Compile Data Set for Download or QSAR
maximum 50k data
Found 39 Enz. Inhib. hit(s) with all data for entry = 2788
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Astex

LigandPNGBDBM24644(4-N-(2,6-difluorobenzene)-3-N-(4-fluorophenyl)-1H-...)
Affinity DataIC50:  3nMpH: 7.2 T: 2°CAssay Description:CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
LigandPNGBDBM24644(4-N-(2,6-difluorobenzene)-3-N-(4-fluorophenyl)-1H-...)
Affinity DataIC50:  10nMAssay Description:CDK1/cyclin B activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Astex

LigandPNGBDBM24646(3-N-cyclohexyl-4-N-(2,6-difluorobenzene)-1H-pyrazo...)
Affinity DataIC50:  12nMpH: 7.2 T: 2°CAssay Description:CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Astex

LigandPNGBDBM24654(4-N-(2,6-dichlorobenzene)-3-N-(piperidin-4-yl)-1H-...)
Affinity DataIC50:  18nMAssay Description:CDK5/p35 activity was determined in DELFIA format using a biotinylated Histone H1 peptide. The phosphorylated peptide was quantified using rabbit pho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Astex

LigandPNGBDBM24647(4-N-(2,6-difluorobenzene)-3-N-(4-hydroxycyclohexyl...)
Affinity DataIC50:  19nMpH: 7.2 T: 2°CAssay Description:CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Astex

LigandPNGBDBM24645(3-N-(cyclopropylmethyl)-4-N-(2,6-difluorobenzene)-...)
Affinity DataIC50:  25nMpH: 7.2 T: 2°CAssay Description:CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Astex

LigandPNGBDBM24633(5-[(4-aminocyclohexyl)amino]-7-(propan-2-ylamino)p...)
Affinity DataIC50:  30nMpH: 7.2 T: 2°CAssay Description:CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Astex

LigandPNGBDBM24652(4-N-(2-fluoro-6-methoxybenzene)-3-N-(piperidin-4-y...)
Affinity DataIC50:  35nMpH: 7.2 T: 2°CAssay Description:CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Astex

LigandPNGBDBM24648(3-N-(4-aminocyclohexyl)-4-N-(2,6-difluorobenzene)-...)
Affinity DataIC50:  38nMpH: 7.2 T: 2°CAssay Description:CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM24650(4-N-(2,6-difluorobenzene)-3-N-[(3S)-piperidin-3-yl...)
Affinity DataIC50:  38nMAssay Description:CDK1/cyclin B activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Astex

LigandPNGBDBM24650(4-N-(2,6-difluorobenzene)-3-N-[(3S)-piperidin-3-yl...)
Affinity DataIC50:  44nMpH: 7.2 T: 2°CAssay Description:CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
LigandPNGBDBM24647(4-N-(2,6-difluorobenzene)-3-N-(4-hydroxycyclohexyl...)
Affinity DataIC50:  45nMAssay Description:CDK1/cyclin B activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Astex

LigandPNGBDBM24654(4-N-(2,6-dichlorobenzene)-3-N-(piperidin-4-yl)-1H-...)
Affinity DataIC50:  47nMpH: 7.2 T: 2°CAssay Description:CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
LigandPNGBDBM24646(3-N-cyclohexyl-4-N-(2,6-difluorobenzene)-1H-pyrazo...)
Affinity DataIC50:  55nMAssay Description:CDK1/cyclin B activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Astex

LigandPNGBDBM24642(4-N-cyclohexane-3-N-(4-fluorophenyl)-1H-pyrazole-3...)
Affinity DataIC50:  90nMpH: 7.2 T: 2°CAssay Description:CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Astex

LigandPNGBDBM24653(4-N-(2-chloro-6-fluorobenzene)-3-N-(piperidin-4-yl...)
Affinity DataIC50:  110nMpH: 7.2 T: 2°CAssay Description:CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Astex

LigandPNGBDBM24643(4-N-benzene-3-N-(4-fluorophenyl)-1H-pyrazole-3,4-d...)
Affinity DataIC50:  140nMpH: 7.2 T: 2°CAssay Description:CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Astex

LigandPNGBDBM24649(4-N-(2,6-difluorobenzene)-3-N-(piperidin-4-yl)-1H-...)
Affinity DataIC50:  140nMpH: 7.2 T: 2°CAssay Description:CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
LigandPNGBDBM24654(4-N-(2,6-dichlorobenzene)-3-N-(piperidin-4-yl)-1H-...)
Affinity DataIC50:  190nMAssay Description:CDK1/cyclin B activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Astex

LigandPNGBDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)
Affinity DataIC50:  370nMpH: 7.2 T: 2°CAssay Description:CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
LigandPNGBDBM24648(3-N-(4-aminocyclohexyl)-4-N-(2,6-difluorobenzene)-...)
Affinity DataIC50:  440nMAssay Description:CDK1/cyclin B activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Astex

LigandPNGBDBM24635(N-(4-sulfamoylphenyl)-1H-indazole-3-carboxamide | ...)
Affinity DataIC50:  660nMpH: 7.2 T: 2°CAssay Description:CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Astex

LigandPNGBDBM24640(N-(4-fluorophenyl)-4-(2-hydroxyacetamido)-1H-pyraz...)
Affinity DataIC50:  730nMpH: 7.2 T: 2°CAssay Description:CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Astex

LigandPNGBDBM24651(3-N-(piperidin-4-yl)-4-N-(2,4,6-trifluorobenzene)-...)
Affinity DataIC50:  750nMpH: 7.2 T: 2°CAssay Description:CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Astex

LigandPNGBDBM24639(4-acetamido-N-(4-fluorophenyl)-1H-pyrazole-3-carbo...)
Affinity DataIC50:  850nMpH: 7.2 T: 2°CAssay Description:CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
LigandPNGBDBM24649(4-N-(2,6-difluorobenzene)-3-N-(piperidin-4-yl)-1H-...)
Affinity DataIC50:  980nMAssay Description:CDK1/cyclin B activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Astex

LigandPNGBDBM24632(5-chloro-7-(propan-2-ylamino)pyrazolo[1,5-a]pyrimi...)
Affinity DataIC50:  1.50E+3nMpH: 7.2 T: 2°CAssay Description:CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Astex

LigandPNGBDBM24641(N-(4-fluorophenyl)-4-(2-phenylacetamido)-1H-pyrazo...)
Affinity DataIC50:  1.60E+3nMpH: 7.2 T: 2°CAssay Description:CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Astex

LigandPNGBDBM24631(4-[(6-chloropyrazin-2-yl)amino]benzene-1-sulfonami...)
Affinity DataIC50:  1.90E+3nMpH: 7.2 T: 2°CAssay Description:CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Astex

LigandPNGBDBM24634(N-phenyl-1H-indazole-3-carboxamide | indazole amid...)
Affinity DataIC50:  3.00E+3nMpH: 7.2 T: 2°CAssay Description:CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Astex

LigandPNGBDBM24630(6-chloro-N-phenylpyrazin-2-amine | 6-chloro-N-phen...)
Affinity DataIC50:  7.00E+3nMpH: 7.2 T: 2°CAssay Description:CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Astex

LigandPNGBDBM24654(4-N-(2,6-dichlorobenzene)-3-N-(piperidin-4-yl)-1H-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Aurora A kinase activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into Kemptide....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Astex

LigandPNGBDBM24637(2-(1H-pyrazol-3-yl)-1H-1,3-benzodiazole | JMC52379...)
Affinity DataIC50:  2.50E+4nMpH: 7.2 T: 2°CAssay Description:CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Astex

LigandPNGBDBM24638(4-amino-N-(4-fluorophenyl)-1H-pyrazole-3-carboxami...)
Affinity DataIC50:  8.50E+4nMpH: 7.2 T: 2°CAssay Description:CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Astex

LigandPNGBDBM24636(N-phenyl-1H-pyrazole-3-carboxamide | pyrazole amid...)
Affinity DataIC50:  9.70E+4nMpH: 7.2 T: 2°CAssay Description:CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Astex

LigandPNGBDBM24628(5-hydroxynaphthalene-1-sulfonamide | 5-hydroxynaph...)
Affinity DataIC50:  1.20E+5nMpH: 7.2 T: 2°CAssay Description:CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Astex

LigandPNGBDBM24627(1H-indazole | Indazole, 5 | Indazole, 6)
Affinity DataIC50:  1.85E+5nMpH: 7.2 T: 2°CAssay Description:CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Astex

LigandPNGBDBM24629(pyrazolo[1,5-a]pyrimidine-3-carbonitrile | pyrazol...)
Affinity DatapH: 7.2 T: 2°CAssay Description:CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Astex

LigandPNGBDBM24626(6-chloropyrazin-2-amine | 6-chloropyrazin-2-amine,...)
Affinity DatapH: 7.2 T: 2°CAssay Description:CDK2/cyclin A activity was determined using a radiometric assay to measure the incorporation of gamma-phosphate from [gamma-33P]-ATP into histone H1....More data for this Ligand-Target Pair