Compile Data Set for Download or QSAR

Found 112 hits of ic50 for UniProtKB: A0A024RBT3   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM141416 (US10668051, Compound Example 67 | US8921364, 67) Show SMILES Fc1cnccc1C(=O)Nc1ccc(cc1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C19H14F4N4O/c20-15-10-24-8-7-14(15)18(28)25-12-3-5-13(6-4-12)27-16(11-1-2-11)9-17(26-27)19(21,22)23/h3-11H,1-2H2,(H,25,28)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	20.4	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020)
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM141426 (US10668051, Compound Example 84 | US8921364, 84) Show SMILES Cc1oncc1C(=O)Nc1ccc(c(F)c1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C18H14F4N4O2/c1-9-12(8-23-28-9)17(27)24-11-4-5-14(13(19)6-11)26-15(10-2-3-10)7-16(25-26)18(20,21)22/h4-8,10H,2-3H2,1H3,(H,24,27)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	20.8	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020)
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM141438 (US10668051, Compound Example 104 | US8921364, 104) Show SMILES Cc1ccccc1C(=O)Nc1ccc(nc1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C20H17F3N4O/c1-12-4-2-3-5-15(12)19(28)25-14-8-9-18(24-11-14)27-16(13-6-7-13)10-17(26-27)20(21,22)23/h2-5,8-11,13H,6-7H2,1H3,(H,25,28)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020)
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM50204536 (CHEMBL3984105) Show SMILES COc1ccc(OC)c(c1)-c1ccc(cc1)N(C)C(=O)c1ccncc1F Show InChI InChI=1S/C21H19FN2O3/c1-24(21(25)17-10-11-23-13-19(17)22)15-6-4-14(5-7-15)18-12-16(26-2)8-9-20(18)27-3/h4-13H,1-3H3	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
The University of Queensland Curated by ChEMBL					Assay Description Inhibition of Orai1 (unknown origin) by patch clamp assay				Bioorg Med Chem 25: 440-449 (2017) Article DOI: 10.1016/j.bmc.2016.11.007 BindingDB Entry DOI: 10.7270/Q2HT2R9F
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM141428 (US10668051, Compound Example 87 | US8921364, 87) Show SMILES Fc1cccc(C(=O)Nc2ccc(c(F)c2)-n2nc(cc2C2CC2)C(F)(F)F)c1F Show InChI InChI=1S/C20H13F6N3O/c21-13-3-1-2-12(18(13)23)19(30)27-11-6-7-15(14(22)8-11)29-16(10-4-5-10)9-17(28-29)20(24,25)26/h1-3,6-10H,4-5H2,(H,27,30)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	32.6	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020)
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM141421 (US10668051, Compound Example 78 | US8921364, 78) Show SMILES Cc1ncsc1NC(=O)c1ccc(cc1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C18H15F3N4OS/c1-10-17(27-9-22-10)23-16(26)12-4-6-13(7-5-12)25-14(11-2-3-11)8-15(24-25)18(19,20)21/h4-9,11H,2-3H2,1H3,(H,23,26)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	34.1	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020)
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM141424 (US10668051, Compound Example 82 | US8921364, 82) Show SMILES Cc1nnsc1C(=O)Nc1ccc(c(F)c1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C17H13F4N5OS/c1-8-15(28-25-23-8)16(27)22-10-4-5-12(11(18)6-10)26-13(9-2-3-9)7-14(24-26)17(19,20)21/h4-7,9H,2-3H2,1H3,(H,22,27)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	35.7	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020)
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM141396 (US10668051, Compound Example 7 | US8921364, 7) Show SMILES Cc1ccccc1C(=O)Nc1ccc(cc1)-n1nc(cc1C1CC1)C1CC1 Show InChI InChI=1S/C23H23N3O/c1-15-4-2-3-5-20(15)23(27)24-18-10-12-19(13-11-18)26-22(17-8-9-17)14-21(25-26)16-6-7-16/h2-5,10-14,16-17H,6-9H2,1H3,(H,24,27)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	36.4	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020)
