Compile Data Set for Download or QSAR

Found 83 hits of ec50 for UniProtKB: A0A024QZU0   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-interacting protein 1 (RIPK1) (Homo sapiens (Human))	BDBM50229700 (CHEMBL4085167) Show SMILES CCC(C)(C)C(=O)N(C)Cc1cc(F)cc(F)c1F Show InChI InChI=1S/C14H18F3NO/c1-5-14(2,3)13(19)18(4)8-9-6-10(15)7-11(16)12(9)17/h6-7H,5,8H2,1-4H3	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	CHEMBL MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	12	n/a	n/a	n/a	n/a
National Institute of Biological Sciences Curated by ChEMBL					Assay Description Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...				J Med Chem 60: 972-986 (2017) Article DOI: 10.1021/acs.jmedchem.6b01196 BindingDB Entry DOI: 10.7270/Q2QC05QD
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50492961 (CHEMBL2414924) Show SMILES COc1cc2[nH]c-3c(CCc4c[nH]nc-34)c2cc1C#N Show InChI InChI=1S/C15H12N4O/c1-20-13-5-12-11(4-9(13)6-16)10-3-2-8-7-17-19-14(8)15(10)18-12/h4-5,7,18H,2-3H2,1H3,(H,17,19)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	14	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of RIP1/JNK2 (unknown origin)-mediated necrosis				Bioorg Med Chem Lett 23: 4903-6 (2013) Article DOI: 10.1016/j.bmcl.2013.06.073 BindingDB Entry DOI: 10.7270/Q2GB2702
					More data for this Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1) (Homo sapiens (Human))	BDBM36372 ((5R)-5-[(7-chloro-1H-indol-3-yl)methyl]-3-methyl-2...) Show SMILES CN1C(=O)N[C@H](Cc2c[nH]c3c(Cl)cccc23)C1=O Show InChI InChI=1S/C13H12ClN3O2/c1-17-12(18)10(16-13(17)19)5-7-6-15-11-8(7)3-2-4-9(11)14/h2-4,6,10,15H,5H2,1H3,(H,16,19)/t10-/m1/s1	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	Purchase MMDB PC cid PC sid PDB UniChem Patents	PDB Article PubMed	n/a	n/a	n/a	n/a	18	n/a	n/a	7.3	30
Tufts University					Assay Description In vitro kinase assay using RIP1				Nat Chem Biol 4: 313-21 (2008) Article DOI: 10.1038/nchembio.83 BindingDB Entry DOI: 10.7270/Q21V5C91
					More data for this Ligand-Target Pair				3D Structure (crystal)
Receptor-interacting protein 1 (RIPK1) (Homo sapiens (Human))	BDBM50229025 (CHEMBL4092421) Show SMILES CCC(C)(C)C(=O)N(O)Cc1ccccc1 Show InChI InChI=1S/C13H19NO2/c1-4-13(2,3)12(15)14(16)10-11-8-6-5-7-9-11/h5-9,16H,4,10H2,1-3H3	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	28	n/a	n/a	n/a	n/a
National Institute of Biological Sciences Curated by ChEMBL					Assay Description Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...				J Med Chem 60: 972-986 (2017) Article DOI: 10.1021/acs.jmedchem.6b01196 BindingDB Entry DOI: 10.7270/Q2QC05QD
					More data for this Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1) (Homo sapiens (Human))	BDBM50229585 (CHEMBL4076443) Show SMILES CCC(C)(C)C(=O)N(C)Cc1cc(F)ccc1F Show InChI InChI=1S/C14H19F2NO/c1-5-14(2,3)13(18)17(4)9-10-8-11(15)6-7-12(10)16/h6-8H,5,9H2,1-4H3	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	36	n/a	n/a	n/a	n/a
National Institute of Biological Sciences Curated by ChEMBL					Assay Description Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...				J Med Chem 60: 972-986 (2017) Article DOI: 10.1021/acs.jmedchem.6b01196 BindingDB Entry DOI: 10.7270/Q2QC05QD
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50492955 (CHEMBL2414923) Show SMILES COc1cc2[nH]c-3c(CCc4c[nH]nc-34)c2cc1OC Show InChI InChI=1S/C15H15N3O2/c1-19-12-5-10-9-4-3-8-7-16-18-14(8)15(9)17-11(10)6-13(12)20-2/h5-7,17H,3-4H2,1-2H3,(H,16,18)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	47	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of RIP1/JNK2 (unknown origin)-mediated necrosis				Bioorg Med Chem Lett 23: 4903-6 (2013) Article DOI: 10.1016/j.bmcl.2013.06.073 BindingDB Entry DOI: 10.7270/Q2GB2702
