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Compile Data Set for Download or QSAR

Found 902 hits of ic50 for UniProtKB: A0A024R328   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 0.0800n/an/an/an/an/an/a



Millennium Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition Protein kinase C (PKC)


J Med Chem 45: 3772-93 (2002)


Article DOI: 10.1021/jm020143r
BindingDB Entry DOI: 10.7270/Q2WW7JD9
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50519062
PNG
(CHEMBL4442196)
Show SMILES C[C@@H]1[C@H](OC(=O)c2ccccc2)[C@]2(O)[C@H]3[C@H]1[C@H](C)CCCCCC[C@@H](OC(C)=O)C14O[C@@H]5[C@H]([C@@H]6O[C@]6(CO)[C@H]2O)[C@]3(O1)[C@H](COC(=O)c1ccccc1)C[C@@]5(O4)C(C)=C
Show InChI InChI=1S/C46H56O13/c1-25(2)42-22-31(23-53-39(49)29-17-11-8-12-18-29)45-34-37(42)57-46(58-42,59-45)32(54-28(5)48)21-15-7-6-10-16-26(3)33-27(4)36(55-40(50)30-19-13-9-14-20-30)44(52,35(33)45)41(51)43(24-47)38(34)56-43/h8-9,11-14,17-20,26-27,31-38,41,47,51-52H,1,6-7,10,15-16,21-24H2,2-5H3/t26-,27+,31+,32-,33+,34-,35-,36+,37-,38+,41-,42-,43+,44-,45-,46?/m1/s1
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n/an/a 0.0900n/an/an/an/an/an/a



Toho University

Curated by ChEMBL


Assay Description
Agonist activity at Protein kinase C in human MT4 cells infected with HIV-1 NL4-3 assessed as inhibition of viral replication measured on day 3 post-...


J Med Chem 62: 6958-6971 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00339
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50393214
PNG
(CHEMBL2151411)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3c(C)cccc23)c2ccccc2n1
Show InChI InChI=1S/C26H24N6O2/c1-15-6-5-8-16-18(14-27-22(15)16)20-21(25(34)30-24(20)33)23-17-7-3-4-9-19(17)28-26(29-23)32-12-10-31(2)11-13-32/h3-9,14,27H,10-13H2,1-2H3,(H,30,33,34)
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n/an/a 0.100n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCdelta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50519087
PNG
(CHEMBL3741746)
Show SMILES C[C@@H]1[C@H](OC(=O)c2ccccc2)[C@]2(O)[C@H]3[C@H]1[C@H](C)CCCCCC[C@@H](O)C14O[C@@H]5[C@H]([C@@H]6O[C@]6(CO)[C@H]2O)[C@]3(O1)[C@H](COC(=O)c1ccccc1)C[C@@]5(O4)C(C)=C
Show InChI InChI=1S/C44H54O12/c1-24(2)40-21-29(22-51-37(47)27-16-10-7-11-17-27)43-32-35(40)54-44(55-40,56-43)30(46)20-14-6-5-9-15-25(3)31-26(4)34(52-38(48)28-18-12-8-13-19-28)42(50,33(31)43)39(49)41(23-45)36(32)53-41/h7-8,10-13,16-19,25-26,29-36,39,45-46,49-50H,1,5-6,9,14-15,20-23H2,2-4H3/t25-,26+,29+,30-,31+,32-,33-,34+,35-,36+,39-,40-,41+,42-,43-,44?/m1/s1
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n/an/a 0.130n/an/an/an/an/an/a



Toho University

Curated by ChEMBL


Assay Description
Agonist activity at Protein kinase C in human MT4 cells infected with HIV-1 NL4-3 assessed as inhibition of viral replication measured on day 3 post-...


J Med Chem 62: 6958-6971 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00339
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50519068
PNG
(CHEMBL4575056)
Show SMILES C[C@@H]1[C@H](OC(=O)c2ccccc2)[C@]2(O)[C@H]3[C@H]1[C@H](C)CCCCCCC(=O)C14O[C@@H]5[C@H]([C@@H]6O[C@]6(CO)[C@H]2O)[C@]3(O1)[C@H](COC(=O)c1ccccc1)C[C@@]5(O4)C(C)=C
Show InChI InChI=1S/C44H52O12/c1-24(2)40-21-29(22-51-37(47)27-16-10-7-11-17-27)43-32-35(40)54-44(55-40,56-43)30(46)20-14-6-5-9-15-25(3)31-26(4)34(52-38(48)28-18-12-8-13-19-28)42(50,33(31)43)39(49)41(23-45)36(32)53-41/h7-8,10-13,16-19,25-26,29,31-36,39,45,49-50H,1,5-6,9,14-15,20-23H2,2-4H3/t25-,26+,29+,31+,32-,33-,34+,35-,36+,39-,40-,41+,42-,43-,44?/m1/s1
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n/an/a 0.140n/an/an/an/an/an/a



Toho University

Curated by ChEMBL


Assay Description
Agonist activity at Protein kinase C in human MT4 cells infected with HIV-1 NL4-3 assessed as inhibition of viral replication measured on day 3 post-...


J Med Chem 62: 6958-6971 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00339
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50519060
PNG
(CHEMBL4528495)
Show SMILES C[C@@H]1[C@H](OC(=O)c2ccc3ccccc3c2)[C@]2(O)[C@H]3[C@H]1[C@H](C)CCCCCC[C@@H](O)C14O[C@@H]5[C@H]([C@@H]6O[C@]6(CO)[C@H]2O)[C@]3(O1)[C@H](COC(=O)c1ccccc1)C[C@@]5(O4)C(C)=C
Show InChI InChI=1S/C48H56O12/c1-26(2)44-23-33(24-55-41(51)30-16-9-7-10-17-30)47-36-39(44)58-48(59-44,60-47)34(50)19-11-6-5-8-14-27(3)35-28(4)38(46(54,37(35)47)43(53)45(25-49)40(36)57-45)56-42(52)32-21-20-29-15-12-13-18-31(29)22-32/h7,9-10,12-13,15-18,20-22,27-28,33-40,43,49-50,53-54H,1,5-6,8,11,14,19,23-25H2,2-4H3/t27-,28+,33+,34-,35+,36-,37-,38+,39-,40+,43-,44-,45+,46-,47-,48?/m1/s1
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n/an/a 0.150n/an/an/an/an/an/a



Toho University

Curated by ChEMBL


Assay Description
Agonist activity at Protein kinase C in human MT4 cells infected with HIV-1 NL4-3 assessed as inhibition of viral replication measured on day 3 post-...


J Med Chem 62: 6958-6971 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00339
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50519083
PNG
(CHEMBL4538431)
Show SMILES COc1ccc(cc1)C(=O)O[C@H]1[C@@H](C)[C@H]2[C@@H]3[C@]1(O)[C@H](O)[C@@]1(CO)O[C@H]1[C@H]1[C@H]4OC5(O[C@]4(C[C@@H](COC(=O)c4ccccc4)[C@]31O5)C(C)=C)[C@H](O)CCCCCC[C@H]2C
Show InChI InChI=1S/C45H56O13/c1-24(2)41-21-29(22-53-38(48)27-14-10-8-11-15-27)44-33-36(41)56-45(57-41,58-44)31(47)16-12-7-6-9-13-25(3)32-26(4)35(54-39(49)28-17-19-30(52-5)20-18-28)43(51,34(32)44)40(50)42(23-46)37(33)55-42/h8,10-11,14-15,17-20,25-26,29,31-37,40,46-47,50-51H,1,6-7,9,12-13,16,21-23H2,2-5H3/t25-,26+,29+,31-,32+,33-,34-,35+,36-,37+,40-,41-,42+,43-,44-,45?/m1/s1
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n/an/a 0.170n/an/an/an/an/an/a



Toho University

Curated by ChEMBL


Assay Description
Agonist activity at Protein kinase C in human MT4 cells infected with HIV-1 NL4-3 assessed as inhibition of viral replication measured on day 3 post-...


J Med Chem 62: 6958-6971 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00339
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50519084
PNG
(CHEMBL4443190)
Show SMILES CC(C)[C@]12C[C@@H](COC(=O)c3ccccc3)[C@@]34OC5(O[C@@H]1[C@@H]3[C@@H]1O[C@]1(CO)[C@@H](O)[C@]1(O)[C@@H](OC(=O)c3ccccc3)[C@@H](C)[C@@H]([C@@H]41)[C@H](C)CCCCCC[C@H]5O)O2
Show InChI InChI=1S/C44H56O12/c1-24(2)40-21-29(22-51-37(47)27-16-10-7-11-17-27)43-32-35(40)54-44(55-40,56-43)30(46)20-14-6-5-9-15-25(3)31-26(4)34(52-38(48)28-18-12-8-13-19-28)42(50,33(31)43)39(49)41(23-45)36(32)53-41/h7-8,10-13,16-19,24-26,29-36,39,45-46,49-50H,5-6,9,14-15,20-23H2,1-4H3/t25-,26+,29+,30-,31+,32-,33-,34+,35-,36+,39-,40-,41+,42-,43-,44?/m1/s1
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n/an/a 0.180n/an/an/an/an/an/a



Toho University

Curated by ChEMBL


Assay Description
Agonist activity at Protein kinase C in human MT4 cells infected with HIV-1 NL4-3 assessed as inhibition of viral replication measured on day 3 post-...


J Med Chem 62: 6958-6971 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00339
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50519069
PNG
(CHEMBL4435580)
Show SMILES C[C@@H]1[C@H](OC(=O)c2ccc(cc2)[N+]([O-])=O)[C@]2(O)[C@H]3[C@H]1[C@H](C)CCCCCC[C@@H](O)C14O[C@@H]5[C@H]([C@@H]6O[C@]6(CO)[C@H]2O)[C@]3(O1)[C@H](COC(=O)c1ccccc1)C[C@@]5(O4)C(C)=C
Show InChI InChI=1S/C44H53NO14/c1-23(2)40-20-28(21-54-37(48)26-13-9-7-10-14-26)43-32-35(40)57-44(58-40,59-43)30(47)15-11-6-5-8-12-24(3)31-25(4)34(55-38(49)27-16-18-29(19-17-27)45(52)53)42(51,33(31)43)39(50)41(22-46)36(32)56-41/h7,9-10,13-14,16-19,24-25,28,30-36,39,46-47,50-51H,1,5-6,8,11-12,15,20-22H2,2-4H3/t24-,25+,28+,30-,31+,32-,33-,34+,35-,36+,39-,40-,41+,42-,43-,44?/m1/s1
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n/an/a 0.220n/an/an/an/an/an/a



Toho University

Curated by ChEMBL


Assay Description
Agonist activity at Protein kinase C in human MT4 cells infected with HIV-1 NL4-3 assessed as inhibition of viral replication measured on day 3 post-...


J Med Chem 62: 6958-6971 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00339
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50466809
PNG
(CHEMBL4281395)
Show SMILES COc1c(OC)c2SSSSSc2c(CCN)c1SC
Show InChI InChI=1S/C11H15NO2S6/c1-13-7-8(14-2)11-10(16-18-20-19-17-11)6(4-5-12)9(7)15-3/h4-5,12H2,1-3H3
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n/an/a 0.300n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of protein kinase C (unknown origin)


J Nat Prod 80: 3060-3079 (2017)


Article DOI: 10.1021/acs.jnatprod.7b00575
BindingDB Entry DOI: 10.7270/Q2RN3BJF
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50466813
PNG
(CHEMBL222469)
Show SMILES COc1c2SSSc2c(CCN(C)C)c(SC)c1OC
Show InChI InChI=1S/C13H19NO2S4/c1-14(2)7-6-8-11(17-5)9(15-3)10(16-4)13-12(8)18-20-19-13/h6-7H2,1-5H3
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n/an/a 0.300n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of protein kinase C (unknown origin)


J Nat Prod 80: 3060-3079 (2017)


Article DOI: 10.1021/acs.jnatprod.7b00575
BindingDB Entry DOI: 10.7270/Q2RN3BJF
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50466812
PNG
(CHEMBL4291190)
Show SMILES NCCc1cc(O)c(O)c2SSSSSc12
Show InChI InChI=1S/C8H9NO2S5/c9-2-1-4-3-5(10)6(11)8-7(4)12-14-16-15-13-8/h3,10-11H,1-2,9H2
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n/an/a 0.300n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of protein kinase C (unknown origin)


J Nat Prod 80: 3060-3079 (2017)


Article DOI: 10.1021/acs.jnatprod.7b00575
BindingDB Entry DOI: 10.7270/Q2RN3BJF
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50466811
PNG
(CHEMBL222470)
Show SMILES COc1c(OC)c2SSSSSc2c(CCN(C)C)c1SC
Show InChI InChI=1S/C13H19NO2S6/c1-14(2)7-6-8-11(17-5)9(15-3)10(16-4)13-12(8)18-20-22-21-19-13/h6-7H2,1-5H3
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n/an/a 0.300n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of protein kinase C (unknown origin)


J Nat Prod 80: 3060-3079 (2017)


Article DOI: 10.1021/acs.jnatprod.7b00575
BindingDB Entry DOI: 10.7270/Q2RN3BJF
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50466810
PNG
(CHEMBL4284802)
Show SMILES COc1c2SSSc2c(CCN)c(SC)c1OC
Show InChI InChI=1S/C11H15NO2S4/c1-13-7-8(14-2)11-10(16-18-17-11)6(4-5-12)9(7)15-3/h4-5,12H2,1-3H3
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n/an/a 0.300n/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Inhibition of protein kinase C (unknown origin)


J Nat Prod 80: 3060-3079 (2017)


Article DOI: 10.1021/acs.jnatprod.7b00575
BindingDB Entry DOI: 10.7270/Q2RN3BJF
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50519063
PNG
(CHEMBL4587471)
Show SMILES C[C@@H]1[C@H](OC(=O)c2ccncc2)[C@]2(O)[C@H]3[C@H]1[C@H](C)CCCCCC[C@@H](O)C14O[C@@H]5[C@H]([C@@H]6O[C@]6(CO)[C@H]2O)[C@]3(O1)[C@H](COC(=O)c1ccccc1)C[C@@]5(O4)C(C)=C
Show InChI InChI=1S/C43H53NO12/c1-23(2)39-20-28(21-51-36(47)26-13-9-7-10-14-26)42-31-34(39)54-43(55-39,56-42)29(46)15-11-6-5-8-12-24(3)30-25(4)33(52-37(48)27-16-18-44-19-17-27)41(50,32(30)42)38(49)40(22-45)35(31)53-40/h7,9-10,13-14,16-19,24-25,28-35,38,45-46,49-50H,1,5-6,8,11-12,15,20-22H2,2-4H3/t24-,25+,28+,29-,30+,31-,32-,33+,34-,35+,38-,39-,40+,41-,42-,43?/m1/s1
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n/an/a 0.360n/an/an/an/an/an/a



Toho University

Curated by ChEMBL


Assay Description
Agonist activity at Protein kinase C in human MT4 cells infected with HIV-1 NL4-3 assessed as inhibition of viral replication measured on day 3 post-...


J Med Chem 62: 6958-6971 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00339
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50393218
PNG
(CHEMBL1996510)
Show SMILES O=C1NC(=O)C(=C1c1c[nH]c2ccccc12)c1nc(nc2ccccc12)N1CCNCC1
Show InChI InChI=1S/C24H20N6O2/c31-22-19(16-13-26-17-7-3-1-5-14(16)17)20(23(32)29-22)21-15-6-2-4-8-18(15)27-24(28-21)30-11-9-25-10-12-30/h1-8,13,25-26H,9-12H2,(H,29,31,32)
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n/an/a 0.400n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCdelta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50393228
PNG
(CHEMBL2153750)
Show SMILES CN1CCN(CC1)c1nc(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2cc(F)ccc2n1
Show InChI InChI=1S/C25H21FN6O2/c1-31-8-10-32(11-9-31)25-28-19-7-6-14(26)12-16(19)22(29-25)21-20(23(33)30-24(21)34)17-13-27-18-5-3-2-4-15(17)18/h2-7,12-13,27H,8-11H2,1H3,(H,30,33,34)
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n/an/a 0.600n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCdelta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 0.600n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of protein kinase C


Citation and Details

BindingDB Entry DOI: 10.7270/Q27946V3
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Protein kinase C delta type


(Homo sapiens (Human))
BDBM3153
PNG
(2-{[2,6-dihydroxy-4-({[(1R,2R)-2-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCC[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C27H23NO10/c29-15-9-7-13(8-10-15)25(34)28-17-4-2-6-21(17)38-27(37)14-11-19(31)23(20(32)12-14)24(33)22-16(26(35)36)3-1-5-18(22)30/h1,3,5,7-12,17,21,29-32H,2,4,6H2,(H,28,34)(H,35,36)/t17-,21-/m1/s1
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n/an/a 0.900n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human Protein kinase C delta


Bioorg Med Chem Lett 5: 2151-2154 (1995)


Article DOI: 10.1016/0960-894X(95)00365-Z
BindingDB Entry DOI: 10.7270/Q2MP536X
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM3153
PNG
(2-{[2,6-dihydroxy-4-({[(1R,2R)-2-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCC[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C27H23NO10/c29-15-9-7-13(8-10-15)25(34)28-17-4-2-6-21(17)38-27(37)14-11-19(31)23(20(32)12-14)24(33)22-16(26(35)36)3-1-5-18(22)30/h1,3,5,7-12,17,21,29-32H,2,4,6H2,(H,28,34)(H,35,36)/t17-,21-/m1/s1
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n/an/a 0.900n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Protein kinase C delta expressed in Sf-9 cells


Bioorg Med Chem Lett 5: 2133-2138 (1995)


Article DOI: 10.1016/0960-894X(95)00361-V
BindingDB Entry DOI: 10.7270/Q2W66KQG
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM3153
PNG
(2-{[2,6-dihydroxy-4-({[(1R,2R)-2-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCC[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C27H23NO10/c29-15-9-7-13(8-10-15)25(34)28-17-4-2-6-21(17)38-27(37)14-11-19(31)23(20(32)12-14)24(33)22-16(26(35)36)3-1-5-18(22)30/h1,3,5,7-12,17,21,29-32H,2,4,6H2,(H,28,34)(H,35,36)/t17-,21-/m1/s1
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n/an/a 0.900n/an/an/an/an/an/a



Sphinx Pharmaceuticals



Assay Description
The activity of PKC, activated by phosphatidylerine and Ca2+, is measured by its ability to transfer phosphate from [gamma-32P]ATP to lysine-rich his...


Bioorg Med Chem Lett 5: 2133-8 (1995)


Article DOI: 10.1016/j.bmcl.2005.09.037
BindingDB Entry DOI: 10.7270/Q26T0JT4
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM3183
PNG
(2-({2,6-dihydroxy-4-[({2-[(4-hydroxybenzene)amido]...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)OC1CCCC1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C27H23NO10/c29-15-9-7-13(8-10-15)25(34)28-17-4-2-6-21(17)38-27(37)14-11-19(31)23(20(32)12-14)24(33)22-16(26(35)36)3-1-5-18(22)30/h1,3,5,7-12,17,21,29-32H,2,4,6H2,(H,28,34)(H,35,36)
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n/an/a 0.900n/an/an/an/a7.530



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


J Med Chem 39: 5215-27 (1996)


Article DOI: 10.1021/jm960581w
BindingDB Entry DOI: 10.7270/Q2G73BVV
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM3153
PNG
(2-{[2,6-dihydroxy-4-({[(1R,2R)-2-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCC[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C27H23NO10/c29-15-9-7-13(8-10-15)25(34)28-17-4-2-6-21(17)38-27(37)14-11-19(31)23(20(32)12-14)24(33)22-16(26(35)36)3-1-5-18(22)30/h1,3,5,7-12,17,21,29-32H,2,4,6H2,(H,28,34)(H,35,36)/t17-,21-/m1/s1
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n/an/a 0.900n/an/an/an/an/an/a



Sphinx Laboratories



Assay Description
PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.


