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Compile Data Set for Download or QSAR

Found 120 hits Enz. Inhib. hit(s) with all data for entry = 1683   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM335695
PNG
(US9737544, Compound 13)
Show SMILES COc1cc(OC)cc(c1)C(CCO)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H24N4O3/c1-27-14-17(13-25-27)16-10-23-22(24-12-16)5-4-21(26-23)20(6-7-28)15-8-18(29-2)11-19(9-15)30-3/h4-5,8-14,20,28H,6-7H2,1-3H3
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n/an/a 15.8n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM335677
PNG
(US9737544, Compound 6)
Show SMILES CNC(=O)\C=C(/c1cc(OC)cc(OC)c1)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H22N6O3/c1-24-22(30)10-18(14-7-16(31-3)9-17(8-14)32-4)19-5-6-20-23(27-19)28-21(12-25-20)15-11-26-29(2)13-15/h5-13H,1-4H3,(H,24,30)/b18-10+
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n/an/a 31.6n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Tri...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM335695
PNG
(US9737544, Compound 13)
Show SMILES COc1cc(OC)cc(c1)C(CCO)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H24N4O3/c1-27-14-17(13-25-27)16-10-23-22(24-12-16)5-4-21(26-23)20(6-7-28)15-8-18(29-2)11-19(9-15)30-3/h4-5,8-14,20,28H,6-7H2,1-3H3
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n/an/a 50.1n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Tri...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM335681
PNG
(US9737544, Compound 10)
Show SMILES COc1cc(OC)cc(c1)C(O)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C21H20N4O3/c1-25-12-15(11-23-25)14-8-20-18(22-10-14)4-5-19(24-20)21(26)13-6-16(27-2)9-17(7-13)28-3/h4-12,21,26H,1-3H3
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n/an/a 63.1n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM335682
PNG
(US9737544, Compound 14)
Show SMILES COc1cc(OC)cc(c1)C(CCO)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C22H23N5O3/c1-27-13-15(11-24-27)21-12-23-20-5-4-19(25-22(20)26-21)18(6-7-28)14-8-16(29-2)10-17(9-14)30-3/h4-5,8-13,18,28H,6-7H2,1-3H3
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n/an/a 63.1n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM335680
PNG
(US9737544, Compound 9)
Show SMILES CCOC(=O)CC(c1cc(OC)cc(OC)c1)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C25H26N4O4/c1-5-33-25(30)12-21(16-8-19(31-3)11-20(9-16)32-4)22-6-7-23-24(28-22)10-17(13-26-23)18-14-27-29(2)15-18/h6-11,13-15,21H,5,12H2,1-4H3
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n/an/a 79.4n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Tri...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM335695
PNG
(US9737544, Compound 13)
Show SMILES COc1cc(OC)cc(c1)C(CCO)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H24N4O3/c1-27-14-17(13-25-27)16-10-23-22(24-12-16)5-4-21(26-23)20(6-7-28)15-8-18(29-2)11-19(9-15)30-3/h4-5,8-14,20,28H,6-7H2,1-3H3
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n/an/a 79.4n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM335686
PNG
(US9737544, Compound 18)
Show SMILES Cn1cc(cn1)-c1cnc2ccc(nc2c1)C(=O)c1cccc(O)c1
Show InChI InChI=1S/C19H14N4O2/c1-23-11-14(10-21-23)13-8-18-16(20-9-13)5-6-17(22-18)19(25)12-3-2-4-15(24)7-12/h2-11,24H,1H3
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n/an/a 100n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, KDR (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trito...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM335680
PNG
(US9737544, Compound 9)
Show SMILES CCOC(=O)CC(c1cc(OC)cc(OC)c1)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C25H26N4O4/c1-5-33-25(30)12-21(16-8-19(31-3)11-20(9-16)32-4)22-6-7-23-24(28-22)10-17(13-26-23)18-14-27-29(2)15-18/h6-11,13-15,21H,5,12H2,1-4H3
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n/an/a 100n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM335677
PNG
(US9737544, Compound 6)
