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Compile Data Set for Download or QSAR

Found 25 hits of ec50 for UniProtKB: P06213   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Insulin receptor


(Homo sapiens (Human))
BDBM313069
PNG
(1-(6-chloroquinazolin-4-yl)-N3-(4-(2-(pyrrolidin-1...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1ncnc2ccc(Cl)cc12
Show InChI InChI=1S/C22H23ClN8O/c23-15-3-8-19-18(13-15)20(26-14-25-19)31-21(24)28-22(29-31)27-16-4-6-17(7-5-16)32-12-11-30-9-1-2-10-30/h3-8,13-14H,1-2,9-12H2,(H3,24,27,28,29)
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n/an/an/an/a 14n/an/an/an/a



Rigel Pharmaceuticals, Inc

Curated by ChEMBL


Assay Description
Inhibition of insulin stimulated INSR phosphorylation in human HeLa cells preincubated for 1 hr followed by insulin addition measured after 5 mins by...


Bioorg Med Chem Lett 27: 3766-3771 (2017)

More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (Human))
BDBM313084
PNG
(1-(6-fluoroquinazolin-4-yl)-N3-(4-(2-(pyrrolidin-1...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1ncnc2ccc(F)cc12
Show InChI InChI=1S/C22H23FN8O/c23-15-3-8-19-18(13-15)20(26-14-25-19)31-21(24)28-22(29-31)27-16-4-6-17(7-5-16)32-12-11-30-9-1-2-10-30/h3-8,13-14H,1-2,9-12H2,(H3,24,27,28,29)
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n/an/an/an/a 126n/an/an/an/a



Rigel Pharmaceuticals, Inc

Curated by ChEMBL


Assay Description
Inhibition of insulin stimulated INSR phosphorylation in human HeLa cells preincubated for 1 hr followed by insulin addition measured after 5 mins by...


Bioorg Med Chem Lett 27: 3766-3771 (2017)

More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (Human))
BDBM313027
PNG
(N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetra...)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1nc(Cl)nc2ccccc12
Show InChI InChI=1S/C22H23ClN8O/c23-20-26-18-6-2-1-5-17(18)19(27-20)31-21(24)28-22(29-31)25-15-7-9-16(10-8-15)32-14-13-30-11-3-4-12-30/h1-2,5-10H,3-4,11-14H2,(H3,24,25,28,29)
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n/an/an/an/a 241n/an/an/an/a



Rigel Pharmaceuticals, Inc

Curated by ChEMBL


Assay Description
Inhibition of insulin stimulated INSR phosphorylation in human HeLa cells preincubated for 1 hr followed by insulin addition measured after 5 mins by...


Bioorg Med Chem Lett 27: 3766-3771 (2017)

More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (Human))
BDBM50269393
PNG
(CHEMBL4078564)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1ncnc2c3ccccc3sc12
Show InChI InChI=1S/C24H24N8OS/c25-23-29-24(28-16-7-9-17(10-8-16)33-14-13-31-11-3-4-12-31)30-32(23)22-21-20(26-15-27-22)18-5-1-2-6-19(18)34-21/h1-2,5-10,15H,3-4,11-14H2,(H3,25,28,29,30)
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n/an/an/an/a 300n/an/an/an/a



Rigel Pharmaceuticals, Inc

Curated by ChEMBL


Assay Description
Inhibition of insulin stimulated INSR phosphorylation in human HeLa cells preincubated for 1 hr followed by insulin addition measured after 5 mins by...


Bioorg Med Chem Lett 27: 3766-3771 (2017)

More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (Human))
BDBM50092143
PNG
(2,5-Dihydroxy-3-(1H-indol-3-yl)-6-phenyl-[1,4]benz...)
Show SMILES O=C1C(c2c[nH]c3ccccc23)C(=O)C(=O)C(C1=O)c1ccccc1
Show InChI InChI=1S/C20H13NO4/c22-17-15(11-6-2-1-3-7-11)18(23)20(25)16(19(17)24)13-10-21-14-9-5-4-8-12(13)14/h1-10,15-16,21H
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n/an/an/an/a 300n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Activation of human insulin receptor tyrosine kinase (IRTK)


J Med Chem 43: 3487-94 (2000)


Article DOI: 10.1021/jm000285q
BindingDB Entry DOI: 10.7270/Q2NV9HHG
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (Human))
BDBM50092150
PNG
(2,5-Dihydroxy-3-(1-methyl-1H-indol-3-yl)-6-phenyl-...)
Show SMILES Cn1cc(C2C(=O)C(=O)C(C(=O)C2=O)c2ccccc2)c2ccccc12
Show InChI InChI=1S/C21H15NO4/c1-22-11-14(13-9-5-6-10-15(13)22)17-20(25)18(23)16(19(24)21(17)26)12-7-3-2-4-8-12/h2-11,16-17H,1H3
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n/an/an/an/a 300n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Activation of human insulin receptor tyrosine kinase (IRTK)


J Med Chem 43: 3487-94 (2000)


Article DOI: 10.1021/jm000285q
BindingDB Entry DOI: 10.7270/Q2NV9HHG
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (Human))
BDBM313086
PNG
(1-(2-methylquinazolin-4-yl)-N3-(4-(2-(pyrrolidin-1...)
Show SMILES Cc1nc(-n2nc(Nc3ccc(OCCN4CCCC4)cc3)nc2N)c2ccccc2n1
Show InChI InChI=1S/C23H26N8O/c1-16-25-20-7-3-2-6-19(20)21(26-16)31-22(24)28-23(29-31)27-17-8-10-18(11-9-17)32-15-14-30-12-4-5-13-30/h2-3,6-11H,4-5,12-15H2,1H3,(H3,24,27,28,29)
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n/an/an/an/a 320n/an/an/an/a



Rigel Pharmaceuticals, Inc

Curated by ChEMBL


Assay Description
Inhibition of insulin stimulated INSR phosphorylation in human HeLa cells preincubated for 1 hr followed by insulin addition measured after 5 mins by...


Bioorg Med Chem Lett 27: 3766-3771 (2017)

More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (Human))
BDBM313081
PNG
(1-(2-chloro-7-methylthieno[3,2-d]pyrimidin-4-yl)-N...)
Show SMILES Cc1csc2c(nc(Cl)nc12)-n1nc(Nc2ccc(OCCN3CCCC3)cc2)nc1N
Show InChI InChI=1S/C21H23ClN8OS/c1-13-12-32-17-16(13)25-19(22)26-18(17)30-20(23)27-21(28-30)24-14-4-6-15(7-5-14)31-11-10-29-8-2-3-9-29/h4-7,12H,2-3,8-11H2,1H3,(H3,23,24,27,28)
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n/an/an/an/a 582n/an/an/an/a



Rigel Pharmaceuticals, Inc

Curated by ChEMBL


Assay Description
Inhibition of insulin stimulated INSR phosphorylation in human HeLa cells preincubated for 1 hr followed by insulin addition measured after 5 mins by...


Bioorg Med Chem Lett 27: 3766-3771 (2017)

More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (Human))
BDBM50092148
PNG
(2-Benzo[b]thiophen-3-yl-3,6-dihydroxy-5-phenyl-[1,...)
Show SMILES O=C1C(c2csc3ccccc23)C(=O)C(=O)C(C1=O)c1ccccc1
Show InChI InChI=1S/C20H12O4S/c21-17-15(11-6-2-1-3-7-11)18(22)20(24)16(19(17)23)13-10-25-14-9-5-4-8-12(13)14/h1-10,15-16H
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n/an/an/an/a 1.00E+3n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Activation of human insulin receptor tyrosine kinase (IRTK)


J Med Chem 43: 3487-94 (2000)


Article DOI: 10.1021/jm000285q
BindingDB Entry DOI: 10.7270/Q2NV9HHG
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (Human))
BDBM50242742
PNG
(5-CHLORO-N-[2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL...)
Show SMILES COc1cc(ccc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1)N1CCC(CC1)N1CCN(C)CC1
Show InChI InChI=1S/C30H40ClN7O3S/c1-21(2)42(39,40)28-8-6-5-7-26(28)33-29-24(31)20-32-30(35-29)34-25-10-9-23(19-27(25)41-4)37-13-11-22(12-14-37)38-17-15-36(3)16-18-38/h5-10,19-22H,11-18H2,1-4H3,(H2,32,33,34,35)
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n/an/an/an/a 1.00E+3n/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of InsR by cellular assay


Proc Natl Acad Sci USA 104: 19936-41 (2007)


Article DOI: 10.1073/pnas.0707498104
BindingDB Entry DOI: 10.7270/Q24X58QS
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (Human))
BDBM50269375
PNG
(CHEMBL4086420)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)cc2)nn1-c1ncnc2CCCc12
Show InChI InChI=1S/C21H26N8O/c22-20-26-21(27-29(20)19-17-4-3-5-18(17)23-14-24-19)25-15-6-8-16(9-7-15)30-13-12-28-10-1-2-11-28/h6-9,14H,1-5,10-13H2,(H3,22,25,26,27)
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n/an/an/an/a 1.01E+3n/an/an/an/a



Rigel Pharmaceuticals, Inc

Curated by ChEMBL


Assay Description
Inhibition of insulin stimulated INSR phosphorylation in human HeLa cells preincubated for 1 hr followed by insulin addition measured after 5 mins by...


Bioorg Med Chem Lett 27: 3766-3771 (2017)

More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (Human))
BDBM313137
PNG
(1-(6,7-dimethoxyquinazolin-4-yl)-N3-(4-(1-methylpi...)
Show SMILES COc1cc2ncnc(-n3nc(Nc4ccc(cc4)C4CCN(C)CC4)nc3N)c2cc1OC
Show InChI InChI=1S/C24H28N8O2/c1-31-10-8-16(9-11-31)15-4-6-17(7-5-15)28-24-29-23(25)32(30-24)22-18-12-20(33-2)21(34-3)13-19(18)26-14-27-22/h4-7,12-14,16H,8-11H2,1-3H3,(H3,25,28,29,30)
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n/an/an/an/a 1.32E+3n/an/an/an/a



Rigel Pharmaceuticals, Inc

Curated by ChEMBL


Assay Description
Inhibition of insulin stimulated INSR phosphorylation in human HeLa cells preincubated for 1 hr followed by insulin addition measured after 5 mins by...


Bioorg Med Chem Lett 27: 3766-3771 (2017)

More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (Human))
BDBM50092146
PNG
(2-Benzofuran-3-yl-3,6-dihydroxy-5-phenyl-[1,4]benz...)
Show SMILES O=C1C(c2coc3ccccc23)C(=O)C(=O)C(C1=O)c1ccccc1
Show InChI InChI=1S/C20H12O5/c21-17-15(11-6-2-1-3-7-11)18(22)20(24)16(19(17)23)13-10-25-14-9-5-4-8-12(13)14/h1-10,15-16H
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n/an/an/an/a 1.50E+3n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Activation of human insulin receptor tyrosine kinase (IRTK)


J Med Chem 43: 3487-94 (2000)


Article DOI: 10.1021/jm000285q
BindingDB Entry DOI: 10.7270/Q2NV9HHG
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (Human))
BDBM313124
PNG
(1-(6,7-dimethoxyquinazolin-4-yl)-N3-(4-(1-methylpi...)
Show SMILES COc1cc2ncnc(-n3nc(Nc4ccc(OC5CCCN(C)C5)cc4)nc3N)c2cc1OC
Show InChI InChI=1/C24H28N8O3/c1-31-10-4-5-17(13-31)35-16-8-6-15(7-9-16)28-24-29-23(25)32(30-24)22-18-11-20(33-2)21(34-3)12-19(18)26-14-27-22/h6-9,11-12,14,17H,4-5,10,13H2,1-3H3,(H3,25,28,29,30)
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n/an/an/an/a 1.80E+3n/an/an/an/a



Rigel Pharmaceuticals, Inc

Curated by ChEMBL


Assay Description
Inhibition of insulin stimulated INSR phosphorylation in human HeLa cells preincubated for 1 hr followed by insulin addition measured after 5 mins by...


Bioorg Med Chem Lett 27: 3766-3771 (2017)

More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (Human))
BDBM50242740
PNG
(CHEMBL459850 | N-(3-(7-Amino-1-methyl-2-oxo-1,2-di...)
Show SMILES CN1C(=O)N(Cc2cnc(N)nc12)c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C
Show InChI InChI=1S/C22H19F3N6O2/c1-12-6-7-16(28-19(32)13-4-3-5-15(8-13)22(23,24)25)9-17(12)31-11-14-10-27-20(26)29-18(14)30(2)21(31)33/h3-10H,11H2,1-2H3,(H,28,32)(H2,26,27,29)
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n/an/an/an/a>2.00E+3n/an/an/an/a



Harvard Medical School

Curated by ChEMBL


Assay Description
Inhibition of InsR by cellular assay


Proc Natl Acad Sci USA 104: 19936-41 (2007)


Article DOI: 10.1073/pnas.0707498104
BindingDB Entry DOI: 10.7270/Q24X58QS
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (Human))
BDBM50269384
PNG
(CHEMBL4095081)
Show SMILES Nc1nc(Nc2ccc(OCCN3CCCC3)c(F)c2)nn1C(=O)c1ccc(cc1)N1CCOCC1
Show InChI InChI=1S/C25H30FN7O3/c26-21-17-19(5-8-22(21)36-16-11-31-9-1-2-10-31)28-25-29-24(27)33(30-25)23(34)18-3-6-20(7-4-18)32-12-14-35-15-13-32/h3-8,17H,1-2,9-16H2,(H3,27,28,29,30)
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n/an/an/an/a 2.75E+3n/an/an/an/a



Rigel Pharmaceuticals, Inc

Curated by ChEMBL


Assay Description
Inhibition of insulin stimulated INSR phosphorylation in human HeLa cells preincubated for 1 hr followed by insulin addition measured after 5 mins by...


Bioorg Med Chem Lett 27: 3766-3771 (2017)

More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (Human))
BDBM313080
PNG
(N3-(3-chloro-4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)-...)
Show SMILES COc1cc2ncnc(-n3nc(Nc4ccc(OCCN5CCCC5)c(Cl)c4)nc3N)c2cc1OC
Show InChI InChI=1S/C24H27ClN8O3/c1-34-20-12-16-18(13-21(20)35-2)27-14-28-22(16)33-23(26)30-24(31-33)29-15-5-6-19(17(25)11-15)36-10-9-32-7-3-4-8-32/h5-6,11-14H,3-4,7-10H2,1-2H3,(H3,26,29,30,31)
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n/an/an/an/a 4.17E+3n/an/an/an/a



Rigel Pharmaceuticals, Inc

Curated by ChEMBL


Assay Description
Inhibition of insulin stimulated INSR phosphorylation in human HeLa cells preincubated for 1 hr followed by insulin addition measured after 5 mins by...


Bioorg Med Chem Lett 27: 3766-3771 (2017)

More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (Human))
BDBM50269389
PNG
(CHEMBL4069483)
Show SMILES COc1cc2ncnc(-n3nc(Nc4ccc(cc4)N4CCN(C)CC4)nc3N)c2cc1OC
Show InChI InChI=1S/C23H27N9O2/c1-30-8-10-31(11-9-30)16-6-4-15(5-7-16)27-23-28-22(24)32(29-23)21-17-12-19(33-2)20(34-3)13-18(17)25-14-26-21/h4-7,12-14H,8-11H2,1-3H3,(H3,24,27,28,29)
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n/an/an/an/a 4.58E+3n/an/an/an/a



Rigel Pharmaceuticals, Inc

Curated by ChEMBL


Assay Description
Inhibition of insulin stimulated INSR phosphorylation in human HeLa cells preincubated for 1 hr followed by insulin addition measured after 5 mins by...


Bioorg Med Chem Lett 27: 3766-3771 (2017)

More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (Human))
BDBM313140
PNG
(1-(6,7-dimethoxyquinazolin-4-yl)-N3-(4-((S)-3-(dim...)
Show SMILES COc1cc2ncnc(-n3nc(Nc4ccc(cc4)N4CC[C@@H](C4)N(C)C)nc3N)c2cc1OC
Show InChI InChI=1S/C24H29N9O2/c1-31(2)17-9-10-32(13-17)16-7-5-15(6-8-16)28-24-29-23(25)33(30-24)22-18-11-20(34-3)21(35-4)12-19(18)26-14-27-22/h5-8,11-12,14,17H,9-10,13H2,1-4H3,(H3,25,28,29,30)/t17-/m0/s1
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n/an/an/an/a 4.76E+3n/an/an/an/a



Rigel Pharmaceuticals, Inc

Curated by ChEMBL


Assay Description
Inhibition of insulin stimulated INSR phosphorylation in human HeLa cells preincubated for 1 hr followed by insulin addition measured after 5 mins by...


Bioorg Med Chem Lett 27: 3766-3771 (2017)

More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (Human))
BDBM50092149
PNG
(2-[2-(1,1-Dimethyl-allyl)-1H-indol-3-yl]-3,6-dihyd...)
Show SMILES CC(C)=CCc1cccc2c(c[nH]c12)C1C(=O)C(=O)C(c2c([nH]c3ccccc23)C(C)(C)C=C)C(=O)C1=O
Show InChI InChI=1S/C32H30N2O4/c1-6-32(4,5)31-23(20-11-7-8-13-22(20)34-31)25-29(37)27(35)24(28(36)30(25)38)21-16-33-26-18(15-14-17(2)3)10-9-12-19(21)26/h6-14,16,24-25,33-34H,1,15H2,2-5H3
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n/an/an/an/a 5.00E+3n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Activation of human insulin receptor tyrosine kinase (IRTK)


J Med Chem 43: 3487-94 (2000)


Article DOI: 10.1021/jm000285q
BindingDB Entry DOI: 10.7270/Q2NV9HHG
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (Human))
BDBM50269390
PNG
(CHEMBL4080190)
Show SMILES COc1cc2ncnc(-n3nc(Nc4ccc(N5CCN(CC5)C5CCCCC5)c(F)c4)nc3N)c2cc1OC
Show InChI InChI=1S/C28H34FN9O2/c1-39-24-15-20-22(16-25(24)40-2)31-17-32-26(20)38-27(30)34-28(35-38)33-18-8-9-23(21(29)14-18)37-12-10-36(11-13-37)19-6-4-3-5-7-19/h8-9,14-17,19H,3-7,10-13H2,1-2H3,(H3,30,33,34,35)
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n/an/an/an/a 5.03E+3n/an/an/an/a



Rigel Pharmaceuticals, Inc

Curated by ChEMBL


Assay Description
Inhibition of insulin stimulated INSR phosphorylation in human HeLa cells preincubated for 1 hr followed by insulin addition measured after 5 mins by...


Bioorg Med Chem Lett 27: 3766-3771 (2017)

More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (Human))
BDBM50092147
PNG
(2,5-Dihydroxy-3-naphthalen-1-yl-6-phenyl-[1,4]benz...)
Show SMILES O=C1C(C(=O)C(=O)C(C1=O)c1cccc2ccccc12)c1ccccc1
Show InChI InChI=1S/C22H14O4/c23-19-17(14-8-2-1-3-9-14)20(24)22(26)18(21(19)25)16-12-6-10-13-7-4-5-11-15(13)16/h1-12,17-18H
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n/an/an/an/a 6.00E+3n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Activation of human insulin receptor tyrosine kinase (IRTK)


J Med Chem 43: 3487-94 (2000)


Article DOI: 10.1021/jm000285q
BindingDB Entry DOI: 10.7270/Q2NV9HHG
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (Human))
BDBM50092144
PNG
(2,5-Dihydroxy-3-(1H-indol-3-yl)-6-(7-methyl-1H-ind...)
Show SMILES Cc1cccc2c(c[nH]c12)C1C(=O)C(=O)C(c2c[nH]c3ccccc23)C(=O)C1=O
Show InChI InChI=1S/C23H16N2O4/c1-11-5-4-7-13-15(10-25-19(11)13)18-22(28)20(26)17(21(27)23(18)29)14-9-24-16-8-3-2-6-12(14)16/h2-10,17-18,24-25H,1H3
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n/an/an/an/a 7.00E+3n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Activation of human insulin receptor tyrosine kinase (IRTK)


J Med Chem 43: 3487-94 (2000)


Article DOI: 10.1021/jm000285q
BindingDB Entry DOI: 10.7270/Q2NV9HHG
More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (Human))
BDBM50269391
PNG
(CHEMBL4059790)
Show SMILES COc1cc2ncnc(-n3nc(Nc4ccc(N5CCN(CC5)C5CC6CCC5C6)c(Cl)c4)nc3N)c2cc1OC
Show InChI InChI=1S/C29H34ClN9O2/c1-40-25-14-20-22(15-26(25)41-2)32-16-33-27(20)39-28(31)35-29(36-39)34-19-5-6-23(21(30)13-19)37-7-9-38(10-8-37)24-12-17-3-4-18(24)11-17/h5-6,13-18,24H,3-4,7-12H2,1-2H3,(H3,31,34,35,36)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Rigel Pharmaceuticals, Inc

Curated by ChEMBL


Assay Description
Inhibition of insulin stimulated INSR phosphorylation in human HeLa cells preincubated for 1 hr followed by insulin addition measured after 5 mins by...


Bioorg Med Chem Lett 27: 3766-3771 (2017)

More data for this
Ligand-Target Pair
Insulin receptor


(Homo sapiens (Human))
BDBM50092145
PNG
(2,5-Dihydroxy-3-naphthalen-2-yl-6-phenyl-[1,4]benz...)
Show SMILES O=C1C(C(=O)C(=O)C(C1=O)c1ccc2ccccc2c1)c1ccccc1
Show InChI InChI=1S/C22H14O4/c23-19-17(14-7-2-1-3-8-14)20(24)22(26)18(21(19)25)16-11-10-13-6-4-5-9-15(13)12-16/h1-12,17-18H
PDB
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PubMed
n/an/an/an/a 3.00E+4n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Activation of human insulin receptor tyrosine kinase (IRTK)


J Med Chem 43: 3487-94 (2000)


Article DOI: 10.1021/jm000285q
BindingDB Entry DOI: 10.7270/Q2NV9HHG
More data for this
Ligand-Target Pair