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Compile Data Set for Download or QSAR

Found 699 hits of ic50 data for polymerid = 5588   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50026981
PNG
(CHEMBL2370939)
Show SMILES CCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@](C)(CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(C)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]1CCC(=O)NNC(=O)C[C@H](NC(=O)[C@H](C)NC(=O)[C@@H](C)NC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@](C)(CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O
Show InChI InChI=1S/C186H312N52O55/c1-27-31-47-107(206-153(264)108(48-35-39-70-187)207-157(268)112(52-43-74-200-183(195)196)211-171(282)126(80-96(13)14)231-181(292)185(25,87-97(15)16)235-177(288)128(82-106-89-199-91-202-106)227-172(283)127(81-105-45-33-32-34-46-105)226-176(287)133(90-239)230-170(281)125(79-95(11)12)225-175(286)131(85-144(256)257)205-104(24)240)165(276)232-147(100(20)29-3)180(291)220-121(61-69-143(254)255)166(277)233-148(101(21)30-4)179(290)219-120(60-68-142(252)253)164(275)210-109(49-36-40-71-188)154(265)213-114(54-62-134(191)241)160(271)218-118(58-66-140(248)249)162(273)209-110(50-37-41-72-189)155(266)216-117(57-65-139(246)247)161(272)208-111(51-38-42-73-190)156(267)217-119(59-67-141(250)251)163(274)214-115(55-63-135(192)242)159(270)215-116-56-64-137(244)237-238-138(245)84-130(221-151(262)103(23)203-150(261)102(22)204-152(116)263)174(285)228-129(83-136(193)243)173(284)212-113(53-44-75-201-184(197)198)158(269)222-122(76-92(5)6)167(278)223-123(77-93(7)8)168(279)224-124(78-94(9)10)169(280)229-132(86-145(258)259)178(289)236-186(26,88-98(17)18)182(293)234-146(149(194)260)99(19)28-2/h32-34,45-46,89,91-103,107-133,146-148,239H,27-31,35-44,47-88,90,187-190H2,1-26H3,(H2,191,241)(H2,192,242)(H2,193,243)(H2,194,260)(H,199,202)(H,203,261)(H,204,263)(H,205,240)(H,206,264)(H,207,268)(H,208,272)(H,209,273)(H,210,275)(H,211,282)(H,212,284)(H,213,265)(H,214,274)(H,215,270)(H,216,266)(H,217,267)(H,218,271)(H,219,290)(H,220,291)(H,221,262)(H,222,269)(H,223,278)(H,224,279)(H,225,286)(H,226,287)(H,227,283)(H,228,285)(H,229,280)(H,230,281)(H,231,292)(H,232,276)(H,233,277)(H,234,293)(H,235,288)(H,236,289)(H,237,244)(H,238,245)(H,246,247)(H,248,249)(H,250,251)(H,252,253)(H,254,255)(H,256,257)(H,258,259)(H4,195,196,200)(H4,197,198,201)/t99-,100-,101-,102+,103-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116+,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,146-,147-,148-,185-,186-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.240n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of recombinant corticotropin releasing factor receptor 1 assayed using nonselective [125I]-labeled agonist [Tyr0,Glu1,Nle17]-sauvagine


J Med Chem 45: 4737-47 (2002)


Article DOI: 10.1021/jm0202122
BindingDB Entry DOI: 10.7270/Q2WQ04JR
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50370170
PNG
(CHEMBL1794009)
Show SMILES CCCC[C@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](N)Cc1ccccc1)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](NC(=O)[C@@H](Cc2c[nH]cn2)NC(=O)[C@H](C)NC1=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@H](C)CC)C(=O)N[C@@H]([C@H](C)CC)C(N)=O
Show InChI InChI=1S/C161H269N49O42/c1-23-27-41-96(189-145(239)107(52-59-123(217)218)199-152(246)114(71-84(13)14)207-157(251)126(85(15)16)208-147(241)108(53-60-124(219)220)197-140(234)102(47-38-66-179-161(172)173)193-151(245)112(69-82(9)10)204-153(247)113(70-83(11)12)205-155(249)116(74-94-77-175-79-181-94)201-134(228)95(163)72-92-39-30-29-31-40-92)135(229)182-88(19)130(224)186-100(45-36-64-177-159(168)169)136(230)183-89(20)131(225)188-106(51-58-122(215)216)144(238)195-104(49-56-119(165)212)146(240)202-110(67-80(5)6)149(243)185-90(21)132(226)187-103(48-55-118(164)211)143(237)196-105-50-57-121(214)176-63-35-33-44-99(192-154(248)115(73-93-76-174-78-180-93)200-133(227)91(22)184-137(105)231)142(236)206-117(75-120(166)213)156(250)194-101(46-37-65-178-160(170)171)139(233)190-98(43-32-34-62-162)141(235)203-111(68-81(7)8)150(244)191-97(42-28-24-2)138(232)198-109(54-61-125(221)222)148(242)210-128(87(18)26-4)158(252)209-127(129(167)223)86(17)25-3/h29-31,39-40,76-91,95-117,126-128H,23-28,32-38,41-75,162-163H2,1-22H3,(H2,164,211)(H2,165,212)(H2,166,213)(H2,167,223)(H,174,180)(H,175,181)(H,176,214)(H,182,229)(H,183,230)(H,184,231)(H,185,243)(H,186,224)(H,187,226)(H,188,225)(H,189,239)(H,190,233)(H,191,244)(H,192,248)(H,193,245)(H,194,250)(H,195,238)(H,196,237)(H,197,234)(H,198,232)(H,199,246)(H,200,227)(H,201,228)(H,202,240)(H,203,235)(H,204,247)(H,205,249)(H,206,236)(H,207,251)(H,208,241)(H,209,252)(H,210,242)(H,215,216)(H,217,218)(H,219,220)(H,221,222)(H4,168,169,177)(H4,170,171,178)(H4,172,173,179)/t86-,87-,88+,89+,90+,91+,95+,96+,97+,98+,99-,100+,101+,102+,103+,104+,105+,106+,107+,108+,109+,110+,111+,112+,113+,114+,115-,116+,117+,126+,127+,128+/m1/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.720n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of recombinant corticotropin releasing factor receptor 1 assayed using nonselective [125I]-labeled agonist [Tyr0,Glu1,Nle17]-sauvagine


J Med Chem 45: 4737-47 (2002)