Show SMILES CNC(=O)\C=C(/c1cc(OC)cc(OC)c1)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H22N6O3/c1-24-22(30)10-18(14-7-16(31-3)9-17(8-14)32-4)19-5-6-20-23(27-19)28-21(12-25-20)15-11-26-29(2)13-15/h5-13H,1-4H3,(H,24,30)/b18-10+
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n/an/a 100n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM335681
PNG
(US9737544, Compound 10)
Show SMILES COc1cc(OC)cc(c1)C(O)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C21H20N4O3/c1-25-12-15(11-23-25)14-8-20-18(22-10-14)4-5-19(24-20)21(26)13-6-16(27-2)9-17(7-13)28-3/h4-12,21,26H,1-3H3
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n/an/a 126n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Tri...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM335677
PNG
(US9737544, Compound 6)
Show SMILES CNC(=O)\C=C(/c1cc(OC)cc(OC)c1)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H22N6O3/c1-24-22(30)10-18(14-7-16(31-3)9-17(8-14)32-4)19-5-6-20-23(27-19)28-21(12-25-20)15-11-26-29(2)13-15/h5-13H,1-4H3,(H,24,30)/b18-10+
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n/an/a 126n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM335679
PNG
(US9737544, Compound 8)
Show SMILES COc1cc(OC)cc(c1)C(=O)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C21H18N4O3/c1-25-12-15(11-23-25)14-8-20-18(22-10-14)4-5-19(24-20)21(26)13-6-16(27-2)9-17(7-13)28-3/h4-12H,1-3H3
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n/an/a 158n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM335682
PNG
(US9737544, Compound 14)
Show SMILES COc1cc(OC)cc(c1)C(CCO)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C22H23N5O3/c1-27-13-15(11-24-27)21-12-23-20-5-4-19(25-22(20)26-21)18(6-7-28)14-8-16(29-2)10-17(9-14)30-3/h4-5,8-13,18,28H,6-7H2,1-3H3
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n/an/a 158n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Tri...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM335680
PNG
(US9737544, Compound 9)
Show SMILES CCOC(=O)CC(c1cc(OC)cc(OC)c1)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C25H26N4O4/c1-5-33-25(30)12-21(16-8-19(31-3)11-20(9-16)32-4)22-6-7-23-24(28-22)10-17(13-26-23)18-14-27-29(2)15-18/h6-11,13-15,21H,5,12H2,1-4H3
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n/an/a 158n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM335679
PNG
(US9737544, Compound 8)
Show SMILES COc1cc(OC)cc(c1)C(=O)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C21H18N4O3/c1-25-12-15(11-23-25)14-8-20-18(22-10-14)4-5-19(24-20)21(26)13-6-16(27-2)9-17(7-13)28-3/h4-12H,1-3H3
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n/an/a 158n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Tri...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM335681
PNG
(US9737544, Compound 10)
Show SMILES COc1cc(OC)cc(c1)C(O)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C21H20N4O3/c1-25-12-15(11-23-25)14-8-20-18(22-10-14)4-5-19(24-20)21(26)13-6-16(27-2)9-17(7-13)28-3/h4-12,21,26H,1-3H3
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n/an/a 158n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM335696
PNG
(US9737544, Compound 11)
Show SMILES COc1cc(OC)cc(c1)C(OCCO)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H24N4O4/c1-27-14-17(13-25-27)16-10-22-20(24-12-16)4-5-21(26-22)23(31-7-6-28)15-8-18(29-2)11-19(9-15)30-3/h4-5,8-14,23,28H,6-7H2,1-3H3
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n/an/a 200n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM335686
PNG
(US9737544, Compound 18)
Show SMILES Cn1cc(cn1)-c1cnc2ccc(nc2c1)C(=O)c1cccc(O)c1
Show InChI InChI=1S/C19H14N4O2/c1-23-11-14(10-21-23)13-8-18-16(20-9-13)5-6-17(22-18)19(25)12-3-2-4-15(24)7-12/h2-11,24H,1H3
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n/an/a 200n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM335695
PNG
(US9737544, Compound 13)
Show SMILES COc1cc(OC)cc(c1)C(CCO)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H24N4O3/c1-27-14-17(13-25-27)16-10-23-22(24-12-16)5-4-21(26-23)20(6-7-28)15-8-18(29-2)11-19(9-15)30-3/h4-5,8-14,20,28H,6-7H2,1-3H3
