BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 85 hits of ic50 data for polymerid = 5413   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM101734
PNG
(US9695160, 31 | US9796707, Compound 31)
Show SMILES CSc1nccc(CN2CCN(CC2)c2ccc(cc2NC(=O)c2ccc(C)o2)C(F)(F)F)n1
Show InChI InChI=1S/C23H24F3N5O2S/c1-15-3-6-20(33-15)21(32)29-18-13-16(23(24,25)26)4-5-19(18)31-11-9-30(10-12-31)14-17-7-8-27-22(28-17)34-2/h3-8,13H,9-12,14H2,1-2H3,(H,29,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
US Patent
n/an/a 1.90n/an/an/an/an/an/a



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9796707 (2017)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2125VTM
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101734
PNG
(US9695160, 31 | US9796707, Compound 31)
Show SMILES CSc1nccc(CN2CCN(CC2)c2ccc(cc2NC(=O)c2ccc(C)o2)C(F)(F)F)n1
Show InChI InChI=1S/C23H24F3N5O2S/c1-15-3-6-20(33-15)21(32)29-18-13-16(23(24,25)26)4-5-19(18)31-11-9-30(10-12-31)14-17-7-8-27-22(28-17)34-2/h3-8,13H,9-12,14H2,1-2H3,(H,29,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 1.90n/an/an/an/an/a30



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9695160 (2017)


BindingDB Entry DOI: 10.7270/Q2639MW1
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM101825
PNG
(US9695160, 39 | US9796707, Compound 39)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccccn3)CC2)c(NC(=O)c2ccc(o2)C2CCOCC2)c1
Show InChI InChI=1S/C27H29F3N4O3/c28-27(29,30)20-4-5-23(34-13-11-33(12-14-34)18-21-3-1-2-10-31-21)22(17-20)32-26(35)25-7-6-24(37-25)19-8-15-36-16-9-19/h1-7,10,17,19H,8-9,11-16,18H2,(H,32,35)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
US Patent
n/an/a 2.60n/an/an/an/an/an/a



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9796707 (2017)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2125VTM
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101825
PNG
(US9695160, 39 | US9796707, Compound 39)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccccn3)CC2)c(NC(=O)c2ccc(o2)C2CCOCC2)c1
Show InChI InChI=1S/C27H29F3N4O3/c28-27(29,30)20-4-5-23(34-13-11-33(12-14-34)18-21-3-1-2-10-31-21)22(17-20)32-26(35)25-7-6-24(37-25)19-8-15-36-16-9-19/h1-7,10,17,19H,8-9,11-16,18H2,(H,32,35)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 2.60n/an/an/an/an/a30



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9695160 (2017)


BindingDB Entry DOI: 10.7270/Q2639MW1
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM221074
PNG
(SPHINX31 | US9695160, 12 | US9796707, Compound 12)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccccn3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C27H24F3N5O2/c28-27(29,30)20-4-5-23(35-15-13-34(14-16-35)18-21-3-1-2-10-32-21)22(17-20)33-26(36)25-7-6-24(37-25)19-8-11-31-12-9-19/h1-12,17H,13-16,18H2,(H,33,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
PDB
UniChem
PDB
Article
US Patent
n/an/a 3.18n/an/an/an/an/an/a



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9796707 (2017)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2125VTM
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM221074
PNG
(SPHINX31 | US9695160, 12 | US9796707, Compound 12)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccccn3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C27H24F3N5O2/c28-27(29,30)20-4-5-23(35-15-13-34(14-16-35)18-21-3-1-2-10-32-21)22(17-20)33-26(36)25-7-6-24(37-25)19-8-11-31-12-9-19/h1-12,17H,13-16,18H2,(H,33,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
PDB
UniChem
PDB
US Patent
n/an/a 3.18n/an/an/an/an/a30



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9695160 (2017)


BindingDB Entry DOI: 10.7270/Q2639MW1
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM101676
PNG
(US9695160, 20 | US9796707, Compound 20)
Show SMILES Cc1ccc(o1)C(=O)Nc1cc(ccc1N1CCN(Cc2ccccc2)CC1)C(F)(F)F
Show InChI InChI=1S/C24H24F3N3O2/c1-17-7-10-22(32-17)23(31)28-20-15-19(24(25,26)27)8-9-21(20)30-13-11-29(12-14-30)16-18-5-3-2-4-6-18/h2-10,15H,11-14,16H2,1H3,(H,28,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
US Patent
n/an/a 4.40n/an/an/an/an/an/a



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9796707 (2017)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2125VTM
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101676
PNG
(US9695160, 20 | US9796707, Compound 20)
Show SMILES Cc1ccc(o1)C(=O)Nc1cc(ccc1N1CCN(Cc2ccccc2)CC1)C(F)(F)F
Show InChI InChI=1S/C24H24F3N3O2/c1-17-7-10-22(32-17)23(31)28-20-15-19(24(25,26)27)8-9-21(20)30-13-11-29(12-14-30)16-18-5-3-2-4-6-18/h2-10,15H,11-14,16H2,1H3,(H,28,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 4.40n/an/an/an/an/a30



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9695160 (2017)


BindingDB Entry DOI: 10.7270/Q2639MW1
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101690
PNG
(US9695160, 21 | US9796707, Compound 21)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccccc3)CC2)c(NC(=O)c2ccc(o2)-c2cccnc2)c1
Show InChI InChI=1S/C28H25F3N4O2/c29-28(30,31)22-8-9-24(35-15-13-34(14-16-35)19-20-5-2-1-3-6-20)23(17-22)33-27(36)26-11-10-25(37-26)21-7-4-12-32-18-21/h1-12,17-18H,13-16,19H2,(H,33,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 4.60n/an/an/an/an/a30



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9695160 (2017)


BindingDB Entry DOI: 10.7270/Q2639MW1
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM101690
PNG
(US9695160, 21 | US9796707, Compound 21)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccccc3)CC2)c(NC(=O)c2ccc(o2)-c2cccnc2)c1
Show InChI InChI=1S/C28H25F3N4O2/c29-28(30,31)22-8-9-24(35-15-13-34(14-16-35)19-20-5-2-1-3-6-20)23(17-22)33-27(36)26-11-10-25(37-26)21-7-4-12-32-18-21/h1-12,17-18H,13-16,19H2,(H,33,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
US Patent
n/an/a 4.60n/an/an/an/an/an/a



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9796707 (2017)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2125VTM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM101824
PNG
(US9695160, 38 | US9796707, Compound 38)
Show SMILES OCc1cccc(c1)-c1ccc(o1)C(=O)Nc1cc(ccc1N1CCN(Cc2ccccn2)CC1)C(F)(F)F
Show InChI InChI=1S/C29H27F3N4O3/c30-29(31,32)22-7-8-25(36-14-12-35(13-15-36)18-23-6-1-2-11-33-23)24(17-22)34-28(38)27-10-9-26(39-27)21-5-3-4-20(16-21)19-37/h1-11,16-17,37H,12-15,18-19H2,(H,34,38)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
US Patent
n/an/a 5n/an/an/an/an/an/a



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9796707 (2017)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2125VTM
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101824
PNG
(US9695160, 38 | US9796707, Compound 38)
Show SMILES OCc1cccc(c1)-c1ccc(o1)C(=O)Nc1cc(ccc1N1CCN(Cc2ccccn2)CC1)C(F)(F)F
Show InChI InChI=1S/C29H27F3N4O3/c30-29(31,32)22-7-8-25(36-14-12-35(13-15-36)18-23-6-1-2-11-33-23)24(17-22)34-28(38)27-10-9-26(39-27)21-5-3-4-20(16-21)19-37/h1-11,16-17,37H,12-15,18-19H2,(H,34,38)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 5n/an/an/an/an/a30



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9695160 (2017)


BindingDB Entry DOI: 10.7270/Q2639MW1
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM221074
PNG
(SPHINX31 | US9695160, 12 | US9796707, Compound 12)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccccn3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C27H24F3N5O2/c28-27(29,30)20-4-5-23(35-15-13-34(14-16-35)18-21-3-1-2-10-32-21)22(17-20)33-26(36)25-7-6-24(37-25)19-8-11-31-12-9-19/h1-12,17H,13-16,18H2,(H,33,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
PDB
UniChem
PDB
Article
PubMed
n/an/a 5.90n/an/an/an/a7.530



Exonate Ltd



Assay Description
A reaction buffer containing 200 mM Tris pH 7.5, 100 mM MgCl2 and 0.1 mg/ml BSA was added to 43 μM SRSF1Arg-Ser (RS) peptide (NH2-RSPSYGRSRSRSRS...


ACS Chem Biol 12: 825-832 (2017)


Article DOI: 10.1021/acschembio.6b01048
BindingDB Entry DOI: 10.7270/Q2K64GXC
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM221074
PNG
(SPHINX31 | US9695160, 12 | US9796707, Compound 12)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccccn3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C27H24F3N5O2/c28-27(29,30)20-4-5-23(35-15-13-34(14-16-35)18-21-3-1-2-10-32-21)22(17-20)33-26(36)25-7-6-24(37-25)19-8-11-31-12-9-19/h1-12,17H,13-16,18H2,(H,33,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
PDB
UniChem
PDB
Article
PubMed
n/an/a 6n/an/an/an/a7.530



Exonate Ltd



Assay Description
A reaction buffer containing 200 mM Tris pH 7.5, 100 mM MgCl2 and 0.1 mg/ml BSA was added to 43 μM SRSF1Arg-Ser (RS) peptide (NH2-RSPSYGRSRSRSRS...


ACS Chem Biol 12: 825-832 (2017)


Article DOI: 10.1021/acschembio.6b01048
BindingDB Entry DOI: 10.7270/Q2K64GXC
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101654
PNG
(US9695160, 14 | US9796707, Compound 14)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccncc3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C27H24F3N5O2/c28-27(29,30)21-1-2-23(35-15-13-34(14-16-35)18-19-5-9-31-10-6-19)22(17-21)33-26(36)25-4-3-24(37-25)20-7-11-32-12-8-20/h1-12,17H,13-16,18H2,(H,33,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 7.18n/an/an/an/an/a30



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9695160 (2017)


BindingDB Entry DOI: 10.7270/Q2639MW1
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM101654
PNG
(US9695160, 14 | US9796707, Compound 14)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccncc3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C27H24F3N5O2/c28-27(29,30)21-1-2-23(35-15-13-34(14-16-35)18-19-5-9-31-10-6-19)22(17-21)33-26(36)25-4-3-24(37-25)20-7-11-32-12-8-20/h1-12,17H,13-16,18H2,(H,33,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
US Patent
n/an/a 7.18n/an/an/an/an/an/a



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9796707 (2017)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2125VTM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM101713
PNG
(US9695160, 25 | US9796707, Compound 25)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccccn3)CC2)c(NC(=O)c2ccc(o2)-c2cccnc2)c1
Show InChI InChI=1S/C27H24F3N5O2/c28-27(29,30)20-6-7-23(35-14-12-34(13-15-35)18-21-5-1-2-11-32-21)22(16-20)33-26(36)25-9-8-24(37-25)19-4-3-10-31-17-19/h1-11,16-17H,12-15,18H2,(H,33,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
US Patent
n/an/a 13.5n/an/an/an/an/an/a



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9796707 (2017)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2125VTM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM101671
PNG
(US9695160, 18 | US9796707, Compound 18)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccccn3)CC2)c(NC(=O)c2ccc(o2)-c2ccc3[nH]ccc3c2)c1
Show InChI InChI=1S/C30H26F3N5O2/c31-30(32,33)22-5-7-26(38-15-13-37(14-16-38)19-23-3-1-2-11-34-23)25(18-22)36-29(39)28-9-8-27(40-28)21-4-6-24-20(17-21)10-12-35-24/h1-12,17-18,35H,13-16,19H2,(H,36,39)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
US Patent
n/an/a 13.9n/an/an/an/an/an/a



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9796707 (2017)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2125VTM
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101674
PNG
(US9695160, 19 | US9796707, Compound 19)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccccc3)CC2)c(NC(=O)c2ccco2)c1
Show InChI InChI=1S/C23H22F3N3O2/c24-23(25,26)18-8-9-20(19(15-18)27-22(30)21-7-4-14-31-21)29-12-10-28(11-13-29)16-17-5-2-1-3-6-17/h1-9,14-15H,10-13,16H2,(H,27,30)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 14n/an/an/an/an/a30



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9695160 (2017)


BindingDB Entry DOI: 10.7270/Q2639MW1
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101671
PNG
(US9695160, 18 | US9796707, Compound 18)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccccn3)CC2)c(NC(=O)c2ccc(o2)-c2ccc3[nH]ccc3c2)c1
Show InChI InChI=1S/C30H26F3N5O2/c31-30(32,33)22-5-7-26(38-15-13-37(14-16-38)19-23-3-1-2-11-34-23)25(18-22)36-29(39)28-9-8-27(40-28)21-4-6-24-20(17-21)10-12-35-24/h1-12,17-18,35H,13-16,19H2,(H,36,39)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 14n/an/an/an/an/a30



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9695160 (2017)


BindingDB Entry DOI: 10.7270/Q2639MW1
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101713
PNG
(US9695160, 25 | US9796707, Compound 25)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccccn3)CC2)c(NC(=O)c2ccc(o2)-c2cccnc2)c1
Show InChI InChI=1S/C27H24F3N5O2/c28-27(29,30)20-6-7-23(35-14-12-34(13-15-35)18-21-5-1-2-11-32-21)22(16-20)33-26(36)25-9-8-24(37-25)19-4-3-10-31-17-19/h1-11,16-17H,12-15,18H2,(H,33,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 14n/an/an/an/an/a30



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9695160 (2017)


BindingDB Entry DOI: 10.7270/Q2639MW1
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM101674
PNG
(US9695160, 19 | US9796707, Compound 19)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccccc3)CC2)c(NC(=O)c2ccco2)c1
Show InChI InChI=1S/C23H22F3N3O2/c24-23(25,26)18-8-9-20(19(15-18)27-22(30)21-7-4-14-31-21)29-12-10-28(11-13-29)16-17-5-2-1-3-6-17/h1-9,14-15H,10-13,16H2,(H,27,30)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
US Patent
n/an/a 14.1n/an/an/an/an/an/a



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9796707 (2017)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2125VTM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM101695
PNG
(US9695160, 22 | US9796707, Compound 22)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccccc3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C28H25F3N4O2/c29-28(30,31)22-6-7-24(35-16-14-34(15-17-35)19-20-4-2-1-3-5-20)23(18-22)33-27(36)26-9-8-25(37-26)21-10-12-32-13-11-21/h1-13,18H,14-17,19H2,(H,33,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
US Patent
n/an/a 14.8n/an/an/an/an/an/a



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9796707 (2017)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2125VTM
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101695
PNG
(US9695160, 22 | US9796707, Compound 22)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccccc3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C28H25F3N4O2/c29-28(30,31)22-6-7-24(35-16-14-34(15-17-35)19-20-4-2-1-3-5-20)23(18-22)33-27(36)26-9-8-25(37-26)21-10-12-32-13-11-21/h1-13,18H,14-17,19H2,(H,33,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 15n/an/an/an/an/a30



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9695160 (2017)


BindingDB Entry DOI: 10.7270/Q2639MW1
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM101657
PNG
(US9695160, 15 | US9796707, Compound 15)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccccn3)CC2)c(NC(=O)c2ccco2)c1
Show InChI InChI=1S/C22H21F3N4O2/c23-22(24,25)16-6-7-19(18(14-16)27-21(30)20-5-3-13-31-20)29-11-9-28(10-12-29)15-17-4-1-2-8-26-17/h1-8,13-14H,9-12,15H2,(H,27,30)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
US Patent
n/an/a 16.6n/an/an/an/an/an/a



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9796707 (2017)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2125VTM
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101649
PNG
(US9695160, 13 | US9796707, Compound 13)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cccnc3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C27H24F3N5O2/c28-27(29,30)21-3-4-23(35-14-12-34(13-15-35)18-19-2-1-9-32-17-19)22(16-21)33-26(36)25-6-5-24(37-25)20-7-10-31-11-8-20/h1-11,16-17H,12-15,18H2,(H,33,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 17n/an/an/an/an/a30



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9695160 (2017)


BindingDB Entry DOI: 10.7270/Q2639MW1
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101657
PNG
(US9695160, 15 | US9796707, Compound 15)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccccn3)CC2)c(NC(=O)c2ccco2)c1
Show InChI InChI=1S/C22H21F3N4O2/c23-22(24,25)16-6-7-19(18(14-16)27-21(30)20-5-3-13-31-20)29-11-9-28(10-12-29)15-17-4-1-2-8-26-17/h1-8,13-14H,9-12,15H2,(H,27,30)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 17n/an/an/an/an/a30