Article DOI: 10.1021/jm0202122
BindingDB Entry DOI: 10.7270/Q2WQ04JR
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50158983
PNG
(CHEMBL439883 | E G P P I S I D L S L E L L R K M I...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@@H]1CCC(=O)N1)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C202H345N55O64S/c1-29-103(20)156(250-178(298)125(62-71-153(276)277)236-195(315)157(104(21)30-2)251-179(299)126(72-81-322-28)234-169(289)114(49-37-41-76-206)222-170(290)115(50-42-77-216-201(212)213)226-180(300)127(82-96(6)7)240-183(303)130(85-99(12)13)239-177(297)123(60-69-151(272)273)233-181(301)128(83-97(8)9)244-191(311)138(94-258)248-186(306)133(88-102(18)19)243-189(309)136(91-154(278)279)247-196(316)158(105(22)31-3)252-192(312)139(95-259)249-197(317)159(106(23)32-4)253-193(313)140-52-44-80-257(140)199(319)141-53-45-79-256(141)148(267)93-218-164(284)117-57-66-147(266)221-117)194(314)235-124(61-70-152(274)275)176(296)225-112(47-35-39-74-204)167(287)230-120(56-65-144(209)263)173(293)232-122(59-68-150(270)271)175(295)224-113(48-36-40-75-205)168(288)231-121(58-67-149(268)269)174(294)223-111(46-34-38-73-203)166(286)229-119(55-64-143(208)262)172(292)228-118(54-63-142(207)261)165(285)220-108(25)162(282)219-109(26)163(283)237-134(89-145(210)264)188(308)245-135(90-146(211)265)187(307)227-116(51-43-78-217-202(214)215)171(291)238-129(84-98(10)11)182(302)241-131(86-100(14)15)184(304)242-132(87-101(16)17)185(305)246-137(92-155(280)281)190(310)255-161(110(27)260)198(318)254-160(200(320)321)107(24)33-5/h96-141,156-161,258-260H,29-95,203-206H2,1-28H3,(H2,207,261)(H2,208,262)(H2,209,263)(H2,210,264)(H2,211,265)(H,218,284)(H,219,282)(H,220,285)(H,221,266)(H,222,290)(H,223,294)(H,224,295)(H,225,296)(H,226,300)(H,227,307)(H,228,292)(H,229,286)(H,230,287)(H,231,288)(H,232,293)(H,233,301)(H,234,289)(H,235,314)(H,236,315)(H,237,283)(H,238,291)(H,239,297)(H,240,303)(H,241,302)(H,242,304)(H,243,309)(H,244,311)(H,245,308)(H,246,305)(H,247,316)(H,248,306)(H,249,317)(H,250,298)(H,251,299)(H,252,312)(H,253,313)(H,254,318)(H,255,310)(H,268,269)(H,270,271)(H,272,273)(H,274,275)(H,276,277)(H,278,279)(H,280,281)(H,320,321)(H4,212,213,216)(H4,214,215,217)/t103-,104-,105-,106-,107-,108-,109-,110+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,156-,157-,158-,159-,160-,161-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.900n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of recombinant corticotropin releasing factor receptor 1 assayed using nonselective [125I]-labeled agonist [Tyr0,Glu1,Nle17]-sauvagine


J Med Chem 45: 4737-47 (2002)


Article DOI: 10.1021/jm0202122
BindingDB Entry DOI: 10.7270/Q2WQ04JR
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50119607
PNG
(CHEMBL440057 | E G P P I S I D L S L E L L R K M I...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](N)CO)[C@@H](C)CC)[C@@H](C)O)C(C)C)[C@@H](C)CC)C(O)=O
Show InChI InChI=1S/C208H343N59O64S2/c1-30-106(20)161(263-198(323)147-49-41-75-266(147)204(329)148-50-42-76-267(148)203(328)132(59-68-158(286)287)246-179(304)126(55-64-154(278)279)235-169(294)117(210)93-268)200(325)260-146(95-270)197(322)253-137(83-102(12)13)189(314)256-144(90-159(288)289)194(319)252-139(85-104(16)17)195(320)265-164(113(27)271)202(327)258-140(86-114-43-34-33-35-44-114)190(315)254-142(88-116-92-222-97-227-116)191(316)251-136(82-101(10)11)188(313)250-135(81-100(8)9)185(310)237-121(48-40-74-225-208(219)220)174(299)241-128(57-66-156(282)283)182(307)261-160(105(18)19)199(324)257-138(84-103(14)15)187(312)243-127(56-65-155(280)281)178(303)244-130(69-77-332-28)172(297)230-109(23)165(290)232-119(46-38-72-223-206(215)216)170(295)228-110(24)166(291)234-125(54-63-153(276)277)177(302)240-124(53-62-151(213)274)180(305)248-133(79-98(4)5)184(309)231-111(25)167(292)233-123(52-61-150(212)273)176(301)239-122(51-60-149(211)272)171(296)229-112(26)168(293)247-141(87-115-91-221-96-226-115)192(317)259-145(94-269)196(321)255-143(89-152(214)275)193(318)238-120(47-39-73-224-207(217)218)173(298)236-118(45-36-37-71-209)175(300)249-134(80-99(6)7)186(311)245-131(70-78-333-29)181(306)242-129(58-67-157(284)285)183(308)262-162(107(21)31-2)201(326)264-163(205(330)331)108(22)32-3/h33-35,43-44,91-92,96-113,117-148,160-164,268-271H,30-32,36-42,45-90,93-95,209-210H2,1-29H3,(H2,211,272)(H2,212,273)(H2,213,274)(H2,214,275)(H,221,226)(H,222,227)(H,228,295)(H,229,296)(H,230,297)(H,231,309)(H,232,290)(H,233,292)(H,234,291)(H,235,294)(H,236,298)(H,237,310)(H,238,318)(H,239,301)(H,240,302)(H,241,299)(H,242,306)(H,243,312)(H,244,303)(H,245,311)(H,246,304)(H,247,293)(H,248,305)(H,249,300)(H,250,313)(H,251,316)(H,252,319)(H,253,322)(H,254,315)(H,255,321)(H,256,314)(H,257,324)(H,258,327)(H,259,317)(H,260,325)(H,261,307)(H,262,308)(H,263,323)(H,264,326)(H,265,320)(H,276,277)(H,278,279)(H,280,281)(H,282,283)(H,284,285)(H,286,287)(H,288,289)(H,330,331)(H4,215,216,223)(H4,217,218,224)(H4,219,220,225)/t106-,107-,108-,109-,110-,111-,112-,113+,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,160-,161-,162-,163-,164-/m0/s1
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 0.990n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of recombinant corticotropin releasing factor receptor 1 assayed using nonselective [125I]-labeled agonist [Tyr0,Glu1,Nle17]-sauvagine


J Med Chem 45: 4737-47 (2002)


Article DOI: 10.1021/jm0202122
BindingDB Entry DOI: 10.7270/Q2WQ04JR
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50272638
PNG
(2-(4-chloro-2,6-dimethoxyphenyl)-4-methoxy-6-methy...)
Show SMILES CCCN(CCC)c1c(C)nc(nc1OC)-c1c(OC)cc(Cl)cc1OC
Show InChI InChI=1S/C20H28ClN3O3/c1-7-9-24(10-8-2)18-13(3)22-19(23-20(18)27-6)17-15(25-4)11-14(21)12-16(17)26-5/h11-12H,7-10H2,1-6H3
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1n/an/an/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Antagonist activity at CRF1 receptor expressed in mouse AtT20 cells assessed as inhibition of sauvagine-stimulated cAMP accumulation


Bioorg Med Chem Lett 18: 4486-90 (2008)


Article DOI: 10.1016/j.bmcl.2008.07.063
BindingDB Entry DOI: 10.7270/Q2NG4RJ4
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50300147
PNG
((S)-4-(1-Cyclopropyl-2-methoxyethyl)-6-[6-(difluor...)
Show SMILES COC[C@H](C1CC1)n1cc(Cl)nc(Nc2cc(C#N)c(OC(F)F)nc2C)c1=O
Show InChI InChI=1S/C18H18ClF2N5O3/c1-9-12(5-11(6-22)16(23-9)29-18(20)21)24-15-17(27)26(7-14(19)25-15)13(8-28-2)10-3-4-10/h5,7,10,13,18H,3-4,8H2,1-2H3,(H,24,25)/t13-/m1/s1
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Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Antagonist activity at CRF1 receptor in human Y79 cells assessed as inhibition of CRF-stimulated cAMP production after 30 mins by HTRF analysis


J Med Chem 52: 7653-68 (2009)


Article DOI: 10.1021/jm900716v
BindingDB Entry DOI: 10.7270/Q2CN740W
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50026956
PNG
(CHEMBL2370938)
Show SMILES CCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@](C)(CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(C)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCNC(C)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@](C)(CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O
Show InChI InChI=1S/C185H314N50O53/c1-28-32-50-110(207-153(260)112(51-36-41-72-186)208-157(264)116(56-46-77-200-182(194)195)212-171(278)129(83-98(13)14)230-180(287)184(26,89-99(15)16)234-176(283)131(85-109-91-198-93-202-109)226-172(279)130(84-108-48-34-33-35-49-108)225-175(282)135(92-236)229-170(277)128(82-97(11)12)224-174(281)133(87-144(252)253)205-107(25)238)165(272)231-147(102(20)30-3)179(286)220-124(64-71-143(250)251)166(273)232-148(103(21)31-4)178(285)219-123(63-70-142(248)249)164(271)211-113(52-37-42-73-187)154(261)215-119(59-66-137(191)240)160(267)218-121(61-68-140(244)245)162(269)210-114(53-38-43-74-188)155(262)216-120(60-67-139(242)243)161(268)209-115(54-39-44-75-189)156(263)217-122(62-69-141(246)247)163(270)214-118(58-65-136(190)239)152(259)204-104(22)150(257)203-105(23)151(258)206-111(55-40-45-76-199-106(24)237)158(265)227-132(86-138(192)241)173(280)213-117(57-47-78-201-183(196)197)159(266)221-125(79-94(5)6)167(274)222-126(80-95(7)8)168(275)223-127(81-96(9)10)169(276)228-134(88-145(254)255)177(284)235-185(27,90-100(17)18)181(288)233-146(149(193)256)101(19)29-2/h33-35,48-49,91,93-105,110-135,146-148,236H,28-32,36-47,50-90,92,186-189H2,1-27H3,(H2,190,239)(H2,191,240)(H2,192,241)(H2,193,256)(H,198,202)(H,199,237)(H,203,257)(H,204,259)(H,205,238)(H,206,258)(H,207,260)(H,208,264)(H,209,268)(H,210,269)(H,211,271)(H,212,278)(H,213,280)(H,214,270)(H,215,261)(H,216,262)(H,217,263)(H,218,267)(H,219,285)(H,220,286)(H,221,266)(H,222,274)(H,223,275)(H,224,281)(H,225,282)(H,226,279)(H,227,265)(H,228,276)(H,229,277)(H,230,287)(H,231,272)(H,232,273)(H,233,288)(H,234,283)(H,235,284)(H,242,243)(H,244,245)(H,246,247)(H,248,249)(H,250,251)(H,252,253)(H,254,255)(H4,194,195,200)(H4,196,197,201)/t101-,102-,103-,104-,105-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130+,131-,132-,133-,134-,135-,146-,147-,148-,184-,185-/m0/s1
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Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of recombinant corticotropin releasing factor receptor 1 assayed using nonselective [125I]-labeled agonist [Tyr0,Glu1,Nle17]-sauvagine


J Med Chem 45: 4737-47 (2002)


Article DOI: 10.1021/jm0202122
BindingDB Entry DOI: 10.7270/Q2WQ04JR
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50293912
PNG
((R)-5-chloro-1-(1-cyclopropyl-2-methoxyethyl)-3-(4...)
Show SMILES COC[C@@H](C1CC1)n1cc(Cl)nc(Nc2cc(C)c(OC)cc2C)c1=O
Show InChI InChI=1S/C19H24ClN3O3/c1-11-8-16(26-4)12(2)7-14(11)21-18-19(24)23(9-17(20)22-18)15(10-25-3)13-5-6-13/h7-9,13,15H,5-6,10H2,1-4H3,(H,21,22)/t15-/m0/s1
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Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Antagonist activity at CRF1 receptor in human Y79 cells assessed as inhibition of CRF-stimulated cAMP production by HTRF method


J Med Chem 52: 4173-91 (2009)


Article DOI: 10.1021/jm900301y
BindingDB Entry DOI: 10.7270/Q2G44Q9K
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50362277
PNG
(CHEMBL1939601)
Show SMILES CCC(CC)c1cc(C)n2nc(-c3c(C)cc(OC)cc3C)n(C)c(=O)c12
Show InChI InChI=1S/C22H29N3O2/c1-8-16(9-2)18-12-15(5)25-20(18)22(26)24(6)21(23-25)19-13(3)10-17(27-7)11-14(19)4/h10-12,16H,8-9H2,1-7H3
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Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]CRF from human CRF1 receptor expressed in CHO-K1 cells after 2 hrs by gamma counter


Bioorg Med Chem 20: 1122-38 (2012)


Article DOI: 10.1016/j.bmc.2011.11.015
BindingDB Entry DOI: 10.7270/Q2B27VQT
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50354028
PNG
(CHEMBL1830524)
Show SMILES CCC(CC)n1ccc2c(Nc3ccc(OC)cc3CC)nc3ccnn3c12
Show InChI InChI=1S/C22H27N5O/c1-5-15-14-17(28-4)8-9-19(15)24-21-18-11-13-26(16(6-2)7-3)22(18)27-20(25-21)10-12-23-27/h8-14,16H,5-7H2,1-4H3,(H,24,25)
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Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO-K1 cells after 2 hrs by gamma counting


Bioorg Med Chem 19: 5955-66 (2011)


Article DOI: 10.1016/j.bmc.2011.08.055
BindingDB Entry DOI: 10.7270/Q24X5862
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50362259
PNG
(CHEMBL1939570)
Show SMILES CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3C)n(C)c(=O)c12
Show InChI InChI=1S/C21H27N3O2/c1-7-15(8-2)18-12-14(4)24-19(18)21(25)23(5)20(22-24)17-10-9-16(26-6)11-13(17)3/h9-12,15H,7-8H2,1-6H3
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Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]CRF from human CRF1 receptor expressed in CHO-K1 cells after 2 hrs by gamma counter


Bioorg Med Chem 20: 1122-38 (2012)


Article DOI: 10.1016/j.bmc.2011.11.015
BindingDB Entry DOI: 10.7270/Q2B27VQT
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50132927
PNG
(Butyl-cyclopropylmethyl-[3-(2,4-dichloro-phenyl)-1...)
Show SMILES CCCCN(CC1CC1)c1cc(C)nc2c(nn(C)c12)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C22H26Cl2N4/c1-4-5-10-28(13-15-6-7-15)19-11-14(2)25-21-20(26-27(3)22(19)21)17-9-8-16(23)12-18(17)24/h8-9,11-12,15H,4-7,10,13H2,1-3H3
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Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Corticotropin releasing factor receptor 1-stimulated cAMP production


Bioorg Med Chem Lett 13: 3371-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00622-x
BindingDB Entry DOI: 10.7270/Q21C1W8F
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50351393
PNG
(CHEMBL1819083)
Show SMILES CCC(CC)Nc1c2CCCc2nc2c(c(C)nn12)-c1ccc(OC(F)F)cc1Cl
Show InChI InChI=1S/C22H25ClF2N4O/c1-4-13(5-2)26-20-16-7-6-8-18(16)27-21-19(12(3)28-29(20)21)15-10-9-14(11-17(15)23)30-22(24)25/h9-11,13,22,26H,4-8H2,1-3H3
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Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]CRF from human corticotropin-releasing factor receptor 1 expressed in CHO-K1 cells after 2 hrs by gamma counting


Bioorg Med Chem 19: 5432-45 (2011)


Article DOI: 10.1016/j.bmc.2011.07.055
BindingDB Entry DOI: 10.7270/Q2Z038JX
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50354027
PNG
(CHEMBL1830523)
Show SMILES CCC(CC)n1ccc2c(Nc3ccc(OC)cc3Cl)nc3ccnn3c12
Show InChI InChI=1S/C20H22ClN5O/c1-4-13(5-2)25-11-9-15-19(24-18-8-10-22-26(18)20(15)25)23-17-7-6-14(27-3)12-16(17)21/h6-13H,4-5H2,1-3H3,(H,23,24)
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Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO-K1 cells after 2 hrs by gamma counting


Bioorg Med Chem 19: 5955-66 (2011)


Article DOI: 10.1016/j.bmc.2011.08.055
BindingDB Entry DOI: 10.7270/Q24X5862
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50362291
PNG
(CHEMBL1939590)
Show SMILES CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3C)n(CC3CC3)c(=O)c12
Show InChI InChI=1S/C24H31N3O2/c1-6-18(7-2)21-13-16(4)27-22(21)24(28)26(14-17-8-9-17)23(25-27)20-11-10-19(29-5)12-15(20)3/h10-13,17-18H,6-9,14H2,1-5H3
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Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]CRF from human CRF1 receptor expressed in CHO-K1 cells after 2 hrs by gamma counter


Bioorg Med Chem 20: 1122-38 (2012)


Article DOI: 10.1016/j.bmc.2011.11.015
BindingDB Entry DOI: 10.7270/Q2B27VQT
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50026954
PNG
(CHEMBL2370929)
Show SMILES CCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@](C)(CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(C)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCNC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@](C)(CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O
Show InChI InChI=1S/C184H310N50O55/c1-26-30-48-108(206-152(261)109(49-34-39-72-185)207-156(265)114(54-44-77-199-181(193)194)212-170(279)127(82-96(11)12)229-179(288)183(24,88-97(13)14)233-175(284)129(84-107-90-197-92-201-107)225-171(280)128(83-106-46-32-31-33-47-106)224-174(283)133(91-235)228-169(278)126(81-95(9)10)223-173(282)131(86-143(253)254)204-105(23)237)165(274)230-146(100(18)28-3)178(287)220-123(63-71-142(251)252)166(275)231-147(101(19)29-4)177(286)219-122(62-70-141(249)250)163(272)211-110(50-35-40-73-186)153(262)214-117(57-65-135(190)239)159(268)218-120(60-68-139(245)246)161(270)210-111(51-36-41-74-187)154(263)216-119(59-67-138(243)244)160(269)209-112(52-37-42-75-188)155(264)217-121(61-69-140(247)248)162(271)215-118(58-66-137(241)242)151(260)203-102(20)149(258)202-103(21)150(259)205-116(56-64-134(189)238)164(273)226-130(85-136(191)240)172(281)213-115(55-45-78-200-182(195)196)157(266)208-113(53-38-43-76-198-104(22)236)158(267)221-124(79-93(5)6)167(276)222-125(80-94(7)8)168(277)227-132(87-144(255)256)176(285)234-184(25,89-98(15)16)180(289)232-145(148(192)257)99(17)27-2/h31-33,46-47,90,92-103,108-133,145-147,235H,26-30,34-45,48-89,91,185-188H2,1-25H3,(H2,189,238)(H2,190,239)(H2,191,240)(H2,192,257)(H,197,201)(H,198,236)(H,202,258)(H,203,260)(H,204,237)(H,205,259)(H,206,261)(H,207,265)(H,208,266)(H,209,269)(H,210,270)(H,211,272)(H,212,279)(H,213,281)(H,214,262)(H,215,271)(H,216,263)(H,217,264)(H,218,268)(H,219,286)(H,220,287)(H,221,267)(H,222,276)(H,223,282)(H,224,283)(H,225,280)(H,226,273)(H,227,277)(H,228,278)(H,229,288)(H,230,274)(H,231,275)(H,232,289)(H,233,284)(H,234,285)(H,241,242)(H,243,244)(H,245,246)(H,247,248)(H,249,250)(H,251,252)(H,253,254)(H,255,256)(H4,193,194,199)(H4,195,196,200)/t99-,100-,101-,102-,103-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128+,129-,130-,131-,132-,133-,145-,146-,147-,183-,184-/m0/s1
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Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of recombinant corticotropin releasing factor receptor 1 assayed using nonselective [125I]-labeled agonist [Tyr0,Glu1,Nle17]-sauvagine


J Med Chem 45: 4737-47 (2002)


Article DOI: 10.1021/jm0202122
BindingDB Entry DOI: 10.7270/Q2WQ04JR
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50362269
PNG
(CHEMBL1939593)
Show SMILES CCC(CC)c1cc(C)n2nc(-c3ccc(OC)nc3C)n(C)c(=O)c12
Show InChI InChI=1S/C20H26N4O2/c1-7-14(8-2)16-11-12(3)24-18(16)20(25)23(5)19(22-24)15-9-10-17(26-6)21-13(15)4/h9-11,14H,7-8H2,1-6H3
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Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]CRF from human CRF1 receptor expressed in CHO-K1 cells after 2 hrs by gamma counter


Bioorg Med Chem 20: 1122-38 (2012)


Article DOI: 10.1016/j.bmc.2011.11.015
BindingDB Entry DOI: 10.7270/Q2B27VQT
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50362260
PNG
(CHEMBL1939571)
Show SMILES CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3Cl)n(C)c(=O)c12
Show InChI InChI=1S/C20H24ClN3O2/c1-6-13(7-2)16-10-12(3)24-18(16)20(25)23(4)19(22-24)15-9-8-14(26-5)11-17(15)21/h8-11,13H,6-7H2,1-5H3
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Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]CRF from human CRF1 receptor expressed in CHO-K1 cells after 2 hrs by gamma counter


Bioorg Med Chem 20: 1122-38 (2012)


Article DOI: 10.1016/j.bmc.2011.11.015
BindingDB Entry DOI: 10.7270/Q2B27VQT
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50351387
PNG
(CHEMBL1819077)
Show SMILES CCC(CC)Nc1c2CCCc2nc2c(c(C)nn12)-c1ccc(OC)cc1Cl
Show InChI InChI=1S/C22H27ClN4O/c1-5-14(6-2)24-21-17-8-7-9-19(17)25-22-20(13(3)26-27(21)22)16-11-10-15(28-4)12-18(16)23/h10-12,14,24H,5-9H2,1-4H3
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n/an/a 4n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]CRF from human corticotropin-releasing factor receptor 1 expressed in CHO-K1 cells after 2 hrs by gamma counting


Bioorg Med Chem 19: 5432-45 (2011)


Article DOI: 10.1016/j.bmc.2011.07.055
BindingDB Entry DOI: 10.7270/Q2Z038JX
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50423382
PNG
(CHEMBL251386)
Show SMILES CCCC(CCC)n1cc2CCN(c3ccc(cc3C)C#N)c3nc(C)cc1c23
Show InChI InChI=1S/C25H30N4/c1-5-7-21(8-6-2)29-16-20-11-12-28(22-10-9-19(15-26)13-17(22)3)25-24(20)23(29)14-18(4)27-25/h9-10,13-14,16,21H,5-8,11-12H2,1-4H3
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n/an/a 4n/an/an/an/an/an/a



GlaxoSmithkline

Curated by ChEMBL


Assay Description
Displacement of [125I]CRF from human recombinant CRF1 receptor expressed in CHO cell membrane


Bioorg Med Chem Lett 17: 5218-21 (2007)


Article DOI: 10.1016/j.bmcl.2007.06.077
BindingDB Entry DOI: 10.7270/Q2P55PS1
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50116105
PNG
(3-(6-(dimethylamino)-4-methylpyridin-3-yl)-2,5-dim...)
Show SMILES CCCN(CCC)c1cc(C)nc2c(c(C)nn12)-c1cnc(cc1C)N(C)C
Show InChI InChI=1S/C22H32N6/c1-8-10-27(11-9-2)20-13-16(4)24-22-21(17(5)25-28(20)22)18-14-23-19(26(6)7)12-15(18)3/h12-14H,8-11H2,1-7H3
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n/an/a 4n/an/an/an/an/an/a



Eisai Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at CRF1 receptor in human IMR32 cells assessed as inhibition of CRF-induced intracellular cAMP accumulation after 30 mins by immu...


J Med Chem 55: 8450-63 (2012)


Article DOI: 10.1021/jm300864p
BindingDB Entry DOI: 10.7270/Q2KD202P
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50234480
PNG
(CHEMBL4069551)
Show SMILES CCC(CC)c1ccc(Cl)c2nc(Oc3c(C)cc(Cl)cc3Cl)n(C)c12
Show InChI InChI=1S/C20H21Cl3N2O/c1-5-12(6-2)14-7-8-15(22)17-18(14)25(4)20(24-17)26-19-11(3)9-13(21)10-16(19)23/h7-10,12H,5-6H2,1-4H3
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n/an/a 4.10n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of ovine [125-I]-CRF from human CRF1 receptor expressed in CHO cell membranes preincubated for 1 hr followed by [125I]-CRF addition meas...


Bioorg Med Chem 25: 1556-1570 (2017)


Article DOI: 10.1016/j.bmc.2016.11.011
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50362279
PNG
(CHEMBL1939603)
Show SMILES CCC(C)c1cc(C)n2nc(-c3c(C)cc(OC)cc3C)n(C)c(=O)c12
Show InChI InChI=1S/C21H27N3O2/c1-8-12(2)17-11-15(5)24-19(17)21(25)23(6)20(22-24)18-13(3)9-16(26-7)10-14(18)4/h9-12H,8H2,1-7H3
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n/an/a 4.20n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]CRF from human CRF1 receptor expressed in CHO-K1 cells after 2 hrs by gamma counter


Bioorg Med Chem 20: 1122-38 (2012)


Article DOI: 10.1016/j.bmc.2011.11.015
BindingDB Entry DOI: 10.7270/Q2B27VQT
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50354036
PNG
(CHEMBL1828890)
Show SMILES CCCN(CCC)c1c(CC)c(Nc2ccc(OC)cc2Cl)nc2ccnn12
Show InChI InChI=1S/C21H28ClN5O/c1-5-12-26(13-6-2)21-16(7-3)20(25-19-10-11-23-27(19)21)24-18-9-8-15(28-4)14-17(18)22/h8-11,14H,5-7,12-13H2,1-4H3,(H,24,25)
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n/an/a 4.20n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO-K1 cells after 2 hrs by gamma counting


Bioorg Med Chem 19: 5955-66 (2011)


Article DOI: 10.1016/j.bmc.2011.08.055
BindingDB Entry DOI: 10.7270/Q24X5862
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50362286
PNG
(CHEMBL1939585)
Show SMILES CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3Cl)n(CCO)c(=O)c12
Show InChI InChI=1S/C21H26ClN3O3/c1-5-14(6-2)17-11-13(3)25-19(17)21(27)24(9-10-26)20(23-25)16-8-7-15(28-4)12-18(16)22/h7-8,11-12,14,26H,5-6,9-10H2,1-4H3
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n/an/a 4.40n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]CRF from human CRF1 receptor expressed in CHO-K1 cells after 2 hrs by gamma counter


Bioorg Med Chem 20: 1122-38 (2012)


Article DOI: 10.1016/j.bmc.2011.11.015
BindingDB Entry DOI: 10.7270/Q2B27VQT
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50354015
PNG
(CHEMBL1828900)
Show SMILES CCCN(CCC)c1cc(nc2ccnn12)N(CC=C)c1ccc(OC)cc1Cl
Show InChI InChI=1S/C22H28ClN5O/c1-5-12-26(13-6-2)22-16-21(25-20-10-11-24-28(20)22)27(14-7-3)19-9-8-17(29-4)15-18(19)23/h7-11,15-16H,3,5-6,12-14H2,1-2,4H3
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n/an/a 4.40n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO-K1 cells after 2 hrs by gamma counting


Bioorg Med Chem 19: 5955-66 (2011)


Article DOI: 10.1016/j.bmc.2011.08.055
BindingDB Entry DOI: 10.7270/Q24X5862
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50362270
PNG
(CHEMBL1939594)
Show SMILES CCC(CC)c1cc(C)n2nc(-c3ccc(OC(F)F)nc3C)n(C)c(=O)c12
Show InChI InChI=1S/C20H24F2N4O2/c1-6-13(7-2)15-10-11(3)26-17(15)19(27)25(5)18(24-26)14-8-9-16(23-12(14)4)28-20(21)22/h8-10,13,20H,6-7H2,1-5H3
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n/an/a 4.5n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]CRF from human CRF1 receptor expressed in CHO-K1 cells after 2 hrs by gamma counter


Bioorg Med Chem 20: 1122-38 (2012)


Article DOI: 10.1016/j.bmc.2011.11.015
BindingDB Entry DOI: 10.7270/Q2B27VQT
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50362284
PNG
(CHEMBL1939583)
Show SMILES CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3Cl)n(CC)c(=O)c12
Show InChI InChI=1S/C21H26ClN3O2/c1-6-14(7-2)17-11-13(4)25-19(17)21(26)24(8-3)20(23-25)16-10-9-15(27-5)12-18(16)22/h9-12,14H,6-8H2,1-5H3
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n/an/a 4.60n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]CRF from human CRF1 receptor expressed in CHO-K1 cells after 2 hrs by gamma counter


Bioorg Med Chem 20: 1122-38 (2012)


Article DOI: 10.1016/j.bmc.2011.11.015
BindingDB Entry DOI: 10.7270/Q2B27VQT
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50354029
PNG
(CHEMBL1830525)
Show SMILES CCC(CC)n1ccc2c(Nc3ccc(Cl)cc3CC)nc3ccnn3c12
Show InChI InChI=1S/C21H24ClN5/c1-4-14-13-15(22)7-8-18(14)24-20-17-10-12-26(16(5-2)6-3)21(17)27-19(25-20)9-11-23-27/h7-13,16H,4-6H2,1-3H3,(H,24,25)
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n/an/a 4.70n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO-K1 cells after 2 hrs by gamma counting


Bioorg Med Chem 19: 5955-66 (2011)


Article DOI: 10.1016/j.bmc.2011.08.055
BindingDB Entry DOI: 10.7270/Q24X5862
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50293910
PNG
((S)-5-chloro-1-(1-cyclopropylethyl)-3-(2,6-dichlor...)
Show SMILES C[C@@H](C1CC1)n1cc(Cl)nc(Nc2c(Cl)cc(OC(F)F)cc2Cl)c1=O
Show InChI InChI=1S/C16H14Cl3F2N3O2/c1-7(8-2-3-8)24-6-12(19)22-14(15(24)25)23-13-10(17)4-9(5-11(13)18)26-16(20)21/h4-8,16H,2-3H2,1H3,(H,22,23)/t7-/m0/s1
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n/an/a 4.90n/an/an/an/an/an/a



Bristol-Myers Squibb Company

Curated by ChEMBL


Assay Description
Antagonist activity at CRF1 receptor in human Y-79 cells assessed as inhibition of CRF-induced cAMP production after 30 mins by HTRF analysis


J Med Chem 52: 4161-72 (2009)


Article DOI: 10.1021/jm900302q
BindingDB Entry DOI: 10.7270/Q2WW7JM0
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50362273
PNG
(CHEMBL1939597)
Show SMILES CCC(C)c1cc(C)n2nc(-c3ccc(OC)cc3Cl)n(C)c(=O)c12
Show InChI InChI=1S/C19H22ClN3O2/c1-6-11(2)15-9-12(3)23-17(15)19(24)22(4)18(21-23)14-8-7-13(25-5)10-16(14)20/h7-11H,6H2,1-5H3
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n/an/a 4.90n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]CRF from human CRF1 receptor expressed in CHO-K1 cells after 2 hrs by gamma counter


Bioorg Med Chem 20: 1122-38 (2012)


Article DOI: 10.1016/j.bmc.2011.11.015
BindingDB Entry DOI: 10.7270/Q2B27VQT
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50132901
PNG
(CHEMBL445075 | Cyclopropylmethyl-[3-(2,4-dichloro-...)
Show SMILES CCCN(CC1CC1)c1cc(C)nc2c(nn(C)c12)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C21H24Cl2N4/c1-4-9-27(12-14-5-6-14)18-10-13(2)24-20-19(25-26(3)21(18)20)16-8-7-15(22)11-17(16)23/h7-8,10-11,14H,4-6,9,12H2,1-3H3
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n/an/a 5n/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Compound was tested to inhibit Corticotropin releasing factor receptor 1-stimulated c-AMP production


Bioorg Med Chem Lett 13: 3367-70 (2003)


Article DOI: 10.1016/s0960-894x(03)00621-8
BindingDB Entry DOI: 10.7270/Q2542N05
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50132898
PNG
(CHEMBL115142 | Dibutyl-[3-(2,4-dichloro-phenyl)-1,...)
Show SMILES CCCCN(CCCC)c1cc(C)nc2c(nn(C)c12)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C22H28Cl2N4/c1-5-7-11-28(12-8-6-2)19-13-15(3)25-21-20(26-27(4)22(19)21)17-10-9-16(23)14-18(17)24/h9-10,13-14H,5-8,11-12H2,1-4H3
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n/an/a 5n/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of Corticotropin releasing factor receptor 1-stimulated cAMP production


Bioorg Med Chem Lett 13: 3371-4 (2003)


Article DOI: 10.1016/s0960-894x(03)00622-x
BindingDB Entry DOI: 10.7270/Q21C1W8F
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50362271
PNG
(CHEMBL1939595)
Show SMILES CCC(C)c1cc(C)n2nc(-c3ccc(OC)cc3C)n(C)c(=O)c12
Show InChI InChI=1S/C20H25N3O2/c1-7-12(2)17-11-14(4)23-18(17)20(24)22(5)19(21-23)16-9-8-15(25-6)10-13(16)3/h8-12H,7H2,1-6H3
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n/an/a 5n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]CRF from human CRF1 receptor expressed in CHO-K1 cells after 2 hrs by gamma counter


Bioorg Med Chem 20: 1122-38 (2012)


Article DOI: 10.1016/j.bmc.2011.11.015
BindingDB Entry DOI: 10.7270/Q2B27VQT
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50362280
PNG
(CHEMBL1939592)
Show SMILES CCC(CC)c1cc(C)n2nc(-c3cnc(OC(F)F)cc3C)n(C)c(=O)c12
Show InChI InChI=1S/C20H24F2N4O2/c1-6-13(7-2)14-9-12(4)26-17(14)19(27)25(5)18(24-26)15-10-23-16(8-11(15)3)28-20(21)22/h8-10,13,20H,6-7H2,1-5H3
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n/an/a 5.30n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]CRF from human CRF1 receptor expressed in CHO-K1 cells after 2 hrs by gamma counter


Bioorg Med Chem 20: 1122-38 (2012)


Article DOI: 10.1016/j.bmc.2011.11.015
BindingDB Entry DOI: 10.7270/Q2B27VQT
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50362288
PNG
(CHEMBL1939587)
Show SMILES CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3C)n(C3CC3)c(=O)c12
Show InChI InChI=1S/C23H29N3O2/c1-6-16(7-2)20-13-15(4)26-21(20)23(27)25(17-8-9-17)22(24-26)19-11-10-18(28-5)12-14(19)3/h10-13,16-17H,6-9H2,1-5H3
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n/an/a 5.70n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]CRF from human CRF1 receptor expressed in CHO-K1 cells after 2 hrs by gamma counter