PDB

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n/an/a 251n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR4 (h) (60 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM335696
PNG
(US9737544, Compound 11)
Show SMILES COc1cc(OC)cc(c1)C(OCCO)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H24N4O4/c1-27-14-17(13-25-27)16-10-22-20(24-12-16)4-5-21(26-22)23(31-7-6-28)15-8-18(29-2)11-19(9-15)30-3/h4-5,8-14,23,28H,6-7H2,1-3H3
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n/an/a 251n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Tri...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM335677
PNG
(US9737544, Compound 6)
Show SMILES CNC(=O)\C=C(/c1cc(OC)cc(OC)c1)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H22N6O3/c1-24-22(30)10-18(14-7-16(31-3)9-17(8-14)32-4)19-5-6-20-23(27-19)28-21(12-25-20)15-11-26-29(2)13-15/h5-13H,1-4H3,(H,24,30)/b18-10+
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, KDR (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trito...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM335673
PNG
(US9737544, Compound 2)
Show SMILES COc1cc(OC)cc(c1)C(O)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C20H19N5O3/c1-25-11-13(9-22-25)18-10-21-17-5-4-16(23-20(17)24-18)19(26)12-6-14(27-2)8-15(7-12)28-3/h4-11,19,26H,1-3H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM335686
PNG
(US9737544, Compound 18)
Show SMILES Cn1cc(cn1)-c1cnc2ccc(nc2c1)C(=O)c1cccc(O)c1
Show InChI InChI=1S/C19H14N4O2/c1-23-11-14(10-21-23)13-8-18-16(20-9-13)5-6-17(22-18)19(25)12-3-2-4-15(24)7-12/h2-11,24H,1H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Tri...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM335678
PNG
(US9737544, Compound 7)
Show SMILES CNC(=O)\C=C(\c1cc(OC)cc(OC)c1)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H22N6O3/c1-24-22(30)10-18(14-7-16(31-3)9-17(8-14)32-4)19-5-6-20-23(27-19)28-21(12-25-20)15-11-26-29(2)13-15/h5-13H,1-4H3,(H,24,30)/b18-10-
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Tri...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM335678
PNG
(US9737544, Compound 7)
Show SMILES CNC(=O)\C=C(\c1cc(OC)cc(OC)c1)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H22N6O3/c1-24-22(30)10-18(14-7-16(31-3)9-17(8-14)32-4)19-5-6-20-23(27-19)28-21(12-25-20)15-11-26-29(2)13-15/h5-13H,1-4H3,(H,24,30)/b18-10-
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM335682
PNG
(US9737544, Compound 14)
Show SMILES COc1cc(OC)cc(c1)C(CCO)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C22H23N5O3/c1-27-13-15(11-24-27)21-12-23-20-5-4-19(25-22(20)26-21)18(6-7-28)14-8-16(29-2)10-17(9-14)30-3/h4-5,8-13,18,28H,6-7H2,1-3H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM335684
PNG
(US9737544, Compound 16)
Show SMILES COc1cccc(c1)C(=O)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C20H16N4O2/c1-24-12-15(11-22-24)14-9-19-17(21-10-14)6-7-18(23-19)20(25)13-4-3-5-16(8-13)26-2/h3-12H,1-2H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM335680
PNG
(US9737544, Compound 9)
Show SMILES CCOC(=O)CC(c1cc(OC)cc(OC)c1)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C25H26N4O4/c1-5-33-25(30)12-21(16-8-19(31-3)11-20(9-16)32-4)22-6-7-23-24(28-22)10-17(13-26-23)18-14-27-29(2)15-18/h6-11,13-15,21H,5,12H2,1-4H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, KDR (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trito...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM335679
PNG
(US9737544, Compound 8)
Show SMILES COc1cc(OC)cc(c1)C(=O)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C21H18N4O3/c1-25-12-15(11-23-25)14-8-20-18(22-10-14)4-5-19(24-20)21(26)13-6-16(27-2)9-17(7-13)28-3/h4-12H,1-3H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM335678
PNG
(US9737544, Compound 7)
Show SMILES CNC(=O)\C=C(\c1cc(OC)cc(OC)c1)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H22N6O3/c1-24-22(30)10-18(14-7-16(31-3)9-17(8-14)32-4)19-5-6-20-23(27-19)28-21(12-25-20)15-11-26-29(2)13-15/h5-13H,1-4H3,(H,24,30)/b18-10-
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM335677
PNG
(US9737544, Compound 6)
Show SMILES CNC(=O)\C=C(/c1cc(OC)cc(OC)c1)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H22N6O3/c1-24-22(30)10-18(14-7-16(31-3)9-17(8-14)32-4)19-5-6-20-23(27-19)28-21(12-25-20)15-11-26-29(2)13-15/h5-13H,1-4H3,(H,24,30)/b18-10+
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR4 (h) (60 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM335675
PNG
(US9737544, Compound 4)
Show SMILES COC(=O)CC(c1cc(OC)cc(OC)c1)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H23N5O4/c1-28-13-15(11-25-28)21-12-24-20-6-5-19(26-23(20)27-21)18(10-22(29)32-4)14-7-16(30-2)9-17(8-14)31-3/h5-9,11-13,18H,10H2,1-4H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM335675
PNG
(US9737544, Compound 4)
Show SMILES COC(=O)CC(c1cc(OC)cc(OC)c1)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H23N5O4/c1-28-13-15(11-25-28)21-12-24-20-6-5-19(26-23(20)27-21)18(10-22(29)32-4)14-7-16(30-2)9-17(8-14)31-3/h5-9,11-13,18H,10H2,1-4H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Tri...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM335673
PNG
(US9737544, Compound 2)
Show SMILES COc1cc(OC)cc(c1)C(O)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C20H19N5O3/c1-25-11-13(9-22-25)18-10-21-17-5-4-16(23-20(17)24-18)19(26)12-6-14(27-2)8-15(7-12)28-3/h4-11,19,26H,1-3H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Tri...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM335697
PNG
(US9737544, Compound 15)
Show SMILES COc1cc(OC)cc(c1)C(Cc1nccn1S(=O)(=O)N(C)C)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C26H28N8O4S/c1-32(2)39(35,36)34-9-8-27-25(34)13-21(17-10-19(37-4)12-20(11-17)38-5)22-6-7-23-26(30-22)31-24(15-28-23)18-14-29-33(3)16-18/h6-12,14-16,21H,13H2,1-5H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Tri...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM335696
PNG
(US9737544, Compound 11)
Show SMILES COc1cc(OC)cc(c1)C(OCCO)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H24N4O4/c1-27-14-17(13-25-27)16-10-22-20(24-12-16)4-5-21(26-22)23(31-7-6-28)15-8-18(29-2)11-19(9-15)30-3/h4-5,8-14,23,28H,6-7H2,1-3H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM335697
PNG
(US9737544, Compound 15)
Show SMILES COc1cc(OC)cc(c1)C(Cc1nccn1S(=O)(=O)N(C)C)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C26H28N8O4S/c1-32(2)39(35,36)34-9-8-27-25(34)13-21(17-10-19(37-4)12-20(11-17)38-5)22-6-7-23-26(30-22)31-24(15-28-23)18-14-29-33(3)16-18/h6-12,14-16,21H,13H2,1-5H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM335697
PNG
(US9737544, Compound 15)
Show SMILES COc1cc(OC)cc(c1)C(Cc1nccn1S(=O)(=O)N(C)C)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C26H28N8O4S/c1-32(2)39(35,36)34-9-8-27-25(34)13-21(17-10-19(37-4)12-20(11-17)38-5)22-6-7-23-26(30-22)31-24(15-28-23)18-14-29-33(3)16-18/h6-12,14-16,21H,13H2,1-5H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM335695
PNG
(US9737544, Compound 13)
Show SMILES COc1cc(OC)cc(c1)C(CCO)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H24N4O3/c1-27-14-17(13-25-27)16-10-23-22(24-12-16)5-4-21(26-23)20(6-7-28)15-8-18(29-2)11-19(9-15)30-3/h4-5,8-14,20,28H,6-7H2,1-3H3
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ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, KDR (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trito...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM335681
PNG
(US9737544, Compound 10)
Show SMILES COc1cc(OC)cc(c1)C(O)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C21H20N4O3/c1-25-12-15(11-23-25)14-8-20-18(22-10-14)4-5-19(24-20)21(26)13-6-16(27-2)9-17(7-13)28-3/h4-12,21,26H,1-3H3
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n/an/a 631n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR4 (h) (60 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM335682
PNG
(US9737544, Compound 14)
Show SMILES COc1cc(OC)cc(c1)C(CCO)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C22H23N5O3/c1-27-13-15(11-24-27)21-12-23-20-5-4-19(25-22(20)26-21)18(6-7-28)14-8-16(29-2)10-17(9-14)30-3/h4-5,8-13,18,28H,6-7H2,1-3H3
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n/an/a 631n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR4 (h) (60 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM335673
PNG
(US9737544, Compound 2)
Show SMILES COc1cc(OC)cc(c1)C(O)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C20H19N5O3/c1-25-11-13(9-22-25)18-10-21-17-5-4-16(23-20(17)24-18)19(26)12-6-14(27-2)8-15(7-12)28-3/h4-11,19,26H,1-3H3
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n/an/a 794n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM335675
PNG
(US9737544, Compound 4)
Show SMILES COC(=O)CC(c1cc(OC)cc(OC)c1)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C23H23N5O4/c1-28-13-15(11-25-28)21-12-24-20-6-5-19(26-23(20)27-21)18(10-22(29)32-4)14-7-16(30-2)9-17(8-14)31-3/h5-9,11-13,18H,10H2,1-4H3
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n/an/a 794n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM335685
PNG
(US9737544, Compound 17)
Show SMILES COc1cccc(c1)C(O)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C20H18N4O2/c1-24-12-15(11-22-24)14-9-19-17(21-10-14)6-7-18(23-19)20(25)13-4-3-5-16(8-13)26-2/h3-12,20,25H,1-2H3
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n/an/a 794n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR3 (h) (40 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM335686
PNG
(US9737544, Compound 18)
Show SMILES Cn1cc(cn1)-c1cnc2ccc(nc2c1)C(=O)c1cccc(O)c1
Show InChI InChI=1S/C19H14N4O2/c1-23-11-14(10-21-23)13-8-18-16(20-9-13)5-6-17(22-18)19(25)12-3-2-4-15(24)7-12/h2-11,24H,1H3
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n/an/a 794n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM335685
PNG
(US9737544, Compound 17)
Show SMILES COc1cccc(c1)C(O)c1ccc2ncc(cc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C20H18N4O2/c1-24-12-15(11-22-24)14-9-19-17(21-10-14)6-7-18(23-19)20(25)13-4-3-5-16(8-13)26-2/h3-12,20,25H,1-2H3
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n/an/a 794n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Tri...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM335672
PNG
(US9737544, Compound 1)
Show SMILES COc1cc(OC)cc(c1)C(=O)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C20H17N5O3/c1-25-11-13(9-22-25)18-10-21-17-5-4-16(23-20(17)24-18)19(26)12-6-14(27-2)8-15(7-12)28-3/h4-11H,1-3H3
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n/an/a<1.00E+3n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR1 (h) (25 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trit...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM335672
PNG
(US9737544, Compound 1)
Show SMILES COc1cc(OC)cc(c1)C(=O)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C20H17N5O3/c1-25-11-13(9-22-25)18-10-21-17-5-4-16(23-20(17)24-18)19(26)12-6-14(27-2)8-15(7-12)28-3/h4-11H,1-3H3
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n/an/a<1.00E+3n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, FGFR2 (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Tri...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2 and tyrosine-protein kinase TIE-2 (KDR and TIE2)


(Homo sapiens (Human))
BDBM335672
PNG
(US9737544, Compound 1)
Show SMILES COc1cc(OC)cc(c1)C(=O)c1ccc2ncc(nc2n1)-c1cnn(C)c1
Show InChI InChI=1S/C20H17N5O3/c1-25-11-13(9-22-25)18-10-21-17-5-4-16(23-20(17)24-18)19(26)12-6-14(27-2)8-15(7-12)28-3/h4-11H,1-3H3
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n/an/a<1.00E+3n/an/an/an/an/an/a



ASTEX THERAPEUTICS LIMITED

US Patent


Assay Description
In a final reaction volume of 30 μL, KDR (h) (150 ng/ml) was incubated with 50 mM HEPES pH 7.5, 6 mM MnCl2, 1 mM DTT, 0.1 mM Na3VO4, 0.01% Trito...


US Patent US9737544 (2017)

More data for this
Ligand-Target Pair
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