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Compile Data Set for Download or QSAR

Found 1384 hits of ic50 for UniProtKB: A0A024RCR5   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM313791
PNG
(US10167292, Example 35)
Show SMILES C[C@H](NC(=O)c1ccc2-c3c(C)nnn3CCN(c3ccc(Cl)cc3)c2c1)c1ccccc1
Show InChI InChI=1S/C26H24ClN5O/c1-17(19-6-4-3-5-7-19)28-26(33)20-8-13-23-24(16-20)31(22-11-9-21(27)10-12-22)14-15-32-25(23)18(2)29-30-32/h3-13,16-17H,14-15H2,1-2H3,(H,28,33)/t17-/m0/s1
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n/an/a 3n/an/an/an/an/an/a



Walter and Eliza Hall Institute of Medical Research

Curated by ChEMBL


Assay Description
Inhibition of human His-tagged Brd2 bromodomain 2 expressed in Escherichia coli BL21 (DE3) preincubated for 30 mins followed by addition of biotinyla...


ACS Med Chem Lett 8: 1298-1303 (2017)


Article DOI: 10.1021/acsmedchemlett.7b00389
BindingDB Entry DOI: 10.7270/Q2JQ13K2
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM50459819
PNG
(CHEMBL4228445)
Show SMILES CCn1nc(cc1Nc1nc(nc2[nH]c3cc(-c4c(C)noc4C)c(OC)cc3c12)C(=O)NC)C1CC1
Show InChI InChI=1S/C26H28N8O3/c1-6-34-20(11-17(32-34)14-7-8-14)29-24-22-15-10-19(36-5)16(21-12(2)33-37-13(21)3)9-18(15)28-23(22)30-25(31-24)26(35)27-4/h9-11,14H,6-8H2,1-5H3,(H,27,35)(H2,28,29,30,31)
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n/an/a 3.10n/an/an/an/an/an/a



University of Michigan Comprehensive Cancer Center

Curated by ChEMBL


Assay Description
Inhibition of FAM-labeled ZBA248 binding to recombinant N-terminal His6-tagged BRD2 bromodomain 1 (72 to 205 residues) (unknown origin) expressed in ...


J Med Chem 61: 462-481 (2018)


Article DOI: 10.1021/acs.jmedchem.6b01816
BindingDB Entry DOI: 10.7270/Q2CV4MD0
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM50028142
PNG
(CHEMBL2177300)
Show SMILES C[C@H]1C[C@@H](Nc2ccc(Cl)cc2)c2cc(ccc2N1C(C)=O)-c1ccc(cc1)C(O)=O
Show InChI InChI=1S/C25H23ClN2O3/c1-15-13-23(27-21-10-8-20(26)9-11-21)22-14-19(7-12-24(22)28(15)16(2)29)17-3-5-18(6-4-17)25(30)31/h3-12,14-15,23,27H,13H2,1-2H3,(H,30,31)/t15-,23+/m0/s1
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n/an/a 3.20n/an/an/an/an/an/a



GlaxoSmithKline

Curated by ChEMBL


Assay Description
Inhibition of human BRD2 bromodomain 2 by BROMOscan assay


J Med Chem 57: 8111-31 (2014)


Article DOI: 10.1021/jm5010539
BindingDB Entry DOI: 10.7270/Q23R0VGR
More data for this
Ligand-Target Pair
Bromodomain and extra-terminal motif (BET)


(Homo sapiens (Human))
BDBM50520653
PNG
(CHEMBL4555209)
Show SMILES Cc1nnc2COCc3c(Cc4ccccc4)c(sc3-n12)C#Cc1cnn(C)c1
Show InChI InChI=1S/C22H19N5OS/c1-15-24-25-21-14-28-13-19-18(10-16-6-4-3-5-7-16)20(29-22(19)27(15)21)9-8-17-11-23-26(2)12-17/h3-7,11-12H,10,13-14H2,1-2H3
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n/an/a 3.5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity to human BRD2 BD1 (72 to 205 residues) by fluorescence polarization assay


J Med Chem 61: 6685-6704 (2018)


Article DOI: 10.1021/acs.jmedchem.8b00506
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM50459819
PNG
(CHEMBL4228445)
Show SMILES CCn1nc(cc1Nc1nc(nc2[nH]c3cc(-c4c(C)noc4C)c(OC)cc3c12)C(=O)NC)C1CC1
Show InChI InChI=1S/C26H28N8O3/c1-6-34-20(11-17(32-34)14-7-8-14)29-24-22-15-10-19(36-5)16(21-12(2)33-37-13(21)3)9-18(15)28-23(22)30-25(31-24)26(35)27-4/h9-11,14H,6-8H2,1-5H3,(H,27,35)(H2,28,29,30,31)
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n/an/a 3.90n/an/an/an/an/an/a



University of Michigan Comprehensive Cancer Center

Curated by ChEMBL


Assay Description
Inhibition of FAM-labeled ZBA248 binding to recombinant N-terminal His6-tagged BRD2 bromodomain 2 (349 to 460 residues) (unknown origin) expressed in...


J Med Chem 61: 462-481 (2018)


Article DOI: 10.1021/acs.jmedchem.6b01816
BindingDB Entry DOI: 10.7270/Q2CV4MD0
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM313789
PNG
(US10167292, Example 33)
Show SMILES C[C@H](NC(=O)c1ccc2-c3c(C)nnn3CCN(c3ccc(Cl)cc3)c2c1)c1ccc(F)cc1
Show InChI InChI=1S/C26H23ClFN5O/c1-16(18-3-8-21(28)9-4-18)29-26(34)19-5-12-23-24(15-19)32(22-10-6-20(27)7-11-22)13-14-33-25(23)17(2)30-31-33/h3-12,15-16H,13-14H2,1-2H3,(H,29,34)/t16-/m0/s1
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Walter and Eliza Hall Institute of Medical Research

Curated by ChEMBL


Assay Description
Inhibition of human His-tagged Brd2 bromodomain 2 expressed in Escherichia coli BL21 (DE3) preincubated for 30 mins followed by addition of biotinyla...


ACS Med Chem Lett 8: 1298-1303 (2017)


Article DOI: 10.1021/acsmedchemlett.7b00389
BindingDB Entry DOI: 10.7270/Q2JQ13K2
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM313807
PNG
(US10167292, Example 51B)
Show SMILES Cc1nnn2CCN(c3ccc(Cl)cc3)c3cc(ccc3-c12)-c1nn[nH]n1
Show InChI InChI=1S/C18H15ClN8/c1-11-17-15-7-2-12(18-21-23-24-22-18)10-16(15)26(8-9-27(17)25-20-11)14-5-3-13(19)4-6-14/h2-7,10H,8-9H2,1H3,(H,21,22,23,24)
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Walter and Eliza Hall Institute of Medical Research

Curated by ChEMBL


Assay Description
Inhibition of human His-tagged Brd2 bromodomain 1 expressed in Escherichia coli BL21 (DE3) preincubated for 30 mins followed by addition of biotinyla...


ACS Med Chem Lett 8: 1298-1303 (2017)


Article DOI: 10.1021/acsmedchemlett.7b00389
BindingDB Entry DOI: 10.7270/Q2JQ13K2
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM313807
PNG
(US10167292, Example 51B)
Show SMILES Cc1nnn2CCN(c3ccc(Cl)cc3)c3cc(ccc3-c12)-c1nn[nH]n1
Show InChI InChI=1S/C18H15ClN8/c1-11-17-15-7-2-12(18-21-23-24-22-18)10-16(15)26(8-9-27(17)25-20-11)14-5-3-13(19)4-6-14/h2-7,10H,8-9H2,1H3,(H,21,22,23,24)
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Walter and Eliza Hall Institute of Medical Research

Curated by ChEMBL


Assay Description
Inhibition of human His-tagged Brd2 bromodomain 2 expressed in Escherichia coli BL21 (DE3) preincubated for 30 mins followed by addition of biotinyla...


ACS Med Chem Lett 8: 1298-1303 (2017)


Article DOI: 10.1021/acsmedchemlett.7b00389
BindingDB Entry DOI: 10.7270/Q2JQ13K2
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM380670
PNG
(6-(4-chlorophenyl)-2-cyclopropyl-5-(3,8-dimethyl-[...)
Show SMILES Cc1nnc2c(C)cc(cn12)N1C(c2c(nc(C3CC3)n2C)C1=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H21ClN6O/c1-12-10-17(11-29-13(2)26-27-21(12)29)30-19(14-6-8-16(24)9-7-14)20-18(23(30)31)25-22(28(20)3)15-4-5-15/h6-11,15,19H,4-5H2,1-3H3
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n/an/a<11n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)


BindingDB Entry DOI: 10.7270/Q2TM7DFQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM380694
PNG
((R)-6-(4-chlorophenyl)-2-(3,6-dihydro-2H-pyran-4-y...)
Show SMILES CC(C)n1c(nc2C(=O)N([C@@H](c12)c1ccc(Cl)cc1)c1cc(C)c2nnn(C)c2c1)C1=CCOCC1
Show InChI InChI=1S/C27H27ClN6O2/c1-15(2)33-25-23(29-26(33)18-9-11-36-12-10-18)27(35)34(24(25)17-5-7-19(28)8-6-17)20-13-16(3)22-21(14-20)32(4)31-30-22/h5-9,13-15,24H,10-12H2,1-4H3/t24-/m1/s1
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Novartis AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)


