BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 218 hits Enz. Inhib. hit(s) with all data for entry = 1331   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317359
PNG
(US9617282, Example 132)
Show SMILES O=C1Nc2cn(nc2C(=O)NCCCCNc2cc(ccn2)-c2nc1cs2)C1CCOCC1
Show InChI InChI=1S/C22H25N7O3S/c30-20-17-13-33-22(27-17)14-3-8-24-18(11-14)23-6-1-2-7-25-21(31)19-16(26-20)12-29(28-19)15-4-9-32-10-5-15/h3,8,11-13,15H,1-2,4-7,9-10H2,(H,23,24)(H,25,31)(H,26,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317361
PNG
(US9617282, Example 134)
Show SMILES O=C1Nc2cn(nc2C(=O)NCCOCCc2cc(ccn2)-c2nc1cs2)C1CCOCC1
Show InChI InChI=1S/C22H24N6O4S/c29-20-18-13-33-22(26-18)14-1-5-23-15(11-14)2-7-32-10-6-24-21(30)19-17(25-20)12-28(27-19)16-3-8-31-9-4-16/h1,5,11-13,16H,2-4,6-10H2,(H,24,30)(H,25,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317362
PNG
(US9617282, Example 135)
Show SMILES Cn1cc2NC(=O)c3csc(n3)-c3cnn(CCCOCCNC(=O)c2n1)c3
Show InChI InChI=1S/C17H19N7O3S/c1-23-9-12-14(22-23)16(26)18-3-6-27-5-2-4-24-8-11(7-19-24)17-21-13(10-28-17)15(25)20-12/h7-10H,2-6H2,1H3,(H,18,26)(H,20,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317363
PNG
(US9617282, Example 136)
Show SMILES O=C1NCCOCCCn2cc(cn2)-c2nc(cs2)C(=O)Nc2cn(nc12)C1CCOCC1
Show InChI InChI=1S/C21H25N7O4S/c29-19-17-13-33-21(25-17)14-10-23-27(11-14)5-1-6-31-9-4-22-20(30)18-16(24-19)12-28(26-18)15-2-7-32-8-3-15/h10-13,15H,1-9H2,(H,22,30)(H,24,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317364
PNG
(US9617282, Example 137)
Show SMILES CC(C)(C)OC(=O)Cn1cc2NC(=O)c3csc(n3)-c3ccnc(OCCOCCNC(=O)c2n1)c3
Show InChI InChI=1S/C23H26N6O6S/c1-23(2,3)35-18(30)12-29-11-15-19(28-29)21(32)25-6-7-33-8-9-34-17-10-14(4-5-24-17)22-27-16(13-36-22)20(31)26-15/h4-5,10-11,13H,6-9,12H2,1-3H3,(H,25,32)(H,26,31)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317365
PNG
(US9617282, Example 138)
Show SMILES CN(C)CCCn1cc2NC(=O)c3csc(n3)-c3ccnc(OCCOCCNC(=O)c2n1)c3
Show InChI InChI=1S/C22H27N7O4S/c1-28(2)7-3-8-29-13-16-19(27-29)21(31)24-6-9-32-10-11-33-18-12-15(4-5-23-18)22-26-17(14-34-22)20(30)25-16/h4-5,12-14H,3,6-11H2,1-2H3,(H,24,31)(H,25,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317366
PNG
(US9617282, Example 139)
Show SMILES CCn1cc2NC(=O)c3csc(n3)-c3ccnc(OCCOCCNC(=O)c2n1)c3
Show InChI InChI=1S/C19H20N6O4S/c1-2-25-10-13-16(24-25)18(27)21-5-6-28-7-8-29-15-9-12(3-4-20-15)19-23-14(11-30-19)17(26)22-13/h3-4,9-11H,2,5-8H2,1H3,(H,21,27)(H,22,26)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317367
PNG
(US9617282, Example 140)
Show SMILES Cn1cc2NC(=O)c3coc(n3)-c3ccnc(NCCC\C=C\CCCNC(=O)c2n1)c3
