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Compile Data Set for Download or QSAR

Found 2216 hits of ic50 for UniProtKB: Q86V86   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM192574
PNG
(US9187486, 37 | US9187486, 39 | US9187486, 60)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1Nc1ncc2ccc(nn12)-c1c(F)cccc1F
Show InChI InChI=1S/C23H23F2N7/c1-14-9-15(26)13-31(12-14)21-7-8-27-11-20(21)29-23-28-10-16-5-6-19(30-32(16)23)22-17(24)3-2-4-18(22)25/h2-8,10-11,14-15H,9,12-13,26H2,1H3,(H,28,29)/t14-,15+/m1/s1
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n/an/a 0.0270n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of Pim3 (unknown origin)


Bioorg Med Chem Lett 26: 5580-5590 (2016)


Article DOI: 10.1016/j.bmcl.2016.09.067
BindingDB Entry DOI: 10.7270/Q261128M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 0.121n/an/an/an/an/an/a



West Virginia University

Curated by ChEMBL


Assay Description
Inhibition of human PIM3 using RSRHSSYPAGT as substrate in presence of [gamma-33P]-ATP


Bioorg Med Chem Lett 27: 2029-2037 (2017)


Article DOI: 10.1016/j.bmcl.2017.02.068
BindingDB Entry DOI: 10.7270/Q2474DB7
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM151870
PNG
(US8987457, 64)
Show SMILES C[C@H]1C[C@H](C[C@@H](N)[C@H]1OCCC#N)c1ccncc1NC(=O)c1nc(sc1N)-c1c(F)cccc1F
Show InChI InChI=1S/C25H26F2N6O2S/c1-13-10-14(11-18(29)22(13)35-9-3-7-28)15-6-8-31-12-19(15)32-24(34)21-23(30)36-25(33-21)20-16(26)4-2-5-17(20)27/h2,4-6,8,12-14,18,22H,3,9-11,29-30H2,1H3,(H,32,34)/t13-,14+,18+,22-/m0/s1
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n/an/a 0.220n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM151941
PNG
(US8987457, 135)
Show SMILES C[C@H]1C[C@H](C[C@@H](N)[C@H]1OCCS(C)(=O)=O)c1ccncc1NC(=O)c1nc(sc1N)-c1c(F)cccc1F
Show InChI InChI=1S/C25H29F2N5O4S2/c1-13-10-14(11-18(28)22(13)36-8-9-38(2,34)35)15-6-7-30-12-19(15)31-24(33)21-23(29)37-25(32-21)20-16(26)4-3-5-17(20)27/h3-7,12-14,18,22H,8-11,28-29H2,1-2H3,(H,31,33)/t13-,14+,18+,22-/m0/s1
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n/an/a 0.260n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM224899
PNG
(US9321756, 152)
Show SMILES N[C@H]1CCCCN1c1cccc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)s1
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n/an/a 0.307n/an/an/an/an/an/a



Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM151888
PNG
(US8987457, 82)
Show SMILES CO[C@H]1[C@@H](C)C[C@H](C[C@H]1N)c1ccncc1NC(=O)c1nc(sc1N)-c1c(F)cccc1F
Show InChI InChI=1S/C23H25F2N5O2S/c1-11-8-12(9-16(26)20(11)32-2)13-6-7-28-10-17(13)29-22(31)19-21(27)33-23(30-19)18-14(24)4-3-5-15(18)25/h3-7,10-12,16,20H,8-9,26-27H2,1-2H3,(H,29,31)/t11-,12+,16+,20-/m0/s1
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n/an/a 0.320n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM224980
PNG
(US9321756, 247)
Show SMILES C1CC1c1cncc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(NC2CNC2)o1
Show InChI InChI=1S/C20H19N7O/c1-2-11(1)17-9-22-10-18(25-17)15-8-23-16-4-3-12(5-14(15)16)19-26-27-20(28-19)24-13-6-21-7-13/h3-5,8-11,13,21,23H,1-2,6-7H2,(H,24,27)
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n/an/a 0.346n/an/an/an/an/an/a



Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM151972
PNG
(US8987457, 166)
Show SMILES C[C@H]1C[C@H](C[C@@H](N)[C@H]1OCCC#N)c1ccncc1NC(=O)c1nc(c(F)cc1N)-c1c(F)cccc1F
Show InChI InChI=1S/C27H27F3N6O2/c1-14-10-15(11-21(33)26(14)38-9-3-7-31)16-6-8-34-13-22(16)35-27(37)25-20(32)12-19(30)24(36-25)23-17(28)4-2-5-18(23)29/h2,4-6,8,12-15,21,26H,3,9-11,32-33H2,1H3,(H,35,37)/t14-,15+,21+,26-/m0/s1
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n/an/a 0.360n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM151952
PNG
(US8987457, 146)
Show SMILES C[C@H]1C[C@H](C[C@@H](N)[C@H]1OCCS(C)(=O)=O)c1ccncc1NC(=O)c1nc(c(F)cc1N)-c1c(F)cccc1F
Show InChI InChI=1S/C27H30F3N5O4S/c1-14-10-15(11-21(32)26(14)39-8-9-40(2,37)38)16-6-7-33-13-22(16)34-27(36)25-20(31)12-19(30)24(35-25)23-17(28)4-3-5-18(23)29/h3-7,12-15,21,26H,8-11,31-32H2,1-2H3,(H,34,36)/t14-,15+,21+,26-/m0/s1
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n/an/a 0.390n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM50061168
PNG
(CHEMBL3393706)
Show SMILES Fc1cccc(F)c1-c1ccc2[nH]nc(-c3cncc(O[C@H]4CNCCC44CC4)n3)c2c1
Show InChI InChI=1S/C24H21F2N5O/c25-16-2-1-3-17(26)22(16)14-4-5-18-15(10-14)23(31-30-18)19-11-28-13-21(29-19)32-20-12-27-9-8-24(20)6-7-24/h1-5,10-11,13,20,27H,6-9,12H2,(H,30,31)/t20-/m0/s1
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n/an/a 0.400n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant Pim-3 (unknown origin) assessed as phosphorylation of biotinylated-BAD peptide at Serine 112 residue


Bioorg Med Chem Lett 25: 834-40 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.068
BindingDB Entry DOI: 10.7270/Q2XP76KN
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM50232778
PNG
(CHEMBL4062256)
Show SMILES COc1ccc2C(=O)\C(Oc2c1CN1CCNCC1)=C\c1c[nH]c2nc(Cl)ccc12
Show InChI InChI=1S/C22H21ClN4O3/c1-29-17-4-2-15-20(28)18(10-13-11-25-22-14(13)3-5-19(23)26-22)30-21(15)16(17)12-27-8-6-24-7-9-27/h2-5,10-11,24H,6-9,12H2,1H3,(H,25,26)/b18-10-
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n/an/a 0.400n/an/an/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human N-terminal GST-tagged PIM3 (1 to 326 end residues) expressed in baculovirus infected sf21 cells using S6K...


ACS Med Chem Lett 8: 504-509 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00518
BindingDB Entry DOI: 10.7270/Q2N58PK5
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM151875
PNG
(US8987457, 69)
Show SMILES CO[C@@H]1[C@@H](C)C[C@H](C[C@H]1N)c1ccncc1NC(=O)c1nc(sc1N)-c1c(F)cccc1F
Show InChI InChI=1S/C23H25F2N5O2S/c1-11-8-12(9-16(26)20(11)32-2)13-6-7-28-10-17(13)29-22(31)19-21(27)33-23(30-19)18-14(24)4-3-5-15(18)25/h3-7,10-12,16,20H,8-9,26-27H2,1-2H3,(H,29,31)/t11-,12+,16+,20+/m0/s1
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n/an/a 0.400n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM151980
PNG
(US8987457, 174)
Show SMILES COC(=O)N[C@H]1[C@@H](C)CN(C[C@H]1N)c1ccncc1NC(=O)c1nc(c(F)cc1N)-c1c(F)cccc1F
Show InChI InChI=1S/C25H26F3N7O3/c1-12-10-35(11-17(30)21(12)34-25(37)38-2)19-6-7-31-9-18(19)32-24(36)23-16(29)8-15(28)22(33-23)20-13(26)4-3-5-14(20)27/h3-9,12,17,21H,10-11,29-30H2,1-2H3,(H,32,36)(H,34,37)/t12-,17+,21-/m0/s1
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n/an/a 0.410n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM224903
PNG
(US9321756, 155)
Show SMILES Cc1cn(cn1)-c1cccc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)s1
Show InChI InChI=1S/C19H15N7S/c1-11-9-26(10-22-11)17-4-2-3-16(23-17)14-8-21-15-6-5-12(7-13(14)15)18-24-25-19(20)27-18/h2-10,21H,1H3,(H2,20,25)
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n/an/a 0.425n/an/an/an/an/an/a



Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM151878
PNG
(US8987457, 72)
Show SMILES COC(=O)N[C@H]1[C@@H](C)CN(C[C@H]1N)c1ccncc1NC(=O)c1nc(sc1N)-c1c(F)cccc1F
Show InChI InChI=1S/C23H25F2N7O3S/c1-11-9-32(10-14(26)18(11)31-23(34)35-2)16-6-7-28-8-15(16)29-21(33)19-20(27)36-22(30-19)17-12(24)4-3-5-13(17)25/h3-8,11,14,18H,9-10,26-27H2,1-2H3,(H,29,33)(H,31,34)/t11-,14+,18-/m0/s1
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n/an/a 0.430n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM224998
PNG
(US9321756, 264 | US9321756, 265)
Show SMILES CC(C)Nc1nnc(o1)-c1ccc2[nH]cc(-c3nccc(n3)C3CC3)c2c1
Show InChI InChI=1S/C20H20N6O/c1-11(2)23-20-26-25-19(27-20)13-5-6-17-14(9-13)15(10-22-17)18-21-8-7-16(24-18)12-3-4-12/h5-12,22H,3-4H2,1-2H3,(H,23,26)
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n/an/a 0.435n/an/an/an/an/an/a



Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM151867
PNG
(US8987457, 61)
Show SMILES COC(=O)N(C)[C@H]1[C@@H](C)CN(C[C@H]1N)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F
Show InChI InChI=1S/C26H27F3N6O3/c1-14-12-35(13-18(30)24(14)34(2)26(37)38-3)21-9-10-31-11-20(21)33-25(36)19-8-7-17(29)23(32-19)22-15(27)5-4-6-16(22)28/h4-11,14,18,24H,12-13,30H2,1-3H3,(H,33,36)/t14-,18+,24-/m0/s1
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n/an/a 0.490n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM151864
PNG
(US8987457, 58)
Show SMILES COC(=O)N(C)[C@H]1[C@@H](C)CN(C[C@H]1N)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cc(C)cc1F
Show InChI InChI=1S/C27H29F3N6O3/c1-14-9-17(29)23(18(30)10-14)24-16(28)5-6-20(33-24)26(37)34-21-11-32-8-7-22(21)36-12-15(2)25(19(31)13-36)35(3)27(38)39-4/h5-11,15,19,25H,12-13,31H2,1-4H3,(H,34,37)/t15-,19+,25-/m0/s1
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n/an/a 0.490n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM225077
PNG
(US9321756, 46)
Show SMILES CC(C)Nc1nnc(o1)-c1ccc2[nH]cc(-c3cncc(n3)C3CC3)c2c1
Show InChI InChI=1S/C20H20N6O/c1-11(2)23-20-26-25-19(27-20)13-5-6-16-14(7-13)15(8-22-16)18-10-21-9-17(24-18)12-3-4-12/h5-12,22H,3-4H2,1-2H3,(H,23,26)
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n/an/a 0.498n/an/an/an/an/an/a



Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM151877
PNG
(US8987457, 71)
Show SMILES CCO[C@H]1[C@@H](C)C[C@H](C[C@H]1N)c1ccncc1NC(=O)c1nc(sc1N)-c1c(F)cccc1F
Show InChI InChI=1S/C24H27F2N5O2S/c1-3-33-21-12(2)9-13(10-17(21)27)14-7-8-29-11-18(14)30-23(32)20-22(28)34-24(31-20)19-15(25)5-4-6-16(19)26/h4-8,11-13,17,21H,3,9-10,27-28H2,1-2H3,(H,30,32)/t12-,13+,17+,21-/m0/s1
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n/an/a 0.540n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM151954
PNG
(US8987457, 148)
Show SMILES COC(=O)N[C@H]1[C@@H](C)CN(C[C@H]1N)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cc(OC(C)C)cc1F
Show InChI InChI=1S/C28H31F3N6O4/c1-14(2)41-16-9-18(30)24(19(31)10-16)26-17(29)5-6-21(34-26)27(38)35-22-11-33-8-7-23(22)37-12-15(3)25(20(32)13-37)36-28(39)40-4/h5-11,14-15,20,25H,12-13,32H2,1-4H3,(H,35,38)(H,36,39)/t15-,20+,25-/m0/s1
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n/an/a 0.550n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM139540
PNG
(US10189849, staurosporine | US10307427, Staurospor...)
Show SMILES CN[C@@H]1CC2OC([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C27H24N4O3/c1-28-16-11-19-30-17-9-5-4-8-14(17)21-22-15(12-29-26(22)32)20-13-7-3-6-10-18(13)31(23(20)24(21)30)27(34-19)25(16)33-2/h3-10,16,19,25,27-28H,11-12H2,1-2H3,(H,29,32)/t16-,19?,25-,27?/m1/s1
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n/an/a 0.570n/an/an/an/an/an/a



Temple University

US Patent


Assay Description
The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...


US Patent US8889696 (2014)


BindingDB Entry DOI: 10.7270/Q2930RVR
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM225042
PNG
(US9321756, 4)
Show SMILES Nc1nnc(o1)-c1ccc2[nH]cc(-c3cncc(NC4CCCC4)n3)c2c1
Show InChI InChI=1S/C19H19N7O/c20-19-26-25-18(27-19)11-5-6-15-13(7-11)14(8-22-15)16-9-21-10-17(24-16)23-12-3-1-2-4-12/h5-10,12,22H,1-4H2,(H2,20,26)(H,23,24)
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n/an/a 0.586n/an/an/an/an/an/a



Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM151839
PNG
(US8987457, 33)
Show SMILES CS[C@H]1[C@@H](C)C[C@H](C[C@H]1N)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F
Show InChI InChI=1S/C25H25F3N4OS/c1-13-10-14(11-19(29)24(13)34-2)15-8-9-30-12-21(15)32-25(33)20-7-6-18(28)23(31-20)22-16(26)4-3-5-17(22)27/h3-9,12-14,19,24H,10-11,29H2,1-2H3,(H,32,33)/t13-,14+,19+,24-/m0/s1
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n/an/a 0.610n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM151999
PNG
(US8987457, 193)
Show SMILES COc1cc(F)c(c(F)c1)-c1nc(ccc1F)C(=O)Nc1cnccc1N1C[C@H](C)[C@@H]([C@H](N)C1)n1ccnn1
Show InChI InChI=1S/C26H25F3N8O2/c1-14-12-36(13-19(30)25(14)37-8-7-32-35-37)22-5-6-31-11-21(22)34-26(38)20-4-3-16(27)24(33-20)23-17(28)9-15(39-2)10-18(23)29/h3-11,14,19,25H,12-13,30H2,1-2H3,(H,34,38)/t14-,19+,25-/m0/s1
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n/an/a 0.620n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM151862
PNG
(US8987457, 56)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@H]1n1cncn1)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F
Show InChI InChI=1S/C25H23F3N8O/c1-14-10-35(11-18(29)24(14)36-13-31-12-32-36)21-7-8-30-9-20(21)34-25(37)19-6-5-17(28)23(33-19)22-15(26)3-2-4-16(22)27/h2-9,12-14,18,24H,10-11,29H2,1H3,(H,34,37)/t14-,18+,24-/m0/s1
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n/an/a 0.620n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM225051
PNG
(US9321756, 13)
Show SMILES CN1CCN(CC1)c1cccc(n1)-c1c[nH]c2ccc(cc12)-c1nnc(N)s1
Show InChI InChI=1S/C20H21N7S/c1-26-7-9-27(10-8-26)18-4-2-3-17(23-18)15-12-22-16-6-5-13(11-14(15)16)19-24-25-20(21)28-19/h2-6,11-12,22H,7-10H2,1H3,(H2,21,25)
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n/an/a 0.625n/an/an/an/an/an/a



Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM151889
PNG
(US8987457, 83)
Show SMILES C[C@H]1C[C@H](C[C@@H](N)[C@H]1OCCC#N)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cc(C)cc1F
Show InChI InChI=1S/C28H28F3N5O2/c1-15-10-20(30)25(21(31)11-15)26-19(29)4-5-23(35-26)28(37)36-24-14-34-8-6-18(24)17-12-16(2)27(22(33)13-17)38-9-3-7-32/h4-6,8,10-11,14,16-17,22,27H,3,9,12-13,33H2,1-2H3,(H,36,37)/t16-,17+,22+,27-/m0/s1
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n/an/a 0.640n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM151811
PNG
(US8987457, 5)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@H]1n1ccnn1)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F
Show InChI InChI=1S/C25H23F3N8O/c1-14-12-35(13-18(29)24(14)36-10-9-31-34-36)21-7-8-30-11-20(21)33-25(37)19-6-5-17(28)23(32-19)22-15(26)3-2-4-16(22)27/h2-11,14,18,24H,12-13,29H2,1H3,(H,33,37)/t14-,18+,24-/m0/s1
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n/an/a 0.640n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM224841
PNG
(US9321756, 100)
Show SMILES Nc1nnc(o1)-c1ccc2[nH]cc(-c3cncc(NCC4CC4)n3)c2c1
Show InChI InChI=1S/C18H17N7O/c19-18-25-24-17(26-18)11-3-4-14-12(5-11)13(7-21-14)15-8-20-9-16(23-15)22-6-10-1-2-10/h3-5,7-10,21H,1-2,6H2,(H2,19,25)(H,22,23)
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n/an/a 0.668n/an/an/an/an/an/a



Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM151893
PNG
(US8987457, 87)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@H]1N=[N+]=[N-])c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F
Show InChI InChI=1S/C23H21F3N8O/c1-12-10-34(11-16(27)21(12)32-33-28)19-7-8-29-9-18(19)31-23(35)17-6-5-15(26)22(30-17)20-13(24)3-2-4-14(20)25/h2-9,12,16,21H,10-11,27H2,1H3,(H,31,35)/t12-,16+,21-/m0/s1
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n/an/a 0.680n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM50061178
PNG
(CHEMBL3393704)
Show SMILES Fc1cccc(F)c1-c1ccc2[nH]nc(-c3cncc(OC4CNCCC44CC4)n3)c2c1
Show InChI InChI=1S/C24H21F2N5O/c25-16-2-1-3-17(26)22(16)14-4-5-18-15(10-14)23(31-30-18)19-11-28-13-21(29-19)32-20-12-27-9-8-24(20)6-7-24/h1-5,10-11,13,20,27H,6-9,12H2,(H,30,31)
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n/an/a 0.700n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant Pim-3 (unknown origin) assessed as phosphorylation of biotinylated-BAD peptide at Serine 112 residue


Bioorg Med Chem Lett 25: 834-40 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.068
BindingDB Entry DOI: 10.7270/Q2XP76KN
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM50061199
PNG
(CHEMBL3393697)
Show SMILES Fc1cccc(F)c1-c1ccc2[nH]nc(-c3cncc(NC4CCNCC4)n3)c2c1
Show InChI InChI=1S/C22H20F2N6/c23-16-2-1-3-17(24)21(16)13-4-5-18-15(10-13)22(30-29-18)19-11-26-12-20(28-19)27-14-6-8-25-9-7-14/h1-5,10-12,14,25H,6-9H2,(H,27,28)(H,29,30)
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n/an/a 0.700n/an/an/an/an/an/a



Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant Pim-3 (unknown origin) assessed as phosphorylation of biotinylated-BAD peptide at Serine 112 residue


Bioorg Med Chem Lett 25: 834-40 (2015)


Article DOI: 10.1016/j.bmcl.2014.12.068
BindingDB Entry DOI: 10.7270/Q2XP76KN
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM151872
PNG
(US8987457, 66)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@H]1n1cc(CO)nn1)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F
Show InChI InChI=1S/C26H25F3N8O2/c1-14-10-36(12-19(30)25(14)37-11-15(13-38)34-35-37)22-7-8-31-9-21(22)33-26(39)20-6-5-18(29)24(32-20)23-16(27)3-2-4-17(23)28/h2-9,11,14,19,25,38H,10,12-13,30H2,1H3,(H,33,39)/t14-,19+,25-/m0/s1
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n/an/a 0.730n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM224873
PNG
(US9321756, 128)
Show SMILES CNc1nnc(s1)-c1ccc2[nH]cc(-c3nccc(n3)N3CCC[C@H](N)C3)c2c1
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n/an/a 0.734n/an/an/an/an/an/a



Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM151960
PNG
(US8987457, 154)
Show SMILES C[C@H]1C[C@H](C[C@@H](N)[C@H]1n1ccnn1)c1ccncc1NC(=O)c1nc(sc1N)-c1c(F)cccc1F
Show InChI InChI=1S/C24H24F2N8OS/c1-12-9-13(10-17(27)21(12)34-8-7-30-33-34)14-5-6-29-11-18(14)31-23(35)20-22(28)36-24(32-20)19-15(25)3-2-4-16(19)26/h2-8,11-13,17,21H,9-10,27-28H2,1H3,(H,31,35)/t12-,13+,17+,21-/m0/s1
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n/an/a 0.740n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM151887
PNG
(US8987457, 81)
Show SMILES COC(=O)N[C@H]1[C@@H](C)CN(C[C@H]1N)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F
Show InChI InChI=1S/C25H25F3N6O3/c1-13-11-34(12-17(29)22(13)33-25(36)37-2)20-8-9-30-10-19(20)32-24(35)18-7-6-16(28)23(31-18)21-14(26)4-3-5-15(21)27/h3-10,13,17,22H,11-12,29H2,1-2H3,(H,32,35)(H,33,36)/t13-,17+,22-/m0/s1
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n/an/a 0.740n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM151989
PNG
(US8987457, 183)
Show SMILES C[C@H]1C[C@H](C[C@@H](N)[C@H]1OCCC#N)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cc(OC2CCOCC2)cc1F
Show InChI InChI=1S/C32H34F3N5O4/c1-18-13-19(14-26(37)31(18)43-10-2-8-36)22-5-9-38-17-28(22)40-32(41)27-4-3-23(33)30(39-27)29-24(34)15-21(16-25(29)35)44-20-6-11-42-12-7-20/h3-5,9,15-20,26,31H,2,6-7,10-14,37H2,1H3,(H,40,41)/t18-,19+,26+,31-/m0/s1
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n/an/a 0.75n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM151965
PNG
(US8987457, 159)
Show SMILES COC(=O)N[C@H]1[C@@H](C)CN(C[C@H]1N)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cc(OC2CCOCC2)cc1F
Show InChI InChI=1S/C30H33F3N6O5/c1-16-14-39(15-22(34)27(16)38-30(41)42-2)25-5-8-35-13-24(25)37-29(40)23-4-3-19(31)28(36-23)26-20(32)11-18(12-21(26)33)44-17-6-9-43-10-7-17/h3-5,8,11-13,16-17,22,27H,6-7,9-10,14-15,34H2,1-2H3,(H,37,40)(H,38,41)/t16-,22+,27-/m0/s1
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n/an/a 0.75n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM151967
PNG
(US8987457, 161)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@H]1n1ccnn1)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cc(C)cc1F
Show InChI InChI=1S/C26H25F3N8O/c1-14-9-17(28)23(18(29)10-14)24-16(27)3-4-20(33-24)26(38)34-21-11-31-6-5-22(21)36-12-15(2)25(19(30)13-36)37-8-7-32-35-37/h3-11,15,19,25H,12-13,30H2,1-2H3,(H,34,38)/t15-,19+,25-/m0/s1
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n/an/a 0.760n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM50061613
PNG
(CHEMBL3394164 | US9321756, 17)
Show SMILES Nc1nnc(s1)-c1ccc2[nH]cc(-c3cncc(NC4CCCC4)n3)c2c1
Show InChI InChI=1S/C19H19N7S/c20-19-26-25-18(27-19)11-5-6-15-13(7-11)14(8-22-15)16-9-21-10-17(24-16)23-12-3-1-2-4-12/h5-10,12,22H,1-4H2,(H2,20,26)(H,23,24)
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n/an/a 0.763n/an/an/an/an/an/a