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM141444 (US10668051, Compound Example 114 | US8921364, 114) Show SMILES Fc1cnccc1C(=O)Nc1ccc(nc1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C18H13F4N5O/c19-13-9-23-6-5-12(13)17(28)25-11-3-4-16(24-8-11)27-14(10-1-2-10)7-15(26-27)18(20,21)22/h3-10H,1-2H2,(H,25,28)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	37.6	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020)
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM152937 (US8993612, 20) Show SMILES FC(F)(F)c1cc(C2CC2)n(n1)-c1ccc(NC(=O)Cn2nnc3ccccc23)cc1 Show InChI InChI=1S/C21H17F3N6O/c22-21(23,24)19-11-18(13-5-6-13)30(27-19)15-9-7-14(8-10-15)25-20(31)12-29-17-4-2-1-3-16(17)26-28-29/h1-4,7-11,13H,5-6,12H2,(H,25,31)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	39.2	n/a	n/a	n/a	n/a	n/a	37
Rhizen Pharmaceuticals SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...				US Patent US8993612 (2015) BindingDB Entry DOI: 10.7270/Q2CN72NK
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM141442 (US10668051, Compound Example 111 | US8921364, 111) Show SMILES FC(F)(F)c1cc(C2CC2)n(n1)-c1ccc(NC(=O)c2cccnc2)cn1 Show InChI InChI=1S/C18H14F3N5O/c19-18(20,21)15-8-14(11-3-4-11)26(25-15)16-6-5-13(10-23-16)24-17(27)12-2-1-7-22-9-12/h1-2,5-11H,3-4H2,(H,24,27)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	47.2	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020)
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM141419 (US10668051, Compound Example 74 | US8921364, 74) Show SMILES Cc1ncsc1CNc1ccc(cc1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C18H17F3N4S/c1-11-16(26-10-23-11)9-22-13-4-6-14(7-5-13)25-15(12-2-3-12)8-17(24-25)18(19,20)21/h4-8,10,12,22H,2-3,9H2,1H3	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	48	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020)
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM141418 (US10668051, Compound Example 72 | US8921364, 72) Show SMILES FC(F)(F)c1cc(C2CC2)n(n1)-c1ccc(NC(=O)Cc2cccnc2)cc1 Show InChI InChI=1S/C20H17F3N4O/c21-20(22,23)18-11-17(14-3-4-14)27(26-18)16-7-5-15(6-8-16)25-19(28)10-13-2-1-9-24-12-13/h1-2,5-9,11-12,14H,3-4,10H2,(H,25,28)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	48.2	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020)
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM141425 (US10668051, Compound Example 83 | US8921364, 83) Show SMILES Cc1ncsc1C(=O)Nc1ccc(c(F)c1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C18H14F4N4OS/c1-9-16(28-8-23-9)17(27)24-11-4-5-13(12(19)6-11)26-14(10-2-3-10)7-15(25-26)18(20,21)22/h4-8,10H,2-3H2,1H3,(H,24,27)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	48.2	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020)
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM141441 (US10668051, Compound Example 108 | US8921364, 108) Show SMILES Fc1cccc(F)c1C(=O)Nc1ccc(nc1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C19H13F5N4O/c20-12-2-1-3-13(21)17(12)18(29)26-11-6-7-16(25-9-11)28-14(10-4-5-10)8-15(27-28)19(22,23)24/h1-3,6-10H,4-5H2,(H,26,29)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	50.6	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020)
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM152932 (US8993612, 6) Show SMILES O=C(Cn1nnc2ccccc12)Nc1ccc(cc1)-n1nc(cc1C1CC1)C1CC1 Show InChI InChI=1S/C23H22N6O/c30-23(14-28-21-4-2-1-3-19(21)25-27-28)24-17-9-11-18(12-10-17)29-22(16-7-8-16)13-20(26-29)15-5-6-15/h1-4,9-13,15-16H,5-8,14H2,(H,24,30)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	51.3	n/a	n/a	n/a	n/a	n/a	37
Rhizen Pharmaceuticals SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...				US Patent US8993612 (2015) BindingDB Entry DOI: 10.7270/Q2CN72NK
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM141448 (US10668051, Compound Example 126 | US8921364, 126) Show SMILES Cc1ncsc1C(=O)Nc1ccc(cc1)-n1nc(cc1C(F)F)C(F)(F)F Show InChI InChI=1S/C16H11F5N4OS/c1-8-13(27-7-22-8)15(26)23-9-2-4-10(5-3-9)25-11(14(17)18)6-12(24-25)16(19,20)21/h2-7,14H,1H3,(H,23,26)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	52.6	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020)
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM152936 (US8993612, 18) Show SMILES FC(F)(F)c1cc(C2CC2)n(n1)-c1ccc(NC(=O)c2ccc3nccnc3c2)cc1 Show InChI InChI=1S/C22H16F3N5O/c23-22(24,25)20-12-19(13-1-2-13)30(29-20)16-6-4-15(5-7-16)28-21(31)14-3-8-17-18(11-14)27-10-9-26-17/h3-13H,1-2H2,(H,28,31)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	53.4	n/a	n/a	n/a	n/a	n/a	37
Rhizen Pharmaceuticals SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...				US Patent US8993612 (2015) BindingDB Entry DOI: 10.7270/Q2CN72NK
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM141439 (US10668051, Compound Example 106 | US8921364, 106) Show SMILES Fc1ccccc1C(=O)Nc1ccc(nc1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C19H14F4N4O/c20-14-4-2-1-3-13(14)18(28)25-12-7-8-17(24-10-12)27-15(11-5-6-11)9-16(26-27)19(21,22)23/h1-4,7-11H,5-6H2,(H,25,28)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020)
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM141402 (US10668051, Compound Example 28 | US8921364, 28) Show SMILES Cc1nnsc1C(=O)Nc1ccc(c(F)c1)-n1nc(cc1C1CC1)C1CC1 Show InChI InChI=1S/C19H18FN5OS/c1-10-18(27-24-22-10)19(26)21-13-6-7-16(14(20)8-13)25-17(12-4-5-12)9-15(23-25)11-2-3-11/h6-9,11-12H,2-5H2,1H3,(H,21,26)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	60.3	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020)
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM141393 (US10668051, Compound Example 1 | US8921364, 1) Show SMILES Cc1nnsc1C(=O)Nc1ccc(cc1)-n1nc(cc1C1CC1)C1CC1 Show InChI InChI=1S/C19H19N5OS/c1-11-18(26-23-21-11)19(25)20-14-6-8-15(9-7-14)24-17(13-4-5-13)10-16(22-24)12-2-3-12/h6-10,12-13H,2-5H2,1H3,(H,20,25)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	62.4	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020)
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM141443 (US10668051, Compound Example 113 | US8921364, 113) Show SMILES FC(F)(F)c1cc(C2CC2)n(n1)-c1ccc(NC(=O)c2ccncc2)cn1 Show InChI InChI=1S/C18H14F3N5O/c19-18(20,21)15-9-14(11-1-2-11)26(25-15)16-4-3-13(10-23-16)24-17(27)12-5-7-22-8-6-12/h3-11H,1-2H2,(H,24,27)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	62.6	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020)
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM141412 (US10668051, Compound Example 56 | US8921364, 56) Show SMILES Cc1oncc1C(=O)Nc1ccc(cc1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C18H15F3N4O2/c1-10-14(9-22-27-10)17(26)23-12-4-6-13(7-5-12)25-15(11-2-3-11)8-16(24-25)18(19,20)21/h4-9,11H,2-3H2,1H3,(H,23,26)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	63.2	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020)
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM141409 (US10668051, Compound Example 49 | US8921364, 49) Show SMILES FC(F)(F)c1cc(C2CC2)n(n1)-c1ccc(NC(=O)c2c(Cl)cncc2Cl)cc1 Show InChI InChI=1S/C19H13Cl2F3N4O/c20-13-8-25-9-14(21)17(13)18(29)26-11-3-5-12(6-4-11)28-15(10-1-2-10)7-16(27-28)19(22,23)24/h3-10H,1-2H2,(H,26,29)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	65.5	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020)
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM141440 (US10668051, Compound Example 107 | US8921364, 107) Show SMILES Fc1cccc(C(=O)Nc2ccc(nc2)-n2nc(cc2C2CC2)C(F)(F)F)c1F Show InChI InChI=1S/C19H13F5N4O/c20-13-3-1-2-12(17(13)21)18(29)26-11-6-7-16(25-9-11)28-14(10-4-5-10)8-15(27-28)19(22,23)24/h1-3,6-10H,4-5H2,(H,26,29)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	70.3	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020)
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM141411 (US10668051, Compound Example 53 | US8921364, 53) Show SMILES Cc1ncsc1C(=O)Nc1ccc(cc1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C18H15F3N4OS/c1-10-16(27-9-22-10)17(26)23-12-4-6-13(7-5-12)25-14(11-2-3-11)8-15(24-25)18(19,20)21/h4-9,11H,2-3H2,1H3,(H,23,26)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	72	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020)
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM141445 (US10668051, Compound Example 122 | US8921364, 122) Show SMILES Fc1cccc(F)c1NC(=O)c1ccc(nc1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C19H13F5N4O/c20-12-2-1-3-13(21)17(12)26-18(29)11-6-7-16(25-9-11)28-14(10-4-5-10)8-15(27-28)19(22,23)24/h1-3,6-10H,4-5H2,(H,26,29)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	72.1	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020)
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM141434 (US10668051, Compound Example 93 | US8921364, 93) Show SMILES Cc1ncncc1C(=O)Nc1ccc(c(F)c1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C19H15F4N5O/c1-10-13(8-24-9-25-10)18(29)26-12-4-5-15(14(20)6-12)28-16(11-2-3-11)7-17(27-28)19(21,22)23/h4-9,11H,2-3H2,1H3,(H,26,29)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	81.2	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020)
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM152935 (US8993612, 17) Show SMILES FC(F)(F)c1cc(C2CC2)n(n1)-c1ccc(NC(=O)c2ccc3ncccc3c2)cc1 Show InChI InChI=1S/C23H17F3N4O.ClH/c24-23(25,26)21-13-20(14-3-4-14)30(29-21)18-8-6-17(7-9-18)28-22(31)16-5-10-19-15(12-16)2-1-11-27-19;/h1-2,5-14H,3-4H2,(H,28,31);1H	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	86.1	n/a	n/a	n/a	n/a	n/a	37
Rhizen Pharmaceuticals SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...				US Patent US8993612 (2015) BindingDB Entry DOI: 10.7270/Q2CN72NK
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM141429 (US10668051, Compound Example 88 | US8921364, 88) Show SMILES Fc1cccc(F)c1C(=O)Nc1ccc(c(F)c1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C20H13F6N3O/c21-12-2-1-3-13(22)18(12)19(30)27-11-6-7-15(14(23)8-11)29-16(10-4-5-10)9-17(28-29)20(24,25)26/h1-3,6-10H,4-5H2,(H,27,30)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	98.6	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020)
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM141436 (US10668051, Compound Example 100 | US8921364, 100) Show SMILES Fc1cccc(F)c1NC(=O)c1ccc(c(F)c1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C20H13F6N3O/c21-12-2-1-3-13(22)18(12)27-19(30)11-6-7-15(14(23)8-11)29-16(10-4-5-10)9-17(28-29)20(24,25)26/h1-3,6-10H,4-5H2,(H,27,30)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	99.7	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020)
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM50064638 (CHEMBL3403744) Show SMILES Cn1nc(cc1-c1cnc2[nH]c(cc2c1)-c1c(F)cccc1Cl)C(F)(F)F Show InChI InChI=1S/C18H11ClF4N4/c1-27-14(7-15(26-27)18(21,22)23)10-5-9-6-13(25-17(9)24-8-10)16-11(19)3-2-4-12(16)20/h2-8H,1H3,(H,24,25)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	<100	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of human Orai1/STIM1 expressed in HEK293 cells assessed as inhibition of channel-mediated calcium current by electrophysiology assay in pr...				Bioorg Med Chem Lett 25: 1217-22 (2015) Article DOI: 10.1016/j.bmcl.2015.01.063 BindingDB Entry DOI: 10.7270/Q2KW5HQC
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM50064639 (CHEMBL3403751) Show SMILES COc1cc(C)c(cn1)-c1cnc2[nH]c(cc2c1)-c1c(F)cccc1Cl Show InChI InChI=1S/C20H15ClFN3O/c1-11-6-18(26-2)23-10-14(11)13-7-12-8-17(25-20(12)24-9-13)19-15(21)4-3-5-16(19)22/h3-10H,1-2H3,(H,24,25)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	104	n/a	n/a	n/a	n/a	n/a	n/a
Rhône-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of human Orai1/STIM1 expressed in HEK293 cells assessed as inhibition of channel-mediated calcium current by electrophysiology assay in pr...				Bioorg Med Chem Lett 25: 1217-22 (2015) Article DOI: 10.1016/j.bmcl.2015.01.063 BindingDB Entry DOI: 10.7270/Q2KW5HQC
