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Compile Data Set for Download or QSAR

Found 323 hits of ic50 for UniProtKB: P02766   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transthyretin


(Homo sapiens (Human))
BDBM249550
PNG
(US10072016, Compound 148 | US10407433, Compound 14...)
Show SMILES Fc1cccc(C2CCN(CC2)C(=O)c2n[nH]c3CN(CCc23)C#N)c1Cl
Show InChI InChI=1S/C19H19ClFN5O/c20-17-13(2-1-3-15(17)21)12-4-8-26(9-5-12)19(27)18-14-6-7-25(11-22)10-16(14)23-24-18/h1-3,12H,4-10H2,(H,23,24)
PDB

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UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a<0.169n/an/an/an/a7.425



Columbia University

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US10072016 (2018)


Article DOI: 10.1021/jm050333c
BindingDB Entry DOI: 10.7270/Q2QJ7KBT
More data for this
Ligand-Target Pair
Transthyretin


(Homo sapiens (Human))
BDBM249474
PNG
(US10072016, Compound 77 | US10407433, Compound 77 ...)
Show SMILES COCCN1CCc2c(C1)[nH]nc2C(=O)N1CCC(CC1)c1cccc(F)c1C(F)(F)F
Show InChI InChI=1S/C22H26F4N4O2/c1-32-12-11-29-8-7-16-18(13-29)27-28-20(16)21(31)30-9-5-14(6-10-30)15-3-2-4-17(23)19(15)22(24,25)26/h2-4,14H,5-13H2,1H3,(H,27,28)
PDB

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UniProtKB/SwissProt
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DrugBank
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 1.62n/an/an/an/a7.425



Columbia University

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US10072016 (2018)


Article DOI: 10.1021/jm050333c
BindingDB Entry DOI: 10.7270/Q2QJ7KBT
More data for this
Ligand-Target Pair
Transthyretin


(Homo sapiens (Human))
BDBM249485
PNG
(US10072016, Compound 83 | US10407433, Compound 83 ...)
Show SMILES CC(=O)N1Cc2[nH]nc(C(=O)N3CCC(CC3)c3ccc(F)c(F)c3C(F)(F)F)c2C1
Show InChI InChI=1S/C20H19F5N4O2/c1-10(30)29-8-13-15(9-29)26-27-18(13)19(31)28-6-4-11(5-7-28)12-2-3-14(21)17(22)16(12)20(23,24)25/h2-3,11H,4-9H2,1H3,(H,26,27)
PDB

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UniProtKB/SwissProt
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GoogleScholar
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PC sid
UniChem
Article
US Patent
n/an/a 4.85n/an/an/an/a7.425



Columbia University

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US10072016 (2018)


Article DOI: 10.1021/jm050333c
BindingDB Entry DOI: 10.7270/Q2QJ7KBT
More data for this
Ligand-Target Pair
Transthyretin


(Homo sapiens (Human))
BDBM249481
PNG
(US10072016, Compound 79 | US10407433, Compound 79 ...)
Show SMILES Fc1cccc(C2CCN(CC2)C(=O)c2n[nH]c3CN(CC4CC4)CCc23)c1C(F)(F)F
Show InChI InChI=1S/C23H26F4N4O/c24-18-3-1-2-16(20(18)23(25,26)27)15-6-10-31(11-7-15)22(32)21-17-8-9-30(12-14-4-5-14)13-19(17)28-29-21/h1-3,14-15H,4-13H2,(H,28,29)
PDB

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UniChem
Article
US Patent
n/an/a 6.10n/an/an/an/a7.425



Columbia University

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US10072016 (2018)


Article DOI: 10.1021/jm050333c
BindingDB Entry DOI: 10.7270/Q2QJ7KBT
More data for this
Ligand-Target Pair
Transthyretin


(Homo sapiens (Human))
BDBM249550
PNG
(US10072016, Compound 148 | US10407433, Compound 14...)
Show SMILES Fc1cccc(C2CCN(CC2)C(=O)c2n[nH]c3CN(CCc23)C#N)c1Cl
Show InChI InChI=1S/C19H19ClFN5O/c20-17-13(2-1-3-15(17)21)12-4-8-26(9-5-12)19(27)18-14-6-7-25(11-22)10-16(14)23-24-18/h1-3,12H,4-10H2,(H,23,24)
PDB

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UniProtKB/SwissProt
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GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 7.41n/an/an/an/a7.425



Columbia University

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US10072016 (2018)


Article DOI: 10.1021/jm050333c
BindingDB Entry DOI: 10.7270/Q2QJ7KBT
More data for this
Ligand-Target Pair
Transthyretin


(Homo sapiens (Human))
BDBM249534
PNG
(US10072016, Compound 132 | US10407433, Compound 13...)
Show SMILES Fc1cc(F)c(c(c1)C1CCN(CC1)C(=O)c1nnc2ccc(cn12)C#N)C(F)(F)F
Show InChI InChI=1S/C20H14F5N5O/c21-13-7-14(17(15(22)8-13)20(23,24)25)12-3-5-29(6-4-12)19(31)18-28-27-16-2-1-11(9-26)10-30(16)18/h1-2,7-8,10,12H,3-6H2
PDB

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UniProtKB/SwissProt
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GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 10.5n/an/an/an/a7.425



Columbia University

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US10072016 (2018)


Article DOI: 10.1021/jm050333c
BindingDB Entry DOI: 10.7270/Q2QJ7KBT
More data for this
Ligand-Target Pair
Transthyretin


(Homo sapiens (Human))
BDBM249474
PNG
(US10072016, Compound 77 | US10407433, Compound 77 ...)
Show SMILES COCCN1CCc2c(C1)[nH]nc2C(=O)N1CCC(CC1)c1cccc(F)c1C(F)(F)F
Show InChI InChI=1S/C22H26F4N4O2/c1-32-12-11-29-8-7-16-18(13-29)27-28-20(16)21(31)30-9-5-14(6-10-30)15-3-2-4-17(23)19(15)22(24,25)26/h2-4,14H,5-13H2,1H3,(H,27,28)
PDB

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UniProtKB/SwissProt
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GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 10.6n/an/an/an/a7.425



Columbia University

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US10072016 (2018)


Article DOI: 10.1021/jm050333c
BindingDB Entry DOI: 10.7270/Q2QJ7KBT
More data for this
Ligand-Target Pair
Transthyretin


(Homo sapiens (Human))
BDBM249564
PNG
(US10072016, Compound 162 | US10407433, Compound 16...)
Show SMILES FC(F)(F)c1c(Cl)cccc1C1CCN(CC1)C(=O)c1nnc2ccc(cn12)C#N
Show InChI InChI=1S/C20H15ClF3N5O/c21-15-3-1-2-14(17(15)20(22,23)24)13-6-8-28(9-7-13)19(30)18-27-26-16-5-4-12(10-25)11-29(16)18/h1-5,11,13H,6-9H2
PDB

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UniProtKB/SwissProt
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GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 10.7n/an/an/an/a7.425



Columbia University

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US10072016 (2018)


Article DOI: 10.1021/jm050333c
BindingDB Entry DOI: 10.7270/Q2QJ7KBT
More data for this
Ligand-Target Pair
Transthyretin


(Homo sapiens (Human))
BDBM249533
PNG
(US10072016, Compound 131 | US10407433, Compound 13...)
Show SMILES CC(=O)N1CCc2c(C1)[nH]nc2C(=O)N1CCC(CC1)c1cc(F)cc(F)c1C(F)(F)F
Show InChI InChI=1S/C21H21F5N4O2/c1-11(31)30-7-4-14-17(10-30)27-28-19(14)20(32)29-5-2-12(3-6-29)15-8-13(22)9-16(23)18(15)21(24,25)26/h8-9,12H,2-7,10H2,1H3,(H,27,28)
PDB

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UniProtKB/SwissProt
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B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 10.9n/an/an/an/a7.425



Columbia University

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US10072016 (2018)


Article DOI: 10.1021/jm050333c
BindingDB Entry DOI: 10.7270/Q2QJ7KBT
More data for this
Ligand-Target Pair
Transthyretin


(Homo sapiens (Human))
BDBM249538
PNG
(US10072016, Compound 136 | US10407433, Compound 13...)
Show SMILES Fc1cc(F)c(c(c1)C1CCN(CC1)C(=O)c1n[nH]c2CN(CCc12)C#N)C(F)(F)F
Show InChI InChI=1S/C20H18F5N5O/c21-12-7-14(17(15(22)8-12)20(23,24)25)11-1-5-30(6-2-11)19(31)18-13-3-4-29(10-26)9-16(13)27-28-18/h7-8,11H,1-6,9H2,(H,27,28)
PDB

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UniProtKB/SwissProt
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DrugBank
GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 12n/an/an/an/a7.425



Columbia University

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US10072016 (2018)


Article DOI: 10.1021/jm050333c
BindingDB Entry DOI: 10.7270/Q2QJ7KBT
More data for this
Ligand-Target Pair
Transthyretin


(Homo sapiens (Human))
BDBM249466
PNG
(US10072016, Compound 65 | US10407433, Compound 65 ...)
Show SMILES Fc1cccc(C2CCN(CC2)C(=O)c2nnc3ccc(cn23)C#N)c1C(F)(F)F
Show InChI InChI=1S/C20H15F4N5O/c21-15-3-1-2-14(17(15)20(22,23)24)13-6-8-28(9-7-13)19(30)18-27-26-16-5-4-12(10-25)11-29(16)18/h1-5,11,13H,6-9H2
PDB

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GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 12.7n/an/an/an/a7.425



Columbia University

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US10072016 (2018)


Article DOI: 10.1021/jm050333c
BindingDB Entry DOI: 10.7270/Q2QJ7KBT
More data for this
Ligand-Target Pair
Transthyretin


(Homo sapiens (Human))
BDBM249466
PNG
(US10072016, Compound 65 | US10407433, Compound 65 ...)
Show SMILES Fc1cccc(C2CCN(CC2)C(=O)c2nnc3ccc(cn23)C#N)c1C(F)(F)F
Show InChI InChI=1S/C20H15F4N5O/c21-15-3-1-2-14(17(15)20(22,23)24)13-6-8-28(9-7-13)19(30)18-27-26-16-5-4-12(10-25)11-29(16)18/h1-5,11,13H,6-9H2
PDB

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GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 12.7n/an/an/an/a7.425



Columbia University

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US10072016 (2018)


Article DOI: 10.1021/jm050333c
BindingDB Entry DOI: 10.7270/Q2QJ7KBT
More data for this
Ligand-Target Pair
Transthyretin


(Homo sapiens (Human))
BDBM249466
PNG
(US10072016, Compound 65 | US10407433, Compound 65 ...)
Show SMILES Fc1cccc(C2CCN(CC2)C(=O)c2nnc3ccc(cn23)C#N)c1C(F)(F)F
Show InChI InChI=1S/C20H15F4N5O/c21-15-3-1-2-14(17(15)20(22,23)24)13-6-8-28(9-7-13)19(30)18-27-26-16-5-4-12(10-25)11-29(16)18/h1-5,11,13H,6-9H2
PDB

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GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 12.7n/an/an/an/a7.425



Columbia University

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US10072016 (2018)


Article DOI: 10.1021/jm050333c
BindingDB Entry DOI: 10.7270/Q2QJ7KBT
More data for this
Ligand-Target Pair
Transthyretin


(Homo sapiens (Human))
BDBM249466
PNG
(US10072016, Compound 65 | US10407433, Compound 65 ...)
Show SMILES Fc1cccc(C2CCN(CC2)C(=O)c2nnc3ccc(cn23)C#N)c1C(F)(F)F
Show InChI InChI=1S/C20H15F4N5O/c21-15-3-1-2-14(17(15)20(22,23)24)13-6-8-28(9-7-13)19(30)18-27-26-16-5-4-12(10-25)11-29(16)18/h1-5,11,13H,6-9H2
PDB

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GoogleScholar
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UniChem
Article
US Patent
n/an/a 12.8n/an/an/an/a7.425



Columbia University

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US10072016 (2018)


Article DOI: 10.1021/jm050333c
BindingDB Entry DOI: 10.7270/Q2QJ7KBT
More data for this
Ligand-Target Pair
Transthyretin


(Homo sapiens (Human))
BDBM249482
PNG
(US10072016, Compound 81 | US10407433, Compound 81 ...)
Show SMILES CC(=O)N1CCc2c(C1)[nH]nc2C(=O)N1CCC(CC1)c1ccc(F)c(F)c1C(F)(F)F
Show InChI InChI=1S/C21H21F5N4O2/c1-11(31)30-9-6-14-16(10-30)27-28-19(14)20(32)29-7-4-12(5-8-29)13-2-3-15(22)18(23)17(13)21(24,25)26/h2-3,12H,4-10H2,1H3,(H,27,28)
PDB

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UniChem
Article
US Patent
n/an/a 13.9n/an/an/an/a7.425



Columbia University

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US10072016 (2018)


Article DOI: 10.1021/jm050333c
BindingDB Entry DOI: 10.7270/Q2QJ7KBT
More data for this
Ligand-Target Pair
Transthyretin


(Homo sapiens (Human))
BDBM249503
PNG
(US10072016, Compound 101 | US10407433, Compound 10...)
Show SMILES COC(=O)N1Cc2[nH]nc(C(=O)N3CCC(CC3)c3ccc(F)c(F)c3C(F)(F)F)c2C1
Show InChI InChI=1S/C20H19F5N4O3/c1-32-19(31)29-8-12-14(9-29)26-27-17(12)18(30)28-6-4-10(5-7-28)11-2-3-13(21)16(22)15(11)20(23,24)25/h2-3,10H,4-9H2,1H3,(H,26,27)
PDB

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UniChem
Article
US Patent
n/an/a 14.1n/an/an/an/a7.425



Columbia University

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US10072016 (2018)


Article DOI: 10.1021/jm050333c
BindingDB Entry DOI: 10.7270/Q2QJ7KBT
More data for this
Ligand-Target Pair
Transthyretin


(Homo sapiens (Human))
BDBM249520
PNG
(US10072016, Compound 118 | US10407433, Compound 11...)
Show SMILES Fc1ccc(C2CCN(CC2)C(=O)c2n[nH]c3CN(CC4CC4)CCc23)c(c1F)C(F)(F)F
Show InChI InChI=1S/C23H25F5N4O/c24-17-4-3-15(19(20(17)25)23(26,27)28)14-5-9-32(10-6-14)22(33)21-16-7-8-31(11-13-1-2-13)12-18(16)29-30-21/h3-4,13-14H,1-2,5-12H2,(H,29,30)
PDB

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UniChem
Article
US Patent
n/an/a 14.2n/an/an/an/a7.425



Columbia University

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US10072016 (2018)


Article DOI: 10.1021/jm050333c
BindingDB Entry DOI: 10.7270/Q2QJ7KBT
More data for this
Ligand-Target Pair
Transthyretin


(Homo sapiens (Human))
BDBM249486
PNG
(US10072016, Compound 84 | US10407433, Compound 84 ...)
Show SMILES CCC(=O)N1Cc2[nH]nc(C(=O)N3CCC(CC3)c3ccc(F)c(F)c3C(F)(F)F)c2C1
Show InChI InChI=1S/C21H21F5N4O2/c1-2-16(31)30-9-13-15(10-30)27-28-19(13)20(32)29-7-5-11(6-8-29)12-3-4-14(22)18(23)17(12)21(24,25)26/h3-4,11H,2,5-10H2,1H3,(H,27,28)
PDB

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PC sid
UniChem
Article
US Patent
n/an/a 14.7n/an/an/an/a7.425



Columbia University

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US10072016 (2018)


Article DOI: 10.1021/jm050333c
BindingDB Entry DOI: 10.7270/Q2QJ7KBT
More data for this
Ligand-Target Pair
Transthyretin


(Homo sapiens (Human))
BDBM249532
PNG
(US10072016, Compound 130 | US10407433, Compound 13...)
Show SMILES COC(=O)N1CCc2c(C1)[nH]nc2C(=O)N1CCC(CC1)c1cc(F)cc(F)c1C(F)(F)F
Show InChI InChI=1S/C21H21F5N4O3/c1-33-20(32)30-7-4-13-16(10-30)27-28-18(13)19(31)29-5-2-11(3-6-29)14-8-12(22)9-15(23)17(14)21(24,25)26/h8-9,11H,2-7,10H2,1H3,(H,27,28)
PDB

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GoogleScholar
PC cid
PC sid
UniChem
Article
US Patent
n/an/a 14.9n/an/an/an/a7.425



Columbia University

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US10072016 (2018)


Article DOI: 10.1021/jm050333c
BindingDB Entry DOI: 10.7270/Q2QJ7KBT
More data for this
Ligand-Target Pair
Transthyretin


(Homo sapiens (Human))
BDBM249482
PNG
(US10072016, Compound 81 | US10407433, Compound 81 ...)
Show SMILES CC(=O)N1CCc2c(C1)[nH]nc2C(=O)N1CCC(CC1)c1ccc(F)c(F)c1C(F)(F)F
Show InChI InChI=1S/C21H21F5N4O2/c1-11(31)30-9-6-14-16(10-30)27-28-19(14)20(32)29-7-4-12(5-8-29)13-2-3-15(22)18(23)17(13)21(24,25)26/h2-3,12H,4-10H2,1H3,(H,27,28)
PDB

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UniChem
Article
US Patent
n/an/a 15n/an/an/an/a7.425



Columbia University

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US10072016 (2018)


Article DOI: 10.1021/jm050333c
BindingDB Entry DOI: 10.7270/Q2QJ7KBT
More data for this
Ligand-Target Pair
Transthyretin


(Homo sapiens (Human))
BDBM249482
PNG
(US10072016, Compound 81 | US10407433, Compound 81 ...)
Show SMILES CC(=O)N1CCc2c(C1)[nH]nc2C(=O)N1CCC(CC1)c1ccc(F)c(F)c1C(F)(F)F
Show InChI InChI=1S/C21H21F5N4O2/c1-11(31)30-9-6-14-16(10-30)27-28-19(14)20(32)29-7-4-12(5-8-29)13-2-3-15(22)18(23)17(13)21(24,25)26/h2-3,12H,4-10H2,1H3,(H,27,28)
PDB

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US Patent
n/an/a 15n/an/an/an/a7.425



Columbia University

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US10072016 (2018)


Article DOI: 10.1021/jm050333c
BindingDB Entry DOI: 10.7270/Q2QJ7KBT
More data for this
Ligand-Target Pair
Transthyretin


(Homo sapiens (Human))
BDBM249512
PNG
(US10072016, Compound 110 | US10407433, Compound 11...)
Show SMILES Fc1ccc(C2CCN(CC2)C(=O)c2n[nH]c3CN(Cc23)C#N)c(c1F)C(F)(F)F
Show InChI InChI=1S/C19H16F5N5O/c20-13-2-1-11(15(16(13)21)19(22,23)24)10-3-5-29(6-4-10)18(30)17-12-7-28(9-25)8-14(12)26-27-17/h1-2,10H,3-8H2,(H,26,27)
PDB

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n/an/a 15.4n/an/an/an/a7.425



Columbia University

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US10072016 (2018)


Article DOI: 10.1021/jm050333c
BindingDB Entry DOI: 10.7270/Q2QJ7KBT
More data for this
Ligand-Target Pair
Transthyretin


(Homo sapiens (Human))
BDBM249480
PNG
(US10072016, Compound 78 | US10407433, Compound 78 ...)
Show SMILES Fc1cccc(C2CCN(CC2)C(=O)c2n[nH]c3CN(CCc23)C2COC2)c1C(F)(F)F
Show InChI InChI=1S/C22H24F4N4O2/c23-17-3-1-2-15(19(17)22(24,25)26)13-4-7-29(8-5-13)21(31)20-16-6-9-30(14-11-32-12-14)10-18(16)27-28-20/h1-3,13-14H,4-12H2,(H,27,28)
PDB

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n/an/a 15.8n/an/an/an/a7.425



Columbia University

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US10072016 (2018)


Article DOI: 10.1021/jm050333c
BindingDB Entry DOI: 10.7270/Q2QJ7KBT
More data for this
Ligand-Target Pair
Transthyretin


(Homo sapiens (Human))
BDBM249464
PNG
(US10072016, Compound 63 | US10407433, Compound 63 ...)
Show SMILES CC(=O)N1CCc2c(C1)[nH]nc2C(=O)N1CCC(CC1)c1cccc(F)c1C(F)(F)F
Show InChI InChI=1S/C21H22F4N4O2/c1-12(30)29-10-7-15-17(11-29)26-27-19(15)20(31)28-8-5-13(6-9-28)14-3-2-4-16(22)18(14)21(23,24)25/h2-4,13H,5-11H2,1H3,(H,26,27)
PDB

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n/an/a 16n/an/an/an/a7.425



Columbia University

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US10072016 (2018)


Article DOI: 10.1021/jm050333c
BindingDB Entry DOI: 10.7270/Q2QJ7KBT
More data for this
Ligand-Target Pair
Transthyretin


(Homo sapiens (Human))
BDBM249489
PNG
(US10072016, Compound 87 | US10407433, Compound 87 ...)
Show SMILES CCN1CCc2[nH]nc(C(=O)N3CCC(CC3)c3ccc(F)c(F)c3C(F)(F)F)c2C1
Show InChI InChI=1S/C21H23F5N4O/c1-2-29-8-7-16-14(11-29)19(28-27-16)20(31)30-9-5-12(6-10-30)13-3-4-15(22)18(23)17(13)21(24,25)26/h3-4,12H,2,5-11H2,1H3,(H,27,28)
PDB

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n/an/a 16.4n/an/an/an/a7.425



Columbia University

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US10072016 (2018)


Article DOI: 10.1021/jm050333c
BindingDB Entry DOI: 10.7270/Q2QJ7KBT
More data for this
Ligand-Target Pair
Transthyretin


(Homo sapiens (Human))
BDBM249529
PNG
(US10072016, Compound 127 | US10407433, Compound 12...)
Show SMILES COCCN1CCc2[nH]nc(C(=O)N3CCC(CC3)c3cc(F)cc(F)c3C(F)(F)F)c2C1
Show InChI InChI=1S/C22H25F5N4O2/c1-33-9-8-30-5-4-18-16(12-30)20(29-28-18)21(32)31-6-2-13(3-7-31)15-10-14(23)11-17(24)19(15)22(25,26)27/h10-11,13H,2-9,12H2,1H3,(H,28,29)
PDB

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n/an/a 17n/an/an/an/a7.425



Columbia University

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US10072016 (2018)


Article DOI: 10.1021/jm050333c
BindingDB Entry DOI: 10.7270/Q2QJ7KBT
More data for this
Ligand-Target Pair
Transthyretin


(Homo sapiens (Human))
BDBM249490
PNG
(US10072016, Compound 88 | US10407433, Compound 88 ...)
Show SMILES Fc1ccc(C2CCN(CC2)C(=O)c2n[nH]c3CCN(CC4CC4)Cc23)c(c1F)C(F)(F)F
Show InChI InChI=1S/C23H25F5N4O/c24-17-4-3-15(19(20(17)25)23(26,27)28)14-5-9-32(10-6-14)22(33)21-16-12-31(11-13-1-2-13)8-7-18(16)29-30-21/h3-4,13-14H,1-2,5-12H2,(H,29,30)
PDB

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n/an/a 18n/an/an/an/a7.425



Columbia University

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US10072016 (2018)


Article DOI: 10.1021/jm050333c
BindingDB Entry DOI: 10.7270/Q2QJ7KBT
More data for this
Ligand-Target Pair
Transthyretin


(Homo sapiens (Human))
BDBM249531
PNG
(US10072016, Compound 129 | US10407433, Compound 12...)
Show SMILES Fc1cc(F)c(c(c1)C1CCN(CC1)C(=O)c1n[nH]c2CCN(CCC(F)(F)F)Cc12)C(F)(F)F
Show InChI InChI=1S/C22H22F8N4O/c23-13-9-14(18(16(24)10-13)22(28,29)30)12-1-6-34(7-2-12)20(35)19-15-11-33(8-4-21(25,26)27)5-3-17(15)31-32-19/h9-10,12H,1-8,11H2,(H,31,32)
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n/an/a 19.5n/an/an/an/a7.425



Columbia University

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US10072016 (2018)


Article DOI: 10.1021/jm050333c
BindingDB Entry DOI: 10.7270/Q2QJ7KBT
More data for this
Ligand-Target Pair
Transthyretin


(Homo sapiens (Human))
BDBM249477
PNG
(US10072016, Compound 76 | US10407433, Compound 76 ...)
Show SMILES Fc1cccc(C2CCN(CC2)C(=O)c2n[nH]c3CN(CCC(F)(F)F)CCc23)c1C(F)(F)F
Show InChI InChI=1S/C22H23F7N4O/c23-16-3-1-2-14(18(16)22(27,28)29)13-4-9-33(10-5-13)20(34)19-15-6-8-32(11-7-21(24,25)26)12-17(15)30-31-19/h1-3,13H,4-12H2,(H,30,31)
PDB

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US Patent
n/an/a 19.7n/an/an/an/a7.425



Columbia University

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US10072016 (2018)


Article DOI: 10.1021/jm050333c
BindingDB Entry DOI: 10.7270/Q2QJ7KBT
More data for this
Ligand-Target Pair
Transthyretin


(Homo sapiens (Human))
BDBM249562
PNG
(US10072016, Compound 160 | US10407433, Compound 16...)
Show SMILES Fc1ccc(C2CCN(CC2)C(=O)c2nnc3ccc(cn23)C#N)c(c1)C(F)(F)F
Show InChI InChI=1S/C20H15F4N5O/c21-14-2-3-15(16(9-14)20(22,23)24)13-5-7-28(8-6-13)19(30)18-27-26-17-4-1-12(10-25)11-29(17)18/h1-4,9,11,13H,5-8H2
PDB

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US Patent
n/an/a 19.8n/an/an/an/a7.425



Columbia University

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US10072016 (2018)


Article DOI: 10.1021/jm050333c
BindingDB Entry DOI: 10.7270/Q2QJ7KBT
More data for this
Ligand-Target Pair
Transthyretin


(Homo sapiens (Human))
BDBM249465
PNG
(US10072016, Compound 64 | US10407433, Compound 64 ...)
Show SMILES CS(=O)(=O)N1CCc2[nH]nc(C(=O)N3CCC(CC3)c3cccc(F)c3C(F)(F)F)c2C1
Show InChI InChI=1S/C20H22F4N4O3S/c1-32(30,31)28-10-7-16-14(11-28)18(26-25-16)19(29)27-8-5-12(6-9-27)13-3-2-4-15(21)17(13)20(22,23)24/h2-4,12H,5-11H2,1H3,(H,25,26)
PDB

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n/an/a 20.6n/an/an/an/a7.425



Columbia University

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US10072016 (2018)


Article DOI: 10.1021/jm050333c
BindingDB Entry DOI: 10.7270/Q2QJ7KBT
More data for this
Ligand-Target Pair
Transthyretin


(Homo sapiens (Human))
BDBM249543
PNG
(US10072016, Compound 141 | US10407433, Compound 14...)
Show SMILES CS(=O)(=O)N1CCc2[nH]nc(C(=O)N3CCC(CC3)c3cc(F)ccc3C(F)(F)F)c2C1
Show InChI InChI=1S/C20H22F4N4O3S/c1-32(30,31)28-9-6-17-15(11-28)18(26-25-17)19(29)27-7-4-12(5-8-27)14-10-13(21)2-3-16(14)20(22,23)24/h2-3,10,12H,4-9,11H2,1H3,(H,25,26)
PDB

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n/an/a 20.8n/an/an/an/a7.425



Columbia University

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US10072016 (2018)


Article DOI: 10.1021/jm050333c
BindingDB Entry DOI: 10.7270/Q2QJ7KBT
More data for this
Ligand-Target Pair
Transthyretin


(Homo sapiens (Human))
BDBM249537
PNG
(US10072016, Compound 135 | US10407433, Compound 13...)
Show SMILES Fc1cc(F)c(c(c1)C1CCN(CC1)C(=O)c1n[nH]c2CN(CCc12)C1COC1)C(F)(F)F
Show InChI InChI=1S/C22H23F5N4O2/c23-13-7-16(19(17(24)8-13)22(25,26)27)12-1-4-30(5-2-12)21(32)20-15-3-6-31(14-10-33-11-14)9-18(15)28-29-20/h7-8,12,14H,1-6,9-11H2,(H,28,29)
PDB

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n/an/a 21n/an/an/an/a7.425



Columbia University

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US10072016 (2018)


Article DOI: 10.1021/jm050333c
BindingDB Entry DOI: 10.7270/Q2QJ7KBT
More data for this
Ligand-Target Pair
Transthyretin


(Homo sapiens (Human))
BDBM249522
PNG
(US10072016, Compound 120 | US10407433, Compound 12...)
Show SMILES Fc1ccc(C2CCN(CC2)C(=O)c2n[nH]c3CN(CCc23)C#N)c(c1F)C(F)(F)F
Show InChI InChI=1S/C20H18F5N5O/c21-14-2-1-12(16(17(14)22)20(23,24)25)11-3-7-30(8-4-11)19(31)18-13-5-6-29(10-26)9-15(13)27-28-18/h1-2,11H,3-9H2,(H,27,28)
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n/an/a 21n/an/an/an/a7.425



Columbia University

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US10072016 (2018)


Article DOI: 10.1021/jm050333c
BindingDB Entry DOI: 10.7270/Q2QJ7KBT
More data for this
Ligand-Target Pair
Transthyretin


(Homo sapiens (Human))
BDBM249506
PNG
(US10072016, Compound 104 | US10407433, Compound 10...)
Show SMILES Fc1ccc(C2CCN(CC2)C(=O)c2n[nH]c3CN(Cc23)C(=O)c2cccnc2)c(c1F)C(F)(F)F
Show InChI InChI=1S/C24H20F5N5O2/c25-17-4-3-15(19(20(17)26)24(27,28)29)13-5-8-33(9-6-13)23(36)21-16-11-34(12-18(16)31-32-21)22(35)14-2-1-7-30-10-14/h1-4,7,10,13H,5-6,8-9,11-12H2,(H,31,32)
PDB

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n/an/a 21.8n/an/an/an/a7.425



Columbia University

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US10072016 (2018)


Article DOI: 10.1021/jm050333c
BindingDB Entry DOI: 10.7270/Q2QJ7KBT
More data for this
Ligand-Target Pair
Transthyretin


(Homo sapiens (Human))
BDBM249542
PNG
(US10072016, Compound 140 | US10407433, Compound 14...)
Show SMILES CC(=O)N1CCc2c(C1)[nH]nc2C(=O)N1CCC(CC1)c1cc(F)ccc1C(F)(F)F
Show InChI InChI=1S/C21H22F4N4O2/c1-12(30)29-9-6-15-18(11-29)26-27-19(15)20(31)28-7-4-13(5-8-28)16-10-14(22)2-3-17(16)21(23,24)25/h2-3,10,13H,4-9,11H2,1H3,(H,26,27)
PDB

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n/an/a 21.9n/an/an/an/a7.425



Columbia University

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US10072016 (2018)


Article DOI: 10.1021/jm050333c
BindingDB Entry DOI: 10.7270/Q2QJ7KBT
More data for this
Ligand-Target Pair
Transthyretin


(Homo sapiens (Human))
BDBM249513
PNG
(US10072016, Compound 111 | US10407433, Compound 11...)
Show SMILES CCN1CCc2c(C1)[nH]nc2C(=O)N1CCC(CC1)c1ccc(F)c(F)c1C(F)(F)F
Show InChI InChI=1S/C21H23F5N4O/c1-2-29-8-7-14-16(11-29)27-28-19(14)20(31)30-9-5-12(6-10-30)13-3-4-15(22)18(23)17(13)21(24,25)26/h3-4,12H,2,5-11H2,1H3,(H,27,28)
PDB

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n/an/a 22.1n/an/an/an/a7.425



Columbia University

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US10072016 (2018)


Article DOI: 10.1021/jm050333c
BindingDB Entry DOI: 10.7270/Q2QJ7KBT
More data for this
Ligand-Target Pair
Transthyretin


(Homo sapiens (Human))
BDBM249489
PNG
(US10072016, Compound 87 | US10407433, Compound 87 ...)
Show SMILES CCN1CCc2[nH]nc(C(=O)N3CCC(CC3)c3ccc(F)c(F)c3C(F)(F)F)c2C1
Show InChI InChI=1S/C21H23F5N4O/c1-2-29-8-7-16-14(11-29)19(28-27-16)20(31)30-9-5-12(6-10-30)13-3-4-15(22)18(23)17(13)21(24,25)26/h3-4,12H,2,5-11H2,1H3,(H,27,28)
PDB

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n/an/a 22.2n/an/an/an/a7.425



Columbia University

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US10072016 (2018)


Article DOI: 10.1021/jm050333c
BindingDB Entry DOI: 10.7270/Q2QJ7KBT
More data for this
Ligand-Target Pair
Transthyretin


(Homo sapiens (Human))
BDBM249487
PNG
(US10072016, Compound 85 | US10407433, Compound 85 ...)
Show SMILES CC(C)C(=O)N1Cc2[nH]nc(C(=O)N3CCC(CC3)c3ccc(F)c(F)c3C(F)(F)F)c2C1
Show InChI InChI=1S/C22H23F5N4O2/c1-11(2)20(32)31-9-14-16(10-31)28-29-19(14)21(33)30-7-5-12(6-8-30)13-3-4-15(23)18(24)17(13)22(25,26)27/h3-4,11-12H,5-10H2,1-2H3,(H,28,29)
PDB

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n/an/a 22.4n/an/an/an/a7.425



Columbia University

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US10072016 (2018)


Article DOI: 10.1021/jm050333c
BindingDB Entry DOI: 10.7270/Q2QJ7KBT
More data for this
Ligand-Target Pair
Transthyretin


(Homo sapiens (Human))
BDBM249541
PNG
(US10072016, Compound 139 | US10407433, Compound 13...)
Show SMILES CNC(=O)N1CCc2c(C1)[nH]nc2C(=O)N1CCC(CC1)c1cc(F)cc(F)c1C(F)(F)F
Show InChI InChI=1S/C21H22F5N5O2/c1-27-20(33)31-7-4-13-16(10-31)28-29-18(13)19(32)30-5-2-11(3-6-30)14-8-12(22)9-15(23)17(14)21(24,25)26/h8-9,11H,2-7,10H2,1H3,(H,27,33)(H,28,29)
PDB

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n/an/a 22.8n/an/an/an/a7.425



Columbia University

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US10072016 (2018)


Article DOI: 10.1021/jm050333c
BindingDB Entry DOI: 10.7270/Q2QJ7KBT
More data for this
Ligand-Target Pair
Transthyretin


(Homo sapiens (Human))
BDBM249544
PNG
(US10072016, Compound 142 | US10407433, Compound 14...)
Show SMILES Fc1ccc(c(c1)C1CCN(CC1)C(=O)c1nnc2ccc(cn12)C#N)C(F)(F)F
Show InChI InChI=1S/C20H15F4N5O/c21-14-2-3-16(20(22,23)24)15(9-14)13-5-7-28(8-6-13)19(30)18-27-26-17-4-1-12(10-25)11-29(17)18/h1-4,9,11,13H,5-8H2
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n/an/a 23.2n/an/an/an/a7.425



Columbia University

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US10072016 (2018)


Article DOI: 10.1021/jm050333c
BindingDB Entry DOI: 10.7270/Q2QJ7KBT
More data for this
Ligand-Target Pair
Transthyretin


(Homo sapiens (Human))
BDBM249551
PNG
(US10072016, Compound 149 | US10407433, Compound 14...)
Show SMILES Fc1cccc(C2CCN(CC2)C(=O)c2n[nH]c3CN(CCc23)C2COC2)c1Cl
Show InChI InChI=1S/C21H24ClFN4O2/c22-19-15(2-1-3-17(19)23)13-4-7-26(8-5-13)21(28)20-16-6-9-27(14-11-29-12-14)10-18(16)24-25-20/h1-3,13-14H,4-12H2,(H,24,25)
PDB

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n/an/a 23.4n/an/an/an/a7.425



Columbia University

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US10072016 (2018)


Article DOI: 10.1021/jm050333c
BindingDB Entry DOI: 10.7270/Q2QJ7KBT
More data for this
Ligand-Target Pair
Transthyretin


(Homo sapiens (Human))
BDBM249552
PNG
(US10072016, Compound 150 | US10407433, Compound 15...)
Show SMILES CC(=O)N1CCc2c(C1)[nH]nc2C(=O)N1CCC(CC1)c1cccc(F)c1Cl
Show InChI InChI=1S/C20H22ClFN4O2/c1-12(27)26-10-7-15-17(11-26)23-24-19(15)20(28)25-8-5-13(6-9-25)14-3-2-4-16(22)18(14)21/h2-4,13H,5-11H2,1H3,(H,23,24)
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n/an/a 23.7n/an/an/an/a7.425



Columbia University

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US10072016 (2018)


Article DOI: 10.1021/jm050333c
BindingDB Entry DOI: 10.7270/Q2QJ7KBT
More data for this
Ligand-Target Pair
Transthyretin


(Homo sapiens (Human))
BDBM249518
PNG
(US10072016, Compound 116 | US10407433, Compound 11...)
Show SMILES COC(=O)N1CCc2c(C1)[nH]nc2C(=O)N1CCC(CC1)c1ccc(F)c(F)c1C(F)(F)F
Show InChI InChI=1S/C21H21F5N4O3/c1-33-20(32)30-9-6-13-15(10-30)27-28-18(13)19(31)29-7-4-11(5-8-29)12-2-3-14(22)17(23)16(12)21(24,25)26/h2-3,11H,4-10H2,1H3,(H,27,28)
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n/an/a 23.7n/an/an/an/a7.425



Columbia University

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US10072016 (2018)


Article DOI: 10.1021/jm050333c
BindingDB Entry DOI: 10.7270/Q2QJ7KBT
More data for this
Ligand-Target Pair
Transthyretin


(Homo sapiens (Human))
BDBM249499
PNG
(US10072016, Compound 97 | US10407433, Compound 97 ...)
Show SMILES Fc1ccc(C2CCN(CC2)C(=O)c2n[nH]c3CN(CC4CC4)Cc23)c(c1F)C(F)(F)F
Show InChI InChI=1S/C22H23F5N4O/c23-16-4-3-14(18(19(16)24)22(25,26)27)13-5-7-31(8-6-13)21(32)20-15-10-30(9-12-1-2-12)11-17(15)28-29-20/h3-4,12-13H,1-2,5-11H2,(H,28,29)
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n/an/a 24n/an/an/an/a7.425



Columbia University

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US10072016 (2018)


Article DOI: 10.1021/jm050333c
BindingDB Entry DOI: 10.7270/Q2QJ7KBT
More data for this
Ligand-Target Pair
Transthyretin


(Homo sapiens (Human))
BDBM249539
PNG
(US10072016, Compound 137 | US10407433, Compound 13...)
Show SMILES Fc1cc(F)c(c(c1)C1CCN(CC1)C(=O)c1n[nH]c2CN(CC(F)(F)F)CCc12)C(F)(F)F
Show InChI InChI=1S/C21H20F8N4O/c22-12-7-14(17(15(23)8-12)21(27,28)29)11-1-5-33(6-2-11)19(34)18-13-3-4-32(10-20(24,25)26)9-16(13)30-31-18/h7-8,11H,1-6,9-10H2,(H,30,31)
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n/an/a 24.2n/an/an/an/a7.425



Columbia University

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US10072016 (2018)


Article DOI: 10.1021/jm050333c
BindingDB Entry DOI: 10.7270/Q2QJ7KBT
More data for this
Ligand-Target Pair
Transthyretin


(Homo sapiens (Human))
BDBM249540
PNG
(US10072016, Compound 138 | US10407433, Compound 13...)
Show SMILES COC(=O)N1CCc2[nH]nc(C(=O)N3CCC(CC3)c3cc(F)cc(F)c3C(F)(F)F)c2C1
Show InChI InChI=1S/C21H21F5N4O3/c1-33-20(32)30-7-4-16-14(10-30)18(28-27-16)19(31)29-5-2-11(3-6-29)13-8-12(22)9-15(23)17(13)21(24,25)26/h8-9,11H,2-7,10H2,1H3,(H,27,28)
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n/an/a 24.4n/an/an/an/a7.425



Columbia University

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US10072016 (2018)


Article DOI: 10.1021/jm050333c
BindingDB Entry DOI: 10.7270/Q2QJ7KBT
More data for this
Ligand-Target Pair
Transthyretin


(Homo sapiens (Human))
BDBM249526
PNG
(US10072016, Compound 124 | US10407433, Compound 12...)
Show SMILES COCCN1CCc2c(C1)[nH]nc2C(=O)N1CCC(CC1)c1ccc(F)c(F)c1C(F)(F)F
Show InChI InChI=1S/C22H25F5N4O2/c1-33-11-10-30-7-6-15-17(12-30)28-29-20(15)21(32)31-8-4-13(5-9-31)14-2-3-16(23)19(24)18(14)22(25,26)27/h2-3,13H,4-12H2,1H3,(H,28,29)
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n/an/a 24.9n/an/an/an/a7.425



Columbia University

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US10072016 (2018)


Article DOI: 10.1021/jm050333c
BindingDB Entry DOI: 10.7270/Q2QJ7KBT
More data for this
Ligand-Target Pair
Transthyretin


(Homo sapiens (Human))
BDBM249549
PNG
(US10072016, Compound 147 | US10407433, Compound 14...)
Show SMILES COC(=O)N1CCc2c(C1)[nH]nc2C(=O)N1CCC(CC1)c1cccc(F)c1Cl
Show InChI InChI=1S/C20H22ClFN4O3/c1-29-20(28)26-10-7-14-16(11-26)23-24-18(14)19(27)25-8-5-12(6-9-25)13-3-2-4-15(22)17(13)21/h2-4,12H,5-11H2,1H3,(H,23,24)
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n/an/a 25.5n/an/an/an/a7.425



Columbia University

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US10072016 (2018)


Article DOI: 10.1021/jm050333c
BindingDB Entry DOI: 10.7270/Q2QJ7KBT
More data for this
Ligand-Target Pair
Transthyretin


(Homo sapiens (Human))
BDBM249563
PNG
(US10072016, Compound 161 | US10407433, Compound 16...)
Show SMILES FC(F)(F)c1ccc(Cl)cc1C1CCN(CC1)C(=O)c1nnc2ccc(cn12)C#N
Show InChI InChI=1S/C20H15ClF3N5O/c21-14-2-3-16(20(22,23)24)15(9-14)13-5-7-28(8-6-13)19(30)18-27-26-17-4-1-12(10-25)11-29(17)18/h1-4,9,11,13H,5-8H2
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n/an/a 25.8n/an/an/an/a7.425



Columbia University

US Patent


Assay Description
Untagged human RBP4 purified from urine of tubular proteinuria patients was purchased from Fitzgerald Industries International. It was biotinylated u...


US Patent US10072016 (2018)


Article DOI: 10.1021/jm050333c
BindingDB Entry DOI: 10.7270/Q2QJ7KBT
More data for this
Ligand-Target Pair
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