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Compile Data Set for Download or QSAR

Found 158 hits of ic50 for UniProtKB: A0A024RDK3   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
CaM kinase II


(Homo sapiens (Human))
BDBM149450
PNG
(US8975250, 32)
Show SMILES CCn1c(N)c(C(N)=O)c(=O)c2cnc(Nc3ccc(cc3OC)N3CCC(CC3)N3CCOCC3)nc12
Show InChI InChI=1S/C26H34N8O4/c1-3-34-23(27)21(24(28)36)22(35)18-15-29-26(31-25(18)34)30-19-5-4-17(14-20(19)37-2)32-8-6-16(7-9-32)33-10-12-38-13-11-33/h4-5,14-16H,3,6-13,27H2,1-2H3,(H2,28,36)(H,29,30,31)
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n/an/a 2n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The kinase activity of CaMKII beta is evaluated by means of a radioactive test on the recombinant CaMKII beta enzyme. The amount of ATP-gamma 33P in...


US Patent US8975250 (2015)


BindingDB Entry DOI: 10.7270/Q2Z31XD8
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens-Homo sapiens (Human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Lilly Spain S.A.

Curated by ChEMBL


Assay Description
Inhibitory activity against Cyclin D1-cyclin-dependent kinase 4 by measuring the phosphorylation of RbING


Bioorg Med Chem Lett 13: 3835-9 (2003)


Article DOI: 10.1016/s0960-894x(03)00791-1
BindingDB Entry DOI: 10.7270/Q2Z89BTC
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50361927
PNG
(CHEMBL1939161)
Show SMILES CN1CCCC1CCNc1nc(Nc2ccc(Cl)c(Cl)c2)nc2ccc(Cl)cc12
Show InChI InChI=1S/C21H22Cl3N5/c1-29-10-2-3-15(29)8-9-25-20-16-11-13(22)4-7-19(16)27-21(28-20)26-14-5-6-17(23)18(24)12-14/h4-7,11-12,15H,2-3,8-10H2,1H3,(H2,25,26,27,28)
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University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CAMK2delta using tetramethylbenzidine as substrate by spectrophotometry analysis


Bioorg Med Chem 20: 377-400 (2011)


Article DOI: 10.1016/j.bmc.2011.10.071
BindingDB Entry DOI: 10.7270/Q2959J05
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens-Homo sapiens (Human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 4n/an/an/an/an/an/a



Lilly Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of Protein kinase C beta 1


Bioorg Med Chem Lett 13: 1857-9 (2003)


Article DOI: 10.1016/s0960-894x(03)00286-5
BindingDB Entry DOI: 10.7270/Q2319V87
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens-Homo sapiens (Human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 6n/an/an/an/an/an/a



Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL


Assay Description
Inhibition of Calcium/calmodulin-dependent protein kinase type II


Bioorg Med Chem Lett 13: 3049-53 (2003)


Article DOI: 10.1016/s0960-894x(03)00644-9
BindingDB Entry DOI: 10.7270/Q2DR2TVT
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM149454
PNG
(US8975250, 61)
Show SMILES CCn1c(N)c(C(N)=O)c(=O)c2cnc(Nc3ccc(N4CCC(CC4)N4CCCC4)c(Cl)c3)nc12
Show InChI InChI=1S/C25H31ClN8O2/c1-2-34-22(27)20(23(28)36)21(35)17-14-29-25(31-24(17)34)30-15-5-6-19(18(26)13-15)33-11-7-16(8-12-33)32-9-3-4-10-32/h5-6,13-14,16H,2-4,7-12,27H2,1H3,(H2,28,36)(H,29,30,31)
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n/an/a 8n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The kinase activity of CaMKII beta is evaluated by means of a radioactive test on the recombinant CaMKII beta enzyme. The amount of ATP-gamma 33P in...


US Patent US8975250 (2015)


BindingDB Entry DOI: 10.7270/Q2Z31XD8
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50374977
PNG
(CHEMBL270849)
Show SMILES Clc1cccc(Nc2nccc(n2)-c2cccc(c2)N2CCNCC2)c1
Show InChI InChI=1S/C20H20ClN5/c21-16-4-2-5-17(14-16)24-20-23-8-7-19(25-20)15-3-1-6-18(13-15)26-11-9-22-10-12-26/h1-8,13-14,22H,9-12H2,(H,23,24,25)
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n/an/a 9n/an/an/an/an/an/a



Scios, Inc.

Curated by ChEMBL


Assay Description
Inhibition of cloned CaMK2delta


Bioorg Med Chem Lett 18: 2404-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.056
BindingDB Entry DOI: 10.7270/Q2CN74S6
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50375063
PNG
(CHEMBL255607)
Show SMILES NCCc1cn(C2=C(C(=O)NC2=O)c2c[nH]c3ccc(Cl)cc23)c2ccccc12
Show InChI InChI=1S/C22H17ClN4O2/c23-13-5-6-17-15(9-13)16(10-25-17)19-20(22(29)26-21(19)28)27-11-12(7-8-24)14-3-1-2-4-18(14)27/h1-6,9-11,25H,7-8,24H2,(H,26,28,29)
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n/an/a 10n/an/an/an/an/an/a



Scios, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CaMK2delta


Bioorg Med Chem Lett 18: 2399-403 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.057
BindingDB Entry DOI: 10.7270/Q2M61M4W
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50374956
PNG
(CHEMBL272978)
Show SMILES NCCNc1cccc(c1)-c1ccnc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C18H18ClN5/c19-14-4-2-6-16(12-14)23-18-22-9-7-17(24-18)13-3-1-5-15(11-13)21-10-8-20/h1-7,9,11-12,21H,8,10,20H2,(H,22,23,24)
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n/an/a 12n/an/an/an/an/an/a



Scios, Inc.

Curated by ChEMBL


Assay Description
Inhibition of cloned CaMK2delta


Bioorg Med Chem Lett 18: 2404-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.056
BindingDB Entry DOI: 10.7270/Q2CN74S6
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50375073
PNG
(CHEMBL402340)
Show SMILES CNCCc1cn(C2=C(C(=O)NC2=O)c2c[nH]c3ccc(Cl)cc23)c2ccccc12
Show InChI InChI=1S/C23H19ClN4O2/c1-25-9-8-13-12-28(19-5-3-2-4-15(13)19)21-20(22(29)27-23(21)30)17-11-26-18-7-6-14(24)10-16(17)18/h2-7,10-12,25-26H,8-9H2,1H3,(H,27,29,30)
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n/an/a 13n/an/an/an/an/an/a



Scios, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CaMK2delta


Bioorg Med Chem Lett 18: 2399-403 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.057
BindingDB Entry DOI: 10.7270/Q2M61M4W
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM149449
PNG
(US8975250, 29)
Show SMILES CCn1c(N)c(C(N)=O)c(=O)c2cnc(Nc3ccc(cc3OC)C3CCN(CC3)C3CC3)nc12
Show InChI InChI=1S/C25H31N7O3/c1-3-32-22(26)20(23(27)34)21(33)17-13-28-25(30-24(17)32)29-18-7-4-15(12-19(18)35-2)14-8-10-31(11-9-14)16-5-6-16/h4,7,12-14,16H,3,5-6,8-11,26H2,1-2H3,(H2,27,34)(H,28,29,30)
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n/an/a 17n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The kinase activity of CaMKII beta is evaluated by means of a radioactive test on the recombinant CaMKII beta enzyme. The amount of ATP-gamma 33P in...


US Patent US8975250 (2015)


BindingDB Entry DOI: 10.7270/Q2Z31XD8
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50375061
PNG
(CHEMBL271648)
Show SMILES CNCCc1cn(C2=C(C(=O)NC2=O)c2c[nH]c3ccc(cc23)C(=O)OC)c2ccccc12
Show InChI InChI=1S/C25H22N4O4/c1-26-10-9-15-13-29(20-6-4-3-5-16(15)20)22-21(23(30)28-24(22)31)18-12-27-19-8-7-14(11-17(18)19)25(32)33-2/h3-8,11-13,26-27H,9-10H2,1-2H3,(H,28,30,31)
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n/an/a 21n/an/an/an/an/an/a



Scios, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CaMK2delta


Bioorg Med Chem Lett 18: 2399-403 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.057
BindingDB Entry DOI: 10.7270/Q2M61M4W
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM149451
PNG
(US8975250, 35)
Show SMILES CCn1c(N)c(C(N)=O)c(=O)c2cnc(Nc3ccc(cc3OC)C3CCN(CCC(F)(F)F)CC3)nc12
Show InChI InChI=1S/C25H30F3N7O3/c1-3-35-21(29)19(22(30)37)20(36)16-13-31-24(33-23(16)35)32-17-5-4-15(12-18(17)38-2)14-6-9-34(10-7-14)11-8-25(26,27)28/h4-5,12-14H,3,6-11,29H2,1-2H3,(H2,30,37)(H,31,32,33)
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n/an/a 22n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The kinase activity of CaMKII beta is evaluated by means of a radioactive test on the recombinant CaMKII beta enzyme. The amount of ATP-gamma 33P in...


US Patent US8975250 (2015)


BindingDB Entry DOI: 10.7270/Q2Z31XD8
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens-Homo sapiens (Human))
BDBM2672
PNG
(3,13,23-triazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^...)
Show SMILES O=C1NC(=O)c2c1c1c3ccccc3[nH]c1c1[nH]c3ccccc3c21
Show InChI InChI=1S/C20H11N3O2/c24-19-15-13-9-5-1-3-7-11(9)21-17(13)18-14(16(15)20(25)23-19)10-6-2-4-8-12(10)22-18/h1-8,21-22H,(H,23,24,25)
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n/an/a 25n/an/an/an/an/an/a



Lilly Spain S.A.