Bioorg Med Chem 20: 1122-38 (2012)


Article DOI: 10.1016/j.bmc.2011.11.015
BindingDB Entry DOI: 10.7270/Q2B27VQT
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50026976
PNG
(CHEMBL2370933)
Show SMILES CCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@](C)(CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(C)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC1=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NC(CC(O)=O)C(=O)N[C@@](C)(CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O
Show InChI InChI=1S/C182H305N49O54/c1-25-29-47-106(203-150(257)107(48-33-38-71-183)204-154(261)112(53-43-76-196-179(190)191)209-168(275)125(81-95(11)12)226-177(284)181(23,87-96(13)14)230-173(280)127(83-105-89-194-91-198-105)222-169(276)126(82-104-45-31-30-32-46-104)221-172(279)131(90-232)225-167(274)124(80-94(9)10)220-171(278)129(85-141(249)250)201-103(22)233)163(270)227-144(99(18)27-3)176(283)217-121(62-70-140(247)248)164(271)228-145(100(19)28-4)175(282)216-120(61-69-139(245)246)161(268)208-108(49-34-39-72-184)151(258)211-114(55-63-132(187)234)157(264)215-118(59-67-137(241)242)159(266)207-109(50-35-40-73-185)152(259)213-117(58-66-136(239)240)158(265)206-110(51-36-41-74-186)153(260)214-119(60-68-138(243)244)160(267)212-116(57-65-135(237)238)149(256)200-101(20)147(254)199-102(21)148(255)202-115-56-64-134(236)195-75-42-37-52-111(205-155(262)113(54-44-77-197-180(192)193)210-170(277)128(84-133(188)235)223-162(115)269)156(263)218-122(78-92(5)6)165(272)219-123(79-93(7)8)166(273)224-130(86-142(251)252)174(281)231-182(24,88-97(15)16)178(285)229-143(146(189)253)98(17)26-2/h30-32,45-46,89,91-102,106-131,143-145,232H,25-29,33-44,47-88,90,183-186H2,1-24H3,(H2,187,234)(H2,188,235)(H2,189,253)(H,194,198)(H,195,236)(H,199,254)(H,200,256)(H,201,233)(H,202,255)(H,203,257)(H,204,261)(H,205,262)(H,206,265)(H,207,266)(H,208,268)(H,209,275)(H,210,277)(H,211,258)(H,212,267)(H,213,259)(H,214,260)(H,215,264)(H,216,282)(H,217,283)(H,218,263)(H,219,272)(H,220,278)(H,221,279)(H,222,276)(H,223,269)(H,224,273)(H,225,274)(H,226,284)(H,227,270)(H,228,271)(H,229,285)(H,230,280)(H,231,281)(H,237,238)(H,239,240)(H,241,242)(H,243,244)(H,245,246)(H,247,248)(H,249,250)(H,251,252)(H4,190,191,196)(H4,192,193,197)/t98-,99-,100-,101-,102-,106-,107-,108-,109-,110-,111+,112-,113+,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126+,127-,128-,129-,130?,131-,143-,144-,145-,181+,182-/m0/s1
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n/an/a 5.90n/an/an/an/an/an/a



Salk Institute

Curated by ChEMBL


Assay Description
Inhibition of recombinant corticotropin releasing factor receptor 1 assayed using nonselective [125I]-labeled agonist [Tyr0,Glu1,Nle17]-sauvagine


J Med Chem 45: 4737-47 (2002)


Article DOI: 10.1021/jm0202122
BindingDB Entry DOI: 10.7270/Q2WQ04JR
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50362289
PNG
(CHEMBL1939588)
Show SMILES CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3Cl)n(C3CC3)c(=O)c12
Show InChI InChI=1S/C22H26ClN3O2/c1-5-14(6-2)18-11-13(3)26-20(18)22(27)25(15-7-8-15)21(24-26)17-10-9-16(28-4)12-19(17)23/h9-12,14-15H,5-8H2,1-4H3
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n/an/a 5.90n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]CRF from human CRF1 receptor expressed in CHO-K1 cells after 2 hrs by gamma counter


Bioorg Med Chem 20: 1122-38 (2012)


Article DOI: 10.1016/j.bmc.2011.11.015
BindingDB Entry DOI: 10.7270/Q2B27VQT
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50351394
PNG
(CHEMBL1819084)
Show SMILES CCC(CC)Nc1cc(C)nc2c(c(C)nn12)-c1ccc(OC)cc1Cl
Show InChI InChI=1S/C20H25ClN4O/c1-6-14(7-2)23-18-10-12(3)22-20-19(13(4)24-25(18)20)16-9-8-15(26-5)11-17(16)21/h8-11,14,23H,6-7H2,1-5H3
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n/an/a 6n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]CRF from human corticotropin-releasing factor receptor 1 expressed in CHO-K1 cells after 2 hrs by gamma counting


Bioorg Med Chem 19: 5432-45 (2011)


Article DOI: 10.1016/j.bmc.2011.07.055
BindingDB Entry DOI: 10.7270/Q2Z038JX
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50354038
PNG
(CHEMBL1830527)
Show SMILES CCC(CC)n1ccc2c(Nc3c(C)cc(C)cc3C)nc3ccnn3c12
Show InChI InChI=1S/C22H27N5/c1-6-17(7-2)26-11-9-18-21(24-19-8-10-23-27(19)22(18)26)25-20-15(4)12-14(3)13-16(20)5/h8-13,17H,6-7H2,1-5H3,(H,24,25)
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n/an/a 6.10n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO-K1 cells after 2 hrs by gamma counting


Bioorg Med Chem 19: 5955-66 (2011)


Article DOI: 10.1016/j.bmc.2011.08.055
BindingDB Entry DOI: 10.7270/Q24X5862
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM29490
PNG
(Pyrazolo[1,5-a]-1,3,5-triazine, 13-15)
Show SMILES CC[C@@H](C)Nc1nc(C)nc2c(c(C)nn12)-c1ccc(OC)nc1C
Show InChI InChI=1S/C18H24N6O/c1-7-10(2)19-18-22-13(5)21-17-16(12(4)23-24(17)18)14-8-9-15(25-6)20-11(14)3/h8-10H,7H2,1-6H3,(H,19,21,22)/t10-/m1/s1
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n/an/a 6.10n/an/an/an/an/an/a



Bristol-Myers Squibb Co.