					More data for this Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1) (Homo sapiens (Human))	BDBM50228870 (CHEMBL4083065) Show SMILES CCC(C)(C)C(=O)N(O)Cc1cc(F)c(F)c(F)c1 Show InChI InChI=1S/C13H16F3NO2/c1-4-13(2,3)12(18)17(19)7-8-5-9(14)11(16)10(15)6-8/h5-6,19H,4,7H2,1-3H3	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	49	n/a	n/a	n/a	n/a
National Institute of Biological Sciences Curated by ChEMBL					Assay Description Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...				J Med Chem 60: 972-986 (2017) Article DOI: 10.1021/acs.jmedchem.6b01196 BindingDB Entry DOI: 10.7270/Q2QC05QD
					More data for this Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1) (Homo sapiens (Human))	BDBM50229606 (CHEMBL4072591) Show SMILES CCC(C)(C)C(=O)N(O)Cc1ccc(F)c(F)c1 Show InChI InChI=1S/C13H17F2NO2/c1-4-13(2,3)12(17)16(18)8-9-5-6-10(14)11(15)7-9/h5-7,18H,4,8H2,1-3H3	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	56	n/a	n/a	n/a	n/a
National Institute of Biological Sciences Curated by ChEMBL					Assay Description Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...				J Med Chem 60: 972-986 (2017) Article DOI: 10.1021/acs.jmedchem.6b01196 BindingDB Entry DOI: 10.7270/Q2QC05QD
					More data for this Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1) (Homo sapiens (Human))	BDBM50229702 (CHEMBL4101314) Show SMILES CCC(C)(C)C(=O)N(C)Cc1cccc(F)c1F Show InChI InChI=1S/C14H19F2NO/c1-5-14(2,3)13(18)17(4)9-10-7-6-8-11(15)12(10)16/h6-8H,5,9H2,1-4H3	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	58	n/a	n/a	n/a	n/a
National Institute of Biological Sciences Curated by ChEMBL					Assay Description Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...				J Med Chem 60: 972-986 (2017) Article DOI: 10.1021/acs.jmedchem.6b01196 BindingDB Entry DOI: 10.7270/Q2QC05QD
					More data for this Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1) (Homo sapiens (Human))	BDBM50228873 (CHEMBL4063996) Show SMILES CCC(C)(C)C(=O)N(O)Cc1ccc(F)cc1 Show InChI InChI=1S/C13H18FNO2/c1-4-13(2,3)12(16)15(17)9-10-5-7-11(14)8-6-10/h5-8,17H,4,9H2,1-3H3	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	64	n/a	n/a	n/a	n/a
National Institute of Biological Sciences Curated by ChEMBL					Assay Description Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...				J Med Chem 60: 972-986 (2017) Article DOI: 10.1021/acs.jmedchem.6b01196 BindingDB Entry DOI: 10.7270/Q2QC05QD
					More data for this Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1) (Homo sapiens (Human))	BDBM50229598 (CHEMBL4096278) Show SMILES CCC(C)(C)C(=O)N(C)Cc1cccc(F)c1 Show InChI InChI=1S/C14H20FNO/c1-5-14(2,3)13(17)16(4)10-11-7-6-8-12(15)9-11/h6-9H,5,10H2,1-4H3	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	72	n/a	n/a	n/a	n/a
National Institute of Biological Sciences Curated by ChEMBL					Assay Description Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...				J Med Chem 60: 972-986 (2017) Article DOI: 10.1021/acs.jmedchem.6b01196 BindingDB Entry DOI: 10.7270/Q2QC05QD
					More data for this Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1) (Homo sapiens (Human))	BDBM50229605 (CHEMBL4061192) Show SMILES CCC(C)(C)C(=O)N(O)Cc1cc(F)cc(F)c1F Show InChI InChI=1S/C13H16F3NO2/c1-4-13(2,3)12(18)17(19)7-8-5-9(14)6-10(15)11(8)16/h5-6,19H,4,7H2,1-3H3	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	74	n/a	n/a	n/a	n/a
National Institute of Biological Sciences Curated by ChEMBL					Assay Description Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...				J Med Chem 60: 972-986 (2017) Article DOI: 10.1021/acs.jmedchem.6b01196 BindingDB Entry DOI: 10.7270/Q2QC05QD
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50492952 (CHEMBL2414918) Show SMILES N#Cc1ccc2[nH]c-3c(CCc4c[nH]nc-34)c2c1 Show InChI InChI=1S/C14H10N4/c15-6-8-1-4-12-11(5-8)10-3-2-9-7-16-18-13(9)14(10)17-12/h1,4-5,7,17H,2-3H2,(H,16,18)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	80	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of RIP1/JNK2 (unknown origin)-mediated necrosis				Bioorg Med Chem Lett 23: 4903-6 (2013) Article DOI: 10.1016/j.bmcl.2013.06.073 BindingDB Entry DOI: 10.7270/Q2GB2702
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM422045 (US10508102, Compound (Ia)) Show SMILES CN1C(=O)N[C@H](Cc2c[nH]c3c(Cl)c(F)ccc23)C1=O Show InChI	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	93.7	n/a	n/a	n/a	n/a
President and Fellows of Harvard College; Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences US Patent					Assay Description RIP1 kinase assays were performed using ADP-Glo assay (Promega) according to manufacturer's protocol. Reactions were performed in 50 mM HEPES, pH...				US Patent US10508102 (2019) BindingDB Entry DOI: 10.7270/Q28S4S93
					More data for this Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1) (Homo sapiens (Human))	BDBM50229512 (CHEMBL4083937) Show SMILES CN(Cc1cc(F)cc(F)c1F)C(=O)C(C)(C)C Show InChI InChI=1S/C13H16F3NO/c1-13(2,3)12(18)17(4)7-8-5-9(14)6-10(15)11(8)16/h5-6H,7H2,1-4H3	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	98	n/a	n/a	n/a	n/a
National Institute of Biological Sciences Curated by ChEMBL					Assay Description Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...				J Med Chem 60: 972-986 (2017) Article DOI: 10.1021/acs.jmedchem.6b01196 BindingDB Entry DOI: 10.7270/Q2QC05QD
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50492957 (CHEMBL2414921) Show SMILES COc1ccc2c3CCc4c[nH]nc4-c3[nH]c2c1 Show InChI InChI=1S/C14H13N3O/c1-18-9-3-5-10-11-4-2-8-7-15-17-13(8)14(11)16-12(10)6-9/h3,5-7,16H,2,4H2,1H3,(H,15,17)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of RIP1/JNK2 (unknown origin)-mediated necrosis				Bioorg Med Chem Lett 23: 4903-6 (2013) Article DOI: 10.1016/j.bmcl.2013.06.073 BindingDB Entry DOI: 10.7270/Q2GB2702
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50492944 (CHEMBL2414925) Show SMILES COc1cc(OC)c2c3CCc4c[nH]nc4-c3[nH]c2c1 Show InChI InChI=1S/C15H15N3O2/c1-19-9-5-11-13(12(6-9)20-2)10-4-3-8-7-16-18-14(8)15(10)17-11/h5-7,17H,3-4H2,1-2H3,(H,16,18)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	110	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of RIP1/JNK2 (unknown origin)-mediated necrosis				Bioorg Med Chem Lett 23: 4903-6 (2013) Article DOI: 10.1016/j.bmcl.2013.06.073 BindingDB Entry DOI: 10.7270/Q2GB2702
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50492945 (CHEMBL2414922) Show SMILES N#Cc1ccc2c3CCc4c[nH]nc4-c3[nH]c2c1 Show InChI InChI=1S/C14H10N4/c15-6-8-1-3-10-11-4-2-9-7-16-18-13(9)14(11)17-12(10)5-8/h1,3,5,7,17H,2,4H2,(H,16,18)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	110	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of RIP1/JNK2 (unknown origin)-mediated necrosis				Bioorg Med Chem Lett 23: 4903-6 (2013) Article DOI: 10.1016/j.bmcl.2013.06.073 BindingDB Entry DOI: 10.7270/Q2GB2702
					More data for this Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1) (Homo sapiens (Human))	BDBM50229699 (CHEMBL4059584) Show SMILES CCC(C)(C)C(=O)N(C)Cc1ccccc1F Show InChI InChI=1S/C14H20FNO/c1-5-14(2,3)13(17)16(4)10-11-8-6-7-9-12(11)15/h6-9H,5,10H2,1-4H3	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	125	n/a	n/a	n/a	n/a
