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Compile Data Set for Download or QSAR

Found 93 hits of ec50 for UniProtKB: A0A024R9X6   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM50001728
PNG
(8-Chloro-1-methyl-6-phenyl-4H-s-triazolo(4,3-a)(1,...)
Show SMILES Cc1nnc2CN=C(c3ccccc3)c3cc(Cl)ccc3-n12
Show InChI InChI=1S/C17H13ClN4/c1-11-20-21-16-10-19-17(12-5-3-2-4-6-12)14-9-13(18)7-8-15(14)22(11)16/h2-9H,10H2,1H3
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n/an/an/an/a 12n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2


J Med Chem 45: 5043-51 (2002)


Article DOI: 10.1021/jm0202019
BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-3/gamma-2 subunit


(Homo sapiens (Human))
BDBM50065229
PNG
(4-Ethyl-6,7-dimethoxy-9H-beta-carboline-3-carboxyl...)
Show SMILES CCc1c([nH]cc2nc3cc(OC)c(OC)cc3c12)C(=O)OC
Show InChI InChI=1S/C17H18N2O4/c1-5-9-15-10-6-13(21-2)14(22-3)7-11(10)19-12(15)8-18-16(9)17(20)23-4/h6-8,18H,5H2,1-4H3
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n/an/an/an/a 14n/an/an/an/a



AstraZeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity to human alpha2beta3gamma2 GABA receptor expressed in Xenopus laevis oocytes


Bioorg Med Chem 18: 8374-82 (2010)


Article DOI: 10.1016/j.bmc.2010.09.058
BindingDB Entry DOI: 10.7270/Q2FB536X
More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM50120783
PNG
(8-Benzyl-2-(2-fluoro-phenyl)-6,7,8,9-tetrahydro-5H...)
Show SMILES Fc1ccccc1-c1cn2c(n1)c1CN(Cc3ccccc3)CCc1[nH]c2=O
Show InChI InChI=1S/C22H19FN4O/c23-18-9-5-4-8-16(18)20-14-27-21(24-20)17-13-26(11-10-19(17)25-22(27)28)12-15-6-2-1-3-7-15/h1-9,14H,10-13H2,(H,25,28)
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n/an/an/an/a 20n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2


J Med Chem 45: 5043-51 (2002)


Article DOI: 10.1021/jm0202019
BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-3/gamma-2 subunit


(Homo sapiens (Human))
BDBM50332374
PNG
(9-Amino-2-cyclobutyl-5-(pyrimidin-2-yl)-2,3-dihydr...)
Show SMILES Nc1c2c(cn(C3CCC3)c2=O)[nH]c2c(cccc12)-c1ncccn1
Show InChI InChI=1S/C19H17N5O/c20-16-12-6-2-7-13(18-21-8-3-9-22-18)17(12)23-14-10-24(11-4-1-5-11)19(25)15(14)16/h2-3,6-11,23H,1,4-5,20H2
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n/an/an/an/a 34n/an/an/an/a



AstraZeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity to human alpha2beta3gamma2 GABA receptor expressed in Xenopus laevis oocytes


Bioorg Med Chem 18: 8374-82 (2010)


Article DOI: 10.1016/j.bmc.2010.09.058
BindingDB Entry DOI: 10.7270/Q2FB536X
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-3/gamma-2 subunit


(Homo sapiens (Human))
BDBM50000766
PNG
(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)
Show SMILES CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccccc1
Show InChI InChI=1S/C16H13ClN2O/c1-19-14-8-7-12(17)9-13(14)16(18-10-15(19)20)11-5-3-2-4-6-11/h2-9H,10H2,1H3
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n/an/an/an/a 35n/an/an/an/a



AstraZeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity to human alpha2beta3gamma2 GABA receptor expressed in Xenopus laevis oocytes


Bioorg Med Chem 18: 8374-82 (2010)


Article DOI: 10.1016/j.bmc.2010.09.058
BindingDB Entry DOI: 10.7270/Q2FB536X
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
GABA receptor alpha-2/beta-3/gamma-2 subunit


(Homo sapiens (Human))
BDBM50332375
PNG
(4-Amino-8-(5-(azetidine-1-carbonyl)pyridin-3-yl)-N...)
Show SMILES CCCNC(=O)c1nnc2c(cccc2c1N)-c1cncc(c1)C(=O)N1CCC1
Show InChI InChI=1S/C21H22N6O2/c1-2-7-24-20(28)19-17(22)16-6-3-5-15(18(16)25-26-19)13-10-14(12-23-11-13)21(29)27-8-4-9-27/h3,5-6,10-12H,2,4,7-9H2,1H3,(H2,22,25)(H,24,28)
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n/an/an/an/a 54n/an/an/an/a



AstraZeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity to human alpha2beta3gamma2 GABA receptor expressed in Xenopus laevis oocytes


Bioorg Med Chem 18: 8374-82 (2010)


Article DOI: 10.1016/j.bmc.2010.09.058
BindingDB Entry DOI: 10.7270/Q2FB536X
More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM50120779
PNG
(8-(4-Fluoro-benzoyl)-2-(2-fluoro-phenyl)-6,7,8,9-t...)
Show SMILES Fc1ccc(cc1)C(=O)N1CCc2[nH]c(=O)n3cc(nc3c2C1)-c1ccccc1F
Show InChI InChI=1S/C22H16F2N4O2/c23-14-7-5-13(6-8-14)21(29)27-10-9-18-16(11-27)20-25-19(12-28(20)22(30)26-18)15-3-1-2-4-17(15)24/h1-8,12H,9-11H2,(H,26,30)
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n/an/an/an/a 55n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2


J Med Chem 45: 5043-51 (2002)


Article DOI: 10.1021/jm0202019
BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM50120794
PNG
(2-(2-Fluoro-phenyl)-8-thiophen-2-ylmethyl-6,7,8,9-...)
Show SMILES Fc1ccccc1-c1cn2c(n1)c1CN(Cc3cccs3)CCc1[nH]c2=O
Show InChI InChI=1S/C20H17FN4OS/c21-16-6-2-1-5-14(16)18-12-25-19(22-18)15-11-24(10-13-4-3-9-27-13)8-7-17(15)23-20(25)26/h1-6,9,12H,7-8,10-11H2,(H,23,26)
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n/an/an/an/a 67n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2


J Med Chem 45: 5043-51 (2002)


Article DOI: 10.1021/jm0202019
BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM50120777
PNG
(8-(3-Fluoro-benzoyl)-2-(2-fluoro-phenyl)-6,7,8,9-t...)
Show SMILES Fc1cccc(c1)C(=O)N1CCc2[nH]c(=O)n3cc(nc3c2C1)-c1ccccc1F
Show InChI InChI=1S/C22H16F2N4O2/c23-14-5-3-4-13(10-14)21(29)27-9-8-18-16(11-27)20-25-19(12-28(20)22(30)26-18)15-6-1-2-7-17(15)24/h1-7,10,12H,8-9,11H2,(H,26,30)
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n/an/an/an/a 70n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2


J Med Chem 45: 5043-51 (2002)


Article DOI: 10.1021/jm0202019
BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM50120801
PNG
(2-(2-Fluoro-phenyl)-8-pyrimidin-2-yl-6,7,8,9-tetra...)
Show SMILES Fc1ccccc1-c1cn2c(n1)c1CN(CCc1[nH]c2=O)c1ncccn1
Show InChI InChI=1S/C19H15FN6O/c20-14-5-2-1-4-12(14)16-11-26-17(23-16)13-10-25(18-21-7-3-8-22-18)9-6-15(13)24-19(26)27/h1-5,7-8,11H,6,9-10H2,(H,24,27)
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n/an/an/an/a 84n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2


J Med Chem 45: 5043-51 (2002)


Article DOI: 10.1021/jm0202019
BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM50120775
PNG
(2-(2-Fluoro-phenyl)-8-pyridin-4-ylmethyl-6,7,8,9-t...)
Show SMILES Fc1ccccc1-c1cn2c(n1)c1CN(Cc3ccncc3)CCc1[nH]c2=O
Show InChI InChI=1S/C21H18FN5O/c22-17-4-2-1-3-15(17)19-13-27-20(24-19)16-12-26(10-7-18(16)25-21(27)28)11-14-5-8-23-9-6-14/h1-6,8-9,13H,7,10-12H2,(H,25,28)
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n/an/an/an/a 99n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2


J Med Chem 45: 5043-51 (2002)


Article DOI: 10.1021/jm0202019
BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM50120782
PNG
(2-(2-Fluoro-phenyl)-8-pyridin-3-ylmethyl-6,7,8,9-t...)
Show SMILES Fc1ccccc1-c1cn2c(n1)c1CN(Cc3cccnc3)CCc1[nH]c2=O
Show InChI InChI=1S/C21H18FN5O/c22-17-6-2-1-5-15(17)19-13-27-20(24-19)16-12-26(9-7-18(16)25-21(27)28)11-14-4-3-8-23-10-14/h1-6,8,10,13H,7,9,11-12H2,(H,25,28)
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n/an/an/an/a 101n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2


J Med Chem 45: 5043-51 (2002)


Article DOI: 10.1021/jm0202019
BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-3/gamma-2 subunit


(Homo sapiens (Human))
BDBM50332376
PNG
(4-Amino-N-propyl-8-(pyrimidin-2-yl)cinnoline-3-car...)
Show SMILES CCCNC(=O)c1nnc2c(cccc2c1N)-c1ncccn1
Show InChI InChI=1S/C16H16N6O/c1-2-7-20-16(23)14-12(17)10-5-3-6-11(13(10)21-22-14)15-18-8-4-9-19-15/h3-6,8-9H,2,7H2,1H3,(H2,17,21)(H,20,23)
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n/an/an/an/a 104n/an/an/an/a



AstraZeneca Pharmaceuticals

Curated by ChEMBL


Assay Description
Binding affinity to human alpha2beta3gamma2 GABA receptor expressed in Xenopus laevis oocytes


Bioorg Med Chem 18: 8374-82 (2010)


Article DOI: 10.1016/j.bmc.2010.09.058
BindingDB Entry DOI: 10.7270/Q2FB536X
More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM50120772
PNG
(2-(2-Fluoro-phenyl)-8-propionyl-6,7,8,9-tetrahydro...)
Show SMILES CCC(=O)N1CCc2[nH]c(=O)n3cc(nc3c2C1)-c1ccccc1F
Show InChI InChI=1S/C18H17FN4O2/c1-2-16(24)22-8-7-14-12(9-22)17-20-15(10-23(17)18(25)21-14)11-5-3-4-6-13(11)19/h3-6,10H,2,7-9H2,1H3,(H,21,25)
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n/an/an/an/a 110n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2


J Med Chem 45: 5043-51 (2002)


Article DOI: 10.1021/jm0202019
BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-3/gamma-2 subunit


(Homo sapiens (Human))
BDBM50259814
PNG
(CHEMBL4062225)
Show SMILES C#Cc1ccc-2c(c1)C(=NCc1c(ncn-21)-c1cnco1)c1ccccn1
Show InChI InChI=1S/C21H13N5O/c1-2-14-6-7-17-15(9-14)20(16-5-3-4-8-23-16)24-10-18-21(25-12-26(17)18)19-11-22-13-27-19/h1,3-9,11-13H,10H2
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n/an/an/an/a 118n/an/an/an/a



University of Wisconsin-Milwaukee

Curated by ChEMBL


Assay Description
Binding affinity to human GABAA alpha1beta3gamma2 receptor expressed in HEK293 cells assessed as GABA-induced membrane potential change preincubated ...


J Med Chem 59: 10800-10806 (2016)


Article DOI: 10.1021/acs.jmedchem.6b01332
BindingDB Entry DOI: 10.7270/Q2SQ92T0
More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM50120795
PNG
(2-(2-Fluoro-phenyl)-8-(2-methyl-benzoyl)-6,7,8,9-t...)
Show SMILES Cc1ccccc1C(=O)N1CCc2[nH]c(=O)n3cc(nc3c2C1)-c1ccccc1F
Show InChI InChI=1S/C23H19FN4O2/c1-14-6-2-3-7-15(14)22(29)27-11-10-19-17(12-27)21-25-20(13-28(21)23(30)26-19)16-8-4-5-9-18(16)24/h2-9,13H,10-12H2,1H3,(H,26,30)
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n/an/an/an/a 134n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2


J Med Chem 45: 5043-51 (2002)


Article DOI: 10.1021/jm0202019
BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM50120812
PNG
(8-Benzyl-2-(4-methoxy-phenyl)-6,7,8,9-tetrahydro-5...)
Show SMILES COc1ccc(cc1)-c1cn2c(n1)c1CN(Cc3ccccc3)CCc1[nH]c2=O
Show InChI InChI=1S/C23H22N4O2/c1-29-18-9-7-17(8-10-18)21-15-27-22(24-21)19-14-26(12-11-20(19)25-23(27)28)13-16-5-3-2-4-6-16/h2-10,15H,11-14H2,1H3,(H,25,28)
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n/an/an/an/a 143n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2


J Med Chem 45: 5043-51 (2002)


Article DOI: 10.1021/jm0202019
BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM50120781
PNG
(8-Benzyl-2-(3-fluoro-phenyl)-6,7,8,9-tetrahydro-5H...)
Show SMILES Fc1cccc(c1)-c1cn2c(n1)c1CN(Cc3ccccc3)CCc1[nH]c2=O
Show InChI InChI=1S/C22H19FN4O/c23-17-8-4-7-16(11-17)20-14-27-21(24-20)18-13-26(10-9-19(18)25-22(27)28)12-15-5-2-1-3-6-15/h1-8,11,14H,9-10,12-13H2,(H,25,28)
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n/an/an/an/a 154n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2


J Med Chem 45: 5043-51 (2002)


Article DOI: 10.1021/jm0202019
BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM50120809
PNG
(8-Benzyl-2-phenyl-6,7,8,9-tetrahydro-5H-1,3a,5,8-t...)
Show SMILES O=c1[nH]c2CCN(Cc3ccccc3)Cc2c2nc(cn12)-c1ccccc1
Show InChI InChI=1S/C22H20N4O/c27-22-24-19-11-12-25(13-16-7-3-1-4-8-16)14-18(19)21-23-20(15-26(21)22)17-9-5-2-6-10-17/h1-10,15H,11-14H2,(H,24,27)
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n/an/an/an/a 184n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2


J Med Chem 45: 5043-51 (2002)


Article DOI: 10.1021/jm0202019
BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM50120790
PNG
(8-Benzyl-2-(2,5-difluoro-phenyl)-6,7,8,9-tetrahydr...)
Show SMILES Fc1ccc(F)c(c1)-c1cn2c(n1)c1CN(Cc3ccccc3)CCc1[nH]c2=O
Show InChI InChI=1S/C22H18F2N4O/c23-15-6-7-18(24)16(10-15)20-13-28-21(25-20)17-12-27(9-8-19(17)26-22(28)29)11-14-4-2-1-3-5-14/h1-7,10,13H,8-9,11-12H2,(H,26,29)
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n/an/an/an/a 188n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2


J Med Chem 45: 5043-51 (2002)


Article DOI: 10.1021/jm0202019
BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens (Human))
BDBM50164567
PNG
(2-(4-Bromo-phenyl)-1-(2,4-dichloro-phenyl)-1H-imid...)
Show SMILES CCOC(=O)c1cn(c(n1)-c1ccc(Br)cc1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C18H13BrCl2N2O2/c1-2-25-18(24)15-10-23(16-8-7-13(20)9-14(16)21)17(22-15)11-3-5-12(19)6-4-11/h3-10H,2H2,1H3
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n/an/an/an/a 190n/an/an/an/a



Universit£ di Sassari

Curated by ChEMBL


Assay Description
Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...


J Med Chem 48: 2638-45 (2005)


Article DOI: 10.1021/jm049120y
BindingDB Entry DOI: 10.7270/Q2VH5PMS
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-3/gamma-2 subunit


(Homo sapiens (Human))
BDBM50373060
PNG
(CHEMBL257155)
Show SMILES CCOC(=O)C(C=Nc1ccc(OCC)cc1)C(=O)c1ccccc1Cl
Show InChI InChI=1S/C20H20ClNO4/c1-3-25-15-11-9-14(10-12-15)22-13-17(20(24)26-4-2)19(23)16-7-5-6-8-18(16)21/h5-13,17H,3-4H2,1-2H3
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n/an/an/an/a 200n/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Activation of human GABAA alpha-2-beta-3-gamma-2L receptor expressed in Xenopus oocytes assessed as modulation of nicotine-induced current by two-ele...


Proc Natl Acad Sci U S A 104: 8059-64 (2007)


Article DOI: 10.1073/pnas.0701321104
BindingDB Entry DOI: 10.7270/Q2NS0VS3
More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM50120791
PNG
(8-Cyclohexylmethyl-2-(2-fluoro-phenyl)-6,7,8,9-tet...)
Show SMILES Fc1ccccc1-c1cn2c(n1)c1CN(CC3CCCCC3)CCc1[nH]c2=O
Show InChI InChI=1S/C22H25FN4O/c23-18-9-5-4-8-16(18)20-14-27-21(24-20)17-13-26(11-10-19(17)25-22(27)28)12-15-6-2-1-3-7-15/h4-5,8-9,14-15H,1-3,6-7,10-13H2,(H,25,28)
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n/an/an/an/a 202n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2


J Med Chem 45: 5043-51 (2002)


Article DOI: 10.1021/jm0202019
BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM50120776
PNG
(8-Benzyl-2-(2,4-difluoro-phenyl)-6,7,8,9-tetrahydr...)
Show SMILES Fc1ccc(-c2cn3c(n2)c2CN(Cc4ccccc4)CCc2[nH]c3=O)c(F)c1
Show InChI InChI=1S/C22H18F2N4O/c23-15-6-7-16(18(24)10-15)20-13-28-21(25-20)17-12-27(9-8-19(17)26-22(28)29)11-14-4-2-1-3-5-14/h1-7,10,13H,8-9,11-12H2,(H,26,29)
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n/an/an/an/a 210n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2


J Med Chem 45: 5043-51 (2002)


Article DOI: 10.1021/jm0202019
BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM50120799
PNG
(8-(3,4-Difluoro-benzoyl)-2-(2-fluoro-phenyl)-6,7,8...)
Show SMILES Fc1ccc(cc1F)C(=O)N1CCc2[nH]c(=O)n3cc(nc3c2C1)-c1ccccc1F
Show InChI InChI=1S/C22H15F3N4O2/c23-15-4-2-1-3-13(15)19-11-29-20(26-19)14-10-28(8-7-18(14)27-22(29)31)21(30)12-5-6-16(24)17(25)9-12/h1-6,9,11H,7-8,10H2,(H,27,31)
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n/an/an/an/a 238n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2


J Med Chem 45: 5043-51 (2002)


Article DOI: 10.1021/jm0202019
BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM50120789
PNG
(8-Benzyl-2-(4-fluoro-phenyl)-6,7,8,9-tetrahydro-5H...)
Show SMILES Fc1ccc(cc1)-c1cn2c(n1)c1CN(Cc3ccccc3)CCc1[nH]c2=O
Show InChI InChI=1S/C22H19FN4O/c23-17-8-6-16(7-9-17)20-14-27-21(24-20)18-13-26(11-10-19(18)25-22(27)28)12-15-4-2-1-3-5-15/h1-9,14H,10-13H2,(H,25,28)
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n/an/an/an/a 245n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2


J Med Chem 45: 5043-51 (2002)


Article DOI: 10.1021/jm0202019
BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM50120788
PNG
(8-Butyl-2-(2-fluoro-phenyl)-6,7,8,9-tetrahydro-5H-...)
Show SMILES CCCCN1CCc2[nH]c(=O)n3cc(nc3c2C1)-c1ccccc1F
Show InChI InChI=1S/C19H21FN4O/c1-2-3-9-23-10-8-16-14(11-23)18-21-17(12-24(18)19(25)22-16)13-6-4-5-7-15(13)20/h4-7,12H,2-3,8-11H2,1H3,(H,22,25)
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n/an/an/an/a 247n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2


J Med Chem 45: 5043-51 (2002)


Article DOI: 10.1021/jm0202019
BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM50120773
PNG
(8-(2-Fluoro-benzoyl)-2-(2-fluoro-phenyl)-6,7,8,9-t...)
Show SMILES Fc1ccccc1C(=O)N1CCc2[nH]c(=O)n3cc(nc3c2C1)-c1ccccc1F
Show InChI InChI=1S/C22H16F2N4O2/c23-16-7-3-1-5-13(16)19-12-28-20(25-19)15-11-27(10-9-18(15)26-22(28)30)21(29)14-6-2-4-8-17(14)24/h1-8,12H,9-11H2,(H,26,30)
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n/an/an/an/a 256n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2


J Med Chem 45: 5043-51 (2002)


Article DOI: 10.1021/jm0202019
BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM50120786
PNG
(8-Benzyl-2-(3-methoxy-phenyl)-6,7,8,9-tetrahydro-5...)
Show SMILES COc1cccc(c1)-c1cn2c(n1)c1CN(Cc3ccccc3)CCc1[nH]c2=O
Show InChI InChI=1S/C23H22N4O2/c1-29-18-9-5-8-17(12-18)21-15-27-22(24-21)19-14-26(11-10-20(19)25-23(27)28)13-16-6-3-2-4-7-16/h2-9,12,15H,10-11,13-14H2,1H3,(H,25,28)
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n/an/an/an/a 268n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2


J Med Chem 45: 5043-51 (2002)


Article DOI: 10.1021/jm0202019
BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM50120805
PNG
(2-(2-Fluoro-phenyl)-8-propenyl-6,7,8,9-tetrahydro-...)
Show SMILES Fc1ccccc1-c1cn2c(n1)c1CN(CC=C)CCc1[nH]c2=O
Show InChI InChI=1S/C18H17FN4O/c1-2-8-22-9-7-15-13(10-22)17-20-16(11-23(17)18(24)21-15)12-5-3-4-6-14(12)19/h2-6,11H,1,7-10H2,(H,21,24)
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n/an/an/an/a 284n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2


J Med Chem 45: 5043-51 (2002)


Article DOI: 10.1021/jm0202019
BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM50120808
PNG
(2-(2-Fluoro-phenyl)-8-(4-methyl-benzoyl)-6,7,8,9-t...)
Show SMILES Cc1ccc(cc1)C(=O)N1CCc2[nH]c(=O)n3cc(nc3c2C1)-c1ccccc1F
Show InChI InChI=1S/C23H19FN4O2/c1-14-6-8-15(9-7-14)22(29)27-11-10-19-17(12-27)21-25-20(13-28(21)23(30)26-19)16-4-2-3-5-18(16)24/h2-9,13H,10-12H2,1H3,(H,26,30)
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Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2


J Med Chem 45: 5043-51 (2002)


Article DOI: 10.1021/jm0202019
BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM50120774
PNG
(2-(2-Fluoro-phenyl)-8-(4-methoxy-benzoyl)-6,7,8,9-...)
Show SMILES COc1ccc(cc1)C(=O)N1CCc2[nH]c(=O)n3cc(nc3c2C1)-c1ccccc1F
Show InChI InChI=1S/C23H19FN4O3/c1-31-15-8-6-14(7-9-15)22(29)27-11-10-19-17(12-27)21-25-20(13-28(21)23(30)26-19)16-4-2-3-5-18(16)24/h2-9,13H,10-12H2,1H3,(H,26,30)
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Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2


J Med Chem 45: 5043-51 (2002)


Article DOI: 10.1021/jm0202019
BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens (Human))
BDBM50052792
PNG
(CHEBI:7035 | MUSCIMOL | Muscimol)
Show SMILES NCc1cc(O)no1
Show InChI InChI=1S/C4H6N2O2/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7)
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n/an/an/an/a 407n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human GABAAalpha2beta2gamma2S receptor expressed in tsA-201cells by FLIPR membrane potential blue assay


Eur J Med Chem 84: 404-16 (2014)


Article DOI: 10.1016/j.ejmech.2014.07.039
BindingDB Entry DOI: 10.7270/Q2QV3P4Z
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens (Human))
BDBM50052792
PNG
(CHEBI:7035 | MUSCIMOL | Muscimol)
Show SMILES NCc1cc(O)no1
Show InChI InChI=1S/C4H6N2O2/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7)
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University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human GABAAalpha2beta2gamma2S receptor expressed in tsA-201cells by FLIPR membrane potential blue assay


Eur J Med Chem 84: 404-16 (2014)


Article DOI: 10.1016/j.ejmech.2014.07.039
BindingDB Entry DOI: 10.7270/Q2QV3P4Z
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens (Human))
BDBM50164569
PNG
(1-(2,4-Dichloro-phenyl)-2-(4-iodo-phenyl)-1H-imida...)
Show SMILES CCOC(=O)c1cn(c(n1)-c1ccc(I)cc1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C18H13Cl2IN2O2/c1-2-25-18(24)15-10-23(16-8-5-12(19)9-14(16)20)17(22-15)11-3-6-13(21)7-4-11/h3-10H,2H2,1H3
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Universit£ di Sassari

Curated by ChEMBL


Assay Description
Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...


J Med Chem 48: 2638-45 (2005)


Article DOI: 10.1021/jm049120y
BindingDB Entry DOI: 10.7270/Q2VH5PMS
More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM50120798
PNG
(2-(2-Fluoro-phenyl)-8-(3H-imidazol-4-ylmethyl)-6,7...)
Show SMILES Fc1ccccc1-c1cn2c(n1)c1CN(Cc3cnc[nH]3)CCc1[nH]c2=O
Show InChI InChI=1S/C19H17FN6O/c20-15-4-2-1-3-13(15)17-10-26-18(23-17)14-9-25(8-12-7-21-11-22-12)6-5-16(14)24-19(26)27/h1-4,7,10-11H,5-6,8-9H2,(H,21,22)(H,24,27)
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Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2


J Med Chem 45: 5043-51 (2002)


Article DOI: 10.1021/jm0202019
BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens (Human))
BDBM50164557
PNG
(2-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-1H-imi...)
Show SMILES CCOC(=O)c1cn(c(n1)-c1ccc(Cl)cc1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C18H13Cl3N2O2/c1-2-25-18(24)15-10-23(16-8-7-13(20)9-14(16)21)17(22-15)11-3-5-12(19)6-4-11/h3-10H,2H2,1H3
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Universit£ di Sassari

Curated by ChEMBL


Assay Description
Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...


J Med Chem 48: 2638-45 (2005)


Article DOI: 10.1021/jm049120y
BindingDB Entry DOI: 10.7270/Q2VH5PMS
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens (Human))
BDBM24183
PNG
(4-amino-n-[2,3-3H]butyric acid | 4-aminobutanoic a...)
Show SMILES NCCCC(O)=O
Show InChI InChI=1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)
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n/an/an/an/a 650n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human GABAAalpha2beta2gamma2S receptor expressed in tsA-201cells by FLIPR membrane potential blue assay


Eur J Med Chem 84: 404-16 (2014)


Article DOI: 10.1016/j.ejmech.2014.07.039
BindingDB Entry DOI: 10.7270/Q2QV3P4Z
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens (Human))
BDBM24183
PNG
(4-amino-n-[2,3-3H]butyric acid | 4-aminobutanoic a...)
Show SMILES NCCCC(O)=O
Show InChI InChI=1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)
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n/an/an/an/a 661n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human GABAAalpha2beta2gamma2S receptor expressed in tsA-201cells by FLIPR membrane potential blue assay


Eur J Med Chem 84: 404-16 (2014)


Article DOI: 10.1016/j.ejmech.2014.07.039
BindingDB Entry DOI: 10.7270/Q2QV3P4Z
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM26266
PNG
(Ambien | CHEMBL911 | Dalparan | N,N-dimethyl-2-[6-...)
Show SMILES CN(C)C(=O)Cc1c(nc2ccc(C)cn12)-c1ccc(C)cc1
Show InChI InChI=1S/C19H21N3O/c1-13-5-8-15(9-6-13)19-16(11-18(23)21(3)4)22-12-14(2)7-10-17(22)20-19/h5-10,12H,11H2,1-4H3
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n/an/an/an/a 737n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2


J Med Chem 45: 5043-51 (2002)


Article DOI: 10.1021/jm0202019
BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens (Human))
BDBM50052799
PNG
(CHEMBL3322882)
Show SMILES NC1=NCC(CC1)C(O)=O
Show InChI InChI=1S/C6H10N2O2/c7-5-2-1-4(3-8-5)6(9)10/h4H,1-3H2,(H2,7,8)(H,9,10)
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n/an/an/an/a 820n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human GABAAalpha2beta2gamma2S receptor expressed in tsA-201cells by FLIPR membrane potential blue assay


Eur J Med Chem 84: 404-16 (2014)


Article DOI: 10.1016/j.ejmech.2014.07.039
BindingDB Entry DOI: 10.7270/Q2QV3P4Z
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens (Human))
BDBM50052799
PNG
(CHEMBL3322882)
Show SMILES NC1=NCC(CC1)C(O)=O
Show InChI InChI=1S/C6H10N2O2/c7-5-2-1-4(3-8-5)6(9)10/h4H,1-3H2,(H2,7,8)(H,9,10)
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n/an/an/an/a 832n/an/an/an/a



University of Copenhagen

Curated by ChEMBL


Assay Description
Agonist activity at human GABAAalpha2beta2gamma2S receptor expressed in tsA-201cells by FLIPR membrane potential blue assay


Eur J Med Chem 84: 404-16 (2014)


Article DOI: 10.1016/j.ejmech.2014.07.039
BindingDB Entry DOI: 10.7270/Q2QV3P4Z
More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM50120771
PNG
(8-Benzyl-2-(2-thiophen-2-yl-phenyl)-6,7,8,9-tetrah...)
Show SMILES O=c1[nH]c2CCN(Cc3ccccc3)Cc2c2nc(cn12)-c1ccccc1-c1cccs1
Show InChI InChI=1S/C26H22N4OS/c31-26-28-22-12-13-29(15-18-7-2-1-3-8-18)16-21(22)25-27-23(17-30(25)26)19-9-4-5-10-20(19)24-11-6-14-32-24/h1-11,14,17H,12-13,15-16H2,(H,28,31)
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n/an/an/an/a 879n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2


J Med Chem 45: 5043-51 (2002)


Article DOI: 10.1021/jm0202019
BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens (Human))
BDBM50164579
PNG
(1-(2,4-Dichloro-phenyl)-2-p-tolyl-1H-imidazole-4-c...)
Show SMILES CCOC(=O)c1cn(c(n1)-c1ccc(C)cc1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C19H16Cl2N2O2/c1-3-25-19(24)16-11-23(17-9-8-14(20)10-15(17)21)18(22-16)13-6-4-12(2)5-7-13/h4-11H,3H2,1-2H3
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n/an/an/an/a 1.00E+3n/an/an/an/a



Universit£ di Sassari

Curated by ChEMBL


Assay Description
Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...


J Med Chem 48: 2638-45 (2005)


Article DOI: 10.1021/jm049120y
BindingDB Entry DOI: 10.7270/Q2VH5PMS
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens (Human))
BDBM50459890
PNG
(BROMOPHENE | Bromophene | CHEBI:70620)
Show SMILES Oc1c(Br)cc(Br)cc1-c1cc(Br)cc(Br)c1O
Show InChI InChI=1S/C12H6Br4O2/c13-5-1-7(11(17)9(15)3-5)8-2-6(14)4-10(16)12(8)18/h1-4,17-18H
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n/an/an/an/a 1.08E+3n/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Agonist activity at recombinant human GABAA receptor alpha2beta2gamma2L expressed in Xenopus laevis oocytes incubated for 30 secs by electrophysiolog...


Bioorg Med Chem Lett 27: 3207-3218 (2017)


Article DOI: 10.1016/j.bmcl.2017.04.073
BindingDB Entry DOI: 10.7270/Q2MC92NR
More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM50120793
PNG
(8-Cyclopropylmethyl-2-(2-fluoro-phenyl)-6,7,8,9-te...)
Show SMILES Fc1ccccc1-c1cn2c(n1)c1CN(CC3CC3)CCc1[nH]c2=O
Show InChI InChI=1S/C19H19FN4O/c20-15-4-2-1-3-13(15)17-11-24-18(21-17)14-10-23(9-12-5-6-12)8-7-16(14)22-19(24)25/h1-4,11-12H,5-10H2,(H,22,25)
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n/an/an/an/a 1.16E+3n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2


J Med Chem 45: 5043-51 (2002)


Article DOI: 10.1021/jm0202019
BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
GABA A receptor alpha-2/beta-2/gamma-2


(Homo sapiens (Human))
BDBM50120792
PNG
(8-Benzyl-2-p-tolyl-6,7,8,9-tetrahydro-5H-1,3a,5,8-...)
Show SMILES Cc1ccc(cc1)-c1cn2c(n1)c1CN(Cc3ccccc3)CCc1[nH]c2=O
Show InChI InChI=1S/C23H22N4O/c1-16-7-9-18(10-8-16)21-15-27-22(24-21)19-14-26(12-11-20(19)25-23(27)28)13-17-5-3-2-4-6-17/h2-10,15H,11-14H2,1H3,(H,25,28)
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n/an/an/an/a 1.18E+3n/an/an/an/a



Neurogen Corporation

Curated by ChEMBL


Assay Description
Effective concentration against gamma-aminobutyric acid (GABA) A receptor, alpha 2


J Med Chem 45: 5043-51 (2002)


Article DOI: 10.1021/jm0202019
BindingDB Entry DOI: 10.7270/Q2DR2TTC
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens (Human))
BDBM50164562
PNG
(CHEMBL192127 | [2-(4-Chloro-phenyl)-1-(2,4-dichlor...)
Show SMILES CN1CCN(CC1)C(=O)c1cn(c(n1)-c1ccc(Cl)cc1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C21H19Cl3N4O/c1-26-8-10-27(11-9-26)21(29)18-13-28(19-7-6-16(23)12-17(19)24)20(25-18)14-2-4-15(22)5-3-14/h2-7,12-13H,8-11H2,1H3
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n/an/an/an/a 1.30E+3n/an/an/an/a



Universit£ di Sassari

Curated by ChEMBL


Assay Description
Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...


J Med Chem 48: 2638-45 (2005)


Article DOI: 10.1021/jm049120y
BindingDB Entry DOI: 10.7270/Q2VH5PMS
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-2/gamma-2 subunit


(Homo sapiens (Human))
BDBM50164558
PNG
(1,2-Bis-(4-chloro-phenyl)-1H-imidazole-4-carboxyli...)
Show SMILES CCOC(=O)c1cn(c(n1)-c1ccc(Cl)cc1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C18H14Cl2N2O2/c1-2-24-18(23)16-11-22(15-9-7-14(20)8-10-15)17(21-16)12-3-5-13(19)6-4-12/h3-11H,2H2,1H3
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n/an/an/an/a 1.50E+3n/an/an/an/a



Universit£ di Sassari

Curated by ChEMBL


Assay Description
Effective concentration against GABA-evoked chloride currents mediated by human Gamma-aminobutyric acid GABA-A receptor alpha2-beta2-gamma2L expresse...


J Med Chem 48: 2638-45 (2005)


Article DOI: 10.1021/jm049120y
BindingDB Entry DOI: 10.7270/Q2VH5PMS
More data for this
Ligand-Target Pair
GABA receptor alpha-2/beta-3/gamma-2 subunit


(Homo sapiens (Human))
BDBM86521
PNG
(CAS_5719 | NSC_5719 | Zaleplon)
Show SMILES CCN(C(C)=O)c1cccc(c1)-c1ccnc2c(cnn12)C#N
Show InChI InChI=1S/C17H15N5O/c1-3-21(12(2)23)15-6-4-5-13(9-15)16-7-8-19-17-14(10-18)11-20-22(16)17/h4-9,11H,3H2,1-2H3
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n/an/an/an/a 1.63E+3n/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Modulation of human GABAA alpha2beta3gamma2 expressed in xenopus oocytes assessed as potentiation of GABA-evoked chloride currents


J Med Chem 56: 593-624 (2013)


Article DOI: 10.1021/jm3011433
BindingDB Entry DOI: 10.7270/Q23B61GZ
More data for this
Ligand-Target Pair
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