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Compile Data Set for Download or QSAR

Found 83 hits of ec50 for UniProtKB: A0A024QZU0   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM50229700
PNG
(CHEMBL4085167)
Show SMILES CCC(C)(C)C(=O)N(C)Cc1cc(F)cc(F)c1F
Show InChI InChI=1S/C14H18F3NO/c1-5-14(2,3)13(19)18(4)8-9-6-10(15)7-11(16)12(9)17/h6-7H,5,8H2,1-4H3
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n/an/an/an/a 12n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
BindingDB Entry DOI: 10.7270/Q2QC05QD
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50492961
PNG
(CHEMBL2414924)
Show SMILES COc1cc2[nH]c-3c(CCc4c[nH]nc-34)c2cc1C#N
Show InChI InChI=1S/C15H12N4O/c1-20-13-5-12-11(4-9(13)6-16)10-3-2-8-7-17-19-14(8)15(10)18-12/h4-5,7,18H,2-3H2,1H3,(H,17,19)
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n/an/an/an/a 14n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1/JNK2 (unknown origin)-mediated necrosis


Bioorg Med Chem Lett 23: 4903-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.073
BindingDB Entry DOI: 10.7270/Q2GB2702
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM36372
PNG
((5R)-5-[(7-chloro-1H-indol-3-yl)methyl]-3-methyl-2...)
Show SMILES CN1C(=O)N[C@H](Cc2c[nH]c3c(Cl)cccc23)C1=O
Show InChI InChI=1S/C13H12ClN3O2/c1-17-12(18)10(16-13(17)19)5-7-6-15-11-8(7)3-2-4-9(11)14/h2-4,6,10,15H,5H2,1H3,(H,16,19)/t10-/m1/s1
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n/an/an/an/a 18n/an/a7.330



Tufts University



Assay Description
In vitro kinase assay using RIP1


Nat Chem Biol 4: 313-21 (2008)


Article DOI: 10.1038/nchembio.83
BindingDB Entry DOI: 10.7270/Q21V5C91
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM50229025
PNG
(CHEMBL4092421)
Show SMILES CCC(C)(C)C(=O)N(O)Cc1ccccc1
Show InChI InChI=1S/C13H19NO2/c1-4-13(2,3)12(15)14(16)10-11-8-6-5-7-9-11/h5-9,16H,4,10H2,1-3H3
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n/an/an/an/a 28n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
BindingDB Entry DOI: 10.7270/Q2QC05QD
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM50229585
PNG
(CHEMBL4076443)
Show SMILES CCC(C)(C)C(=O)N(C)Cc1cc(F)ccc1F
Show InChI InChI=1S/C14H19F2NO/c1-5-14(2,3)13(18)17(4)9-10-8-11(15)6-7-12(10)16/h6-8H,5,9H2,1-4H3
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n/an/an/an/a 36n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
BindingDB Entry DOI: 10.7270/Q2QC05QD
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50492955
PNG
(CHEMBL2414923)
Show SMILES COc1cc2[nH]c-3c(CCc4c[nH]nc-34)c2cc1OC
Show InChI InChI=1S/C15H15N3O2/c1-19-12-5-10-9-4-3-8-7-16-18-14(8)15(9)17-11(10)6-13(12)20-2/h5-7,17H,3-4H2,1-2H3,(H,16,18)
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n/an/an/an/a 47n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1/JNK2 (unknown origin)-mediated necrosis


