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Compile Data Set for Download or QSAR

Found 46 hits of affinity data for UniProtKB/TrEMBL: Q00024   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM233016
PNG
(p-Xylidine-bis(dithiocarbamate) sodium salt (II))
Show SMILES [S-]C(=S)NCc1ccc(CNC([S-])=S)cc1
Show InChI InChI=1S/C10H12N2S4/c13-9(14)11-5-7-1-2-8(4-3-7)6-12-10(15)16/h1-4H,5-6H2,(H2,11,13,14)(H2,12,15,16)/p-2
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290 -37.6n/an/an/an/an/a6.827



University of Tehran



Assay Description
The assay was performed as previously described with slight modifications [Chen et al., J. Agric. Food Chem., 50:4108-12]. The reaction medium was 1 ...


J Enzyme Inhib Med Chem 25: 272-81 (2010)


Article DOI: 10.1080/14756360903179351
BindingDB Entry DOI: 10.7270/Q2000101
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM233016
PNG
(p-Xylidine-bis(dithiocarbamate) sodium salt (II))
Show SMILES [S-]C(=S)NCc1ccc(CNC([S-])=S)cc1
Show InChI InChI=1S/C10H12N2S4/c13-9(14)11-5-7-1-2-8(4-3-7)6-12-10(15)16/h1-4H,5-6H2,(H2,11,13,14)(H2,12,15,16)/p-2
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640 -35.6n/an/an/an/an/a6.827



University of Tehran



Assay Description
The assay was performed as previously described with slight modifications [Chen et al., J. Agric. Food Chem., 50:4108-12]. The reaction medium was 1 ...


J Enzyme Inhib Med Chem 25: 272-81 (2010)


Article DOI: 10.1080/14756360903179351
BindingDB Entry DOI: 10.7270/Q2000101
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM233016
PNG
(p-Xylidine-bis(dithiocarbamate) sodium salt (II))
Show SMILES [S-]C(=S)NCc1ccc(CNC([S-])=S)cc1
Show InChI InChI=1S/C10H12N2S4/c13-9(14)11-5-7-1-2-8(4-3-7)6-12-10(15)16/h1-4H,5-6H2,(H2,11,13,14)(H2,12,15,16)/p-2
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UniChem
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PubMed
950 -35.8n/an/an/an/an/a6.837



University of Tehran



Assay Description
The assay was performed as previously described with slight modifications [Chen et al., J. Agric. Food Chem., 50:4108-12]. The reaction medium was 1 ...


J Enzyme Inhib Med Chem 25: 272-81 (2010)


Article DOI: 10.1080/14756360903179351
BindingDB Entry DOI: 10.7270/Q2000101
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM233016
PNG
(p-Xylidine-bis(dithiocarbamate) sodium salt (II))
Show SMILES [S-]C(=S)NCc1ccc(CNC([S-])=S)cc1
Show InChI InChI=1S/C10H12N2S4/c13-9(14)11-5-7-1-2-8(4-3-7)6-12-10(15)16/h1-4H,5-6H2,(H2,11,13,14)(H2,12,15,16)/p-2
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UniChem
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PubMed
1.05E+3 -35.5n/an/an/an/an/a6.837



University of Tehran



Assay Description
The assay was performed as previously described with slight modifications [Chen et al., J. Agric. Food Chem., 50:4108-12]. The reaction medium was 1 ...


J Enzyme Inhib Med Chem 25: 272-81 (2010)


Article DOI: 10.1080/14756360903179351
BindingDB Entry DOI: 10.7270/Q2000101
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM50382706
PNG
(Benzyldithiocarbamate sodium salt (I) | CHEMBL2023...)
Show SMILES [S-]C(=S)NCc1ccccc1
Show InChI InChI=1S/C8H9NS2/c10-8(11)9-6-7-4-2-1-3-5-7/h1-5H,6H2,(H2,9,10,11)/p-1
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5.70E+3 -31.1n/an/an/an/an/a6.837



University of Tehran



Assay Description
The assay was performed as previously described with slight modifications [Chen et al., J. Agric. Food Chem., 50:4108-12]. The reaction medium was 1 ...


J Enzyme Inhib Med Chem 25: 272-81 (2010)


Article DOI: 10.1080/14756360903179351
BindingDB Entry DOI: 10.7270/Q2000101
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM50382706
PNG
(Benzyldithiocarbamate sodium salt (I) | CHEMBL2023...)
Show SMILES [S-]C(=S)NCc1ccccc1
Show InChI InChI=1S/C8H9NS2/c10-8(11)9-6-7-4-2-1-3-5-7/h1-5H,6H2,(H2,9,10,11)/p-1
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5.90E+3 -31.0n/an/an/an/an/a6.837



University of Tehran



Assay Description
The assay was performed as previously described with slight modifications [Chen et al., J. Agric. Food Chem., 50:4108-12]. The reaction medium was 1 ...


J Enzyme Inhib Med Chem 25: 272-81 (2010)


Article DOI: 10.1080/14756360903179351
BindingDB Entry DOI: 10.7270/Q2000101
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM50382706
PNG
(Benzyldithiocarbamate sodium salt (I) | CHEMBL2023...)
Show SMILES [S-]C(=S)NCc1ccccc1
Show InChI InChI=1S/C8H9NS2/c10-8(11)9-6-7-4-2-1-3-5-7/h1-5H,6H2,(H2,9,10,11)/p-1
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PubMed
9.40E+3 -28.9n/an/an/an/an/a6.827



University of Tehran



Assay Description
The assay was performed as previously described with slight modifications [Chen et al., J. Agric. Food Chem., 50:4108-12]. The reaction medium was 1 ...


J Enzyme Inhib Med Chem 25: 272-81 (2010)


Article DOI: 10.1080/14756360903179351
BindingDB Entry DOI: 10.7270/Q2000101
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM50382706
PNG
(Benzyldithiocarbamate sodium salt (I) | CHEMBL2023...)
Show SMILES [S-]C(=S)NCc1ccccc1
Show InChI InChI=1S/C8H9NS2/c10-8(11)9-6-7-4-2-1-3-5-7/h1-5H,6H2,(H2,9,10,11)/p-1
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1.41E+4 -27.9n/an/an/an/an/a6.827



University of Tehran



Assay Description
The assay was performed as previously described with slight modifications [Chen et al., J. Agric. Food Chem., 50:4108-12]. The reaction medium was 1 ...


J Enzyme Inhib Med Chem 25: 272-81 (2010)


Article DOI: 10.1080/14756360903179351
BindingDB Entry DOI: 10.7270/Q2000101
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM240726
PNG
(US9422261, Compound 4)
Show SMILES CC(c1ccsc1)c1ccc(O)cc1O
Show InChI InChI=1S/C12H12O2S/c1-8(9-4-5-15-7-9)11-3-2-10(13)6-12(11)14/h2-8,13-14H,1H3
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n/an/a 80n/an/an/an/a6.8n/a



PIERRE FABRE DERMO-COSMETIQUE

US Patent


Assay Description
Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...


US Patent US9422261 (2016)


BindingDB Entry DOI: 10.7270/Q2PG1QMS
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM240723
PNG
(US9422261, Compound 1)
Show SMILES CC(c1cccs1)c1ccc(O)cc1O
Show InChI InChI=1S/C12H12O2S/c1-8(12-3-2-6-15-12)10-5-4-9(13)7-11(10)14/h2-8,13-14H,1H3
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n/an/a 90n/an/an/an/a6.8n/a



PIERRE FABRE DERMO-COSMETIQUE

US Patent


Assay Description
Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...


US Patent US9422261 (2016)


BindingDB Entry DOI: 10.7270/Q2PG1QMS
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM240731
PNG
(US9422261, 4-(1- phenylethyl) benzene-1,3- diol)
Show SMILES CC(c1ccccc1)c1ccc(O)cc1O
Show InChI InChI=1S/C14H14O2/c1-10(11-5-3-2-4-6-11)13-8-7-12(15)9-14(13)16/h2-10,15-16H,1H3
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n/an/a 100n/an/an/an/a6.8n/a



PIERRE FABRE DERMO-COSMETIQUE

US Patent


Assay Description
Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...


US Patent US9422261 (2016)


BindingDB Entry DOI: 10.7270/Q2PG1QMS
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM240725
PNG
(US9422261, Compound 3)
Show SMILES CC(c1cccnc1)c1ccc(O)cc1O
Show InChI InChI=1S/C13H13NO2/c1-9(10-3-2-6-14-8-10)12-5-4-11(15)7-13(12)16/h2-9,15-16H,1H3
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US Patent
n/an/a 200n/an/an/an/a6.8n/a



PIERRE FABRE DERMO-COSMETIQUE

US Patent


Assay Description
Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...


US Patent US9422261 (2016)


BindingDB Entry DOI: 10.7270/Q2PG1QMS
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM240724
PNG
(US9422261, Compound 2)
Show SMILES CC(c1ccccn1)c1ccc(O)cc1O
Show InChI InChI=1S/C13H13NO2/c1-9(12-4-2-3-7-14-12)11-6-5-10(15)8-13(11)16/h2-9,15-16H,1H3
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US Patent
n/an/a 400n/an/an/an/a6.8n/a



PIERRE FABRE DERMO-COSMETIQUE

US Patent


Assay Description
Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...


US Patent US9422261 (2016)


BindingDB Entry DOI: 10.7270/Q2PG1QMS
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM50248158
PNG
(CHEMBL450195 | N-butylresorcinol | US8993596, 4-Bu...)
Show SMILES CCCCc1ccc(O)cc1O
Show InChI InChI=1S/C10H14O2/c1-2-3-4-8-5-6-9(11)7-10(8)12/h5-7,11-12H,2-4H2,1H3
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n/an/a 1.00E+3n/an/an/an/a6.8n/a



PIERRE FABRE DERMO-COSMETIQUE

US Patent


Assay Description
Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...


US Patent US9422261 (2016)


BindingDB Entry DOI: 10.7270/Q2PG1QMS
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM233168
PNG
(N-(2-Hydroxy-ethyl)-3,5-dinitro-benzamide (7))
Show SMILES OCCNC(=O)c1cc(cc(c1)[N+]([O-])=O)[N+]([O-])=O
Show InChI InChI=1S/C9H9N3O6/c13-2-1-10-9(14)6-3-7(11(15)16)5-8(4-6)12(17)18/h3-5,13H,1-2H2,(H,10,14)
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Article
PubMed
n/an/a 1.09E+3n/an/an/an/a6.825



Yonsei University



Assay Description
Tyrosinase inhibition assays were performed in a 96-well microplate format using the SpectraMax 340 microplate reader (Molecular Devices, CA) accordi...


J Enzyme Inhib Med Chem 25: 812-7 (2010)


Article DOI: 10.3109/14756366.2010.482529
BindingDB Entry DOI: 10.7270/Q2NK3CX5
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM234394
PNG
(Polyhydroxy benzophenone, 10)
Show SMILES Oc1ccc(C(=O)c2cc(O)c(O)c(O)c2)c(O)c1O
Show InChI InChI=1S/C13H10O7/c14-7-2-1-6(11(18)13(7)20)10(17)5-3-8(15)12(19)9(16)4-5/h1-4,14-16,18-20H
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n/an/a 1.40E+3n/an/an/an/a6.825



Sun Yat-sen University



Assay Description
In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...


J Enzyme Inhib Med Chem 26: 449-52 (2011)


Article DOI: 10.3109/14756366.2010.521745
BindingDB Entry DOI: 10.7270/Q2NC603X
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM240727
PNG
(US9422261, Compound 5)
Show SMILES CC(c1nccs1)c1ccc(O)cc1O
Show InChI InChI=1S/C11H11NO2S/c1-7(11-12-4-5-15-11)9-3-2-8(13)6-10(9)14/h2-7,13-14H,1H3
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US Patent
n/an/a 1.50E+3n/an/an/an/a6.8n/a



PIERRE FABRE DERMO-COSMETIQUE

US Patent


Assay Description
Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...


US Patent US9422261 (2016)


BindingDB Entry DOI: 10.7270/Q2PG1QMS
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM240729
PNG
(US9422261, Unigen resorcinol derivative | US968291...)
Show SMILES Oc1ccc(Cc2cccnc2)c(O)c1
Show InChI InChI=1S/C12H11NO2/c14-11-4-3-10(12(15)7-11)6-9-2-1-5-13-8-9/h1-5,7-8,14-15H,6H2
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US Patent
n/an/a 2.00E+3n/an/an/an/a6.8n/a



PIERRE FABRE DERMO-COSMETIQUE

US Patent


Assay Description
Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...


US Patent US9422261 (2016)


BindingDB Entry DOI: 10.7270/Q2PG1QMS
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM233170
PNG
(N-Hydroxy-4,N-dimethyl-benzamide (9))
Show SMILES CN(O)C(=O)c1ccc(C)cc1
Show InChI InChI=1S/C9H11NO2/c1-7-3-5-8(6-4-7)9(11)10(2)12/h3-6,12H,1-2H3
UniProtKB/SwissProt

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PC sid
UniChem
Article
PubMed
n/an/a 2.09E+3n/an/an/an/a6.825



Yonsei University



Assay Description
Tyrosinase inhibition assays were performed in a 96-well microplate format using the SpectraMax 340 microplate reader (Molecular Devices, CA) accordi...


J Enzyme Inhib Med Chem 25: 812-7 (2010)


Article DOI: 10.3109/14756366.2010.482529
BindingDB Entry DOI: 10.7270/Q2NK3CX5
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM233169
PNG
(N-(2-Bromo-ethyl)-3,5-dinitro-benzamide (8))
Show SMILES [O-][N+](=O)c1cc(cc(c1)[N+]([O-])=O)C(=O)NCCBr
Show InChI InChI=1S/C9H8BrN3O5/c10-1-2-11-9(14)6-3-7(12(15)16)5-8(4-6)13(17)18/h3-5H,1-2H2,(H,11,14)
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PubMed
n/an/a 3.08E+3n/an/an/an/a6.825



Yonsei University



Assay Description
Tyrosinase inhibition assays were performed in a 96-well microplate format using the SpectraMax 340 microplate reader (Molecular Devices, CA) accordi...


J Enzyme Inhib Med Chem 25: 812-7 (2010)


Article DOI: 10.3109/14756366.2010.482529
BindingDB Entry DOI: 10.7270/Q2NK3CX5
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM50198715
PNG
((2S)-2-amino-3-(3-hydroxy-4-oxopyridin-1(4H)-yl)pr...)
Show SMILES N[C@@H](Cn1ccc(=O)c(O)c1)C(O)=O
Show InChI InChI=1S/C8H10N2O4/c9-5(8(13)14)3-10-2-1-6(11)7(12)4-10/h1-2,4-5,12H,3,9H2,(H,13,14)/t5-/m0/s1
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n/an/a 3.68E+3n/an/an/an/a6.825



Yonsei University



Assay Description
Tyrosinase inhibition assays were performed in a 96-well microplate format using the SpectraMax 340 microplate reader (Molecular Devices, CA) accordi...


J Enzyme Inhib Med Chem 25: 812-7 (2010)


Article DOI: 10.3109/14756366.2010.482529
BindingDB Entry DOI: 10.7270/Q2NK3CX5
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM240730
PNG
(US9422261, Unigen resorcinol derivative | US968291...)
Show SMILES OC(c1cccnc1)c1ccc(O)cc1O
Show InChI InChI=1S/C12H11NO3/c14-9-3-4-10(11(15)6-9)12(16)8-2-1-5-13-7-8/h1-7,12,14-16H
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US Patent
n/an/a 4.90E+3n/an/an/an/a6.8n/a



PIERRE FABRE DERMO-COSMETIQUE

US Patent


Assay Description
Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...


US Patent US9422261 (2016)


BindingDB Entry DOI: 10.7270/Q2PG1QMS
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM234393
PNG
(Polyhydroxy benzophenone, 9)
Show SMILES COc1cc(ccc1O)C(=O)c1ccc(O)c(O)c1O
Show InChI InChI=1S/C14H12O6/c1-20-11-6-7(2-4-9(11)15)12(17)8-3-5-10(16)14(19)13(8)18/h2-6,15-16,18-19H,1H3
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n/an/a 6.40E+3n/an/an/an/a6.825



Sun Yat-sen University



Assay Description
In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...


J Enzyme Inhib Med Chem 26: 449-52 (2011)


Article DOI: 10.3109/14756366.2010.521745
BindingDB Entry DOI: 10.7270/Q2NC603X
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM50249353
PNG
(1,1,3-trihydroxybenzophenone | 2,2',4-trihydroxybe...)
Show SMILES Oc1ccc(C(=O)c2ccccc2O)c(O)c1
Show InChI InChI=1S/C13H10O4/c14-8-5-6-10(12(16)7-8)13(17)9-3-1-2-4-11(9)15/h1-7,14-16H
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n/an/a 7.30E+3n/an/an/an/a6.825



Sun Yat-sen University



Assay Description
In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...


J Enzyme Inhib Med Chem 26: 449-52 (2011)


Article DOI: 10.3109/14756366.2010.521745
BindingDB Entry DOI: 10.7270/Q2NC603X
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM234397
PNG
(Polyhydroxy benzophenone, 15)
Show SMILES Oc1ccc(C(=O)c2ccccc2O)c(O)c1O
Show InChI InChI=1S/C13H10O5/c14-9-4-2-1-3-7(9)11(16)8-5-6-10(15)13(18)12(8)17/h1-6,14-15,17-18H
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n/an/a 8.80E+3n/an/an/an/a6.825



Sun Yat-sen University



Assay Description
In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...


J Enzyme Inhib Med Chem 26: 449-52 (2011)


Article DOI: 10.3109/14756366.2010.521745
BindingDB Entry DOI: 10.7270/Q2NC603X
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM225847
PNG
(Polyhydroxy benzophenone, 8 | hsp90_138)
Show SMILES Oc1ccc(C(=O)c2ccc(O)c(O)c2O)c(O)c1
Show InChI InChI=1S/C13H10O6/c14-6-1-2-7(10(16)5-6)11(17)8-3-4-9(15)13(19)12(8)18/h1-5,14-16,18-19H
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n/an/a 1.01E+4n/an/an/an/a6.825



Sun Yat-sen University



Assay Description
In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...


J Enzyme Inhib Med Chem 26: 449-52 (2011)


Article DOI: 10.3109/14756366.2010.521745
BindingDB Entry DOI: 10.7270/Q2NC603X
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM50234650
PNG
(2,3,4-trihydroxybenzophenone | CHEMBL1527 | Polyhy...)
Show SMILES Oc1ccc(C(=O)c2ccccc2)c(O)c1O
Show InChI InChI=1S/C13H10O4/c14-10-7-6-9(12(16)13(10)17)11(15)8-4-2-1-3-5-8/h1-7,14,16-17H
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n/an/a 1.05E+4n/an/an/an/a6.825



Sun Yat-sen University



Assay Description
In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...


J Enzyme Inhib Med Chem 26: 449-52 (2011)


Article DOI: 10.3109/14756366.2010.521745
BindingDB Entry DOI: 10.7270/Q2NC603X
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM233171
PNG
(N-Ethyl-benzamide (10))
Show SMILES CCNC(=O)c1ccccc1
Show InChI InChI=1S/C9H11NO/c1-2-10-9(11)8-6-4-3-5-7-8/h3-7H,2H2,1H3,(H,10,11)
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n/an/a 1.18E+4n/an/an/an/a6.825



Yonsei University



Assay Description
Tyrosinase inhibition assays were performed in a 96-well microplate format using the SpectraMax 340 microplate reader (Molecular Devices, CA) accordi...


J Enzyme Inhib Med Chem 25: 812-7 (2010)


Article DOI: 10.3109/14756366.2010.482529
BindingDB Entry DOI: 10.7270/Q2NK3CX5
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM233166
PNG
(3-Methyl-2-butenyl-4-hydroxybenzoate (2))
Show SMILES CC(C)=CCOC(=O)c1ccc(O)cc1
Show InChI InChI=1S/C12H14O3/c1-9(2)7-8-15-12(14)10-3-5-11(13)6-4-10/h3-7,13H,8H2,1-2H3
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n/an/a 1.48E+4n/an/an/an/a6.825



Yonsei University



Assay Description
Tyrosinase inhibition assays were performed in a 96-well microplate format using the SpectraMax 340 microplate reader (Molecular Devices, CA) accordi...


J Enzyme Inhib Med Chem 25: 812-7 (2010)


Article DOI: 10.3109/14756366.2010.482529
BindingDB Entry DOI: 10.7270/Q2NK3CX5
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 1.50E+4n/an/an/an/a6.8n/a



PIERRE FABRE DERMO-COSMETIQUE

US Patent


Assay Description
Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...


US Patent US9422261 (2016)


BindingDB Entry DOI: 10.7270/Q2PG1QMS
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM50031467
PNG
(5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hyd...)
Show SMILES OCc1cc(=O)c(O)co1
Show InChI InChI=1S/C6H6O4/c7-2-4-1-5(8)6(9)3-10-4/h1,3,7,9H,2H2
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n/an/a 1.67E+4n/an/an/an/a6.825



Yonsei University



Assay Description
Tyrosinase inhibition assays were performed in a 96-well microplate format using the SpectraMax 340 microplate reader (Molecular Devices, CA) accordi...


J Enzyme Inhib Med Chem 25: 812-7 (2010)


Article DOI: 10.3109/14756366.2010.482529
BindingDB Entry DOI: 10.7270/Q2NK3CX5
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM234392
PNG
(Polyhydroxy benzophenone, 6)
Show SMILES Oc1ccc(C(=O)c2cc(O)c(O)c(O)c2)c(O)c1
Show InChI InChI=1S/C13H10O6/c14-7-1-2-8(9(15)5-7)12(18)6-3-10(16)13(19)11(17)4-6/h1-5,14-17,19H
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n/an/a 1.74E+4n/an/an/an/a6.825



Sun Yat-sen University



Assay Description
In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...


J Enzyme Inhib Med Chem 26: 449-52 (2011)


Article DOI: 10.3109/14756366.2010.521745
BindingDB Entry DOI: 10.7270/Q2NC603X
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM233167
PNG
(4-Nitro-phenyl-(4-nitro-2-trifluoromethyl)-benzoat...)
Show SMILES [O-][N+](=O)c1ccc(OC(=O)c2ccc(cc2C(F)(F)F)[N+]([O-])=O)cc1
Show InChI InChI=1S/C14H7F3N2O6/c15-14(16,17)12-7-9(19(23)24)3-6-11(12)13(20)25-10-4-1-8(2-5-10)18(21)22/h1-7H
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n/an/a 2.97E+4n/an/an/an/a6.825



Yonsei University



Assay Description
Tyrosinase inhibition assays were performed in a 96-well microplate format using the SpectraMax 340 microplate reader (Molecular Devices, CA) accordi...


J Enzyme Inhib Med Chem 25: 812-7 (2010)


Article DOI: 10.3109/14756366.2010.482529
BindingDB Entry DOI: 10.7270/Q2NK3CX5
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM241950
PNG
(Neolitsea aciculata extract, 5)
Show SMILES CC1OC(Oc2c(oc3cc(O)cc(O)c3c2=O)-c2ccc(O)cc2)C(OC(=O)\C=C\c2ccc(O)cc2)C(OC(=O)\C=C\c2ccc(O)cc2)C1O
Show InChI InChI=1S/C39H32O14/c1-20-33(47)36(51-30(45)16-6-21-2-10-24(40)11-3-21)38(52-31(46)17-7-22-4-12-25(41)13-5-22)39(49-20)53-37-34(48)32-28(44)18-27(43)19-29(32)50-35(37)23-8-14-26(42)15-9-23/h2-20,33,36,38-44,47H,1H3/b16-6+,17-7+
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n/an/a 6.70E+4n/an/an/an/a6.837



Jeju National University



Assay Description
Briefly, mushroom tyrosinase (1250 units/mL) and 2 mM L-tyrosine (0.07 mL) were added to a solution of phosphate buffer (0.1 M, pH 6.8, 0.09 mL) cont...


J Enzyme Inhib Med Chem 28: 685-9 (2013)


Article DOI: 10.3109/14756366.2012.670806
BindingDB Entry DOI: 10.7270/Q2XS5T9S
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM241951
PNG
(Neolitsea aciculata extract, 6)
Show SMILES CC1OC(Oc2c(oc3cc(O)cc(O)c3c2=O)-c2ccc(O)cc2)C(OC(=O)\C=C\c2ccc(O)cc2)C(O)C1O
Show InChI InChI=1S/C30H26O12/c1-14-24(36)26(38)29(41-22(35)11-4-15-2-7-17(31)8-3-15)30(39-14)42-28-25(37)23-20(34)12-19(33)13-21(23)40-27(28)16-5-9-18(32)10-6-16/h2-14,24,26,29-34,36,38H,1H3/b11-4+
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n/an/a 8.00E+4n/an/an/an/a6.837



Jeju National University



Assay Description
Briefly, mushroom tyrosinase (1250 units/mL) and 2 mM L-tyrosine (0.07 mL) were added to a solution of phosphate buffer (0.1 M, pH 6.8, 0.09 mL) cont...


J Enzyme Inhib Med Chem 28: 685-9 (2013)


Article DOI: 10.3109/14756366.2012.670806
BindingDB Entry DOI: 10.7270/Q2XS5T9S
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM233165
PNG
(3-Methyl-2-butenylbenzoate (1))
Show SMILES CC(C)=CCOC(=O)c1ccccc1
Show InChI InChI=1S/C12H14O2/c1-10(2)8-9-14-12(13)11-6-4-3-5-7-11/h3-8H,9H2,1-2H3
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n/an/a 8.34E+4n/an/an/an/a6.825



Yonsei University



Assay Description
Tyrosinase inhibition assays were performed in a 96-well microplate format using the SpectraMax 340 microplate reader (Molecular Devices, CA) accordi...


J Enzyme Inhib Med Chem 25: 812-7 (2010)


Article DOI: 10.3109/14756366.2010.482529
BindingDB Entry DOI: 10.7270/Q2NK3CX5
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM240728
PNG
(US9422261, Arbutin)
Show SMILES OCC1O[C@@H](Oc2ccc(O)cc2)C(O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C12H16O7/c13-5-8-9(15)10(16)11(17)12(19-8)18-7-3-1-6(14)2-4-7/h1-4,8-17H,5H2/t8?,9-,10+,11?,12-/m1/s1
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n/an/a 9.00E+4n/an/an/an/a6.8n/a



PIERRE FABRE DERMO-COSMETIQUE

US Patent


Assay Description
Reader: Synergy HT program: tyrosinase 280-490 kinetics: kinetics over 45 minutes, reading at t=10 minutes, Tests in transparent 96-well plates, Phos...


US Patent US9422261 (2016)


BindingDB Entry DOI: 10.7270/Q2PG1QMS
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM234396
PNG
(Polyhydroxy benzophenone, 14)
Show SMILES Oc1ccc(cc1)C(=O)c1cc(O)c(O)c(O)c1
Show InChI InChI=1S/C13H10O5/c14-9-3-1-7(2-4-9)12(17)8-5-10(15)13(18)11(16)6-8/h1-6,14-16,18H
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n/an/a 9.83E+4n/an/an/an/a6.825



Sun Yat-sen University



Assay Description
In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...


J Enzyme Inhib Med Chem 26: 449-52 (2011)


Article DOI: 10.3109/14756366.2010.521745
BindingDB Entry DOI: 10.7270/Q2NC603X
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM225845
PNG
(Polyhydroxy benzophenone, 7 | hsp90_136)
Show SMILES Oc1ccc(cc1)C(=O)c1ccc(O)c(O)c1O
Show InChI InChI=1S/C13H10O5/c14-8-3-1-7(2-4-8)11(16)9-5-6-10(15)13(18)12(9)17/h1-6,14-15,17-18H
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n/an/a>1.00E+5n/an/an/an/a6.825



Sun Yat-sen University



Assay Description
In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...


J Enzyme Inhib Med Chem 26: 449-52 (2011)


Article DOI: 10.3109/14756366.2010.521745
BindingDB Entry DOI: 10.7270/Q2NC603X
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM234399
PNG
(Polyhydroxy benzophenone, 18)
Show SMILES Oc1cccc(C(=O)c2ccccc2)c1O
Show InChI InChI=1S/C13H10O3/c14-11-8-4-7-10(13(11)16)12(15)9-5-2-1-3-6-9/h1-8,14,16H
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n/an/a>2.00E+5n/an/an/an/a6.825



Sun Yat-sen University



Assay Description
In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...


J Enzyme Inhib Med Chem 26: 449-52 (2011)


Article DOI: 10.3109/14756366.2010.521745
BindingDB Entry DOI: 10.7270/Q2NC603X
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM234390
PNG
(Polyhydroxy benzophenone, 4)
Show SMILES Oc1ccc(C(=O)c2ccc(O)cc2O)c(O)c1
Show InChI InChI=1S/C13H10O5/c14-7-1-3-9(11(16)5-7)13(18)10-4-2-8(15)6-12(10)17/h1-6,14-17H
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n/an/a>2.00E+5n/an/an/an/a6.825



Sun Yat-sen University



Assay Description
In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...


J Enzyme Inhib Med Chem 26: 449-52 (2011)


Article DOI: 10.3109/14756366.2010.521745
BindingDB Entry DOI: 10.7270/Q2NC603X
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM225876
PNG
(Polyhydroxy benzophenone, 12 | hsp90_175)
Show SMILES Oc1ccc(C(=O)c2cccc(O)c2)c(O)c1
Show InChI InChI=1S/C13H10O4/c14-9-3-1-2-8(6-9)13(17)11-5-4-10(15)7-12(11)16/h1-7,14-16H
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n/an/a>2.00E+5n/an/an/an/a6.825



Sun Yat-sen University



Assay Description
In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...


J Enzyme Inhib Med Chem 26: 449-52 (2011)


Article DOI: 10.3109/14756366.2010.521745
BindingDB Entry DOI: 10.7270/Q2NC603X
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM234395
PNG
(Polyhydroxy benzophenone, 11)
Show SMILES Oc1ccc(C(=O)c2c(O)cc(O)cc2O)c(O)c1
Show InChI InChI=1S/C13H10O6/c14-6-1-2-8(9(16)3-6)13(19)12-10(17)4-7(15)5-11(12)18/h1-5,14-18H
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n/an/a>2.00E+5n/an/an/an/a6.825



Sun Yat-sen University



Assay Description
In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...


J Enzyme Inhib Med Chem 26: 449-52 (2011)


Article DOI: 10.3109/14756366.2010.521745
BindingDB Entry DOI: 10.7270/Q2NC603X
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM234398
PNG
(Polyhydroxy benzophenone, 16)
Show SMILES Oc1cc(O)c(C(=O)c2ccccc2)c(O)c1
Show InChI InChI=1S/C13H10O4/c14-9-6-10(15)12(11(16)7-9)13(17)8-4-2-1-3-5-8/h1-7,14-16H
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n/an/a>2.00E+5n/an/an/an/a6.825



Sun Yat-sen University



Assay Description
In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...


J Enzyme Inhib Med Chem 26: 449-52 (2011)


Article DOI: 10.3109/14756366.2010.521745
BindingDB Entry DOI: 10.7270/Q2NC603X
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM234391
PNG
(Polyhydroxy benzophenone, 5)
Show SMILES COc1cc(ccc1O)C(=O)c1ccc(O)cc1O
Show InChI InChI=1S/C14H12O5/c1-19-13-6-8(2-5-11(13)16)14(18)10-4-3-9(15)7-12(10)17/h2-7,15-17H,1H3
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n/an/a>2.00E+5n/an/an/an/a6.825



Sun Yat-sen University



Assay Description
In brief, a 10 μL sample was added to an assay mixture containing with 10 μL tyrosinase solution (0.5 mg/mL) and 900 μL phosphate buff...


J Enzyme Inhib Med Chem 26: 449-52 (2011)


Article DOI: 10.3109/14756366.2010.521745
BindingDB Entry DOI: 10.7270/Q2NC603X
More data for this
Ligand-Target Pair
Tyrosinase


(Agaricus bisporus (White button mushroom))
BDBM50219502
PNG
(4-hydroxyphenyl beta-D-glucopyranoside | Arbutin |...)
Show SMILES OC[C@H]1O[C@@H](Oc2ccc(O)cc2)[C@H](O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C12H16O7/c13-5-8-9(15)10(16)11(17)12(19-8)18-7-3-1-6(14)2-4-7/h1-4,8-17H,5H2/t8-,9-,10+,11-,12-/m1/s1
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n/an/a 3.20E+5n/an/an/an/a6.837



Jeju National University



Assay Description
Briefly, mushroom tyrosinase (1250 units/mL) and 2 mM L-tyrosine (0.07 mL) were added to a solution of phosphate buffer (0.1 M, pH 6.8, 0.09 mL) cont...


J Enzyme Inhib Med Chem 28: 685-9 (2013)


Article DOI: 10.3109/14756366.2012.670806
BindingDB Entry DOI: 10.7270/Q2XS5T9S
More data for this
Ligand-Target Pair