Compile Data Set for Download or QSAR

Found 64 hits Enz. Inhib. hit(s) with all data for entry = 1912   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein kinase B (Akt 1) (Homo sapiens (Human))	BDBM15067 ((2S)-1-(1H-indol-3-yl)-3-(5-isoquinolin-6-ylpyridi...) Show SMILES N[C@H](COc1cncc(c1)-c1ccc2cnccc2c1)Cc1c[nH]c2ccccc12 Show InChI InChI=1S/C25H22N4O/c26-22(10-21-14-29-25-4-2-1-3-24(21)25)16-30-23-11-20(13-28-15-23)17-5-6-19-12-27-8-7-18(19)9-17/h1-9,11-15,22,29H,10,16,26H2/t22-/m0/s1	PDB MMDB B.MOAD GoogleScholar	MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair
Protein kinase B (Akt 1) (Homo sapiens (Human))	BDBM2579 ((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...) Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1	PDB MMDB B.MOAD GoogleScholar	Purchase CHEBI CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	1.5	n/a	n/a	n/a	n/a	7.5	22
Abbott Laboratories					Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA) (Bos taurus (bovine))	BDBM15067 ((2S)-1-(1H-indol-3-yl)-3-(5-isoquinolin-6-ylpyridi...) Show SMILES N[C@H](COc1cncc(c1)-c1ccc2cnccc2c1)Cc1c[nH]c2ccccc12 Show InChI InChI=1S/C25H22N4O/c26-22(10-21-14-29-25-4-2-1-3-24(21)25)16-30-23-11-20(13-28-15-23)17-5-6-19-12-27-8-7-18(19)9-17/h1-9,11-15,22,29H,10,16,26H2/t22-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar	MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The kinase assay uses purified recombinant enzyme and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidi...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP-Dependent Protein Kinase (PKA) (Bos taurus (bovine))	BDBM2579 ((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...) Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1	PDB UniProtKB/SwissProt GoogleScholar	Purchase CHEBI CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	3.60	n/a	n/a	n/a	n/a	7.4	22
Abbott Laboratories					Assay Description The kinase assay uses purified recombinant enzyme and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidi...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine/threonine-protein kinase AKT2 (Homo sapiens (Human))	BDBM2579 ((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...) Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	Purchase CHEBI CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	6.5	n/a	n/a	n/a	n/a	7.5	22
Abbott Laboratories					Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair
Protein kinase C, gamma (Homo sapiens (Human))	BDBM2579 ((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...) Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase CHEBI CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	6.60	n/a	n/a	n/a	n/a	7.4	22
Abbott Laboratories					Assay Description The kinase assay uses purified recombinant enzyme and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidi...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase AKT2 (Homo sapiens (Human))	BDBM15067 ((2S)-1-(1H-indol-3-yl)-3-(5-isoquinolin-6-ylpyridi...) Show SMILES N[C@H](COc1cncc(c1)-c1ccc2cnccc2c1)Cc1c[nH]c2ccccc12 Show InChI InChI=1S/C25H22N4O/c26-22(10-21-14-29-25-4-2-1-3-24(21)25)16-30-23-11-20(13-28-15-23)17-5-6-19-12-27-8-7-18(19)9-17/h1-9,11-15,22,29H,10,16,26H2/t22-/m0/s1	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	6.80	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase AKT (Homo sapiens (Human))	BDBM2579 ((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...) Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	Purchase CHEBI CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	7.5	22
Abbott Laboratories					Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair
Protein kinase B (Akt 1) (Homo sapiens (Human))	BDBM15022 (3-[(2S)-2-amino-3-({5-[(E)-2-(pyridin-4-yl)ethenyl...) Show SMILES N[C@H](COc1cncc(\C=C\c2ccncc2)c1)Cc1c[nH]c2ccccc12 Show InChI InChI=1S/C23H22N4O/c24-20(12-19-14-27-23-4-2-1-3-22(19)23)16-28-21-11-18(13-26-15-21)6-5-17-7-9-25-10-8-17/h1-11,13-15,20,27H,12,16,24H2/b6-5+/t20-/m0/s1	PDB MMDB B.MOAD GoogleScholar	DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	7.5	22
Abbott Laboratories					Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair
Protein kinase B (Akt 1) (Homo sapiens (Human))	BDBM15068 (13b (R-) | 6-{5-[(2R)-2-amino-3-(1H-indol-3-yl)pro...) Show SMILES N[C@@H](COc1cncc(c1)-c1ccc2cnccc2c1)Cc1c[nH]c2ccccc12 Show InChI InChI=1S/C25H22N4O/c26-22(10-21-14-29-25-4-2-1-3-24(21)25)16-30-23-11-20(13-28-15-23)17-5-6-19-12-27-8-7-18(19)9-17/h1-9,11-15,22,29H,10,16,26H2/t22-/m1/s1	PDB MMDB B.MOAD GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	26	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase AKT (Homo sapiens (Human))	BDBM15067 ((2S)-1-(1H-indol-3-yl)-3-(5-isoquinolin-6-ylpyridi...) Show SMILES N[C@H](COc1cncc(c1)-c1ccc2cnccc2c1)Cc1c[nH]c2ccccc12 Show InChI InChI=1S/C25H22N4O/c26-22(10-21-14-29-25-4-2-1-3-24(21)25)16-30-23-11-20(13-28-15-23)17-5-6-19-12-27-8-7-18(19)9-17/h1-9,11-15,22,29H,10,16,26H2/t22-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	35	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair
cAMP-Dependent Protein Kinase (PKA) (Bos taurus (bovine))	BDBM15022 (3-[(2S)-2-amino-3-({5-[(E)-2-(pyridin-4-yl)ethenyl...) Show SMILES N[C@H](COc1cncc(\C=C\c2ccncc2)c1)Cc1c[nH]c2ccccc12 Show InChI InChI=1S/C23H22N4O/c24-20(12-19-14-27-23-4-2-1-3-22(19)23)16-28-21-11-18(13-26-15-21)6-5-17-7-9-25-10-8-17/h1-11,13-15,20,27H,12,16,24H2/b6-5+/t20-/m0/s1	PDB UniProtKB/SwissProt GoogleScholar	DrugBank MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	38	n/a	n/a	n/a	n/a	7.4	22
Abbott Laboratories					Assay Description The kinase assay uses purified recombinant enzyme and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidi...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein kinase B (Akt 1) (Homo sapiens (Human))	BDBM15066 (5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]-2-(pyrid...) Show SMILES N[C@H](COc1cncc2nc(ccc12)-c1ccncc1)Cc1c[nH]c2ccccc12 Show InChI InChI=1S/C24H21N5O/c25-18(11-17-12-28-22-4-2-1-3-19(17)22)15-30-24-14-27-13-23-20(24)5-6-21(29-23)16-7-9-26-10-8-16/h1-10,12-14,18,28H,11,15,25H2/t18-/m0/s1	PDB MMDB B.MOAD GoogleScholar	DrugBank MMDB PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair
Protein kinase B (Akt 1) (Homo sapiens (Human))	BDBM15064 (N-[(2S)-2-amino-3-(1H-indol-3-yl)propyl]-5-(isoqui...) Show SMILES N[C@H](CNc1cncc(Oc2cccc3cnccc23)c1)Cc1c[nH]c2ccccc12 Show InChI InChI=1S/C25H23N5O/c26-19(10-18-13-30-24-6-2-1-5-22(18)24)14-29-20-11-21(16-28-15-20)31-25-7-3-4-17-12-27-9-8-23(17)25/h1-9,11-13,15-16,19,29-30H,10,14,26H2/t19-/m0/s1	PDB MMDB B.MOAD GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	210	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair
Protein kinase B (Akt 1) (Homo sapiens (Human))	BDBM15023 (3-[(2S)-2-amino-3-({5-[2-(pyridin-4-yl)ethynyl]pyr...) Show SMILES N[C@H](COc1cncc(c1)C#Cc1ccncc1)Cc1c[nH]c2ccccc12 Show InChI InChI=1S/C23H20N4O/c24-20(12-19-14-27-23-4-2-1-3-22(19)23)16-28-21-11-18(13-26-15-21)6-5-17-7-9-25-10-8-17/h1-4,7-11,13-15,20,27H,12,16,24H2/t20-/m0/s1	PDB MMDB B.MOAD GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	210	n/a	n/a	n/a	n/a	7.5	22
Abbott Laboratories					Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair
Protein kinase B (Akt 1) (Homo sapiens (Human))	BDBM15050 (N-(4-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyr...) Show SMILES CC(=O)Nc1ccc(cc1)-c1cncc(OC[C@@H](N)Cc2c[nH]c3ccccc23)c1 Show InChI InChI=1S/C24H24N4O2/c1-16(29)28-21-8-6-17(7-9-21)18-11-22(14-26-12-18)30-15-20(25)10-19-13-27-24-5-3-2-4-23(19)24/h2-9,11-14,20,27H,10,15,25H2,1H3,(H,28,29)/t20-/m0/s1	PDB MMDB B.MOAD GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	227	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase AKT2 (Homo sapiens (Human))	BDBM15022 (3-[(2S)-2-amino-3-({5-[(E)-2-(pyridin-4-yl)ethenyl...) Show SMILES N[C@H](COc1cncc(\C=C\c2ccncc2)c1)Cc1c[nH]c2ccccc12 Show InChI InChI=1S/C23H22N4O/c24-20(12-19-14-27-23-4-2-1-3-22(19)23)16-28-21-11-18(13-26-15-21)6-5-17-7-9-25-10-8-17/h1-11,13-15,20,27H,12,16,24H2/b6-5+/t20-/m0/s1	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	257	n/a	n/a	n/a	n/a	7.5	22
Abbott Laboratories					Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair
Protein kinase B (Akt 1) (Homo sapiens (Human))	BDBM15037 (3-[(2S)-2-amino-3-{[5-(pyridin-4-yl)pyridin-3-yl]o...) Show SMILES N[C@H](COc1cncc(c1)-c1ccncc1)Cc1c[nH]c2ccccc12 Show InChI InChI=1S/C21H20N4O/c22-18(9-17-12-25-21-4-2-1-3-20(17)21)14-26-19-10-16(11-24-13-19)15-5-7-23-8-6-15/h1-8,10-13,18,25H,9,14,22H2/t18-/m0/s1	PDB MMDB B.MOAD GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair
Protein kinase C, gamma (Homo sapiens (Human))	BDBM15067 ((2S)-1-(1H-indol-3-yl)-3-(5-isoquinolin-6-ylpyridi...) Show SMILES N[C@H](COc1cncc(c1)-c1ccc2cnccc2c1)Cc1c[nH]c2ccccc12 Show InChI InChI=1S/C25H22N4O/c26-22(10-21-14-29-25-4-2-1-3-24(21)25)16-30-23-11-20(13-28-15-23)17-5-6-19-12-27-8-7-18(19)9-17/h1-9,11-15,22,29H,10,16,26H2/t22-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	270	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The kinase assay uses purified recombinant enzyme and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidi...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair
Protein kinase B (Akt 1) (Homo sapiens (Human))	BDBM15065 (3-N-[(2S)-2-amino-3-(1H-indol-3-yl)propyl]-5-N-(is...) Show SMILES N[C@H](CNc1cncc(Nc2cccc3cnccc23)c1)Cc1c[nH]c2ccccc12 Show InChI InChI=1S/C25H24N6/c26-19(10-18-13-30-24-6-2-1-5-22(18)24)14-29-20-11-21(16-28-15-20)31-25-7-3-4-17-12-27-9-8-23(17)25/h1-9,11-13,15-16,19,29-31H,10,14,26H2/t19-/m0/s1	PDB MMDB B.MOAD GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	270	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair
Protein kinase B (Akt 1) (Homo sapiens (Human))	BDBM15062 (3-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]-6-(pyrid...) Show SMILES N[C@H](COc1cnc2ccc(cc2c1)-c1ccncc1)Cc1c[nH]c2ccccc12 Show InChI InChI=1S/C25H22N4O/c26-21(12-20-14-28-25-4-2-1-3-23(20)25)16-30-22-13-19-11-18(5-6-24(19)29-15-22)17-7-9-27-10-8-17/h1-11,13-15,21,28H,12,16,26H2/t21-/m0/s1	PDB MMDB B.MOAD GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase AKT (Homo sapiens (Human))	BDBM15022 (3-[(2S)-2-amino-3-({5-[(E)-2-(pyridin-4-yl)ethenyl...) Show SMILES N[C@H](COc1cncc(\C=C\c2ccncc2)c1)Cc1c[nH]c2ccccc12 Show InChI InChI=1S/C23H22N4O/c24-20(12-19-14-27-23-4-2-1-3-22(19)23)16-28-21-11-18(13-26-15-21)6-5-17-7-9-25-10-8-17/h1-11,13-15,20,27H,12,16,24H2/b6-5+/t20-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar	DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	354	n/a	n/a	n/a	n/a	7.5	22
Abbott Laboratories					Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair
Protein kinase C (PKC) (Homo sapiens (Human))	BDBM2579 ((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...) Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13 Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase CHEBI CHEMBL KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	570	n/a	n/a	n/a	n/a	7.4	22
Abbott Laboratories					Assay Description The kinase assay uses purified recombinant enzyme and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidi...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair
Protein kinase B (Akt 1) (Homo sapiens (Human))	BDBM15021 (3-[(2S)-2-amino-3-phenylpropoxy]-5-[(E)-2-(pyridin...) Show SMILES N[C@H](COc1cncc(\C=C\c2ccncc2)c1)Cc1ccccc1 Show InChI InChI=1S/C21H21N3O/c22-20(12-18-4-2-1-3-5-18)16-25-21-13-19(14-24-15-21)7-6-17-8-10-23-11-9-17/h1-11,13-15,20H,12,16,22H2/b7-6+/t20-/m0/s1	PDB MMDB B.MOAD GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	690	n/a	n/a	n/a	n/a	7.5	22
Abbott Laboratories					Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair
Protein kinase C (PKC) (Homo sapiens (Human))	BDBM15022 (3-[(2S)-2-amino-3-({5-[(E)-2-(pyridin-4-yl)ethenyl...) Show SMILES N[C@H](COc1cncc(\C=C\c2ccncc2)c1)Cc1c[nH]c2ccccc12 Show InChI InChI=1S/C23H22N4O/c24-20(12-19-14-27-23-4-2-1-3-22(19)23)16-28-21-11-18(13-26-15-21)6-5-17-7-9-25-10-8-17/h1-11,13-15,20,27H,12,16,24H2/b6-5+/t20-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	930	n/a	n/a	n/a	n/a	7.4	22
Abbott Laboratories					Assay Description The kinase assay uses purified recombinant enzyme and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidi...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair
Protein kinase B (Akt 1) (Homo sapiens (Human))	BDBM15055 (3-(5-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyr...) Show SMILES N[C@H](COc1cncc(c1)-c1ccc(NC(=O)Nc2ccccc2)nc1)Cc1c[nH]c2ccccc12 Show InChI InChI=1S/C28H26N6O2/c29-22(12-21-16-31-26-9-5-4-8-25(21)26)18-36-24-13-20(14-30-17-24)19-10-11-27(32-15-19)34-28(35)33-23-6-2-1-3-7-23/h1-11,13-17,22,31H,12,18,29H2,(H2,32,33,34,35)/t22-/m0/s1	PDB MMDB B.MOAD GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.12E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair
Protein kinase C, gamma (Homo sapiens (Human))	BDBM15022 (3-[(2S)-2-amino-3-({5-[(E)-2-(pyridin-4-yl)ethenyl...) Show SMILES N[C@H](COc1cncc(\C=C\c2ccncc2)c1)Cc1c[nH]c2ccccc12 Show InChI InChI=1S/C23H22N4O/c24-20(12-19-14-27-23-4-2-1-3-22(19)23)16-28-21-11-18(13-26-15-21)6-5-17-7-9-25-10-8-17/h1-11,13-15,20,27H,12,16,24H2/b6-5+/t20-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	7.4	22
Abbott Laboratories					Assay Description The kinase assay uses purified recombinant enzyme and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidi...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair
Protein kinase B (Akt 1) (Homo sapiens (Human))	BDBM15038 (5-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridi...) Show SMILES Cc1c(cc(C#N)c(=O)n1C)-c1cncc(OC[C@@H](N)Cc2c[nH]c3ccccc23)c1 Show InChI InChI=1S/C24H23N5O2/c1-15-22(9-16(10-25)24(30)29(15)2)18-8-20(13-27-11-18)31-14-19(26)7-17-12-28-23-6-4-3-5-21(17)23/h3-6,8-9,11-13,19,28H,7,14,26H2,1-2H3/t19-/m0/s1	PDB MMDB B.MOAD GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.34E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair
Protein kinase B (Akt 1) (Homo sapiens (Human))	BDBM15049 (2-(3-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyr...) Show SMILES N[C@H](COc1cncc(c1)-c1cccc(CC(N)=O)c1)Cc1c[nH]c2ccccc12 Show InChI InChI=1S/C24H24N4O2/c25-20(10-19-13-28-23-7-2-1-6-22(19)23)15-30-21-11-18(12-27-14-21)17-5-3-4-16(8-17)9-24(26)29/h1-8,11-14,20,28H,9-10,15,25H2,(H2,26,29)/t20-/m0/s1	PDB MMDB B.MOAD GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.39E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair
Protein kinase B (Akt 1) (Homo sapiens (Human))	BDBM15060 (4-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridi...) Show SMILES N[C@H](COc1cncc(c1)-c1ccc(N)c(c1)C(=O)c1cccc(Cl)c1)Cc1c[nH]c2ccccc12 Show InChI InChI=1S/C29H25ClN4O2/c30-22-5-3-4-19(10-22)29(35)26-13-18(8-9-27(26)32)20-12-24(16-33-14-20)36-17-23(31)11-21-15-34-28-7-2-1-6-25(21)28/h1-10,12-16,23,34H,11,17,31-32H2/t23-/m0/s1	PDB MMDB B.MOAD GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.45E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair
Protein kinase B (Akt 1) (Homo sapiens (Human))	BDBM15040 (3-[(2S)-2-amino-3-{[5-(4-fluorophenyl)pyridin-3-yl...) Show SMILES N[C@H](COc1cncc(c1)-c1ccc(F)cc1)Cc1c[nH]c2ccccc12 Show InChI InChI=1S/C22H20FN3O/c23-18-7-5-15(6-8-18)16-10-20(13-25-11-16)27-14-19(24)9-17-12-26-22-4-2-1-3-21(17)22/h1-8,10-13,19,26H,9,14,24H2/t19-/m0/s1	PDB MMDB B.MOAD GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.56E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair
Protein kinase B (Akt 1) (Homo sapiens (Human))	BDBM15039 (4-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridi...) Show SMILES N[C@H](COc1cncc(c1)-c1ccc(cc1)C#N)Cc1c[nH]c2ccccc12 Show InChI InChI=1S/C23H20N4O/c24-11-16-5-7-17(8-6-16)18-10-21(14-26-12-18)28-15-20(25)9-19-13-27-23-4-2-1-3-22(19)23/h1-8,10,12-14,20,27H,9,15,25H2/t20-/m0/s1	PDB MMDB B.MOAD GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.83E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair
Protein kinase B (Akt 1) (Homo sapiens (Human))	BDBM15025 (5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]-N-(pyrid...) Show SMILES N[C@H](COc1cncc(c1)C(=O)Nc1ccncc1)Cc1c[nH]c2ccccc12 Show InChI InChI=1S/C22H21N5O2/c23-17(9-15-12-26-21-4-2-1-3-20(15)21)14-29-19-10-16(11-25-13-19)22(28)27-18-5-7-24-8-6-18/h1-8,10-13,17,26H,9,14,23H2,(H,24,27,28)/t17-/m0/s1	PDB MMDB B.MOAD GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.02E+3	n/a	n/a	n/a	n/a	7.5	22
Abbott Laboratories					Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair
Protein kinase B (Akt 1) (Homo sapiens (Human))	BDBM15033 (5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]-N-(pyrid...) Show SMILES N[C@H](COc1cncc(Nc2cccnc2)c1)Cc1c[nH]c2ccccc12 Show InChI InChI=1S/C21H21N5O/c22-16(8-15-10-25-21-6-2-1-5-20(15)21)14-27-19-9-18(12-24-13-19)26-17-4-3-7-23-11-17/h1-7,9-13,16,25-26H,8,14,22H2/t16-/m0/s1	PDB MMDB B.MOAD GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.16E+3	n/a	n/a	n/a	n/a	7.5	22
Abbott Laboratories					Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair
Protein kinase B (Akt 1) (Homo sapiens (Human))	BDBM15061 (5-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridi...) Show SMILES N[C@H](COc1cncc(c1)-c1cccc2c(cccc12)C(N)=O)Cc1c[nH]c2ccccc12 Show InChI InChI=1S/C27H24N4O2/c28-19(11-17-14-31-26-10-2-1-5-22(17)26)16-33-20-12-18(13-30-15-20)21-6-3-8-24-23(21)7-4-9-25(24)27(29)32/h1-10,12-15,19,31H,11,16,28H2,(H2,29,32)/t19-/m0/s1	PDB MMDB B.MOAD GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.17E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair
Protein kinase B (Akt 1) (Homo sapiens (Human))	BDBM15056 (4-N-(4-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]p...) Show SMILES N[C@H](COc1cncc(c1)-c1ccc(Nc2ccnc(N)n2)cc1)Cc1c[nH]c2ccccc12 Show InChI InChI=1S/C26H25N7O/c27-20(11-19-14-31-24-4-2-1-3-23(19)24)16-34-22-12-18(13-29-15-22)17-5-7-21(8-6-17)32-25-9-10-30-26(28)33-25/h1-10,12-15,20,31H,11,16,27H2,(H3,28,30,32,33)/t20-/m0/s1	PDB MMDB B.MOAD GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.71E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair
Protein kinase B (Akt 1) (Homo sapiens (Human))	BDBM15032 (5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]-N-(pyrid...) Show SMILES N[C@H](COc1cncc(Nc2ccncc2)c1)Cc1c[nH]c2ccccc12 Show InChI InChI=1S/C21H21N5O/c22-16(9-15-11-25-21-4-2-1-3-20(15)21)14-27-19-10-18(12-24-13-19)26-17-5-7-23-8-6-17/h1-8,10-13,16,25H,9,14,22H2,(H,23,26)/t16-/m0/s1	PDB MMDB B.MOAD GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.86E+3	n/a	n/a	n/a	n/a	7.5	22
Abbott Laboratories					Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair
Protein kinase B (Akt 1) (Homo sapiens (Human))	BDBM15058 (N-(3-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyr...) Show SMILES N[C@H](COc1cncc(c1)-c1cccc(Nc2ncccn2)c1)Cc1c[nH]c2ccccc12 Show InChI InChI=1S/C26H24N6O/c27-21(11-20-15-31-25-8-2-1-7-24(20)25)17-33-23-13-19(14-28-16-23)18-5-3-6-22(12-18)32-26-29-9-4-10-30-26/h1-10,12-16,21,31H,11,17,27H2,(H,29,30,32)/t21-/m0/s1	PDB MMDB B.MOAD GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.67E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair
Protein kinase C (PKC) (Homo sapiens (Human))	BDBM15067 ((2S)-1-(1H-indol-3-yl)-3-(5-isoquinolin-6-ylpyridi...) Show SMILES N[C@H](COc1cncc(c1)-c1ccc2cnccc2c1)Cc1c[nH]c2ccccc12 Show InChI InChI=1S/C25H22N4O/c26-22(10-21-14-29-25-4-2-1-3-24(21)25)16-30-23-11-20(13-28-15-23)17-5-6-19-12-27-8-7-18(19)9-17/h1-9,11-15,22,29H,10,16,26H2/t22-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	6.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The kinase assay uses purified recombinant enzyme and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidi...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair
Protein kinase B (Akt 1) (Homo sapiens (Human))	BDBM15059 (N-(3-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyr...) Show SMILES N[C@H](COc1cncc(c1)-c1cccc(Nc2nccs2)c1)Cc1c[nH]c2ccccc12 Show InChI InChI=1S/C25H23N5OS/c26-20(10-19-14-29-24-7-2-1-6-23(19)24)16-31-22-12-18(13-27-15-22)17-4-3-5-21(11-17)30-25-28-8-9-32-25/h1-9,11-15,20,29H,10,16,26H2,(H,28,30)/t20-/m0/s1	PDB MMDB B.MOAD GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.23E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair
Protein kinase B (Akt 1) (Homo sapiens (Human))	BDBM15042 (4-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridi...) Show SMILES N[C@H](COc1cncc(c1)-c1ccc(N)cc1)Cc1c[nH]c2ccccc12 Show InChI InChI=1S/C22H22N4O/c23-18-7-5-15(6-8-18)16-10-20(13-25-11-16)27-14-19(24)9-17-12-26-22-4-2-1-3-21(17)22/h1-8,10-13,19,26H,9,14,23-24H2/t19-/m0/s1	PDB MMDB B.MOAD GoogleScholar	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	6.94E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair
Protein kinase B (Akt 1) (Homo sapiens (Human))	BDBM15035 (5-[(2S)-2-amino-3-phenylpropoxy]-N-(pyridin-3-yl)p...) Show SMILES N[C@H](COc1cncc(Nc2cccnc2)c1)Cc1ccccc1 Show InChI InChI=1S/C19H20N4O/c20-16(9-15-5-2-1-3-6-15)14-24-19-10-18(12-22-13-19)23-17-7-4-8-21-11-17/h1-8,10-13,16,23H,9,14,20H2/t16-/m0/s1	PDB MMDB B.MOAD GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.97E+3	n/a	n/a	n/a	n/a	7.5	22
Abbott Laboratories					Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair
Protein kinase B (Akt 1) (Homo sapiens (Human))	BDBM15063 (3-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]-6-(pyrid...) Show SMILES N[C@H](COc1cnc2ccc(cc2c1)-c1cccnc1)Cc1c[nH]c2ccccc12 Show InChI InChI=1S/C25H22N4O/c26-21(11-20-14-28-25-6-2-1-5-23(20)25)16-30-22-12-19-10-17(7-8-24(19)29-15-22)18-4-3-9-27-13-18/h1-10,12-15,21,28H,11,16,26H2/t21-/m0/s1	PDB MMDB B.MOAD GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.09E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair
Protein kinase B (Akt 1) (Homo sapiens (Human))	BDBM15044 (4-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridi...) Show SMILES N[C@H](COc1cncc(c1)-c1ccc(cc1)C(N)=O)Cc1c[nH]c2ccccc12 Show InChI InChI=1S/C23H22N4O2/c24-19(9-18-12-27-22-4-2-1-3-21(18)22)14-29-20-10-17(11-26-13-20)15-5-7-16(8-6-15)23(25)28/h1-8,10-13,19,27H,9,14,24H2,(H2,25,28)/t19-/m0/s1	PDB MMDB B.MOAD GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.31E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair
Protein kinase B (Akt 1) (Homo sapiens (Human))	BDBM15031 (2-{5-[(2S)-2-amino-3-phenylpropoxy]pyridin-3-yl}-4...) Show SMILES N[C@H](COc1cncc(c1)-c1nc(cs1)-c1cccnc1)Cc1ccccc1 Show InChI InChI=1S/C22H20N4OS/c23-19(9-16-5-2-1-3-6-16)14-27-20-10-18(12-25-13-20)22-26-21(15-28-22)17-7-4-8-24-11-17/h1-8,10-13,15,19H,9,14,23H2/t19-/m0/s1	PDB MMDB B.MOAD GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.35E+3	n/a	n/a	n/a	n/a	7.5	22
Abbott Laboratories					Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair
Protein kinase B (Akt 1) (Homo sapiens (Human))	BDBM15030 (2-{5-[(2S)-2-amino-3-phenylpropoxy]pyridin-3-yl}-4...) Show SMILES N[C@H](COc1cncc(c1)-c1nc(cs1)-c1ccncc1)Cc1ccccc1 Show InChI InChI=1S/C22H20N4OS/c23-19(10-16-4-2-1-3-5-16)14-27-20-11-18(12-25-13-20)22-26-21(15-28-22)17-6-8-24-9-7-17/h1-9,11-13,15,19H,10,14,23H2/t19-/m0/s1	PDB MMDB B.MOAD GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.87E+3	n/a	n/a	n/a	n/a	7.5	22
Abbott Laboratories					Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair
Protein kinase B (Akt 1) (Homo sapiens (Human))	BDBM15051 (N-(3-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyr...) Show SMILES CC(=O)Nc1cccc(c1)-c1cncc(OC[C@@H](N)Cc2c[nH]c3ccccc23)c1 Show InChI InChI=1S/C24H24N4O2/c1-16(29)28-21-6-4-5-17(10-21)18-11-22(14-26-12-18)30-15-20(25)9-19-13-27-24-8-3-2-7-23(19)24/h2-8,10-14,20,27H,9,15,25H2,1H3,(H,28,29)/t20-/m0/s1	PDB MMDB B.MOAD GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair
Protein kinase B (Akt 1) (Homo sapiens (Human))	BDBM15057 (N-(4-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyr...) Show SMILES N[C@H](COc1cncc(c1)-c1ccc(Nc2ncccn2)cc1)Cc1c[nH]c2ccccc12 Show InChI InChI=1S/C26H24N6O/c27-21(12-20-15-31-25-5-2-1-4-24(20)25)17-33-23-13-19(14-28-16-23)18-6-8-22(9-7-18)32-26-29-10-3-11-30-26/h1-11,13-16,21,31H,12,17,27H2,(H,29,30,32)/t21-/m0/s1	PDB MMDB B.MOAD GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.43E+4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair
Protein kinase B (Akt 1) (Homo sapiens (Human))	BDBM15034 (5-[(2S)-2-amino-3-phenylpropoxy]-N-(pyridin-4-yl)p...) Show SMILES N[C@H](COc1cncc(Nc2ccncc2)c1)Cc1ccccc1 Show InChI InChI=1S/C19H20N4O/c20-16(10-15-4-2-1-3-5-15)14-24-19-11-18(12-22-13-19)23-17-6-8-21-9-7-17/h1-9,11-13,16H,10,14,20H2,(H,21,23)/t16-/m0/s1	PDB MMDB B.MOAD GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.88E+4	n/a	n/a	n/a	n/a	7.5	22
Abbott Laboratories					Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair
Protein kinase B (Akt 1) (Homo sapiens (Human))	BDBM15024 (3-[(2S)-2-amino-3-({5-[2-(pyridin-3-yl)ethynyl]pyr...) Show SMILES N[C@H](COc1cncc(c1)C#Cc1cccnc1)Cc1c[nH]c2ccccc12 Show InChI InChI=1S/C23H20N4O/c24-20(11-19-14-27-23-6-2-1-5-22(19)23)16-28-21-10-18(13-26-15-21)8-7-17-4-3-9-25-12-17/h1-6,9-10,12-15,20,27H,11,16,24H2/t20-/m0/s1	PDB MMDB B.MOAD GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.52E+4	n/a	n/a	n/a	n/a	7.5	22
Abbott Laboratories					Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat...				Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX
					More data for this Ligand-Target Pair

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