Show InChI InChI=1S/C22H25N7O3/c1-29-13-16-19(28-29)21(31)25-10-7-5-3-2-4-6-9-23-18-12-15(8-11-24-18)22-27-17(14-32-22)20(30)26-16/h2-3,8,11-14H,4-7,9-10H2,1H3,(H,23,24)(H,25,31)(H,26,30)/b3-2+
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317370
PNG
(US9617282, Example 143)
Show SMILES CN1CCN(CCn2cc3NC(=O)c4csc(n4)-c4ccnc(NCCOCCNC(=O)c3n2)c4)CC1
Show InChI InChI=1S/C24H31N9O3S/c1-31-6-8-32(9-7-31)10-11-33-15-18-21(30-33)23(35)27-5-13-36-12-4-26-20-14-17(2-3-25-20)24-29-19(16-37-24)22(34)28-18/h2-3,14-16H,4-13H2,1H3,(H,25,26)(H,27,35)(H,28,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317371
PNG
(US9617282, Example 144)
Show SMILES CC(C)(C)OC(=O)N1CCN(CCn2cc3NC(=O)c4csc(n4)-c4ccnc(NCCOCCNC(=O)c3n2)c4)CC1
Show InChI InChI=1S/C28H37N9O5S/c1-28(2,3)42-27(40)36-11-8-35(9-12-36)10-13-37-17-20-23(34-37)25(39)31-7-15-41-14-6-30-22-16-19(4-5-29-22)26-33-21(18-43-26)24(38)32-20/h4-5,16-18H,6-15H2,1-3H3,(H,29,30)(H,31,39)(H,32,38)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317372
PNG
(US9617282, Example 145)
Show SMILES O=C1Nc2cn(CCN3CCNCC3)nc2C(=O)NCCOCCNc2cc(ccn2)-c2nc1cs2
Show InChI InChI=1S/C23H29N9O3S/c33-21-18-15-36-23(29-18)16-1-2-25-19(13-16)26-5-11-35-12-6-27-22(34)20-17(28-21)14-32(30-20)10-9-31-7-3-24-4-8-31/h1-2,13-15,24H,3-12H2,(H,25,26)(H,27,34)(H,28,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317377
PNG
(US9617282, Example 150)
Show SMILES CCOC(=O)CCn1cc2NC(=O)c3csc(n3)-c3ccnc(OCCOCCNC(=O)c2n1)c3
Show InChI InChI=1S/C22H24N6O6S/c1-2-33-18(29)4-7-28-12-15-19(27-28)21(31)24-6-8-32-9-10-34-17-11-14(3-5-23-17)22-26-16(13-35-22)20(30)25-15/h3,5,11-13H,2,4,6-10H2,1H3,(H,24,31)(H,25,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317379
PNG
(US9617282, Example 152)
Show SMILES OCCCn1cc2NC(=O)c3csc(n3)-c3ccnc(OCCOCCNC(=O)c2n1)c3
Show InChI InChI=1S/C20H22N6O5S/c27-6-1-5-26-11-14-17(25-26)19(29)22-4-7-30-8-9-31-16-10-13(2-3-21-16)20-24-15(12-32-20)18(28)23-14/h2-3,10-12,27H,1,4-9H2,(H,22,29)(H,23,28)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317380
PNG
(US9617282, Example 153)
Show SMILES CN1CCC(CCn2cc3NC(=O)c4csc(n4)-c4ccnc(OCCOCCNC(=O)c3n2)c4)CC1
Show InChI InChI=1S/C25H31N7O4S/c1-31-8-3-17(4-9-31)5-10-32-15-19-22(30-32)24(34)27-7-11-35-12-13-36-21-14-18(2-6-26-21)25-29-20(16-37-25)23(33)28-19/h2,6,14-17H,3-5,7-13H2,1H3,(H,27,34)(H,28,33)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317381
PNG
(US9617282, Example 154)
Show SMILES CC(C)(C)OC(=O)N1CCC(CCn2cc3NC(=O)c4csc(n4)-c4ccnc(OCCOCCNC(=O)c3n2)c4)CC1
Show InChI InChI=1S/C29H37N7O6S/c1-29(2,3)42-28(39)35-10-5-19(6-11-35)7-12-36-17-21-24(34-36)26(38)31-9-13-40-14-15-41-23-16-20(4-8-30-23)27-33-22(18-43-27)25(37)32-21/h4,8,16-19H,5-7,9-15H2,1-3H3,(H,31,38)(H,32,37)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317382
