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Compile Data Set for Download or QSAR

Found 351 hits of affinity data for UniProtKB/TrEMBL: G3H407   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121106
PNG
(US8722896, (-)-(3R)-1-(Indolin-4-ylmethyl)- N-(9-c...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)[C@@H]1CCN(Cc2cccc3NCCc23)C1
Show InChI InChI=1/C28H36ClN3O3/c1-19(2)15-32(16-20-13-24(29)27-26(14-20)34-11-4-12-35-27)28(33)22-8-10-31(18-22)17-21-5-3-6-25-23(21)7-9-30-25/h3,5-6,13-14,19,22,30H,4,7-12,15-18H2,1-2H3/t22-/s2
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US Patent
0.206 -57.5n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121324
PNG
(US8722896, (-)-(2R)-2-Methyl-3-((3- hydroxy)benzyl...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)[C@H](C)CNCc1cccc(O)c1
Show InChI InChI=1/C25H33ClN2O4/c1-17(2)15-28(16-20-11-22(26)24-23(12-20)31-8-5-9-32-24)25(30)18(3)13-27-14-19-6-4-7-21(29)10-19/h4,6-7,10-12,17-18,27,29H,5,8-9,13-16H2,1-3H3/t18-/s2
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US Patent
0.280 -56.7n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121105
PNG
(US8722896, (-)-(3R)-1-(Indol-7-ylmethyl)-N- (9-chl...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)[C@@H]1CCN(Cc2cccc3cc[nH]c23)C1
Show InChI InChI=1/C28H34ClN3O3/c1-19(2)15-32(16-20-13-24(29)27-25(14-20)34-11-4-12-35-27)28(33)23-8-10-31(18-23)17-22-6-3-5-21-7-9-30-26(21)22/h3,5-7,9,13-14,19,23,30H,4,8,10-12,15-18H2,1-2H3/t23-/s2
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US Patent
0.514 -55.2n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121086
PNG
(US8722896, (-)-(3R)-1-(3-Hydroxybenzyl)- N-(9-chlo...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)[C@@H]1CCN(Cc2cccc(O)c2)C1
Show InChI InChI=1/C26H33ClN2O4/c1-18(2)14-29(16-20-12-23(27)25-24(13-20)32-9-4-10-33-25)26(31)21-7-8-28(17-21)15-19-5-3-6-22(30)11-19/h3,5-6,11-13,18,21,30H,4,7-10,14-17H2,1-2H3/t21-/s2
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US Patent
0.550 -55.0n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121068
PNG
(US8722896, (-)-(3R)-1-(2-Methoxybenzyl)- N-(9-chlo...)
Show SMILES COc1ccccc1CN1CC[C@H](C1)C(=O)N(CC(C)C)Cc1cc(Cl)c2OCCCOc2c1
Show InChI InChI=1/C27H35ClN2O4/c1-19(2)15-30(16-20-13-23(28)26-25(14-20)33-11-6-12-34-26)27(31)22-9-10-29(18-22)17-21-7-4-5-8-24(21)32-3/h4-5,7-8,13-14,19,22H,6,9-12,15-18H2,1-3H3/t22-/s2
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US Patent
0.680 -54.4n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121116
PNG
(US8722896, (-)-(3R)-N-(9-chloro-3,4- dihydro-2H-1,...)
Show SMILES COc1ncccc1CN1CC[C@H](C1)C(=O)N(CC(C)C)Cc1cc(Cl)c2OCCCOc2c1
Show InChI InChI=1/C26H34ClN3O4/c1-18(2)14-30(15-19-12-22(27)24-23(13-19)33-10-5-11-34-24)26(31)21-7-9-29(17-21)16-20-6-4-8-28-25(20)32-3/h4,6,8,12-13,18,21H,5,7,9-11,14-17H2,1-3H3/t21-/s2
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US Patent
0.710 -54.3n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121040
PNG
(US8722896, (+/-)-2-Methyl-3-((2- methoxy)benzylami...)
Show SMILES COc1ccccc1CNCC(C)C(=O)N(CC(C)C)Cc1cc(Cl)c2OCCCOc2c1
Show InChI InChI=1/C26H35ClN2O4/c1-18(2)16-29(17-20-12-22(27)25-24(13-20)32-10-7-11-33-25)26(30)19(3)14-28-15-21-8-5-6-9-23(21)31-4/h5-6,8-9,12-13,18-19,28H,7,10-11,14-17H2,1-4H3
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US Patent
0.720 -54.3n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121070
PNG
(US8722896, (-)-(3R)-1-(2-Methoxybenzyl)- N-(9-fluo...)
Show SMILES COc1ccccc1CN1CC[C@H](C1)C(=O)N(CC(C)C)Cc1cc(F)c2OCCCOc2c1
Show InChI InChI=1/C27H35FN2O4/c1-19(2)15-30(16-20-13-23(28)26-25(14-20)33-11-6-12-34-26)27(31)22-9-10-29(18-22)17-21-7-4-5-8-24(21)32-3/h4-5,7-8,13-14,19,22H,6,9-12,15-18H2,1-3H3/t22-/s2
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US Patent
0.810 -54.0n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121319
PNG
(US8722896, (+/-)-2-Methyl-3-((3- acetoxy)benzylami...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C(C)CNCc1cccc(OC(C)=O)c1
Show InChI InChI=1/C27H35ClN2O5/c1-18(2)16-30(17-22-12-24(28)26-25(13-22)33-9-6-10-34-26)27(32)19(3)14-29-15-21-7-5-8-23(11-21)35-20(4)31/h5,7-8,11-13,18-19,29H,6,9-10,14-17H2,1-4H3
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US Patent
0.890 -53.7n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121324
PNG
(US8722896, (-)-(2R)-2-Methyl-3-((3- hydroxy)benzyl...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)[C@H](C)CNCc1cccc(O)c1
Show InChI InChI=1/C25H33ClN2O4/c1-17(2)15-28(16-20-11-22(26)24-23(12-20)31-8-5-9-32-24)25(30)18(3)13-27-14-19-6-4-7-21(29)10-19/h4,6-7,10-12,17-18,27,29H,5,8-9,13-16H2,1-3H3/t18-/s2
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US Patent
0.930 -53.6n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121088
PNG
(US8722896, (-)-(3R)-1-(3-Methoxybenzyl)- N-(9-chlo...)
Show SMILES COc1cccc(CN2CC[C@H](C2)C(=O)N(CC(C)C)Cc2cc(Cl)c3OCCCOc3c2)c1
Show InChI InChI=1/C27H35ClN2O4/c1-19(2)15-30(17-21-13-24(28)26-25(14-21)33-10-5-11-34-26)27(31)22-8-9-29(18-22)16-20-6-4-7-23(12-20)32-3/h4,6-7,12-14,19,22H,5,8-11,15-18H2,1-3H3/t22-/s2
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US Patent
1.03 -53.4n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121156
PNG
(US8722896, (+/-)-2-Methyl-3-(1-((2- methoxypyridin...)
Show SMILES COc1ncccc1CNCC(C)C(=O)N(CC(C)C)Cc1cc(Cl)c2OCCCOc2c1
Show InChI InChI=1/C25H34ClN3O4/c1-17(2)15-29(16-19-11-21(26)23-22(12-19)32-9-6-10-33-23)25(30)18(3)13-27-14-20-7-5-8-28-24(20)31-4/h5,7-8,11-12,17-18,27H,6,9-10,13-16H2,1-4H3
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US Patent
1.06 -53.3n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121261
PNG
(US8722896, (-)-(3R)-1-(N-methyl-indol-4- ylmethyl)...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C1CCCN(Cc2cccc3n(C)ccc23)C1
Show InChI InChI=1/C30H38ClN3O3/c1-21(2)17-34(18-22-15-26(31)29-28(16-22)36-13-6-14-37-29)30(35)24-8-5-11-33(20-24)19-23-7-4-9-27-25(23)10-12-32(27)3/h4,7,9-10,12,15-16,21,24H,5-6,8,11,13-14,17-20H2,1-3H3
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US Patent
1.24 -52.9n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121040
PNG
(US8722896, (+/-)-2-Methyl-3-((2- methoxy)benzylami...)
Show SMILES COc1ccccc1CNCC(C)C(=O)N(CC(C)C)Cc1cc(Cl)c2OCCCOc2c1
Show InChI InChI=1/C26H35ClN2O4/c1-18(2)16-29(17-20-12-22(27)25-24(13-20)32-10-7-11-33-25)26(30)19(3)14-28-15-21-8-5-6-9-23(21)31-4/h5-6,8-9,12-13,18-19,28H,7,10-11,14-17H2,1-4H3
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US Patent
1.35 -52.7n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121253
PNG
(US8722896, (-)-(2R)-2-Methyl-3-(indol-7- ylmethyla...)
Show SMILES CC(C)CN(Cc1cnc2OCCCOc2c1)C(=O)C(C)CNCc1cccc2cc[nH]c12
Show InChI InChI=1/C26H34N4O3/c1-18(2)16-30(17-20-12-23-25(29-14-20)33-11-5-10-32-23)26(31)19(3)13-27-15-22-7-4-6-21-8-9-28-24(21)22/h4,6-9,12,14,18-19,27-28H,5,10-11,13,15-17H2,1-3H3
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US Patent
1.39 -52.6n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121042
PNG
(US8722896, (+)-(2S)-2-Methyl-3- benzylmethylamino)...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C(C)CNCc1ccccc1
Show InChI InChI=1/C25H33ClN2O3/c1-18(2)16-28(25(29)19(3)14-27-15-20-8-5-4-6-9-20)17-21-12-22(26)24-23(13-21)30-10-7-11-31-24/h4-6,8-9,12-13,18-19,27H,7,10-11,14-17H2,1-3H3
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US Patent
1.40 -52.6n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121202
PNG
(US8722896, (+)-(2S)-2-Methyl-3-(indol-4- ylmethyla...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C(C)CNCc1cccc2[nH]ccc12
Show InChI InChI=1/C27H34ClN3O3/c1-18(2)16-31(17-20-12-23(28)26-25(13-20)33-10-5-11-34-26)27(32)19(3)14-29-15-21-6-4-7-24-22(21)8-9-30-24/h4,6-9,12-13,18-19,29-30H,5,10-11,14-17H2,1-3H3
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US Patent
1.43 -52.5n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121202
PNG
(US8722896, (+)-(2S)-2-Methyl-3-(indol-4- ylmethyla...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C(C)CNCc1cccc2[nH]ccc12
Show InChI InChI=1/C27H34ClN3O3/c1-18(2)16-31(17-20-12-23(28)26-25(13-20)33-10-5-11-34-26)27(32)19(3)14-29-15-21-6-4-7-24-22(21)8-9-30-24/h4,6-9,12-13,18-19,29-30H,5,10-11,14-17H2,1-3H3
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US Patent
1.5 -52.4n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121231
PNG
(US8722896, (+/-)-(3R)-2-Methyl-3-(indolin-4- ylmet...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C(C)CNCc1cccc2NCCc12
Show InChI InChI=1/C27H36ClN3O3/c1-18(2)16-31(17-20-12-23(28)26-25(13-20)33-10-5-11-34-26)27(32)19(3)14-29-15-21-6-4-7-24-22(21)8-9-30-24/h4,6-7,12-13,18-19,29-30H,5,8-11,14-17H2,1-3H3
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US Patent
1.53 -52.3n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121202
PNG
(US8722896, (+)-(2S)-2-Methyl-3-(indol-4- ylmethyla...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C(C)CNCc1cccc2[nH]ccc12
Show InChI InChI=1/C27H34ClN3O3/c1-18(2)16-31(17-20-12-23(28)26-25(13-20)33-10-5-11-34-26)27(32)19(3)14-29-15-21-6-4-7-24-22(21)8-9-30-24/h4,6-9,12-13,18-19,29-30H,5,10-11,14-17H2,1-3H3
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US Patent
1.60 -52.2n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121143
PNG
(US8722896, (+/-)-2-Methyl-3-((2- hydroxybenzyl)met...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C(C)CNCc1cccc(O)c1
Show InChI InChI=1/C25H33ClN2O4/c1-17(2)15-28(16-20-11-22(26)24-23(12-20)31-8-5-9-32-24)25(30)18(3)13-27-14-19-6-4-7-21(29)10-19/h4,6-7,10-12,17-18,27,29H,5,8-9,13-16H2,1-3H3
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US Patent
1.62 -52.2n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121041
PNG
(US8722896, (-)-(2R)-2-Methyl-3-((4- fluoro)benzyla...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C(C)CNCc1ccc(F)cc1
Show InChI InChI=1/C25H32ClFN2O3/c1-17(2)15-29(16-20-11-22(26)24-23(12-20)31-9-4-10-32-24)25(30)18(3)13-28-14-19-5-7-21(27)8-6-19/h5-8,11-12,17-18,28H,4,9-10,13-16H2,1-3H3
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US Patent
1.62 -52.2n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121070
PNG
(US8722896, (-)-(3R)-1-(2-Methoxybenzyl)- N-(9-fluo...)
Show SMILES COc1ccccc1CN1CC[C@H](C1)C(=O)N(CC(C)C)Cc1cc(F)c2OCCCOc2c1
Show InChI InChI=1/C27H35FN2O4/c1-19(2)15-30(16-20-13-23(28)26-25(14-20)33-11-6-12-34-26)27(31)22-9-10-29(18-22)17-21-7-4-5-8-24(21)32-3/h4-5,7-8,13-14,19,22H,6,9-12,15-18H2,1-3H3/t22-/s2
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US Patent
1.70 -52.1n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121086
PNG
(US8722896, (-)-(3R)-1-(3-Hydroxybenzyl)- N-(9-chlo...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)[C@@H]1CCN(Cc2cccc(O)c2)C1
Show InChI InChI=1/C26H33ClN2O4/c1-18(2)14-29(16-20-12-23(27)25-24(13-20)32-9-4-10-33-25)26(31)21-7-8-28(17-21)15-19-5-3-6-22(30)11-19/h3,5-6,11-13,18,21,30H,4,7-10,14-17H2,1-2H3/t21-/s2
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US Patent
1.76 -52.0n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121145
PNG
(US8722896, (+/-)-2-Methyl-3-((2- methoxybenzyl)met...)
Show SMILES COc1cccc(CNCC(C)C(=O)N(CC(C)C)Cc2cc(Cl)c3OCCCOc3c2)c1
Show InChI InChI=1/C26H35ClN2O4/c1-18(2)16-29(17-21-12-23(27)25-24(13-21)32-9-6-10-33-25)26(30)19(3)14-28-15-20-7-5-8-22(11-20)31-4/h5,7-8,11-13,18-19,28H,6,9-10,14-17H2,1-4H3
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US Patent
1.76 -52.0n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121143
PNG
(US8722896, (+/-)-2-Methyl-3-((2- hydroxybenzyl)met...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C(C)CNCc1cccc(O)c1
Show InChI InChI=1/C25H33ClN2O4/c1-17(2)15-28(16-20-11-22(26)24-23(12-20)31-8-5-9-32-24)25(30)18(3)13-27-14-19-6-4-7-21(29)10-19/h4,6-7,10-12,17-18,27,29H,5,8-9,13-16H2,1-3H3
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US Patent
1.77 -52.0n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121156
PNG
(US8722896, (+/-)-2-Methyl-3-(1-((2- methoxypyridin...)
Show SMILES COc1ncccc1CNCC(C)C(=O)N(CC(C)C)Cc1cc(Cl)c2OCCCOc2c1
Show InChI InChI=1/C25H34ClN3O4/c1-17(2)15-29(16-19-11-21(26)23-22(12-19)32-9-6-10-33-23)25(30)18(3)13-27-14-20-7-5-8-28-24(20)31-4/h5,7-8,11-12,17-18,27H,6,9-10,13-16H2,1-4H3
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US Patent
1.82 -51.9n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121205
PNG
(US8722896, (+)-(2S)-2-Methyl-3-(indol-7- ylmethyla...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C(C)CNCc1cccc2cc[nH]c12
Show InChI InChI=1/C27H34ClN3O3/c1-18(2)16-31(17-20-12-23(28)26-24(13-20)33-10-5-11-34-26)27(32)19(3)14-29-15-22-7-4-6-21-8-9-30-25(21)22/h4,6-9,12-13,18-19,29-30H,5,10-11,14-17H2,1-3H3
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US Patent
1.85 -51.9n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121307
PNG
(US8722896, (-)-(3R)-1-(Indolin-4-ylmethyl)- N-(9-c...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCCc2c1)C(=O)C1CCN(Cc2cccc3NCCc23)C1
Show InChI InChI=1/C29H38ClN3O2/c1-20(2)16-33(17-21-14-22-6-3-4-13-35-28(22)26(30)15-21)29(34)24-10-12-32(19-24)18-23-7-5-8-27-25(23)9-11-31-27/h5,7-8,14-15,20,24,31H,3-4,6,9-13,16-19H2,1-2H3
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US Patent
1.86 -51.8n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121053
PNG
(US8722896, (-)-(3R)-1-(2,3- Dimethylbenzyl)-N-(9-c...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C1CCN(Cc2cccc(C)c2C)C1
Show InChI InChI=1/C28H37ClN2O3/c1-19(2)15-31(16-22-13-25(29)27-26(14-22)33-11-6-12-34-27)28(32)24-9-10-30(18-24)17-23-8-5-7-20(3)21(23)4/h5,7-8,13-14,19,24H,6,9-12,15-18H2,1-4H3
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US Patent
1.89 -51.8n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121290
PNG
(US8722896, (+/-)-(3R)-4-(Indol-7-ylmethyl)- N-(9-c...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCCc2c1)C(=O)C1CN(Cc2cccc3cc[nH]c23)CCO1
Show InChI InChI=1/C29H36ClN3O3/c1-20(2)16-33(17-21-14-23-6-3-4-12-36-28(23)25(30)15-21)29(34)26-19-32(11-13-35-26)18-24-8-5-7-22-9-10-31-27(22)24/h5,7-10,14-15,20,26,31H,3-4,6,11-13,16-19H2,1-2H3
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US Patent
1.94 -51.7n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121262
PNG
(US8722896, (-)-(3R)-1-(Indolin-4-ylmethyl)- N-(9-c...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C1CCCN(Cc2cccc3NCCc23)C1
Show InChI InChI=1/C29H38ClN3O3/c1-20(2)16-33(17-21-14-25(30)28-27(15-21)35-12-5-13-36-28)29(34)23-7-4-11-32(19-23)18-22-6-3-8-26-24(22)9-10-31-26/h3,6,8,14-15,20,23,31H,4-5,7,9-13,16-19H2,1-2H3
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US Patent
2.22 -51.4n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121157
PNG
(US8722896, (+/-)-2-Methyl-3-(2,3-dihydro-1- benzof...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C(C)CNCc1cccc2CCOc12
Show InChI InChI=1/C27H35ClN2O4/c1-18(2)16-30(17-20-12-23(28)26-24(13-20)32-9-5-10-33-26)27(31)19(3)14-29-15-22-7-4-6-21-8-11-34-25(21)22/h4,6-7,12-13,18-19,29H,5,8-11,14-17H2,1-3H3
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US Patent
2.28 -51.3n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121157
PNG
(US8722896, (+/-)-2-Methyl-3-(2,3-dihydro-1- benzof...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C(C)CNCc1cccc2CCOc12
Show InChI InChI=1/C27H35ClN2O4/c1-18(2)16-30(17-20-12-23(28)26-24(13-20)32-9-5-10-33-26)27(31)19(3)14-29-15-22-7-4-6-21-8-11-34-25(21)22/h4,6-7,12-13,18-19,29H,5,8-11,14-17H2,1-3H3
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US Patent
2.38 -51.2n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121157
PNG
(US8722896, (+/-)-2-Methyl-3-(2,3-dihydro-1- benzof...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C(C)CNCc1cccc2CCOc12
Show InChI InChI=1/C27H35ClN2O4/c1-18(2)16-30(17-20-12-23(28)26-24(13-20)32-9-5-10-33-26)27(31)19(3)14-29-15-22-7-4-6-21-8-11-34-25(21)22/h4,6-7,12-13,18-19,29H,5,8-11,14-17H2,1-3H3
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US Patent
2.38 -51.2n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121291
PNG
(US8722896, (+/-)-(3R)-4-(N-methyl-indol-4- ylmethy...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCCc2c1)C(=O)C1CN(Cc2cccc3n(C)ccc23)CCO1
Show InChI InChI=1/C30H38ClN3O3/c1-21(2)17-34(18-22-15-23-7-4-5-13-37-29(23)26(31)16-22)30(35)28-20-33(12-14-36-28)19-24-8-6-9-27-25(24)10-11-32(27)3/h6,8-11,15-16,21,28H,4-5,7,12-14,17-20H2,1-3H3
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US Patent
2.5 -51.1n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121104
PNG
(US8722896, (-)-(3R)-1-(Indol-4-ylmethyl)-N- (9-chl...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)[C@@H]1CCN(Cc2cccc3[nH]ccc23)C1
Show InChI InChI=1/C28H34ClN3O3/c1-19(2)15-32(16-20-13-24(29)27-26(14-20)34-11-4-12-35-27)28(33)22-8-10-31(18-22)17-21-5-3-6-25-23(21)7-9-30-25/h3,5-7,9,13-14,19,22,30H,4,8,10-12,15-18H2,1-2H3/t22-/s2
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US Patent
2.5 -51.1n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121275
PNG
(US8722896, (+/-)-4-(Indol-4-ylmethyl)-N-(9- chloro...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C1CN(Cc2cccc3[nH]ccc23)CCO1
Show InChI InChI=1/C28H34ClN3O4/c1-19(2)15-32(16-20-13-23(29)27-25(14-20)34-10-4-11-36-27)28(33)26-18-31(9-12-35-26)17-21-5-3-6-24-22(21)7-8-30-24/h3,5-8,13-14,19,26,30H,4,9-12,15-18H2,1-2H3
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US Patent
2.60 -51.0n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121202
PNG
(US8722896, (+)-(2S)-2-Methyl-3-(indol-4- ylmethyla...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C(C)CNCc1cccc2[nH]ccc12
Show InChI InChI=1/C27H34ClN3O3/c1-18(2)16-31(17-20-12-23(28)26-25(13-20)33-10-5-11-34-26)27(32)19(3)14-29-15-21-6-4-7-24-22(21)8-9-30-24/h4,6-9,12-13,18-19,29-30H,5,10-11,14-17H2,1-3H3
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US Patent
2.62 -51.0n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121259
PNG
(US8722896, (-)-(3R)-1-(Indolin-7-ylmethyl)- N-(9-c...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C1CCCN(Cc2cccc3CCNc23)C1
Show InChI InChI=1/C29H38ClN3O3/c1-20(2)16-33(17-21-14-25(30)28-26(15-21)35-12-5-13-36-28)29(34)24-8-4-11-32(19-24)18-23-7-3-6-22-9-10-31-27(22)23/h3,6-7,14-15,20,24,31H,4-5,8-13,16-19H2,1-2H3
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US Patent
2.62 -51.0n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121277
PNG
(US8722896, (+/-)-4-(Indolin-4-ylmethyl)-N-(9- chlo...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C1CN(Cc2cccc3NCCc23)CCO1
Show InChI InChI=1/C28H36ClN3O4/c1-19(2)15-32(16-20-13-23(29)27-25(14-20)34-10-4-11-36-27)28(33)26-18-31(9-12-35-26)17-21-5-3-6-24-22(21)7-8-30-24/h3,5-6,13-14,19,26,30H,4,7-12,15-18H2,1-2H3
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US Patent
2.64 -50.9n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121111
PNG
(US8722896, (-)-(3R)-1-Benzyl-N-(9-chloro- 3,4-dihy...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)[C@@H]1CCN(Cc2ccccc2)C1
Show InChI InChI=1/C26H33ClN2O3/c1-19(2)15-29(17-21-13-23(27)25-24(14-21)31-11-6-12-32-25)26(30)22-9-10-28(18-22)16-20-7-4-3-5-8-20/h3-5,7-8,13-14,19,22H,6,9-12,15-18H2,1-2H3/t22-/s2
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US Patent
2.66 -50.9n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121066
PNG
(US8722896, (-)-(3R)-1-(2-Methoxybenzyl)- N-(3,4-di...)
Show SMILES COc1ccccc1CN1CC[C@H](C1)C(=O)N(CC(C)C)Cc1ccc2OCCCOc2c1
Show InChI InChI=1/C27H36N2O4/c1-20(2)16-29(17-21-9-10-25-26(15-21)33-14-6-13-32-25)27(30)23-11-12-28(19-23)18-22-7-4-5-8-24(22)31-3/h4-5,7-10,15,20,23H,6,11-14,16-19H2,1-3H3/t23-/s2
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US Patent
2.67 -50.9n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121107
PNG
(US8722896, (-)-(3R)-1-(Indolin-7-ylmethyl)- N-(9-c...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)[C@@H]1CCN(Cc2cccc3CCNc23)C1
Show InChI InChI=1/C28H36ClN3O3/c1-19(2)15-32(16-20-13-24(29)27-25(14-20)34-11-4-12-35-27)28(33)23-8-10-31(18-23)17-22-6-3-5-21-7-9-30-26(21)22/h3,5-6,13-14,19,23,30H,4,7-12,15-18H2,1-2H3/t23-/s2
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US Patent
2.87 -50.7n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121205
PNG
(US8722896, (+)-(2S)-2-Methyl-3-(indol-7- ylmethyla...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C(C)CNCc1cccc2cc[nH]c12
Show InChI InChI=1/C27H34ClN3O3/c1-18(2)16-31(17-20-12-23(28)26-24(13-20)33-10-5-11-34-26)27(32)19(3)14-29-15-22-7-4-6-21-8-9-30-25(21)22/h4,6-9,12-13,18-19,29-30H,5,10-11,14-17H2,1-3H3
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US Patent
2.87 -50.7n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121047
PNG
(US8722896, (-)-(3R)-1-(1-Methyl-indol-4- ylmethyl)...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C1CCN(Cc2cccc3N(C)CCc23)C1
Show InChI InChI=1/C29H38ClN3O3/c1-20(2)16-33(17-21-14-25(30)28-27(15-21)35-12-5-13-36-28)29(34)23-8-11-32(19-23)18-22-6-4-7-26-24(22)9-10-31(26)3/h4,6-7,14-15,20,23H,5,8-13,16-19H2,1-3H3
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US Patent
2.92 -50.7n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121301
PNG
(US8722896, (-)-(3R)-1-(N-methyl-indol-7- ylmethyl)...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCCc2c1)C(=O)C1CCCN(Cc2cccc3ccn(C)c23)C1
Show InChI InChI=1/C31H40ClN3O2/c1-22(2)18-35(19-23-16-25-8-4-5-15-37-30(25)28(32)17-23)31(36)27-11-7-13-34(21-27)20-26-10-6-9-24-12-14-33(3)29(24)26/h6,9-10,12,14,16-17,22,27H,4-5,7-8,11,13,15,18-21H2,1-3H3
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US Patent
3 -50.6n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121270
PNG
(US8722896, (-)-(3R)-1-(3-Hydroxybenzyl)- N-(9-chlo...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C1CCCN(Cc2cccc(O)c2)C1
Show InChI InChI=1/C27H35ClN2O4/c1-19(2)15-30(17-21-13-24(28)26-25(14-21)33-10-5-11-34-26)27(32)22-7-4-9-29(18-22)16-20-6-3-8-23(31)12-20/h3,6,8,12-14,19,22,31H,4-5,7,9-11,15-18H2,1-2H3
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US Patent
3.02 -50.6n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121281
PNG
(US8722896, (+/-)-4-(2,3-Dihydro-1- benzofuran-7-yl...)
Show SMILES CC(C)CN(Cc1cc(Cl)c2OCCCOc2c1)C(=O)C1CN(Cc2cccc3CCOc23)CCO1
Show InChI InChI=1/C28H35ClN2O5/c1-19(2)15-31(16-20-13-23(29)27-24(14-20)33-9-4-10-35-27)28(32)25-18-30(8-12-34-25)17-22-6-3-5-21-7-11-36-26(21)22/h3,5-6,13-14,19,25H,4,7-12,15-18H2,1-2H3
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US Patent
3.10 -50.5n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
Prokineticin receptor 2 (PRK2)


(Cricetulus griseus (Chinese hamster))
BDBM121066
PNG
(US8722896, (-)-(3R)-1-(2-Methoxybenzyl)- N-(3,4-di...)
Show SMILES COc1ccccc1CN1CC[C@H](C1)C(=O)N(CC(C)C)Cc1ccc2OCCCOc2c1
Show InChI InChI=1/C27H36N2O4/c1-20(2)16-29(17-21-9-10-25-26(15-21)33-14-6-13-32-25)27(30)23-11-12-28(19-23)18-22-7-4-5-8-24(22)31-3/h4-5,7-10,15,20,23H,6,11-14,16-19H2,1-3H3/t23-/s2
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US Patent
3.18 -50.5n/an/an/an/an/an/a37



The Regents of the University of California

US Patent


Assay Description
An aequorin-based luminescent assay for calcium mobilization was used to measure mobilization of intracellular Ca2+ (Bullock et al., Mol Pharmacol 65...


US Patent US8722896 (2014)


BindingDB Entry DOI: 10.7270/Q29G5KGF
More data for this
Ligand-Target Pair
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