Found 2123 hits of ki for UniProtKB: P43140 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Alpha-1A adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM29568
 (CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccco1 Show InChI InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22) | Reactome pathway KEGG
UniProtKB/SwissProt
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CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem
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| PubMed
| 0.0100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
UnWersity of Misscuri
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 241: 875-81 (1987)
BindingDB Entry DOI: 10.7270/Q29885JF |
More data for this Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM29568
 (CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccco1 Show InChI InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22) | Reactome pathway KEGG
UniProtKB/SwissProt
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CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem
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| PubMed
| 0.0200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
UnWersity of Misscuri
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 241: 875-81 (1987)
BindingDB Entry DOI: 10.7270/Q29885JF |
More data for this Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50060964
 ((R)-5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-...)Show SMILES CCOc1ccccc1OCCN[C@H](C)Cc1ccc(OC)c(c1)S(N)(=O)=O Show InChI InChI=1S/C20H28N2O5S/c1-4-26-17-7-5-6-8-18(17)27-12-11-22-15(2)13-16-9-10-19(25-3)20(14-16)28(21,23)24/h5-10,14-15,22H,4,11-13H2,1-3H3,(H2,21,23,24)/t15-/m1/s1 | Reactome pathway KEGG
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| Article PubMed
| 0.0300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description In vitro binding affinity using [3H]-prazosin as radioligand against adrenoceptor alpha 1A |
J Med Chem 43: 1586-603 (2000)
Article DOI: 10.1021/jm990567u BindingDB Entry DOI: 10.7270/Q29C6WNR |
More data for this Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50100210
 (6-Methoxy-3-[2-(6-methoxy-1,3,3a,4,5,9b-hexahydro-...)Show SMILES COc1cc2[nH]c(=O)n(CCN3C[C@@H]4CCc5c(OC)cccc5[C@@H]4C3)c(=O)c2s1 Show InChI InChI=1S/C22H25N3O4S/c1-28-18-5-3-4-14-15(18)7-6-13-11-24(12-16(13)14)8-9-25-21(26)20-17(23-22(25)27)10-19(29-2)30-20/h3-5,10,13,16H,6-9,11-12H2,1-2H3,(H,23,27)/t13-,16+/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
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| CHEMBL PC cid PC sid UniChem
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| Article PubMed
| 0.0400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity to alpha-1A adrenergic receptor in rat submaxillary gland |
J Med Chem 44: 1971-85 (2001)
Article DOI: 10.1021/jm000541z BindingDB Entry DOI: 10.7270/Q2KP81GH |
More data for this Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50100221
 (7,8-Dimethoxy-3-[2-(6-methoxy-1,3,3a,4,5,9b-hexahy...)Show SMILES COc1cccc2[C@@H]3CN(CCn4c(=O)[nH]c5c(OC)c(OC)ccc5c4=O)C[C@@H]3CCc12 Show InChI InChI=1S/C25H29N3O5/c1-31-20-6-4-5-16-17(20)8-7-15-13-27(14-19(15)16)11-12-28-24(29)18-9-10-21(32-2)23(33-3)22(18)26-25(28)30/h4-6,9-10,15,19H,7-8,11-14H2,1-3H3,(H,26,30)/t15-,19+/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.0400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity to alpha-1A adrenergic receptor in rat submaxillary gland |
J Med Chem 44: 1971-85 (2001)
Article DOI: 10.1021/jm000541z BindingDB Entry DOI: 10.7270/Q2KP81GH |
More data for this Ligand-Target Pair | |
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50122243
 (4-Chloro-5-[4-(furan-2-carbonyl)-piperazin-1-yl]-2...)Show SMILES CC(C)Oc1ccccc1N1CCN(CCCCCCCn2ncc(N3CCN(CC3)C(=O)c3ccco3)c(Cl)c2=O)CC1 Show InChI InChI=1S/C33H45ClN6O4/c1-26(2)44-29-12-7-6-11-27(29)37-18-16-36(17-19-37)14-8-4-3-5-9-15-40-33(42)31(34)28(25-35-40)38-20-22-39(23-21-38)32(41)30-13-10-24-43-30/h6-7,10-13,24-26H,3-5,8-9,14-23H2,1-2H3 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.0520 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Pisa
Curated by ChEMBL
| Assay Description Binding affinity towards Alpha-1 adrenergic receptor in rat cerebral cortex using [3H]prazosin |
Bioorg Med Chem Lett 13: 171-3 (2002)
Article DOI: 10.1016/s0960-894x(02)00932-0 BindingDB Entry DOI: 10.7270/Q2TM79GX |