PNG
(US9617282, Example 155)
Show SMILES O=C1NCCOCCOc2cc(ccn2)-c2nc(cs2)C(=O)Nc2cn(CCC3CCNCC3)nc12
Show InChI InChI=1S/C24H29N7O4S/c32-22-19-15-36-24(29-19)17-3-7-26-20(13-17)35-12-11-34-10-8-27-23(33)21-18(28-22)14-31(30-21)9-4-16-1-5-25-6-2-16/h3,7,13-16,25H,1-2,4-6,8-12H2,(H,27,33)(H,28,32)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317386
PNG
(US9617282, Example 159)
Show SMILES CC(C)(C)OC(=O)N1CCC(Cn2cc3NC(=O)c4csc(n4)-c4ccnc(OCCOCCNC(=O)c3n2)c4)CC1
Show InChI InChI=1S/C28H35N7O6S/c1-28(2,3)41-27(38)34-9-5-18(6-10-34)15-35-16-20-23(33-35)25(37)30-8-11-39-12-13-40-22-14-19(4-7-29-22)26-32-21(17-42-26)24(36)31-20/h4,7,14,16-18H,5-6,8-13,15H2,1-3H3,(H,30,37)(H,31,36)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317388
PNG
(US9617282, Example 161)
Show SMILES CNC(=O)Cn1cc2NC(=O)c3csc(n3)-c3ccnc(OCCOCCNC(=O)c2n1)c3
Show InChI InChI=1S/C20H21N7O5S/c1-21-15(28)10-27-9-13-17(26-27)19(30)23-4-5-31-6-7-32-16-8-12(2-3-22-16)20-25-14(11-33-20)18(29)24-13/h2-3,8-9,11H,4-7,10H2,1H3,(H,21,28)(H,23,30)(H,24,29)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317389
PNG
(US9617282, Example 162)
Show SMILES CC(C)n1cc2NC(=O)c3csc(n3)-c3ccnc(OCCOCCNC(=O)c2n1)c3
Show InChI InChI=1S/C20H22N6O4S/c1-12(2)26-10-14-17(25-26)19(28)22-5-6-29-7-8-30-16-9-13(3-4-21-16)20-24-15(11-31-20)18(27)23-14/h3-4,9-12H,5-8H2,1-2H3,(H,22,28)(H,23,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317390
PNG
(US9617282, Example 163)
Show SMILES CN1CCC(CC1)n1cc2NC(=O)c3csc(n3)-c3ccnc(OCCOCCNC(=O)c2n1)c3
Show InChI InChI=1S/C23H27N7O4S/c1-29-7-3-16(4-8-29)30-13-17-20(28-30)22(32)25-6-9-33-10-11-34-19-12-15(2-5-24-19)23-27-18(14-35-23)21(31)26-17/h2,5,12-14,16H,3-4,6-11H2,1H3,(H,25,32)(H,26,31)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317391
PNG
(US9617282, Example 164)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)n1cc2NC(=O)c3csc(n3)-c3ccnc(OCCOCCNC(=O)c2n1)c3
Show InChI InChI=1S/C27H33N7O6S/c1-27(2,3)40-26(37)33-9-5-18(6-10-33)34-15-19-22(32-34)24(36)29-8-11-38-12-13-39-21-14-17(4-7-28-21)25-31-20(16-41-25)23(35)30-19/h4,7,14-16,18H,5-6,8-13H2,1-3H3,(H,29,36)(H,30,35)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317392
PNG
(US9617282, Example 165)
Show SMILES O=C1Nc2cn(nc2C(=O)NCCOCCOc2cc(ccn2)-c2nc1cs2)C1CCNCC1
Show InChI InChI=1S/C22H25N7O4S/c30-20-17-13-34-22(27-17)14-1-6-24-18(11-14)33-10-9-32-8-7-25-21(31)19-16(26-20)12-29(28-19)15-2-4-23-5-3-15/h1,6,11-13,15,23H,2-5,7-10H2,(H,25,31)(H,26,30)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317395
PNG
(US9617282, Example 168)
Show SMILES O=C1NCCNCCCc2cc(ccn2)-c2nc(cs2)C(=O)Nc2cn(nc12)C1CCOCC1
Show InChI InChI=1S/C23H27N7O3S/c31-21-19-14-34-23(28-19)15-3-7-25-16(12-15)2-1-6-24-8-9-26-22(32)20-18(27-21)13-30(29-20)17-4-10-33-11-5-17/h3,7,12-14,17,24H,1-2,4-6,8-11H2,(H,26,32)(H,27,31)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317396
PNG
(US9617282, Example 169)
Show SMILES CN1CCCc2cc(ccn2)-c2nc(cs2)C(=O)Nc2cn(nc2C(=O)NCC1)C1CCOCC1
Show InChI InChI=1S/C24H29N7O3S/c1-30-9-2-3-17-13-16(4-7-25-17)24-28-20(15-35-24)22(32)27-19-14-31(18-5-11-34-12-6-18)29-21(19)23(33)26-8-10-30/h4,7,13-15,18H,2-3,5-6,8-12H2,1H3,(H,26,33)(H,27,32)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317397
PNG
(US9617282, Example 170)
Show SMILES CC(=O)N1CCCc2cc(ccn2)-c2nc(cs2)C(=O)Nc2cn(nc2C(=O)NCC1)C1CCOCC1
Show InChI InChI=1S/C25H29N7O4S/c1-16(33)31-9-2-3-18-13-17(4-7-26-18)25-29-21(15-37-25)23(34)28-20-14-32(19-5-11-36-12-6-19)30-22(20)24(35)27-8-10-31/h4,7,13-15,19H,2-3,5-6,8-12H2,1H3,(H,27,35)(H,28,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317398
PNG
(US9617282, Example 171)
Show SMILES CC(C)(C)OC(=O)NCCC(=O)N1CCCc2cc(ccn2)-c2nc(cs2)C(=O)Nc2cn(nc2C(=O)NCC1)C1CCOCC1
Show InChI InChI=1S/C31H40N8O6S/c1-31(2,3)45-30(43)34-11-7-25(40)38-13-4-5-21-17-20(6-10-32-21)29-36-24(19-46-29)27(41)35-23-18-39(22-8-15-44-16-9-22)37-26(23)28(42)33-12-14-38/h6,10,17-19,22H,4-5,7-9,11-16H2,1-3H3,(H,33,42)(H,34,43)(H,35,41)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317399
PNG
(US9617282, Example 174)
Show SMILES CC(C)N1CCCc2cc(ccn2)-c2nc(cs2)C(=O)Nc2cn(nc2C(=O)NCC1)C1CCOCC1
Show InChI InChI=1S/C26H33N7O3S/c1-17(2)32-10-3-4-19-14-18(5-8-27-19)26-30-22(16-37-26)24(34)29-21-15-33(20-6-12-36-13-7-20)31-23(21)25(35)28-9-11-32/h5,8,14-17,20H,3-4,6-7,9-13H2,1-2H3,(H,28,35)(H,29,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317402
PNG
(US9617282, Example 177)
Show SMILES CN(C)CCC(=O)N1CCCc2cc(ccn2)-c2nc(cs2)C(=O)Nc2cn(nc2C(=O)NCC1)C1CCOCC1
Show InChI InChI=1S/C28H36N8O4S/c1-34(2)12-6-24(37)35-11-3-4-20-16-19(5-9-29-20)28-32-23(18-41-28)26(38)31-22-17-36(21-7-14-40-15-8-21)33-25(22)27(39)30-10-13-35/h5,9,16-18,21H,3-4,6-8,10-15H2,1-2H3,(H,30,39)(H,31,38)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317403
PNG
(US9617282, Example 178)
Show SMILES NCCC(=O)N1CCCc2cc(ccn2)-c2nc(cs2)C(=O)Nc2cn(nc2C(=O)NCC1)C1CCOCC1
Show InChI InChI=1S/C26H32N8O4S/c27-7-3-22(35)33-10-1-2-18-14-17(4-8-28-18)26-31-21(16-39-26)24(36)30-20-15-34(19-5-12-38-13-6-19)32-23(20)25(37)29-9-11-33/h4,8,14-16,19H,1-3,5-7,9-13,27H2,(H,29,37)(H,30,36)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317404
PNG
(US9617282, Example 179)
Show SMILES OC(=O)CCN1CCCc2cc(ccn2)-c2nc(cs2)C(=O)Nc2cn(nc2C(=O)NCC1)C1CCOCC1
Show InChI InChI=1S/C26H31N7O5S/c34-22(35)4-10-32-9-1-2-18-14-17(3-7-27-18)26-30-21(16-39-26)24(36)29-20-15-33(19-5-12-38-13-6-19)31-23(20)25(37)28-8-11-32/h3,7,14-16,19H,1-2,4-6,8-13H2,(H,28,37)(H,29,36)(H,34,35)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317405
PNG
(US9617282, Example 180)
Show SMILES CCOC(=O)CCN1CCCc2cc(ccn2)-c2nc(cs2)C(=O)Nc2cn(nc2C(=O)NCC1)C1CCOCC1
Show InChI InChI=1S/C28H35N7O5S/c1-2-40-24(36)6-12-34-11-3-4-20-16-19(5-9-29-20)28-32-23(18-41-28)26(37)31-22-17-35(21-7-14-39-15-8-21)33-25(22)27(38)30-10-13-34/h5,9,16-18,21H,2-4,6-8,10-15H2,1H3,(H,30,38)(H,31,37)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317406
PNG
(US9617282, Example 181)
Show SMILES NC(=O)CCN1CCCc2cc(ccn2)-c2nc(cs2)C(=O)Nc2cn(nc2C(=O)NCC1)C1CCOCC1
Show InChI InChI=1S/C26H32N8O4S/c27-22(35)4-10-33-9-1-2-18-14-17(3-7-28-18)26-31-21(16-39-26)24(36)30-20-15-34(19-5-12-38-13-6-19)32-23(20)25(37)29-8-11-33/h3,7,14-16,19H,1-2,4-6,8-13H2,(H2,27,35)(H,29,37)(H,30,36)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317408
PNG
(US9617282, Example 183)
Show SMILES CCC(=O)N1CCCc2cc(ccn2)-c2nc(cs2)C(=O)Nc2cn(nc2C(=O)NCC1)C1CCOCC1
Show InChI InChI=1S/C26H31N7O4S/c1-2-22(34)32-10-3-4-18-14-17(5-8-27-18)26-30-21(16-38-26)24(35)29-20-15-33(19-6-12-37-13-7-19)31-23(20)25(36)28-9-11-32/h5,8,14-16,19H,2-4,6-7,9-13H2,1H3,(H,28,36)(H,29,35)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317409
PNG
(US9617282, Example 184)
Show SMILES O=C(C1CC1)N1CCCc2cc(ccn2)-c2nc(cs2)C(=O)Nc2cn(nc2C(=O)NCC1)C1CCOCC1
Show InChI InChI=1S/C27H31N7O4S/c35-24-22-16-39-26(31-22)18-5-8-28-19(14-18)2-1-10-33(27(37)17-3-4-17)11-9-29-25(36)23-21(30-24)15-34(32-23)20-6-12-38-13-7-20/h5,8,14-17,20H,1-4,6-7,9-13H2,(H,29,36)(H,30,35)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317410
PNG
(US9617282, Example 185)
Show SMILES CC(C)(CO)C(=O)N1CCCc2cc(ccn2)-c2nc(cs2)C(=O)Nc2cn(nc2C(=O)NCC1)C1CCOCC1
Show InChI InChI=1S/C28H35N7O5S/c1-28(2,17-36)27(39)34-10-3-4-19-14-18(5-8-29-19)26-32-22(16-41-26)24(37)31-21-15-35(20-6-12-40-13-7-20)33-23(21)25(38)30-9-11-34/h5,8,14-16,20,36H,3-4,6-7,9-13,17H2,1-2H3,(H,30,38)(H,31,37)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317411
PNG
(US9617282, Example 186)
Show SMILES CNC(=O)N1CCCc2cc(ccn2)-c2nc(cs2)C(=O)Nc2cn(nc2C(=O)NCC1)C1CCOCC1
Show InChI InChI=1S/C25H30N8O4S/c1-26-25(36)32-9-2-3-17-13-16(4-7-27-17)24-30-20(15-38-24)22(34)29-19-14-33(18-5-11-37-12-6-18)31-21(19)23(35)28-8-10-32/h4,7,13-15,18H,2-3,5-6,8-12H2,1H3,(H,26,36)(H,28,35)(H,29,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317413
PNG
(US9617282, Example 188)
Show SMILES OCCC(=O)N1CCCc2cc(ccn2)-c2nc(cs2)C(=O)Nc2cn(nc2C(=O)NCC1)C1CCOCC1
Show InChI InChI=1S/C26H31N7O5S/c34-11-4-22(35)32-9-1-2-18-14-17(3-7-27-18)26-30-21(16-39-26)24(36)29-20-15-33(19-5-12-38-13-6-19)31-23(20)25(37)28-8-10-32/h3,7,14-16,19,34H,1-2,4-6,8-13H2,(H,28,37)(H,29,36)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317414
PNG
(US9617282, Example 189)
Show SMILES CCOC(=O)CC(=O)N1CCCc2cc(ccn2)-c2nc(cs2)C(=O)Nc2cn(nc2C(=O)NCC1)C1CCOCC1
Show InChI InChI=1S/C28H33N7O6S/c1-2-41-24(37)15-23(36)34-10-3-4-19-14-18(5-8-29-19)28-32-22(17-42-28)26(38)31-21-16-35(20-6-12-40-13-7-20)33-25(21)27(39)30-9-11-34/h5,8,14,16-17,20H,2-4,6-7,9-13,15H2,1H3,(H,30,39)(H,31,38)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317415
PNG
(US9617282, Example 190)
Show SMILES O=C(C1CCOCC1)N1CCCc2cc(ccn2)-c2nc(cs2)C(=O)Nc2cn(nc2C(=O)NCC1)C1CCOCC1
Show InChI InChI=1S/C29H35N7O5S/c37-26-24-18-42-28(33-24)20-3-8-30-21(16-20)2-1-10-35(29(39)19-4-12-40-13-5-19)11-9-31-27(38)25-23(32-26)17-36(34-25)22-6-14-41-15-7-22/h3,8,16-19,22H,1-2,4-7,9-15H2,(H,31,38)(H,32,37)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317416
PNG
(US9617282, Example 191)
Show SMILES CCNC(=O)N1CCCc2cc(ccn2)-c2nc(cs2)C(=O)Nc2cn(nc2C(=O)NCC1)C1CCOCC1
Show InChI InChI=1S/C26H32N8O4S/c1-2-27-26(37)33-10-3-4-18-14-17(5-8-28-18)25-31-21(16-39-25)23(35)30-20-15-34(19-6-12-38-13-7-19)32-22(20)24(36)29-9-11-33/h5,8,14-16,19H,2-4,6-7,9-13H2,1H3,(H,27,37)(H,29,36)(H,30,35)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317421
PNG
(US9617282, Example 196)
Show SMILES O=C1CNC(=O)c2nn(cc2NC(=O)c2csc(n2)-c2ccnc(CCCN1)c2)C1CCOCC1
Show InChI InChI=1S/C23H25N7O4S/c31-19-11-26-22(33)20-17(12-30(29-20)16-4-8-34-9-5-16)27-21(32)18-13-35-23(28-18)14-3-7-24-15(10-14)2-1-6-25-19/h3,7,10,12-13,16H,1-2,4-6,8-9,11H2,(H,25,31)(H,26,33)(H,27,32)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317425
PNG
(US9617282, Example 200)
Show SMILES O=C1CC2NC(=O)c3nn(cc3NC(=O)c3csc(n3)-c3ccnc(CCCN1C2=O)c3)C1CCOCC1
Show InChI InChI=1S/C25H25N7O5S/c33-20-11-17-25(36)31(20)7-1-2-15-10-14(3-6-26-15)24-29-19(13-38-24)22(34)28-18-12-32(16-4-8-37-9-5-16)30-21(18)23(35)27-17/h3,6,10,12-13,16-17H,1-2,4-5,7-9,11H2,(H,27,35)(H,28,34)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317428
PNG
(US9617282, Example 203)
Show SMILES Cn1cc2NC(=O)c3cccc(n3)-c3ccnc(OCCOCCNC(=O)c2n1)c3
Show InChI InChI=1S/C20H20N6O4/c1-26-12-16-18(25-26)20(28)22-7-8-29-9-10-30-17-11-13(5-6-21-17)14-3-2-4-15(23-14)19(27)24-16/h2-6,11-12H,7-10H2,1H3,(H,22,28)(H,24,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317432
PNG
(US9617282, Example 207)
Show SMILES Cn1cc2NC(=O)c3csc(c3)-c3ccnc(OCCOCCNC(=O)c2n1)c3
