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Compile Data Set for Download or QSAR

Found 5 hits of kd for UniProtKB: Q13639   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM50092543
PNG
(4-Amino-5-chloro-2-methoxy-benzoic acid 2-(4-pyrim...)
Show SMILES COc1cc(N)c(Cl)cc1C(=O)OCCN1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C18H22ClN5O3/c1-26-16-12-15(20)14(19)11-13(16)17(25)27-10-9-23-5-7-24(8-6-23)18-21-3-2-4-22-18/h2-4,11-12H,5-10,20H2,1H3
UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 0.700n/an/an/an/an/a



INSERM

Curated by ChEMBL


Assay Description
,Antagonism of stimulation of 5-hydroxytryptamine receptor on the L-type calcium current (I Ca) in isolated human atrial myocytes


J Med Chem 43: 3761-9 (2000)


Article DOI: 10.1021/jm0009538
BindingDB Entry DOI: 10.7270/Q2CC0ZXH
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 4 (5-HT4)


(Homo sapiens (Human))
BDBM29525
PNG
(3H-GR113808 | CHEMBL518682 | GR 113808 | [3H] GR 1...)
Show SMILES Cn1cc(C(=O)OCC2CCN(CCNS(C)(=O)=O)CC2)c2ccccc12
Show InChI InChI=1S/C19H27N3O4S/c1-21-13-17(16-5-3-4-6-18(16)21)19(23)26-14-15-7-10-22(11-8-15)12-9-20-27(2,24)25/h3-6,13,15,20H,7-12,14H2,1-2H3
UniProtKB/SwissProt

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CHEBI
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/an/a 15.8n/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity to human 5HT4 receptor expressed in HEK293 cells by saturation binding method


J Nat Prod 69: 1421-4 (2006)


Article DOI: 10.1021/np0601760
BindingDB Entry DOI: 10.7270/Q2H9950V
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50224305
PNG
(CHEMBL285355)
Show SMILES CSc1cccc2[nH]cc(CCN(C)C)c12
Show InChI InChI=1S/C13H18N2S/c1-15(2)8-7-10-9-14-11-5-4-6-12(16-3)13(10)11/h4-6,9,14H,7-8H2,1-3H3
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 0.00000800n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Ability to displace [3H]5-HT binding to 5-hydroxytryptamine receptor site using 1 uM LSD as masking ligand, activity is expressed as Kd.


J Med Chem 25: 908-13 (1982)


Article DOI: 10.1021/jm00350a005
BindingDB Entry DOI: 10.7270/Q2H70J1R
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50224302
PNG
(CHEMBL31783)
Show SMILES CSc1ccc2[nH]cc(CCN(C)C)c2c1
Show InChI InChI=1S/C13H18N2S/c1-15(2)7-6-10-9-14-13-5-4-11(16-3)8-12(10)13/h4-5,8-9,14H,6-7H2,1-3H3
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 0n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Ability to displace [3H]5-HT binding to 5-hydroxytryptamine receptor using 1 uM LSD as masking ligand, activity is expressed as Kd.


J Med Chem 25: 908-13 (1982)


Article DOI: 10.1021/jm00350a005
BindingDB Entry DOI: 10.7270/Q2H70J1R
More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM50224303
PNG
(CHEMBL283686)
Show SMILES CN(C)CCc1c[nH]c2cc3OCOc3cc12
Show InChI InChI=1S/C13H16N2O2/c1-15(2)4-3-9-7-14-11-6-13-12(5-10(9)11)16-8-17-13/h5-7,14H,3-4,8H2,1-2H3
PDB

UniProtKB/SwissProt

GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/a 0.00000800n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Ability to displace [3H]5-HT binding to 5-hydroxytryptamine receptor site using 1 uM LSD as masking ligand, activity is expressed as Kd.


J Med Chem 25: 908-13 (1982)


Article DOI: 10.1021/jm00350a005
BindingDB Entry DOI: 10.7270/Q2H70J1R
More data for this
Ligand-Target Pair