Curated by ChEMBL


Assay Description
Inhibition of Cyclin E-cyclin-dependent kinase 2


Bioorg Med Chem Lett 13: 3835-9 (2003)


Article DOI: 10.1016/s0960-894x(03)00791-1
BindingDB Entry DOI: 10.7270/Q2Z89BTC
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens-Homo sapiens (Human))
BDBM50217536
PNG
(CHEMBL2369378)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCCCNC(=O)OCc1ccccc1[N+]([O-])=O)NC(=O)[C@@H](N)CCCCNC(=O)OCc1ccccc1[N+]([O-])=O)C(C)C)C(O)=O
Show InChI InChI=1S/C80H126N24O27/c1-41(2)36-55(99-64(110)44(7)91-68(114)50(23-15-17-33-90-80(125)131-40-48-21-11-13-27-59(48)104(128)129)94-67(113)49(81)22-14-16-32-89-79(124)130-39-47-20-10-12-26-58(47)103(126)127)74(120)96-52(25-19-35-88-78(85)86)70(116)95-51(24-18-34-87-77(83)84)71(117)97-53(28-30-60(82)105)72(118)98-54(29-31-61(106)107)69(115)92-46(9)66(112)102-63(43(5)6)75(121)100-56(38-62(108)109)73(119)93-45(8)65(111)101-57(76(122)123)37-42(3)4/h10-13,20-21,26-27,41-46,49-57,63H,14-19,22-25,28-40,81H2,1-9H3,(H2,82,105)(H,89,124)(H,90,125)(H,91,114)(H,92,115)(H,93,119)(H,94,113)(H,95,116)(H,96,120)(H,97,117)(H,98,118)(H,99,110)(H,100,121)(H,101,111)(H,102,112)(H,106,107)(H,108,109)(H,122,123)(H4,83,84,87)(H4,85,86,88)/t44-,45-,46-,49-,50-,51-,52-,53-,54-,55-,56-,57-,63-/m0/s1
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n/an/a 32n/an/an/an/an/an/a



Osaka National Research Institute, AIST, Ikeda, Japan.

Curated by ChEMBL


Assay Description
Inhibitory activity of compound against CaMKII


Bioorg Med Chem Lett 9: 1093-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00140-7
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50375062
PNG
(CHEMBL402533)
Show SMILES NCCc1cn(C2=C(C(=O)NC2=O)c2c[nH]c3ccc(cc23)C(F)(F)F)c2ccccc12
Show InChI InChI=1S/C23H17F3N4O2/c24-23(25,26)13-5-6-17-15(9-13)16(10-28-17)19-20(22(32)29-21(19)31)30-11-12(7-8-27)14-3-1-2-4-18(14)30/h1-6,9-11,28H,7-8,27H2,(H,29,31,32)
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n/an/a 32n/an/an/an/an/an/a



Scios, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CaMK2delta


Bioorg Med Chem Lett 18: 2399-403 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.057
BindingDB Entry DOI: 10.7270/Q2M61M4W
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50374982
PNG
(CHEMBL403446)
Show SMILES NCCCn1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccc(Br)cc23)c2ccccc12
Show InChI InChI=1S/C23H19BrN4O2/c24-13-6-7-18-15(10-13)16(11-26-18)20-21(23(30)27-22(20)29)17-12-28(9-3-8-25)19-5-2-1-4-14(17)19/h1-2,4-7,10-12,26H,3,8-9,25H2,(H,27,29,30)
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n/an/a 34n/an/an/an/an/an/a



Scios, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CaMK2delta


Bioorg Med Chem Lett 18: 2395-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.058
BindingDB Entry DOI: 10.7270/Q2QZ2BVW
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50374982
PNG
(CHEMBL403446)
Show SMILES NCCCn1cc(C2=C(C(=O)NC2=O)c2c[nH]c3ccc(Br)cc23)c2ccccc12
Show InChI InChI=1S/C23H19BrN4O2/c24-13-6-7-18-15(10-13)16(11-26-18)20-21(23(30)27-22(20)29)17-12-28(9-3-8-25)19-5-2-1-4-14(17)19/h1-2,4-7,10-12,26H,3,8-9,25H2,(H,27,29,30)
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n/an/a 34n/an/an/an/an/an/a



Scios, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CaMK2delta


Bioorg Med Chem Lett 18: 2390-4 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.059
BindingDB Entry DOI: 10.7270/Q27W6D2W
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens-Homo sapiens (Human))
BDBM50217537
PNG
(CHEMBL385035)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)OCc1ccccc1[N+]([O-])=O)C(C)C)C(O)=O
Show InChI InChI=1S/C69H116N22O22/c1-35(2)31-47(86-55(97)38(7)79-57(99)41(18-11-13-27-70)81-60(102)44(19-12-14-28-71)89-69(110)113-34-40-17-9-10-22-50(40)91(111)112)64(106)83-43(21-16-30-78-68(75)76)58(100)82-42(20-15-29-77-67(73)74)59(101)84-45(23-25-51(72)92)61(103)85-46(24-26-52(93)94)62(104)90-54(37(5)6)65(107)87-48(33-53(95)96)63(105)80-39(8)56(98)88-49(66(108)109)32-36(3)4/h9-10,17,22,35-39,41-49,54H,11-16,18-21,23-34,70-71H2,1-8H3,(H2,72,92)(H,79,99)(H,80,105)(H,81,102)(H,82,100)(H,83,106)(H,84,101)(H,85,103)(H,86,97)(H,87,107)(H,88,98)(H,89,110)(H,90,104)(H,93,94)(H,95,96)(H,108,109)(H4,73,74,77)(H4,75,76,78)/t38-,39-,41-,42-,43-,44-,45-,46-,47-,48-,49-,54-/m0/s1
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n/an/a 36n/an/an/an/an/an/a



Osaka National Research Institute, AIST, Ikeda, Japan.

Curated by ChEMBL


Assay Description
Inhibitory activity of compound against CaMKII


Bioorg Med Chem Lett 9: 1093-6 (1999)


Article DOI: 10.1016/s0960-894x(99)00140-7
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM149455
PNG
(US8975250, 75)
Show SMILES CCn1c(N)c(C(N)=O)c(=O)c2cnc(Nc3ccc4CNCCc4c3)nc12
Show InChI InChI=1S/C19H21N7O2/c1-2-26-16(20)14(17(21)28)15(27)13-9-23-19(25-18(13)26)24-12-4-3-11-8-22-6-5-10(11)7-12/h3-4,7,9,22H,2,5-6,8,20H2,1H3,(H2,21,28)(H,23,24,25)
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n/an/a 37n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The kinase activity of CaMKII beta is evaluated by means of a radioactive test on the recombinant CaMKII beta enzyme. The amount of ATP-gamma 33P in...


US Patent US8975250 (2015)


BindingDB Entry DOI: 10.7270/Q2Z31XD8
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50375072
PNG
(CHEMBL403337)
Show SMILES NCCc1cn(C2=C(C(=O)NC2=O)c2c[nH]c3ccc(F)cc23)c2ccccc12
Show InChI InChI=1S/C22H17FN4O2/c23-13-5-6-17-15(9-13)16(10-25-17)19-20(22(29)26-21(19)28)27-11-12(7-8-24)14-3-1-2-4-18(14)27/h1-6,9-11,25H,7-8,24H2,(H,26,28,29)
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n/an/a 38n/an/an/an/an/an/a



Scios, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CaMK2delta


Bioorg Med Chem Lett 18: 2399-403 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.057
BindingDB Entry DOI: 10.7270/Q2M61M4W
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM149459
PNG
(US8975250, 113)
Show SMILES COc1cc(ccc1Nc1ncc2c(n1)n(c(N)c(C(N)=O)c2=O)-c1ccccc1)C1CCNCC1
Show InChI InChI=1S/C26H27N7O3/c1-36-20-13-16(15-9-11-29-12-10-15)7-8-19(20)31-26-30-14-18-22(34)21(24(28)35)23(27)33(25(18)32-26)17-5-3-2-4-6-17/h2-8,13-15,29H,9-12,27H2,1H3,(H2,28,35)(H,30,31,32)
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n/an/a 39n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The kinase activity of CaMKII beta is evaluated by means of a radioactive test on the recombinant CaMKII beta enzyme. The amount of ATP-gamma 33P in...


US Patent US8975250 (2015)


BindingDB Entry DOI: 10.7270/Q2Z31XD8
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50374954
PNG
(CHEMBL271045)
Show SMILES OC(=O)c1ccc(cc1)-c1ccnc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C17H12ClN3O2/c18-13-2-1-3-14(10-13)20-17-19-9-8-15(21-17)11-4-6-12(7-5-11)16(22)23/h1-10H,(H,22,23)(H,19,20,21)
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n/an/a 42n/an/an/an/an/an/a



Scios, Inc.

Curated by ChEMBL


Assay Description
Inhibition of cloned CaMK2delta


Bioorg Med Chem Lett 18: 2404-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.056
BindingDB Entry DOI: 10.7270/Q2CN74S6
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50375071
PNG
(CHEMBL270032)
Show SMILES NCCc1cn(C2=C(C(=O)NC2=O)c2c[nH]c3ccc(cc23)C#N)c2ccccc12
Show InChI InChI=1S/C23H17N5O2/c24-8-7-14-12-28(19-4-2-1-3-15(14)19)21-20(22(29)27-23(21)30)17-11-26-18-6-5-13(10-25)9-16(17)18/h1-6,9,11-12,26H,7-8,24H2,(H,27,29,30)
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n/an/a 46n/an/an/an/an/an/a



Scios, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CaMK2delta


Bioorg Med Chem Lett 18: 2399-403 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.057
BindingDB Entry DOI: 10.7270/Q2M61M4W
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM149460
PNG
(US8975250, 114)
Show SMILES COc1cc(ccc1Nc1ncc2c(n1)n(CCO)c(N)c(C(N)=O)c2=O)C1CCNCC1
Show InChI InChI=1S/C22H27N7O4/c1-33-16-10-13(12-4-6-25-7-5-12)2-3-15(16)27-22-26-11-14-18(31)17(20(24)32)19(23)29(8-9-30)21(14)28-22/h2-3,10-12,25,30H,4-9,23H2,1H3,(H2,24,32)(H,26,27,28)
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n/an/a 57n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The kinase activity of CaMKII beta is evaluated by means of a radioactive test on the recombinant CaMKII beta enzyme. The amount of ATP-gamma 33P in...


US Patent US8975250 (2015)


BindingDB Entry DOI: 10.7270/Q2Z31XD8
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50374963
PNG
(CHEMBL402428)
Show SMILES OC(=O)c1ccc(cc1)-c1ccnc(Nc2ccccc2)n1
Show InChI InChI=1S/C17H13N3O2/c21-16(22)13-8-6-12(7-9-13)15-10-11-18-17(20-15)19-14-4-2-1-3-5-14/h1-11H,(H,21,22)(H,18,19,20)
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n/an/a 64n/an/an/an/an/an/a



Scios, Inc.

Curated by ChEMBL


Assay Description
Inhibition of cloned CaMK2delta


Bioorg Med Chem Lett 18: 2404-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.056
BindingDB Entry DOI: 10.7270/Q2CN74S6
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50374965
PNG
(CHEMBL255617)
Show SMILES Nc1cc(Nc2nccc(n2)-c2ccc(cc2)C(O)=O)ccn1
Show InChI InChI=1S/C16H13N5O2/c17-14-9-12(5-7-18-14)20-16-19-8-6-13(21-16)10-1-3-11(4-2-10)15(22)23/h1-9H,(H,22,23)(H3,17,18,19,20,21)
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n/an/a 66n/an/an/an/an/an/a



Scios, Inc.

Curated by ChEMBL


Assay Description
Inhibition of cloned CaMK2delta


Bioorg Med Chem Lett 18: 2404-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.056
BindingDB Entry DOI: 10.7270/Q2CN74S6
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50361928
PNG
(CHEMBL1939162)
Show SMILES CCN1CCCC(C1)Nc1nc(Nc2cc(Cl)cc(Cl)c2)nc2ccc(Cl)cc12
Show InChI InChI=1S/C21H22Cl3N5/c1-2-29-7-3-4-16(12-29)25-20-18-11-13(22)5-6-19(18)27-21(28-20)26-17-9-14(23)8-15(24)10-17/h5-6,8-11,16H,2-4,7,12H2,1H3,(H2,25,26,27,28)
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n/an/a 82n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CAMK2delta using tetramethylbenzidine as substrate by spectrophotometry analysis


Bioorg Med Chem 20: 377-400 (2011)


Article DOI: 10.1016/j.bmc.2011.10.071
BindingDB Entry DOI: 10.7270/Q2959J05
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50374956
PNG
(CHEMBL272978)
Show SMILES NCCNc1cccc(c1)-c1ccnc(Nc2cccc(Cl)c2)n1
Show InChI InChI=1S/C18H18ClN5/c19-14-4-2-6-16(12-14)23-18-22-9-7-17(24-18)13-3-1-5-15(11-13)21-10-8-20/h1-7,9,11-12,21H,8,10,20H2,(H,22,23,24)
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n/an/a 110n/an/an/an/an/an/a



Scios, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CaMK2delta-mediated vimentin phosphorylation in human HL2 cells after 1 hr by ELISA


Bioorg Med Chem Lett 18: 2404-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.056
BindingDB Entry DOI: 10.7270/Q2CN74S6
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50375070
PNG
(CHEMBL411724)
Show SMILES CCc1ccc2[nH]cc(C3=C(C(=O)NC3=O)n3cc(CCNC)c4ccccc34)c2c1
Show InChI InChI=1S/C25H24N4O2/c1-3-15-8-9-20-18(12-15)19(13-27-20)22-23(25(31)28-24(22)30)29-14-16(10-11-26-2)17-6-4-5-7-21(17)29/h4-9,12-14,26-27H,3,10-11H2,1-2H3,(H,28,30,31)
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n/an/a 110n/an/an/an/an/an/a



Scios, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CaMK2delta


Bioorg Med Chem Lett 18: 2399-403 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.057
BindingDB Entry DOI: 10.7270/Q2M61M4W
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50375077
PNG
(CHEMBL430412)
Show SMILES NCCc1cn(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc12
Show InChI InChI=1S/C22H18N4O2/c23-10-9-13-12-26(18-8-4-2-5-14(13)18)20-19(21(27)25-22(20)28)16-11-24-17-7-3-1-6-15(16)17/h1-8,11-12,24H,9-10,23H2,(H,25,27,28)
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n/an/a 110n/an/an/an/an/an/a



Scios, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CaMK2delta


Bioorg Med Chem Lett 18: 2399-403 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.057
BindingDB Entry DOI: 10.7270/Q2M61M4W
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM149456
PNG
(US8975250, 76)
Show SMILES CCn1c(N)c(C(N)=O)c(=O)c2cnc(Nc3ccc(OC4CCN(C)CC4)cc3)nc12
Show InChI InChI=1S/C22H27N7O3/c1-3-29-19(23)17(20(24)31)18(30)16-12-25-22(27-21(16)29)26-13-4-6-14(7-5-13)32-15-8-10-28(2)11-9-15/h4-7,12,15H,3,8-11,23H2,1-2H3,(H2,24,31)(H,25,26,27)
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n/an/a 118n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The kinase activity of CaMKII beta is evaluated by means of a radioactive test on the recombinant CaMKII beta enzyme. The amount of ATP-gamma 33P in...


US Patent US8975250 (2015)


BindingDB Entry DOI: 10.7270/Q2Z31XD8
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM149452
PNG
(US8975250, 52)
Show SMILES CC(C)Cn1c(N)c(C(N)=O)c(=O)c2cnc(Nc3ccc(CCN4CCOCC4)cc3)nc12
Show InChI InChI=1S/C24H31N7O3/c1-15(2)14-31-21(25)19(22(26)33)20(32)18-13-27-24(29-23(18)31)28-17-5-3-16(4-6-17)7-8-30-9-11-34-12-10-30/h3-6,13,15H,7-12,14,25H2,1-2H3,(H2,26,33)(H,27,28,29)
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n/an/a 139n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The kinase activity of CaMKII beta is evaluated by means of a radioactive test on the recombinant CaMKII beta enzyme. The amount of ATP-gamma 33P in...


US Patent US8975250 (2015)


BindingDB Entry DOI: 10.7270/Q2Z31XD8
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50375064
PNG
(CHEMBL402152)
Show SMILES CNCCc1cn(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc12
Show InChI InChI=1S/C23H20N4O2/c1-24-11-10-14-13-27(19-9-5-3-6-15(14)19)21-20(22(28)26-23(21)29)17-12-25-18-8-4-2-7-16(17)18/h2-9,12-13,24-25H,10-11H2,1H3,(H,26,28,29)
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n/an/a 150n/an/an/an/an/an/a



Scios, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CaMK2delta


Bioorg Med Chem Lett 18: 2399-403 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.057
BindingDB Entry DOI: 10.7270/Q2M61M4W
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50361934
PNG
(CHEMBL1939328)
Show SMILES CCCCCNc1nc(Nc2ccc(cc2)[N+]([O-])=O)nc(n1)N1CCN(CCN(C)C)CC1
Show InChI InChI=1S/C22H35N9O2/c1-4-5-6-11-23-20-25-21(24-18-7-9-19(10-8-18)31(32)33)27-22(26-20)30-16-14-29(15-17-30)13-12-28(2)3/h7-10H,4-6,11-17H2,1-3H3,(H2,23,24,25,26,27)
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n/an/a 154n/an/an/an/an/an/a



University of Jordan

Curated by ChEMBL


Assay Description
Inhibition of human recombinant CAMK2delta using tetramethylbenzidine as substrate by spectrophotometry analysis


Bioorg Med Chem 20: 377-400 (2011)


Article DOI: 10.1016/j.bmc.2011.10.071
BindingDB Entry DOI: 10.7270/Q2959J05
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50374966
PNG
(CHEMBL402524)
Show SMILES C[C@H](Nc1cc(Nc2nccc(n2)-c2ccc(cc2)C(=O)NO)ccn1)c1ccccc1
Show InChI InChI=1S/C24H22N6O2/c1-16(17-5-3-2-4-6-17)27-22-15-20(11-13-25-22)28-24-26-14-12-21(29-24)18-7-9-19(10-8-18)23(31)30-32/h2-16,32H,1H3,(H,30,31)(H2,25,26,27,28,29)/t16-/m0/s1
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n/an/a 170n/an/an/an/an/an/a



Scios, Inc.

Curated by ChEMBL


Assay Description
Inhibition of cloned CaMK2delta


Bioorg Med Chem Lett 18: 2404-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.056
BindingDB Entry DOI: 10.7270/Q2CN74S6
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50375069
PNG
(CHEMBL271426)
Show SMILES COc1ccc2[nH]cc(C3=C(C(=O)NC3=O)n3cc(CCN)c4ccccc34)c2c1
Show InChI InChI=1S/C23H20N4O3/c1-30-14-6-7-18-16(10-14)17(11-25-18)20-21(23(29)26-22(20)28)27-12-13(8-9-24)15-4-2-3-5-19(15)27/h2-7,10-12,25H,8-9,24H2,1H3,(H,26,28,29)
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n/an/a 170n/an/an/an/an/an/a



Scios, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CaMK2delta


Bioorg Med Chem Lett 18: 2399-403 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.057
BindingDB Entry DOI: 10.7270/Q2M61M4W
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50374989
PNG
(CHEMBL412302)
Show SMILES NCCCn1cc(C2=C(C(=O)NC2=O)c2cccc(Br)c2)c2ccccc12
Show InChI InChI=1S/C21H18BrN3O2/c22-14-6-3-5-13(11-14)18-19(21(27)24-20(18)26)16-12-25(10-4-9-23)17-8-2-1-7-15(16)17/h1-3,5-8,11-12H,4,9-10,23H2,(H,24,26,27)
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n/an/a 180n/an/an/an/an/an/a



Scios, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CaMK2delta


Bioorg Med Chem Lett 18: 2395-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.058
BindingDB Entry DOI: 10.7270/Q2QZ2BVW
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50374989
PNG
(CHEMBL412302)
Show SMILES NCCCn1cc(C2=C(C(=O)NC2=O)c2cccc(Br)c2)c2ccccc12
Show InChI InChI=1S/C21H18BrN3O2/c22-14-6-3-5-13(11-14)18-19(21(27)24-20(18)26)16-12-25(10-4-9-23)17-8-2-1-7-15(16)17/h1-3,5-8,11-12H,4,9-10,23H2,(H,24,26,27)
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n/an/a 180n/an/an/an/an/an/a



Scios, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CaMK2delta


Bioorg Med Chem Lett 18: 2390-4 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.059
BindingDB Entry DOI: 10.7270/Q27W6D2W
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens-Homo sapiens (Human))
BDBM2581
PNG
(3,13,23-triazahexacyclo[14.7.0.0^{2,10}.0^{4,9}.0^...)
Show SMILES O=C1NCc2c1c1c3ccccc3[nH]c1c1[nH]c3ccccc3c21
Show InChI InChI=1S/C20H13N3O/c24-20-17-12(9-21-20)15-10-5-1-3-7-13(10)22-18(15)19-16(17)11-6-2-4-8-14(11)23-19/h1-8,22-23H,9H2,(H,21,24)
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n/an/a 184n/an/an/an/an/an/a



Lilly Spain S.A.

Curated by ChEMBL


Assay Description
Inhibitory activity against Cyclin D1-cyclin-dependent kinase 4 by measuring the phosphorylation of RbING


Bioorg Med Chem Lett 13: 3835-9 (2003)


Article DOI: 10.1016/s0960-894x(03)00791-1
BindingDB Entry DOI: 10.7270/Q2Z89BTC
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50375067
PNG
(CHEMBL271043)
Show SMILES CNCCc1cn(C2=C(C(=O)NC2=O)c2c[nH]c3ccc(cc23)C(N)=O)c2ccccc12
Show InChI InChI=1S/C24H21N5O3/c1-26-9-8-14-12-29(19-5-3-2-4-15(14)19)21-20(23(31)28-24(21)32)17-11-27-18-7-6-13(22(25)30)10-16(17)18/h2-7,10-12,26-27H,8-9H2,1H3,(H2,25,30)(H,28,31,32)
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n/an/a 190n/an/an/an/an/an/a



Scios, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CaMK2delta


Bioorg Med Chem Lett 18: 2399-403 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.057
BindingDB Entry DOI: 10.7270/Q2M61M4W
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50375080
PNG
(CHEMBL270141)
Show SMILES NCCCc1cn(C2=C(C(=O)NC2=O)c2c[nH]c3ccccc23)c2ccccc12
Show InChI InChI=1S/C23H20N4O2/c24-11-5-6-14-13-27(19-10-4-2-7-15(14)19)21-20(22(28)26-23(21)29)17-12-25-18-9-3-1-8-16(17)18/h1-4,7-10,12-13,25H,5-6,11,24H2,(H,26,28,29)
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n/an/a 190n/an/an/an/an/an/a



Scios, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CaMK2delta


Bioorg Med Chem Lett 18: 2399-403 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.057
BindingDB Entry DOI: 10.7270/Q2M61M4W
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50374972
PNG
(CHEMBL403766)
Show SMILES C[C@H](Nc1cc(Nc2nccc(n2)-c2ccc(cc2)C(O)=O)ccn1)c1ccccc1
Show InChI InChI=1S/C24H21N5O2/c1-16(17-5-3-2-4-6-17)27-22-15-20(11-13-25-22)28-24-26-14-12-21(29-24)18-7-9-19(10-8-18)23(30)31/h2-16H,1H3,(H,30,31)(H2,25,26,27,28,29)/t16-/m0/s1
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n/an/a 210n/an/an/an/an/an/a



Scios, Inc.

Curated by ChEMBL


Assay Description
Inhibition of cloned CaMK2delta


Bioorg Med Chem Lett 18: 2404-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.056
BindingDB Entry DOI: 10.7270/Q2CN74S6
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50374997
PNG
(CHEMBL256827)
Show SMILES NCCCn1cc(C2=C(C(=O)NC2=O)c2ccccc2)c2ccccc12
Show InChI InChI=1S/C21H19N3O2/c22-11-6-12-24-13-16(15-9-4-5-10-17(15)24)19-18(20(25)23-21(19)26)14-7-2-1-3-8-14/h1-5,7-10,13H,6,11-12,22H2,(H,23,25,26)
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n/an/a 230n/an/an/an/an/an/a



Scios, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CaMK2delta using 3 weeks old stock solution of compound


Bioorg Med Chem Lett 18: 2399-403 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.057
BindingDB Entry DOI: 10.7270/Q2M61M4W
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50374952
PNG
(CHEMBL403054)
Show SMILES Clc1cccc(Nc2nccc(n2)-c2cccc(c2)N2CCOCC2)c1
Show InChI InChI=1S/C20H19ClN4O/c21-16-4-2-5-17(14-16)23-20-22-8-7-19(24-20)15-3-1-6-18(13-15)25-9-11-26-12-10-25/h1-8,13-14H,9-12H2,(H,22,23,24)
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n/an/a 240n/an/an/an/an/an/a



Scios, Inc.

Curated by ChEMBL


Assay Description
Inhibition of cloned CaMK2delta


Bioorg Med Chem Lett 18: 2404-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.056
BindingDB Entry DOI: 10.7270/Q2CN74S6
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM149448
PNG
(US8975250, 4)
Show SMILES CCn1c(N)c(C(N)=O)c(=O)c2cnc(Nc3ccc(cc3)C(=O)N3CCN(C)CC3)nc12
Show InChI InChI=1S/C22H26N8O3/c1-3-30-18(23)16(19(24)32)17(31)15-12-25-22(27-20(15)30)26-14-6-4-13(5-7-14)21(33)29-10-8-28(2)9-11-29/h4-7,12H,3,8-11,23H2,1-2H3,(H2,24,32)(H,25,26,27)
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n/an/a 260n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The kinase activity of CaMKII beta is evaluated by means of a radioactive test on the recombinant CaMKII beta enzyme. The amount of ATP-gamma 33P in...


US Patent US8975250 (2015)


BindingDB Entry DOI: 10.7270/Q2Z31XD8
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM149457
PNG
(US8975250, 78)
Show SMILES CCn1c(N)c(C(N)=O)c(=O)c2cnc(Nc3cccc(CN(C)C)c3)nc12
Show InChI InChI=1S/C19H23N7O2/c1-4-26-16(20)14(17(21)28)15(27)13-9-22-19(24-18(13)26)23-12-7-5-6-11(8-12)10-25(2)3/h5-9H,4,10,20H2,1-3H3,(H2,21,28)(H,22,23,24)
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n/an/a 268n/an/an/an/an/an/a



SANOFI

US Patent


Assay Description
The kinase activity of CaMKII beta is evaluated by means of a radioactive test on the recombinant CaMKII beta enzyme. The amount of ATP-gamma 33P in...


US Patent US8975250 (2015)


BindingDB Entry DOI: 10.7270/Q2Z31XD8
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50374988
PNG
(CHEMBL408434)
Show SMILES Cc1cccc(c1)C1=C(C(=O)NC1=O)c1cn(CCCN)c2ccccc12
Show InChI InChI=1S/C22H21N3O2/c1-14-6-4-7-15(12-14)19-20(22(27)24-21(19)26)17-13-25(11-5-10-23)18-9-3-2-8-16(17)18/h2-4,6-9,12-13H,5,10-11,23H2,1H3,(H,24,26,27)
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n/an/a 280n/an/an/an/an/an/a



Scios, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CaMK2delta


Bioorg Med Chem Lett 18: 2390-4 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.059
BindingDB Entry DOI: 10.7270/Q27W6D2W
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50375066
PNG
(CHEMBL256460)
Show SMILES CNCCc1cn(C2=C(C(=O)NC2=O)c2c[nH]c3ccc(cc23)C(=O)NC)c2ccccc12
Show InChI InChI=1S/C25H23N5O3/c1-26-10-9-15-13-30(20-6-4-3-5-16(15)20)22-21(24(32)29-25(22)33)18-12-28-19-8-7-14(11-17(18)19)23(31)27-2/h3-8,11-13,26,28H,9-10H2,1-2H3,(H,27,31)(H,29,32,33)
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n/an/a 280n/an/an/an/an/an/a



Scios, Inc.

Curated by ChEMBL


Assay Description
Inhibition of CaMK2delta


Bioorg Med Chem Lett 18: 2399-403 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.057
BindingDB Entry DOI: 10.7270/Q2M61M4W
More data for this
Ligand-Target Pair
CaM kinase II


(Homo sapiens (Human))
BDBM50374960
PNG
(CHEMBL255633)
Show SMILES ONC(=O)c1ccc(cc1)-c1ccnc(Nc2ccccc2)n1
Show InChI InChI=1S/C17H14N4O2/c22-16(21-23)13-8-6-12(7-9-13)15-10-11-18-17(20-15)19-14-4-2-1-3-5-14/h1-11,23H,(H,21,22)(H,18,19,20)
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Scios, Inc.

Curated by ChEMBL


Assay Description
Inhibition of cloned CaMK2delta


Bioorg Med Chem Lett 18: 2404-8 (2008)


Article DOI: 10.1016/j.bmcl.2008.02.056
BindingDB Entry DOI: 10.7270/Q2CN74S6
More data for this
Ligand-Target Pair
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