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Found 292 Enz. Inhib. hit(s) with all data for entry = 6411
LigandPNGBDBM127387(US8791131, 149)
Affinity DataKi:  0.102nM ΔG°:  -57.0kJ/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM127481(US8791131, 258)
Affinity DataKi:  0.110nM ΔG°:  -56.8kJ/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM127483(US8791131, 261)
Affinity DataKi:  0.114nM ΔG°:  -56.8kJ/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM127490(US8791131, 268)
Affinity DataKi:  0.117nM ΔG°:  -56.7kJ/molepH: 7.5 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM127489(US8791131, 267)
Affinity DataKi:  0.145nM ΔG°:  -56.2kJ/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM127482(US8791131, 260)
Affinity DataKi:  0.167nM ΔG°:  -55.8kJ/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50428109(CHEMBL2331668 | US8791131, 259)
Affinity DataKi:  0.191nM ΔG°:  -55.5kJ/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM127403(US8791131, 168)
Affinity DataKi:  0.204nM ΔG°:  -55.3kJ/molepH: 7.5 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM127481(US8791131, 258)
Affinity DataKi:  0.241nM ΔG°:  -54.9kJ/molepH: 7.5 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM50428109(CHEMBL2331668 | US8791131, 259)
Affinity DataKi:  0.243nM ΔG°:  -54.9kJ/molepH: 7.5 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM127468(US8791131, 242)
Affinity DataKi:  0.252nM ΔG°:  -54.8kJ/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM127435(US8791131, 209)
Affinity DataKi:  0.264nM ΔG°:  -54.7kJ/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM127455(US8791131, 229)
Affinity DataKi:  0.273nM ΔG°:  -54.6kJ/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM127431(US8791131, 205)
Affinity DataKi:  0.281nM ΔG°:  -54.5kJ/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM127485(US8791131, 263)
Affinity DataKi:  0.282nM ΔG°:  -54.5kJ/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM127430(US8791131, 204)
Affinity DataKi:  0.298nM ΔG°:  -54.4kJ/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM127468(US8791131, 242)
Affinity DataKi:  0.299nM ΔG°:  -54.4kJ/molepH: 7.5 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM127411(US8791131, 180)
Affinity DataKi:  0.320nM ΔG°:  -54.2kJ/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM127484(US8791131, 262)
Affinity DataKi:  0.320nM ΔG°:  -54.2kJ/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM127482(US8791131, 260)
Affinity DataKi:  0.323nM ΔG°:  -54.2kJ/molepH: 7.5 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM127455(US8791131, 229)
Affinity DataKi:  0.330nM ΔG°:  -54.1kJ/molepH: 7.5 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM127377(US8791131, 139)
Affinity DataKi:  0.339nM ΔG°:  -54.1kJ/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM127489(US8791131, 267)
Affinity DataKi:  0.359nM ΔG°:  -53.9kJ/molepH: 7.5 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM127490(US8791131, 268)
Affinity DataKi:  0.366nM ΔG°:  -53.9kJ/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM50428111(CHEMBL2331666 | US8791131, 153)
Affinity DataKi:  0.377nM ΔG°:  -53.8kJ/molepH: 7.5 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM127421(US8791131, 195)
Affinity DataKi:  0.391nM ΔG°:  -53.7kJ/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM127440(US8791131, 214)
Affinity DataKi:  0.397nM ΔG°:  -53.7kJ/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM127462(US8791131, 236)
Affinity DataKi:  0.404nM ΔG°:  -53.6kJ/molepH: 7.5 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM127464(US8791131, 238)
Affinity DataKi:  0.438nM ΔG°:  -53.4kJ/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM127423(US8791131, 197)
Affinity DataKi:  0.444nM ΔG°:  -53.4kJ/molepH: 7.5 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50428115(CHEMBL2331661 | US8791131, 136)
Affinity DataKi:  0.478nM ΔG°:  -53.2kJ/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50428119(CHEMBL2331658 | US8791131, 133)
Affinity DataKi:  0.5nM ΔG°:  -53.1kJ/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM127419(US8791131, 191)
Affinity DataKi:  0.5nM ΔG°:  -53.1kJ/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50428118(CHEMBL2331659 | US8791131, 134)
Affinity DataKi:  0.5nM ΔG°:  -53.1kJ/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM127442(US8791131, 216)
Affinity DataKi:  0.505nM ΔG°:  -53.1kJ/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM127374(US8791131, 132)
Affinity DataKi:  0.510nM ΔG°:  -53.0kJ/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50428110(CHEMBL2331667 | US8791131, 254)
Affinity DataKi:  0.513nM ΔG°:  -53.0kJ/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM127436(US8791131, 210)
Affinity DataKi:  0.529nM ΔG°:  -52.9kJ/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50428113(CHEMBL2331663 | US8791131, 172)
Affinity DataKi:  0.532nM ΔG°:  -52.9kJ/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM127363(US8791131, 121)
Affinity DataKi:  0.539nM ΔG°:  -52.9kJ/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM127381(US8791131, 143)
Affinity DataKi:  0.568nM ΔG°:  -52.8kJ/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM127480(US8791131, 256)
Affinity DataKi:  0.575nM ΔG°:  -52.7kJ/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM127373(US8791131, 131)
Affinity DataKi:  0.644nM ΔG°:  -52.5kJ/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM127483(US8791131, 261)
Affinity DataKi:  0.658nM ΔG°:  -52.4kJ/molepH: 7.5 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against mTOR using an in vitro kinase assay. mTOR activity is measured in vitro by dete...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM127378(US8791131, 140)
Affinity DataKi:  0.668nM ΔG°:  -52.4kJ/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50428108(CHEMBL2331669 | US8791131, 255)
Affinity DataKi:  0.721nM ΔG°:  -52.2kJ/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM127422(US8791131, 196)
Affinity DataKi:  0.760nM ΔG°:  -52.0kJ/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM127432(US8791131, 206)
Affinity DataKi:  0.802nM ΔG°:  -51.9kJ/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM127364(US8791131, 122)
Affinity DataKi:  0.806nM ΔG°:  -51.9kJ/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM127477(US8791131, 251)
Affinity DataKi:  0.811nM ΔG°:  -51.9kJ/molepH: 7.4 T: 2°CAssay Description:Compounds of the present invention were evaluated for potency against PI3-Kalpha using an in vitro kinase assay. PI3-Kalpha activity is measured in v...More data for this Ligand-Target Pair
In DepthDetails US Patent
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