National Institute of Biological Sciences Curated by ChEMBL					Assay Description Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...				J Med Chem 60: 972-986 (2017) Article DOI: 10.1021/acs.jmedchem.6b01196 BindingDB Entry DOI: 10.7270/Q2QC05QD
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50492948 (CHEMBL2414915) Show SMILES Fc1ccc2[nH]c-3c(CCc4c[nH]nc-34)c2c1 Show InChI InChI=1S/C13H10FN3/c14-8-2-4-11-10(5-8)9-3-1-7-6-15-17-12(7)13(9)16-11/h2,4-6,16H,1,3H2,(H,15,17)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	140	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of RIP1/JNK2 (unknown origin)-mediated necrosis				Bioorg Med Chem Lett 23: 4903-6 (2013) Article DOI: 10.1016/j.bmcl.2013.06.073 BindingDB Entry DOI: 10.7270/Q2GB2702
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50492956 (CHEMBL2414926) Show SMILES C1Oc2cc3[nH]c-4c(CCc5c[nH]nc-45)c3cc2O1 Show InChI InChI=1S/C14H11N3O2/c1-2-8-9-3-11-12(19-6-18-11)4-10(9)16-14(8)13-7(1)5-15-17-13/h3-5,16H,1-2,6H2,(H,15,17)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	150	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of RIP1/JNK2 (unknown origin)-mediated necrosis				Bioorg Med Chem Lett 23: 4903-6 (2013) Article DOI: 10.1016/j.bmcl.2013.06.073 BindingDB Entry DOI: 10.7270/Q2GB2702
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50492964 (CHEMBL2414917) Show SMILES COc1ccc2[nH]c-3c(CCc4c[nH]nc-34)c2c1 Show InChI InChI=1S/C14H13N3O/c1-18-9-3-5-12-11(6-9)10-4-2-8-7-15-17-13(8)14(10)16-12/h3,5-7,16H,2,4H2,1H3,(H,15,17)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	170	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of RIP1/JNK2 (unknown origin)-mediated necrosis				Bioorg Med Chem Lett 23: 4903-6 (2013) Article DOI: 10.1016/j.bmcl.2013.06.073 BindingDB Entry DOI: 10.7270/Q2GB2702
					More data for this Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1) (Homo sapiens (Human))	BDBM36371 (5-(1H-indol-3-ylmethyl)-3-methyl-2-thioxo-4-Imidaz...) Show SMILES CN1C(=S)NC(Cc2c[nH]c3ccccc23)C1=O Show InChI InChI=1S/C13H13N3OS/c1-16-12(17)11(15-13(16)18)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,11,14H,6H2,1H3,(H,15,18)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	Purchase PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	n/a	n/a	182	n/a	n/a	7.3	30
Tufts University					Assay Description In vitro kinase assay using RIP1				Nat Chem Biol 4: 313-21 (2008) Article DOI: 10.1038/nchembio.83 BindingDB Entry DOI: 10.7270/Q21V5C91
					More data for this Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1) (Homo sapiens (Human))	BDBM50228872 (CHEMBL4091760) Show SMILES CCC(C)(C)C(=O)N(O)Cc1ccc(F)cc1F Show InChI InChI=1S/C13H17F2NO2/c1-4-13(2,3)12(17)16(18)8-9-5-6-10(14)7-11(9)15/h5-7,18H,4,8H2,1-3H3	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	198	n/a	n/a	n/a	n/a
National Institute of Biological Sciences Curated by ChEMBL					Assay Description Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...				J Med Chem 60: 972-986 (2017) Article DOI: 10.1021/acs.jmedchem.6b01196 BindingDB Entry DOI: 10.7270/Q2QC05QD
					More data for this Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1) (Homo sapiens (Human))	BDBM50229541 (CHEMBL4096270) Show SMILES CCC(C)(C)C(=O)N(C)Cc1cccs1 Show InChI InChI=1S/C12H19NOS/c1-5-12(2,3)11(14)13(4)9-10-7-6-8-15-10/h6-8H,5,9H2,1-4H3	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	221	n/a	n/a	n/a	n/a
National Institute of Biological Sciences Curated by ChEMBL					Assay Description Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...				J Med Chem 60: 972-986 (2017) Article DOI: 10.1021/acs.jmedchem.6b01196 BindingDB Entry DOI: 10.7270/Q2QC05QD
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50492946 (CHEMBL2414920) Show SMILES FC(F)(F)c1ccc2c3CCc4c[nH]nc4-c3[nH]c2c1 Show InChI InChI=1S/C14H10F3N3/c15-14(16,17)8-2-4-9-10-3-1-7-6-18-20-12(7)13(10)19-11(9)5-8/h2,4-6,19H,1,3H2,(H,18,20)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	250	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of RIP1/JNK2 (unknown origin)-mediated necrosis				Bioorg Med Chem Lett 23: 4903-6 (2013) Article DOI: 10.1016/j.bmcl.2013.06.073 BindingDB Entry DOI: 10.7270/Q2GB2702
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50492947 (CHEMBL2414919) Show SMILES Clc1ccc2c3CCc4c[nH]nc4-c3[nH]c2c1 Show InChI InChI=1S/C13H10ClN3/c14-8-2-4-9-10-3-1-7-6-15-17-12(7)13(10)16-11(9)5-8/h2,4-6,16H,1,3H2,(H,15,17)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	250	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of RIP1/JNK2 (unknown origin)-mediated necrosis				Bioorg Med Chem Lett 23: 4903-6 (2013) Article DOI: 10.1016/j.bmcl.2013.06.073 BindingDB Entry DOI: 10.7270/Q2GB2702
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM422046 (US10508102, Compound A) Show SMILES Fc1ccc2cc[nH]c2c1Cl Show InChI InChI=1S/C8H5ClFN/c9-7-6(10)2-1-5-3-4-11-8(5)7/h1-4,11H	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	256	n/a	n/a	n/a	n/a
President and Fellows of Harvard College; Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences US Patent					Assay Description RIP1 kinase assays were performed using ADP-Glo assay (Promega) according to manufacturer's protocol. Reactions were performed in 50 mM HEPES, pH...				US Patent US10508102 (2019) BindingDB Entry DOI: 10.7270/Q28S4S93
					More data for this Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1) (Homo sapiens (Human))	BDBM50228871 (CHEMBL4099502) Show SMILES CCC(C)(C)C(=O)N(O)Cc1ccc(F)c(F)c1F Show InChI InChI=1S/C13H16F3NO2/c1-4-13(2,3)12(18)17(19)7-8-5-6-9(14)11(16)10(8)15/h5-6,19H,4,7H2,1-3H3	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	CHEMBL MMDB PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	262	n/a	n/a	n/a	n/a
National Institute of Biological Sciences Curated by ChEMBL					Assay Description Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...				J Med Chem 60: 972-986 (2017) Article DOI: 10.1021/acs.jmedchem.6b01196 BindingDB Entry DOI: 10.7270/Q2QC05QD
					More data for this Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1) (Homo sapiens (Human))	BDBM50229517 (CHEMBL4068805) Show SMILES CCC(C)(C)C(=O)N(C)Cc1ccc(C)s1 Show InChI InChI=1S/C13H21NOS/c1-6-13(3,4)12(15)14(5)9-11-8-7-10(2)16-11/h7-8H,6,9H2,1-5H3	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	378	n/a	n/a	n/a	n/a
National Institute of Biological Sciences Curated by ChEMBL					Assay Description Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...				J Med Chem 60: 972-986 (2017) Article DOI: 10.1021/acs.jmedchem.6b01196 BindingDB Entry DOI: 10.7270/Q2QC05QD
					More data for this Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1) (Homo sapiens (Human))	BDBM50229601 (CHEMBL4082828) Show SMILES CCC(C)(C)C(=O)N(C)Cc1ccccc1 Show InChI InChI=1S/C14H21NO/c1-5-14(2,3)13(16)15(4)11-12-9-7-6-8-10-12/h6-10H,5,11H2,1-4H3	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	457	n/a	n/a	n/a	n/a
National Institute of Biological Sciences Curated by ChEMBL					Assay Description Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...				J Med Chem 60: 972-986 (2017) Article DOI: 10.1021/acs.jmedchem.6b01196 BindingDB Entry DOI: 10.7270/Q2QC05QD
					More data for this Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1) (Homo sapiens (Human))	BDBM50229242 (CHEMBL4084908) Show SMILES CN(Cc1cc(F)cc(F)c1F)C(=O)C1(C)CCCCC1 Show InChI InChI=1S/C16H20F3NO/c1-16(6-4-3-5-7-16)15(21)20(2)10-11-8-12(17)9-13(18)14(11)19/h8-9H,3-7,10H2,1-2H3	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	490	n/a	n/a	n/a	n/a