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9695160 (2017)


BindingDB Entry DOI: 10.7270/Q2639MW1
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM101649
PNG
(US9695160, 13 | US9796707, Compound 13)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cccnc3)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C27H24F3N5O2/c28-27(29,30)21-3-4-23(35-14-12-34(13-15-35)18-19-2-1-9-32-17-19)22(16-21)33-26(36)25-6-5-24(37-25)20-7-10-31-11-8-20/h1-11,16-17H,12-15,18H2,(H,33,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
US Patent
n/an/a 17.2n/an/an/an/an/an/a



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9796707 (2017)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2125VTM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM221072
PNG
(SPHINX scaffold, 2)
Show SMILES CN1CCN(CC1)c1ccc(cc1NC(=O)c1ccc(o1)-c1ccncc1)C(F)(F)F
Show InChI InChI=1S/C22H21F3N4O2/c1-28-10-12-29(13-11-28)18-3-2-16(22(23,24)25)14-17(18)27-21(30)20-5-4-19(31-20)15-6-8-26-9-7-15/h2-9,14H,10-13H2,1H3,(H,27,30)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 20n/an/an/an/a7.530



Exonate Ltd



Assay Description
A reaction buffer containing 200 mM Tris pH 7.5, 100 mM MgCl2 and 0.1 mg/ml BSA was added to 43 μM SRSF1Arg-Ser (RS) peptide (NH2-RSPSYGRSRSRSRS...


ACS Chem Biol 12: 825-832 (2017)


Article DOI: 10.1021/acschembio.6b01048
BindingDB Entry DOI: 10.7270/Q2K64GXC
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM221071
PNG
(SPHINX scaffold, 1)
Show SMILES CN1CCN(CC1)c1ccc(cc1NC(=O)c1ccc(C)o1)C(F)(F)F
Show InChI InChI=1S/C18H20F3N3O2/c1-12-3-6-16(26-12)17(25)22-14-11-13(18(19,20)21)4-5-15(14)24-9-7-23(2)8-10-24/h3-6,11H,7-10H2,1-2H3,(H,22,25)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
PDB
UniChem
PDB
Article
PubMed
n/an/a 31n/an/an/an/a7.530



Exonate Ltd



Assay Description
A reaction buffer containing 200 mM Tris pH 7.5, 100 mM MgCl2 and 0.1 mg/ml BSA was added to 43 μM SRSF1Arg-Ser (RS) peptide (NH2-RSPSYGRSRSRSRS...


ACS Chem Biol 12: 825-832 (2017)


Article DOI: 10.1021/acschembio.6b01048
BindingDB Entry DOI: 10.7270/Q2K64GXC
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101659
PNG
(US9695160, 16 | US9796707, Compound 16)
Show SMILES Cc1ccc(o1)C(=O)Nc1cc(ccc1N1CCN(Cc2ccccn2)CC1)C(F)(F)F
Show InChI InChI=1S/C23H23F3N4O2/c1-16-5-8-21(32-16)22(31)28-19-14-17(23(24,25)26)6-7-20(19)30-12-10-29(11-13-30)15-18-4-2-3-9-27-18/h2-9,14H,10-13,15H2,1H3,(H,28,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 38n/an/an/an/an/a30



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9695160 (2017)


BindingDB Entry DOI: 10.7270/Q2639MW1
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM101659
PNG
(US9695160, 16 | US9796707, Compound 16)
Show SMILES Cc1ccc(o1)C(=O)Nc1cc(ccc1N1CCN(Cc2ccccn2)CC1)C(F)(F)F
Show InChI InChI=1S/C23H23F3N4O2/c1-16-5-8-21(32-16)22(31)28-19-14-17(23(24,25)26)6-7-20(19)30-12-10-29(11-13-30)15-18-4-2-3-9-27-18/h2-9,14H,10-13,15H2,1H3,(H,28,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
US Patent
n/an/a 38.2n/an/an/an/an/an/a



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9796707 (2017)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2125VTM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM50168247
PNG
(2,3-Di-thiophen-2-yl-benzo[g]quinoxaline-7-carboxy...)
Show SMILES OC(=O)c1ccc2cc3nc(-c4cccs4)c(nc3cc2c1)-c1cccs1
Show InChI InChI=1S/C21H12N2O2S2/c24-21(25)13-6-5-12-10-15-16(11-14(12)9-13)23-20(18-4-2-8-27-18)19(22-15)17-3-1-7-26-17/h1-11H,(H,24,25)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 40n/an/an/an/an/an/a



Covenant University

Curated by ChEMBL


Assay Description
Inhibition of SRPK1 kinase (unknown origin)


Eur J Med Chem 85: 688-715 (2014)


Article DOI: 10.1016/j.ejmech.2014.08.034
BindingDB Entry DOI: 10.7270/Q2JQ12P0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM221073
PNG
(SPHINX scaffold, 3 | US9695160, SPHINX7 | US979670...)
Show SMILES CN(C)CCN1CCN(CC1)c1ccc(cc1NC(=O)c1ccc(o1)-c1ccncc1)C(F)(F)F
Show InChI InChI=1S/C25H28F3N5O2/c1-31(2)11-12-32-13-15-33(16-14-32)21-4-3-19(25(26,27)28)17-20(21)30-24(34)23-6-5-22(35-23)18-7-9-29-10-8-18/h3-10,17H,11-16H2,1-2H3,(H,30,34)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 54.7n/an/an/an/an/an/a



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9796707 (2017)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2125VTM
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM221073
PNG
(SPHINX scaffold, 3 | US9695160, SPHINX7 | US979670...)
Show SMILES CN(C)CCN1CCN(CC1)c1ccc(cc1NC(=O)c1ccc(o1)-c1ccncc1)C(F)(F)F
Show InChI InChI=1S/C25H28F3N5O2/c1-31(2)11-12-32-13-15-33(16-14-32)21-4-3-19(25(26,27)28)17-20(21)30-24(34)23-6-5-22(35-23)18-7-9-29-10-8-18/h3-10,17H,11-16H2,1-2H3,(H,30,34)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 55n/an/an/an/an/a30



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9695160 (2017)


BindingDB Entry DOI: 10.7270/Q2639MW1
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM221073
PNG
(SPHINX scaffold, 3 | US9695160, SPHINX7 | US979670...)
Show SMILES CN(C)CCN1CCN(CC1)c1ccc(cc1NC(=O)c1ccc(o1)-c1ccncc1)C(F)(F)F
Show InChI InChI=1S/C25H28F3N5O2/c1-31(2)11-12-32-13-15-33(16-14-32)21-4-3-19(25(26,27)28)17-20(21)30-24(34)23-6-5-22(35-23)18-7-9-29-10-8-18/h3-10,17H,11-16H2,1-2H3,(H,30,34)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 59n/an/an/an/a7.530



Exonate Ltd



Assay Description
A reaction buffer containing 200 mM Tris pH 7.5, 100 mM MgCl2 and 0.1 mg/ml BSA was added to 43 μM SRSF1Arg-Ser (RS) peptide (NH2-RSPSYGRSRSRSRS...


ACS Chem Biol 12: 825-832 (2017)


Article DOI: 10.1021/acschembio.6b01048
BindingDB Entry DOI: 10.7270/Q2K64GXC
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101660
PNG
(US9695160, 17 | US9796707, Compound 17)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccccn3)CC2)c(NC(=O)c2ccc(o2)-c2ccccc2)c1
Show InChI InChI=1S/C28H25F3N4O2/c29-28(30,31)21-9-10-24(35-16-14-34(15-17-35)19-22-8-4-5-13-32-22)23(18-21)33-27(36)26-12-11-25(37-26)20-6-2-1-3-7-20/h1-13,18H,14-17,19H2,(H,33,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 111n/an/an/an/an/a30



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9695160 (2017)


BindingDB Entry DOI: 10.7270/Q2639MW1
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM101660
PNG
(US9695160, 17 | US9796707, Compound 17)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3ccccn3)CC2)c(NC(=O)c2ccc(o2)-c2ccccc2)c1
Show InChI InChI=1S/C28H25F3N4O2/c29-28(30,31)21-9-10-24(35-16-14-34(15-17-35)19-22-8-4-5-13-32-22)23(18-21)33-27(36)26-12-11-25(37-26)20-6-2-1-3-7-20/h1-13,18H,14-17,19H2,(H,33,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
US Patent
n/an/a 111n/an/an/an/an/an/a



