Compile Data Set for Download or QSAR
maximum 50k data
Found 119 Enz. Inhib. hit(s) with all data for entry = 50049209
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50144508(4-Methyl-1-(5-phenyl-pentyl)-piperidine | CHEMBL30...)
Affinity DataKi:  0.0700nMAssay Description:Displacement of (+)-[3H]pentazocine from guinea pig brain membrane sigma1 receptor by scintillation spectrometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50236721(CHEMBL4073530)
Affinity DataKi:  0.0800nMAssay Description:The compound was tested for inhibition of [3H]-5-hydroxy tryptamine uptake in HEK cells by expressing cDNA for human tryptamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50236715(CHEMBL4067210)
Affinity DataKi:  0.130nMAssay Description:Binding affinity towards Opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50236730(CHEMBL4072342)
Affinity DataKi:  0.140nMAssay Description:Binding affinity against human progesterone receptor (hPR) in a competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50064708((R)-1-(4-bromo-2,5-dimethoxyphenyl)propan-2-amine ...)
Affinity DataKi:  0.200nMAssay Description:The compound was evaluated for binding affinity against ProthrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50041246(CHEMBL19544 | Methyl-phenethyl-(5-phenyl-pentyl)-a...)
Affinity DataKi:  0.25nMAssay Description:Displacement of (+)-[3H]pentazocine from guinea pig brain membrane sigma1 receptor by scintillation spectrometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50041275(CHEMBL20348 | Methyl-(5-phenyl-pentyl)-propyl-amin...)
Affinity DataKi:  0.290nMAssay Description:Displacement of (+)-[3H]pentazocine from guinea pig brain membrane sigma1 receptor by scintillation spectrometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50156192((1R,2R)-2-(4-Bromo-2,5-dimethoxy-phenyl)-2-methoxy...)
Affinity DataKi:  0.300nMAssay Description:Displacement of [125I](+/-)DOI from rat 5HT2A after 1 hr by beta scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50041251(1-(5-Phenyl-pentyl)-piperidine | CHEMBL20188)
Affinity DataKi:  0.380nMAssay Description:Displacement of (+)-[3H]pentazocine from guinea pig brain membrane sigma1 receptor by scintillation spectrometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50156193((1R,2R)-2-Amino-1-(4-bromo-2,5-dimethoxy-phenyl)-p...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [125I](+/-)DOI from rat 5HT2A after 1 hr by beta scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50041237(((R)-1-Methyl-2-phenyl-ethyl)-(5-phenyl-pentyl)-am...)
Affinity DataKi:  0.5nMAssay Description:Displacement of (+)-[3H]pentazocine from guinea pig brain membrane sigma1 receptor by scintillation spectrometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50005257((+)-2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethy...)
Affinity DataKi:  0.600nMAssay Description:Displacement of [125I]DOI from recombinant human 5HT2A expressed in Syrian hamster AV12 cell membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM28582(1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine | CHE...)
Affinity DataKi:  0.700nMAssay Description:Binding affinity towards Cholecystokinin type B receptor in mouse cortex membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM28582(1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine | CHE...)
Affinity DataKi:  0.700nMAssay Description:Antagonist activity against human progesterone receptor (hPR) in T47D human breast cancer cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50005257((+)-2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethy...)
Affinity DataKi:  0.800nMAssay Description:Antagonist activity against human progesterone receptor (hPR) in T47D human breast cancer cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50156185((1S,2R)-2-(4-Bromo-2,5-dimethoxy-phenyl)-2-methoxy...)
Affinity DataKi:  0.800nMAssay Description:Displacement of [125I](+/-)DOI from rat 5HT2A after 1 hr by beta scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50041266(((S)-1-Methyl-2-phenyl-ethyl)-(5-phenyl-pentyl)-am...)
Affinity DataKi:  0.900nMAssay Description:Displacement of (+)-[3H]pentazocine from guinea pig brain membrane sigma1 receptor by scintillation spectrometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50156189((1R,2S)-2-Amino-1-(4-bromo-2,5-dimethoxy-phenyl)-p...)
Affinity DataKi:  1.10nMAssay Description:Antagonist activity against human progesterone receptor (hPR) in T47D human breast cancer cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM21393(7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-o...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]-8-OH-DPAT from 5-HT1A receptor in rat hippocampal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM21395(3-(2-(4-(4-Fluorobenzoyl)piperidinol)ethyl)-2,4(1H...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity against human progesterone receptor (hPR) in a competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50016737((8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-dip...)
Affinity DataKi:  1.30nMAssay Description:Time dependent inhibition against neuronal Nitric Oxide Synthase(nNOS)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50395860(CHEMBL2165520)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50016743(7-(3-Phenyl-propylamino)-5,6,7,8-tetrahydro-naphth...)
Affinity DataKi:  1.90nMAssay Description:Displacement of [3H]-8-OH-DPAT from 5-HT1A receptor in rat hippocampal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50016740((8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-met...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]-8-OH-DPAT from 5-HT1A receptor in rat hippocampal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50156188(2-(4-Bromo-2,5-dimethoxy-phenyl)-2-methoxy-ethylam...)
Affinity DataKi:  2nMAssay Description:Displacement of [125I](+/-)DOI from rat 5HT2A after 1 hr by beta scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM34141(CHEMBL76237 | MS-245)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50156191(2-Amino-1-(4-bromo-2,5-dimethoxy-phenyl)-ethanol |...)
Affinity DataKi:  2.10nMAssay Description:Antagonist activity against human progesterone receptor (hPR) in T47D human breast cancer cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50016745((8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-met...)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]-8-OH-DPAT from 5-HT1A receptor in rat hippocampal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50016736((8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-pro...)
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]-8-OH-DPAT from 5-HT1A receptor in rat hippocampal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM21395(3-(2-(4-(4-Fluorobenzoyl)piperidinol)ethyl)-2,4(1H...)
Affinity DataKi:  2.40nMAssay Description:Displacement of [3H]DOI-HCL from 5HT2A in Sprague-Dawley rat frontal cortex membranes measured after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50016738((8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-(3-...)
Affinity DataKi:  2.5nMAssay Description:Displacement of [3H]-8-OH-DPAT from 5-HT1A receptor in rat hippocampal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50236723(CHEMBL4064950)
Affinity DataKi:  2.5nMAssay Description:Binding affinity towards Opioid receptor mu 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50016777(((R)-8-Hydroxy-1,2,3,4-tetrahydro-naphthalen-2-yl)...)
Affinity DataKi:  4.80nMAssay Description:Displacement of [3H]-8-OH-DPAT from 5-HT1A receptor in Sprague-Dawley rat cortex membranes after 15 mins by liquid scintillation spectrometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50016744((8-Methoxy-1,2,3,4-tetrahydro-naphthalen-2-yl)-(4-...)
Affinity DataKi:  5.60nMAssay Description:The compound was evaluated for binding affinity against ProthrombinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50156195((1S,2S)-2-(4-Bromo-2,5-dimethoxy-phenyl)-2-methoxy...)
Affinity DataKi:  6nMAssay Description:Antagonist activity against human progesterone receptor (hPR) in T47D human breast cancer cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50091067(2-[2-Methoxy-4-(3-phenyl-propyl)-phenyl]-1-methyl-...)
Affinity DataKi:  8nMAssay Description:Binding affinity against human progesterone receptor (hPR) in a competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50156196((1S,2R)-2-Amino-1-(4-bromo-2,5-dimethoxy-phenyl)-p...)
Affinity DataKi:  9.20nMAssay Description:Human progesterone receptor (hPR) agonist activity in T47D human breast cancer cell lineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50016771(7-Diethylamino-5,6,7,8-tetrahydro-naphthalen-1-ol ...)
Affinity DataKi:  9.70nMAssay Description:Displacement of [3H]-8-OH-DPAT from 5-HT1A receptor in Sprague-Dawley rat cortex membranes after 15 mins by liquid scintillation spectrometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50156187((1S,2S)-2-Amino-1-(4-bromo-2,5-dimethoxy-phenyl)-p...)
Affinity DataKi:  10nMAssay Description:Displacement of [125I](+/-)DOI from rat 5HT2A after 1 hr by beta scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]DOI-HCL from 5HT2A in Sprague-Dawley rat frontal cortex membranes measured after 20 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50104815(2-[2-Methoxy-5-(3-phenyl-propyl)-phenyl]-1-methyl-...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]ketanserin from rat 5HT2A expressed in mouse NIH/3T3 cell membranes after 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50156184((1R,2S)-2-(4-Bromo-2,5-dimethoxy-phenyl)-2-methoxy...)
Affinity DataKi:  17nMAssay Description:Displacement of [125I](+/-)DOI from rat 5HT2A after 1 hr by beta scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50091076(2-[3-Methoxy-4-(3-phenyl-propyl)-phenyl]-1-methyl-...)
Affinity DataKi:  17nMAssay Description:Displacement of [3H]ketanserin from rat 5HT2A expressed in mouse NIH/3T3 cell membranes after 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM28582(1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine | CHE...)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]ketanserin from 5HT2A in Sprague-Dawley rat cortex membranes measured after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50104818(2-[2-Methoxy-5-(3-phenyl-propyl)-phenyl]-ethylamin...)
Affinity DataKi:  20nMAssay Description:Displacement of [3H]ketanserin from rat 5HT2A expressed in mouse NIH/3T3 cell membranes after 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50193463(CHEMBL212063 | N-(3-(2-aminoethyl)phenyl)benzenesu...)
Affinity DataKi:  21nMAssay Description:Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50014990(1-(2,5-dimethoxy-4-(3-phenylpropyl)phenyl)propan-2...)
Affinity DataKi:  30nMAssay Description:Displacement of [3H]ketanserin from rat 5HT2A expressed in mouse NIH/3T3 cell membranes after 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50193473(CHEMBL434365 | N-(4-(2-aminoethyl)phenyl)benzenesu...)
Affinity DataKi:  38nMAssay Description:Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50005257((+)-2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethy...)
Affinity DataKi:  41nMAssay Description:Displacement of [3H]ketanserin from 5HT2A in Sprague-Dawley rat cortex membranes measured after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Virginia Commonwealth University

Curated by ChEMBL
LigandPNGBDBM50005257((+)-2-(4-Bromo-2,5-dimethoxy-phenyl)-1-methyl-ethy...)
Affinity DataKi:  41nMAssay Description:Displacement of [3H]ketanserin from 5HT2A in Sprague-Dawley rat cortex membranes measured after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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