National Institute of Biological Sciences Curated by ChEMBL					Assay Description Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...				J Med Chem 60: 972-986 (2017) Article DOI: 10.1021/acs.jmedchem.6b01196 BindingDB Entry DOI: 10.7270/Q2QC05QD
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM24713 (1,2,4,5-tetrahydropyrazolo[3,4-a]carbazole | 3,4,1...) Show SMILES C1Cc2c([nH]c3ccccc23)-c2n[nH]cc12 Show InChI InChI=1S/C13H11N3/c1-2-4-11-9(3-1)10-6-5-8-7-14-16-12(8)13(10)15-11/h1-4,7,15H,5-6H2,(H,14,16)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar	Purchase PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	500	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of RIP1/JNK2 (unknown origin)-mediated necrosis				Bioorg Med Chem Lett 23: 4903-6 (2013) Article DOI: 10.1016/j.bmcl.2013.06.073 BindingDB Entry DOI: 10.7270/Q2GB2702
					More data for this Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1) (Homo sapiens (Human))	BDBM50229586 (CHEMBL4087013) Show SMILES CCC(C)(C)C(=O)N(C)Cc1ccc(F)cc1F Show InChI InChI=1S/C14H19F2NO/c1-5-14(2,3)13(18)17(4)9-10-6-7-11(15)8-12(10)16/h6-8H,5,9H2,1-4H3	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	627	n/a	n/a	n/a	n/a
National Institute of Biological Sciences Curated by ChEMBL					Assay Description Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...				J Med Chem 60: 972-986 (2017) Article DOI: 10.1021/acs.jmedchem.6b01196 BindingDB Entry DOI: 10.7270/Q2QC05QD
					More data for this Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1) (Homo sapiens (Human))	BDBM50229701 (CHEMBL4078224) Show SMILES CCC(C)(C)C(=O)N(C)Cc1cccc(Cl)c1 Show InChI InChI=1S/C14H20ClNO/c1-5-14(2,3)13(17)16(4)10-11-7-6-8-12(15)9-11/h6-9H,5,10H2,1-4H3	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	628	n/a	n/a	n/a	n/a
National Institute of Biological Sciences Curated by ChEMBL					Assay Description Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...				J Med Chem 60: 972-986 (2017) Article DOI: 10.1021/acs.jmedchem.6b01196 BindingDB Entry DOI: 10.7270/Q2QC05QD
					More data for this Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1) (Homo sapiens (Human))	BDBM50229515 (CHEMBL4076266) Show SMILES CCC(C)(C)C(=O)N(C)Cc1ccco1 Show InChI InChI=1S/C12H19NO2/c1-5-12(2,3)11(14)13(4)9-10-7-6-8-15-10/h6-8H,5,9H2,1-4H3	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	628	n/a	n/a	n/a	n/a
National Institute of Biological Sciences Curated by ChEMBL					Assay Description Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...				J Med Chem 60: 972-986 (2017) Article DOI: 10.1021/acs.jmedchem.6b01196 BindingDB Entry DOI: 10.7270/Q2QC05QD
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50389604 (CHEMBL1929485) Show SMILES C1Cc2c[nH]nc2-c2[nH]c3ccccc3c2C1 Show InChI InChI=1S/C14H13N3/c1-2-7-12-10(5-1)11-6-3-4-9-8-15-17-13(9)14(11)16-12/h1-2,5,7-8,16H,3-4,6H2,(H,15,17)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar	CHEMBL MMDB PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	640	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of RIP1/JNK2 (unknown origin)-mediated necrosis				Bioorg Med Chem Lett 23: 4903-6 (2013) Article DOI: 10.1016/j.bmcl.2013.06.073 BindingDB Entry DOI: 10.7270/Q2GB2702
					More data for this Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1) (Homo sapiens (Human))	BDBM50229429 (CHEMBL4092663) Show SMILES CN(Cc1cc(F)cc(F)c1F)C(=O)C1(CCC1)C(F)(F)F Show InChI InChI=1S/C14H13F6NO/c1-21(7-8-5-9(15)6-10(16)11(8)17)12(22)13(3-2-4-13)14(18,19)20/h5-6H,2-4,7H2,1H3	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	656	n/a	n/a	n/a	n/a