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9796707 (2017)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2125VTM
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101832
PNG
(US9695160, 45 | US9796707, Compound 45)
Show SMILES OCc1ccc(o1)C(=O)Nc1cc(ccc1N1CCN(Cc2ccccn2)CC1)C(F)(F)F
Show InChI InChI=1S/C23H23F3N4O3/c24-23(25,26)16-4-6-20(19(13-16)28-22(32)21-7-5-18(15-31)33-21)30-11-9-29(10-12-30)14-17-3-1-2-8-27-17/h1-8,13,31H,9-12,14-15H2,(H,28,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 119n/an/an/an/an/a30



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9695160 (2017)


BindingDB Entry DOI: 10.7270/Q2639MW1
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM101832
PNG
(US9695160, 45 | US9796707, Compound 45)
Show SMILES OCc1ccc(o1)C(=O)Nc1cc(ccc1N1CCN(Cc2ccccn2)CC1)C(F)(F)F
Show InChI InChI=1S/C23H23F3N4O3/c24-23(25,26)16-4-6-20(19(13-16)28-22(32)21-7-5-18(15-31)33-21)30-11-9-29(10-12-30)14-17-3-1-2-8-27-17/h1-8,13,31H,9-12,14-15H2,(H,28,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 119n/an/an/an/an/an/a



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9796707 (2017)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2125VTM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM101829
PNG
(US9695160, 42 | US9796707, Compound 42)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3c[nH]c4ccccc34)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C30H26F3N5O2/c31-30(32,33)22-5-6-26(25(17-22)36-29(39)28-8-7-27(40-28)20-9-11-34-12-10-20)38-15-13-37(14-16-38)19-21-18-35-24-4-2-1-3-23(21)24/h1-12,17-18,35H,13-16,19H2,(H,36,39)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
US Patent
n/an/a 164n/an/an/an/an/an/a



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9796707 (2017)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2125VTM
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101829
PNG
(US9695160, 42 | US9796707, Compound 42)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3c[nH]c4ccccc34)CC2)c(NC(=O)c2ccc(o2)-c2ccncc2)c1
Show InChI InChI=1S/C30H26F3N5O2/c31-30(32,33)22-5-6-26(25(17-22)36-29(39)28-8-7-27(40-28)20-9-11-34-12-10-20)38-15-13-37(14-16-38)19-21-18-35-24-4-2-1-3-23(21)24/h1-12,17-18,35H,13-16,19H2,(H,36,39)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 164n/an/an/an/an/a30



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9695160 (2017)


BindingDB Entry DOI: 10.7270/Q2639MW1
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM101815
PNG
(US9695160, 36 | US9796707, Compound 36)
Show SMILES COc1cc(ccn1)-c1ccc(o1)C(=O)Nc1cc(ccc1N1CCN(Cc2ccccn2)CC1)C(F)(F)F
Show InChI InChI=1S/C28H26F3N5O3/c1-38-26-16-19(9-11-33-26)24-7-8-25(39-24)27(37)34-22-17-20(28(29,30)31)5-6-23(22)36-14-12-35(13-15-36)18-21-4-2-3-10-32-21/h2-11,16-17H,12-15,18H2,1H3,(H,34,37)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
US Patent
n/an/a 170n/an/an/an/an/an/a



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9796707 (2017)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2125VTM
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101815
PNG
(US9695160, 36 | US9796707, Compound 36)
Show SMILES COc1cc(ccn1)-c1ccc(o1)C(=O)Nc1cc(ccc1N1CCN(Cc2ccccn2)CC1)C(F)(F)F
Show InChI InChI=1S/C28H26F3N5O3/c1-38-26-16-19(9-11-33-26)24-7-8-25(39-24)27(37)34-22-17-20(28(29,30)31)5-6-23(22)36-14-12-35(13-15-36)18-21-4-2-3-10-32-21/h2-11,16-17H,12-15,18H2,1H3,(H,34,37)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 170n/an/an/an/an/a30



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9695160 (2017)


BindingDB Entry DOI: 10.7270/Q2639MW1
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101830
PNG
(US9695160, 43 | US9796707, Compound 43)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cnccn3)CC2)c(NC(=O)c2ccco2)c1
Show InChI InChI=1S/C21H20F3N5O2/c22-21(23,24)15-3-4-18(17(12-15)27-20(30)19-2-1-11-31-19)29-9-7-28(8-10-29)14-16-13-25-5-6-26-16/h1-6,11-13H,7-10,14H2,(H,27,30)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 183n/an/an/an/an/a30



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9695160 (2017)


BindingDB Entry DOI: 10.7270/Q2639MW1
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM101830
PNG
(US9695160, 43 | US9796707, Compound 43)
Show SMILES FC(F)(F)c1ccc(N2CCN(Cc3cnccn3)CC2)c(NC(=O)c2ccco2)c1
Show InChI InChI=1S/C21H20F3N5O2/c22-21(23,24)15-3-4-18(17(12-15)27-20(30)19-2-1-11-31-19)29-9-7-28(8-10-29)14-16-13-25-5-6-26-16/h1-6,11-13H,7-10,14H2,(H,27,30)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
US Patent
n/an/a 183n/an/an/an/an/an/a



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9796707 (2017)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2125VTM
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM101822
PNG
(US9695160, 37 | US9796707, Compound 37)
Show SMILES COc1ccc(cn1)-c1ccc(o1)C(=O)Nc1cc(ccc1N1CCN(Cc2ccccn2)CC1)C(F)(F)F
Show InChI InChI=1S/C28H26F3N5O3/c1-38-26-10-5-19(17-33-26)24-8-9-25(39-24)27(37)34-22-16-20(28(29,30)31)6-7-23(22)36-14-12-35(13-15-36)18-21-4-2-3-11-32-21/h2-11,16-17H,12-15,18H2,1H3,(H,34,37)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
US Patent
n/an/a 323n/an/an/an/an/an/a



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9796707 (2017)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2125VTM
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101822
PNG
(US9695160, 37 | US9796707, Compound 37)
Show SMILES COc1ccc(cn1)-c1ccc(o1)C(=O)Nc1cc(ccc1N1CCN(Cc2ccccn2)CC1)C(F)(F)F
Show InChI InChI=1S/C28H26F3N5O3/c1-38-26-10-5-19(17-33-26)24-8-9-25(39-24)27(37)34-22-16-20(28(29,30)31)6-7-23(22)36-14-12-35(13-15-36)18-21-4-2-3-11-32-21/h2-11,16-17H,12-15,18H2,1H3,(H,34,37)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 323n/an/an/an/an/a30



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9695160 (2017)


BindingDB Entry DOI: 10.7270/Q2639MW1
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase SRPK1


(Homo sapiens (Human))
BDBM101728
PNG
(US9695160, 30 | US9796707, Compound 30)
Show SMILES COc1ccc(CN2CCN(CC2)c2ccc(cc2NC(=O)c2ccc(o2)-c2ccncc2)C(F)(F)F)cc1
Show InChI InChI=1S/C29H27F3N4O3/c1-38-23-5-2-20(3-6-23)19-35-14-16-36(17-15-35)25-7-4-22(29(30,31)32)18-24(25)34-28(37)27-9-8-26(39-27)21-10-12-33-13-11-21/h2-13,18H,14-17,19H2,1H3,(H,34,37)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
US Patent
n/an/a 336n/an/an/an/an/an/a



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9796707 (2017)


Article DOI: 10.1016/j.bmcl.2006.05.056
BindingDB Entry DOI: 10.7270/Q2125VTM
More data for this
Ligand-Target Pair
SRSF protein kinase 1 (SRPK1)


(Homo sapiens (Human))
BDBM101728
PNG
(US9695160, 30 | US9796707, Compound 30)
Show SMILES COc1ccc(CN2CCN(CC2)c2ccc(cc2NC(=O)c2ccc(o2)-c2ccncc2)C(F)(F)F)cc1
Show InChI InChI=1S/C29H27F3N4O3/c1-38-23-5-2-20(3-6-23)19-35-14-16-36(17-15-35)25-7-4-22(29(30,31)32)18-24(25)34-28(37)27-9-8-26(39-27)21-10-12-33-13-11-21/h2-13,18H,14-17,19H2,1H3,(H,34,37)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 336n/an/an/an/an/a30



The University of Nottingham

US Patent


Assay Description
Candidate compounds were screened by the Kinase-Glo assay (Promega; Koresawa and Okabe, 2004), the results of which are shown in Table 1 and Table 2....


US Patent US9695160 (2017)


BindingDB Entry DOI: 10.7270/Q2639MW1
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 85 total )  |  Next  |  Last  >>
Jump to: