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Found 75 of ic50 for UniProtKB: Q62645
TargetGlutamate receptor ionotropic, NMDA 2D(Rattus norvegicus (Rat))
University Of Copenhagen

LigandPNGBDBM213888(1-thioxo-1,2-dihydro-[1,2,4]triazolo[4,3-a]-quinox...)
Affinity DataIC50:  160nMpH: 7.4 T: 2°CAssay Description:Two-electrode voltage clamp (TEVC) recordings were performed on Xenopus oocytes at room temperature 3-6 days postinjection using an OC-725C TEVC ampl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rattus norvegicus (Rat))
Emory University

Curated by ChEMBL
LigandPNGBDBM50440060(CHEMBL2426081)
Affinity DataIC50:  170nMAssay Description:Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rattus norvegicus (Rat))
Emory University

Curated by ChEMBL
LigandPNGBDBM50440067(CHEMBL2426072 | CHEMBL2426073)
Affinity DataIC50:  190nMAssay Description:Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rattus norvegicus (Rat))
Emory University

Curated by ChEMBL
LigandPNGBDBM50440084(CHEMBL2426093)
Affinity DataIC50:  290nMAssay Description:Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rattus norvegicus (Rat))
Emory University

Curated by ChEMBL
LigandPNGBDBM50440065(CHEMBL2426075)
Affinity DataIC50:  320nMAssay Description:Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rattus norvegicus (Rat))
Emory University

Curated by ChEMBL
LigandPNGBDBM50440085(CHEMBL2426092)
Affinity DataIC50:  390nMAssay Description:Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rattus norvegicus (Rat))
Emory University

Curated by ChEMBL
LigandPNGBDBM50440057(CHEMBL2426097)
Affinity DataIC50:  440nMAssay Description:Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rattus norvegicus (Rat))
Emory University

Curated by ChEMBL
LigandPNGBDBM50440081(CHEMBL2426096)
Affinity DataIC50:  510nMAssay Description:Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rattus norvegicus (Rat))
Emory University

Curated by ChEMBL
LigandPNGBDBM50440077(CHEMBL2425977)
Affinity DataIC50:  530nMAssay Description:Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rattus norvegicus (Rat))
Emory University

Curated by ChEMBL
LigandPNGBDBM50440067(CHEMBL2426072 | CHEMBL2426073)
Affinity DataIC50:  570nMAssay Description:Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rattus norvegicus (Rat))
Emory University

Curated by ChEMBL
LigandPNGBDBM50440058(CHEMBL2426100)
Affinity DataIC50:  580nMAssay Description:Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rattus norvegicus (Rat))
Emory University

Curated by ChEMBL
LigandPNGBDBM50440074(CHEMBL2426065)
Affinity DataIC50:  660nMAssay Description:Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rattus norvegicus (Rat))
Emory University

Curated by ChEMBL
LigandPNGBDBM50440052(CHEMBL2426105)
Affinity DataIC50:  690nMAssay Description:Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rattus norvegicus (Rat))
Emory University

Curated by ChEMBL
LigandPNGBDBM50440063(CHEMBL2426077)
Affinity DataIC50:  690nMAssay Description:Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rattus norvegicus (Rat))
Emory University

Curated by ChEMBL
LigandPNGBDBM50440072(CHEMBL2426067)
Affinity DataIC50:  700nMAssay Description:Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rattus norvegicus (Rat))
Emory University

Curated by ChEMBL
LigandPNGBDBM50440073(CHEMBL2426066)
Affinity DataIC50:  810nMAssay Description:Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rattus norvegicus (Rat))
Emory University

Curated by ChEMBL
LigandPNGBDBM50440075(CHEMBL2425979)
Affinity DataIC50:  910nMAssay Description:Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rattus norvegicus (Rat))
Emory University

Curated by ChEMBL
LigandPNGBDBM50440076(CHEMBL2425978)
Affinity DataIC50:  1.00E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rattus norvegicus (Rat))
Emory University

Curated by ChEMBL
LigandPNGBDBM50440051(CHEMBL2425972)
Affinity DataIC50:  1.00E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rattus norvegicus (Rat))
Emory University

Curated by ChEMBL
LigandPNGBDBM50242447(CHEMBL525783)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of rat NMDA NR2D receptor expressed in xenopus oocytes coexpressing NMDA NR13b assessed as effect on glycine-induced current response at -...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rattus norvegicus (Rat))
Emory University

Curated by ChEMBL
LigandPNGBDBM50242449(CHEMBL525025 | conantokin-G)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of rat NMDA NR2D receptor expressed in xenopus oocytes coexpressing NMDA NR13b assessed as effect on glycine-induced current response at -...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rattus norvegicus (Rat))
Emory University

Curated by ChEMBL
LigandPNGBDBM50242446(CHEMBL524338)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of rat NMDA NR2D receptor expressed in xenopus oocytes coexpressing NMDA NR13b assessed as effect on glycine-induced current response at -...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rattus norvegicus (Rat))
Emory University

Curated by ChEMBL
LigandPNGBDBM50440091(CHEMBL2426086)
Affinity DataIC50:  1.10E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rattus norvegicus (Rat))
Emory University

Curated by ChEMBL
LigandPNGBDBM50440062(CHEMBL2426078)
Affinity DataIC50:  1.10E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2D(RAT)
Emory University

Curated by ChEMBL
LigandPNGBDBM50509842(CHEMBL4468229)
Affinity DataIC50:  1.30E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN1/GluN2D expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rattus norvegicus (Rat))
Emory University

Curated by ChEMBL
LigandPNGBDBM50440070(CHEMBL2426068 | CHEMBL2426069)
Affinity DataIC50:  1.40E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rattus norvegicus (Rat))
Emory University

Curated by ChEMBL
LigandPNGBDBM50440078(CHEMBL2426101)
Affinity DataIC50:  1.40E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2D(RAT)
Emory University

Curated by ChEMBL
LigandPNGBDBM50531773(CHEMBL4475740)
Affinity DataIC50:  1.40E+3nMAssay Description:Negative allosteric modulation of rat GluN1/GluN2D expressed in Xenopus laevis oocytes assessed as inhibition of L-glutamate/glycine-induced current ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rattus norvegicus (Rat))
Emory University

Curated by ChEMBL
LigandPNGBDBM50440061(CHEMBL2424674)
Affinity DataIC50:  1.70E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2D(RAT)
Emory University

Curated by ChEMBL
LigandPNGBDBM50509840(CHEMBL4528294)
Affinity DataIC50:  1.70E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN1/GluN2D expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rattus norvegicus (Rat))
Emory University

Curated by ChEMBL
LigandPNGBDBM50440050(CHEMBL2425973)
Affinity DataIC50:  1.90E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rattus norvegicus (Rat))
Emory University

Curated by ChEMBL
LigandPNGBDBM50440059(CHEMBL2426082)
Affinity DataIC50:  1.90E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2D(RAT)
Emory University

Curated by ChEMBL
LigandPNGBDBM50509834(CHEMBL4583491)
Affinity DataIC50:  2.20E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN1/GluN2D expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induce...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rattus norvegicus (Rat))
Emory University

Curated by ChEMBL
LigandPNGBDBM50440055(CHEMBL2426102)
Affinity DataIC50:  2.30E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rattus norvegicus (Rat))
Emory University

Curated by ChEMBL
LigandPNGBDBM50440047(CHEMBL2425976)
Affinity DataIC50:  2.60E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2D(RAT)
Emory University

Curated by ChEMBL
LigandPNGBDBM50509841(CHEMBL4445076)
Affinity DataIC50:  2.70E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN1/GluN2D expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rattus norvegicus (Rat))
Emory University

Curated by ChEMBL
LigandPNGBDBM50440053(CHEMBL2426104)
Affinity DataIC50:  2.80E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2D(RAT)
Emory University

Curated by ChEMBL
LigandPNGBDBM50531765(CHEMBL4534780)
Affinity DataIC50:  2.90E+3nMAssay Description:Negative allosteric modulation of rat GluN1/GluN2D expressed in Xenopus laevis oocytes assessed as inhibition of L-glutamate/glycine-induced current ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rattus norvegicus (Rat))
Emory University

Curated by ChEMBL
LigandPNGBDBM50440083(CHEMBL2426094)
Affinity DataIC50:  2.90E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2D(RAT)
Emory University

Curated by ChEMBL
LigandPNGBDBM50531766(CHEMBL4472540)
Affinity DataIC50:  2.90E+3nMAssay Description:Negative allosteric modulation of rat GluN1/GluN2D expressed in Xenopus laevis oocytes assessed as inhibition of L-glutamate/glycine-induced current ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rattus norvegicus (Rat))
University Of Copenhagen

LigandPNGBDBM213888(1-thioxo-1,2-dihydro-[1,2,4]triazolo[4,3-a]-quinox...)
Affinity DataKi: >300nM ΔG°: >-8.89kcal/mole IC50: >3.00E+3nMpH: 7.4 T: 2°CAssay Description:Two-electrode voltage clamp (TEVC) recordings were performed on Xenopus oocytes at room temperature 3-6 days postinjection using an OC-725C TEVC ampl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rattus norvegicus (Rat))
Emory University

Curated by ChEMBL
LigandPNGBDBM50440092(CHEMBL2426085)
Affinity DataIC50:  3.10E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rattus norvegicus (Rat))
Emory University

Curated by ChEMBL
LigandPNGBDBM50440080(CHEMBL2426098)
Affinity DataIC50:  3.40E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rattus norvegicus (Rat))
Emory University

Curated by ChEMBL
LigandPNGBDBM50440069(CHEMBL2426071)
Affinity DataIC50:  4.00E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rattus norvegicus (Rat))
Emory University

Curated by ChEMBL
LigandPNGBDBM50440089(CHEMBL2426089)
Affinity DataIC50:  4.10E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rattus norvegicus (Rat))
Emory University

Curated by ChEMBL
LigandPNGBDBM50440093(CHEMBL2426084)
Affinity DataIC50:  4.50E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rattus norvegicus (Rat))
Emory University

Curated by ChEMBL
LigandPNGBDBM50440049(CHEMBL2425974)
Affinity DataIC50:  4.50E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 2D(Rattus norvegicus (Rat))
Emory University

Curated by ChEMBL
LigandPNGBDBM50440070(CHEMBL2426068 | CHEMBL2426069)
Affinity DataIC50:  5.00E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN2D receptor expressed in Xenopus laevis oocytes by two-electrode voltage clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2D(RAT)
Emory University

Curated by ChEMBL
LigandPNGBDBM50509835(CHEMBL4443031)
Affinity DataIC50:  5.10E+3nMAssay Description:Negative allosteric modulation of recombinant rat GluN1/GluN2D expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlutamate receptor ionotropic, NMDA 1/2D(RAT)
Emory University

Curated by ChEMBL
LigandPNGBDBM50007024(CHEMBL3237304)
Affinity DataIC50:  5.70E+3nMAssay Description:Inhibition of rat recombinant GluN1/GluN2D expressed in Xenopus laevis oocytes assessed as reduction in current responseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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