Show InChI InChI=1S/C19H19N5O4S/c1-24-10-14-17(23-24)19(26)21-4-5-27-6-7-28-16-9-12(2-3-20-16)15-8-13(11-29-15)18(25)22-14/h2-3,8-11H,4-7H2,1H3,(H,21,26)(H,22,25)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317434
PNG
(US9617282, Example 210)
Show SMILES O=C1NCCOCCOc2cc(ccn2)-c2cccc(c2)C(=O)Nc2cn(nc12)C1CCOCC1
Show InChI InChI=1S/C25H27N5O5/c31-24-19-3-1-2-17(14-19)18-4-7-26-22(15-18)35-13-12-34-11-8-27-25(32)23-21(28-24)16-30(29-23)20-5-9-33-10-6-20/h1-4,7,14-16,20H,5-6,8-13H2,(H,27,32)(H,28,31)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317439
PNG
(US9617282, Example 215)
Show SMILES Cn1cc2NC(=O)c3csc(n3)-c3ccnc(CCCOCCCNC(=O)c2n1)c3
Show InChI InChI=1S/C20H22N6O3S/c1-26-11-15-17(25-26)19(28)22-6-3-9-29-8-2-4-14-10-13(5-7-21-14)20-24-16(12-30-20)18(27)23-15/h5,7,10-12H,2-4,6,8-9H2,1H3,(H,22,28)(H,23,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317440
PNG
(US9617282, Example 216)
Show SMILES O=C1NCCCOCCCc2cc(ccn2)-c2nc(cs2)C(=O)Nc2cn(nc12)C1CCOCC1
Show InChI InChI=1S/C24H28N6O4S/c31-22-20-15-35-24(28-20)16-4-8-25-17(13-16)3-1-9-33-10-2-7-26-23(32)21-19(27-22)14-30(29-21)18-5-11-34-12-6-18/h4,8,13-15,18H,1-3,5-7,9-12H2,(H,26,32)(H,27,31)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317441
PNG
(US9617282, Example 217)
Show SMILES Cn1cc2NC(=O)c3csc(n3)-c3ccnc(CCCCOCCNC(=O)c2n1)c3
Show InChI InChI=1S/C20H22N6O3S/c1-26-11-15-17(25-26)19(28)22-7-9-29-8-3-2-4-14-10-13(5-6-21-14)20-24-16(12-30-20)18(27)23-15/h5-6,10-12H,2-4,7-9H2,1H3,(H,22,28)(H,23,27)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317442
PNG
(US9617282, Example 218)
Show SMILES O=C1NCCOCCCCc2cc(ccn2)-c2nc(cs2)C(=O)Nc2cn(nc12)C1CCOCC1
Show InChI InChI=1S/C24H28N6O4S/c31-22-20-15-35-24(28-20)16-4-7-25-17(13-16)3-1-2-9-33-12-8-26-23(32)21-19(27-22)14-30(29-21)18-5-10-34-11-6-18/h4,7,13-15,18H,1-3,5-6,8-12H2,(H,26,32)(H,27,31)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM317443
PNG
(US9617282, Example 219)
Show SMILES CN1CCOCCNC(=O)c2nn(cc2NC(=O)c2csc(n2)-c2ccnc1c2)C1CCOCC1
Show InChI InChI=1S/C23H27N7O4S/c1-29-7-11-34-10-6-25-22(32)20-17(13-30(28-20)16-3-8-33-9-4-16)26-21(31)18-14-35-23(27-18)15-2-5-24-19(29)12-15/h2,5,12-14,16H,3-4,6-11H2,1H3,(H,25,32)(H,26,31)
PDB
MMDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a<100n/an/an/an/an/an/a



BIOGEN MA INC.

US Patent


Assay Description
The biochemical assay is in a AlphaScreen format. The kinase reaction is based on the IRAK-4 phosphorylation of a biotin labeled peptide. The phospho...


US Patent US9617282 (2017)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 218 total )  |  Next  |  Last  >>
Jump to: