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Found 10 Enz. Inhib. hit(s) with all data for entry = 50030130
TargetDNA topoisomerase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50008936((S)-10-Amino-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-o...)
Affinity DataIC50:  1.80E+3nMAssay Description:Concentration required to inhibit 50% relaxation of 250 ng of SV40 DNA obtained with 0.5 I.U topoisomerase I at 37 degrees C for 30 minMore data for this Ligand-Target Pair
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TargetDNA topoisomerase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291417((E)-3-((S)-4-Ethyl-4-hydroxy-3,13-dioxo-3,4,12,13-...)
Affinity DataIC50:  3.20E+3nMAssay Description:Concentration required to inhibit 50% relaxation of 250 ng of SV40 DNA obtained with 0.5 I.U topoisomerase I at 37 degrees C for 30 minMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDNA topoisomerase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291415((S)-4-Ethyl-4-hydroxy-10-vinyl-1,12-dihydro-4H-2-o...)
Affinity DataIC50:  4.20E+3nMAssay Description:Concentration required to inhibit 50% relaxation of 250 ng of SV40 DNA obtained with 0.5 I.U topoisomerase I at 37 degrees C for 30 minMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDNA topoisomerase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291418((E)-3-((S)-4-Ethyl-4-hydroxy-3,13-dioxo-3,4,12,13-...)
Affinity DataIC50:  6.70E+3nMAssay Description:Concentration required to inhibit 50% relaxation of 250 ng of SV40 DNA obtained with 0.5 I.U topoisomerase I at 37 degrees C for 30 minMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDNA topoisomerase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291416(2-Acetylamino-3-((S)-4-ethyl-4-hydroxy-3,13-dioxo-...)
Affinity DataIC50:  1.13E+4nMAssay Description:Concentration required to inhibit 50% relaxation of 250 ng of SV40 DNA obtained with 0.5 I.U topoisomerase I at 37 degrees C for 30 minMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDNA topoisomerase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291412((Z)-2-Acetylamino-3-((S)-4-ethyl-4-hydroxy-3,13-di...)
Affinity DataIC50:  3.19E+4nMAssay Description:Concentration required to inhibit 50% relaxation of 250 ng of SV40 DNA obtained with 0.5 I.U topoisomerase I at 37 degrees C for 30 minMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDNA topoisomerase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291410(3-((S)-4-Ethyl-4-hydroxy-3,13-dioxo-3,4,12,13-tetr...)
Affinity DataIC50:  4.18E+4nMAssay Description:Concentration required to inhibit 50% relaxation of 250 ng of SV40 DNA obtained with 0.5 I.U topoisomerase I at 37 degrees C for 30 minMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDNA topoisomerase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291414((S)-4-Ethyl-4-hydroxy-10-phenethyl-1,12-dihydro-4H...)
Affinity DataIC50: >1.00E+5nMAssay Description:Concentration required to inhibit 50% relaxation of 250 ng of SV40 DNA obtained with 0.5 I.U topoisomerase I at 37 degrees C for 30 minMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDNA topoisomerase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291411((S)-4-Ethyl-4-hydroxy-10-((E)-styryl)-1,12-dihydro...)
Affinity DataIC50: >1.00E+5nMAssay Description:Concentration required to inhibit 50% relaxation of 250 ng of SV40 DNA obtained with 0.5 I.U topoisomerase I at 37 degrees C for 30 minMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDNA topoisomerase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291413((E)-3-((S)-4-Ethyl-4-hydroxy-3,13-dioxo-3,4,12,13-...)
Affinity DataIC50: >1.00E+5nMAssay Description:Concentration required to inhibit 50% relaxation of 250 ng of SV40 DNA obtained with 0.5 I.U topoisomerase I at 37 degrees C for 30 minMore data for this Ligand-Target Pair
In DepthDetails Article