/c1-20(15-17-34(30,33)25-9-5-4-6-10-25)26-13-14-27-22(8-7-16-29(26,27)3)11-12-23-18-24(31)19-28(32)21(23)2/h4-6,9-13,17,20,24,27-28,31-32H,2,7-8,14-16,18-19H2,1,3H3,(H2,30,33)/b22-11+,23-12-/t20-,24-,27?,28+,29-,34?/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 554n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Inhibition of CYP27B1


Bioorg Med Chem 15: 5047-60 (2007)


Article DOI: 10.1016/j.bmc.2007.05.046
BindingDB Entry DOI: 10.7270/Q20R9Q7F
More data for this
Ligand-Target Pair
Cytochrome P450 27B1


(Homo sapiens (Human))
BDBM50370925
PNG
(CHEMBL1627233)
Show SMILES C[C@H](CC=S(N)(=O)c1ccccc1)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C
Show InChI InChI=1S/C29H41NO3S/c1-20(15-17-34(30,33)25-9-5-4-6-10-25)26-13-14-27-22(8-7-16-29(26,27)3)11-12-23-18-24(31)19-28(32)21(23)2/h4-6,9-12,17,20,24,26-28,31-32H,2,7-8,13-16,18-19H2,1,3H3,(H2,30,33)/b22-11+,23-12-/t20-,24-,26-,27+,28+,29-,34?/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 554n/an/an/an/an/an/a



The Johns Hopkins University

Curated by ChEMBL


Assay Description
Inhibition of human CYP27B hydroxylase expressed in SW900 cells


J Med Chem 47: 6854-63 (2004)


Article DOI: 10.1021/jm040129+
BindingDB Entry DOI: 10.7270/Q2ZW1MRZ
More data for this
Ligand-Target Pair
Cytochrome P450 27B1


(Homo sapiens (Human))
BDBM50261587
PNG
(CHEMBL4104395)
Show SMILES Cc1[nH]nc(O)c1C(c1c(O)n[nH]c1C)c1ccc(OCc2ccncc2)cc1
Show InChI InChI=1S/C21H21N5O3/c1-12-17(20(27)25-23-12)19(18-13(2)24-26-21(18)28)15-3-5-16(6-4-15)29-11-14-7-9-22-10-8-14/h3-10,19H,11H2,1-2H3,(H2,23,25,27)(H2,24,26,28)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

PubMed
n/an/a 570n/an/an/an/an/an/a



Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of human CYP27B1 expressed in Escherichia coli assessed as reduction in hydrolase activity incubated for 25 mins using Adx, AdR and 1,25(O...


Bioorg Med Chem 25: 5629-5636 (2017)

More data for this
Ligand-Target Pair
Cytochrome P450 27B1


(Homo sapiens (Human))
BDBM50214606
PNG
(4'-chloro-biphenyl-4-carboxylic acid (2-imidazol-1...)
Show SMILES Clc1ccc(cc1)-c1ccc(cc1)C(=O)NCC(c1ccccc1)n1ccnc1
Show InChI InChI=1S/C24H20ClN3O/c25-22-12-10-19(11-13-22)18-6-8-21(9-7-18)24(29)27-16-23(28-15-14-26-17-28)20-4-2-1-3-5-20/h1-15,17,23H,16H2,(H,27,29)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 616n/an/an/an/an/an/a



University of Maryland

Curated by ChEMBL


Assay Description
Inhibition of CYP27B1 in human keratinocytes


Bioorg Med Chem 15: 5047-60 (2007)


Article DOI: 10.1016/j.bmc.2007.05.046
BindingDB Entry DOI: 10.7270/Q20R9Q7F
More data for this
Ligand-Target Pair
Cytochrome P450 27B1


(Homo sapiens (Human))
BDBM50322358
PNG
(4'-Chloro-biphenyl-4-carboxylic acid((R)-2-imidazo...)
Show SMILES Clc1ccc(cc1)-c1ccc(cc1)C(=O)NC[C@@H](c1ccccc1)n1ccnc1
Show InChI InChI=1S/C24H20ClN3O/c25-22-12-10-19(11-13-22)18-6-8-21(9-7-18)24(29)27-16-23(28-15-14-26-17-28)20-4-2-1-3-5-20/h1-15,17,23H,16H2,(H,27,29)/t23-/m0/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

PubMed
n/an/a 616n/an/an/an/an/an/a



Cardiff University

Curated by ChEMBL


Assay Description
Inhibition of human CYP27B1


Bioorg Med Chem 25: 5629-5636 (2017)

More data for this
Ligand-Target Pair