Amgen Inc

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM151886
PNG
(US8987457, 80)
Show SMILES COC(=O)N[C@H]1[C@@H](C)CN(C[C@H]1N)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cc(C)cc1F
Show InChI InChI=1S/C26H27F3N6O3/c1-13-8-16(28)22(17(29)9-13)24-15(27)4-5-19(32-24)25(36)33-20-10-31-7-6-21(20)35-11-14(2)23(18(30)12-35)34-26(37)38-3/h4-10,14,18,23H,11-12,30H2,1-3H3,(H,33,36)(H,34,37)/t14-,18+,23-/m0/s1
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n/an/a 0.790n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM151962
PNG
(US8987457, 156)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@H]1n1ccnn1)c1ccncc1NC(=O)c1nc(sc1N)-c1c(F)cccc1F
Show InChI InChI=1S/C23H23F2N9OS/c1-12-10-33(11-15(26)20(12)34-8-7-29-32-34)17-5-6-28-9-16(17)30-22(35)19-21(27)36-23(31-19)18-13(24)3-2-4-14(18)25/h2-9,12,15,20H,10-11,26-27H2,1H3,(H,30,35)/t12-,15+,20-/m0/s1
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n/an/a 0.800n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM50499276
PNG
(CHEMBL3735861)
Show SMILES COc1ccc2C(=O)\C(Oc2c1CN1CCN[C@@H](C)C1)=C\c1n[nH]c2ncccc12
Show InChI InChI=1S/C22H23N5O3/c1-13-11-27(9-8-23-13)12-16-18(29-2)6-5-15-20(28)19(30-21(15)16)10-17-14-4-3-7-24-22(14)26-25-17/h3-7,10,13,23H,8-9,11-12H2,1-2H3,(H,24,25,26)/b19-10-/t13-/m0/s1
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n/an/a 0.800n/an/an/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Inhibition of PIM3 (unknown origin) using FL-Peptide 1 (5-FAM-AKRRRLSSLRA-COOH) substrate incubated for 2 hrs by electrophoretic mobility shift assay


Bioorg Med Chem Lett 25: 5687-93 (2015)


Article DOI: 10.1016/j.bmcl.2015.10.098
BindingDB Entry DOI: 10.7270/Q2JD50SX
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM50364777
PNG
(CHEMBL1952142)
Show SMILES COc1cc(NCC2CCNCC2)nc2n(nnc12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C19H21F3N6O2/c1-29-15-10-16(24-11-12-5-7-23-8-6-12)25-18-17(15)26-27-28(18)13-3-2-4-14(9-13)30-19(20,21)22/h2-4,9-10,12,23H,5-8,11H2,1H3,(H,24,25)
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n/an/a 0.800n/an/an/an/an/an/a



Spanish National Cancer Research Centre (CNIO)

Curated by ChEMBL


Assay Description
Inhibition of N-terminal 6-His tagged human recombinant PIM3 using PIM tide (ARKRRRHPSGPPTA) as substrate incubated for 1 hr by fluorescence based as...


Eur J Med Chem 168: 87-109 (2019)


Article DOI: 10.1016/j.ejmech.2019.02.022
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM50364777
PNG
(CHEMBL1952142)
Show SMILES COc1cc(NCC2CCNCC2)nc2n(nnc12)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C19H21F3N6O2/c1-29-15-10-16(24-11-12-5-7-23-8-6-12)25-18-17(15)26-27-28(18)13-3-2-4-14(9-13)30-19(20,21)22/h2-4,9-10,12,23H,5-8,11H2,1H3,(H,24,25)
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n/an/a 0.800n/an/an/an/an/an/a



Spanish National Cancer Research Centre (CNIO)

Curated by ChEMBL


Assay Description
Inhibition of PIM3


Bioorg Med Chem Lett 22: 1591-7 (2012)


Article DOI: 10.1016/j.bmcl.2011.12.130
BindingDB Entry DOI: 10.7270/Q21R6QZ1
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM151982
PNG
(US8987457, 176)
Show SMILES C[C@H]1C[C@H](C[C@@H](N)[C@H]1n1ccnn1)c1ccncc1NC(=O)c1nc(c(F)cc1N)-c1c(F)cccc1F
Show InChI InChI=1S/C26H25F3N8O/c1-13-9-14(10-20(31)25(13)37-8-7-33-36-37)15-5-6-32-12-21(15)34-26(38)24-19(30)11-18(29)23(35-24)22-16(27)3-2-4-17(22)28/h2-8,11-14,20,25H,9-10,30-31H2,1H3,(H,34,38)/t13-,14+,20+,25-/m0/s1
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n/an/a 0.840n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM151813
PNG
(US8987457, 7)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@H]1n1cc(C)nn1)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cccc1F
Show InChI InChI=1S/C26H25F3N8O/c1-14-11-36(13-19(30)25(14)37-12-15(2)34-35-37)22-8-9-31-10-21(22)33-26(38)20-7-6-18(29)24(32-20)23-16(27)4-3-5-17(23)28/h3-10,12,14,19,25H,11,13,30H2,1-2H3,(H,33,38)/t14-,19+,25-/m0/s1
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n/an/a 0.860n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM151948
PNG
(US8987457, 142)
Show SMILES CO[C@@H]1[C@@H](C)C[C@H](C[C@H]1N)c1ccncc1NC(=O)c1ccc(F)c(n1)-c1c(F)cc(OC(C)C)cc1F
Show InChI InChI=1S/C28H31F3N4O3/c1-14(2)38-17-11-20(30)25(21(31)12-17)26-19(29)5-6-23(34-26)28(36)35-24-13-33-8-7-18(24)16-9-15(3)27(37-4)22(32)10-16/h5-8,11-16,22,27H,9-10,32H2,1-4H3,(H,35,36)/t15-,16+,22+,27+/m0/s1
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n/an/a 0.870n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
Pim 1, Pim 2 & Pim 3 AlphaScreen assays using high ATP (11-125.times. ATP Km) were used to determine the biochemical activity of the inhibitors. The ...


US Patent US8987457 (2015)


BindingDB Entry DOI: 10.7270/Q2765D2M
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM50232780
PNG
(CHEMBL4061176)
Show SMILES Oc1ccc2C(=O)\C(Oc2c1CN1CCNCC1)=C\c1c[nH]c2nc(Cl)ccc12
Show InChI InChI=1S/C21H19ClN4O3/c22-18-4-2-13-12(10-24-21(13)25-18)9-17-19(28)14-1-3-16(27)15(20(14)29-17)11-26-7-5-23-6-8-26/h1-4,9-10,23,27H,5-8,11H2,(H,24,25)/b17-9-
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n/an/a 0.880n/an/an/an/an/an/a



The University of Tokyo

Curated by ChEMBL


Assay Description
Inhibition of full length recombinant human N-terminal GST-tagged PIM3 (1 to 326 end residues) expressed in baculovirus infected sf21 cells using S6K...


ACS Med Chem Lett 8: 504-509 (2017)


Article DOI: 10.1021/acsmedchemlett.6b00518
BindingDB Entry DOI: 10.7270/Q2N58PK5
More data for this
Ligand-Target Pair
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