Curated by ChEMBL


Assay Description
Antagonist activity at human CRF1 receptor


Drug Metab Dispos 40: 1093-103 (2012)


Article DOI: 10.1124/dmd.111.043596
BindingDB Entry DOI: 10.7270/Q2C24Z52
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50354031
PNG
(CHEMBL1830528)
Show SMILES CCC(CC)n1ccc2c(Oc3ccc(CC)cc3OC)nc3ccnn3c12
Show InChI InChI=1S/C22H26N4O2/c1-5-15-8-9-18(19(14-15)27-4)28-21-17-11-13-25(16(6-2)7-3)22(17)26-20(24-21)10-12-23-26/h8-14,16H,5-7H2,1-4H3
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n/an/a 7n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO-K1 cells after 2 hrs by gamma counting


Bioorg Med Chem 19: 5955-66 (2011)


Article DOI: 10.1016/j.bmc.2011.08.055
BindingDB Entry DOI: 10.7270/Q24X5862
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50272704
PNG
(2-(4-chloro-2,6-dimethoxyphenyl)-4-methoxy-6-methy...)
Show SMILES CCC(CC)Oc1c(C)nc(nc1OC)-c1c(OC)cc(Cl)cc1OC
Show InChI InChI=1S/C19H25ClN2O4/c1-7-13(8-2)26-17-11(3)21-18(22-19(17)25-6)16-14(23-4)9-12(20)10-15(16)24-5/h9-10,13H,7-8H2,1-6H3
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n/an/a 7n/an/an/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Antagonist activity at CRF1 receptor expressed in mouse AtT20 cells assessed as inhibition of sauvagine-stimulated cAMP accumulation


Bioorg Med Chem Lett 18: 4486-90 (2008)


Article DOI: 10.1016/j.bmcl.2008.07.063
BindingDB Entry DOI: 10.7270/Q2NG4RJ4
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50351396
PNG
(CHEMBL1819086)
Show SMILES CCC(CC)Nc1c2OCCc2nc2c(c(C)nn12)-c1ccc(OC)cc1Cl
Show InChI InChI=1S/C21H25ClN4O2/c1-5-13(6-2)23-21-19-17(9-10-28-19)24-20-18(12(3)25-26(20)21)15-8-7-14(27-4)11-16(15)22/h7-8,11,13,23H,5-6,9-10H2,1-4H3
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n/an/a 7n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]CRF from human corticotropin-releasing factor receptor 1 expressed in CHO-K1 cells after 2 hrs by gamma counting


Bioorg Med Chem 19: 5432-45 (2011)


Article DOI: 10.1016/j.bmc.2011.07.055
BindingDB Entry DOI: 10.7270/Q2Z038JX
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50354030
PNG
(CHEMBL1830526)
Show SMILES CCC(CC)n1ccc2c(Cc3c(C)cc(C)cc3C)nc3ccnn3c12
Show InChI InChI=1S/C23H28N4/c1-6-18(7-2)26-11-9-19-21(25-22-8-10-24-27(22)23(19)26)14-20-16(4)12-15(3)13-17(20)5/h8-13,18H,6-7,14H2,1-5H3
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n/an/a 7.10n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO-K1 cells after 2 hrs by gamma counting


Bioorg Med Chem 19: 5955-66 (2011)


Article DOI: 10.1016/j.bmc.2011.08.055
BindingDB Entry DOI: 10.7270/Q24X5862
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50398565
PNG
(CHEMBL2179195)
Show SMILES CCCCN(C1CCOCC1)c1c(OC)nn2c(csc12)-c1c(OC)cc(COCC)cc1OC
Show InChI InChI=1S/C26H37N3O5S/c1-6-8-11-28(19-9-12-34-13-10-19)24-25(32-5)27-29-20(17-35-26(24)29)23-21(30-3)14-18(16-33-7-2)15-22(23)31-4/h14-15,17,19H,6-13,16H2,1-5H3
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n/an/a 7.10n/an/an/an/an/an/a



Eisai Co., Ltd.

Curated by ChEMBL


Assay Description
Antagonist activity at CRF1 receptor in human IMR32 cells assessed as inhibition of CRF-induced intracellular cAMP accumulation after 30 mins by immu...


J Med Chem 55: 8450-63 (2012)


Article DOI: 10.1021/jm300864p
BindingDB Entry DOI: 10.7270/Q2KD202P
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50362266
PNG
(CHEMBL1939577)
Show SMILES CCC(CC)c1cc(C)n2nc(c(C)cc12)-c1cnc(cc1C)N(C)C
Show InChI InChI=1S/C22H30N4/c1-8-17(9-2)18-12-16(5)26-20(18)10-15(4)22(24-26)19-13-23-21(25(6)7)11-14(19)3/h10-13,17H,8-9H2,1-7H3
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n/an/a 7.40n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]CRF from human CRF1 receptor expressed in CHO-K1 cells after 2 hrs by gamma counter


Bioorg Med Chem 20: 1122-38 (2012)


Article DOI: 10.1016/j.bmc.2011.11.015
BindingDB Entry DOI: 10.7270/Q2B27VQT
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50354033
PNG
(CHEMBL1828887)
Show SMILES CCC(CC)Nc1c(C)c(Nc2ccc(OC)cc2Cl)nc2ccnn12
Show InChI InChI=1S/C19H24ClN5O/c1-5-13(6-2)22-19-12(3)18(24-17-9-10-21-25(17)19)23-16-8-7-14(26-4)11-15(16)20/h7-11,13,22H,5-6H2,1-4H3,(H,23,24)
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n/an/a 7.40n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO-K1 cells after 2 hrs by gamma counting


Bioorg Med Chem 19: 5955-66 (2011)


Article DOI: 10.1016/j.bmc.2011.08.055
BindingDB Entry DOI: 10.7270/Q24X5862
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50234477
PNG
(CHEMBL4087369)
Show SMILES CCCC(CCC)c1ccc(Cl)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12
Show InChI InChI=1S/C23H29Cl2N3O/c1-6-8-15(9-7-2)17-10-11-18(25)21-22(17)28(4)23(27-21)26-20-14(3)12-16(24)13-19(20)29-5/h10-13,15H,6-9H2,1-5H3,(H,26,27)
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n/an/a 7.40n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of ovine [125-I]-CRF from human CRF1 receptor expressed in CHO cell membranes preincubated for 1 hr followed by [125I]-CRF addition meas...


Bioorg Med Chem 25: 1556-1570 (2017)


Article DOI: 10.1016/j.bmc.2016.11.011
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50161874
PNG
(CHEMBL3794475)
Show SMILES CCN(CC)c1ccc(C)c2nc(Nc3c(C)cc(Cl)cc3OC)n(C)c12
Show InChI InChI=1S/C21H27ClN4O/c1-7-26(8-2)16-10-9-13(3)19-20(16)25(5)21(24-19)23-18-14(4)11-15(22)12-17(18)27-6/h9-12H,7-8H2,1-6H3,(H,23,24)
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n/an/a 7.60n/an/an/an/an/an/a



Takeda Pharmaceutical Company Ltd.

Curated by ChEMBL


Assay Description
Displacement of [125I]-CRF from human CRF1 receptor expressed in CHO cellular membrane fraction after 1.5 hrs by liquid scintillation counting method


J Med Chem 59: 2551-66 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01715
BindingDB Entry DOI: 10.7270/Q24F1SNR
More data for this
Ligand-Target Pair
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