Bioorg Med Chem Lett 23: 4903-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.073
BindingDB Entry DOI: 10.7270/Q2GB2702
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM50228870
PNG
(CHEMBL4083065)
Show SMILES CCC(C)(C)C(=O)N(O)Cc1cc(F)c(F)c(F)c1
Show InChI InChI=1S/C13H16F3NO2/c1-4-13(2,3)12(18)17(19)7-8-5-9(14)11(16)10(15)6-8/h5-6,19H,4,7H2,1-3H3
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n/an/an/an/a 49n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
BindingDB Entry DOI: 10.7270/Q2QC05QD
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM50229606
PNG
(CHEMBL4072591)
Show SMILES CCC(C)(C)C(=O)N(O)Cc1ccc(F)c(F)c1
Show InChI InChI=1S/C13H17F2NO2/c1-4-13(2,3)12(17)16(18)8-9-5-6-10(14)11(15)7-9/h5-7,18H,4,8H2,1-3H3
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n/an/an/an/a 56n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
BindingDB Entry DOI: 10.7270/Q2QC05QD
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM50229702
PNG
(CHEMBL4101314)
Show SMILES CCC(C)(C)C(=O)N(C)Cc1cccc(F)c1F
Show InChI InChI=1S/C14H19F2NO/c1-5-14(2,3)13(18)17(4)9-10-7-6-8-11(15)12(10)16/h6-8H,5,9H2,1-4H3
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n/an/an/an/a 58n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
BindingDB Entry DOI: 10.7270/Q2QC05QD
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM50228873
PNG
(CHEMBL4063996)
Show SMILES CCC(C)(C)C(=O)N(O)Cc1ccc(F)cc1
Show InChI InChI=1S/C13H18FNO2/c1-4-13(2,3)12(16)15(17)9-10-5-7-11(14)8-6-10/h5-8,17H,4,9H2,1-3H3
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n/an/an/an/a 64n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
BindingDB Entry DOI: 10.7270/Q2QC05QD
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM50229598
PNG
(CHEMBL4096278)
Show SMILES CCC(C)(C)C(=O)N(C)Cc1cccc(F)c1
Show InChI InChI=1S/C14H20FNO/c1-5-14(2,3)13(17)16(4)10-11-7-6-8-12(15)9-11/h6-9H,5,10H2,1-4H3
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n/an/an/an/a 72n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
BindingDB Entry DOI: 10.7270/Q2QC05QD
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM50229605
PNG
(CHEMBL4061192)
Show SMILES CCC(C)(C)C(=O)N(O)Cc1cc(F)cc(F)c1F
Show InChI InChI=1S/C13H16F3NO2/c1-4-13(2,3)12(18)17(19)7-8-5-9(14)6-10(15)11(8)16/h5-6,19H,4,7H2,1-3H3
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n/an/an/an/a 74n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
BindingDB Entry DOI: 10.7270/Q2QC05QD
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50492952
PNG
(CHEMBL2414918)
Show SMILES N#Cc1ccc2[nH]c-3c(CCc4c[nH]nc-34)c2c1
Show InChI InChI=1S/C14H10N4/c15-6-8-1-4-12-11(5-8)10-3-2-9-7-16-18-13(9)14(10)17-12/h1,4-5,7,17H,2-3H2,(H,16,18)
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n/an/an/an/a 80n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1/JNK2 (unknown origin)-mediated necrosis


Bioorg Med Chem Lett 23: 4903-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.073
BindingDB Entry DOI: 10.7270/Q2GB2702
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM422045
PNG
(US10508102, Compound (Ia))
Show SMILES CN1C(=O)N[C@H](Cc2c[nH]c3c(Cl)c(F)ccc23)C1=O
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US Patent
n/an/an/an/a 93.7n/an/an/an/a



President and Fellows of Harvard College; Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences

US Patent


Assay Description
RIP1 kinase assays were performed using ADP-Glo assay (Promega) according to manufacturer's protocol. Reactions were performed in 50 mM HEPES, pH...