More data for this Ligand-Target Pair | |
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50230846
 (CHEMBL2114071)Show SMILES CN1C(=O)N2C(CN3CCN(CC3)c3ccccc3Cl)CN=C2c2ccccc12 Show InChI InChI=1S/C22H24ClN5O/c1-25-19-8-4-2-6-17(19)21-24-14-16(28(21)22(25)29)15-26-10-12-27(13-11-26)20-9-5-3-7-18(20)23/h2-9,16H,10-15H2,1H3 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 0.0680 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Defense Medical Center
Curated by ChEMBL
| Assay Description Binding affinity against alpha-1 adrenergic receptor by measuring displacement of [3H]prazosin from rat brain cortex membranes (in vitro). |
J Med Chem 36: 2196-207 (1993)
Article DOI: 10.1021/jm00067a017 BindingDB Entry DOI: 10.7270/Q298896M |
More data for this Ligand-Target Pair | |
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50230859
 (CHEMBL309150)Show SMILES COC1=Nc2ccccc2C2=NC(CN3CCN(CC3)c3ccccc3OC)CN12 Show InChI InChI=1S/C23H27N5O2/c1-29-21-10-6-5-9-20(21)27-13-11-26(12-14-27)15-17-16-28-22(24-17)18-7-3-4-8-19(18)25-23(28)30-2/h3-10,17H,11-16H2,1-2H3 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.0700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Defense Medical Center
Curated by ChEMBL
| Assay Description Binding affinity against alpha-1 adrenergic receptor by measuring displacement of [3H]prazosin from rat brain cortex membranes (in vitro). |
J Med Chem 36: 2196-207 (1993)
Article DOI: 10.1021/jm00067a017 BindingDB Entry DOI: 10.7270/Q298896M |
More data for this Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM29568
 (CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccco1 Show InChI InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22) | Reactome pathway KEGG
UniProtKB/SwissProt
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| 0.0700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Duke University
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 272: 134-42 (1995)
BindingDB Entry DOI: 10.7270/Q2ZC81CG |
More data for this Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM29568
 (CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccco1 Show InChI InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22) | Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| 0.0700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company
Curated by ChEMBL
| Assay Description Inhibition of [3H]- prazosin binding against Alpha-1A adrenergic receptor from rat submaxillary gland |
J Med Chem 42: 5181-7 (2000)
Article DOI: 10.1021/jm990277d BindingDB Entry DOI: 10.7270/Q23T9HZ0 |
More data for this Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM69602
 (2,3-dihydro-1,4-benzodioxin-3-ylmethyl-[2-(2,6-dim...)Show InChI InChI=1S/C19H23NO5/c1-21-17-8-5-9-18(22-2)19(17)23-11-10-20-12-14-13-24-15-6-3-4-7-16(15)25-14/h3-9,14,20H,10-13H2,1-2H3 | Reactome pathway KEGG
UniProtKB/SwissProt
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CHEBI CHEMBL PC cid PC sid UniChem
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| Article PubMed
| 0.0800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
SmithKline Beecham Pharmaceuticals Ltd
Curated by ChEMBL
| Assay Description Overall binding displacement in tissues containing only the Alpha-1A adrenergic receptor from rat submaxillary gland |
J Med Chem 38: 3415-44 (1995)
Article DOI: 10.1021/jm00018a001 BindingDB Entry DOI: 10.7270/Q20G3J6W |
More data for this Ligand-Target Pair | |
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50226239
 (CHEMBL50451)Show SMILES COc1nc(OC)nc(n1)N1CCN(CC1)c1nc(N)c2cc(OC)c(OC)cc2n1 Show InChI InChI=1S/C19H24N8O4/c1-28-13-9-11-12(10-14(13)29-2)21-16(22-15(11)20)26-5-7-27(8-6-26)17-23-18(30-3)25-19(24-17)31-4/h9-10H,5-8H2,1-4H3,(H2,20,21,22) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.0800 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description Binding affinity against alpha-1-adrenoceptor in rat brain homogenates [3H]-prazosin displacement. |
J Med Chem 30: 1794-8 (1987)
Article DOI: 10.1021/jm00393a019 BindingDB Entry DOI: 10.7270/Q2W0985N |
More data for this Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50100229
 (3-[2-(6-Methoxy-1,3,3a,4,5,9b-hexahydro-benzo[e]is...)Show SMILES COc1cccc2[C@@H]3CN(CCn4c(=O)[nH]c5cc(ccc5c4=O)C#N)C[C@@H]3CCc12 Show InChI InChI=1S/C24H24N4O3/c1-31-22-4-2-3-17-18(22)8-6-16-13-27(14-20(16)17)9-10-28-23(29)19-7-5-15(12-25)11-21(19)26-24(28)30/h2-5,7,11,16,20H,6,8-10,13-14H2,1H3,(H,26,30)/t16-,20+/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.0900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity to alpha-1A adrenergic receptor in rat submaxillary gland |