BindingDB Entry DOI: 10.7270/Q2TM7DFQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM318840
PNG
((R)-6-4-chlorophenyl)-3-cyclopropyl-5-(3,8-dimethy...)
Show SMILES CNC1=C(C(=N)C2CC2)C(=O)N([C@@H]1c1ccc(Cl)cc1)c1cc(C)c2nnc(C)n2c1
Show InChI InChI=1S/C23H23ClN6O/c1-12-10-17(11-29-13(2)27-28-22(12)29)30-21(15-6-8-16(24)9-7-15)20(26-3)18(23(30)31)19(25)14-4-5-14/h6-11,14,21,25-26H,4-5H2,1-3H3/t21-/m1/s1
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Novartis AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9624247 (2017)


BindingDB Entry DOI: 10.7270/Q28S4S02
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM318855
PNG
((R)-6-(4-chlorophenyl)-3-cyclopropyl-5-(3-(fluorom...)
Show SMILES Cc1cc(cn2c(CF)nnc12)N1[C@@H](c2c(C1=O)c(nn2C)C1CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H20ClFN6O/c1-12-9-16(11-30-17(10-25)26-27-22(12)30)31-20(14-5-7-15(24)8-6-14)21-18(23(31)32)19(13-3-4-13)28-29(21)2/h5-9,11,13,20H,3-4,10H2,1-2H3/t20-/m1/s1
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Novartis AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9624247 (2017)


BindingDB Entry DOI: 10.7270/Q28S4S02
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM318861
PNG
((R)-6-(4-chlorophenyl)-3-cyclopropyl-5-(3,8-dimeth...)
Show SMILES Cc1nnc2c(C)cc(nn12)N1[C@@H](c2c(C1=O)c(nn2C)C1CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H20ClN7O/c1-11-10-16(26-30-12(2)24-25-21(11)30)29-19(14-6-8-15(23)9-7-14)20-17(22(29)31)18(13-4-5-13)27-28(20)3/h6-10,13,19H,4-5H2,1-3H3/t19-/m1/s1
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Novartis AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9624247 (2017)


BindingDB Entry DOI: 10.7270/Q28S4S02
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM380716
PNG
((R)-6-(4-chlorophenyl)-2-(3,6-dihydro-2H-pyran-4-y...)
Show SMILES CC(C)n1c(nc2C(=O)N([C@@H](c12)c1ccc(Cl)cc1)c1cc(C)c2nnc(C)n2n1)C1=CCOCC1
Show InChI InChI=1S/C26H26ClN7O2/c1-14(2)32-23-21(28-25(32)18-9-11-36-12-10-18)26(35)33(22(23)17-5-7-19(27)8-6-17)20-13-15(3)24-30-29-16(4)34(24)31-20/h5-9,13-14,22H,10-12H2,1-4H3/t22-/m1/s1
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Novartis AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)


BindingDB Entry DOI: 10.7270/Q2TM7DFQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM150062
PNG
(US8975417, 122)
Show SMILES Cc1nn(C2CC2)c2C(=O)N([C@@H](c12)c1ccc(Cl)cc1)c1cc(C)c2nnc(C)n2n1
Show InChI InChI=1S/C22H20ClN7O/c1-11-10-17(27-29-13(3)24-25-21(11)29)28-19(14-4-6-15(23)7-5-14)18-12(2)26-30(16-8-9-16)20(18)22(28)31/h4-7,10,16,19H,8-9H2,1-3H3/t19-/m1/s1
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Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM380723
PNG
((R)-6-(4-chlorophenyl)-5-(3,8-dimethyl-[1,2,4]tria...)
Show SMILES CC(C)n1c(C)nc2C(=O)N([C@@H](c12)c1ccc(Cl)cc1)c1cc(C)c2nnc(C)n2n1
Show InChI InChI=1S/C22H22ClN7O/c1-11(2)28-13(4)24-18-20(28)19(15-6-8-16(23)9-7-15)29(22(18)31)17-10-12(3)21-26-25-14(5)30(21)27-17/h6-11,19H,1-5H3/t19-/m1/s1
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Novartis AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)


BindingDB Entry DOI: 10.7270/Q2TM7DFQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM380725
PNG
((R)-6-(4-chlorophenyl)-5-(1,4-dimethyl-1H-benzo[d]...)
Show SMILES COc1ncccc1-c1nc2C(=O)N([C@@H](c2n1C(C)C)c1ccc(Cl)cc1)c1cc(C)c2nnn(C)c2c1
Show InChI InChI=1S/C28H26ClN7O2/c1-15(2)35-25-23(31-26(35)20-7-6-12-30-27(20)38-5)28(37)36(24(25)17-8-10-18(29)11-9-17)19-13-16(3)22-21(14-19)34(4)33-32-22/h6-15,24H,1-5H3/t24-/m1/s1
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Novartis AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)


BindingDB Entry DOI: 10.7270/Q2TM7DFQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM380695
PNG
((R)-6-(4-chlorophenyl)-5-(1,4-dimethyl-1H-benzo[d]...)
Show SMILES CC(C)n1c(nc2C(=O)N([C@@H](c12)c1ccc(Cl)cc1)c1cc(C)c2nnn(C)c2c1)C1CCOCC1
Show InChI InChI=1S/C27H29ClN6O2/c1-15(2)33-25-23(29-26(33)18-9-11-36-12-10-18)27(35)34(24(25)17-5-7-19(28)8-6-17)20-13-16(3)22-21(14-20)32(4)31-30-22/h5-8,13-15,18,24H,9-12H2,1-4H3/t24-/m1/s1
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Novartis AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)


BindingDB Entry DOI: 10.7270/Q2TM7DFQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM318841
PNG
(6-(4-chlorophenyl)-3-cyclopropyl-5-(3-(difluoromet...)
Show SMILES Cc1cc(cn2c(nnc12)C(F)F)N1C(c2c(C1=O)c(nn2C)C1CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H19ClF2N6O/c1-11-9-15(10-31-21(11)27-28-22(31)20(25)26)32-18(13-5-7-14(24)8-6-13)19-16(23(32)33)17(12-3-4-12)29-30(19)2/h5-10,12,18,20H,3-4H2,1-2H3
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n/an/a 13n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9624247 (2017)


BindingDB Entry DOI: 10.7270/Q28S4S02
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM318858
PNG
((R)-6-(4-chlorophenyl)-3-cyclopropyl-5-(3,8-dimeth...)
Show SMILES Cc1nnc2c(C)cc(cn12)N1[C@@H](c2c(C1=O)c(nn2C[C@H](O)C(F)(F)F)C1CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H22ClF3N6O2/c1-12-9-17(10-33-13(2)30-31-23(12)33)35-21(15-5-7-16(26)8-6-15)22-19(24(35)37)20(14-3-4-14)32-34(22)11-18(36)25(27,28)29/h5-10,14,18,21,36H,3-4,11H2,1-2H3/t18-,21+/m0/s1
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Novartis AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9624247 (2017)


BindingDB Entry DOI: 10.7270/Q28S4S02
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM318845
PNG
((R)-6-(4-chlorophenyl)-3-cyclopropyl-5-(3-(difluor...)
Show SMILES Cc1cc(cn2c(nnc12)C(F)F)N1[C@@H](c2c(C1=O)c(nn2C)C1CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H19ClF2N6O/c1-11-9-15(10-31-21(11)27-28-22(31)20(25)26)32-18(13-5-7-14(24)8-6-13)19-16(23(32)33)17(12-3-4-12)29-30(19)2/h5-10,12,18,20H,3-4H2,1-2H3/t18-/m1/s1
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Novartis AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9624247 (2017)


BindingDB Entry DOI: 10.7270/Q28S4S02
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM380731
PNG
((R)-6-(4-chlorophenyl)-5-(3,7-dimethyl-3H-benzo[d]...)
Show SMILES CC(C)n1c(C)nc2[C@H](N(C(=O)c12)c1cc(C)c2nnn(C)c2c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H23ClN6O/c1-12(2)29-14(4)25-20-21(15-6-8-16(24)9-7-15)30(23(31)22(20)29)17-10-13(3)19-18(11-17)28(5)27-26-19/h6-12,21H,1-5H3/t21-/m1/s1
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Novartis AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)


BindingDB Entry DOI: 10.7270/Q2TM7DFQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM150047
PNG
(US8975417, 107)
Show SMILES CCc1nn(C2CC2)c2C(=O)N([C@@H](c12)c1ccc(Cl)cc1)c1cc(C)c2nnc(C)n2c1
Show InChI InChI=1S/C24H23ClN6O/c1-4-19-20-21(15-5-7-16(25)8-6-15)30(24(32)22(20)31(28-19)17-9-10-17)18-11-13(2)23-27-26-14(3)29(23)12-18/h5-8,11-12,17,21H,4,9-10H2,1-3H3/t21-/m1/s1
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Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM150044
PNG
(US8975417, 104)
Show SMILES CC(C)n1nc(C)c2[C@H](N(C(=O)c12)c1cc(C)c(=O)n(C)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C22H23ClN4O2/c1-12(2)27-20-18(14(4)24-27)19(15-6-8-16(23)9-7-15)26(22(20)29)17-10-13(3)21(28)25(5)11-17/h6-12,19H,1-5H3/t19-/m1/s1
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Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM380763
PNG
((R)-6-(4-chlorophenyl)-5-(3-(difluoromethyl)-8-met...)
Show SMILES COc1ncccc1-c1nc2C(=O)N([C@@H](c2n1C(C)C)c1ccc(Cl)cc1)c1cc(C)c2nnc(C(F)F)n2c1
Show InChI InChI=1S/C28H24ClF2N7O2/c1-14(2)37-22-20(33-25(37)19-6-5-11-32-27(19)40-4)28(39)38(21(22)16-7-9-17(29)10-8-16)18-12-15(3)24-34-35-26(23(30)31)36(24)13-18/h5-14,21,23H,1-4H3/t21-/m1/s1
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Novartis AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)


BindingDB Entry DOI: 10.7270/Q2TM7DFQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM264434
PNG
(6-(4-chlorophenyl)-3-cyclopropyl-5-(1,5-dimethyl-6...)
Show SMILES COCCNC1=C(C(=N)C2CC2)C(=O)N(C1c1ccc(Cl)cc1)c1cc(C)c(=O)n(C)c1
Show InChI InChI=1S/C24H27ClN4O3/c1-14-12-18(13-28(2)23(14)30)29-22(16-6-8-17(25)9-7-16)21(27-10-11-32-3)19(24(29)31)20(26)15-4-5-15/h6-9,12-13,15,22,26-27H,4-5,10-11H2,1-3H3
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Novartis AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9714249 (2017)


BindingDB Entry DOI: 10.7270/Q27083FW
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149993
PNG
(US8975417, 49)
Show SMILES Cc1nn(C2CC2)c2C(=O)N([C@@H](c12)c1ccc(Cl)cc1)c1cc(C)c(=O)n(C)c1
Show InChI InChI=1S/C22H21ClN4O2/c1-12-10-17(11-25(3)21(12)28)26-19(14-4-6-15(23)7-5-14)18-13(2)24-27(16-8-9-16)20(18)22(26)29/h4-7,10-11,16,19H,8-9H2,1-3H3/t19-/m1/s1
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Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM380654
PNG
((R)-6-(4-chlorophenyl)-5-(1,5-dimethyl-6-oxo-1,6-d...)
Show SMILES CCn1c(nc2[C@H](N(C(=O)c12)c1cc(C)c(=O)n(C)c1)c1ccc(Cl)cc1)-c1cccnc1OC
Show InChI InChI=1S/C26H24ClN5O3/c1-5-31-22-20(29-23(31)19-7-6-12-28-24(19)35-4)21(16-8-10-17(27)11-9-16)32(26(22)34)18-13-15(2)25(33)30(3)14-18/h6-14,21H,5H2,1-4H3/t21-/m1/s1
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n/an/a 15.5n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)


BindingDB Entry DOI: 10.7270/Q2TM7DFQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM380768
PNG
((R)-6-(4-chlorophenyl)-5-(3,7-dimethyl-3H-[1,2,3]t...)
Show SMILES COc1ncccc1-c1nc2C(=O)N([C@@H](c2n1C(C)C)c1ccc(Cl)cc1)c1cc(C)c2nnn(C)c2n1
Show InChI InChI=1S/C27H25ClN8O2/c1-14(2)35-23-21(31-24(35)18-7-6-12-29-26(18)38-5)27(37)36(22(23)16-8-10-17(28)11-9-16)19-13-15(3)20-25(30-19)34(4)33-32-20/h6-14,22H,1-5H3/t22-/m1/s1
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Novartis AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)


BindingDB Entry DOI: 10.7270/Q2TM7DFQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM380769
PNG
((R)-6-(4-chlorophenyl)-5-(3-(difluoromethyl)-8-met...)
Show SMILES COc1ncc(-c2nc3C(=O)N([C@@H](c3n2C(C)C)c2ccc(Cl)cc2)c2cc(C)c3nnc(C(F)F)n3c2)c(OC)n1
Show InChI InChI=1S/C28H25ClF2N8O3/c1-13(2)38-21-19(33-24(38)18-11-32-28(42-5)34-26(18)41-4)27(40)39(20(21)15-6-8-16(29)9-7-15)17-10-14(3)23-35-36-25(22(30)31)37(23)12-17/h6-13,20,22H,1-5H3/t20-/m1/s1
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Novartis AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)


BindingDB Entry DOI: 10.7270/Q2TM7DFQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM150102
PNG
(US8975417, 170)
Show SMILES CCn1nc(C)c2C(N(C(=O)c12)c1cc(C)c(=O)n(C)c1)c1ccc(Cl)cc1F
Show InChI InChI=1S/C21H20ClFN4O2/c1-5-26-19-17(12(3)24-26)18(15-7-6-13(22)9-16(15)23)27(21(19)29)14-8-11(2)20(28)25(4)10-14/h6-10,18H,5H2,1-4H3
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Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM318854
PNG
(6-(4-chlorophenyl)-3-cyclopropyl-5-(3-(fluoromethy...)
Show SMILES Cc1cc(cn2c(CF)nnc12)N1C(c2c(C1=O)c(nn2C)C1CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H20ClFN6O/c1-12-9-16(11-30-17(10-25)26-27-22(12)30)31-20(14-5-7-15(24)8-6-14)21-18(23(31)32)19(13-3-4-13)28-29(21)2/h5-9,11,13,20H,3-4,10H2,1-2H3
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Novartis AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9624247 (2017)


BindingDB Entry DOI: 10.7270/Q28S4S02
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM150133
PNG
(US8975417, 166)
Show SMILES Cc1nnc2c(C)cc(cn12)N1[C@@H](c2c(CO)nn(C3CC3)c2C1=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H21ClN6O2/c1-12-9-17(10-28-13(2)25-26-22(12)28)29-20(14-3-5-15(24)6-4-14)19-18(11-31)27-30(16-7-8-16)21(19)23(29)32/h3-6,9-10,16,20,31H,7-8,11H2,1-2H3/t20-/m1/s1
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Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM50210164
PNG
(CHEMBL2132936)
Show SMILES Cc1nnc2C(CC(=O)OC(C)(C)C)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3
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n/an/a 16n/an/an/an/an/an/a



Walter and Eliza Hall Institute of Medical Research

Curated by ChEMBL


Assay Description
Inhibition of human His-tagged Brd2 bromodomain 2 expressed in Escherichia coli BL21 (DE3) preincubated for 30 mins followed by addition of biotinyla...


ACS Med Chem Lett 8: 1298-1303 (2017)


Article DOI: 10.1021/acsmedchemlett.7b00389
BindingDB Entry DOI: 10.7270/Q2JQ13K2
More data for this
Ligand-Target Pair
Bromodomain and extra-terminal motif (BET)


(Homo sapiens (Human))
BDBM50210164
PNG
(CHEMBL2132936)
Show SMILES Cc1nnc2C(CC(=O)OC(C)(C)C)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3
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n/an/a 17n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of His/thioredoxin-tagged human recombinant BRD4 bromodomain-1 (43 to 166 residues) expressed in Escherichia coli BL21 Star (DE3) pre-incu...


J Med Chem 60: 9990-10012 (2017)


Article DOI: 10.1021/acs.jmedchem.7b00275
BindingDB Entry DOI: 10.7270/Q2M32Z68
More data for this
Ligand-Target Pair
Bromodomain and extra-terminal motif (BET)


(Homo sapiens (Human))
BDBM50365262
PNG
( (S)-JQ1 (1) | CHEMBL1957266 | JQ1 | US10124009, C...)
Show SMILES Cc1nnc2[C@H](CC(=O)OC(C)(C)C)N=C(c3c(C)c(C)sc3-n12)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3/t17-/m0/s1
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n/an/a 17n/an/an/an/an/an/a



Sichuan University and Collaborative Innovation Center of Biotherapy

Curated by ChEMBL


Assay Description
Inhibition of human recombinant His-tagged BRD2 BD2 domain expressed in Escherichia coli BL21(DE3)-R3-pRARE2 cells by AlphaScreen assay


J Med Chem 63: 3678-3700 (2020)


Article DOI: 10.1021/acs.jmedchem.9b02178
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM380778
PNG
((R)-6-(4-chlorophenyl)-5-(3-(difluoromethyl)-8-met...)
Show SMILES COc1ncccc1-c1nc2C(=O)N([C@@H](c2n1C(C)C)c1ccc(Cl)cc1)c1cc(C)c2nnc(C(F)F)n2n1
Show InChI InChI=1S/C27H23ClF2N8O2/c1-13(2)36-21-19(32-24(36)17-6-5-11-31-26(17)40-4)27(39)37(20(21)15-7-9-16(28)10-8-15)18-12-14(3)23-33-34-25(22(29)30)38(23)35-18/h5-13,20,22H,1-4H3/t20-/m1/s1
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Novartis AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)


BindingDB Entry DOI: 10.7270/Q2TM7DFQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM313798
PNG
(US10167292, Example 42)
Show SMILES Cc1nnn2CCN(c3ccc(Cl)cc3)c3cc(ccc3-c12)C(N)=O
Show InChI InChI=1S/C18H16ClN5O/c1-11-17-15-7-2-12(18(20)25)10-16(15)23(8-9-24(17)22-21-11)14-5-3-13(19)4-6-14/h2-7,10H,8-9H2,1H3,(H2,20,25)
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n/an/a 17n/an/an/an/an/an/a



Walter and Eliza Hall Institute of Medical Research

Curated by ChEMBL


Assay Description
Inhibition of human His-tagged Brd2 bromodomain 2 expressed in Escherichia coli BL21 (DE3) preincubated for 30 mins followed by addition of biotinyla...


ACS Med Chem Lett 8: 1298-1303 (2017)


Article DOI: 10.1021/acsmedchemlett.7b00389
BindingDB Entry DOI: 10.7270/Q2JQ13K2
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM149995
PNG
(US8975417, 51)
Show SMILES Cc1nn(C2CC2)c2C(=O)N([C@@H](c12)c1ccc(Cl)cc1)c1cc(Cl)c(=O)n(C)c1
Show InChI InChI=1S/C21H18Cl2N4O2/c1-11-17-18(12-3-5-13(22)6-4-12)26(15-9-16(23)20(28)25(2)10-15)21(29)19(17)27(24-11)14-7-8-14/h3-6,9-10,14,18H,7-8H2,1-2H3/t18-/m1/s1
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n/an/a 17n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM380693
PNG
(6-(4-chlorophenyl)-5-(1,4-dimethyl-1H-benzo[d][1,2...)
Show SMILES CC(C)n1c(nc2C(=O)N(C(c12)c1ccc(Cl)cc1)c1cc(C)c2nnn(C)c2c1)C1CCOCC1
Show InChI InChI=1S/C27H29ClN6O2/c1-15(2)33-25-23(29-26(33)18-9-11-36-12-10-18)27(35)34(24(25)17-5-7-19(28)8-6-17)20-13-16(3)22-21(14-20)32(4)31-30-22/h5-8,13-15,18,24H,9-12H2,1-4H3
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Novartis AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)


BindingDB Entry DOI: 10.7270/Q2TM7DFQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM150132
PNG
(US8975417, 165)
Show SMILES Cc1n[nH]c2C(=O)N([C@@H](c12)c1ccc(Cl)cc1)c1cc(C)c2nnc(C)n2c1
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n/an/a 17n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM318842
PNG
(6-(4-chlorophenyl)-3-cyclopropyl-5-(3-(difluoromet...)
Show SMILES COCCn1nc(C2CC2)c2C(=O)N(C(c12)c1ccc(Cl)cc1)c1cc(C)c2nnc(C)n2c1
Show InChI InChI=1S/C25H25ClN6O2/c1-14-12-19(13-30-15(2)27-28-24(14)30)32-22(17-6-8-18(26)9-7-17)23-20(25(32)33)21(16-4-5-16)29-31(23)10-11-34-3/h6-9,12-13,16,22H,4-5,10-11H2,1-3H3
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Novartis AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9624247 (2017)


BindingDB Entry DOI: 10.7270/Q28S4S02
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM380658
PNG
((R)-6-(4-chlorophenyl)-5-(1,5-dimethyl-6-oxo-1,6-d...)
Show SMILES COc1ncccc1-c1nc2[C@H](N(C(=O)c2n1C(C)C)c1cc(C)c(=O)n(C)c1)c1ccc(Cl)cc1
Show InChI InChI=1S/C27H26ClN5O3/c1-15(2)32-23-21(30-24(32)20-7-6-12-29-25(20)36-5)22(17-8-10-18(28)11-9-17)33(27(23)35)19-13-16(3)26(34)31(4)14-19/h6-15,22H,1-5H3/t22-/m1/s1
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Novartis AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)


BindingDB Entry DOI: 10.7270/Q2TM7DFQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM150050
PNG
(US8975417, 110)
Show SMILES Cc1nn(C2CC2)c2C(=O)N(C(c12)c1ccc(Cl)cc1)c1cc(C)c2nnn(C)c2n1
Show InChI InChI=1S/C22H20ClN7O/c1-11-10-16(24-21-18(11)25-27-28(21)3)29-19(13-4-6-14(23)7-5-13)17-12(2)26-30(15-8-9-15)20(17)22(29)31/h4-7,10,15,19H,8-9H2,1-3H3
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n/an/a 18n/an/an/an/a7.530



Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM313792
PNG
(US10167292, Example 36)
Show SMILES Cc1nnn2CCN(c3ccc(Cl)cc3)c3cc(ccc3-c12)C(=O)Nc1ccccc1
Show InChI InChI=1S/C24H20ClN5O/c1-16-23-21-12-7-17(24(31)26-19-5-3-2-4-6-19)15-22(21)29(13-14-30(23)28-27-16)20-10-8-18(25)9-11-20/h2-12,15H,13-14H2,1H3,(H,26,31)
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n/an/a 18n/an/an/an/an/an/a



Walter and Eliza Hall Institute of Medical Research

Curated by ChEMBL


Assay Description
Inhibition of human His-tagged Brd2 bromodomain 2 expressed in Escherichia coli BL21 (DE3) preincubated for 30 mins followed by addition of biotinyla...


ACS Med Chem Lett 8: 1298-1303 (2017)


Article DOI: 10.1021/acsmedchemlett.7b00389
BindingDB Entry DOI: 10.7270/Q2JQ13K2
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM380744
PNG
(6-(4-chlorophenyl)-5-(3-(difluoromethyl)-8-methyl-...)
Show SMILES COc1ncccc1-c1nc2C(=O)N(C(c2n1C(C)C)c1ccc(Cl)cc1)c1cc(C)c2nnc(C(F)F)n2c1
Show InChI InChI=1S/C28H24ClF2N7O2/c1-14(2)37-22-20(33-25(37)19-6-5-11-32-27(19)40-4)28(39)38(21(22)16-7-9-17(29)10-8-16)18-12-15(3)24-34-35-26(23(30)31)36(24)13-18/h5-14,21,23H,1-4H3
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Novartis AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)


BindingDB Entry DOI: 10.7270/Q2TM7DFQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM150059
PNG
(US8975417, 119)
Show SMILES Cc1nn(C2CC2)c2C(=O)N([C@@H](c12)c1ccc(Cl)cc1)c1cc(C)c2nnc(C)n2c1
Show InChI InChI=1S/C23H21ClN6O/c1-12-10-18(11-28-14(3)25-26-22(12)28)29-20(15-4-6-16(24)7-5-15)19-13(2)27-30(17-8-9-17)21(19)23(29)31/h4-7,10-11,17,20H,8-9H2,1-3H3/t20-/m1/s1
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Novartis AG

US Patent


Assay Description
All assays were performed in 384-well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US8975417 (2015)


BindingDB Entry DOI: 10.7270/Q2NK3CRX
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM380699
PNG
(6-(4-chlorophenyl)-5-(3,8-dimethyl-[1,2,4]triazolo...)
Show SMILES CC(C)n1c(nc2C(=O)N(C(c12)c1ccc(Cl)cc1)c1cc(C)c2nnc(C)n2c1)C1CCOCC1
Show InChI InChI=1S/C27H29ClN6O2/c1-15(2)33-24-22(29-26(33)19-9-11-36-12-10-19)27(35)34(23(24)18-5-7-20(28)8-6-18)21-13-16(3)25-31-30-17(4)32(25)14-21/h5-8,13-15,19,23H,9-12H2,1-4H3
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Novartis AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)


BindingDB Entry DOI: 10.7270/Q2TM7DFQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM380632
PNG
(6-(4-chlorophenyl)-5-(3,8-dimethyl-[1,2,4]triazolo...)
Show SMILES CC(C)n1c(C)nc2C(=O)N(C(c12)c1ccc(Cl)cc1)c1cc(C)c2nnc(C)n2n1
Show InChI InChI=1S/C22H22ClN7O/c1-11(2)28-13(4)24-18-20(28)19(15-6-8-16(23)9-7-15)29(22(18)31)17-10-12(3)21-26-25-14(5)30(21)27-17/h6-11,19H,1-5H3
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Novartis AG

US Patent


Assay Description
All assays were performed in 384 well microtiter plates. Each assay plate contained 8-point serial dilutions for 40 test compounds, plus 16 high- and...


US Patent US9890166 (2018)


BindingDB Entry DOI: 10.7270/Q2TM7DFQ
More data for this
Ligand-Target Pair
Bromodomain-containing protein 2


(Homo sapiens (Human))
BDBM313795
PNG
(US10167292, Example 39)
Show SMILES C[C@@H](NC(=O)c1ccc2-c3c(C)nnn3CCN(c3ccc(Cl)cc3)c2c1)c1ccccc1
Show InChI InChI=1S/C26H24ClN5O/c1-17(19-6-4-3-5-7-19)28-26(33)20-8-13-23-24(16-20)31(22-11-9-21(27)10-12-22)14-15-32-25(23)18(2)29-30-32/h3-13,16-17H,14-15H2,1-2H3,(H,28,33)/t17-/m1/s1
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Walter and Eliza Hall Institute of Medical Research

Curated by ChEMBL


Assay Description
Inhibition of human His-tagged Brd2 bromodomain 2 expressed in Escherichia coli BL21 (DE3) preincubated for 30 mins followed by addition of biotinyla...


ACS Med Chem Lett 8: 1298-1303 (2017)


Article DOI: 10.1021/acsmedchemlett.7b00389
BindingDB Entry DOI: 10.7270/Q2JQ13K2
More data for this
Ligand-Target Pair
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