US Patent US10508102 (2019)


BindingDB Entry DOI: 10.7270/Q28S4S93
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM50229512
PNG
(CHEMBL4083937)
Show SMILES CN(Cc1cc(F)cc(F)c1F)C(=O)C(C)(C)C
Show InChI InChI=1S/C13H16F3NO/c1-13(2,3)12(18)17(4)7-8-5-9(14)6-10(15)11(8)16/h5-6H,7H2,1-4H3
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n/an/an/an/a 98n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
BindingDB Entry DOI: 10.7270/Q2QC05QD
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50492957
PNG
(CHEMBL2414921)
Show SMILES COc1ccc2c3CCc4c[nH]nc4-c3[nH]c2c1
Show InChI InChI=1S/C14H13N3O/c1-18-9-3-5-10-11-4-2-8-7-15-17-13(8)14(11)16-12(10)6-9/h3,5-7,16H,2,4H2,1H3,(H,15,17)
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n/an/an/an/a 100n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1/JNK2 (unknown origin)-mediated necrosis


Bioorg Med Chem Lett 23: 4903-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.073
BindingDB Entry DOI: 10.7270/Q2GB2702
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50492944
PNG
(CHEMBL2414925)
Show SMILES COc1cc(OC)c2c3CCc4c[nH]nc4-c3[nH]c2c1
Show InChI InChI=1S/C15H15N3O2/c1-19-9-5-11-13(12(6-9)20-2)10-4-3-8-7-16-18-14(8)15(10)17-11/h5-7,17H,3-4H2,1-2H3,(H,16,18)
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n/an/an/an/a 110n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1/JNK2 (unknown origin)-mediated necrosis


Bioorg Med Chem Lett 23: 4903-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.073
BindingDB Entry DOI: 10.7270/Q2GB2702
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50492945
PNG
(CHEMBL2414922)
Show SMILES N#Cc1ccc2c3CCc4c[nH]nc4-c3[nH]c2c1
Show InChI InChI=1S/C14H10N4/c15-6-8-1-3-10-11-4-2-9-7-16-18-13(9)14(11)17-12(10)5-8/h1,3,5,7,17H,2,4H2,(H,16,18)
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n/an/an/an/a 110n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1/JNK2 (unknown origin)-mediated necrosis


Bioorg Med Chem Lett 23: 4903-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.073
BindingDB Entry DOI: 10.7270/Q2GB2702
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM50229699
PNG
(CHEMBL4059584)
Show SMILES CCC(C)(C)C(=O)N(C)Cc1ccccc1F
Show InChI InChI=1S/C14H20FNO/c1-5-14(2,3)13(17)16(4)10-11-8-6-7-9-12(11)15/h6-9H,5,10H2,1-4H3
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n/an/an/an/a 125n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
BindingDB Entry DOI: 10.7270/Q2QC05QD
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50492948
PNG
(CHEMBL2414915)
Show SMILES Fc1ccc2[nH]c-3c(CCc4c[nH]nc-34)c2c1
Show InChI InChI=1S/C13H10FN3/c14-8-2-4-11-10(5-8)9-3-1-7-6-15-17-12(7)13(9)16-11/h2,4-6,16H,1,3H2,(H,15,17)
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n/an/an/an/a 140n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1/JNK2 (unknown origin)-mediated necrosis


Bioorg Med Chem Lett 23: 4903-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.073
BindingDB Entry DOI: 10.7270/Q2GB2702
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50492956
PNG
(CHEMBL2414926)
Show SMILES C1Oc2cc3[nH]c-4c(CCc5c[nH]nc-45)c3cc2O1
Show InChI InChI=1S/C14H11N3O2/c1-2-8-9-3-11-12(19-6-18-11)4-10(9)16-14(8)13-7(1)5-15-17-13/h3-5,16H,1-2,6H2,(H,15,17)
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n/an/an/an/a 150n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1/JNK2 (unknown origin)-mediated necrosis


Bioorg Med Chem Lett 23: 4903-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.073
BindingDB Entry DOI: 10.7270/Q2GB2702
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50492964
PNG
(CHEMBL2414917)
Show SMILES COc1ccc2[nH]c-3c(CCc4c[nH]nc-34)c2c1
Show InChI InChI=1S/C14H13N3O/c1-18-9-3-5-12-11(6-9)10-4-2-8-7-15-17-13(8)14(10)16-12/h3,5-7,16H,2,4H2,1H3,(H,15,17)
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n/an/an/an/a 170n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1/JNK2 (unknown origin)-mediated necrosis


Bioorg Med Chem Lett 23: 4903-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.073
BindingDB Entry DOI: 10.7270/Q2GB2702
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM36371
PNG
(5-(1H-indol-3-ylmethyl)-3-methyl-2-thioxo-4-Imidaz...)
Show SMILES CN1C(=S)NC(Cc2c[nH]c3ccccc23)C1=O
Show InChI InChI=1S/C13H13N3OS/c1-16-12(17)11(15-13(16)18)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,11,14H,6H2,1H3,(H,15,18)
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n/an/an/an/a 182n/an/a7.330



Tufts University



Assay Description
In vitro kinase assay using RIP1


Nat Chem Biol 4: 313-21 (2008)


Article DOI: 10.1038/nchembio.83
BindingDB Entry DOI: 10.7270/Q21V5C91
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM50228872
PNG
(CHEMBL4091760)
Show SMILES CCC(C)(C)C(=O)N(O)Cc1ccc(F)cc1F
Show InChI InChI=1S/C13H17F2NO2/c1-4-13(2,3)12(17)16(18)8-9-5-6-10(14)7-11(9)15/h5-7,18H,4,8H2,1-3H3
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n/an/an/an/a 198n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
BindingDB Entry DOI: 10.7270/Q2QC05QD
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM50229541
PNG
(CHEMBL4096270)
Show SMILES CCC(C)(C)C(=O)N(C)Cc1cccs1
Show InChI InChI=1S/C12H19NOS/c1-5-12(2,3)11(14)13(4)9-10-7-6-8-15-10/h6-8H,5,9H2,1-4H3
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n/an/an/an/a 221n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
BindingDB Entry DOI: 10.7270/Q2QC05QD
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50492946
PNG
(CHEMBL2414920)
Show SMILES FC(F)(F)c1ccc2c3CCc4c[nH]nc4-c3[nH]c2c1
Show InChI InChI=1S/C14H10F3N3/c15-14(16,17)8-2-4-9-10-3-1-7-6-18-20-12(7)13(10)19-11(9)5-8/h2,4-6,19H,1,3H2,(H,18,20)
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n/an/an/an/a 250n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1/JNK2 (unknown origin)-mediated necrosis


Bioorg Med Chem Lett 23: 4903-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.073
BindingDB Entry DOI: 10.7270/Q2GB2702
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50492947
PNG
(CHEMBL2414919)
Show SMILES Clc1ccc2c3CCc4c[nH]nc4-c3[nH]c2c1
Show InChI InChI=1S/C13H10ClN3/c14-8-2-4-9-10-3-1-7-6-15-17-12(7)13(10)16-11(9)5-8/h2,4-6,16H,1,3H2,(H,15,17)
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n/an/an/an/a 250n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1/JNK2 (unknown origin)-mediated necrosis


Bioorg Med Chem Lett 23: 4903-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.073
BindingDB Entry DOI: 10.7270/Q2GB2702
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM422046
PNG
(US10508102, Compound A)
Show SMILES Fc1ccc2cc[nH]c2c1Cl
Show InChI InChI=1S/C8H5ClFN/c9-7-6(10)2-1-5-3-4-11-8(5)7/h1-4,11H
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US Patent
n/an/an/an/a 256n/an/an/an/a



President and Fellows of Harvard College; Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences

US Patent


Assay Description
RIP1 kinase assays were performed using ADP-Glo assay (Promega) according to manufacturer's protocol. Reactions were performed in 50 mM HEPES, pH...