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM141414 (US10668051, Compound Example 60 | US8921364, 60) Show SMILES Cc1ccccc1C(=O)Nc1ccc(cc1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C21H18F3N3O/c1-13-4-2-3-5-17(13)20(28)25-15-8-10-16(11-9-15)27-18(14-6-7-14)12-19(26-27)21(22,23)24/h2-5,8-12,14H,6-7H2,1H3,(H,25,28)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020)
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM141413 (US10668051, Compound Example 57 | US8921364, 57) Show SMILES Cc1noc(C)c1C(=O)Nc1ccc(cc1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C19H17F3N4O2/c1-10-17(11(2)28-25-10)18(27)23-13-5-7-14(8-6-13)26-15(12-3-4-12)9-16(24-26)19(20,21)22/h5-9,12H,3-4H2,1-2H3,(H,23,27)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	124	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020)
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM141422 (US10668051, Compound Example 79 | US8921364, 79) Show SMILES Fc1cccc(F)c1NC(=O)c1ccc(cc1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C20H14F5N3O/c21-14-2-1-3-15(22)18(14)26-19(29)12-6-8-13(9-7-12)28-16(11-4-5-11)10-17(27-28)20(23,24)25/h1-3,6-11H,4-5H2,(H,26,29)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	124	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020)
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM141399 (US10668051, Compound Example 17 | US8921364, 17) Show SMILES Clc1cncc(Cl)c1C(=O)Nc1ccc(cc1)-n1nc(cc1C1CC1)C1CC1 Show InChI InChI=1S/C21H18Cl2N4O/c22-16-10-24-11-17(23)20(16)21(28)25-14-5-7-15(8-6-14)27-19(13-3-4-13)9-18(26-27)12-1-2-12/h5-13H,1-4H2,(H,25,28)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020)
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM152938 (US8993612, 21) Show SMILES FC(F)(F)c1cc(C2CC2)n(n1)-c1ccc(NC(=O)Cn2nc3ccccc3n2)cc1 Show InChI InChI=1S/C21H17F3N6O/c22-21(23,24)19-11-18(13-5-6-13)30(28-19)15-9-7-14(8-10-15)25-20(31)12-29-26-16-3-1-2-4-17(16)27-29/h1-4,7-11,13H,5-6,12H2,(H,25,31)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	139	n/a	n/a	n/a	n/a	n/a	37
Rhizen Pharmaceuticals SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...				US Patent US8993612 (2015) BindingDB Entry DOI: 10.7270/Q2CN72NK
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM141397 (US10668051, Compound Example 15 | US8921364, 15) Show SMILES O=C(Nc1ccc(cc1)-n1nc(cc1C1CC1)C1CC1)c1ccncc1 Show InChI InChI=1S/C21H20N4O/c26-21(16-9-11-22-12-10-16)23-17-5-7-18(8-6-17)25-20(15-3-4-15)13-19(24-25)14-1-2-14/h5-15H,1-4H2,(H,23,26)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	141	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020)
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM141403 (US10668051, Compound Example 33 | US8921364, 33) Show SMILES Fc1cccc(F)c1C(=O)Nc1ccc(c(F)c1)-n1nc(cc1C1CC1)C1CC1 Show InChI InChI=1S/C22H18F3N3O/c23-15-2-1-3-16(24)21(15)22(29)26-14-8-9-19(17(25)10-14)28-20(13-6-7-13)11-18(27-28)12-4-5-12/h1-3,8-13H,4-7H2,(H,26,29)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	145	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020)
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM152933 (US8993612, 10) Show SMILES O=C(Cc1ccc2ncccc2c1)Nc1ccc(cc1)-n1nc(cc1C1CC1)C1CC1 Show InChI InChI=1S/C26H24N4O/c31-26(15-17-3-12-23-20(14-17)2-1-13-27-23)28-21-8-10-22(11-9-21)30-25(19-6-7-19)16-24(29-30)18-4-5-18/h1-3,8-14,16,18-19H,4-7,15H2,(H,28,31)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	147	n/a	n/a	n/a	n/a	n/a	37
Rhizen Pharmaceuticals SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...				US Patent US8993612 (2015) BindingDB Entry DOI: 10.7270/Q2CN72NK
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM141427 (US10668051, Compound Example 86 | US8921364, 86) Show SMILES Cc1ccccc1C(=O)Nc1ccc(c(F)c1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C21H17F4N3O/c1-12-4-2-3-5-15(12)20(29)26-14-8-9-17(16(22)10-14)28-18(13-6-7-13)11-19(27-28)21(23,24)25/h2-5,8-11,13H,6-7H2,1H3,(H,26,29)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	147	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020)
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM141437 (US10668051, Compound Example 101 | US8921364, 101) Show SMILES Cc1nnsc1C(=O)Nc1ccc(nc1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C16H13F3N6OS/c1-8-14(27-24-22-8)15(26)21-10-4-5-13(20-7-10)25-11(9-2-3-9)6-12(23-25)16(17,18)19/h4-7,9H,2-3H2,1H3,(H,21,26)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020)
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM141433 (US10668051, Compound Example 92 | US8921364, 92) Show SMILES Fc1cc(NC(=O)c2c(Cl)cncc2Cl)ccc1-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C19H12Cl2F4N4O/c20-11-7-26-8-12(21)17(11)18(30)27-10-3-4-14(13(22)5-10)29-15(9-1-2-9)6-16(28-29)19(23,24)25/h3-9H,1-2H2,(H,27,30)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	159	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020)
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM141432 (US10668051, Compound Example 91 | US8921364, 91) Show SMILES Fc1cnccc1C(=O)Nc1ccc(c(F)c1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C19H13F5N4O/c20-13-7-11(26-18(29)12-5-6-25-9-14(12)21)3-4-15(13)28-16(10-1-2-10)8-17(27-28)19(22,23)24/h3-10H,1-2H2,(H,26,29)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	159	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020)
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM152939 (US8993612, 30) Show SMILES Fc1cc(NC(=O)Cn2nnc3ccccc23)ccc1-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C21H16F4N6O/c22-14-9-13(26-20(32)11-30-17-4-2-1-3-15(17)27-29-30)7-8-16(14)31-18(12-5-6-12)10-19(28-31)21(23,24)25/h1-4,7-10,12H,5-6,11H2,(H,26,32)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	161	n/a	n/a	n/a	n/a	n/a	37
Rhizen Pharmaceuticals SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...				US Patent US8993612 (2015) BindingDB Entry DOI: 10.7270/Q2CN72NK
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM141406 (US10668051, Compound Example 37 | US8921364, 37) Show SMILES Cc1nnsc1C(=O)Nc1ccc(c(F)c1)-n1nc(C2CC2)c(Cl)c1C1CC1 Show InChI InChI=1S/C19H17ClFN5OS/c1-9-18(28-25-23-9)19(27)22-12-6-7-14(13(21)8-12)26-17(11-4-5-11)15(20)16(24-26)10-2-3-10/h6-8,10-11H,2-5H2,1H3,(H,22,27)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	181	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020)
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM152930 (US8993612, 2) Show SMILES O=C(Nc1ccc(cc1)-n1nc(cc1C1CC1)C1CC1)c1ccc2nn[nH]c2c1 Show InChI InChI=1S/C22H20N6O/c29-22(15-5-10-18-20(11-15)25-27-24-18)23-16-6-8-17(9-7-16)28-21(14-3-4-14)12-19(26-28)13-1-2-13/h5-14H,1-4H2,(H,23,29)(H,24,25,27)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	183	n/a	n/a	n/a	n/a	n/a	37
Rhizen Pharmaceuticals SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...				US Patent US8993612 (2015) BindingDB Entry DOI: 10.7270/Q2CN72NK
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM141410 (US10668051, Compound Example 52 | US8921364, 52) Show SMILES Cc1nnsc1C(=O)Nc1ccc(cc1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C17H14F3N5OS/c1-9-15(27-24-22-9)16(26)21-11-4-6-12(7-5-11)25-13(10-2-3-10)8-14(23-25)17(18,19)20/h4-8,10H,2-3H2,1H3,(H,21,26)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	184	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020)
					More data for this Ligand-Target Pair
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM141404 (US10668051, Compound Example 35 | US8921364, 35) Show SMILES Fc1cc(NC(=O)c2ccncc2)ccc1-n1nc(cc1C1CC1)C1CC1 Show InChI InChI=1S/C21H19FN4O/c22-17-11-16(24-21(27)15-7-9-23-10-8-15)5-6-19(17)26-20(14-3-4-14)12-18(25-26)13-1-2-13/h5-14H,1-4H2,(H,24,27)	Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	185	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020)
					More data for this Ligand-Target Pair

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