J Med Chem 44: 1971-85 (2001)
Article DOI: 10.1021/jm000541z BindingDB Entry DOI: 10.7270/Q2KP81GH |
More data for this Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50100214
 (3-[2-(6-Methoxy-1,3,3a,4,5,9b-hexahydro-benzo[e]is...)Show SMILES COc1cccc2[C@@H]3CN(CCn4c(=O)[nH]c5c(C)c(C)ccc5c4=O)C[C@@H]3CCc12 Show InChI InChI=1S/C25H29N3O3/c1-15-7-9-20-23(16(15)2)26-25(30)28(24(20)29)12-11-27-13-17-8-10-19-18(21(17)14-27)5-4-6-22(19)31-3/h4-7,9,17,21H,8,10-14H2,1-3H3,(H,26,30)/t17-,21+/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.0900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity to alpha-1A adrenergic receptor in rat submaxillary gland |
J Med Chem 44: 1971-85 (2001)
Article DOI: 10.1021/jm000541z BindingDB Entry DOI: 10.7270/Q2KP81GH |
More data for this Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50100238
 (7-Methoxy-3-[2-(6-methoxy-1,3,3a,4,5,9b-hexahydro-...)Show SMILES COc1ccc2c(c1)[nH]c(=O)n(CCN1C[C@@H]3CCc4c(OC)cccc4[C@@H]3C1)c2=O Show InChI InChI=1S/C24H27N3O4/c1-30-16-7-9-19-21(12-16)25-24(29)27(23(19)28)11-10-26-13-15-6-8-18-17(20(15)14-26)4-3-5-22(18)31-2/h3-5,7,9,12,15,20H,6,8,10-11,13-14H2,1-2H3,(H,25,29)/t15-,20+/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.0900 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity to alpha-1A adrenergic receptor in rat submaxillary gland |
J Med Chem 44: 1971-85 (2001)
Article DOI: 10.1021/jm000541z BindingDB Entry DOI: 10.7270/Q2KP81GH |
More data for this Ligand-Target Pair | |
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50226814
 (CHEMBL6424)Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCC(CC1)C(=O)NCCc1ccccc1 Show InChI InChI=1S/C24H29N5O3/c1-31-20-14-18-19(15-21(20)32-2)27-24(28-22(18)25)29-12-9-17(10-13-29)23(30)26-11-8-16-6-4-3-5-7-16/h3-7,14-15,17H,8-13H2,1-2H3,(H,26,30)(H2,25,27,28) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro binding affinity determined for alpha-1 adrenergic receptor by the displacement of [3H]- prazosin. |
J Med Chem 30: 999-1003 (1987)
Article DOI: 10.1021/jm00389a007 BindingDB Entry DOI: 10.7270/Q2PC34MG |
More data for this Ligand-Target Pair | |
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50230848
 (CHEMBL70872)Show SMILES COC1=Nc2ccccc2C2=NC(CN3CCN(CC3)c3ccccc3Cl)CN12 Show InChI InChI=1S/C22H24ClN5O/c1-29-22-25-19-8-4-2-6-17(19)21-24-16(15-28(21)22)14-26-10-12-27(13-11-26)20-9-5-3-7-18(20)23/h2-9,16H,10-15H2,1H3 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 0.110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Defense Medical Center
Curated by ChEMBL
| Assay Description Binding affinity against alpha-1 adrenergic receptor by measuring displacement of [3H]prazosin from rat brain cortex membranes (in vitro). |
J Med Chem 36: 2196-207 (1993)
Article DOI: 10.1021/jm00067a017 BindingDB Entry DOI: 10.7270/Q298896M |
More data for this Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM29568
 (CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccco1 Show InChI InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22) | Reactome pathway KEGG
UniProtKB/SwissProt
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CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem
Patents
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| Article PubMed
| 0.120 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institut de Recherches Servier
Curated by PDSP Ki Database
| |
Synapse 35: 79-95 (2000)
Article DOI: 10.1002/(SICI)1098-2396(200002)35:2 BindingDB Entry DOI: 10.7270/Q2XK8D4N |
More data for this Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50060964
 ((R)-5-(2-((2-(2-ethoxyphenoxy)ethyl)amino)propyl)-...)Show SMILES CCOc1ccccc1OCCN[C@H](C)Cc1ccc(OC)c(c1)S(N)(=O)=O Show InChI InChI=1S/C20H28N2O5S/c1-4-26-17-7-5-6-8-18(17)27-12-11-22-15(2)13-16-9-10-19(25-3)20(14-16)28(21,23)24/h5-10,14-15,22H,4,11-13H2,1-3H3,(H2,21,23,24)/t15-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
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CHEBI CHEMBL DrugBank KEGG PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 0.130 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade Federal do Rio de Janeiro
Curated by ChEMBL
| Assay Description Displacement of [3H]prazosin from rat salivary gland adrenergic alpha 1A receptor after 45 mins by liquid scintillation counter |
Eur J Med Chem 46: 3000-12 (2011)
Article DOI: 10.1016/j.ejmech.2011.04.032 BindingDB Entry DOI: 10.7270/Q2M32WVZ |
More data for this Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50393116
 (CHEMBL2153423)Show InChI InChI=1S/C20H24N2O3/c1-23-18-5-3-2-4-17(18)22-12-10-21(11-13-22)9-8-16-6-7-19-20(14-16)25-15-24-19/h2-7,14H,8-13,15H2,1H3 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universidade Federal do Rio de Janeiro
Curated by ChEMBL
| Assay Description Displacement of [3H]prazosin from rat salivary gland adrenergic alpha 1A receptor after 45 mins by liquid scintillation counter |
Eur J Med Chem 46: 3000-12 (2011)
Article DOI: 10.1016/j.ejmech.2011.04.032 BindingDB Entry DOI: 10.7270/Q2M32WVZ |
More data for this Ligand-Target Pair | |
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50227376
 (CHEMBL8689)Show SMILES COc1cc2nc(cc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccco1 Show InChI InChI=1S/C20H22N4O4/c1-26-17-10-13-14(21)11-19(22-15(13)12-18(17)27-2)23-5-7-24(8-6-23)20(25)16-4-3-9-28-16/h3-4,9-12H,5-8H2,1-2H3,(H2,21,22) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.140 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description Binding affinity towards alpha-1 adrenergic receptor from rat brain homogenate preparation by displacement of [3H]prazosin |
J Med Chem 31: 1031-5 (1988)
Article DOI: 10.1021/jm00400a025 BindingDB Entry DOI: 10.7270/Q29W0HPJ |
More data for this Ligand-Target Pair | |
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50227290
 (CHEMBL148457)Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCC(CC1)OCC(O)c1ccccc1 Show InChI InChI=1S/C23H28N4O4/c1-29-20-12-17-18(13-21(20)30-2)25-23(26-22(17)24)27-10-8-16(9-11-27)31-14-19(28)15-6-4-3-5-7-15/h3-7,12-13,16,19,28H,8-11,14H2,1-2H3,(H2,24,25,26) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description Binding affinity for alpha-1 adrenergic receptor by displacement of [3H]-prazosin from rat brain homogenate preparation |
J Med Chem 31: 516-20 (1988)
Article DOI: 10.1021/jm00398a006 BindingDB Entry DOI: 10.7270/Q2ZP48BH |
More data for this Ligand-Target Pair | |
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50227298
 (CHEMBL147255)Show SMILES CCOC(C)(COC1CCN(CC1)c1nc(N)c2cc(OC)c(OC)cc2n1)c1ccccc1 Show InChI InChI=1S/C26H34N4O4/c1-5-34-26(2,18-9-7-6-8-10-18)17-33-19-11-13-30(14-12-19)25-28-21-16-23(32-4)22(31-3)15-20(21)24(27)29-25/h6-10,15-16,19H,5,11-14,17H2,1-4H3,(H2,27,28,29) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description Binding affinity for alpha-1 adrenergic receptor by displacement of [3H]-prazosin from rat brain homogenate preparation |
J Med Chem 31: 516-20 (1988)
Article DOI: 10.1021/jm00398a006 BindingDB Entry DOI: 10.7270/Q2ZP48BH |
More data for this Ligand-Target Pair | |
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM29568
 (CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccco1 Show InChI InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar
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Patents
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| Article PubMed
| 0.150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description Binding affinity for alpha-1 adrenergic receptor by displacement of [3H]-prazosin from rat brain homogenate preparation |
J Med Chem 31: 516-20 (1988)
Article DOI: 10.1021/jm00398a006 BindingDB Entry DOI: 10.7270/Q2ZP48BH |
More data for this Ligand-Target Pair | |
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50226234
 (CHEMBL50979)Show SMILES COc1cc(nc(OC)n1)N1CCN(CC1)c1nc(N)c2cc(OC)c(OC)cc2n1 Show InChI InChI=1S/C20H25N7O4/c1-28-14-9-12-13(10-15(14)29-2)22-19(25-18(12)21)27-7-5-26(6-8-27)16-11-17(30-3)24-20(23-16)31-4/h9-11H,5-8H2,1-4H3,(H2,21,22,25) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar
| CHEMBL MMDB PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 0.160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description Binding affinity against alpha-1-adrenoceptor in rat brain homogenates [3H]-prazosin displacement. |
J Med Chem 30: 1794-8 (1987)
Article DOI: 10.1021/jm00393a019 BindingDB Entry DOI: 10.7270/Q2W0985N |
More data for this Ligand-Target Pair | |
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM29568
 (CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccco1 Show InChI InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22) | Reactome pathway KEGG
UniProtKB/SwissProt
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Patents
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| Article PubMed
| 0.160 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Compound was tested for the inhibition of [3H]prazosin binding Alpha-1 adrenergic receptor of crude rat brain membrane. |
J Med Chem 25: 75-81 (1982)
Article DOI: 10.1021/jm00343a015 BindingDB Entry DOI: 10.7270/Q2TM7DBC |
More data for this Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50133938
 (Aceperone | CHEMBL136298 | N-{1-[4-(4-Fluoro-pheny...)Show SMILES CC(=O)NCC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccccc1 Show InChI InChI=1S/C24H29FN2O2/c1-19(28)26-18-24(21-6-3-2-4-7-21)13-16-27(17-14-24)15-5-8-23(29)20-9-11-22(25)12-10-20/h2-4,6-7,9-12H,5,8,13-18H2,1H3,(H,26,28) | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research Foundation
Curated by PDSP Ki Database
| |
Psychopharmacology (Berl) 124: 57-73 (1996)
Article DOI: 10.1007/bf02245606 BindingDB Entry DOI: 10.7270/Q2610XV6 |
More data for this Ligand-Target Pair | |
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50226235
 (CHEMBL54288)Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)c1cc(OC(C)C)ncn1 Show InChI InChI=1S/C21H27N7O3/c1-13(2)31-19-11-18(23-12-24-19)27-5-7-28(8-6-27)21-25-15-10-17(30-4)16(29-3)9-14(15)20(22)26-21/h9-13H,5-8H2,1-4H3,(H2,22,25,26) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description Binding affinity against alpha-1-adrenoceptor in rat brain homogenates [3H]-prazosin displacement. |
J Med Chem 30: 1794-8 (1987)
Article DOI: 10.1021/jm00393a019 BindingDB Entry DOI: 10.7270/Q2W0985N |
More data for this Ligand-Target Pair | |
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50226227
 (CHEMBL52155)Show InChI InChI=1S/C18H21N7O2/c1-26-14-9-12-13(10-15(14)27-2)22-18(23-17(12)19)25-7-5-24(6-8-25)16-11-20-3-4-21-16/h3-4,9-11H,5-8H2,1-2H3,(H2,19,22,23) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description Binding affinity against alpha-1-adrenoceptor in rat brain homogenates [3H]-prazosin displacement. |
J Med Chem 30: 1794-8 (1987)
Article DOI: 10.1021/jm00393a019 BindingDB Entry DOI: 10.7270/Q2W0985N |
More data for this Ligand-Target Pair | |
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM29568
 (CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccco1 Show InChI InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar
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CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem
Patents
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| Article PubMed
| 0.190 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description Binding affinity to Alpha-1 adrenergic receptor by displacement of [3H]prazosin |
J Med Chem 31: 1036-9 (1988)
Article DOI: 10.1021/jm00400a026 BindingDB Entry DOI: 10.7270/Q2639RZK |
More data for this Ligand-Target Pair | |
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM29568
 (CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccco1 Show InChI InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar
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CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem
Patents
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| Article PubMed
| 0.190 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Defense Medical Center
Curated by ChEMBL
| Assay Description Binding affinity against alpha-1 adrenergic receptor by measuring displacement of [3H]prazosin from rat brain cortex membranes (in vitro). |
J Med Chem 36: 2196-207 (1993)
Article DOI: 10.1021/jm00067a017 BindingDB Entry DOI: 10.7270/Q298896M |
More data for this Ligand-Target Pair | |
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM29568
 (CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccco1 Show InChI InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar
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CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| 0.190 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro binding affinity determined for alpha-1 adrenergic receptor by the displacement of [3H]- prazosin. |
J Med Chem 30: 999-1003 (1987)
Article DOI: 10.1021/jm00389a007 BindingDB Entry DOI: 10.7270/Q2PC34MG |
More data for this Ligand-Target Pair | |
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM29568
 (CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccco1 Show InChI InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar
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CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| 0.190 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description Binding affinity towards alpha-1 adrenergic receptor from rat brain homogenate preparation by displacement of [3H]prazosin |
J Med Chem 31: 1031-5 (1988)
Article DOI: 10.1021/jm00400a025 BindingDB Entry DOI: 10.7270/Q29W0HPJ |
More data for this Ligand-Target Pair | |
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM29568
 (CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccco1 Show InChI InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar
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CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| 0.190 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Compound was tested for its binding affinity for alpha-1 adrenergic receptor site by displacement of [3H]clonidine at 10e-6 M concentration |
J Med Chem 30: 49-57 (1987)
Article DOI: 10.1021/jm00384a009 BindingDB Entry DOI: 10.7270/Q24J0HCH |
More data for this Ligand-Target Pair | |
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50226233
 (CHEMBL275524)Show SMILES COc1ccnc(n1)N1CCN(CC1)c1nc(N)c2cc(OC)c(OC)cc2n1 Show InChI InChI=1S/C19H23N7O3/c1-27-14-10-12-13(11-15(14)28-2)22-19(24-17(12)20)26-8-6-25(7-9-26)18-21-5-4-16(23-18)29-3/h4-5,10-11H,6-9H2,1-3H3,(H2,20,22,24) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.190 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description Binding affinity against alpha-1-adrenoceptor in rat brain homogenates [3H]-prazosin displacement. |
J Med Chem 30: 1794-8 (1987)
Article DOI: 10.1021/jm00393a019 BindingDB Entry DOI: 10.7270/Q2W0985N |
More data for this Ligand-Target Pair | |
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM29568
 (CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccco1 Show InChI InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar
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CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| 0.190 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description Binding affinity against alpha-1-adrenoceptor was determined by displacement of [3H]-prazosin in rat brain homogenates. |
J Med Chem 30: 1794-8 (1987)
Article DOI: 10.1021/jm00393a019 BindingDB Entry DOI: 10.7270/Q2W0985N |
More data for this Ligand-Target Pair | |
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50109058
 (1H-4-indolyl 2-[4-(1H-3-indolyl)-1,2,3,6-tetrahydr...)Show SMILES C(CN1CCC(=CC1)c1c[nH]c2ccccc12)Oc1cccc2[nH]ccc12 Show InChI InChI=1S/C23H23N3O/c1-2-5-21-18(4-1)20(16-25-21)17-9-12-26(13-10-17)14-15-27-23-7-3-6-22-19(23)8-11-24-22/h1-9,11,16,24-25H,10,12-15H2 | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.190 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth-Ayerst Research Laboratories
Curated by ChEMBL
| Assay Description In vitro binding affinity towards Alpha-1 adrenergic receptor was determined by the displacement of [3H]prazosin |
Bioorg Med Chem Lett 12: 307-10 (2002)
Article DOI: 10.1016/s0960-894x(01)00746-6 BindingDB Entry DOI: 10.7270/Q2FJ2G2M |
More data for this Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50029257
 ((3-((4-(2-isopropoxyphenyl)piperazin-1-yl)methyl)p...)Show SMILES CC(C)Oc1ccccc1N1CCN(Cc2cccc(c2)C(=O)N2CCCCC2)CC1 Show InChI InChI=1S/C26H35N3O2/c1-21(2)31-25-12-5-4-11-24(25)28-17-15-27(16-18-28)20-22-9-8-10-23(19-22)26(30)29-13-6-3-7-14-29/h4-5,8-12,19,21H,3,6-7,13-18,20H2,1-2H3 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
R. W. Johnson Pharmaceutical Research Institute
Curated by ChEMBL
| Assay Description Binding affinity towards alpha-1A adrenergic receptors using alpha1A ligand WB4101 |
J Med Chem 37: 1060-2 (1994)
Article DOI: 10.1021/jm00034a003 BindingDB Entry DOI: 10.7270/Q23R0RXB |
More data for this Ligand-Target Pair | |
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50226844
 (CHEMBL415288)Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCC(CC1)C(=O)N(C)Cc1ccccc1 Show InChI InChI=1S/C24H29N5O3/c1-28(15-16-7-5-4-6-8-16)23(30)17-9-11-29(12-10-17)24-26-19-14-21(32-3)20(31-2)13-18(19)22(25)27-24/h4-8,13-14,17H,9-12,15H2,1-3H3,(H2,25,26,27) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 0.200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro binding affinity determined for alpha-1 adrenergic receptor by the displacement of [3H]- prazosin. |
J Med Chem 30: 999-1003 (1987)
Article DOI: 10.1021/jm00389a007 BindingDB Entry DOI: 10.7270/Q2PC34MG |
More data for this Ligand-Target Pair | |
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50066109
 (3-[4-(2-Methoxy-phenyl)-piperazin-1-ylmethyl]-2,6-...)Show SMILES COc1ccccc1N1CCN(CC2CN=C3N2C(=O)Nc2ccccc32)CC1 Show InChI InChI=1S/C22H25N5O2/c1-29-20-9-5-4-8-19(20)26-12-10-25(11-13-26)15-16-14-23-21-17-6-2-3-7-18(17)24-22(28)27(16)21/h2-9,16H,10-15H2,1H3,(H,24,28) | Reactome pathway KEGG
UniProtKB/SwissProt
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| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.210 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Defense Medical Center
Curated by ChEMBL
| Assay Description Binding affinity against alpha-1 adrenergic receptor by measuring displacement of [3H]prazosin from rat brain cortex membranes (in vitro). |
J Med Chem 36: 2196-207 (1993)
Article DOI: 10.1021/jm00067a017 BindingDB Entry DOI: 10.7270/Q298896M |
More data for this Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50006952
 (2-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...)Show SMILES COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c4ccccc4[nH]c3c2=O)CC1 Show InChI InChI=1S/C23H25N5O3/c1-31-19-9-5-4-8-18(19)27-13-10-26(11-14-27)12-15-28-22(29)21-20(25-23(28)30)16-6-2-3-7-17(16)24-21/h2-9,24H,10-15H2,1H3,(H,25,30) | Reactome pathway KEGG
UniProtKB/SwissProt
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| 0.210 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universitá di Catania
Curated by ChEMBL
| Assay Description Binding affinity for Alpha-1 adrenergic receptor measured by displacing [3H]-prazosin from rat cortical membranes |
J Med Chem 34: 1850-4 (1991)
Article DOI: 10.1021/jm00110a014 BindingDB Entry DOI: 10.7270/Q25B01FV |
More data for this Ligand-Target Pair | |
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50006952
 (2-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-...)Show SMILES COc1ccccc1N1CCN(CCn2c(=O)[nH]c3c4ccccc4[nH]c3c2=O)CC1 Show InChI InChI=1S/C23H25N5O3/c1-31-19-9-5-4-8-18(19)27-13-10-26(11-14-27)12-15-28-22(29)21-20(25-23(28)30)16-6-2-3-7-17(16)24-21/h2-9,24H,10-15H2,1H3,(H,25,30) | Reactome pathway KEGG
UniProtKB/SwissProt
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| 0.210 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Perugia
Curated by ChEMBL
| Assay Description Alpha-1-adrenergic receptor binding affinity of the compound, value taken from literature |
J Med Chem 44: 2118-32 (2001)
BindingDB Entry DOI: 10.7270/Q2W3802N |
More data for this Ligand-Target Pair | |
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50226846
 (CHEMBL6474)Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCC(CC1)C(=O)NCc1ccccc1 Show InChI InChI=1S/C23H27N5O3/c1-30-19-12-17-18(13-20(19)31-2)26-23(27-21(17)24)28-10-8-16(9-11-28)22(29)25-14-15-6-4-3-5-7-15/h3-7,12-13,16H,8-11,14H2,1-2H3,(H,25,29)(H2,24,26,27) | Reactome pathway KEGG
UniProtKB/SwissProt
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| CHEMBL PC cid PC sid UniChem
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| Article PubMed
| 0.220 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro binding affinity determined for alpha-1 adrenergic receptor by the displacement of [3H]- prazosin. |
J Med Chem 30: 999-1003 (1987)
Article DOI: 10.1021/jm00389a007 BindingDB Entry DOI: 10.7270/Q2PC34MG |
More data for this Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM29568
 (CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccco1 Show InChI InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22) | Reactome pathway KEGG
UniProtKB/SwissProt
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| Article PubMed
| 0.230 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Toray Industries Inc
Curated by ChEMBL
| Assay Description Displacement of [3H]prazosin from adrenergic alpha-1A receptor in rat submaxillary gland membranes |
Bioorg Med Chem Lett 16: 4045-7 (2006)
Article DOI: 10.1016/j.bmcl.2006.05.002 BindingDB Entry DOI: 10.7270/Q2514001 |
More data for this Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50369383
 (CHEMBL1788222)Show SMILES COc1ccccc1N1CCN(C[C@H]2CN=C3N2C(=O)Nc2ccccc32)CC1 Show InChI InChI=1S/C22H25N5O2/c1-29-20-9-5-4-8-19(20)26-12-10-25(11-13-26)15-16-14-23-21-17-6-2-3-7-18(17)24-22(28)27(16)21/h2-9,16H,10-15H2,1H3,(H,24,28)/t16-/m1/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.230 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Taiwan University
Curated by ChEMBL
| Assay Description Displacement of [3H]prazosin from Alpha-1A adrenergic receptorof rat submaxillary gland membranes |
J Med Chem 41: 3128-41 (1998)
Article DOI: 10.1021/jm970159v BindingDB Entry DOI: 10.7270/Q2GM880H |
More data for this Ligand-Target Pair | |
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM29568
 (CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccco1 Show InChI InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22) | Reactome pathway KEGG
UniProtKB/SwissProt
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| 0.240 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Pisa
Curated by ChEMBL
| Assay Description Binding affinity by its ability to displace [3H]prazosin radioligand from Alpha-1 adrenergic receptor on rat cerebral cortex |
Bioorg Med Chem Lett 12: 437-40 (2002)
Article DOI: 10.1016/s0960-894x(01)00772-7 BindingDB Entry DOI: 10.7270/Q2XW4N1S |
More data for this Ligand-Target Pair | |
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM29568
 (CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccco1 Show InChI InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22) | Reactome pathway KEGG
UniProtKB/SwissProt
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CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem
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| 0.240 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Perugia
Curated by ChEMBL
| Assay Description Binding affinity towards alpha-1 adrenergic receptor in rat cortex membrane using [3H]-prazosin radioligand |
J Med Chem 44: 2118-32 (2001)
BindingDB Entry DOI: 10.7270/Q2W3802N |
More data for this Ligand-Target Pair | |
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50226237
 (CHEMBL299584)Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)c1ccnc(Oc2ccccc2)n1 Show InChI InChI=1S/C24H25N7O3/c1-32-19-14-17-18(15-20(19)33-2)27-23(29-22(17)25)31-12-10-30(11-13-31)21-8-9-26-24(28-21)34-16-6-4-3-5-7-16/h3-9,14-15H,10-13H2,1-2H3,(H2,25,27,29) | Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 0.240 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc
Curated by ChEMBL
| Assay Description Binding affinity against alpha-1-adrenoceptor in rat brain homogenates [3H]-prazosin displacement. |
J Med Chem 30: 1794-8 (1987)
Article DOI: 10.1021/jm00393a019 BindingDB Entry DOI: 10.7270/Q2W0985N |
More data for this Ligand-Target Pair | |
Alpha-1A adrenergic receptor
(Rattus norvegicus (Rat)) | BDBM50100233
 (6,7-Dimethoxy-3-[2-(6-methoxy-1,3,3a,4,5,9b-hexahy...)Show SMILES COc1cc2[nH]c(=O)n(CCN3C[C@@H]4CCc5c(OC)cccc5[C@@H]4C3)c(=O)c2cc1OC Show InChI InChI=1S/C25H29N3O5/c1-31-21-6-4-5-16-17(21)8-7-15-13-27(14-19(15)16)9-10-28-24(29)18-11-22(32-2)23(33-3)12-20(18)26-25(28)30/h4-6,11-12,15,19H,7-10,13-14H2,1-3H3,(H,26,30)/t15-,19+/m0/s1 | Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar
| CHEMBL PC cid PC sid UniChem
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| Article PubMed
| 0.240 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description Binding affinity to alpha-1A adrenergic receptor in rat submaxillary gland |
J Med Chem 44: 1971-85 (2001)
Article DOI: 10.1021/jm000541z BindingDB Entry DOI: 10.7270/Q2KP81GH |
More data for this Ligand-Target Pair | |
Alpha-1 Adrenergic Receptor/ adrenergic receptor/ adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM29568
 (CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccco1 Show InChI InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22) | Reactome pathway KEGG
UniProtKB/SwissProt
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CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem
Patents
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| Article PubMed
| 0.240 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Università di Pisa
Curated by ChEMBL
| Assay Description Binding affinity towards Alpha-1 adrenergic receptor in rat cerebral cortex using [3H]prazosin |
Bioorg Med Chem Lett 13: 171-3 (2002)
Article DOI: 10.1016/s0960-894x(02)00932-0 BindingDB Entry DOI: 10.7270/Q2TM79GX |
More data for this Ligand-Target Pair | |