National Institute of Biological Sciences Curated by ChEMBL					Assay Description Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...				J Med Chem 60: 972-986 (2017) Article DOI: 10.1021/acs.jmedchem.6b01196 BindingDB Entry DOI: 10.7270/Q2QC05QD
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50492958 (CHEMBL2414985) Show SMILES Clc1cccc2[nH]c-3c(CCc4c[nH]nc-34)c12 Show InChI InChI=1S/C13H10ClN3/c14-9-2-1-3-10-11(9)8-5-4-7-6-15-17-12(7)13(8)16-10/h1-3,6,16H,4-5H2,(H,15,17)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	670	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of RIP1/JNK2 (unknown origin)-mediated necrosis				Bioorg Med Chem Lett 23: 4903-6 (2013) Article DOI: 10.1016/j.bmcl.2013.06.073 BindingDB Entry DOI: 10.7270/Q2GB2702
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50492951 (CHEMBL2414983) Show SMILES Cc1cccc2c3CCc4c[nH]nc4-c3[nH]c12 Show InChI InChI=1S/C14H13N3/c1-8-3-2-4-10-11-6-5-9-7-15-17-13(9)14(11)16-12(8)10/h2-4,7,16H,5-6H2,1H3,(H,15,17)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	760	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of RIP1/JNK2 (unknown origin)-mediated necrosis				Bioorg Med Chem Lett 23: 4903-6 (2013) Article DOI: 10.1016/j.bmcl.2013.06.073 BindingDB Entry DOI: 10.7270/Q2GB2702
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50492963 (CHEMBL2414916) Show SMILES CCc1ccc2[nH]c-3c(CCc4c[nH]nc-34)c2c1 Show InChI InChI=1S/C15H15N3/c1-2-9-3-6-13-12(7-9)11-5-4-10-8-16-18-14(10)15(11)17-13/h3,6-8,17H,2,4-5H2,1H3,(H,16,18)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	780	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of RIP1/JNK2 (unknown origin)-mediated necrosis				Bioorg Med Chem Lett 23: 4903-6 (2013) Article DOI: 10.1016/j.bmcl.2013.06.073 BindingDB Entry DOI: 10.7270/Q2GB2702
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50492962 (CHEMBL2414981) Show SMILES CC1Cc2c([nH]c3ccccc23)-c2n[nH]cc12 Show InChI InChI=1S/C14H13N3/c1-8-6-10-9-4-2-3-5-12(9)16-13(10)14-11(8)7-15-17-14/h2-5,7-8,16H,6H2,1H3,(H,15,17)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	810	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of RIP1/JNK2 (unknown origin)-mediated necrosis				Bioorg Med Chem Lett 23: 4903-6 (2013) Article DOI: 10.1016/j.bmcl.2013.06.073 BindingDB Entry DOI: 10.7270/Q2GB2702
					More data for this Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1) (Homo sapiens (Human))	BDBM50229587 (CHEMBL4080685) Show SMILES CCC(C)(C)C(=O)N(C)Cc1ccc(F)cc1 Show InChI InChI=1S/C14H20FNO/c1-5-14(2,3)13(17)16(4)10-11-6-8-12(15)9-7-11/h6-9H,5,10H2,1-4H3	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	815	n/a	n/a	n/a	n/a
National Institute of Biological Sciences Curated by ChEMBL					Assay Description Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...				J Med Chem 60: 972-986 (2017) Article DOI: 10.1021/acs.jmedchem.6b01196 BindingDB Entry DOI: 10.7270/Q2QC05QD
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1 (Homo sapiens (Human))	BDBM50492959 (CHEMBL2414982) Show SMILES Fc1cccc2c3CCc4c[nH]nc4-c3[nH]c12 Show InChI InChI=1S/C13H10FN3/c14-10-3-1-2-8-9-5-4-7-6-15-17-11(7)13(9)16-12(8)10/h1-3,6,16H,4-5H2,(H,15,17)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	860	n/a	n/a	n/a	n/a
Chinese Academy of Sciences Curated by ChEMBL					Assay Description Inhibition of RIP1/JNK2 (unknown origin)-mediated necrosis				Bioorg Med Chem Lett 23: 4903-6 (2013) Article DOI: 10.1016/j.bmcl.2013.06.073 BindingDB Entry DOI: 10.7270/Q2GB2702
					More data for this Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1) (Homo sapiens (Human))	BDBM50229603 (CHEMBL4090332) Show SMILES CCC(C)(C)C(=O)NCc1ccccc1F Show InChI InChI=1S/C13H18FNO/c1-4-13(2,3)12(16)15-9-10-7-5-6-8-11(10)14/h5-8H,4,9H2,1-3H3,(H,15,16)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	898	n/a	n/a	n/a	n/a
National Institute of Biological Sciences Curated by ChEMBL					Assay Description Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...				J Med Chem 60: 972-986 (2017) Article DOI: 10.1021/acs.jmedchem.6b01196 BindingDB Entry DOI: 10.7270/Q2QC05QD
					More data for this Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1) (Homo sapiens (Human))	BDBM50229028 (CHEMBL4066793) Show SMILES CCC(C)(C)C(=O)NC(CO)c1ccccc1 Show InChI InChI=1S/C14H21NO2/c1-4-14(2,3)13(17)15-12(10-16)11-8-6-5-7-9-11/h5-9,12,16H,4,10H2,1-3H3,(H,15,17)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.08E+3	n/a	n/a	n/a	n/a
National Institute of Biological Sciences Curated by ChEMBL					Assay Description Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...				J Med Chem 60: 972-986 (2017) Article DOI: 10.1021/acs.jmedchem.6b01196 BindingDB Entry DOI: 10.7270/Q2QC05QD
					More data for this Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1) (Homo sapiens (Human))	BDBM50229597 (CHEMBL4104038) Show SMILES CCC(C)(C)C(=O)N(C)Cc1cccc(Br)c1 Show InChI InChI=1S/C14H20BrNO/c1-5-14(2,3)13(17)16(4)10-11-7-6-8-12(15)9-11/h6-9H,5,10H2,1-4H3	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.23E+3	n/a	n/a	n/a	n/a
National Institute of Biological Sciences Curated by ChEMBL					Assay Description Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...				J Med Chem 60: 972-986 (2017) Article DOI: 10.1021/acs.jmedchem.6b01196 BindingDB Entry DOI: 10.7270/Q2QC05QD
					More data for this Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1) (Homo sapiens (Human))	BDBM50229422 (CHEMBL4102856) Show SMILES CN(Cc1cc(F)cc(F)c1F)C(=O)C1(CCCC1)C(F)(F)F Show InChI InChI=1S/C15H15F6NO/c1-22(8-9-6-10(16)7-11(17)12(9)18)13(23)14(15(19,20)21)4-2-3-5-14/h6-7H,2-5,8H2,1H3	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.23E+3	n/a	n/a	n/a	n/a
National Institute of Biological Sciences Curated by ChEMBL					Assay Description Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...				J Med Chem 60: 972-986 (2017) Article DOI: 10.1021/acs.jmedchem.6b01196 BindingDB Entry DOI: 10.7270/Q2QC05QD
					More data for this Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1) (Homo sapiens (Human))	BDBM50229583 (CHEMBL4063537) Show SMILES CCC(C)(C)C(=O)N(C)Cc1c(F)cc(F)cc1F Show InChI InChI=1S/C14H18F3NO/c1-5-14(2,3)13(19)18(4)8-10-11(16)6-9(15)7-12(10)17/h6-7H,5,8H2,1-4H3	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.25E+3	n/a	n/a	n/a	n/a
National Institute of Biological Sciences Curated by ChEMBL					Assay Description Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...				J Med Chem 60: 972-986 (2017) Article DOI: 10.1021/acs.jmedchem.6b01196 BindingDB Entry DOI: 10.7270/Q2QC05QD
					More data for this Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1) (Homo sapiens (Human))	BDBM50229610 (CHEMBL4073983) Show SMILES CCC(C)(C)C(=O)N(C)Cc1cc(C)c(C)s1 Show InChI InChI=1S/C14H23NOS/c1-7-14(4,5)13(16)15(6)9-12-8-10(2)11(3)17-12/h8H,7,9H2,1-6H3	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.31E+3	n/a	n/a	n/a	n/a
National Institute of Biological Sciences Curated by ChEMBL					Assay Description Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...				J Med Chem 60: 972-986 (2017) Article DOI: 10.1021/acs.jmedchem.6b01196 BindingDB Entry DOI: 10.7270/Q2QC05QD
					More data for this Ligand-Target Pair

Displayed 1 to 50 (of 83 total )  |  Next  |  Last  >>

Jump to: