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Compile Data Set for Download or QSAR

Found 1918 hits of ic50 for UniProtKB: P06401   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Progesterone receptor


(Homo sapiens (Human))
BDBM50409115
PNG
(LONAPRISAN)
Show SMILES CC(=O)c1ccc(cc1)[C@H]1C[C@@]2(C)[C@@H](CC[C@@]2(O)C(F)(F)C(F)(F)F)[C@@H]2CCC3=CC(=O)CCC3=C12
Show InChI InChI=1S/C28H29F5O3/c1-15(34)16-3-5-17(6-4-16)22-14-25(2)23(11-12-26(25,36)27(29,30)28(31,32)33)21-9-7-18-13-19(35)8-10-20(18)24(21)22/h3-6,13,21-23,36H,7-12,14H2,1-2H3/t21-,22+,23-,25-,26-/m0/s1
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n/an/a 0.00250n/an/an/an/an/an/a



Schering AG

Curated by ChEMBL


Assay Description
In vitro antagonist potency in transactivation assay in neuroblastoma cells expressing human PR-B progesterone receptor


J Med Chem 43: 5010-6 (2001)


Article DOI: 10.1021/jm001000c
BindingDB Entry DOI: 10.7270/Q2VT1T90
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50409115
PNG
(LONAPRISAN)
Show SMILES CC(=O)c1ccc(cc1)[C@H]1C[C@@]2(C)[C@@H](CC[C@@]2(O)C(F)(F)C(F)(F)F)[C@@H]2CCC3=CC(=O)CCC3=C12
Show InChI InChI=1S/C28H29F5O3/c1-15(34)16-3-5-17(6-4-16)22-14-25(2)23(11-12-26(25,36)27(29,30)28(31,32)33)21-9-7-18-13-19(35)8-10-20(18)24(21)22/h3-6,13,21-23,36H,7-12,14H2,1-2H3/t21-,22+,23-,25-,26-/m0/s1
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n/an/a 0.00360n/an/an/an/an/an/a



Schering AG

Curated by ChEMBL


Assay Description
In vitro antagonist potency in transactivation assay in neuroblastoma cells expressing human PR-A progesterone receptor


J Med Chem 43: 5010-6 (2001)


Article DOI: 10.1021/jm001000c
BindingDB Entry DOI: 10.7270/Q2VT1T90
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM18627
PNG
((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
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n/an/a 0.0210n/an/an/an/an/an/a



University of Graz

Curated by ChEMBL


Assay Description
Antagonist activity at progesterone receptor in human T47D-C124 cells transfected with luciferase gene linked to MMTV promoter assessed as inhibition...


J Med Chem 52: 1268-74 (2010)


Article DOI: 10.1021/jm800985z
BindingDB Entry DOI: 10.7270/Q27S7PPM
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Progesterone receptor


(Homo sapiens (Human))
BDBM50292753
PNG
(17beta-Hydroxy-11beta-[4-(N-methylpropylamino)-phe...)
Show SMILES CCCN(C)c1ccc(cc1)[C@H]1C[C@@]2(C)[C@@H](CC[C@@]2(O)C#CC)[C@@H]2CCC3=CC(=O)CCC3=C12
Show InChI InChI=1S/C31H39NO2/c1-5-16-31(34)17-15-28-26-13-9-22-19-24(33)12-14-25(22)29(26)27(20-30(28,31)3)21-7-10-23(11-8-21)32(4)18-6-2/h7-8,10-11,19,26-28,34H,6,9,12-15,17-18,20H2,1-4H3/t26-,27+,28-,30-,31-/m0/s1
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n/an/a 0.0250n/an/an/an/an/an/a



University of Graz

Curated by ChEMBL


Assay Description
Antagonist activity at progesterone receptor in human T47D-C124 cells transfected with luciferase gene linked to MMTV promoter assessed as inhibition...


J Med Chem 52: 1268-74 (2010)


Article DOI: 10.1021/jm800985z
BindingDB Entry DOI: 10.7270/Q27S7PPM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM18627
PNG
((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
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n/an/a 0.0250n/an/an/an/an/an/a



Schering AG

Curated by ChEMBL


Assay Description
In vitro antagonist potency in transactivation assay in neuroblastoma cells expressing human PR-B progesterone receptor


J Med Chem 43: 5010-6 (2001)


Article DOI: 10.1021/jm001000c
BindingDB Entry DOI: 10.7270/Q2VT1T90
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Progesterone receptor


(Homo sapiens (Human))
BDBM18627
PNG
((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
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n/an/a 0.0280n/an/an/an/an/an/a



Schering AG

Curated by ChEMBL


Assay Description
In vitro antgonist potency in transactivation assay in neuroblastoma cells expressing human PR-A progesterone receptor


J Med Chem 43: 5010-6 (2001)


Article DOI: 10.1021/jm001000c
BindingDB Entry DOI: 10.7270/Q2VT1T90
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Progesterone receptor


(Homo sapiens (Human))
BDBM18627
PNG
((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
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n/an/a 0.0450n/an/an/an/an/an/a



University of Graz

Curated by ChEMBL


Assay Description
Antagonist activity at progesterone receptor in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity after 4...


J Med Chem 52: 1268-74 (2010)


Article DOI: 10.1021/jm800985z
BindingDB Entry DOI: 10.7270/Q27S7PPM
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Progesterone receptor


(Homo sapiens (Human))
BDBM18627
PNG
((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
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n/an/a 0.0500n/an/an/an/an/an/a



University of Quebec at Trois-Rivieres

Curated by ChEMBL


Assay Description
Antiprogestagenic activity at progesterone receptor in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity


Bioorg Med Chem 18: 1891-8 (2010)


Article DOI: 10.1016/j.bmc.2010.01.048
BindingDB Entry DOI: 10.7270/Q25D8SS5
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Progesterone receptor


(Homo sapiens (Human))
BDBM18627
PNG
((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
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n/an/a 0.0540n/an/an/an/an/an/a



RTI International

Curated by ChEMBL


Assay Description
Antagonist activity at progesterone receptor expressed in human T47D cells assessed as inhibition of promegestone-induced alkaline phosphatase activi...


Bioorg Med Chem Lett 17: 5754-7 (2007)


Article DOI: 10.1016/j.bmcl.2007.08.064
BindingDB Entry DOI: 10.7270/Q2Z03905
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Progesterone receptor


(Homo sapiens (Human))
BDBM50292757
PNG
(17beta-Hydroxy-11beta-[4-(6-hydroxy-N-methylhexyla...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)CCCCCCO
Show InChI InChI=1S/C34H45NO3/c1-4-18-34(38)19-17-31-29-15-11-25-22-27(37)14-16-28(25)32(29)30(23-33(31,34)2)24-9-12-26(13-10-24)35(3)20-7-5-6-8-21-36/h9-10,12-13,22,29-31,36,38H,5-8,11,14-17,19-21,23H2,1-3H3/t29-,30+,31-,33-,34-/m0/s1
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n/an/a 0.0600n/an/an/an/an/an/a



University of Graz

Curated by ChEMBL


Assay Description
Antagonist activity at progesterone receptor in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity after 4...


J Med Chem 52: 1268-74 (2010)


Article DOI: 10.1021/jm800985z
BindingDB Entry DOI: 10.7270/Q27S7PPM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50292757
PNG
(17beta-Hydroxy-11beta-[4-(6-hydroxy-N-methylhexyla...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)CCCCCCO
Show InChI InChI=1S/C34H45NO3/c1-4-18-34(38)19-17-31-29-15-11-25-22-27(37)14-16-28(25)32(29)30(23-33(31,34)2)24-9-12-26(13-10-24)35(3)20-7-5-6-8-21-36/h9-10,12-13,22,29-31,36,38H,5-8,11,14-17,19-21,23H2,1-3H3/t29-,30+,31-,33-,34-/m0/s1
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n/an/a 0.0710n/an/an/an/an/an/a



University of Graz

Curated by ChEMBL


Assay Description
Antagonist activity at progesterone receptor in human T47D-C124 cells transfected with luciferase gene linked to MMTV promoter assessed as inhibition...


J Med Chem 52: 1268-74 (2010)


Article DOI: 10.1021/jm800985z
BindingDB Entry DOI: 10.7270/Q27S7PPM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50292758
PNG
(17beta-Hydroxy-11beta-{4-[5-(1,3-dioxol-2-yl)-N-me...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)CCCCCC1OCCO1
Show InChI InChI=1S/C36H47NO4/c1-4-18-36(39)19-17-32-30-15-11-26-23-28(38)14-16-29(26)34(30)31(24-35(32,36)2)25-9-12-27(13-10-25)37(3)20-7-5-6-8-33-40-21-22-41-33/h9-10,12-13,23,30-33,39H,5-8,11,14-17,19-22,24H2,1-3H3/t30-,31+,32-,35-,36-/m0/s1
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n/an/a 0.0730n/an/an/an/an/an/a



University of Graz

Curated by ChEMBL


Assay Description
Antagonist activity at progesterone receptor in human T47D-C124 cells transfected with luciferase gene linked to MMTV promoter assessed as inhibition...


J Med Chem 52: 1268-74 (2010)


Article DOI: 10.1021/jm800985z
BindingDB Entry DOI: 10.7270/Q27S7PPM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50292750
PNG
(17beta-Hydroxy-11beta-[4-(methylamino)-phenyl]-17a...)
Show SMILES CNc1ccc(cc1)[C@H]1C[C@@]2(C)[C@@H](CC[C@@]2(O)C#CC)[C@@H]2CCC3=CC(=O)CCC3=C12
Show InChI InChI=1S/C28H33NO2/c1-4-14-28(31)15-13-25-23-11-7-19-16-21(30)10-12-22(19)26(23)24(17-27(25,28)2)18-5-8-20(29-3)9-6-18/h5-6,8-9,16,23-25,29,31H,7,10-13,15,17H2,1-3H3/t23-,24+,25-,27-,28-/m0/s1
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University of Graz

Curated by ChEMBL


Assay Description
Antagonist activity at progesterone receptor in human T47D-C124 cells transfected with luciferase gene linked to MMTV promoter assessed as inhibition...


J Med Chem 52: 1268-74 (2010)


Article DOI: 10.1021/jm800985z
BindingDB Entry DOI: 10.7270/Q27S7PPM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50195153
PNG
((8S,11R,13S,14S,17S)-17-hydroxy-11-(4-methoxy-phen...)
Show SMILES COc1ccc(cc1)[C@H]1C[C@@]2(C)[C@@H](CC[C@@]2(O)C#CC)[C@@H]2CCC3=CC(=O)CCC3=C12
Show InChI InChI=1S/C28H32O3/c1-4-14-28(30)15-13-25-23-11-7-19-16-20(29)8-12-22(19)26(23)24(17-27(25,28)2)18-5-9-21(31-3)10-6-18/h5-6,9-10,16,23-25,30H,7-8,11-13,15,17H2,1-3H3/t23-,24+,25-,27-,28-/m0/s1
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n/an/a 0.0950n/an/an/an/an/an/a



University of Graz

Curated by ChEMBL


Assay Description
Antagonist activity at progesterone receptor in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity after 4...


J Med Chem 52: 1268-74 (2010)


Article DOI: 10.1021/jm800985z
BindingDB Entry DOI: 10.7270/Q27S7PPM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM18627
PNG
((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
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n/an/a 0.100n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...


Bioorg Med Chem Lett 12: 3487-90 (2002)


Article DOI: 10.1016/s0960-894x(02)00746-1
BindingDB Entry DOI: 10.7270/Q2R210RC
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Progesterone receptor


(Homo sapiens (Human))
BDBM50292756
PNG
(17beta-Hydroxy-11beta-[4-(3-hydroxy-N-methypropyla...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)CCCO
Show InChI InChI=1S/C31H39NO3/c1-4-15-31(35)16-14-28-26-12-8-22-19-24(34)11-13-25(22)29(26)27(20-30(28,31)2)21-6-9-23(10-7-21)32(3)17-5-18-33/h6-7,9-10,19,26-28,33,35H,5,8,11-14,16-18,20H2,1-3H3/t26-,27+,28-,30-,31-/m0/s1
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n/an/a 0.105n/an/an/an/an/an/a



University of Graz

Curated by ChEMBL


Assay Description
Antagonist activity at progesterone receptor in human T47D-C124 cells transfected with luciferase gene linked to MMTV promoter assessed as inhibition...


J Med Chem 52: 1268-74 (2010)


Article DOI: 10.1021/jm800985z
BindingDB Entry DOI: 10.7270/Q27S7PPM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50292756
PNG
(17beta-Hydroxy-11beta-[4-(3-hydroxy-N-methypropyla...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)CCCO
Show InChI InChI=1S/C31H39NO3/c1-4-15-31(35)16-14-28-26-12-8-22-19-24(34)11-13-25(22)29(26)27(20-30(28,31)2)21-6-9-23(10-7-21)32(3)17-5-18-33/h6-7,9-10,19,26-28,33,35H,5,8,11-14,16-18,20H2,1-3H3/t26-,27+,28-,30-,31-/m0/s1
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n/an/a 0.120n/an/an/an/an/an/a



University of Graz

Curated by ChEMBL


Assay Description
Antagonist activity at progesterone receptor in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity after 4...


J Med Chem 52: 1268-74 (2010)


Article DOI: 10.1021/jm800985z
BindingDB Entry DOI: 10.7270/Q27S7PPM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM18627
PNG
((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
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n/an/a 0.130n/an/an/an/an/an/a



Women's Health Research Institute

Curated by ChEMBL


Assay Description
Antagonist activity against progesterone receptor (PR) in an alkaline phosphatase assay in the T47D human breast carcinoma cell line


J Med Chem 45: 4379-82 (2002)


Article DOI: 10.1021/jm025555e
BindingDB Entry DOI: 10.7270/Q22F7P5W
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Progesterone receptor


(Homo sapiens (Human))
BDBM50375439
PNG
(CHEMBL410304)
Show SMILES C[C@]12C[C@@H](C3=C4CCC(=O)C=C4CC[C@H]3[C@@H]1CC[C@]2(C)C(=O)C1CC1)c1ccc(cc1)-c1cccnc1
Show InChI InChI=1S/C34H37NO2/c1-33(32(37)23-9-10-23)16-15-30-28-13-11-24-18-26(36)12-14-27(24)31(28)29(19-34(30,33)2)22-7-5-21(6-8-22)25-4-3-17-35-20-25/h3-8,17-18,20,23,28-30H,9-16,19H2,1-2H3/t28-,29+,30-,33+,34-/m0/s1
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n/an/a 0.130n/an/an/an/an/an/a



NV Organon

Curated by ChEMBL


Assay Description
Antagonist activity at human PRB expressed in CHO cells assessed as inhibition of Org 2058 induced-transactivation


Bioorg Med Chem 16: 2753-63 (2008)


Article DOI: 10.1016/j.bmc.2008.01.010
BindingDB Entry DOI: 10.7270/Q2Z89D9G
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50292759
PNG
(17beta-Hydroxy-11beta-[4-(5-formyl-N-methylpentyla...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)CCCCCC=O
Show InChI InChI=1S/C34H43NO3/c1-4-18-34(38)19-17-31-29-15-11-25-22-27(37)14-16-28(25)32(29)30(23-33(31,34)2)24-9-12-26(13-10-24)35(3)20-7-5-6-8-21-36/h9-10,12-13,21-22,29-31,38H,5-8,11,14-17,19-20,23H2,1-3H3/t29-,30+,31-,33-,34-/m0/s1
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n/an/a 0.150n/an/an/an/an/an/a



University of Graz

Curated by ChEMBL


Assay Description
Antagonist activity at progesterone receptor in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity after 4...


J Med Chem 52: 1268-74 (2010)


Article DOI: 10.1021/jm800985z
BindingDB Entry DOI: 10.7270/Q27S7PPM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50292778
PNG
(17beta-Hydroxy-11beta-{4-[methyl-3-(4-chlorphenyl)...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)C(=S)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C35H37ClN2O2S/c1-4-18-35(40)19-17-31-29-15-7-23-20-27(39)14-16-28(23)32(29)30(21-34(31,35)2)22-5-12-26(13-6-22)38(3)33(41)37-25-10-8-24(36)9-11-25/h5-6,8-13,20,29-31,40H,7,14-17,19,21H2,1-3H3,(H,37,41)/t29-,30+,31-,34-,35-/m0/s1
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n/an/a 0.160n/an/an/an/an/an/a



University of Graz

Curated by ChEMBL


Assay Description
Antagonist activity at progesterone receptor in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity after 4...


J Med Chem 52: 1268-74 (2010)


Article DOI: 10.1021/jm800985z
BindingDB Entry DOI: 10.7270/Q27S7PPM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50292764
PNG
(17beta-Hydroxy-11beta-[4-(2-methoxycarbonyl-N-meth...)
Show SMILES COC(=O)CCN(C)c1ccc(cc1)[C@H]1C[C@@]2(C)[C@@H](CC[C@@]2(O)C#CC)[C@@H]2CCC3=CC(=O)CCC3=C12
Show InChI InChI=1S/C32H39NO4/c1-5-16-32(36)17-14-28-26-12-8-22-19-24(34)11-13-25(22)30(26)27(20-31(28,32)2)21-6-9-23(10-7-21)33(3)18-15-29(35)37-4/h6-7,9-10,19,26-28,36H,8,11-15,17-18,20H2,1-4H3/t26-,27+,28-,31-,32-/m0/s1
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n/an/a 0.160n/an/an/an/an/an/a



University of Graz

Curated by ChEMBL


Assay Description
Antagonist activity at progesterone receptor in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity after 4...


J Med Chem 52: 1268-74 (2010)


Article DOI: 10.1021/jm800985z
BindingDB Entry DOI: 10.7270/Q27S7PPM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50292750
PNG
(17beta-Hydroxy-11beta-[4-(methylamino)-phenyl]-17a...)
Show SMILES CNc1ccc(cc1)[C@H]1C[C@@]2(C)[C@@H](CC[C@@]2(O)C#CC)[C@@H]2CCC3=CC(=O)CCC3=C12
Show InChI InChI=1S/C28H33NO2/c1-4-14-28(31)15-13-25-23-11-7-19-16-21(30)10-12-22(19)26(23)24(17-27(25,28)2)18-5-8-20(29-3)9-6-18/h5-6,8-9,16,23-25,29,31H,7,10-13,15,17H2,1-3H3/t23-,24+,25-,27-,28-/m0/s1
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n/an/a 0.170n/an/an/an/an/an/a



University of Quebec at Trois-Rivieres

Curated by ChEMBL


Assay Description
Antiprogestagenic activity at progesterone receptor in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity


Bioorg Med Chem 18: 1891-8 (2010)


Article DOI: 10.1016/j.bmc.2010.01.048
BindingDB Entry DOI: 10.7270/Q25D8SS5
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50292758
PNG
(17beta-Hydroxy-11beta-{4-[5-(1,3-dioxol-2-yl)-N-me...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)CCCCCC1OCCO1
Show InChI InChI=1S/C36H47NO4/c1-4-18-36(39)19-17-32-30-15-11-26-23-28(38)14-16-29(26)34(30)31(24-35(32,36)2)25-9-12-27(13-10-25)37(3)20-7-5-6-8-33-40-21-22-41-33/h9-10,12-13,23,30-33,39H,5-8,11,14-17,19-22,24H2,1-3H3/t30-,31+,32-,35-,36-/m0/s1
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n/an/a 0.170n/an/an/an/an/an/a



University of Graz

Curated by ChEMBL


Assay Description
Antagonist activity at progesterone receptor in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity after 4...


J Med Chem 52: 1268-74 (2010)


Article DOI: 10.1021/jm800985z
BindingDB Entry DOI: 10.7270/Q27S7PPM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50292750
PNG
(17beta-Hydroxy-11beta-[4-(methylamino)-phenyl]-17a...)
Show SMILES CNc1ccc(cc1)[C@H]1C[C@@]2(C)[C@@H](CC[C@@]2(O)C#CC)[C@@H]2CCC3=CC(=O)CCC3=C12
Show InChI InChI=1S/C28H33NO2/c1-4-14-28(31)15-13-25-23-11-7-19-16-21(30)10-12-22(19)26(23)24(17-27(25,28)2)18-5-8-20(29-3)9-6-18/h5-6,8-9,16,23-25,29,31H,7,10-13,15,17H2,1-3H3/t23-,24+,25-,27-,28-/m0/s1
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n/an/a 0.170n/an/an/an/an/an/a



University of Graz

Curated by ChEMBL


Assay Description
Antagonist activity at progesterone receptor in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity after 4...


J Med Chem 52: 1268-74 (2010)


Article DOI: 10.1021/jm800985z
BindingDB Entry DOI: 10.7270/Q27S7PPM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50292788
PNG
(17beta-Hydroxy-11beta-[4-(1-methyl-9,12-dioxo-1-az...)
Show SMILES COC(=O)CCC(=O)OCCCCCCN(C)c1ccc(cc1)[C@H]1C[C@@]2(C)[C@@H](CC[C@@]2(O)C#CC)[C@@H]2CCC3=CC(=O)CCC3=C12
Show InChI InChI=1S/C39H51NO6/c1-5-21-39(44)22-20-34-32-16-12-28-25-30(41)15-17-31(28)37(32)33(26-38(34,39)2)27-10-13-29(14-11-27)40(3)23-8-6-7-9-24-46-36(43)19-18-35(42)45-4/h10-11,13-14,25,32-34,44H,6-9,12,15-20,22-24,26H2,1-4H3/t32-,33+,34-,38-,39-/m0/s1
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n/an/a 0.170n/an/an/an/an/an/a



University of Graz

Curated by ChEMBL


Assay Description
Antagonist activity at progesterone receptor in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity after 4...


J Med Chem 52: 1268-74 (2010)


Article DOI: 10.1021/jm800985z
BindingDB Entry DOI: 10.7270/Q27S7PPM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM18627
PNG
((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
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n/an/a 0.180n/an/an/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Concentration required to give half-maximal inhibition against human Progesterone receptor B isoform in co-transfected CV-1 cell lines.


J Med Chem 39: 1778-89 (1996)


Article DOI: 10.1021/jm950747d
BindingDB Entry DOI: 10.7270/Q2416XQ2
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Progesterone receptor


(Homo sapiens (Human))
BDBM50292754
PNG
(17beta-Hydroxy-11beta-[4-(N-methylhexylamino)-phen...)
Show SMILES CCCCCCN(C)c1ccc(cc1)[C@H]1C[C@@]2(C)[C@@H](CC[C@@]2(O)C#CC)[C@@H]2CCC3=CC(=O)CCC3=C12
Show InChI InChI=1S/C34H45NO2/c1-5-7-8-9-21-35(4)26-13-10-24(11-14-26)30-23-33(3)31(18-20-34(33,37)19-6-2)29-16-12-25-22-27(36)15-17-28(25)32(29)30/h10-11,13-14,22,29-31,37H,5,7-9,12,15-18,20-21,23H2,1-4H3/t29-,30+,31-,33-,34-/m0/s1
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n/an/a 0.180n/an/an/an/an/an/a



University of Graz

Curated by ChEMBL


Assay Description
Antagonist activity at progesterone receptor in human T47D-C124 cells transfected with luciferase gene linked to MMTV promoter assessed as inhibition...


J Med Chem 52: 1268-74 (2010)


Article DOI: 10.1021/jm800985z
BindingDB Entry DOI: 10.7270/Q27S7PPM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM18627
PNG
((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
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n/an/a 0.180n/an/an/an/an/an/a



Ligand Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Antagonistic activity against human progesterone receptor B (hPR-B) in co-transfected CV-1 cells.


J Med Chem 41: 623-39 (1998)


Article DOI: 10.1021/jm970699s
BindingDB Entry DOI: 10.7270/Q2VM4CZ6
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Progesterone receptor


(Homo sapiens (Human))
BDBM50375444
PNG
(CHEMBL258861)
Show SMILES CN(C)c1ccc(cc1)[C@H]1C[C@@]2(C)[C@@H](CC[C@]22OCCC2=C)[C@@H]2CCC3=CC(=O)CCC3[C@@H]12
Show InChI InChI=1S/C30H39NO2/c1-19-14-16-33-30(19)15-13-27-25-11-7-21-17-23(32)10-12-24(21)28(25)26(18-29(27,30)2)20-5-8-22(9-6-20)31(3)4/h5-6,8-9,17,24-28H,1,7,10-16,18H2,2-4H3/t24?,25-,26+,27-,28+,29-,30+/m0/s1
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NV Organon

Curated by ChEMBL


Assay Description
Antagonist activity at human PRB expressed in CHO cells assessed as inhibition of Org 2058 induced-transactivation relative to Org 31710


Bioorg Med Chem 16: 2753-63 (2008)


Article DOI: 10.1016/j.bmc.2008.01.010
BindingDB Entry DOI: 10.7270/Q2Z89D9G
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50375445
PNG
(CHEMBL445946)
Show SMILES CN(C)c1ccc(cc1)[C@H]1C[C@@]2(C)[C@@H](CC[C@@]22CCCC2=O)[C@@H]2CCC3=CC(=O)CCC3=C12
Show InChI InChI=1S/C30H37NO2/c1-29-18-25(19-6-9-21(10-7-19)31(2)3)28-23-13-11-22(32)17-20(23)8-12-24(28)26(29)14-16-30(29)15-4-5-27(30)33/h6-7,9-10,17,24-26H,4-5,8,11-16,18H2,1-3H3/t24-,25+,26-,29-,30+/m0/s1
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NV Organon

Curated by ChEMBL


Assay Description
Antagonist activity at human PRB expressed in CHO cells assessed as inhibition of Org 2058 induced-transactivation relative to Org 31710


Bioorg Med Chem 16: 2753-63 (2008)


Article DOI: 10.1016/j.bmc.2008.01.010
BindingDB Entry DOI: 10.7270/Q2Z89D9G
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM18627
PNG
((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
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n/an/a 0.200n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Antagonistic activity against Progesterone receptor (PR) in transcriptional activation assay in human T47D breast carcinoma cell line


Bioorg Med Chem Lett 12: 787-90 (2002)


Article DOI: 10.1016/s0960-894x(02)00025-2
BindingDB Entry DOI: 10.7270/Q2WS8TSW
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Progesterone receptor


(Homo sapiens (Human))
BDBM18627
PNG
((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
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Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at progesterone receptor in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity


Bioorg Med Chem Lett 20: 4816-8 (2010)


Article DOI: 10.1016/j.bmcl.2010.06.109
BindingDB Entry DOI: 10.7270/Q2ZW1MX6
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Progesterone receptor


(Homo sapiens (Human))
BDBM18627
PNG
((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
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n/an/a 0.200n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at human PR expressed in human T47D cells assessed as inhibition of progesterone induced alkaline phosphatase


J Med Chem 51: 1861-73 (2008)


Article DOI: 10.1021/jm701080t
BindingDB Entry DOI: 10.7270/Q2G44R56
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Progesterone receptor


(Homo sapiens (Human))
BDBM18627
PNG
((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of progesterone receptor mediated progesterone-induced alkaline phosphatase activity in human T47D cells


Bioorg Med Chem 16: 6589-600 (2008)


Article DOI: 10.1016/j.bmc.2008.05.018
BindingDB Entry DOI: 10.7270/Q2V125QZ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Progesterone receptor


(Homo sapiens (Human))
BDBM50375424
PNG
(ULIPRISTAL ACETATE | Ulipristal)
Show SMILES CN(C)c1ccc(cc1)[C@H]1C[C@@]2(C)[C@@H](CC[C@]2(OC(C)=O)C(C)=O)[C@@H]2CCC3=CC(=O)CCC3=C12
Show InChI InChI=1S/C30H37NO4/c1-18(32)30(35-19(2)33)15-14-27-25-12-8-21-16-23(34)11-13-24(21)28(25)26(17-29(27,30)3)20-6-9-22(10-7-20)31(4)5/h6-7,9-10,16,25-27H,8,11-15,17H2,1-5H3/t25-,26+,27-,29-,30-/m0/s1
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NV Organon

Curated by ChEMBL


Assay Description
Antagonist activity at human PRB expressed in CHO cells assessed as inhibition of Org 2058 induced-transactivation


Bioorg Med Chem 16: 2753-63 (2008)


Article DOI: 10.1016/j.bmc.2008.01.010
BindingDB Entry DOI: 10.7270/Q2Z89D9G
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Progesterone receptor


(Homo sapiens (Human))
BDBM18627
PNG
((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
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Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Inhibitory concentration against progesterone stimulated alkaline phosphatase activity in T47D human breast carcinoma cell line


Bioorg Med Chem Lett 11: 2747-50 (2001)


Article DOI: 10.1016/s0960-894x(01)00554-6
BindingDB Entry DOI: 10.7270/Q2222V92
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Progesterone receptor


(Homo sapiens (Human))
BDBM50081070
PNG
(CHEMBL3421892)
Show SMILES Cc1noc(=O)c2ccc(NC(=O)C(O)(CC3(CCC3)c3cc(F)ccc3Cl)C(F)(F)F)cc12
Show InChI InChI=1S/C23H19ClF4N2O4/c1-12-16-10-14(4-5-15(16)19(31)34-30-12)29-20(32)22(33,23(26,27)28)11-21(7-2-8-21)17-9-13(25)3-6-18(17)24/h3-6,9-10,33H,2,7-8,11H2,1H3,(H,29,32)
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TBA

Curated by ChEMBL


Assay Description
Binding affinity to human PR


J Med Chem 58: 2658-77 (2015)


Article DOI: 10.1021/jm501601b
BindingDB Entry DOI: 10.7270/Q2GM891C
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM18627
PNG
((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
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Wyeth Research

Curated by ChEMBL


Assay Description
Antagonist activity at progesterone receptor assessed as progesterone-induced alkaline phosphatase activity in human T47D cells


Bioorg Med Chem Lett 18: 5015-7 (2008)


Article DOI: 10.1016/j.bmcl.2008.08.015
BindingDB Entry DOI: 10.7270/Q25B03D7
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Progesterone receptor


(Homo sapiens (Human))
BDBM8903
PNG
((1S,2R,10S,11S,14S,15S)-14-acetyl-2,15-dimethyltet...)
Show SMILES CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C
Show InChI InChI=1S/C21H30O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19H,4-11H2,1-3H3/t16-,17+,18-,19-,20-,21+/m0/s1
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TBA

Curated by ChEMBL


Assay Description
Binding affinity to progesterone receptor


ACS Med Chem Lett 2: 124-129 (2011)


Article DOI: 10.1021/ml1002508
BindingDB Entry DOI: 10.7270/Q2JQ119N
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Progesterone receptor


(Homo sapiens (Human))
BDBM50375423
PNG
(ASOPRISNIL)
Show SMILES COC[C@@]1(CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(CN=O)cc1)OC
Show InChI InChI=1S/C28H35NO4/c1-27-15-24(19-6-4-18(5-7-19)16-29-31)26-22-11-9-21(30)14-20(22)8-10-23(26)25(27)12-13-28(27,33-3)17-32-2/h4-7,14,23-25H,8-13,15-17H2,1-3H3/t23-,24+,25-,27-,28+/m0/s1
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NV Organon

Curated by ChEMBL


Assay Description
Antagonist activity at human PRB expressed in CHO cells assessed as inhibition of Org 2058 induced-transactivation


Bioorg Med Chem 16: 2753-63 (2008)


Article DOI: 10.1016/j.bmc.2008.01.010
BindingDB Entry DOI: 10.7270/Q2Z89D9G
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50169743
PNG
((13S,17S)-13-Methyl-7-[9-(4,4,5,5,5-pentafluoro-pe...)
Show SMILES C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)[C@H](CCCCCCCCCS(=O)CCCC(F)(F)C(F)(F)F)Cc1cc(O)ccc31
Show InChI InChI=1S/C32H47F5O3S/c1-30-17-15-26-25-12-11-24(38)21-23(25)20-22(29(26)27(30)13-14-28(30)39)10-7-5-3-2-4-6-8-18-41(40)19-9-16-31(33,34)32(35,36)37/h11-12,21-22,26-29,38-39H,2-10,13-20H2,1H3/t22-,26-,27+,28+,29-,30+,41?/m1/s1
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n/an/a 0.209n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Antagonist activity at progesterone receptor in human MCF cells assessed as estradiol-induced receptor response


J Med Chem 58: 8128-40 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00984
BindingDB Entry DOI: 10.7270/Q2F76FCN
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50292786
PNG
(17beta-Hydroxy-11beta-[4-(12-hydroxy-1-methyl-9,12...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)CCCCCCOC(=O)CCC(O)=O
Show InChI InChI=1S/C38H49NO6/c1-4-20-38(44)21-19-33-31-15-11-27-24-29(40)14-16-30(27)36(31)32(25-37(33,38)2)26-9-12-28(13-10-26)39(3)22-7-5-6-8-23-45-35(43)18-17-34(41)42/h9-10,12-13,24,31-33,44H,5-8,11,14-19,21-23,25H2,1-3H3,(H,41,42)/t31-,32+,33-,37-,38-/m0/s1
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University of Graz

Curated by ChEMBL


Assay Description
Antagonist activity at progesterone receptor in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity after 4...


J Med Chem 52: 1268-74 (2010)


Article DOI: 10.1021/jm800985z
BindingDB Entry DOI: 10.7270/Q27S7PPM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM18627
PNG
((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1
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GlaxoSmithKline

Curated by ChEMBL


Assay Description
Antagonist activity against PR beta-mediated transactivation of MMTV luciferase reporter gene in BacMam transduced progesterone-stimulated CV1 cells


Bioorg Med Chem Lett 16: 3777-9 (2006)


Article DOI: 10.1016/j.bmcl.2006.04.055
BindingDB Entry DOI: 10.7270/Q2HM59RZ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Progesterone receptor


(Homo sapiens (Human))
BDBM50375438
PNG
(CHEMBL410923)
Show SMILES C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]2(C)[C@H]1C(=O)C1CC1)c1ccc(cc1)-c1cccnc1
Show InChI InChI=1S/C34H37NO2/c1-20-16-30-28-13-11-24-17-26(36)12-14-27(24)31(28)29(18-34(30,2)32(20)33(37)23-9-10-23)22-7-5-21(6-8-22)25-4-3-15-35-19-25/h3-8,15,17,19-20,23,28-30,32H,9-14,16,18H2,1-2H3/t20-,28+,29-,30+,32-,34+/m1/s1
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NV Organon

Curated by ChEMBL


Assay Description
Antagonist activity at human PRB expressed in CHO cells assessed as inhibition of Org 2058 induced-transactivation


Bioorg Med Chem 16: 2753-63 (2008)


Article DOI: 10.1016/j.bmc.2008.01.010
BindingDB Entry DOI: 10.7270/Q2Z89D9G
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50206106
PNG
((8S,11R,13S,14R)-11-(4-dimethylamino-phenyl)-17-(4...)
Show SMILES CN(C)c1ccc(cc1)[C@H]1C[C@@]2(C)[C@@H](CC[C@@]2(O)C#Cc2ccc(F)cc2)[C@@H]2OCC3=CC(=O)CCC3=C12
Show InChI InChI=1S/C33H34FNO3/c1-32-19-28(22-6-10-25(11-7-22)35(2)3)30-27-13-12-26(36)18-23(27)20-38-31(30)29(32)15-17-33(32,37)16-14-21-4-8-24(34)9-5-21/h4-11,18,28-29,31,37H,12-13,15,17,19-20H2,1-3H3/t28-,29+,31+,32+,33+/m1/s1
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Johnson and Johnson Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human progesterone receptor assessed as inhibition of alkaline phosphatase activity in human T47D cells


Bioorg Med Chem Lett 17: 2531-4 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.013
BindingDB Entry DOI: 10.7270/Q2RV0PH2
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50292777
PNG
(17beta-Hydroxy-11beta-{4-[methyl-3-(4-chlorphenyl)...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)C(=O)Nc1ccc(Cl)cc1
Show InChI InChI=1S/C35H37ClN2O3/c1-4-18-35(41)19-17-31-29-15-7-23-20-27(39)14-16-28(23)32(29)30(21-34(31,35)2)22-5-12-26(13-6-22)38(3)33(40)37-25-10-8-24(36)9-11-25/h5-6,8-13,20,29-31,41H,7,14-17,19,21H2,1-3H3,(H,37,40)/t29-,30+,31-,34-,35-/m0/s1
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University of Graz

Curated by ChEMBL


Assay Description
Antagonist activity at progesterone receptor in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity after 4...


J Med Chem 52: 1268-74 (2010)


Article DOI: 10.1021/jm800985z
BindingDB Entry DOI: 10.7270/Q27S7PPM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50292762
PNG
(17beta-Hydroxy-11beta-[4-(7-carboxy-N-methylheptyl...)
Show SMILES CC#C[C@]1(O)CC[C@H]2[C@@H]3CCC4=CC(=O)CCC4=C3[C@H](C[C@]12C)c1ccc(cc1)N(C)CCCCCCCC(O)=O
Show InChI InChI=1S/C36H47NO4/c1-4-20-36(41)21-19-32-30-17-13-26-23-28(38)16-18-29(26)34(30)31(24-35(32,36)2)25-11-14-27(15-12-25)37(3)22-9-7-5-6-8-10-33(39)40/h11-12,14-15,23,30-32,41H,5-10,13,16-19,21-22,24H2,1-3H3,(H,39,40)/t30-,31+,32-,35-,36-/m0/s1
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University of Graz

Curated by ChEMBL


Assay Description
Antagonist activity at progesterone receptor in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity after 4...


J Med Chem 52: 1268-74 (2010)


Article DOI: 10.1021/jm800985z
BindingDB Entry DOI: 10.7270/Q27S7PPM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50292753
PNG
(17beta-Hydroxy-11beta-[4-(N-methylpropylamino)-phe...)
Show SMILES CCCN(C)c1ccc(cc1)[C@H]1C[C@@]2(C)[C@@H](CC[C@@]2(O)C#CC)[C@@H]2CCC3=CC(=O)CCC3=C12
Show InChI InChI=1S/C31H39NO2/c1-5-16-31(34)17-15-28-26-13-9-22-19-24(33)12-14-25(22)29(26)27(20-30(28,31)3)21-7-10-23(11-8-21)32(4)18-6-2/h7-8,10-11,19,26-28,34H,6,9,12-15,17-18,20H2,1-4H3/t26-,27+,28-,30-,31-/m0/s1
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University of Graz

Curated by ChEMBL


Assay Description
Antagonist activity at progesterone receptor in human T47D cells assessed as inhibition of progesterone-induced alkaline phosphatase activity after 4...


J Med Chem 52: 1268-74 (2010)


Article DOI: 10.1021/jm800985z
BindingDB Entry DOI: 10.7270/Q27S7PPM
More data for this
Ligand-Target Pair
Progesterone receptor


(Homo sapiens (Human))
BDBM50125052
PNG
(CHEMBL3623004)
Show SMILES C[C@@H]1Cc2c([nH]c3ccccc23)[C@H](N1CC(C)(C)F)c1c(F)cc(\C=C\C(O)=O)cc1F
Show InChI InChI=1S/C25H25F3N2O2/c1-14-10-17-16-6-4-5-7-20(16)29-23(17)24(30(14)13-25(2,3)28)22-18(26)11-15(12-19(22)27)8-9-21(31)32/h4-9,11-12,14,24,29H,10,13H2,1-3H3,(H,31,32)/b9-8+/t14-,24-/m1/s1
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n/an/a 0.282n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Antagonist activity at progesterone receptor in human MCF cells assessed as estradiol-induced receptor response


J Med Chem 58: 8128-40 (2015)


Article DOI: 10.1021/acs.jmedchem.5b00984
BindingDB Entry DOI: 10.7270/Q2F76FCN
More data for this
Ligand-Target Pair
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