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Found 12 Enz. Inhib. hit(s) with all data for entry = 50032255
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50326284(1-(beta-D-Glucopyranosyl)-4-methyl-3-(5-(4-fluorop...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside uptake after 120 mins by liquid scint...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50326280(1-(beta-D-Glucopyranosyl)-4-chloro-3-(5-chloro-2-t...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside uptake after 120 mins by liquid scint...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM20877(3-(1-benzofuran-5-yl)-1-(2-hydroxy-4-methyl-6-{[(2...)
Affinity DataIC50:  5.20nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside uptake after 120 mins by liquid scint...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50326283(1-(beta-D-Glucopyranosyl)-4-methyl-3-(5-(4-fluorop...)
Affinity DataIC50:  8.10nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside uptake after 120 mins by liquid scint...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50326279(1-(beta-D-Glucopyranosyl)-3-(5-ethyl-2-thienylmeth...)
Affinity DataIC50:  17nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside uptake after 120 mins by liquid scint...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50326282(1-(beta-D-Glucopyranosyl)-4-chloro-3-(2-ethyl-5-py...)
Affinity DataIC50:  28nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside uptake after 120 mins by liquid scint...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50326281(1-(beta-D-Glucopyranosyl)-4-chloro-3-(1-phenyl-1H-...)
Affinity DataIC50:  32nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside uptake after 120 mins by liquid scint...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM20877(3-(1-benzofuran-5-yl)-1-(2-hydroxy-4-methyl-6-{[(2...)
Affinity DataIC50:  240nMAssay Description:Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside uptake after 120 mins by liquid scint...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 1(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50326284(1-(beta-D-Glucopyranosyl)-4-methyl-3-(5-(4-fluorop...)
Affinity DataIC50:  910nMAssay Description:Inhibition of human SGLT1 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside uptake after 120 mins by liquid scint...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50326278(1-(beta-D-Glucopyranosyl)-3-(5-ethyl-2-furylmethyl...)
Affinity DataIC50:  920nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of [14C]-alpha-methyl-D-glucopyranoside uptake after 120 mins by liquid scint...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier family 2, facilitated glucose transporter member 1(Rattus norvegicus)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM20877(3-(1-benzofuran-5-yl)-1-(2-hydroxy-4-methyl-6-{[(2...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of GLUT1-mediated [3H]2-deoxy-glucose uptake in rat L6 cells after 15 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSolute carrier family 2, facilitated glucose transporter member 1(Rattus norvegicus)
Mitsubishi Tanabe Pharma

Curated by ChEMBL
LigandPNGBDBM50326284(1-(beta-D-Glucopyranosyl)-4-methyl-3-(5-(4-fluorop...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of GLUT1-mediated [3H]2-deoxy-glucose uptake in rat L6 cells after 15 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed