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Compile Data Set for Download or QSAR

Found 10 hits of ki for UniProtKB: P05696   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM25524
PNG
(17,18-dimethoxy-21-methyl-5,7-dioxa-21-azapentacyc...)
Show SMILES COc1ccc2c(c[n+](C)c3c4cc5OCOc5cc4ccc23)c1OC
Show InChI InChI=1S/C21H18NO4/c1-22-10-16-13(6-7-17(23-2)21(16)24-3)14-5-4-12-8-18-19(26-11-25-18)9-15(12)20(14)22/h4-10H,11H2,1-3H3/q+1
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660n/an/an/an/an/an/an/an/a



Temple University

Curated by PDSP Ki Database




J Pharmacol Exp Ther 316: 869-74 (2006)


Article DOI: 10.1124/jpet.105.097303
BindingDB Entry DOI: 10.7270/Q2PN9464
More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM50280897
PNG
(CHEMBL281660 | Tetradecanoic acid (2S,3R)-2-(2-hyd...)
Show SMILES CCCCCCCCCCCCCC(=O)O[C@@H]1CC(=O)O[C@H]1CCO
Show InChI InChI=1S/C20H36O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-19(22)25-18-16-20(23)24-17(18)14-15-21/h17-18,21H,2-16H2,1H3/t17-,18+/m0/s1
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Article
880n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PDBU binding to Protein kinase C alpha


Bioorg Med Chem Lett 4: 1369-1374 (1994)


Article DOI: 10.1016/S0960-894X(01)80364-4
BindingDB Entry DOI: 10.7270/Q2V98818
More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM50282658
PNG
(((2R,3R)-2-Hydroxymethyl-5-oxo-tetrahydro-furan-3-...)
Show SMILES CCCCCCCCCCCCCCOC(=O)C[C@@H]1CC(=O)O[C@H]1CO
Show InChI InChI=1S/C21H38O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-25-20(23)15-18-16-21(24)26-19(18)17-22/h18-19,22H,2-17H2,1H3/t18-,19+/m1/s1
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1.47E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PDBU binding to Protein kinase C alpha


Bioorg Med Chem Lett 4: 1369-1374 (1994)


Article DOI: 10.1016/S0960-894X(01)80364-4
BindingDB Entry DOI: 10.7270/Q2V98818
More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM50280896
PNG
(CHEMBL276429 | Tetradecanoic acid (2S,3R)-2-hydrox...)
Show SMILES CCCCCCCCCCCCCC(=O)O[C@@H]1CC(=O)O[C@H]1CO
Show InChI InChI=1S/C19H34O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-18(21)23-16-14-19(22)24-17(16)15-20/h16-17,20H,2-15H2,1H3/t16-,17+/m1/s1
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1.50E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PDBU binding to Protein kinase C alpha


Bioorg Med Chem Lett 4: 1369-1374 (1994)


Article DOI: 10.1016/S0960-894X(01)80364-4
BindingDB Entry DOI: 10.7270/Q2V98818
More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM50282661
PNG
(CHEMBL29762 | Tetradecanoic acid (2R,3S)-2-hydroxy...)
Show SMILES CCCCCCCCCCCCCC(=O)OC[C@@H]1CC(=O)O[C@H]1CO
Show InChI InChI=1S/C20H36O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-19(22)24-16-17-14-20(23)25-18(17)15-21/h17-18,21H,2-16H2,1H3/t17-,18-/m0/s1
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3.10E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PDBU binding to Protein kinase C alpha


Bioorg Med Chem Lett 4: 1369-1374 (1994)


Article DOI: 10.1016/S0960-894X(01)80364-4
BindingDB Entry DOI: 10.7270/Q2V98818
More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM86727
PNG
(1-(5-isoquinolinesulfonyl)-2-methylpiperazine.2HCl...)
Show SMILES CC1CN(CCN1)S(=O)(=O)c1cccc2cnccc12
Show InChI InChI=1S/C14H17N3O2S/c1-11-10-17(8-7-16-11)20(18,19)14-4-2-3-12-9-15-6-5-13(12)14/h2-6,9,11,16H,7-8,10H2,1H3
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6.00E+3n/an/an/an/an/an/an/an/a



Temple University

Curated by PDSP Ki Database




J Pharmacol Exp Ther 316: 869-74 (2006)


Article DOI: 10.1124/jpet.105.097303
BindingDB Entry DOI: 10.7270/Q2PN9464
More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM86729
PNG
((R)-(+)-trans-4-(1-aminoethyl)-N-(4-pyridyl)cycloh...)
Show SMILES C[C@@H](N)[C@H]1CC[C@@H](CC1)C(=O)Nc1ccncc1
Show InChI InChI=1S/C14H21N3O/c1-10(15)11-2-4-12(5-3-11)14(18)17-13-6-8-16-9-7-13/h6-12H,2-5,15H2,1H3,(H,16,17,18)/t10-,11-,12-/m1/s1
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>1.00E+4n/an/an/an/an/an/an/an/a



Temple University

Curated by PDSP Ki Database




J Pharmacol Exp Ther 316: 869-74 (2006)


Article DOI: 10.1124/jpet.105.097303
BindingDB Entry DOI: 10.7270/Q2PN9464
More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM50009723
PNG
(2,6-Diamino-hexanoic acid (1-tridecanoyl-piperidin...)
Show SMILES CCCCCCCCCCCCC(=O)N1CCCCC1CNC(=O)[C@@H](N)CCCCN
Show InChI InChI=1S/C25H50N4O2/c1-2-3-4-5-6-7-8-9-10-11-18-24(30)29-20-15-13-16-22(29)21-28-25(31)23(27)17-12-14-19-26/h22-23H,2-21,26-27H2,1H3,(H,28,31)/t22?,23-/m0/s1
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1.20E+4n/an/an/an/an/an/an/an/a



Nova Pharmaceutical Corporation

Curated by ChEMBL


Assay Description
Effect of Phosphatidylserine on inhibition of Protein kinase C alpha


J Med Chem 34: 2928-31 (1991)


Article DOI: 10.1021/jm00113a038
BindingDB Entry DOI: 10.7270/Q2KH0NZG
More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM50282657
PNG
(CHEMBL29668 | [(2S,3R)-2-(2-Hydroxy-ethyl)-5-oxo-t...)
Show SMILES CCCCCCCCCCCCCCOC(=O)C[C@@H]1CC(=O)O[C@H]1CCO
Show InChI InChI=1S/C22H40O5/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-26-21(24)17-19-18-22(25)27-20(19)14-15-23/h19-20,23H,2-18H2,1H3/t19-,20+/m1/s1
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1.86E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of [3H]-PDBU binding to Protein kinase C alpha


Bioorg Med Chem Lett 4: 1369-1374 (1994)


Article DOI: 10.1016/S0960-894X(01)80364-4
BindingDB Entry DOI: 10.7270/Q2V98818
More data for this
Ligand-Target Pair
Protein kinase C alpha


(Rattus norvegicus (Rat))
BDBM50283971
PNG
(CHEMBL153171 | Tetradecanoic acid (2S,3R)-2-hydrox...)
Show SMILES CCCCCCCCCCCCCC(=O)O[C@@H]1CCCC(=O)O[C@H]1CO
Show InChI InChI=1S/C21H38O5/c1-2-3-4-5-6-7-8-9-10-11-12-15-20(23)25-18-14-13-16-21(24)26-19(18)17-22/h18-19,22H,2-17H2,1H3/t18-,19+/m1/s1
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4.10E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Displacement of [3H]-phorbol-12,13-dibutyrate from rat brain protein kinase C alpha


Bioorg Med Chem Lett 4: 543-548 (1994)


Article DOI: 10.1016/S0960-894X(01)80151-7
BindingDB Entry DOI: 10.7270/Q23B6025
More data for this
Ligand-Target Pair