Bioorg Med Chem Lett 5: 2151-4 (1995)


Article DOI: 10.1016/0960-894X(95)00365-Z
BindingDB Entry DOI: 10.7270/Q2VH5M1B
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM3153
PNG
(2-{[2,6-dihydroxy-4-({[(1R,2R)-2-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCC[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C27H23NO10/c29-15-9-7-13(8-10-15)25(34)28-17-4-2-6-21(17)38-27(37)14-11-19(31)23(20(32)12-14)24(33)22-16(26(35)36)3-1-5-18(22)30/h1,3,5,7-12,17,21,29-32H,2,4,6H2,(H,28,34)(H,35,36)/t17-,21-/m1/s1
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n/an/a 0.900n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of protein kinase C delta


Bioorg Med Chem Lett 6: 973-978 (1996)


Article DOI: 10.1016/0960-894X(96)00151-5
BindingDB Entry DOI: 10.7270/Q23B603M
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM3153
PNG
(2-{[2,6-dihydroxy-4-({[(1R,2R)-2-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCC[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C27H23NO10/c29-15-9-7-13(8-10-15)25(34)28-17-4-2-6-21(17)38-27(37)14-11-19(31)23(20(32)12-14)24(33)22-16(26(35)36)3-1-5-18(22)30/h1,3,5,7-12,17,21,29-32H,2,4,6H2,(H,28,34)(H,35,36)/t17-,21-/m1/s1
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n/an/a 0.900n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of human Protein kinase C delta


Bioorg Med Chem Lett 5: 2155-2160 (1995)


Article DOI: 10.1016/0960-894X(95)00367-3
BindingDB Entry DOI: 10.7270/Q22N52RC
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM3153
PNG
(2-{[2,6-dihydroxy-4-({[(1R,2R)-2-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCC[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C27H23NO10/c29-15-9-7-13(8-10-15)25(34)28-17-4-2-6-21(17)38-27(37)14-11-19(31)23(20(32)12-14)24(33)22-16(26(35)36)3-1-5-18(22)30/h1,3,5,7-12,17,21,29-32H,2,4,6H2,(H,28,34)(H,35,36)/t17-,21-/m1/s1
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n/an/a 0.900n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Human Protein kinase C delta


Bioorg Med Chem Lett 5: 1839-1842 (1995)


Article DOI: 10.1016/0960-894X(95)00303-B
BindingDB Entry DOI: 10.7270/Q2QN66R9
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50519061
PNG
(CHEMBL4533733)
Show SMILES C[C@@H]1[C@H](OC(=O)\C=C\c2ccccc2)[C@]2(O)[C@H]3[C@H]1[C@H](C)CCCCCC[C@@H](O)C14O[C@@H]5[C@H]([C@@H]6O[C@]6(CO)[C@H]2O)[C@]3(O1)[C@H](COC(=O)c1ccccc1)C[C@@]5(O4)C(C)=C
Show InChI InChI=1S/C46H56O12/c1-26(2)42-23-31(24-53-40(50)30-18-12-8-13-19-30)45-35-38(42)56-46(57-42,58-45)32(48)20-14-6-5-9-15-27(3)34-28(4)37(54-33(49)22-21-29-16-10-7-11-17-29)44(52,36(34)45)41(51)43(25-47)39(35)55-43/h7-8,10-13,16-19,21-22,27-28,31-32,34-39,41,47-48,51-52H,1,5-6,9,14-15,20,23-25H2,2-4H3/b22-21+/t27-,28+,31+,32-,34+,35-,36-,37+,38-,39+,41-,42-,43+,44-,45-,46?/m1/s1
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n/an/a>1n/an/an/an/an/an/a



Toho University

Curated by ChEMBL


Assay Description
Agonist activity at Protein kinase C in human MT4 cells infected with HIV-1 NL4-3 assessed as inhibition of viral replication measured on day 3 post-...


J Med Chem 62: 6958-6971 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00339
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50393219
PNG
(CHEMBL2151415)
Show SMILES Cn1cc(C2=C(C(=O)NC2=O)c2nc(nc3ccccc23)N2CCNCC2)c2ccccc12
Show InChI InChI=1S/C25H22N6O2/c1-30-14-17(15-6-3-5-9-19(15)30)20-21(24(33)29-23(20)32)22-16-7-2-4-8-18(16)27-25(28-22)31-12-10-26-11-13-31/h2-9,14,26H,10-13H2,1H3,(H,29,32,33)
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n/an/a 1n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of PKCdelta by scintillation proximity assay


J Med Chem 54: 6028-39 (2011)


Article DOI: 10.1021/jm200469u
BindingDB Entry DOI: 10.7270/Q2K35VR1
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM3153
PNG
(2-{[2,6-dihydroxy-4-({[(1R,2R)-2-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCC[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C27H23NO10/c29-15-9-7-13(8-10-15)25(34)28-17-4-2-6-21(17)38-27(37)14-11-19(31)23(20(32)12-14)24(33)22-16(26(35)36)3-1-5-18(22)30/h1,3,5,7-12,17,21,29-32H,2,4,6H2,(H,28,34)(H,35,36)/t17-,21-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



Eli Lilly and Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against recombinant human Protein kinase C delta isozyme


J Med Chem 40: 226-35 (1997)


Article DOI: 10.1021/jm960497g
BindingDB Entry DOI: 10.7270/Q2J965HR
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM3153
PNG
(2-{[2,6-dihydroxy-4-({[(1R,2R)-2-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCC[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C27H23NO10/c29-15-9-7-13(8-10-15)25(34)28-17-4-2-6-21(17)38-27(37)14-11-19(31)23(20(32)12-14)24(33)22-16(26(35)36)3-1-5-18(22)30/h1,3,5,7-12,17,21,29-32H,2,4,6H2,(H,28,34)(H,35,36)/t17-,21-/m1/s1
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TBA

Curated by ChEMBL


Assay Description
Inhibition of protein kinase C delta


Bioorg Med Chem Lett 6: 1759-1764 (1996)


Article DOI: 10.1016/0960-894X(96)00311-3
BindingDB Entry DOI: 10.7270/Q2QR4X3R
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM50285250
PNG
(4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benz...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@H]1CCCC1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C27H23NO10/c29-15-9-7-13(8-10-15)25(34)28-17-4-2-6-21(17)38-27(37)14-11-19(31)23(20(32)12-14)24(33)22-16(26(35)36)3-1-5-18(22)30/h1,3,5,7-12,17,21,29-32H,2,4,6H2,(H,28,34)(H,35,36)/t17?,21-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Protein kinase C delta


Bioorg Med Chem Lett 5: 2211-2216 (1995)


Article DOI: 10.1016/0960-894X(95)00382-4
BindingDB Entry DOI: 10.7270/Q2GX4BHN
More data for this
Ligand-Target Pair
Protein kinase C delta type


(Homo sapiens (Human))
BDBM3153
PNG
(2-{[2,6-dihydroxy-4-({[(1R,2R)-2-[(4-hydroxybenzen...)
Show SMILES OC(=O)c1cccc(O)c1C(=O)c1c(O)cc(cc1O)C(=O)O[C@@H]1CCC[C@H]1NC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C27H23NO10/c29-15-9-7-13(8-10-15)25(34)28-17-4-2-6-21(17)38-27(37)14-11-19(31)23(20(32)12-14)24(33)22-16(26(35)36)3-1-5-18(22)30/h1,3,5,7-12,17,21,29-32H,2,4,6H2,(H,28,34)(H,35,36)/t17-,21-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition of Protein kinase C delta


Bioorg Med Chem Lett 5: 2015-2020 (1995)


Article DOI: 10.1016/0960-894X(95)00344-S
BindingDB Entry DOI: 10.7270/Q29C6XD1
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50519064
PNG
(CHEMBL4586553)
Show SMILES C[C@@H]1[C@H](OC(=O)c2ccccc2)[C@]2(O)[C@H]3[C@H]1[C@H](C)CCCCCC[C@@H](O)C14O[C@@H]5[C@H]([C@@H]6O[C@]6(COC(=O)C(C)(C)CC(O)=O)[C@H]2O)[C@]3(O1)[C@H](COC(=O)c1ccccc1)C[C@@]5(O4)C(C)=C
Show InChI InChI=1S/C50H62O15/c1-27(2)46-23-32(25-59-41(54)30-18-12-9-13-19-30)49-36-39(46)63-50(64-46,65-49)33(51)22-16-8-7-11-17-28(3)35-29(4)38(61-42(55)31-20-14-10-15-21-31)48(58,37(35)49)43(56)47(40(36)62-47)26-60-44(57)45(5,6)24-34(52)53/h9-10,12-15,18-21,28-29,32-33,35-40,43,51,56,58H,1,7-8,11,16-17,22-26H2,2-6H3,(H,52,53)/t28-,29+,32+,33-,35+,36-,37-,38+,39-,40+,43-,46-,47+,48-,49-,50?/m1/s1
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n/an/a>1n/an/an/an/an/an/a



Toho University

Curated by ChEMBL


Assay Description
Agonist activity at Protein kinase C in human MT4 cells infected with HIV-1 NL4-3 assessed as inhibition of viral replication measured on day 3 post-...


J Med Chem 62: 6958-6971 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00339
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50519065
PNG
(CHEMBL4578026)
Show SMILES C[C@@H]1[C@H](OC(=O)c2ccccc2)[C@]2(O)[C@H]3[C@H]1[C@H](C)CCCCCC[C@@H](OC(=O)c1ccccc1)C14O[C@@H]5[C@H]([C@@H]6O[C@]6(CO)[C@H]2O)[C@]3(O1)[C@H](COC(=O)c1ccccc1)C[C@@]5(O4)C(C)=C
Show InChI InChI=1S/C51H58O13/c1-29(2)47-26-35(27-58-43(53)32-19-11-7-12-20-32)50-38-41(47)62-51(63-47,64-50)36(59-44(54)33-21-13-8-14-22-33)25-17-6-5-10-18-30(3)37-31(4)40(60-45(55)34-23-15-9-16-24-34)49(57,39(37)50)46(56)48(28-52)42(38)61-48/h7-9,11-16,19-24,30-31,35-42,46,52,56-57H,1,5-6,10,17-18,25-28H2,2-4H3/t30-,31+,35+,36-,37+,38-,39-,40+,41-,42+,46-,47-,48+,49-,50-,51?/m1/s1
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n/an/a>1n/an/an/an/an/an/a



Toho University

Curated by ChEMBL


Assay Description
Agonist activity at Protein kinase C in human MT4 cells infected with HIV-1 NL4-3 assessed as inhibition of viral replication measured on day 3 post-...


J Med Chem 62: 6958-6971 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00339
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50519066
PNG
(CHEMBL4460926)
Show SMILES C[C@@H]1[C@H](OC(=O)c2ccccc2)[C@]2(O)[C@H]3[C@H]1[C@H](C)CCCCCC[C@@H](O)C14O[C@@H]5[C@H]([C@@H]6O[C@]6(COC(=O)CCC(O)=O)[C@H]2O)[C@]3(O1)[C@H](COC(=O)c1ccccc1)C[C@@]5(O4)C(C)=C
Show InChI InChI=1S/C48H58O15/c1-26(2)44-23-31(24-57-41(53)29-16-10-7-11-17-29)47-36-39(44)61-48(62-44,63-47)32(49)20-14-6-5-9-15-27(3)35-28(4)38(59-42(54)30-18-12-8-13-19-30)46(56,37(35)47)43(55)45(40(36)60-45)25-58-34(52)22-21-33(50)51/h7-8,10-13,16-19,27-28,31-32,35-40,43,49,55-56H,1,5-6,9,14-15,20-25H2,2-4H3,(H,50,51)/t27-,28+,31+,32-,35+,36-,37-,38+,39-,40+,43-,44-,45+,46-,47-,48?/m1/s1
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n/an/a>1n/an/an/an/an/an/a



Toho University

Curated by ChEMBL


Assay Description
Agonist activity at Protein kinase C in human MT4 cells infected with HIV-1 NL4-3 assessed as inhibition of viral replication measured on day 3 post-...


J Med Chem 62: 6958-6971 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00339
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50519067
PNG
(CHEMBL4443186)
Show SMILES C\C=C(/C)C(=O)O[C@@H]1CCCCCC[C@@H](C)[C@H]2[C@H](C)[C@H](OC(=O)c3ccccc3)[C@]3(O)[C@@H]2[C@]24OC11O[C@H]([C@@H]2[C@@H]2O[C@]2(CO)[C@H]3O)[C@](C[C@H]4COC(=O)c2ccccc2)(O1)C(C)=C
Show InChI InChI=1S/C49H60O13/c1-7-28(4)41(51)57-34-23-17-9-8-12-18-29(5)35-30(6)38(58-43(53)32-21-15-11-16-22-32)47(55)37(35)48-33(25-56-42(52)31-19-13-10-14-20-31)24-45(27(2)3)39(60-49(34,61-45)62-48)36(48)40-46(26-50,59-40)44(47)54/h7,10-11,13-16,19-22,29-30,33-40,44,50,54-55H,2,8-9,12,17-18,23-26H2,1,3-6H3/b28-7+/t29-,30+,33+,34-,35+,36-,37-,38+,39-,40+,44-,45-,46+,47-,48-,49?/m1/s1
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n/an/a>1n/an/an/an/an/an/a



Toho University

Curated by ChEMBL


Assay Description
Agonist activity at Protein kinase C in human MT4 cells infected with HIV-1 NL4-3 assessed as inhibition of viral replication measured on day 3 post-...


J Med Chem 62: 6958-6971 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00339
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50519070
PNG
(CHEMBL4580586)
Show SMILES C[C@@H]1[C@H](OC(=O)c2ccccc2)[C@]2(O)[C@H]3[C@H]1[C@H](C)CCCCCC[C@@H](O)C14O[C@@H]5[C@H]([C@@H]6O[C@]6(COC(C)=O)[C@H]2O)[C@]3(O1)[C@H](COC(=O)c1ccccc1)C[C@@]5(O4)C(C)=C
Show InChI InChI=1S/C46H56O13/c1-25(2)42-22-31(23-53-39(49)29-17-11-8-12-18-29)45-34-37(42)57-46(58-42,59-45)32(48)21-15-7-6-10-16-26(3)33-27(4)36(55-40(50)30-19-13-9-14-20-30)44(52,35(33)45)41(51)43(38(34)56-43)24-54-28(5)47/h8-9,11-14,17-20,26-27,31-38,41,48,51-52H,1,6-7,10,15-16,21-24H2,2-5H3/t26-,27+,31+,32-,33+,34-,35-,36+,37-,38+,41-,42-,43+,44-,45-,46?/m1/s1
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n/an/a>1n/an/an/an/an/an/a



Toho University

Curated by ChEMBL


Assay Description
Agonist activity at Protein kinase C in human MT4 cells infected with HIV-1 NL4-3 assessed as inhibition of viral replication measured on day 3 post-...


J Med Chem 62: 6958-6971 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00339
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50519071
PNG
(CHEMBL4585270)
Show SMILES COc1ccc(\C=C\C(=O)OC[C@]23O[C@H]2[C@H]2[C@H]4OC56O[C@]4(C[C@@H](COC(=O)c4ccccc4)[C@]2(O5)[C@@H]2[C@H]([C@H](C)[C@H](OC(=O)c4ccccc4)[C@@]2(O)[C@@H]3O)[C@H](C)CCCCCC[C@H]6O)C(C)=C)cc1
Show InChI InChI=1S/C54H62O14/c1-31(2)50-28-37(29-62-47(57)35-17-11-8-12-18-35)53-42-45(50)66-54(67-50,68-53)39(55)21-15-7-6-10-16-32(3)41-33(4)44(64-48(58)36-19-13-9-14-20-36)52(60,43(41)53)49(59)51(46(42)65-51)30-63-40(56)27-24-34-22-25-38(61-5)26-23-34/h8-9,11-14,17-20,22-27,32-33,37,39,41-46,49,55,59-60H,1,6-7,10,15-16,21,28-30H2,2-5H3/b27-24+/t32-,33+,37+,39-,41+,42-,43-,44+,45-,46+,49-,50-,51+,52-,53-,54?/m1/s1
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n/an/a>1n/an/an/an/an/an/a



Toho University

Curated by ChEMBL


Assay Description
Agonist activity at Protein kinase C in human MT4 cells infected with HIV-1 NL4-3 assessed as inhibition of viral replication measured on day 3 post-...


J Med Chem 62: 6958-6971 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00339
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50519072
PNG
(CHEMBL4580556)
Show SMILES C[C@@H]1[C@H](OC(=O)c2ccccc2)[C@]2(O)[C@H]3[C@H]1[C@H](C)CCCCCC[C@@H](OC(=O)c1ccc4ccccc4c1)C14O[C@@H]5[C@H]([C@@H]6O[C@]6(CO)[C@H]2O)[C@]3(O1)[C@H](COC(=O)c1ccccc1)C[C@@]5(O4)C(C)=C
Show InChI InChI=1S/C55H60O13/c1-31(2)51-28-39(29-62-47(57)35-19-10-7-11-20-35)54-42-45(51)66-55(67-51,68-54)40(63-49(59)38-26-25-34-18-15-16-23-37(34)27-38)24-14-6-5-9-17-32(3)41-33(4)44(64-48(58)36-21-12-8-13-22-36)53(61,43(41)54)50(60)52(30-56)46(42)65-52/h7-8,10-13,15-16,18-23,25-27,32-33,39-46,50,56,60-61H,1,5-6,9,14,17,24,28-30H2,2-4H3/t32-,33+,39+,40-,41+,42-,43-,44+,45-,46+,50-,51-,52+,53-,54-,55?/m1/s1
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n/an/a>1n/an/an/an/an/an/a



Toho University

Curated by ChEMBL


Assay Description
Agonist activity at Protein kinase C in human MT4 cells infected with HIV-1 NL4-3 assessed as inhibition of viral replication measured on day 3 post-...


J Med Chem 62: 6958-6971 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00339
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50519073
PNG
(CHEMBL4536366)
Show SMILES C[C@@H]1[C@H](OC(=O)c2ccccc2)[C@]2(O)[C@H]3[C@H]1[C@H](C)CCCCCC[C@@H](O)C14O[C@@H]5[C@H]([C@@H]6O[C@]6(COC(=O)C6(C)COC(C)(C)OC6)[C@H]2O)[C@]3(O1)[C@H](COC(=O)c1ccccc1)C[C@@]5(O4)C(C)=C
Show InChI InChI=1S/C52H66O15/c1-29(2)48-24-34(25-59-42(54)32-19-13-10-14-20-32)51-37-40(48)65-52(66-48,67-51)35(53)23-17-9-8-12-18-30(3)36-31(4)39(63-43(55)33-21-15-11-16-22-33)50(58,38(36)51)44(56)49(41(37)64-49)28-60-45(57)47(7)26-61-46(5,6)62-27-47/h10-11,13-16,19-22,30-31,34-41,44,53,56,58H,1,8-9,12,17-18,23-28H2,2-7H3/t30-,31+,34+,35-,36+,37-,38-,39+,40-,41+,44-,48-,49+,50-,51-,52?/m1/s1
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n/an/a>1n/an/an/an/an/an/a



Toho University

Curated by ChEMBL


Assay Description
Agonist activity at Protein kinase C in human MT4 cells infected with HIV-1 NL4-3 assessed as inhibition of viral replication measured on day 3 post-...


J Med Chem 62: 6958-6971 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00339
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50519074
PNG
(CHEMBL4442856)
Show SMILES C[C@@H]1[C@H](OC(=O)c2ccccc2)[C@]2(O)[C@H]3[C@H]1[C@H](C)CCCCCC[C@@H](OC(=O)\C=C\c1ccccc1)C14O[C@@H]5[C@H]([C@@H]6O[C@]6(CO)[C@H]2O)[C@]3(O1)[C@H](COC(=O)c1ccccc1)C[C@@]5(O4)C(C)=C
Show InChI InChI=1S/C53H60O13/c1-31(2)49-28-37(29-60-46(56)35-21-13-8-14-22-35)52-41-44(49)64-53(65-49,66-52)38(61-39(55)27-26-34-19-11-7-12-20-34)25-17-6-5-10-18-32(3)40-33(4)43(62-47(57)36-23-15-9-16-24-36)51(59,42(40)52)48(58)50(30-54)45(41)63-50/h7-9,11-16,19-24,26-27,32-33,37-38,40-45,48,54,58-59H,1,5-6,10,17-18,25,28-30H2,2-4H3/b27-26+/t32-,33+,37+,38-,40+,41-,42-,43+,44-,45+,48-,49-,50+,51-,52-,53?/m1/s1
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n/an/a>1n/an/an/an/an/an/a



Toho University

Curated by ChEMBL


Assay Description
Agonist activity at Protein kinase C in human MT4 cells infected with HIV-1 NL4-3 assessed as inhibition of viral replication measured on day 3 post-...


J Med Chem 62: 6958-6971 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00339
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50519075
PNG
(CHEMBL4558004)
Show SMILES C[C@@H]1[C@H](O)[C@]2(O)[C@H]3[C@H]1[C@H](C)CCCCCC[C@@H](O)C14O[C@@H]5[C@H]([C@@H]6O[C@]6(CO)[C@H]2O)[C@]3(O1)[C@H](COC(=O)c1ccccc1)C[C@@]5(O4)C(C)=C
Show InChI InChI=1S/C37H50O11/c1-19(2)33-16-23(17-44-31(41)22-13-9-7-10-14-22)36-26-29(33)46-37(47-33,48-36)24(39)15-11-6-5-8-12-20(3)25-21(4)28(40)35(43,27(25)36)32(42)34(18-38)30(26)45-34/h7,9-10,13-14,20-21,23-30,32,38-40,42-43H,1,5-6,8,11-12,15-18H2,2-4H3/t20-,21+,23+,24-,25+,26-,27-,28+,29-,30+,32-,33-,34+,35-,36-,37?/m1/s1
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n/an/a>1n/an/an/an/an/an/a



Toho University

Curated by ChEMBL


Assay Description
Agonist activity at Protein kinase C in human MT4 cells infected with HIV-1 NL4-3 assessed as inhibition of viral replication measured on day 3 post-...


J Med Chem 62: 6958-6971 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00339
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50519076
PNG
(CHEMBL4570883)
Show SMILES C[C@@H]1[C@H](OC(=O)c2ccccc2)[C@]2(O)[C@H]3[C@H]1[C@H](C)CCCCCC[C@@H](O)C14O[C@@H]5[C@H]([C@@H]6O[C@]6(COC(=O)[C@@]67CC[C@@](C)(C(=O)O6)C7(C)C)[C@H]2O)[C@]3(O1)[C@H](COC(=O)c1ccccc1)C[C@@]5(O4)C(C)=C
Show InChI InChI=1S/C54H66O15/c1-29(2)49-26-34(27-62-42(56)32-19-13-10-14-20-32)53-37-40(49)66-54(68-49,69-53)35(55)23-17-9-8-12-18-30(3)36-31(4)39(64-43(57)33-21-15-11-16-22-33)52(61,38(36)53)44(58)50(41(37)65-50)28-63-46(60)51-25-24-48(7,45(59)67-51)47(51,5)6/h10-11,13-16,19-22,30-31,34-41,44,55,58,61H,1,8-9,12,17-18,23-28H2,2-7H3/t30-,31+,34+,35-,36+,37-,38-,39+,40-,41+,44-,48+,49-,50+,51-,52-,53-,54?/m1/s1
PDB

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n/an/a>1n/an/an/an/an/an/a



Toho University

Curated by ChEMBL


Assay Description
Agonist activity at Protein kinase C in human MT4 cells infected with HIV-1 NL4-3 assessed as inhibition of viral replication measured on day 3 post-...


J Med Chem 62: 6958-6971 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00339
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50519077
PNG
(CHEMBL4470135)
Show SMILES C[C@@H]1[C@H](OC(=O)c2ccccc2)[C@]2(O)[C@H]3[C@H]1[C@H](C)CCCCCC[C@@H](O)C14O[C@@H]5[C@H]([C@@H]6O[C@]6(CO)[C@H]2OC(=O)c2ccccc2)[C@]3(O1)[C@H](COC(=O)c1ccccc1)C[C@@]5(O4)C(C)=C
Show InChI InChI=1S/C51H58O13/c1-29(2)47-26-35(27-58-43(54)32-19-11-7-12-20-32)50-38-41(47)62-51(63-47,64-50)36(53)25-17-6-5-10-18-30(3)37-31(4)40(59-44(55)33-21-13-8-14-22-33)49(57,39(37)50)46(48(28-52)42(38)61-48)60-45(56)34-23-15-9-16-24-34/h7-9,11-16,19-24,30-31,35-42,46,52-53,57H,1,5-6,10,17-18,25-28H2,2-4H3/t30-,31+,35+,36-,37+,38-,39-,40+,41-,42+,46-,47-,48+,49-,50-,51?/m1/s1
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n/an/a>1n/an/an/an/an/an/a



Toho University

Curated by ChEMBL


Assay Description
Agonist activity at Protein kinase C in human MT4 cells infected with HIV-1 NL4-3 assessed as inhibition of viral replication measured on day 3 post-...


J Med Chem 62: 6958-6971 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00339
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50519078
PNG
(CHEMBL4587134)
Show SMILES C[C@@H]1[C@H](OC(=O)c2ccccc2)[C@]2(O)[C@H]3[C@H]1[C@H](C)CCCCCC[C@@H](O)C14O[C@@H]5[C@H]([C@@H]6O[C@]6(COC(=O)CC(C)(C)C(O)=O)[C@H]2O)[C@]3(O1)[C@H](COC(=O)c1ccccc1)C[C@@]5(O4)C(C)=C
Show InChI InChI=1S/C50H62O15/c1-27(2)46-23-32(25-59-41(53)30-18-12-9-13-19-30)49-36-39(46)63-50(64-46,65-49)33(51)22-16-8-7-11-17-28(3)35-29(4)38(61-42(54)31-20-14-10-15-21-31)48(58,37(35)49)43(55)47(40(36)62-47)26-60-34(52)24-45(5,6)44(56)57/h9-10,12-15,18-21,28-29,32-33,35-40,43,51,55,58H,1,7-8,11,16-17,22-26H2,2-6H3,(H,56,57)/t28-,29+,32+,33-,35+,36-,37-,38+,39-,40+,43-,46-,47+,48-,49-,50?/m1/s1
PDB

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n/an/a>1n/an/an/an/an/an/a



Toho University

Curated by ChEMBL


Assay Description
Agonist activity at Protein kinase C in human MT4 cells infected with HIV-1 NL4-3 assessed as inhibition of viral replication measured on day 3 post-...


J Med Chem 62: 6958-6971 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00339
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50519079
PNG
(CHEMBL4451784)
Show SMILES COc1ccc(cc1)C(=O)O[C@@H]1CCCCCC[C@@H](C)[C@H]2[C@H](C)[C@H](OC(=O)c3ccccc3)[C@]3(O)[C@@H]2[C@]24OC11O[C@H]([C@@H]2[C@@H]2O[C@]2(CO)[C@H]3O)[C@](C[C@H]4COC(=O)c2ccccc2)(O1)C(C)=C
Show InChI InChI=1S/C52H60O14/c1-29(2)48-26-35(27-60-44(54)32-17-11-8-12-18-32)51-39-42(48)64-52(65-48,66-51)37(61-45(55)34-22-24-36(59-5)25-23-34)21-15-7-6-10-16-30(3)38-31(4)41(62-46(56)33-19-13-9-14-20-33)50(58,40(38)51)47(57)49(28-53)43(39)63-49/h8-9,11-14,17-20,22-25,30-31,35,37-43,47,53,57-58H,1,6-7,10,15-16,21,26-28H2,2-5H3/t30-,31+,35+,37-,38+,39-,40-,41+,42-,43+,47-,48-,49+,50-,51-,52?/m1/s1
PDB

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n/an/a>1n/an/an/an/an/an/a



Toho University

Curated by ChEMBL


Assay Description
Agonist activity at Protein kinase C in human MT4 cells infected with HIV-1 NL4-3 assessed as inhibition of viral replication measured on day 3 post-...


J Med Chem 62: 6958-6971 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00339
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50519080
PNG
(CHEMBL4562111)
Show SMILES C[C@@H]1[C@H](OC(=O)c2ccccc2)[C@]2(O)[C@H]3[C@H]1[C@H](C)CCCCCC[C@@H](OC(=O)c1ccccc1)C14O[C@@H]5[C@H]([C@@H]6O[C@]6(COC(=O)c6ccccc6)[C@H]2O)[C@]3(O1)[C@H](COC(=O)c1ccccc1)C[C@@]5(O4)C(C)=C
Show InChI InChI=1S/C58H62O14/c1-34(2)54-31-41(32-65-49(59)37-22-12-7-13-23-37)57-44-47(54)70-58(71-54,72-57)42(67-51(61)39-26-16-9-17-27-39)30-20-6-5-11-21-35(3)43-36(4)46(68-52(62)40-28-18-10-19-29-40)56(64,45(43)57)53(63)55(48(44)69-55)33-66-50(60)38-24-14-8-15-25-38/h7-10,12-19,22-29,35-36,41-48,53,63-64H,1,5-6,11,20-21,30-33H2,2-4H3/t35-,36+,41+,42-,43+,44-,45-,46+,47-,48+,53-,54-,55+,56-,57-,58?/m1/s1
PDB

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n/an/a>1n/an/an/an/an/an/a



Toho University

Curated by ChEMBL


Assay Description
Agonist activity at Protein kinase C in human MT4 cells infected with HIV-1 NL4-3 assessed as inhibition of viral replication measured on day 3 post-...


J Med Chem 62: 6958-6971 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00339
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50519081
PNG
(CHEMBL4537465)
Show SMILES C[C@@H]1[C@H](OC(=O)c2ccccc2)[C@]2(O)[C@H]3[C@H]1[C@H](C)CCCCCC[C@@H](OC(C)=O)C14O[C@@H]5[C@H]([C@@H]6O[C@]6(COC(C)=O)[C@H]2OC(C)=O)[C@]3(O1)[C@H](COC(=O)c1ccccc1)C[C@@]5(O4)C(C)=C
Show InChI InChI=1S/C50H60O15/c1-27(2)46-24-35(25-57-43(54)33-19-13-10-14-20-33)49-38-41(46)63-50(64-46,65-49)36(59-31(6)52)23-17-9-8-12-18-28(3)37-29(4)40(61-44(55)34-21-15-11-16-22-34)48(56,39(37)49)45(60-32(7)53)47(42(38)62-47)26-58-30(5)51/h10-11,13-16,19-22,28-29,35-42,45,56H,1,8-9,12,17-18,23-26H2,2-7H3/t28-,29+,35+,36-,37+,38-,39-,40+,41-,42+,45-,46-,47+,48-,49-,50?/m1/s1
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n/an/a>1n/an/an/an/an/an/a



Toho University

Curated by ChEMBL


Assay Description
Agonist activity at Protein kinase C in human MT4 cells infected with HIV-1 NL4-3 assessed as inhibition of viral replication measured on day 3 post-...


J Med Chem 62: 6958-6971 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00339
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50519082
PNG
(CHEMBL4527508)
Show SMILES C[C@@H]1[C@H](OC(=O)c2ccccc2)[C@]2(O)[C@H]3[C@H]1[C@H](C)CCCCCC[C@@H](O)C14O[C@@H]5[C@H]([C@@H]6O[C@]6(COC(=O)c6ccccc6)[C@H]2O)[C@]3(O1)[C@H](COC(=O)c1ccccc1)C[C@@]5(O4)C(C)=C
Show InChI InChI=1S/C51H58O13/c1-29(2)47-26-35(27-58-43(53)32-19-11-7-12-20-32)50-38-41(47)62-51(63-47,64-50)36(52)25-17-6-5-10-18-30(3)37-31(4)40(60-45(55)34-23-15-9-16-24-34)49(57,39(37)50)46(56)48(42(38)61-48)28-59-44(54)33-21-13-8-14-22-33/h7-9,11-16,19-24,30-31,35-42,46,52,56-57H,1,5-6,10,17-18,25-28H2,2-4H3/t30-,31+,35+,36-,37+,38-,39-,40+,41-,42+,46-,47-,48+,49-,50-,51?/m1/s1
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n/an/a>1n/an/an/an/an/an/a



Toho University

Curated by ChEMBL


Assay Description
Agonist activity at Protein kinase C in human MT4 cells infected with HIV-1 NL4-3 assessed as inhibition of viral replication measured on day 3 post-...


J Med Chem 62: 6958-6971 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00339
More data for this
Ligand-Target Pair
Protein kinase C (PKC)


(Homo sapiens (Human))
BDBM50519085
PNG
(CHEMBL4444766)
Show SMILES C[C@@H]1[C@H](OC(=O)c2ccccc2)[C@]2(O)[C@H]3[C@H]1[C@H](C)CCCCCC[C@@H](O)C14O[C@@H]5[C@H]([C@@H]6O[C@]6(CO)C2=O)[C@]3(O1)[C@H](COC(=O)c1ccccc1)C[C@@]5(O4)C(C)=C
Show InChI InChI=1S/C44H52O12/c1-24(2)40-21-29(22-51-37(47)27-16-10-7-11-17-27)43-32-35(40)54-44(55-40,56-43)30(46)20-14-6-5-9-15-25(3)31-26(4)34(52-38(48)28-18-12-8-13-19-28)42(50,33(31)43)39(49)41(23-45)36(32)53-41/h7-8,10-13,16-19,25-26,29-36,45-46,50H,1,5-6,9,14-15,20-23H2,2-4H3/t25-,26+,29+,30-,31+,32-,33-,34+,35-,36+,40-,41+,42-,43-,44?/m1/s1
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n/an/a>1n/an/an/an/an/an/a



Toho University

Curated by ChEMBL


Assay Description
Agonist activity at Protein kinase C in human MT4 cells infected with HIV-1 NL4-3 assessed as inhibition of viral replication measured on day 3 post-...


J Med Chem 62: 6958-6971 (2019)


Article DOI: 10.1021/acs.jmedchem.9b00339
More data for this
Ligand-Target Pair
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