US Patent US10508102 (2019)


BindingDB Entry DOI: 10.7270/Q28S4S93
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM50228871
PNG
(CHEMBL4099502)
Show SMILES CCC(C)(C)C(=O)N(O)Cc1ccc(F)c(F)c1F
Show InChI InChI=1S/C13H16F3NO2/c1-4-13(2,3)12(18)17(19)7-8-5-6-9(14)11(16)10(8)15/h5-6,19H,4,7H2,1-3H3
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n/an/an/an/a 262n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
BindingDB Entry DOI: 10.7270/Q2QC05QD
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM50229517
PNG
(CHEMBL4068805)
Show SMILES CCC(C)(C)C(=O)N(C)Cc1ccc(C)s1
Show InChI InChI=1S/C13H21NOS/c1-6-13(3,4)12(15)14(5)9-11-8-7-10(2)16-11/h7-8H,6,9H2,1-5H3
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n/an/an/an/a 378n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
BindingDB Entry DOI: 10.7270/Q2QC05QD
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM50229601
PNG
(CHEMBL4082828)
Show SMILES CCC(C)(C)C(=O)N(C)Cc1ccccc1
Show InChI InChI=1S/C14H21NO/c1-5-14(2,3)13(16)15(4)11-12-9-7-6-8-10-12/h6-10H,5,11H2,1-4H3
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n/an/an/an/a 457n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
BindingDB Entry DOI: 10.7270/Q2QC05QD
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM50229242
PNG
(CHEMBL4084908)
Show SMILES CN(Cc1cc(F)cc(F)c1F)C(=O)C1(C)CCCCC1
Show InChI InChI=1S/C16H20F3NO/c1-16(6-4-3-5-7-16)15(21)20(2)10-11-8-12(17)9-13(18)14(11)19/h8-9H,3-7,10H2,1-2H3
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n/an/an/an/a 490n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
BindingDB Entry DOI: 10.7270/Q2QC05QD
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM24713
PNG
(1,2,4,5-tetrahydropyrazolo[3,4-a]carbazole | 3,4,1...)
Show SMILES C1Cc2c([nH]c3ccccc23)-c2n[nH]cc12
Show InChI InChI=1S/C13H11N3/c1-2-4-11-9(3-1)10-6-5-8-7-14-16-12(8)13(10)15-11/h1-4,7,15H,5-6H2,(H,14,16)
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n/an/an/an/a 500n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1/JNK2 (unknown origin)-mediated necrosis


Bioorg Med Chem Lett 23: 4903-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.073
BindingDB Entry DOI: 10.7270/Q2GB2702
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM50229586
PNG
(CHEMBL4087013)
Show SMILES CCC(C)(C)C(=O)N(C)Cc1ccc(F)cc1F
Show InChI InChI=1S/C14H19F2NO/c1-5-14(2,3)13(18)17(4)9-10-6-7-11(15)8-12(10)16/h6-8H,5,9H2,1-4H3
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n/an/an/an/a 627n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
BindingDB Entry DOI: 10.7270/Q2QC05QD
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM50229701
PNG
(CHEMBL4078224)
Show SMILES CCC(C)(C)C(=O)N(C)Cc1cccc(Cl)c1
Show InChI InChI=1S/C14H20ClNO/c1-5-14(2,3)13(17)16(4)10-11-7-6-8-12(15)9-11/h6-9H,5,10H2,1-4H3
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n/an/an/an/a 628n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
BindingDB Entry DOI: 10.7270/Q2QC05QD
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM50229515
PNG
(CHEMBL4076266)
Show SMILES CCC(C)(C)C(=O)N(C)Cc1ccco1
Show InChI InChI=1S/C12H19NO2/c1-5-12(2,3)11(14)13(4)9-10-7-6-8-15-10/h6-8H,5,9H2,1-4H3
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n/an/an/an/a 628n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
BindingDB Entry DOI: 10.7270/Q2QC05QD
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50389604
PNG
(CHEMBL1929485)
Show SMILES C1Cc2c[nH]nc2-c2[nH]c3ccccc3c2C1
Show InChI InChI=1S/C14H13N3/c1-2-7-12-10(5-1)11-6-3-4-9-8-15-17-13(9)14(11)16-12/h1-2,5,7-8,16H,3-4,6H2,(H,15,17)
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n/an/an/an/a 640n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1/JNK2 (unknown origin)-mediated necrosis


Bioorg Med Chem Lett 23: 4903-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.073
BindingDB Entry DOI: 10.7270/Q2GB2702
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM50229429
PNG
(CHEMBL4092663)
Show SMILES CN(Cc1cc(F)cc(F)c1F)C(=O)C1(CCC1)C(F)(F)F
Show InChI InChI=1S/C14H13F6NO/c1-21(7-8-5-9(15)6-10(16)11(8)17)12(22)13(3-2-4-13)14(18,19)20/h5-6H,2-4,7H2,1H3
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n/an/an/an/a 656n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
BindingDB Entry DOI: 10.7270/Q2QC05QD
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50492958
PNG
(CHEMBL2414985)
Show SMILES Clc1cccc2[nH]c-3c(CCc4c[nH]nc-34)c12
Show InChI InChI=1S/C13H10ClN3/c14-9-2-1-3-10-11(9)8-5-4-7-6-15-17-12(7)13(8)16-10/h1-3,6,16H,4-5H2,(H,15,17)
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n/an/an/an/a 670n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1/JNK2 (unknown origin)-mediated necrosis


Bioorg Med Chem Lett 23: 4903-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.073
BindingDB Entry DOI: 10.7270/Q2GB2702
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50492951
PNG
(CHEMBL2414983)
Show SMILES Cc1cccc2c3CCc4c[nH]nc4-c3[nH]c12
Show InChI InChI=1S/C14H13N3/c1-8-3-2-4-10-11-6-5-9-7-15-17-13(9)14(11)16-12(8)10/h2-4,7,16H,5-6H2,1H3,(H,15,17)
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n/an/an/an/a 760n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1/JNK2 (unknown origin)-mediated necrosis


Bioorg Med Chem Lett 23: 4903-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.073
BindingDB Entry DOI: 10.7270/Q2GB2702
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50492963
PNG
(CHEMBL2414916)
Show SMILES CCc1ccc2[nH]c-3c(CCc4c[nH]nc-34)c2c1
Show InChI InChI=1S/C15H15N3/c1-2-9-3-6-13-12(7-9)11-5-4-10-8-16-18-14(10)15(11)17-13/h3,6-8,17H,2,4-5H2,1H3,(H,16,18)
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n/an/an/an/a 780n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1/JNK2 (unknown origin)-mediated necrosis


Bioorg Med Chem Lett 23: 4903-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.073
BindingDB Entry DOI: 10.7270/Q2GB2702
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50492962
PNG
(CHEMBL2414981)
Show SMILES CC1Cc2c([nH]c3ccccc23)-c2n[nH]cc12
Show InChI InChI=1S/C14H13N3/c1-8-6-10-9-4-2-3-5-12(9)16-13(10)14-11(8)7-15-17-14/h2-5,7-8,16H,6H2,1H3,(H,15,17)
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n/an/an/an/a 810n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1/JNK2 (unknown origin)-mediated necrosis


Bioorg Med Chem Lett 23: 4903-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.073
BindingDB Entry DOI: 10.7270/Q2GB2702
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM50229587
PNG
(CHEMBL4080685)
Show SMILES CCC(C)(C)C(=O)N(C)Cc1ccc(F)cc1
Show InChI InChI=1S/C14H20FNO/c1-5-14(2,3)13(17)16(4)10-11-6-8-12(15)9-7-11/h6-9H,5,10H2,1-4H3
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n/an/an/an/a 815n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
BindingDB Entry DOI: 10.7270/Q2QC05QD
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50492959
PNG
(CHEMBL2414982)
Show SMILES Fc1cccc2c3CCc4c[nH]nc4-c3[nH]c12
Show InChI InChI=1S/C13H10FN3/c14-10-3-1-2-8-9-5-4-7-6-15-17-11(7)13(9)16-12(8)10/h1-3,6,16H,4-5H2,(H,15,17)
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PubMed
n/an/an/an/a 860n/an/an/an/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1/JNK2 (unknown origin)-mediated necrosis


Bioorg Med Chem Lett 23: 4903-6 (2013)


Article DOI: 10.1016/j.bmcl.2013.06.073
BindingDB Entry DOI: 10.7270/Q2GB2702
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM50229603
PNG
(CHEMBL4090332)
Show SMILES CCC(C)(C)C(=O)NCc1ccccc1F
Show InChI InChI=1S/C13H18FNO/c1-4-13(2,3)12(16)15-9-10-7-5-6-8-11(10)14/h5-8H,4,9H2,1-3H3,(H,15,16)
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n/an/an/an/a 898n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
BindingDB Entry DOI: 10.7270/Q2QC05QD
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM50229028
PNG
(CHEMBL4066793)
Show SMILES CCC(C)(C)C(=O)NC(CO)c1ccccc1
Show InChI InChI=1S/C14H21NO2/c1-4-14(2,3)13(17)15-12(10-16)11-8-6-5-7-9-11/h5-9,12,16H,4,10H2,1-3H3,(H,15,17)
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n/an/an/an/a 1.08E+3n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
BindingDB Entry DOI: 10.7270/Q2QC05QD
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM50229597
PNG
(CHEMBL4104038)
Show SMILES CCC(C)(C)C(=O)N(C)Cc1cccc(Br)c1
Show InChI InChI=1S/C14H20BrNO/c1-5-14(2,3)13(17)16(4)10-11-7-6-8-12(15)9-11/h6-9H,5,10H2,1-4H3
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n/an/an/an/a 1.23E+3n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
BindingDB Entry DOI: 10.7270/Q2QC05QD
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM50229422
PNG
(CHEMBL4102856)
Show SMILES CN(Cc1cc(F)cc(F)c1F)C(=O)C1(CCCC1)C(F)(F)F
Show InChI InChI=1S/C15H15F6NO/c1-22(8-9-6-10(16)7-11(17)12(9)18)13(23)14(15(19,20)21)4-2-3-5-14/h6-7H,2-5,8H2,1H3
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n/an/an/an/a 1.23E+3n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
BindingDB Entry DOI: 10.7270/Q2QC05QD
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM50229583
PNG
(CHEMBL4063537)
Show SMILES CCC(C)(C)C(=O)N(C)Cc1c(F)cc(F)cc1F
Show InChI InChI=1S/C14H18F3NO/c1-5-14(2,3)13(19)18(4)8-10-11(16)6-9(15)7-12(10)17/h6-7H,5,8H2,1-4H3
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n/an/an/an/a 1.25E+3n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
BindingDB Entry DOI: 10.7270/Q2QC05QD
More data for this
Ligand-Target Pair
Receptor-interacting protein 1 (RIPK1)


(Homo sapiens (Human))
BDBM50229610
PNG
(CHEMBL4073983)
Show SMILES CCC(C)(C)C(=O)N(C)Cc1cc(C)c(C)s1
Show InChI InChI=1S/C14H23NOS/c1-7-14(4,5)13(16)15(6)9-12-8-10(2)11(3)17-12/h8H,7,9H2,1-6H3
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n/an/an/an/a 1.31E+3n/an/an/an/a



National Institute of Biological Sciences

Curated by ChEMBL


Assay Description
Inhibition of RIP1 in human HT-29 cells assessed as reduction in TNFalpha/z-VAD-FMK-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell ...


J Med Chem 60: 972-986 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01196
BindingDB Entry DOI: 10.7270/Q2QC05QD
More data for this
Ligand-Target Pair
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