Compile Data Set for Download or QSAR
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Found 7 Enz. Inhib. hit(s) with all data for entry = 50047112
TargetEgl nine homolog 1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM118339(US8653111, 72)
Affinity DataIC50:  280nMAssay Description:Inhibition of PHD2 (unknown origin) using biotinylated HIF-1alpha (558 to 574 residues) as substrate after 1 hr by homogeneous time-resolved fluoresc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50193145(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)
Affinity DataIC50:  300nMAssay Description:Inhibition of recombinant PHD2 (unknown origin) catalytic domain (181 to 426 residues) expressed in Escherichia coli BL21 (DE3) cells using boitinyla...More data for this Ligand-Target Pair
TargetEgl nine homolog 1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50193145(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)
Affinity DataIC50:  424nMAssay Description:Displacement of FITC-HIF-1alpha (556 to 574 residues) from PHD2 (181 to 426 residues) (unknown origin) after 60 mins by fluorescence polarization ass...More data for this Ligand-Target Pair
TargetEgl nine homolog 1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50431015(CHEMBL2338329 | US10889546, FG-4592 | US9115085, C...)
Affinity DataIC50:  591nMAssay Description:Displacement of FITC-HIF-1alpha (556 to 574 residues) from PHD2 (181 to 426 residues) (unknown origin) after 60 mins by fluorescence polarization ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM107698(US11426393, Compound Table XV.4 | US8598210, Table...)
Affinity DataIC50:  650nMAssay Description:Inhibition of recombinant human PHD2 (179 to 426 residues) using HIF-1alpha (556 to 574 residues) as substrate after 20 mins by MALDI-TOF MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM118339(US8653111, 72)
Affinity DataIC50:  876nMAssay Description:Displacement of FITC-HIF-1alpha (556 to 574 residues) from PHD2 (181 to 426 residues) (unknown origin) after 60 mins by fluorescence polarization ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM107698(US11426393, Compound Table XV.4 | US8598210, Table...)
Affinity DataIC50:  890nMAssay Description:Displacement of FITC-HIF-1alpha (556 to 574 residues) from PHD2 (181 to 426 residues) (unknown origin) after 60 mins by fluorescence polarization ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed