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Compile Data Set for Download or QSAR

Found 87 hits of ec50 for UniProtKB: P34998   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50087703
PNG
(CHEMBL427807 | Urocortin-human(DNPSLSIDLTFHLLRTLLE...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H]1CCCN1C(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(N)=O
Show InChI InChI=1S/C204H337N63O64/c1-28-100(20)154(262-191(323)140(90-271)257-180(312)127(75-96(12)13)247-189(321)138(88-269)259-192(324)141-52-42-70-267(141)199(331)136(83-146(210)279)255-163(295)111(205)81-150(286)287)193(325)254-135(85-152(290)291)185(317)246-129(77-98(16)17)187(319)266-159(107(27)274)198(330)253-131(79-109-45-35-32-36-46-109)181(313)248-132(80-110-86-222-91-228-110)183(315)245-126(74-95(10)11)178(310)243-124(72-93(6)7)176(308)235-116(51-41-69-227-204(220)221)174(306)265-158(106(26)273)197(329)251-128(76-97(14)15)179(311)244-125(73-94(8)9)177(309)239-122(58-64-149(284)285)170(302)242-123(71-92(4)5)175(307)230-104(24)161(293)231-114(49-39-67-225-202(216)217)173(305)264-157(105(25)272)196(328)241-119(55-61-144(208)277)171(303)256-137(87-268)188(320)240-117(53-59-142(206)275)166(298)234-113(48-38-66-224-201(214)215)165(297)238-121(57-63-148(282)283)168(300)233-112(47-37-65-223-200(212)213)164(296)229-103(23)162(294)232-120(56-62-147(280)281)167(299)237-118(54-60-143(207)276)169(301)249-133(82-145(209)278)184(316)236-115(50-40-68-226-203(218)219)172(304)261-156(102(22)30-3)195(327)263-155(101(21)29-2)194(326)252-130(78-108-43-33-31-34-44-108)182(314)250-134(84-151(288)289)186(318)258-139(89-270)190(322)260-153(99(18)19)160(211)292/h31-36,43-46,86,91-107,111-141,153-159,268-274H,28-30,37-42,47-85,87-90,205H2,1-27H3,(H2,206,275)(H2,207,276)(H2,208,277)(H2,209,278)(H2,210,279)(H2,211,292)(H,222,228)(H,229,296)(H,230,307)(H,231,293)(H,232,294)(H,233,300)(H,234,298)(H,235,308)(H,236,316)(H,237,299)(H,238,297)(H,239,309)(H,240,320)(H,241,328)(H,242,302)(H,243,310)(H,244,311)(H,245,315)(H,246,317)(H,247,321)(H,248,313)(H,249,301)(H,250,314)(H,251,329)(H,252,326)(H,253,330)(H,254,325)(H,255,295)(H,256,303)(H,257,312)(H,258,318)(H,259,324)(H,260,322)(H,261,304)(H,262,323)(H,263,327)(H,264,305)(H,265,306)(H,266,319)(H,280,281)(H,282,283)(H,284,285)(H,286,287)(H,288,289)(H,290,291)(H4,212,213,223)(H4,214,215,224)(H4,216,217,225)(H4,218,219,226)(H4,220,221,227)/t100-,101-,102-,103-,104-,105+,106+,107+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141+,153-,154-,155-,156-,157-,158-,159-/m0/s1
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n/an/an/an/a 0.220n/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Activity of peptidic agonists on corticotropin releasing factor receptor receptor using agonist-stimulated adenylate cyclase assay

J Med Chem 43: 1641-60 (2000)


Article DOI: 10.1021/jm990590f
BindingDB Entry DOI: 10.7270/Q29S1RRP
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50362270
PNG
(CHEMBL1939594)
Show SMILES CCC(CC)c1cc(C)n2nc(-c3ccc(OC(F)F)nc3C)n(C)c(=O)c12
Show InChI InChI=1S/C20H24F2N4O2/c1-6-13(7-2)15-10-11(3)26-17(15)19(27)25(5)18(24-26)14-8-9-16(23-12(14)4)28-20(21)22/h8-10,13,20H,6-7H2,1-5H3
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n/an/an/an/a 0.300n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CRF1 receptor expressed in CHO-K1 cells assessed as CRF-stimulated cAMP accumulation by enzyme immunoassay

Bioorg Med Chem 20: 1122-38 (2012)


Article DOI: 10.1016/j.bmc.2011.11.015
BindingDB Entry DOI: 10.7270/Q2B27VQT
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50362277
PNG
(CHEMBL1939601)
Show SMILES CCC(CC)c1cc(C)n2nc(-c3c(C)cc(OC)cc3C)n(C)c(=O)c12
Show InChI InChI=1S/C22H29N3O2/c1-8-16(9-2)18-12-15(5)25-20(18)22(26)24(6)21(23-25)19-13(3)10-17(27-7)11-14(19)4/h10-12,16H,8-9H2,1-7H3
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n/an/an/an/a 0.600n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CRF1 receptor expressed in CHO-K1 cells assessed as CRF-stimulated cAMP accumulation by enzyme immunoassay

Bioorg Med Chem 20: 1122-38 (2012)


Article DOI: 10.1016/j.bmc.2011.11.015
BindingDB Entry DOI: 10.7270/Q2B27VQT
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50362284
PNG
(CHEMBL1939583)
Show SMILES CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3Cl)n(CC)c(=O)c12
Show InChI InChI=1S/C21H26ClN3O2/c1-6-14(7-2)17-11-13(4)25-19(17)21(26)24(8-3)20(23-25)16-10-9-15(27-5)12-18(16)22/h9-12,14H,6-8H2,1-5H3
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n/an/an/an/a 0.700n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CRF1 receptor expressed in CHO-K1 cells assessed as CRF-stimulated cAMP accumulation by enzyme immunoassay

Bioorg Med Chem 20: 1122-38 (2012)


Article DOI: 10.1016/j.bmc.2011.11.015
BindingDB Entry DOI: 10.7270/Q2B27VQT
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50354027
PNG
(CHEMBL1830523)
Show SMILES CCC(CC)n1ccc2c(Nc3ccc(OC)cc3Cl)nc3ccnn3c12
Show InChI InChI=1S/C20H22ClN5O/c1-4-13(5-2)25-11-9-15-19(24-18-8-10-22-26(18)20(15)25)23-17-7-6-14(27-3)12-16(17)21/h6-13H,4-5H2,1-3H3,(H,23,24)
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n/an/an/an/a 0.700n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CRF1 receptor expressed in CHO-K1 cells assessed as inhibition of CRF-induced cAMP accumulation after 15 mins by cAMP en...

Bioorg Med Chem 19: 5955-66 (2011)


Article DOI: 10.1016/j.bmc.2011.08.055
BindingDB Entry DOI: 10.7270/Q24X5862
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50362289
PNG
(CHEMBL1939588)
Show SMILES CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3Cl)n(C3CC3)c(=O)c12
Show InChI InChI=1S/C22H26ClN3O2/c1-5-14(6-2)18-11-13(3)26-20(18)22(27)25(15-7-8-15)21(24-26)17-10-9-16(28-4)12-19(17)23/h9-12,14-15H,5-8H2,1-4H3
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n/an/an/an/a 1n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CRF1 receptor expressed in CHO-K1 cells assessed as CRF-stimulated cAMP accumulation by enzyme immunoassay

Bioorg Med Chem 20: 1122-38 (2012)


Article DOI: 10.1016/j.bmc.2011.11.015
BindingDB Entry DOI: 10.7270/Q2B27VQT
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50362273
PNG
(CHEMBL1939597)
Show SMILES CCC(C)c1cc(C)n2nc(-c3ccc(OC)cc3Cl)n(C)c(=O)c12
Show InChI InChI=1S/C19H22ClN3O2/c1-6-11(2)15-9-12(3)23-17(15)19(24)22(4)18(21-23)14-8-7-13(25-5)10-16(14)20/h7-11H,6H2,1-5H3
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n/an/an/an/a 1.10n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CRF1 receptor expressed in CHO-K1 cells assessed as CRF-stimulated cAMP accumulation by enzyme immunoassay

Bioorg Med Chem 20: 1122-38 (2012)


Article DOI: 10.1016/j.bmc.2011.11.015
BindingDB Entry DOI: 10.7270/Q2B27VQT
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50276840
PNG
(CHEMBL4160471)
Show SMILES CCCCN(CC)c1nc(C)nc2n(-c3c(C)cc(C)cc3C)c(=N)sc12
Show InChI InChI=1S/C21H29N5S/c1-7-9-10-25(8-2)19-18-20(24-16(6)23-19)26(21(22)27-18)17-14(4)11-13(3)12-15(17)5/h11-12,22H,7-10H2,1-6H3
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n/an/an/an/a 1.10n/an/an/an/a



South Dakota State University

Curated by ChEMBL


Assay Description
Antagonist activity at human CRFR1 expressed in HEK293 cells assessed as inhibition of sauvagine-induced cAMP accumulation by measuring sauvagine EC5...

Eur J Med Chem 138: 900-908 (2017)


BindingDB Entry DOI: 10.7270/Q2R78HRZ
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50362269
PNG
(CHEMBL1939593)
Show SMILES CCC(CC)c1cc(C)n2nc(-c3ccc(OC)nc3C)n(C)c(=O)c12
Show InChI InChI=1S/C20H26N4O2/c1-7-14(8-2)16-11-12(3)24-18(16)20(25)23(5)19(22-24)15-9-10-17(26-6)21-13(15)4/h9-11,14H,7-8H2,1-6H3
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n/an/an/an/a 1.10n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CRF1 receptor expressed in CHO-K1 cells assessed as CRF-stimulated cAMP accumulation by enzyme immunoassay

Bioorg Med Chem 20: 1122-38 (2012)


Article DOI: 10.1016/j.bmc.2011.11.015
BindingDB Entry DOI: 10.7270/Q2B27VQT
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50362260
PNG
(CHEMBL1939571)
Show SMILES CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3Cl)n(C)c(=O)c12
Show InChI InChI=1S/C20H24ClN3O2/c1-6-13(7-2)16-10-12(3)24-18(16)20(25)23(4)19(22-24)15-9-8-14(26-5)11-17(15)21/h8-11,13H,6-7H2,1-5H3
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n/an/an/an/a 1.20n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CRF1 receptor expressed in CHO-K1 cells assessed as CRF-stimulated cAMP accumulation by enzyme immunoassay

Bioorg Med Chem 20: 1122-38 (2012)


Article DOI: 10.1016/j.bmc.2011.11.015
BindingDB Entry DOI: 10.7270/Q2B27VQT
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50362283
PNG
(CHEMBL1939582)
Show SMILES CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3C)n(CC)c(=O)c12
Show InChI InChI=1S/C22H29N3O2/c1-7-16(8-2)19-13-15(5)25-20(19)22(26)24(9-3)21(23-25)18-11-10-17(27-6)12-14(18)4/h10-13,16H,7-9H2,1-6H3
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Minase Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CRF1 receptor expressed in CHO-K1 cells assessed as CRF-stimulated cAMP accumulation by enzyme immunoassay

Bioorg Med Chem 20: 1122-38 (2012)


Article DOI: 10.1016/j.bmc.2011.11.015
BindingDB Entry DOI: 10.7270/Q2B27VQT
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50362259
PNG
(CHEMBL1939570)
Show SMILES CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3C)n(C)c(=O)c12
Show InChI InChI=1S/C21H27N3O2/c1-7-15(8-2)18-12-14(4)24-19(18)21(25)23(5)20(22-24)17-10-9-16(26-6)11-13(17)3/h9-12,15H,7-8H2,1-6H3
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n/an/an/an/a 1.70n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CRF1 receptor expressed in CHO-K1 cells assessed as CRF-stimulated cAMP accumulation by enzyme immunoassay

Bioorg Med Chem 20: 1122-38 (2012)


Article DOI: 10.1016/j.bmc.2011.11.015
BindingDB Entry DOI: 10.7270/Q2B27VQT
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50362261
PNG
(CHEMBL1939572)
Show SMILES CCC(CC)c1cc(C)n2nc(c(C)cc12)-c1ccc(C)cc1C
Show InChI InChI=1S/C22H28N2/c1-7-18(8-2)20-13-17(6)24-21(20)12-16(5)22(23-24)19-10-9-14(3)11-15(19)4/h9-13,18H,7-8H2,1-6H3
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n/an/an/an/a 1.80n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CRF1 receptor expressed in CHO-K1 cells assessed as CRF-stimulated cAMP accumulation by enzyme immunoassay

Bioorg Med Chem 20: 1122-38 (2012)


Article DOI: 10.1016/j.bmc.2011.11.015
BindingDB Entry DOI: 10.7270/Q2B27VQT
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50362265
PNG
(CHEMBL1939576)
Show SMILES CCC(CC)c1cc(C)n2nc(c(C)cc12)-c1cc(OC)c(OC)cc1CC
Show InChI InChI=1S/C24H32N2O2/c1-8-17(9-2)19-12-16(5)26-21(19)11-15(4)24(25-26)20-14-23(28-7)22(27-6)13-18(20)10-3/h11-14,17H,8-10H2,1-7H3
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n/an/an/an/a 1.90n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CRF1 receptor expressed in CHO-K1 cells assessed as CRF-stimulated cAMP accumulation by enzyme immunoassay

Bioorg Med Chem 20: 1122-38 (2012)


Article DOI: 10.1016/j.bmc.2011.11.015
BindingDB Entry DOI: 10.7270/Q2B27VQT
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50362271
PNG
(CHEMBL1939595)
Show SMILES CCC(C)c1cc(C)n2nc(-c3ccc(OC)cc3C)n(C)c(=O)c12
Show InChI InChI=1S/C20H25N3O2/c1-7-12(2)17-11-14(4)23-18(17)20(24)22(5)19(21-23)16-9-8-15(25-6)10-13(16)3/h8-12H,7H2,1-6H3
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n/an/an/an/a 2.40n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CRF1 receptor expressed in CHO-K1 cells assessed as CRF-stimulated cAMP accumulation by enzyme immunoassay

Bioorg Med Chem 20: 1122-38 (2012)


Article DOI: 10.1016/j.bmc.2011.11.015
BindingDB Entry DOI: 10.7270/Q2B27VQT
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50362264
PNG
(CHEMBL1939575)
Show SMILES CCC(CC)c1cc(C)n2nc(c(C)cc12)-c1cc2OCOc2cc1C
Show InChI InChI=1S/C22H26N2O2/c1-6-16(7-2)18-10-15(5)24-19(18)8-14(4)22(23-24)17-11-21-20(9-13(17)3)25-12-26-21/h8-11,16H,6-7,12H2,1-5H3
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n/an/an/an/a 2.5n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CRF1 receptor expressed in CHO-K1 cells assessed as CRF-stimulated cAMP accumulation by enzyme immunoassay

Bioorg Med Chem 20: 1122-38 (2012)


Article DOI: 10.1016/j.bmc.2011.11.015
BindingDB Entry DOI: 10.7270/Q2B27VQT
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50362280
PNG
(CHEMBL1939592)
Show SMILES CCC(CC)c1cc(C)n2nc(-c3cnc(OC(F)F)cc3C)n(C)c(=O)c12
Show InChI InChI=1S/C20H24F2N4O2/c1-6-13(7-2)14-9-12(4)26-17(14)19(27)25(5)18(24-26)15-10-23-16(8-11(15)3)28-20(21)22/h8-10,13,20H,6-7H2,1-5H3
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n/an/an/an/a 3.20n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CRF1 receptor expressed in CHO-K1 cells assessed as CRF-stimulated cAMP accumulation by enzyme immunoassay

Bioorg Med Chem 20: 1122-38 (2012)


Article DOI: 10.1016/j.bmc.2011.11.015
BindingDB Entry DOI: 10.7270/Q2B27VQT
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50362262
PNG
(CHEMBL1939573)
Show SMILES CCC(CC)c1cc(C)n2nc(c(C)cc12)-c1cc(C)c(C)cc1C
Show InChI InChI=1S/C23H30N2/c1-8-19(9-2)21-13-18(7)25-22(21)12-17(6)23(24-25)20-11-15(4)14(3)10-16(20)5/h10-13,19H,8-9H2,1-7H3
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n/an/an/an/a 3.30n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CRF1 receptor expressed in CHO-K1 cells assessed as CRF-stimulated cAMP accumulation by enzyme immunoassay

Bioorg Med Chem 20: 1122-38 (2012)


Article DOI: 10.1016/j.bmc.2011.11.015
BindingDB Entry DOI: 10.7270/Q2B27VQT
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50087711
PNG
(CHEMBL429560 | Sauvagine-frog(QGPPISIDLSLELLRKMIEI...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)CNC(=O)[C@@H](N)CCC(N)=O)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)C(N)=O
Show InChI InChI=1S/C202H349N57O63S/c1-29-103(20)156(162(214)284)252-199(321)161(110(27)262)257-191(313)137(92-155(282)283)248-186(308)132(87-101(16)17)244-185(307)131(86-100(14)15)243-183(305)129(84-98(10)11)240-172(294)117(51-43-78-220-202(217)218)229-188(310)135(90-147(213)268)247-189(311)134(89-146(212)267)239-164(286)109(26)222-163(285)108(25)223-166(288)118(55-64-143(209)264)230-173(295)119(56-65-144(210)265)231-167(289)112(46-34-38-73-203)225-175(297)121(58-67-149(270)271)233-169(291)114(48-36-40-75-205)226-176(298)122(59-68-150(272)273)234-174(296)120(57-66-145(211)266)232-168(290)113(47-35-39-74-204)227-177(299)124(61-70-152(276)277)237-195(317)157(104(21)30-2)253-179(301)125(62-71-153(278)279)238-196(318)158(105(22)31-3)254-180(302)126(72-81-323-28)236-170(292)115(49-37-41-76-206)224-171(293)116(50-42-77-219-201(215)216)228-181(303)127(82-96(6)7)242-184(306)130(85-99(12)13)241-178(300)123(60-69-151(274)275)235-182(304)128(83-97(8)9)246-192(314)138(94-260)250-187(309)133(88-102(18)19)245-190(312)136(91-154(280)281)249-197(319)159(106(23)32-4)255-193(315)139(95-261)251-198(320)160(107(24)33-5)256-194(316)140-52-44-80-259(140)200(322)141-53-45-79-258(141)148(269)93-221-165(287)111(207)54-63-142(208)263/h96-141,156-161,260-262H,29-95,203-207H2,1-28H3,(H2,208,263)(H2,209,264)(H2,210,265)(H2,211,266)(H2,212,267)(H2,213,268)(H2,214,284)(H,221,287)(H,222,285)(H,223,288)(H,224,293)(H,225,297)(H,226,298)(H,227,299)(H,228,303)(H,229,310)(H,230,295)(H,231,289)(H,232,290)(H,233,291)(H,234,296)(H,235,304)(H,236,292)(H,237,317)(H,238,318)(H,239,286)(H,240,294)(H,241,300)(H,242,306)(H,243,305)(H,244,307)(H,245,312)(H,246,314)(H,247,311)(H,248,308)(H,249,319)(H,250,309)(H,251,320)(H,252,321)(H,253,301)(H,254,302)(H,255,315)(H,256,316)(H,257,313)(H,270,271)(H,272,273)(H,274,275)(H,276,277)(H,278,279)(H,280,281)(H,282,283)(H4,215,216,219)(H4,217,218,220)/t103-,104-,105-,106-,107-,108-,109-,110+,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141+,156-,157-,158-,159-,160-,161-/m0/s1
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n/an/an/an/a 3.40n/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Activity of peptidic agonists on corticotropin releasing factor receptor receptor using agonist-stimulated adenylate cyclase assay

J Med Chem 43: 1641-60 (2000)


Article DOI: 10.1021/jm990590f
BindingDB Entry DOI: 10.7270/Q29S1RRP
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50362286
PNG
(CHEMBL1939585)
Show SMILES CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3Cl)n(CCO)c(=O)c12
Show InChI InChI=1S/C21H26ClN3O3/c1-5-14(6-2)17-11-13(3)25-19(17)21(27)24(9-10-26)20(23-25)16-8-7-15(28-4)12-18(16)22/h7-8,11-12,14,26H,5-6,9-10H2,1-4H3
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Minase Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CRF1 receptor expressed in CHO-K1 cells assessed as CRF-stimulated cAMP accumulation by enzyme immunoassay

Bioorg Med Chem 20: 1122-38 (2012)


Article DOI: 10.1016/j.bmc.2011.11.015
BindingDB Entry DOI: 10.7270/Q2B27VQT
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50362279
PNG
(CHEMBL1939603)
Show SMILES CCC(C)c1cc(C)n2nc(-c3c(C)cc(OC)cc3C)n(C)c(=O)c12
Show InChI InChI=1S/C21H27N3O2/c1-8-12(2)17-11-15(5)24-19(17)21(25)23(6)20(22-24)18-13(3)9-16(26-7)10-14(18)4/h9-12H,8H2,1-7H3
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Minase Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CRF1 receptor expressed in CHO-K1 cells assessed as CRF-stimulated cAMP accumulation by enzyme immunoassay

Bioorg Med Chem 20: 1122-38 (2012)


Article DOI: 10.1016/j.bmc.2011.11.015
BindingDB Entry DOI: 10.7270/Q2B27VQT
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50087704
PNG
(CHEMBL265635 | r/h-CRF(SEEPPISLDLTFHLLREVLEMARAEQL...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](N)CO)[C@@H](C)CC)C(C)O)C(C)C)[C@@H](C)CC)C(N)=O
Show InChI InChI=1S/C208H344N60O63S2/c1-30-106(20)161(165(215)291)263-202(328)163(108(22)32-3)264-184(310)129(58-67-157(285)286)243-182(308)131(70-78-333-29)246-187(313)134(80-99(6)7)250-176(302)118(45-36-37-71-209)237-174(300)120(47-39-73-225-207(218)219)239-194(320)143(89-152(214)276)256-197(323)145(94-270)260-193(319)141(87-115-91-222-96-227-115)248-169(295)112(26)230-172(298)122(51-60-149(211)273)240-177(303)123(52-61-150(212)274)234-168(294)111(25)232-185(311)133(79-98(4)5)249-181(307)124(53-62-151(213)275)241-178(304)125(54-63-153(277)278)235-167(293)110(24)229-171(297)119(46-38-72-224-206(216)217)233-166(292)109(23)231-173(299)130(69-77-332-28)245-179(305)127(56-65-155(281)282)244-188(314)138(84-103(14)15)258-200(326)160(105(18)19)262-183(309)128(57-66-156(283)284)242-175(301)121(48-40-74-226-208(220)221)238-186(312)135(81-100(8)9)251-189(315)136(82-101(10)11)252-192(318)142(88-116-92-223-97-228-116)255-191(317)140(86-114-43-34-33-35-44-114)259-203(329)164(113(27)272)266-196(322)139(85-104(16)17)253-195(321)144(90-159(289)290)257-190(316)137(83-102(12)13)254-198(324)146(95-271)261-201(327)162(107(21)31-2)265-199(325)147-49-41-75-267(147)205(331)148-50-42-76-268(148)204(330)132(59-68-158(287)288)247-180(306)126(55-64-154(279)280)236-170(296)117(210)93-269/h33-35,43-44,91-92,96-113,117-148,160-164,269-272H,30-32,36-42,45-90,93-95,209-210H2,1-29H3,(H2,211,273)(H2,212,274)(H2,213,275)(H2,214,276)(H2,215,291)(H,222,227)(H,223,228)(H,229,297)(H,230,298)(H,231,299)(H,232,311)(H,233,292)(H,234,294)(H,235,293)(H,236,296)(H,237,300)(H,238,312)(H,239,320)(H,240,303)(H,241,304)(H,242,301)(H,243,308)(H,244,314)(H,245,305)(H,246,313)(H,247,306)(H,248,295)(H,249,307)(H,250,302)(H,251,315)(H,252,318)(H,253,321)(H,254,324)(H,255,317)(H,256,323)(H,257,316)(H,258,326)(H,259,329)(H,260,319)(H,261,327)(H,262,309)(H,263,328)(H,264,310)(H,265,325)(H,266,322)(H,277,278)(H,279,280)(H,281,282)(H,283,284)(H,285,286)(H,287,288)(H,289,290)(H4,216,217,224)(H4,218,219,225)(H4,220,221,226)/t106-,107-,108-,109+,110+,111-,112-,113?,117-,118-,119-,120-,121-,122+,123-,124-,125-,126-,127-,128-,129-,130-,131-,132+,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148+,160-,161-,162-,163-,164-/m0/s1
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n/an/an/an/a 3.5n/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Activity of peptidic agonists on corticotropin releasing factor receptor receptor using agonist-stimulated adenylate cyclase assay

J Med Chem 43: 1641-60 (2000)


Article DOI: 10.1021/jm990590f
BindingDB Entry DOI: 10.7270/Q29S1RRP
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50354028
PNG
(CHEMBL1830524)
Show SMILES CCC(CC)n1ccc2c(Nc3ccc(OC)cc3CC)nc3ccnn3c12
Show InChI InChI=1S/C22H27N5O/c1-5-15-14-17(28-4)8-9-19(15)24-21-18-11-13-26(16(6-2)7-3)22(18)27-20(25-21)10-12-23-27/h8-14,16H,5-7H2,1-4H3,(H,24,25)
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Minase Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CRF1 receptor expressed in CHO-K1 cells assessed as inhibition of CRF-induced cAMP accumulation after 15 mins by cAMP en...

Bioorg Med Chem 19: 5955-66 (2011)


Article DOI: 10.1016/j.bmc.2011.08.055
BindingDB Entry DOI: 10.7270/Q24X5862
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50362288
PNG
(CHEMBL1939587)
Show SMILES CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3C)n(C3CC3)c(=O)c12
Show InChI InChI=1S/C23H29N3O2/c1-6-16(7-2)20-13-15(4)26-21(20)23(27)25(17-8-9-17)22(24-26)19-11-10-18(28-5)12-14(19)3/h10-13,16-17H,6-9H2,1-5H3
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n/an/an/an/a 3.70n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CRF1 receptor expressed in CHO-K1 cells assessed as CRF-stimulated cAMP accumulation by enzyme immunoassay

Bioorg Med Chem 20: 1122-38 (2012)


Article DOI: 10.1016/j.bmc.2011.11.015
BindingDB Entry DOI: 10.7270/Q2B27VQT
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50354029
PNG
(CHEMBL1830525)
Show SMILES CCC(CC)n1ccc2c(Nc3ccc(Cl)cc3CC)nc3ccnn3c12
Show InChI InChI=1S/C21H24ClN5/c1-4-14-13-15(22)7-8-18(14)24-20-17-10-12-26(16(5-2)6-3)21(17)27-19(25-20)9-11-23-27/h7-13,16H,4-6H2,1-3H3,(H,24,25)
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n/an/an/an/a 3.90n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CRF1 receptor expressed in CHO-K1 cells assessed as inhibition of CRF-induced cAMP accumulation after 15 mins by cAMP en...

Bioorg Med Chem 19: 5955-66 (2011)


Article DOI: 10.1016/j.bmc.2011.08.055
BindingDB Entry DOI: 10.7270/Q24X5862
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50354035
PNG
(CHEMBL1828889)
Show SMILES CCCN(CCC)c1c(C)c(Nc2ccc(OC)cc2Cl)nc2ccnn12
Show InChI InChI=1S/C20H26ClN5O/c1-5-11-25(12-6-2)20-14(3)19(24-18-9-10-22-26(18)20)23-17-8-7-15(27-4)13-16(17)21/h7-10,13H,5-6,11-12H2,1-4H3,(H,23,24)
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n/an/an/an/a 4n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CRF1 receptor expressed in CHO-K1 cells assessed as inhibition of CRF-induced cAMP accumulation after 15 mins by cAMP en...

Bioorg Med Chem 19: 5955-66 (2011)


Article DOI: 10.1016/j.bmc.2011.08.055
BindingDB Entry DOI: 10.7270/Q24X5862
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50351396
PNG
(CHEMBL1819086)
Show SMILES CCC(CC)Nc1c2OCCc2nc2c(c(C)nn12)-c1ccc(OC)cc1Cl
Show InChI InChI=1S/C21H25ClN4O2/c1-5-13(6-2)23-21-19-17(9-10-28-19)24-20-18(12(3)25-26(20)21)15-8-7-14(27-4)11-16(15)22/h7-8,11,13,23H,5-6,9-10H2,1-4H3
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Minase Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human corticotropin-releasing factor receptor 1 expressed in CHO-K1 cells assessed as inhibition of CRF-induced cAMP productio...

Bioorg Med Chem 19: 5432-45 (2011)


Article DOI: 10.1016/j.bmc.2011.07.055
BindingDB Entry DOI: 10.7270/Q2Z038JX
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50362282
PNG
(CHEMBL1939581)
Show SMILES CCC(CC)c1cc(C)n2nc([nH]c(=O)c12)-c1ccc(OC)cc1Cl
Show InChI InChI=1S/C19H22ClN3O2/c1-5-12(6-2)15-9-11(3)23-17(15)19(24)21-18(22-23)14-8-7-13(25-4)10-16(14)20/h7-10,12H,5-6H2,1-4H3,(H,21,22,24)
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Minase Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CRF1 receptor expressed in CHO-K1 cells assessed as CRF-stimulated cAMP accumulation by enzyme immunoassay

Bioorg Med Chem 20: 1122-38 (2012)


Article DOI: 10.1016/j.bmc.2011.11.015
BindingDB Entry DOI: 10.7270/Q2B27VQT
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50354038
PNG
(CHEMBL1830527)
Show SMILES CCC(CC)n1ccc2c(Nc3c(C)cc(C)cc3C)nc3ccnn3c12
Show InChI InChI=1S/C22H27N5/c1-6-17(7-2)26-11-9-18-21(24-19-8-10-23-27(19)22(18)26)25-20-15(4)12-14(3)13-16(20)5/h8-13,17H,6-7H2,1-5H3,(H,24,25)
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n/an/an/an/a 4.10n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CRF1 receptor expressed in CHO-K1 cells assessed as inhibition of CRF-induced cAMP accumulation after 15 mins by cAMP en...

Bioorg Med Chem 19: 5955-66 (2011)


Article DOI: 10.1016/j.bmc.2011.08.055
BindingDB Entry DOI: 10.7270/Q24X5862
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50362285
PNG
(CHEMBL1939584)
Show SMILES CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3C)n(CCO)c(=O)c12
Show InChI InChI=1S/C22H29N3O3/c1-6-16(7-2)19-13-15(4)25-20(19)22(27)24(10-11-26)21(23-25)18-9-8-17(28-5)12-14(18)3/h8-9,12-13,16,26H,6-7,10-11H2,1-5H3
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n/an/an/an/a 4.20n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CRF1 receptor expressed in CHO-K1 cells assessed as CRF-stimulated cAMP accumulation by enzyme immunoassay

Bioorg Med Chem 20: 1122-38 (2012)


Article DOI: 10.1016/j.bmc.2011.11.015
BindingDB Entry DOI: 10.7270/Q2B27VQT
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50354018
PNG
(CHEMBL1830514)
Show SMILES CCCN(CCC)c1cc(nc2ccnn12)N(COC)c1ccc(OC)cc1Cl
Show InChI InChI=1S/C21H28ClN5O2/c1-5-11-25(12-6-2)21-14-20(24-19-9-10-23-27(19)21)26(15-28-3)18-8-7-16(29-4)13-17(18)22/h7-10,13-14H,5-6,11-12,15H2,1-4H3
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n/an/an/an/a 4.40n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CRF1 receptor expressed in CHO-K1 cells assessed as inhibition of CRF-induced cAMP accumulation after 15 mins by cAMP en...

Bioorg Med Chem 19: 5955-66 (2011)


Article DOI: 10.1016/j.bmc.2011.08.055
BindingDB Entry DOI: 10.7270/Q24X5862
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50362278
PNG
(CHEMBL1939602)
Show SMILES COc1cc(C)c(c(C)c1)-c1nn2c(C)cc(C(C)C)c2c(=O)n1C
Show InChI InChI=1S/C20H25N3O2/c1-11(2)16-10-14(5)23-18(16)20(24)22(6)19(21-23)17-12(3)8-15(25-7)9-13(17)4/h8-11H,1-7H3
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n/an/an/an/a 4.5n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CRF1 receptor expressed in CHO-K1 cells assessed as CRF-stimulated cAMP accumulation by enzyme immunoassay

Bioorg Med Chem 20: 1122-38 (2012)


Article DOI: 10.1016/j.bmc.2011.11.015
BindingDB Entry DOI: 10.7270/Q2B27VQT
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50362258
PNG
(CHEMBL1939569)
Show SMILES CCC(CC)c1cc(C)n2nc(c(C)cc12)-c1ccc(OC)cc1C
Show InChI InChI=1S/C22H28N2O/c1-7-17(8-2)20-13-16(5)24-21(20)12-15(4)22(23-24)19-10-9-18(25-6)11-14(19)3/h9-13,17H,7-8H2,1-6H3
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n/an/an/an/a 4.90n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CRF1 receptor expressed in CHO-K1 cells assessed as CRF-stimulated cAMP accumulation by enzyme immunoassay

Bioorg Med Chem 20: 1122-38 (2012)


Article DOI: 10.1016/j.bmc.2011.11.015
BindingDB Entry DOI: 10.7270/Q2B27VQT
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50362291
PNG
(CHEMBL1939590)
Show SMILES CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3C)n(CC3CC3)c(=O)c12
Show InChI InChI=1S/C24H31N3O2/c1-6-18(7-2)21-13-16(4)27-22(21)24(28)26(14-17-8-9-17)23(25-27)20-11-10-19(29-5)12-15(20)3/h10-13,17-18H,6-9,14H2,1-5H3
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n/an/an/an/a 5n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CRF1 receptor expressed in CHO-K1 cells assessed as CRF-stimulated cAMP accumulation by enzyme immunoassay

Bioorg Med Chem 20: 1122-38 (2012)


Article DOI: 10.1016/j.bmc.2011.11.015
BindingDB Entry DOI: 10.7270/Q2B27VQT
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50362287
PNG
(CHEMBL1939586)
Show SMILES CCC(CC)c1cc(C)n2nc(-c3ccc(OC)cc3C)n(C(C)C)c(=O)c12
Show InChI InChI=1S/C23H31N3O2/c1-8-17(9-2)20-13-16(6)26-21(20)23(27)25(14(3)4)22(24-26)19-11-10-18(28-7)12-15(19)5/h10-14,17H,8-9H2,1-7H3
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n/an/an/an/a 5.10n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CRF1 receptor expressed in CHO-K1 cells assessed as CRF-stimulated cAMP accumulation by enzyme immunoassay

Bioorg Med Chem 20: 1122-38 (2012)


Article DOI: 10.1016/j.bmc.2011.11.015
BindingDB Entry DOI: 10.7270/Q2B27VQT
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50362274
PNG
(CHEMBL1939598)
Show SMILES CCC(CC)c1cc(C)n2nc(-c3ccc(nc3C)N(C)C)n(C)c(=O)c12
Show InChI InChI=1S/C21H29N5O/c1-8-15(9-2)17-12-13(3)26-19(17)21(27)25(7)20(23-26)16-10-11-18(24(5)6)22-14(16)4/h10-12,15H,8-9H2,1-7H3
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n/an/an/an/a 5.5n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CRF1 receptor expressed in CHO-K1 cells assessed as CRF-stimulated cAMP accumulation by enzyme immunoassay

Bioorg Med Chem 20: 1122-38 (2012)


Article DOI: 10.1016/j.bmc.2011.11.015
BindingDB Entry DOI: 10.7270/Q2B27VQT
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50354031
PNG
(CHEMBL1830528)
Show SMILES CCC(CC)n1ccc2c(Oc3ccc(CC)cc3OC)nc3ccnn3c12
Show InChI InChI=1S/C22H26N4O2/c1-5-15-8-9-18(19(14-15)27-4)28-21-17-11-13-25(16(6-2)7-3)22(17)26-20(24-21)10-12-23-26/h8-14,16H,5-7H2,1-4H3
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n/an/an/an/a 5.60n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CRF1 receptor expressed in CHO-K1 cells assessed as inhibition of CRF-induced cAMP accumulation after 15 mins by cAMP en...

Bioorg Med Chem 19: 5955-66 (2011)


Article DOI: 10.1016/j.bmc.2011.08.055
BindingDB Entry DOI: 10.7270/Q24X5862
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50087706
PNG
(CHEMBL265847 | Urotensin-1-sucker fish(NDDPPISIDLT...)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)NC(CC(O)=O)C(=O)C(CC(O)=O)NC(=O)C(N)CC(N)=O)[C@@H](C)CC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(N)=O
Show InChI InChI=1S/C210H340N62O67S2/c1-26-103(17)162(200(333)249-124(58-64-155(288)289)181(314)258-138(86-148(215)278)193(326)244-122(56-62-153(284)285)178(311)239-116(44-35-69-228-206(219)220)175(308)243-121(55-61-152(282)283)179(312)242-120(54-60-146(213)276)172(305)234-107(21)169(302)232-94-151(281)236-130(77-97(5)6)185(318)259-140(88-150(217)280)192(325)241-117(45-36-70-229-207(221)222)174(307)238-115(43-33-34-68-211)176(309)255-135(83-111-50-52-113(275)53-51-111)189(322)252-133(80-100(11)12)188(321)260-141(91-159(296)297)195(328)245-125(59-65-156(290)291)183(316)265-161(102(15)16)168(218)301)266-182(315)119(47-38-72-231-209(225)226)237-170(303)108(22)235-173(306)126(66-75-340-24)246-180(313)123(57-63-154(286)287)248-201(334)163(104(18)27-2)267-184(317)127(67-76-341-25)247-194(327)139(87-149(216)279)257-177(310)118(46-37-71-230-208(223)224)240-186(319)131(78-98(7)8)251-187(320)132(79-99(9)10)253-191(324)137(84-112-93-227-96-233-112)256-190(323)136(82-110-41-31-30-32-42-110)261-204(337)166(109(23)274)270-197(330)134(81-101(13)14)254-196(329)142(92-160(298)299)262-202(335)164(105(19)28-3)268-198(331)143(95-273)263-203(336)165(106(20)29-4)269-199(332)144-48-39-73-271(144)205(338)145-49-40-74-272(145)210(339)264-129(90-158(294)295)167(300)128(89-157(292)293)250-171(304)114(212)85-147(214)277/h30-32,41-42,50-53,93,96-109,114-145,161-166,273-275H,26-29,33-40,43-49,54-92,94-95,211-212H2,1-25H3,(H2,213,276)(H2,214,277)(H2,215,278)(H2,216,279)(H2,217,280)(H2,218,301)(H,227,233)(H,232,302)(H,234,305)(H,235,306)(H,236,281)(H,237,303)(H,238,307)(H,239,311)(H,240,319)(H,241,325)(H,242,312)(H,243,308)(H,244,326)(H,245,328)(H,246,313)(H,247,327)(H,248,334)(H,249,333)(H,250,304)(H,251,320)(H,252,322)(H,253,324)(H,254,329)(H,255,309)(H,256,323)(H,257,310)(H,258,314)(H,259,318)(H,260,321)(H,261,337)(H,262,335)(H,263,336)(H,264,339)(H,265,316)(H,266,315)(H,267,317)(H,268,331)(H,269,332)(H,270,330)(H,282,283)(H,284,285)(H,286,287)(H,288,289)(H,290,291)(H,292,293)(H,294,295)(H,296,297)(H,298,299)(H4,219,220,228)(H4,221,222,229)(H4,223,224,230)(H4,225,226,231)/t103-,104-,105-,106-,107-,108-,109?,114?,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128?,129?,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145+,161-,162-,163-,164-,165?,166-/m0/s1
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n/an/an/an/a 6.30n/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Activity of peptidic agonists on corticotropin releasing factor receptor receptor using agonist-stimulated adenylate cyclase assay

J Med Chem 43: 1641-60 (2000)


Article DOI: 10.1021/jm990590f
BindingDB Entry DOI: 10.7270/Q29S1RRP
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50362263
PNG
(CHEMBL1939574)
Show SMILES CCOc1ccc(c(CC)c1)-c1nn2c(C)cc(C(CC)CC)c2cc1C
Show InChI InChI=1S/C24H32N2O/c1-7-18(8-2)22-14-17(6)26-23(22)13-16(5)24(25-26)21-12-11-20(27-10-4)15-19(21)9-3/h11-15,18H,7-10H2,1-6H3
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n/an/an/an/a 6.90n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CRF1 receptor expressed in CHO-K1 cells assessed as CRF-stimulated cAMP accumulation by enzyme immunoassay

Bioorg Med Chem 20: 1122-38 (2012)


Article DOI: 10.1016/j.bmc.2011.11.015
BindingDB Entry DOI: 10.7270/Q2B27VQT
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50362272
PNG
(CHEMBL1939596)
Show SMILES COc1ccc(c(Cl)c1)-c1nn2c(C)cc(C(C)C)c2c(=O)n1C
Show InChI InChI=1S/C18H20ClN3O2/c1-10(2)14-8-11(3)22-16(14)18(23)21(4)17(20-22)13-7-6-12(24-5)9-15(13)19/h6-10H,1-5H3
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n/an/an/an/a 7.40n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CRF1 receptor expressed in CHO-K1 cells assessed as CRF-stimulated cAMP accumulation by enzyme immunoassay

Bioorg Med Chem 20: 1122-38 (2012)


Article DOI: 10.1016/j.bmc.2011.11.015
BindingDB Entry DOI: 10.7270/Q2B27VQT
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50354033
PNG
(CHEMBL1828887)
Show SMILES CCC(CC)Nc1c(C)c(Nc2ccc(OC)cc2Cl)nc2ccnn12
Show InChI InChI=1S/C19H24ClN5O/c1-5-13(6-2)22-19-12(3)18(24-17-9-10-21-25(17)19)23-16-8-7-14(26-4)11-15(16)20/h7-11,13,22H,5-6H2,1-4H3,(H,23,24)
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n/an/an/an/a 7.40n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CRF1 receptor expressed in CHO-K1 cells assessed as inhibition of CRF-induced cAMP accumulation after 15 mins by cAMP en...

Bioorg Med Chem 19: 5955-66 (2011)


Article DOI: 10.1016/j.bmc.2011.08.055
BindingDB Entry DOI: 10.7270/Q24X5862
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50351398
PNG
(CHEMBL1819088)
Show SMILES CCC(CC)Nc1c2CCOc2nc2c(c(C)nn12)-c1ccc(OC)cc1Cl
Show InChI InChI=1S/C21H25ClN4O2/c1-5-13(6-2)23-19-16-9-10-28-21(16)24-20-18(12(3)25-26(19)20)15-8-7-14(27-4)11-17(15)22/h7-8,11,13,23H,5-6,9-10H2,1-4H3
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n/an/an/an/a 8n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human corticotropin-releasing factor receptor 1 expressed in CHO-K1 cells assessed as inhibition of CRF-induced cAMP productio...

Bioorg Med Chem 19: 5432-45 (2011)


Article DOI: 10.1016/j.bmc.2011.07.055
BindingDB Entry DOI: 10.7270/Q2Z038JX
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50354036
PNG
(CHEMBL1828890)
Show SMILES CCCN(CCC)c1c(CC)c(Nc2ccc(OC)cc2Cl)nc2ccnn12
Show InChI InChI=1S/C21H28ClN5O/c1-5-12-26(13-6-2)21-16(7-3)20(25-19-10-11-23-27(19)21)24-18-9-8-15(28-4)14-17(18)22/h8-11,14H,5-7,12-13H2,1-4H3,(H,24,25)
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n/an/an/an/a 8.60n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CRF1 receptor expressed in CHO-K1 cells assessed as inhibition of CRF-induced cAMP accumulation after 15 mins by cAMP en...

Bioorg Med Chem 19: 5955-66 (2011)


Article DOI: 10.1016/j.bmc.2011.08.055
BindingDB Entry DOI: 10.7270/Q24X5862
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50354021
PNG
(CHEMBL1830517)
Show SMILES CCCN(CCC)c1c(C)c(Nc2ccc(OC)cc2Cl)nc2ncnn12
Show InChI InChI=1S/C19H25ClN6O/c1-5-9-25(10-6-2)18-13(3)17(24-19-21-12-22-26(18)19)23-16-8-7-14(27-4)11-15(16)20/h7-8,11-12H,5-6,9-10H2,1-4H3,(H,21,22,23,24)
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n/an/an/an/a 9n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CRF1 receptor expressed in CHO-K1 cells assessed as inhibition of CRF-induced cAMP accumulation after 15 mins by cAMP en...

Bioorg Med Chem 19: 5955-66 (2011)


Article DOI: 10.1016/j.bmc.2011.08.055
BindingDB Entry DOI: 10.7270/Q24X5862
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50369801
PNG
(CHEMBL1790241)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]1CCCN1C(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)CO)[C@@H](C)CC)C(C)O)C(C)C)[C@@H](C)O)C(=O)N[C@@H](C)C(N)=O
Show InChI InChI=1S/C205H339N59O63S/c1-30-104(21)159(198(322)225-106(23)163(214)287)259-193(317)142(87-157(285)286)253-184(308)132(77-99(11)12)246-182(306)130(75-97(7)8)244-172(296)117(46-36-38-67-207)231-170(294)118(47-39-68-221-204(215)216)233-189(313)139(84-151(213)274)251-194(318)143(91-266)256-188(312)137(82-113-88-219-93-223-113)241-165(289)108(25)227-169(293)120(51-58-147(209)270)234-173(297)121(52-59-148(210)271)229-164(288)107(24)228-179(303)128(73-95(3)4)243-176(300)123(54-61-150(212)273)236-190(314)140(85-155(281)282)242-166(290)109(26)226-168(292)116(45-35-37-66-206)239-200(324)161(110(27)268)261-178(302)126(65-72-328-29)238-174(298)124(55-62-152(275)276)237-181(305)134(79-101(15)16)254-197(321)158(103(19)20)258-177(301)125(56-63-153(277)278)235-171(295)119(48-40-69-222-205(217)218)232-180(304)129(74-96(5)6)245-183(307)131(76-98(9)10)247-187(311)138(83-114-89-220-94-224-114)250-186(310)136(81-112-43-33-32-34-44-112)255-201(325)162(111(28)269)262-192(316)135(80-102(17)18)248-191(315)141(86-156(283)284)252-185(309)133(78-100(13)14)249-195(319)144(92-267)257-199(323)160(105(22)31-2)260-196(320)145-49-41-70-263(145)203(327)146-50-42-71-264(146)202(326)127(57-64-154(279)280)240-175(299)122(53-60-149(211)272)230-167(291)115(208)90-265/h32-34,43-44,88-89,93-111,115-146,158-162,265-269H,30-31,35-42,45-87,90-92,206-208H2,1-29H3,(H2,209,270)(H2,210,271)(H2,211,272)(H2,212,273)(H2,213,274)(H2,214,287)(H,219,223)(H,220,224)(H,225,322)(H,226,292)(H,227,293)(H,228,303)(H,229,288)(H,230,291)(H,231,294)(H,232,304)(H,233,313)(H,234,297)(H,235,295)(H,236,314)(H,237,305)(H,238,298)(H,239,324)(H,240,299)(H,241,289)(H,242,290)(H,243,300)(H,244,296)(H,245,307)(H,246,306)(H,247,311)(H,248,315)(H,249,319)(H,250,310)(H,251,318)(H,252,309)(H,253,308)(H,254,321)(H,255,325)(H,256,312)(H,257,323)(H,258,301)(H,259,317)(H,260,320)(H,261,302)(H,262,316)(H,275,276)(H,277,278)(H,279,280)(H,281,282)(H,283,284)(H,285,286)(H4,215,216,221)(H4,217,218,222)/t104-,105-,106-,107-,108-,109+,110+,111?,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127+,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146+,158-,159-,160-,161+,162-/m0/s1
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n/an/an/an/a 9.70n/an/an/an/a



DuPont Pharmaceuticals Company

Curated by ChEMBL


Assay Description
Activity of peptidic agonists on corticotropin releasing factor receptor receptor using agonist-stimulated adenylate cyclase assay

J Med Chem 43: 1641-60 (2000)


Article DOI: 10.1021/jm990590f
BindingDB Entry DOI: 10.7270/Q29S1RRP
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50362266
PNG
(CHEMBL1939577)
Show SMILES CCC(CC)c1cc(C)n2nc(c(C)cc12)-c1cnc(cc1C)N(C)C
Show InChI InChI=1S/C22H30N4/c1-8-17(9-2)18-12-16(5)26-20(18)10-15(4)22(24-26)19-13-23-21(25(6)7)11-14(19)3/h10-13,17H,8-9H2,1-7H3
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n/an/an/an/a 11.5n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CRF1 receptor expressed in CHO-K1 cells assessed as CRF-stimulated cAMP accumulation by enzyme immunoassay

Bioorg Med Chem 20: 1122-38 (2012)


Article DOI: 10.1016/j.bmc.2011.11.015
BindingDB Entry DOI: 10.7270/Q2B27VQT
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50362292
PNG
(CHEMBL1939591)
Show SMILES CCC(CC)c1cc(C)n2nc(-c3cnc(OC)cc3C)n(C)c(=O)c12
Show InChI InChI=1S/C20H26N4O2/c1-7-14(8-2)15-10-13(4)24-18(15)20(25)23(5)19(22-24)16-11-21-17(26-6)9-12(16)3/h9-11,14H,7-8H2,1-6H3
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n/an/an/an/a 17.2n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CRF1 receptor expressed in CHO-K1 cells assessed as CRF-stimulated cAMP accumulation by enzyme immunoassay

Bioorg Med Chem 20: 1122-38 (2012)


Article DOI: 10.1016/j.bmc.2011.11.015
BindingDB Entry DOI: 10.7270/Q2B27VQT
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50354012
PNG
(CHEMBL1828897)
Show SMILES CCCN(CCC)c1cc(nc2ccnn12)N(CC)c1ccc(OC)cc1Cl
Show InChI InChI=1S/C21H28ClN5O/c1-5-12-25(13-6-2)21-15-20(24-19-10-11-23-27(19)21)26(7-3)18-9-8-16(28-4)14-17(18)22/h8-11,14-15H,5-7,12-13H2,1-4H3
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n/an/an/an/a 18.6n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CRF1 receptor expressed in CHO-K1 cells assessed as inhibition of CRF-induced cAMP accumulation after 15 mins by cAMP en...

Bioorg Med Chem 19: 5955-66 (2011)


Article DOI: 10.1016/j.bmc.2011.08.055
BindingDB Entry DOI: 10.7270/Q24X5862
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50354026
PNG
(CHEMBL1830522)
Show SMILES CCCN(CCC)c1nc(nc2ccnn12)N(C)c1ccc(OC)cc1Cl
Show InChI InChI=1S/C19H25ClN6O/c1-5-11-25(12-6-2)19-23-18(22-17-9-10-21-26(17)19)24(3)16-8-7-14(27-4)13-15(16)20/h7-10,13H,5-6,11-12H2,1-4H3
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n/an/an/an/a 26n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CRF1 receptor expressed in CHO-K1 cells assessed as inhibition of CRF-induced cAMP accumulation after 15 mins by cAMP en...

Bioorg Med Chem 19: 5955-66 (2011)


Article DOI: 10.1016/j.bmc.2011.08.055
BindingDB Entry DOI: 10.7270/Q24X5862
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))		BDBM50354015
PNG
(CHEMBL1828900)
Show SMILES CCCN(CCC)c1cc(nc2ccnn12)N(CC=C)c1ccc(OC)cc1Cl
Show InChI InChI=1S/C22H28ClN5O/c1-5-12-26(13-6-2)22-16-21(25-20-10-11-24-28(20)22)27(14-7-3)19-9-8-17(29-4)15-18(19)23/h7-11,15-16H,3,5-6,12-14H2,1-2,4H3
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n/an/an/an/a 28.9n/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity at human CRF1 receptor expressed in CHO-K1 cells assessed as inhibition of CRF-induced cAMP accumulation after 15 mins by cAMP en...

Bioorg Med Chem 19: 5955-66 (2011)


Article DOI: 10.1016/j.bmc.2011.08.055
BindingDB Entry DOI: 10.7270/Q24X5862
More data for this
Ligand-Target Pair
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