Compile Data Set for Download or QSAR
maximum 50k data
Found 1053 of ic50 for UniProtKB: Q05769
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM50272095(4-(3-(4-methoxyphenyl)-1H-indol-2-yl)benzenesulfon...)
Affinity DataIC50:  0.00603nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM50272131(3-(4-fluorophenyl)-2-(4-(methylsulfonyl)phenyl)-1H...)
Affinity DataIC50:  0.0200nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM50272096(3-(4-methoxyphenyl)-2-(4-(methylsulfonyl)phenyl)-1...)
Affinity DataIC50:  0.0200nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM50272129(4-(5-methyl-3-phenyl-1H-indol-2-yl)benzenesulfonam...)
Affinity DataIC50:  0.0200nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM50272125(4-(3-p-tolyl-1H-indol-2-yl)benzenesulfonamide | CH...)
Affinity DataIC50:  0.0692nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM50272126(2-(4-(methylsulfonyl)phenyl)-3-p-tolyl-1H-indole |...)
Affinity DataIC50:  0.0891nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM50272105(4-(3-phenyl-1H-indol-2-yl)benzenesulfonamide | CHE...)
Affinity DataIC50:  0.0891nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM50272110(4-(5-chloro-3-phenyl-1H-indol-2-yl)benzenesulfonam...)
Affinity DataIC50:  0.141nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM50272097(3-(3,4-dimethylphenyl)-2-(4-(methylsulfonyl)phenyl...)
Affinity DataIC50:  0.170nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM50272128(CHEMBL500943 | N-(4-(3-phenyl-1H-indol-2-yl)phenyl...)
Affinity DataIC50:  0.178nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM50272130(5-methyl-2-(4-(methylsulfonyl)phenyl)-3-phenyl-1H-...)
Affinity DataIC50:  0.282nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM50272111(5-chloro-2-(4-(methylsulfonyl)phenyl)-3-phenyl-1H-...)
Affinity DataIC50:  0.363nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM50272124(3-(4-bromophenyl)-2-(4-(methylsulfonyl)phenyl)-1H-...)
Affinity DataIC50:  0.372nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50:  0.510nMAssay Description:Inhibition of LPS-induced COX2 activity in C57BL/6J mouse peritoneal macrophages by RIAMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM50272090(4-(5-chloro-3-(4-chlorophenyl)-1H-indol-2-yl)benze...)
Affinity DataIC50:  0.537nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM50094551(3,5-Bis-(4-fluoro-phenyl)-4-aza-tricyclo[5.2.2.0*2...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition against prostaglandin G/H synthase 2 from mouse resident macrophagesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM50094551(3,5-Bis-(4-fluoro-phenyl)-4-aza-tricyclo[5.2.2.0*2...)
Affinity DataIC50:  0.601nMAssay Description:Inhibition of mouse macrophage COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM50272106(2-(4-(methylsulfonyl)phenyl)-3-phenyl-1H-indole | ...)
Affinity DataIC50:  0.603nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM50094542(1,3-Diphenyl-2,4,5,6-tetrahydro-cyclopenta[c]pyrro...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition against prostaglandin G/H synthase 2 from mouse resident macrophagesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM50094542(1,3-Diphenyl-2,4,5,6-tetrahydro-cyclopenta[c]pyrro...)
Affinity DataIC50:  0.701nMAssay Description:Inhibition of mouse macrophage COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM50272092(5-chloro-3-(3-chlorophenyl)-2-(4-(methylsulfonyl)p...)
Affinity DataIC50:  0.794nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM50094539(3,5-Bis-(4-fluoro-phenyl)-4-aza-tricyclo[5.2.1.0*2...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition against prostaglandin G/H synthase 2 from mouse resident macrophagesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM50094539(3,5-Bis-(4-fluoro-phenyl)-4-aza-tricyclo[5.2.1.0*2...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of mouse macrophage COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM50566911(CHEMBL4868446)
Affinity DataIC50:  1.30nMAssay Description:In vivo inhibition of COX2 in po dosed C57BL/6J mouse model of spontaneous GI-tract tumor Apc-min assessed as chemopreventive effect by measuring red...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM50272113(5-bromo-2-(4-(methylsulfonyl)phenyl)-3-phenyl-1H-i...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM50272127(4-(3-(3,4-dimethylphenyl)-1H-indol-2-yl)benzenesul...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM50094540(1,3-diphenyl-4,5,6,7-tetrahydro-2H-isoindole | CHE...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition against prostaglandin G/H synthase 2 from mouse resident macrophagesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM50094540(1,3-diphenyl-4,5,6,7-tetrahydro-2H-isoindole | CHE...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of mouse macrophage COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM50094546(3,5-Diphenyl-4-aza-tricyclo[5.2.2.0*2,6*]undeca-2,...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of mouse macrophage COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM50094546(3,5-Diphenyl-4-aza-tricyclo[5.2.2.0*2,6*]undeca-2,...)
Affinity DataIC50:  1.60nMAssay Description:Inhibition against prostaglandin G/H synthase 2 from mouse resident macrophagesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM50094563(1,3-Di-p-tolyl-4,5,6,7-tetrahydro-2H-isoindole | 1...)
Affinity DataIC50:  1.67nMAssay Description:Inhibition against prostaglandin G/H synthase 2 from mouse resident macrophagesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM50094534(1,3-Bis-(4-fluoro-phenyl)-4,5,6,7-tetrahydro-2H-is...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition against prostaglandin G/H synthase 2 from mouse resident macrophagesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM50094534(1,3-Bis-(4-fluoro-phenyl)-4,5,6,7-tetrahydro-2H-is...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of mouse macrophage COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM50094532(1,3-Diphenyl-4,5,6,7-tetrahydro-isoindol-2-ylamine...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of mouse macrophage COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM50094532(1,3-Diphenyl-4,5,6,7-tetrahydro-isoindol-2-ylamine...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition against prostaglandin G/H synthase 2 from mouse resident macrophagesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM50566912(CHEMBL4859571)
Affinity DataIC50:  1.90nMAssay Description:In vivo inhibition of COX2 in po dosed C57BL/6J mouse model of spontaneous GI-tract tumor Apc-min assessed as chemopreventive effect by measuring red...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM50272109(4-(5-fluoro-3-phenyl-1H-indol-2-yl)benzenesulfonam...)
Affinity DataIC50:  2nMAssay Description:Inhibition of COX2 in Mus musculus (mouse) peritoneal macrophageMore data for this Ligand-Target Pair
In DepthDetails Article
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM50029593(CHEMBL7162 | N-(2-(cyclohexyloxy)-4-nitrophenyl)me...)
Affinity DataIC50: <2nMAssay Description:Inhibitory activity against murine Prostaglandin G/H synthase 2.More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM50173289(2-Fluoro-4-(5-methyl-3-phenyl-isoxazol-4-yl)-benze...)
Affinity DataIC50:  2nMAssay Description:Tested for prostaglandin E2 production as a function of COX-2 inhibition using endotoxin-treated murine RAW 264.7 macrophagesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM50173288(4-(5-Fluoromethyl-3-phenyl-isoxazol-4-yl)-benzenes...)
Affinity DataIC50:  2nMAssay Description:Tested for prostaglandin E2 production as a function of COX-2 inhibition using endotoxin-treated murine RAW 264.7 macrophagesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM50173290(4-[5-(2-Fluoro-ethyl)-3-phenyl-isoxazol-4-yl]-benz...)
Affinity DataIC50:  2nMAssay Description:Tested for prostaglandin E2 production as a function of COX-2 inhibition using endotoxin-treated murine RAW 264.7 macrophagesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM50173287(4-[3-(4-Fluoro-phenyl)-5-methyl-isoxazol-4-yl]-ben...)
Affinity DataIC50:  2nMAssay Description:Tested for prostaglandin E2 production as a function of COX-2 inhibition using endotoxin-treated murine RAW 264.7 macrophagesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM50492037(CHEMBL2391055)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of COX2 in mouse J774 cells assessed as inhibition of LPS-induced PGE2 production by radioimmunoassayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM50361590(CHEMBL1939677)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of COX-2-mediated PGE2 production in LPS-stimulated mouse J774 cells after 24 hrs by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM50094558(3,5-Diphenyl-4-aza-tricyclo[5.2.1.0*2,6*]deca-2,5-...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of mouse macrophage COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM50094558(3,5-Diphenyl-4-aza-tricyclo[5.2.1.0*2,6*]deca-2,5-...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition against prostaglandin G/H synthase 2 from mouse resident macrophagesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM50094548(1,3-Bis-(4-fluoro-phenyl)-2,4,5,6-tetrahydro-cyclo...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition against prostaglandin G/H synthase 2 from mouse resident macrophagesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM50094548(1,3-Bis-(4-fluoro-phenyl)-2,4,5,6-tetrahydro-cyclo...)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of mouse macrophage COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM50589579(CHEMBL5185981)
Affinity DataIC50:  3nMAssay Description:Inhibition of COX2 in LPS-stimulated mouse J774 cells assessed as inhibition of PGE2 production and measured after 24 hrs by enzyme immuno-assay (EIA...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))TBA
LigandPNGBDBM50094528(5,6-Dimethyl-1,3-diphenyl-4,5,6,7-tetrahydro-2H-is...)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of mouse macrophage COX2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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