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Compile Data Set for Download or QSAR

Found 602 hits of ec50 data for polymerid = 8949   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM281732
PNG
(US10023528, Example 5 | US10023528, Example 6)
Show SMILES C[C@H]([C@H](C(=O)Nc1cc(ccc1Cl)C(C)(CC(O)=O)C1CCC1)c1ccc(Cl)cc1)C(F)(F)F
Show InChI InChI=1S/C25H26Cl2F3NO3/c1-14(25(28,29)30)22(15-6-9-18(26)10-7-15)23(34)31-20-12-17(8-11-19(20)27)24(2,13-21(32)33)16-4-3-5-16/h6-12,14,16,22H,3-5,13H2,1-2H3,(H,31,34)(H,32,33)/t14-,22+,24?/m1/s1
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n/an/an/an/a 5.20n/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
To carry out the assay, 29 μl of enzyme solution [0-10 nM soluble guanylate cyclase (prepared according to Hönicka et al, J. Mol. Med. 77, 14-23...


US Patent US10023528 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM281737
PNG
(US10023528, Example 14)
Show SMILES CC(C)C(CC(O)=O)c1ccc(Cl)c(NC(=O)[C@@H]([C@@H](C)C(F)(F)F)c2ccc(cc2)C(C)(C)C)c1
Show InChI InChI=1S/C27H33ClF3NO3/c1-15(2)20(14-23(33)34)18-9-12-21(28)22(13-18)32-25(35)24(16(3)27(29,30)31)17-7-10-19(11-8-17)26(4,5)6/h7-13,15-16,20,24H,14H2,1-6H3,(H,32,35)(H,33,34)/t16-,20?,24+/m1/s1
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n/an/an/an/a 8.40n/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
To carry out the assay, 29 μl of enzyme solution [0-10 nM soluble guanylate cyclase (prepared according to Hönicka et al, J. Mol. Med. 77, 14-23...


US Patent US10023528 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM281734
PNG
(US10023528, Example 10)
Show SMILES CC(C)C(CC(O)=O)c1ccc(Cl)c(NC(=O)[C@@H]([C@@H](C)C(F)(F)F)c2ccc(cc2)C(C)C)c1
Show InChI InChI=1S/C26H31ClF3NO3/c1-14(2)17-6-8-18(9-7-17)24(16(5)26(28,29)30)25(34)31-22-12-19(10-11-21(22)27)20(15(3)4)13-23(32)33/h6-12,14-16,20,24H,13H2,1-5H3,(H,31,34)(H,32,33)/t16-,20?,24+/m1/s1
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n/an/an/an/a 10n/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
To carry out the assay, 29 μl of enzyme solution [0-10 nM soluble guanylate cyclase (prepared according to Hönicka et al, J. Mol. Med. 77, 14-23...


US Patent US10023528 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM281742
PNG
((+)-3-(4-Chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4...)
Show SMILES C[C@H]([C@H](C(=O)Nc1cc(ccc1Cl)C(CC(O)=O)C1CCC1)c1ccc(Cl)cc1)C(F)(F)F
Show InChI InChI=1S/C24H24Cl2F3NO3/c1-13(24(27,28)29)22(15-5-8-17(25)9-6-15)23(33)30-20-11-16(7-10-19(20)26)18(12-21(31)32)14-3-2-4-14/h5-11,13-14,18,22H,2-4,12H2,1H3,(H,30,33)(H,31,32)/t13-,18?,22+/m1/s1
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n/an/an/an/a 11n/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
To carry out the assay, 29 μl of enzyme solution [0-10 nM soluble guanylate cyclase (prepared according to Hönicka et al, J. Mol. Med. 77, 14-23...


US Patent US10023528 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM281743
PNG
(US10023528, Example 35)
Show SMILES C[C@H]([C@H](C(=O)Nc1cc(ccc1Cl)C(CC1CC1)CC(O)=O)c1ccc(Cl)cc1)C(F)(F)F
Show InChI InChI=1S/C24H24Cl2F3NO3/c1-13(24(27,28)29)22(15-4-7-18(25)8-5-15)23(33)30-20-11-16(6-9-19(20)26)17(12-21(31)32)10-14-2-3-14/h4-9,11,13-14,17,22H,2-3,10,12H2,1H3,(H,30,33)(H,31,32)/t13-,17?,22+/m1/s1
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n/an/an/an/a 11n/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
To carry out the assay, 29 μl of enzyme solution [0-10 nM soluble guanylate cyclase (prepared according to Hönicka et al, J. Mol. Med. 77, 14-23...


US Patent US10023528 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM281736
PNG
(US10023528, Example 13)
Show SMILES CC(C)C(CC(O)=O)c1ccc(Cl)c(NC(=O)[C@@H]([C@@H](C)C(F)(F)F)c2ccc(cc2)C2CC2(F)F)c1
Show InChI InChI=1S/C26H27ClF5NO3/c1-13(2)18(11-22(34)35)17-8-9-20(27)21(10-17)33-24(36)23(14(3)26(30,31)32)16-6-4-15(5-7-16)19-12-25(19,28)29/h4-10,13-14,18-19,23H,11-12H2,1-3H3,(H,33,36)(H,34,35)/t14-,18?,19?,23+/m1/s1
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n/an/an/an/a 14n/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
To carry out the assay, 29 μl of enzyme solution [0-10 nM soluble guanylate cyclase (prepared according to Hönicka et al, J. Mol. Med. 77, 14-23...


US Patent US10023528 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM281735
PNG
(US10023528, Example 12)
Show SMILES CC(C)C(CC(O)=O)c1ccc(Cl)c(NC(=O)C(C(C)C(F)(F)F)c2ccc(CC(F)(F)F)cc2)c1
Show InChI InChI=1S/C25H26ClF6NO3/c1-13(2)18(11-21(34)35)17-8-9-19(26)20(10-17)33-23(36)22(14(3)25(30,31)32)16-6-4-15(5-7-16)12-24(27,28)29/h4-10,13-14,18,22H,11-12H2,1-3H3,(H,33,36)(H,34,35)
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n/an/an/an/a 17n/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
To carry out the assay, 29 μl of enzyme solution [0-10 nM soluble guanylate cyclase (prepared according to Hönicka et al, J. Mol. Med. 77, 14-23...


US Patent US10023528 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM281728
PNG
((+)-3-(4-Chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4...)
Show SMILES CC(C)C(CC(O)=O)c1ccc(Cl)c(NC(=O)[C@@H]([C@@H](C)C(F)(F)F)c2ccc(Cl)cc2)c1
Show InChI InChI=1S/C23H24Cl2F3NO3/c1-12(2)17(11-20(30)31)15-6-9-18(25)19(10-15)29-22(32)21(13(3)23(26,27)28)14-4-7-16(24)8-5-14/h4-10,12-13,17,21H,11H2,1-3H3,(H,29,32)(H,30,31)/t13-,17?,21+/m1/s1
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n/an/an/an/a 22n/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
To carry out the assay, 29 μl of enzyme solution [0-10 nM soluble guanylate cyclase (prepared according to Hönicka et al, J. Mol. Med. 77, 14-23...


US Patent US10023528 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM281730
PNG
(US10023528, Example 3 | US10023528, Example 4)
Show SMILES CC(C)C(C)(CC(O)=O)c1ccc(Cl)c(NC(=O)[C@@H]([C@@H](C)C(F)(F)F)c2ccc(Cl)cc2)c1
Show InChI InChI=1S/C24H26Cl2F3NO3/c1-13(2)23(4,12-20(31)32)16-7-10-18(26)19(11-16)30-22(33)21(14(3)24(27,28)29)15-5-8-17(25)9-6-15/h5-11,13-14,21H,12H2,1-4H3,(H,30,33)(H,31,32)/t14-,21+,23?/m1/s1
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n/an/an/an/a 37n/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
To carry out the assay, 29 μl of enzyme solution [0-10 nM soluble guanylate cyclase (prepared according to Hönicka et al, J. Mol. Med. 77, 14-23...


US Patent US10023528 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM281732
PNG
(US10023528, Example 5 | US10023528, Example 6)
Show SMILES C[C@H]([C@H](C(=O)Nc1cc(ccc1Cl)C(C)(CC(O)=O)C1CCC1)c1ccc(Cl)cc1)C(F)(F)F
Show InChI InChI=1S/C25H26Cl2F3NO3/c1-14(25(28,29)30)22(15-6-9-18(26)10-7-15)23(34)31-20-12-17(8-11-19(20)27)24(2,13-21(32)33)16-4-3-5-16/h6-12,14,16,22H,3-5,13H2,1-2H3,(H,31,34)(H,32,33)/t14-,22+,24?/m1/s1
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n/an/an/an/a 56n/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
To carry out the assay, 29 μl of enzyme solution [0-10 nM soluble guanylate cyclase (prepared according to Hönicka et al, J. Mol. Med. 77, 14-23...


US Patent US10023528 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM281738
PNG
((+)-3-(4-Chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4...)
Show SMILES C[C@H]([C@H](C(=O)Nc1cc(ccc1Cl)C(CC(O)=O)C1CC1)c1ccc(Cl)cc1)C(F)(F)F
Show InChI InChI=1S/C23H22Cl2F3NO3/c1-12(23(26,27)28)21(14-4-7-16(24)8-5-14)22(32)29-19-10-15(6-9-18(19)25)17(11-20(30)31)13-2-3-13/h4-10,12-13,17,21H,2-3,11H2,1H3,(H,29,32)(H,30,31)/t12-,17?,21+/m1/s1
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n/an/an/an/a 68n/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
To carry out the assay, 29 μl of enzyme solution [0-10 nM soluble guanylate cyclase (prepared according to Hönicka et al, J. Mol. Med. 77, 14-23...


US Patent US10023528 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM281740
PNG
(US10023528, Example 27)
Show SMILES C[C@H]([C@H](C(=O)Nc1cc(ccc1Cl)C(CC(O)=O)C1(F)CC1)c1ccc(Cl)cc1)C(F)(F)F
Show InChI InChI=1S/C23H21Cl2F4NO3/c1-12(23(27,28)29)20(13-2-5-15(24)6-3-13)21(33)30-18-10-14(4-7-17(18)25)16(11-19(31)32)22(26)8-9-22/h2-7,10,12,16,20H,8-9,11H2,1H3,(H,30,33)(H,31,32)/t12-,16?,20+/m1/s1
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n/an/an/an/a 68n/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
To carry out the assay, 29 μl of enzyme solution [0-10 nM soluble guanylate cyclase (prepared according to Hönicka et al, J. Mol. Med. 77, 14-23...


US Patent US10023528 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM281729
PNG
((+)-3-(4-Chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4...)
Show SMILES CC(C)C(CC(O)=O)c1ccc(Cl)c(NC(=O)[C@@H]([C@@H](C)C(F)(F)F)c2ccc(Cl)cc2)c1
Show InChI InChI=1S/C23H24Cl2F3NO3/c1-12(2)17(11-20(30)31)15-6-9-18(25)19(10-15)29-22(32)21(13(3)23(26,27)28)14-4-7-16(24)8-5-14/h4-10,12-13,17,21H,11H2,1-3H3,(H,29,32)(H,30,31)/t13-,17?,21+/m1/s1
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n/an/an/an/a 89n/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT

US Patent


Assay Description
To carry out the assay, 29 μl of enzyme solution [0-10 nM soluble guanylate cyclase (prepared according to Hönicka et al, J. Mol. Med. 77, 14-23...


US Patent US10023528 (2018)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM321537
PNG
(US10183021, Compound I-129)
Show SMILES OC(=O)C1(CNc2nc(ncc2F)-c2cc(-c3ccon3)n(Cc3ccccc3F)n2)CCCC1
Show InChI InChI=1S/C24H22F2N6O3/c25-16-6-2-1-5-15(16)13-32-20(18-7-10-35-31-18)11-19(30-32)22-27-12-17(26)21(29-22)28-14-24(23(33)34)8-3-4-9-24/h1-2,5-7,10-12H,3-4,8-9,13-14H2,(H,33,34)(H,27,28,29)
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n/an/an/an/a<100n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10183021 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM321538
PNG
(US10183021, Compound I-371)
Show SMILES OC(=O)[C@@H]1Cc2ccccc2[C@@H]1Nc1nc(ncc1F)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C27H20F2N6O3/c28-19-8-4-2-6-16(19)14-35-23(21-9-10-38-34-21)12-22(33-35)26-30-13-20(29)25(32-26)31-24-17-7-3-1-5-15(17)11-18(24)27(36)37/h1-10,12-13,18,24H,11,14H2,(H,36,37)(H,30,31,32)/t18-,24+/m1/s1
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n/an/an/an/a<100n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10183021 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM321544
PNG
(US10183021, Compound I-329)
Show SMILES C[C@H]1CCCN([C@H]1C(O)=O)c1nc(ncc1F)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C24H22F2N6O3/c1-14-5-4-9-31(21(14)24(33)34)23-17(26)12-27-22(28-23)19-11-20(18-8-10-35-30-18)32(29-19)13-15-6-2-3-7-16(15)25/h2-3,6-8,10-12,14,21H,4-5,9,13H2,1H3,(H,33,34)/t14-,21+/m0/s1
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n/an/an/an/a<100n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10183021 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM321546
PNG
(US10183021, Compound I-330)
Show SMILES C[C@@H]1CCCN([C@@H]1C(O)=O)c1nc(ncc1F)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C24H22F2N6O3/c1-14-5-4-9-31(21(14)24(33)34)23-17(26)12-27-22(28-23)19-11-20(18-8-10-35-30-18)32(29-19)13-15-6-2-3-7-16(15)25/h2-3,6-8,10-12,14,21H,4-5,9,13H2,1H3,(H,33,34)/t14-,21+/m1/s1
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n/an/an/an/a<100n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10183021 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM321550
PNG
(US10183021, Compound I-374)
Show SMILES CN(CCS(N)(=O)=O)c1nc(ncc1F)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C20H19F2N7O3S/c1-28(7-9-33(23,30)31)20-15(22)11-24-19(25-20)17-10-18(16-6-8-32-27-16)29(26-17)12-13-4-2-3-5-14(13)21/h2-6,8,10-11H,7,9,12H2,1H3,(H2,23,30,31)
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n/an/an/an/a<100n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10183021 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM321551
PNG
(US10183021, Compound I-162)
Show SMILES C[C@H]1CCCN([C@@H]1C(O)=O)c1nc(ncc1F)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C24H22F2N6O3/c1-14-5-4-9-31(21(14)24(33)34)23-17(26)12-27-22(28-23)19-11-20(18-8-10-35-30-18)32(29-19)13-15-6-2-3-7-16(15)25/h2-3,6-8,10-12,14,21H,4-5,9,13H2,1H3,(H,33,34)/t14-,21-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10183021 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM321555
PNG
(US10183021, Compound I-452)
Show SMILES OC(=O)[C@H]1C[C@H](CCN1c1nc(ncc1F)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1)C(F)(F)F
Show InChI InChI=1S/C24H19F5N6O3/c25-15-4-2-1-3-13(15)12-35-19(17-6-8-38-33-17)10-18(32-35)21-30-11-16(26)22(31-21)34-7-5-14(24(27,28)29)9-20(34)23(36)37/h1-4,6,8,10-11,14,20H,5,7,9,12H2,(H,36,37)/t14-,20+/m0/s1
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Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10183021 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM321556
PNG
(US10183021, Compound I-305)
Show SMILES C[C@H]1CCCN([C@H]1OC=O)c1nc(ncc1F)-c1cc(-c2ccon2)n(Cc2cccc(F)c2F)n1
Show InChI InChI=1S/C24H21F3N6O3/c1-14-4-3-8-32(24(14)35-13-34)23-17(26)11-28-22(29-23)19-10-20(18-7-9-36-31-18)33(30-19)12-15-5-2-6-16(25)21(15)27/h2,5-7,9-11,13-14,24H,3-4,8,12H2,1H3/t14-,24-/m0/s1
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Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10183021 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM321557
PNG
(US10183021, Compound I-186)
Show SMILES OC(=O)C1(CCN(CC1)c1nc(ncc1F)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1)c1ccccc1
Show InChI InChI=1S/C29H24F2N6O3/c30-21-9-5-4-6-19(21)18-37-25(23-10-15-40-35-23)16-24(34-37)26-32-17-22(31)27(33-26)36-13-11-29(12-14-36,28(38)39)20-7-2-1-3-8-20/h1-10,15-17H,11-14,18H2,(H,38,39)
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Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10183021 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM321529
PNG
(US10183021, Compound I-111 | US10183021, Compound ...)
Show SMILES Fc1ccccc1Cn1nc(cc1-c1ccon1)-c1ncc(F)c(n1)N1CCc2ccccc2C1
Show InChI InChI=1S/C26H20F2N6O/c27-20-8-4-3-7-19(20)16-34-24(22-10-12-35-32-22)13-23(31-34)25-29-14-21(28)26(30-25)33-11-9-17-5-1-2-6-18(17)15-33/h1-8,10,12-14H,9,11,15-16H2
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Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10183021 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM321585
PNG
(US10183021, Compound I-409)
Show SMILES CCN(CC1(CC1)C(O)=O)c1nc(ncc1F)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C24H22F2N6O3/c1-2-31(14-24(8-9-24)23(33)34)22-17(26)12-27-21(28-22)19-11-20(18-7-10-35-30-18)32(29-19)13-15-5-3-4-6-16(15)25/h3-7,10-12H,2,8-9,13-14H2,1H3,(H,33,34)
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Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10183021 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM321586
PNG
(US10183021, Compound I-435)
Show SMILES OC[C@@H]1C[C@@H](O)CN1c1nc(ncc1F)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C22H20F2N6O3/c23-16-4-2-1-3-13(16)10-30-20(18-5-6-33-28-18)8-19(27-30)21-25-9-17(24)22(26-21)29-11-15(32)7-14(29)12-31/h1-6,8-9,14-15,31-32H,7,10-12H2/t14-,15+/m0/s1
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Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10183021 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM321587
PNG
(US10183021, Compound I-309)
Show SMILES CN([C@@H]1CC[C@@H](C1)C(O)=O)c1nc(ncc1F)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C24H22F2N6O3/c1-31(16-7-6-14(10-16)24(33)34)23-18(26)12-27-22(28-23)20-11-21(19-8-9-35-30-19)32(29-20)13-15-4-2-3-5-17(15)25/h2-5,8-9,11-12,14,16H,6-7,10,13H2,1H3,(H,33,34)/t14-,16+/m0/s1
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Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10183021 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM321588
PNG
(US10183021, Compound I-407 | US10183021, Compound ...)
Show SMILES OCCNc1nc(ncc1F)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C19H16F2N6O2/c20-13-4-2-1-3-12(13)11-27-17(15-5-8-29-26-15)9-16(25-27)19-23-10-14(21)18(24-19)22-6-7-28/h1-5,8-10,28H,6-7,11H2,(H,22,23,24)
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Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10183021 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM321589
PNG
(US10183021, Compound I-310)
Show SMILES C[C@@H]1[C@@H](CCCN1c1nc(ncc1F)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1)C(O)=O
Show InChI InChI=1S/C24H22F2N6O3/c1-14-16(24(33)34)6-4-9-31(14)23-18(26)12-27-22(28-23)20-11-21(19-8-10-35-30-19)32(29-20)13-15-5-2-3-7-17(15)25/h2-3,5,7-8,10-12,14,16H,4,6,9,13H2,1H3,(H,33,34)/t14-,16-/m1/s1
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Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10183021 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM321591
PNG
(US10183021, Compound I-406)
Show SMILES CC1(CCCN(C1)c1nc(ncc1F)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1)C(O)=O
Show InChI InChI=1S/C24H22F2N6O3/c1-24(23(33)34)8-4-9-31(14-24)22-17(26)12-27-21(28-22)19-11-20(18-7-10-35-30-18)32(29-19)13-15-5-2-3-6-16(15)25/h2-3,5-7,10-12H,4,8-9,13-14H2,1H3,(H,33,34)
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Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10183021 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM321593
PNG
(US10183021, Compound I-381)
Show SMILES Fc1ccccc1Cn1nc(cc1-c1ccon1)-c1ncc(F)c(NCCS(=O)(=O)NCC(F)(F)F)n1
Show InChI InChI=1S/C21H18F5N7O3S/c22-14-4-2-1-3-13(14)11-33-18(16-5-7-36-32-16)9-17(31-33)20-28-10-15(23)19(30-20)27-6-8-37(34,35)29-12-21(24,25)26/h1-5,7,9-10,29H,6,8,11-12H2,(H,27,28,30)
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Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10183021 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM321594
PNG
(US10183021, Compound I-337)
Show SMILES OC(CNc1nc(ncc1F)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1)C(F)(F)F
Show InChI InChI=1S/C20H15F5N6O2/c21-12-4-2-1-3-11(12)10-31-16(14-5-6-33-30-14)7-15(29-31)19-26-8-13(22)18(28-19)27-9-17(32)20(23,24)25/h1-8,17,32H,9-10H2,(H,26,27,28)
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Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10183021 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM321595
PNG
(US10183021, Compound I-382)
Show SMILES CNC(=O)C(C)(O)CN(C)c1nc(ncc1F)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C23H23F2N7O3/c1-23(34,22(33)26-2)13-31(3)21-16(25)11-27-20(28-21)18-10-19(17-8-9-35-30-17)32(29-18)12-14-6-4-5-7-15(14)24/h4-11,34H,12-13H2,1-3H3,(H,26,33)
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Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10183021 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM321596
PNG
(US10183021, Compound I-408)
Show SMILES OCCCNc1nc(ncc1F)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C20H18F2N6O2/c21-14-5-2-1-4-13(14)12-28-18(16-6-9-30-27-16)10-17(26-28)20-24-11-15(22)19(25-20)23-7-3-8-29/h1-2,4-6,9-11,29H,3,7-8,12H2,(H,23,24,25)
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Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10183021 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM321598
PNG
(US10183021, Compound I-395)
Show SMILES O[C@@H]1Cc2ccccc2[C@@H]1Nc1nc(ncc1F)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C26H20F2N6O2/c27-18-8-4-2-6-16(18)14-34-22(20-9-10-36-33-20)12-21(32-34)26-29-13-19(28)25(31-26)30-24-17-7-3-1-5-15(17)11-23(24)35/h1-10,12-13,23-24,35H,11,14H2,(H,29,30,31)/t23-,24+/m1/s1
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Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10183021 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM321599
PNG
(US10183021, Compound I-332)
Show SMILES C[C@H]1CCCN([C@@H]1C(=O)NS(=O)(=O)C1CC1)c1nc(ncc1F)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C27H27F2N7O4S/c1-16-5-4-11-35(24(16)27(37)34-41(38,39)18-8-9-18)26-20(29)14-30-25(31-26)22-13-23(21-10-12-40-33-21)36(32-22)15-17-6-2-3-7-19(17)28/h2-3,6-7,10,12-14,16,18,24H,4-5,8-9,11,15H2,1H3,(H,34,37)/t16-,24-/m0/s1
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Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10183021 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM321601
PNG
(US10183021, Compound I-344)
Show SMILES CC(C)[C@H](CN(C)c1nc(ncc1F)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1)NS(=O)(=O)C1CC1
Show InChI InChI=1S/C26H29F2N7O3S/c1-16(2)23(33-39(36,37)18-8-9-18)15-34(3)26-20(28)13-29-25(30-26)22-12-24(21-10-11-38-32-21)35(31-22)14-17-6-4-5-7-19(17)27/h4-7,10-13,16,18,23,33H,8-9,14-15H2,1-3H3/t23-/m0/s1
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Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10183021 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM321602
PNG
(US10183021, Compound I-322)
Show SMILES OC[C@@H](O)CN(CC1CC1)c1nc(ncc1F)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C24H24F2N6O3/c25-18-4-2-1-3-16(18)12-32-22(20-7-8-35-30-20)9-21(29-32)23-27-10-19(26)24(28-23)31(11-15-5-6-15)13-17(34)14-33/h1-4,7-10,15,17,33-34H,5-6,11-14H2/t17-/m0/s1
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Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10183021 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM321604
PNG
(US10183021, Compound I-351)
Show SMILES CC(C)(C)OC(=O)N1CC(O)(CNc2nc(ncc2F)-c2cc(-c3ccon3)n(Cc3ccccc3F)n2)C1
Show InChI InChI=1S/C26H27F2N7O4/c1-25(2,3)39-24(36)34-14-26(37,15-34)13-30-22-18(28)11-29-23(31-22)20-10-21(19-8-9-38-33-19)35(32-20)12-16-6-4-5-7-17(16)27/h4-11,37H,12-15H2,1-3H3,(H,29,30,31)
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Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10183021 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM321605
PNG
(US10183021, Compound I-345)
Show SMILES CN(CC1(CC1)C(O)=O)c1nc(ncc1F)-c1cc(-c2cscn2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C23H20F2N6O2S/c1-30(12-23(6-7-23)22(32)33)21-16(25)9-26-20(28-21)17-8-19(18-11-34-13-27-18)31(29-17)10-14-4-2-3-5-15(14)24/h2-5,8-9,11,13H,6-7,10,12H2,1H3,(H,32,33)
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Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10183021 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM321606
PNG
(US10183021, Compound I-352)
Show SMILES OCC(O)(CCl)CNc1nc(ncc1F)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C21H19ClF2N6O3/c22-10-21(32,12-31)11-26-19-15(24)8-25-20(27-19)17-7-18(16-5-6-33-29-16)30(28-17)9-13-3-1-2-4-14(13)23/h1-8,31-32H,9-12H2,(H,25,26,27)
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Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10183021 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM321609
PNG
(US10183021, Compound I-383)
Show SMILES CN(CC(C)(C)C(O)=O)c1nc(ncc1F)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C23H22F2N6O3/c1-23(2,22(32)33)13-30(3)21-16(25)11-26-20(27-21)18-10-19(17-8-9-34-29-17)31(28-18)12-14-6-4-5-7-15(14)24/h4-11H,12-13H2,1-3H3,(H,32,33)
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n/an/an/an/a<100n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10183021 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM321610
PNG
(US10183021, Compound I-438)
Show SMILES NC(=O)C1(O)CCN(CC1)c1nc(ncc1F)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C23H21F2N7O3/c24-15-4-2-1-3-14(15)13-32-19(17-5-10-35-30-17)11-18(29-32)20-27-12-16(25)21(28-20)31-8-6-23(34,7-9-31)22(26)33/h1-5,10-12,34H,6-9,13H2,(H2,26,33)
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n/an/an/an/a<100n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10183021 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM321613
PNG
(US10183021, Compound I-423)
Show SMILES Fc1ccccc1Cn1nc(cc1-c1ccon1)-c1ncc(F)c(n1)N1CCC(CC1)S(=O)(=O)N1CCOCC1
Show InChI InChI=1S/C26H27F2N7O4S/c27-20-4-2-1-3-18(20)17-35-24(22-7-12-39-32-22)15-23(31-35)25-29-16-21(28)26(30-25)33-8-5-19(6-9-33)40(36,37)34-10-13-38-14-11-34/h1-4,7,12,15-16,19H,5-6,8-11,13-14,17H2
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n/an/an/an/a<100n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10183021 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM321615
PNG
(US10183021, Compound I-314)
Show SMILES C[C@@H]1CN(C[C@@H]1C(O)=O)c1nc(ncc1F)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C23H20F2N6O3/c1-13-10-30(12-15(13)23(32)33)22-17(25)9-26-21(27-22)19-8-20(18-6-7-34-29-18)31(28-19)11-14-4-2-3-5-16(14)24/h2-9,13,15H,10-12H2,1H3,(H,32,33)/t13-,15+/m1/s1
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n/an/an/an/a<100n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10183021 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM321616
PNG
(US10183021, Compound I-439)
Show SMILES OCCNS(=O)(=O)CCNc1nc(ncc1F)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C21H21F2N7O4S/c22-15-4-2-1-3-14(15)13-30-19(17-5-9-34-29-17)11-18(28-30)21-25-12-16(23)20(27-21)24-7-10-35(32,33)26-6-8-31/h1-5,9,11-12,26,31H,6-8,10,13H2,(H,24,25,27)
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Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10183021 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM321617
PNG
(US10183021, Compound I-424)
Show SMILES OC(=O)[C@@H]1CN(C[C@H]1C(F)(F)F)c1nc(ncc1F)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1
Show InChI InChI=1S/C23H17F5N6O3/c24-15-4-2-1-3-12(15)9-34-19(17-5-6-37-32-17)7-18(31-34)20-29-8-16(25)21(30-20)33-10-13(22(35)36)14(11-33)23(26,27)28/h1-8,13-14H,9-11H2,(H,35,36)/t13-,14-/m1/s1
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Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10183021 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM321620
PNG
(US10183021, Compound I-396)
Show SMILES OC1(CN(C1)c1nc(ncc1F)-c1cc(-c2ccon2)n(Cc2ccccc2F)n1)C(F)(F)F
Show InChI InChI=1S/C21H15F5N6O2/c22-13-4-2-1-3-12(13)9-32-17(15-5-6-34-30-15)7-16(29-32)18-27-8-14(23)19(28-18)31-10-20(33,11-31)21(24,25)26/h1-8,33H,9-11H2
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Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10183021 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM321621
PNG
(US10183021, Compound I-387)
Show SMILES Fc1ccccc1Cn1nc(cc1-c1ccon1)-c1ncc(F)c(n1)N1CC(C1)NC(=O)C(F)(F)F
Show InChI InChI=1S/C22H16F5N7O2/c23-14-4-2-1-3-12(14)9-34-18(16-5-6-36-32-16)7-17(31-34)19-28-8-15(24)20(30-19)33-10-13(11-33)29-21(35)22(25,26)27/h1-8,13H,9-11H2,(H,29,35)
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Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10183021 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM321622
PNG
(US10183021, Compound I-397)
Show SMILES OC1(CNc2nc(ncc2F)-c2cc(-c3ccon3)n(Cc3ccccc3F)n2)CCOCC1
Show InChI InChI=1S/C23H22F2N6O3/c24-16-4-2-1-3-15(16)13-31-20(18-5-8-34-30-18)11-19(29-31)22-26-12-17(25)21(28-22)27-14-23(32)6-9-33-10-7-23/h1-5,8,11-12,32H,6-7,9-10,13-14H2,(H,26,27,28)
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n/an/an/an/a<100n/an/an/an/a



Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10183021 (2019)

More data for this
Ligand-Target Pair
Guanylate cyclase soluble subunit alpha-1


(Homo sapiens (Human))
BDBM321623
PNG
(US10183021, Compound I-425)
Show SMILES Fc1ccccc1Cn1nc(cc1-c1ccon1)-c1ncc(F)c(n1)N1CCC(CC1)S(=O)(=O)NC(=O)C1CC1
Show InChI InChI=1S/C26H25F2N7O4S/c27-19-4-2-1-3-17(19)15-35-23(21-9-12-39-32-21)13-22(31-35)24-29-14-20(28)25(30-24)34-10-7-18(8-11-34)40(37,38)33-26(36)16-5-6-16/h1-4,9,12-14,16,18H,5-8,10-11,15H2,(H,33,36)
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Ironwood Pharmaceuticals, Inc.

US Patent


Assay Description
Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....


US Patent US10183021 (2019)

More data for this
Ligand-Target Pair
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