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Compile Data Set for Download or QSAR

Found 266 hits Enz. Inhib. hit(s) with all data for entry = 1726   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM337264
PNG
(2-[2-(3,5-dimethoxyphenyl)ethyl]-6-[4-(4-methylpip...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccc(cc2)N2CCN(C)CC2)cc(OC)c1
Show InChI InChI=1S/C27H31N5O2/c1-31-10-12-32(13-11-31)22-8-5-20(6-9-22)25-17-26-27(30-25)28-18-21(29-26)7-4-19-14-23(33-2)16-24(15-19)34-3/h5-6,8-9,14-18H,4,7,10-13H2,1-3H3,(H,28,30)
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM337264
PNG
(2-[2-(3,5-dimethoxyphenyl)ethyl]-6-[4-(4-methylpip...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccc(cc2)N2CCN(C)CC2)cc(OC)c1
Show InChI InChI=1S/C27H31N5O2/c1-31-10-12-32(13-11-31)22-8-5-20(6-9-22)25-17-26-27(30-25)28-18-21(29-26)7-4-19-14-23(33-2)16-24(15-19)34-3/h5-6,8-9,14-18H,4,7,10-13H2,1-3H3,(H,28,30)
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM337264
PNG
(2-[2-(3,5-dimethoxyphenyl)ethyl]-6-[4-(4-methylpip...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccc(cc2)N2CCN(C)CC2)cc(OC)c1
Show InChI InChI=1S/C27H31N5O2/c1-31-10-12-32(13-11-31)22-8-5-20(6-9-22)25-17-26-27(30-25)28-18-21(29-26)7-4-19-14-23(33-2)16-24(15-19)34-3/h5-6,8-9,14-18H,4,7,10-13H2,1-3H3,(H,28,30)
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM337265
PNG
(2-[2-(3,5-dimethoxyphenyl)ethyl]-6-[4-(4-ethylpipe...)
Show SMILES CCN1CCN(CC1)c1ccc(cc1)-c1cc2nc(CCc3cc(OC)cc(OC)c3)cnc2[nH]1
Show InChI InChI=1S/C28H33N5O2/c1-4-32-11-13-33(14-12-32)23-9-6-21(7-10-23)26-18-27-28(31-26)29-19-22(30-27)8-5-20-15-24(34-2)17-25(16-20)35-3/h6-7,9-10,15-19H,4-5,8,11-14H2,1-3H3,(H,29,31)
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM337265
PNG
(2-[2-(3,5-dimethoxyphenyl)ethyl]-6-[4-(4-ethylpipe...)
Show SMILES CCN1CCN(CC1)c1ccc(cc1)-c1cc2nc(CCc3cc(OC)cc(OC)c3)cnc2[nH]1
Show InChI InChI=1S/C28H33N5O2/c1-4-32-11-13-33(14-12-32)23-9-6-21(7-10-23)26-18-27-28(31-26)29-19-22(30-27)8-5-20-15-24(34-2)17-25(16-20)35-3/h6-7,9-10,15-19H,4-5,8,11-14H2,1-3H3,(H,29,31)
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM337265
PNG
(2-[2-(3,5-dimethoxyphenyl)ethyl]-6-[4-(4-ethylpipe...)
Show SMILES CCN1CCN(CC1)c1ccc(cc1)-c1cc2nc(CCc3cc(OC)cc(OC)c3)cnc2[nH]1
Show InChI InChI=1S/C28H33N5O2/c1-4-32-11-13-33(14-12-32)23-9-6-21(7-10-23)26-18-27-28(31-26)29-19-22(30-27)8-5-20-15-24(34-2)17-25(16-20)35-3/h6-7,9-10,15-19H,4-5,8,11-14H2,1-3H3,(H,29,31)
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM337267
PNG
(2-(3,5-dimethoxyphenethyl)-6-phenyl-5H-pyrrolo[2,3...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccccc2)cc(OC)c1
Show InChI InChI=1S/C22H21N3O2/c1-26-18-10-15(11-19(12-18)27-2)8-9-17-14-23-22-21(24-17)13-20(25-22)16-6-4-3-5-7-16/h3-7,10-14H,8-9H2,1-2H3,(H,23,25)
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM337267
PNG
(2-(3,5-dimethoxyphenethyl)-6-phenyl-5H-pyrrolo[2,3...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccccc2)cc(OC)c1
Show InChI InChI=1S/C22H21N3O2/c1-26-18-10-15(11-19(12-18)27-2)8-9-17-14-23-22-21(24-17)13-20(25-22)16-6-4-3-5-7-16/h3-7,10-14H,8-9H2,1-2H3,(H,23,25)
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM337267
PNG
(2-(3,5-dimethoxyphenethyl)-6-phenyl-5H-pyrrolo[2,3...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccccc2)cc(OC)c1
Show InChI InChI=1S/C22H21N3O2/c1-26-18-10-15(11-19(12-18)27-2)8-9-17-14-23-22-21(24-17)13-20(25-22)16-6-4-3-5-7-16/h3-7,10-14H,8-9H2,1-2H3,(H,23,25)
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM337268
PNG
(6-(2,6-difluorophenyl)-2-(3,5-dimethoxyphenethyl)-...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2c(F)cccc2F)cc(OC)c1
Show InChI InChI=1S/C22H19F2N3O2/c1-28-15-8-13(9-16(10-15)29-2)6-7-14-12-25-22-20(26-14)11-19(27-22)21-17(23)4-3-5-18(21)24/h3-5,8-12H,6-7H2,1-2H3,(H,25,27)
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM337269
PNG
(2-[2-(3,5-dimethoxyphenyl)ethyl]-6-(4-methoxypheny...)
Show SMILES COc1ccc(cc1)-c1cc2nc(CCc3cc(OC)cc(OC)c3)cnc2[nH]1
Show InChI InChI=1S/C23H23N3O3/c1-27-18-8-5-16(6-9-18)21-13-22-23(26-21)24-14-17(25-22)7-4-15-10-19(28-2)12-20(11-15)29-3/h5-6,8-14H,4,7H2,1-3H3,(H,24,26)
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM337269
PNG
(2-[2-(3,5-dimethoxyphenyl)ethyl]-6-(4-methoxypheny...)
Show SMILES COc1ccc(cc1)-c1cc2nc(CCc3cc(OC)cc(OC)c3)cnc2[nH]1
Show InChI InChI=1S/C23H23N3O3/c1-27-18-8-5-16(6-9-18)21-13-22-23(26-21)24-14-17(25-22)7-4-15-10-19(28-2)12-20(11-15)29-3/h5-6,8-14H,4,7H2,1-3H3,(H,24,26)
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM337269
PNG
(2-[2-(3,5-dimethoxyphenyl)ethyl]-6-(4-methoxypheny...)
Show SMILES COc1ccc(cc1)-c1cc2nc(CCc3cc(OC)cc(OC)c3)cnc2[nH]1
Show InChI InChI=1S/C23H23N3O3/c1-27-18-8-5-16(6-9-18)21-13-22-23(26-21)24-14-17(25-22)7-4-15-10-19(28-2)12-20(11-15)29-3/h5-6,8-14H,4,7H2,1-3H3,(H,24,26)
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM337270
PNG
(N-(4-{2-[2-(3,5-dimethoxyphenyl)ethyl]-5H-pyrrolo[...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccc(NC(C)=O)cc2)cc(OC)c1
Show InChI InChI=1S/C24H24N4O3/c1-15(29)26-18-8-5-17(6-9-18)22-13-23-24(28-22)25-14-19(27-23)7-4-16-10-20(30-2)12-21(11-16)31-3/h5-6,8-14H,4,7H2,1-3H3,(H,25,28)(H,26,29)
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM337270
PNG
(N-(4-{2-[2-(3,5-dimethoxyphenyl)ethyl]-5H-pyrrolo[...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccc(NC(C)=O)cc2)cc(OC)c1
Show InChI InChI=1S/C24H24N4O3/c1-15(29)26-18-8-5-17(6-9-18)22-13-23-24(28-22)25-14-19(27-23)7-4-16-10-20(30-2)12-21(11-16)31-3/h5-6,8-14H,4,7H2,1-3H3,(H,25,28)(H,26,29)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM337272
PNG
(4-{2-[2-(3,5-dimethoxyphenyl)ethyl]-5H-pyrrolo[2,3...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccc(cc2)C(=O)N(C)C)cc(OC)c1
Show InChI InChI=1S/C25H26N4O3/c1-29(2)25(30)18-8-6-17(7-9-18)22-14-23-24(28-22)26-15-19(27-23)10-5-16-11-20(31-3)13-21(12-16)32-4/h6-9,11-15H,5,10H2,1-4H3,(H,26,28)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM337272
PNG
(4-{2-[2-(3,5-dimethoxyphenyl)ethyl]-5H-pyrrolo[2,3...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccc(cc2)C(=O)N(C)C)cc(OC)c1
Show InChI InChI=1S/C25H26N4O3/c1-29(2)25(30)18-8-6-17(7-9-18)22-14-23-24(28-22)26-15-19(27-23)10-5-16-11-20(31-3)13-21(12-16)32-4/h6-9,11-15H,5,10H2,1-4H3,(H,26,28)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM337273
PNG
(2-[2-(3,5-dimethoxyphenyl)ethyl]-6-[4-(trifluorome...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccc(cc2)C(F)(F)F)cc(OC)c1
Show InChI InChI=1S/C23H20F3N3O2/c1-30-18-9-14(10-19(11-18)31-2)3-8-17-13-27-22-21(28-17)12-20(29-22)15-4-6-16(7-5-15)23(24,25)26/h4-7,9-13H,3,8H2,1-2H3,(H,27,29)
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM337274
PNG
(2-[2-(3,5-dimethoxyphenyl)ethyl]-6-(2-methylphenyl...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccccc2C)cc(OC)c1
Show InChI InChI=1S/C23H23N3O2/c1-15-6-4-5-7-20(15)21-13-22-23(26-21)24-14-17(25-22)9-8-16-10-18(27-2)12-19(11-16)28-3/h4-7,10-14H,8-9H2,1-3H3,(H,24,26)
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM337275
PNG
(2-{2-[2-(3,5-dimethoxyphenyl)ethyl]-5H-pyrrolo[2,3...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccccc2C#N)cc(OC)c1
Show InChI InChI=1S/C23H20N4O2/c1-28-18-9-15(10-19(11-18)29-2)7-8-17-14-25-23-22(26-17)12-21(27-23)20-6-4-3-5-16(20)13-24/h3-6,9-12,14H,7-8H2,1-2H3,(H,25,27)
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM337275
PNG
(2-{2-[2-(3,5-dimethoxyphenyl)ethyl]-5H-pyrrolo[2,3...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccccc2C#N)cc(OC)c1
Show InChI InChI=1S/C23H20N4O2/c1-28-18-9-15(10-19(11-18)29-2)7-8-17-14-25-23-22(26-17)12-21(27-23)20-6-4-3-5-16(20)13-24/h3-6,9-12,14H,7-8H2,1-2H3,(H,25,27)
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM337276
PNG
(2-[2-(3,5-dimethoxyphenyl)ethyl]-6-[4-(piperidin-1...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccc(CN3CCCCC3)cc2)cc(OC)c1
Show InChI InChI=1S/C28H32N4O2/c1-33-24-14-21(15-25(16-24)34-2)8-11-23-18-29-28-27(30-23)17-26(31-28)22-9-6-20(7-10-22)19-32-12-4-3-5-13-32/h6-7,9-10,14-18H,3-5,8,11-13,19H2,1-2H3,(H,29,31)
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM337276
PNG
(2-[2-(3,5-dimethoxyphenyl)ethyl]-6-[4-(piperidin-1...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccc(CN3CCCCC3)cc2)cc(OC)c1
Show InChI InChI=1S/C28H32N4O2/c1-33-24-14-21(15-25(16-24)34-2)8-11-23-18-29-28-27(30-23)17-26(31-28)22-9-6-20(7-10-22)19-32-12-4-3-5-13-32/h6-7,9-10,14-18H,3-5,8,11-13,19H2,1-2H3,(H,29,31)
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM337276
PNG
(2-[2-(3,5-dimethoxyphenyl)ethyl]-6-[4-(piperidin-1...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccc(CN3CCCCC3)cc2)cc(OC)c1
Show InChI InChI=1S/C28H32N4O2/c1-33-24-14-21(15-25(16-24)34-2)8-11-23-18-29-28-27(30-23)17-26(31-28)22-9-6-20(7-10-22)19-32-12-4-3-5-13-32/h6-7,9-10,14-18H,3-5,8,11-13,19H2,1-2H3,(H,29,31)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM337277
PNG
(2-[2-(3,5-dimethoxyphenyl)ethyl]-6-[4-(methoxymeth...)
Show SMILES COCc1ccc(cc1)-c1cc2nc(CCc3cc(OC)cc(OC)c3)cnc2[nH]1
Show InChI InChI=1S/C24H25N3O3/c1-28-15-16-4-7-18(8-5-16)22-13-23-24(27-22)25-14-19(26-23)9-6-17-10-20(29-2)12-21(11-17)30-3/h4-5,7-8,10-14H,6,9,15H2,1-3H3,(H,25,27)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM337277
PNG
(2-[2-(3,5-dimethoxyphenyl)ethyl]-6-[4-(methoxymeth...)
Show SMILES COCc1ccc(cc1)-c1cc2nc(CCc3cc(OC)cc(OC)c3)cnc2[nH]1
Show InChI InChI=1S/C24H25N3O3/c1-28-15-16-4-7-18(8-5-16)22-13-23-24(27-22)25-14-19(26-23)9-6-17-10-20(29-2)12-21(11-17)30-3/h4-5,7-8,10-14H,6,9,15H2,1-3H3,(H,25,27)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM337277
PNG
(2-[2-(3,5-dimethoxyphenyl)ethyl]-6-[4-(methoxymeth...)
Show SMILES COCc1ccc(cc1)-c1cc2nc(CCc3cc(OC)cc(OC)c3)cnc2[nH]1
Show InChI InChI=1S/C24H25N3O3/c1-28-15-16-4-7-18(8-5-16)22-13-23-24(27-22)25-14-19(26-23)9-6-17-10-20(29-2)12-21(11-17)30-3/h4-5,7-8,10-14H,6,9,15H2,1-3H3,(H,25,27)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM337278
PNG
((4-{2-[2-(3,5-dimethoxyphenyl)ethyl]-5H-pyrrolo[2,...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccc(CO)cc2)cc(OC)c1
Show InChI InChI=1S/C23H23N3O3/c1-28-19-9-16(10-20(11-19)29-2)5-8-18-13-24-23-22(25-18)12-21(26-23)17-6-3-15(14-27)4-7-17/h3-4,6-7,9-13,27H,5,8,14H2,1-2H3,(H,24,26)
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM337278
PNG
((4-{2-[2-(3,5-dimethoxyphenyl)ethyl]-5H-pyrrolo[2,...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccc(CO)cc2)cc(OC)c1
Show InChI InChI=1S/C23H23N3O3/c1-28-19-9-16(10-20(11-19)29-2)5-8-18-13-24-23-22(25-18)12-21(26-23)17-6-3-15(14-27)4-7-17/h3-4,6-7,9-13,27H,5,8,14H2,1-2H3,(H,24,26)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM337278
PNG
((4-{2-[2-(3,5-dimethoxyphenyl)ethyl]-5H-pyrrolo[2,...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccc(CO)cc2)cc(OC)c1
Show InChI InChI=1S/C23H23N3O3/c1-28-19-9-16(10-20(11-19)29-2)5-8-18-13-24-23-22(25-18)12-21(26-23)17-6-3-15(14-27)4-7-17/h3-4,6-7,9-13,27H,5,8,14H2,1-2H3,(H,24,26)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM337279
PNG
((4-{2-[2-(3,5-dimethoxyphenyl)ethyl]-5H-pyrrolo[2,...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccc(CC#N)cc2)cc(OC)c1
Show InChI InChI=1S/C24H22N4O2/c1-29-20-11-17(12-21(13-20)30-2)5-8-19-15-26-24-23(27-19)14-22(28-24)18-6-3-16(4-7-18)9-10-25/h3-4,6-7,11-15H,5,8-9H2,1-2H3,(H,26,28)
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM337279
PNG
((4-{2-[2-(3,5-dimethoxyphenyl)ethyl]-5H-pyrrolo[2,...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccc(CC#N)cc2)cc(OC)c1
Show InChI InChI=1S/C24H22N4O2/c1-29-20-11-17(12-21(13-20)30-2)5-8-19-15-26-24-23(27-19)14-22(28-24)18-6-3-16(4-7-18)9-10-25/h3-4,6-7,11-15H,5,8-9H2,1-2H3,(H,26,28)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM337281
PNG
(4-{2-[2-(3,5-dimethoxyphenyl)ethyl]-5H-pyrrolo[2,3...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccc(cc2)C(O)=O)cc(OC)c1
Show InChI InChI=1S/C23H21N3O4/c1-29-18-9-14(10-19(11-18)30-2)3-8-17-13-24-22-21(25-17)12-20(26-22)15-4-6-16(7-5-15)23(27)28/h4-7,9-13H,3,8H2,1-2H3,(H,24,26)(H,27,28)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM337281
PNG
(4-{2-[2-(3,5-dimethoxyphenyl)ethyl]-5H-pyrrolo[2,3...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccc(cc2)C(O)=O)cc(OC)c1
Show InChI InChI=1S/C23H21N3O4/c1-29-18-9-14(10-19(11-18)30-2)3-8-17-13-24-22-21(25-17)12-20(26-22)15-4-6-16(7-5-15)23(27)28/h4-7,9-13H,3,8H2,1-2H3,(H,24,26)(H,27,28)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM337281
PNG
(4-{2-[2-(3,5-dimethoxyphenyl)ethyl]-5H-pyrrolo[2,3...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccc(cc2)C(O)=O)cc(OC)c1
Show InChI InChI=1S/C23H21N3O4/c1-29-18-9-14(10-19(11-18)30-2)3-8-17-13-24-22-21(25-17)12-20(26-22)15-4-6-16(7-5-15)23(27)28/h4-7,9-13H,3,8H2,1-2H3,(H,24,26)(H,27,28)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM337282
PNG
(2-[2-(3,5-dimethoxyphenyl)ethyl]-6-[6-(4-methylpip...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccc(nc2)N2CCN(C)CC2)cc(OC)c1
Show InChI InChI=1S/C26H30N6O2/c1-31-8-10-32(11-9-31)25-7-5-19(16-27-25)23-15-24-26(30-23)28-17-20(29-24)6-4-18-12-21(33-2)14-22(13-18)34-3/h5,7,12-17H,4,6,8-11H2,1-3H3,(H,28,30)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM337282
PNG
(2-[2-(3,5-dimethoxyphenyl)ethyl]-6-[6-(4-methylpip...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccc(nc2)N2CCN(C)CC2)cc(OC)c1
Show InChI InChI=1S/C26H30N6O2/c1-31-8-10-32(11-9-31)25-7-5-19(16-27-25)23-15-24-26(30-23)28-17-20(29-24)6-4-18-12-21(33-2)14-22(13-18)34-3/h5,7,12-17H,4,6,8-11H2,1-3H3,(H,28,30)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM337283
PNG
(5-{2-[2-(3,5-dimethoxyphenyl)ethyl]-5H-pyrrolo[2,3...)
Show SMILES CNC(O)c1ccc(cn1)-c1cc2nc(CCc3cc(OC)cc(OC)c3)cnc2[nH]1
Show InChI InChI=1S/C23H25N5O3/c1-24-23(29)19-7-5-15(12-25-19)20-11-21-22(28-20)26-13-16(27-21)6-4-14-8-17(30-2)10-18(9-14)31-3/h5,7-13,23-24,29H,4,6H2,1-3H3,(H,26,28)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM337283
PNG
(5-{2-[2-(3,5-dimethoxyphenyl)ethyl]-5H-pyrrolo[2,3...)
Show SMILES CNC(O)c1ccc(cn1)-c1cc2nc(CCc3cc(OC)cc(OC)c3)cnc2[nH]1
Show InChI InChI=1S/C23H25N5O3/c1-24-23(29)19-7-5-15(12-25-19)20-11-21-22(28-20)26-13-16(27-21)6-4-14-8-17(30-2)10-18(9-14)31-3/h5,7-13,23-24,29H,4,6H2,1-3H3,(H,26,28)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM337284
PNG
(2-[2-(3,5-dimethoxyphenyl)ethyl]-6-[5-(morpholin-4...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2cncc(c2)C(=O)N2CCOCC2)cc(OC)c1
Show InChI InChI=1S/C26H27N5O4/c1-33-21-9-17(10-22(12-21)34-2)3-4-20-16-28-25-24(29-20)13-23(30-25)18-11-19(15-27-14-18)26(32)31-5-7-35-8-6-31/h9-16H,3-8H2,1-2H3,(H,28,30)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM337284
PNG
(2-[2-(3,5-dimethoxyphenyl)ethyl]-6-[5-(morpholin-4...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2cncc(c2)C(=O)N2CCOCC2)cc(OC)c1
Show InChI InChI=1S/C26H27N5O4/c1-33-21-9-17(10-22(12-21)34-2)3-4-20-16-28-25-24(29-20)13-23(30-25)18-11-19(15-27-14-18)26(32)31-5-7-35-8-6-31/h9-16H,3-8H2,1-2H3,(H,28,30)
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM337285
PNG
(4-{2-[2-(3,5-dimethoxyphenyl)ethyl]-5H-pyrrolo[2,3...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccc(s2)C(O)=O)cc(OC)c1
Show InChI InChI=1S/C21H19N3O4S/c1-27-14-7-12(8-15(9-14)28-2)3-4-13-11-22-20-17(23-13)10-16(24-20)18-5-6-19(29-18)21(25)26/h5-11H,3-4H2,1-2H3,(H,22,24)(H,25,26)
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM337285
PNG
(4-{2-[2-(3,5-dimethoxyphenyl)ethyl]-5H-pyrrolo[2,3...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccc(s2)C(O)=O)cc(OC)c1
Show InChI InChI=1S/C21H19N3O4S/c1-27-14-7-12(8-15(9-14)28-2)3-4-13-11-22-20-17(23-13)10-16(24-20)18-5-6-19(29-18)21(25)26/h5-11H,3-4H2,1-2H3,(H,22,24)(H,25,26)
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM337286
PNG
(5-{2-[2-(3,5-dimethoxyphenyl)ethyl]-5H-pyrrolo[2,3...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2cnc(nc2)N(C)C)cc(OC)c1
Show InChI InChI=1S/C22H24N6O2/c1-28(2)22-24-11-15(12-25-22)19-10-20-21(27-19)23-13-16(26-20)6-5-14-7-17(29-3)9-18(8-14)30-4/h7-13H,5-6H2,1-4H3,(H,23,27)
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM337288
PNG
(2-[2-(3,5-dimethoxyphenyl)ethyl]-6-[4-(1-methylpip...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccc(cc2)C2CCN(C)CC2)cc(OC)c1
Show InChI InChI=1S/C28H32N4O2/c1-32-12-10-21(11-13-32)20-5-7-22(8-6-20)26-17-27-28(31-26)29-18-23(30-27)9-4-19-14-24(33-2)16-25(15-19)34-3/h5-8,14-18,21H,4,9-13H2,1-3H3,(H,29,31)
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM337288
PNG
(2-[2-(3,5-dimethoxyphenyl)ethyl]-6-[4-(1-methylpip...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccc(cc2)C2CCN(C)CC2)cc(OC)c1
Show InChI InChI=1S/C28H32N4O2/c1-32-12-10-21(11-13-32)20-5-7-22(8-6-20)26-17-27-28(31-26)29-18-23(30-27)9-4-19-14-24(33-2)16-25(15-19)34-3/h5-8,14-18,21H,4,9-13H2,1-3H3,(H,29,31)
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM337288
PNG
(2-[2-(3,5-dimethoxyphenyl)ethyl]-6-[4-(1-methylpip...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)-c2ccc(cc2)C2CCN(C)CC2)cc(OC)c1
Show InChI InChI=1S/C28H32N4O2/c1-32-12-10-21(11-13-32)20-5-7-22(8-6-20)26-17-27-28(31-26)29-18-23(30-27)9-4-19-14-24(33-2)16-25(15-19)34-3/h5-8,14-18,21H,4,9-13H2,1-3H3,(H,29,31)
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM337290
PNG
(2-[2-(3,5-dimethoxyphenyl)ethyl]-6-(1-methyl-1,2,3...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)C2=CCN(C)CC2)cc(OC)c1
Show InChI InChI=1S/C22H26N4O2/c1-26-8-6-16(7-9-26)20-13-21-22(25-20)23-14-17(24-21)5-4-15-10-18(27-2)12-19(11-15)28-3/h6,10-14H,4-5,7-9H2,1-3H3,(H,23,25)
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 2


(Homo sapiens (Human))
BDBM337290
PNG
(2-[2-(3,5-dimethoxyphenyl)ethyl]-6-(1-methyl-1,2,3...)
Show SMILES COc1cc(CCc2cnc3[nH]c(cc3n2)C2=CCN(C)CC2)cc(OC)c1
Show InChI InChI=1S/C22H26N4O2/c1-26-8-6-16(7-9-26)20-13-21-22(25-20)23-14-17(24-21)5-4-15-10-18(27-2)12-19(11-15)28-3/h6,10-14H,4-5,7-9H2,1-3H3,(H,23,25)
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM337300
PNG
(3-{2-[2-(3,5-dimethoxyphenyl)ethyl]-5H-pyrrolo[2,3...)
Show SMILES CCN(CC)CC#Cc1cc2nc(CCc3cc(OC)cc(OC)c3)cnc2[nH]1
Show InChI InChI=1S/C23H28N4O2/c1-5-27(6-2)11-7-8-18-14-22-23(26-18)24-16-19(25-22)10-9-17-12-20(28-3)15-21(13-17)29-4/h12-16H,5-6,9-11H2,1-4H3,(H,24,26)
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The inhibitor potency of compounds was measured in an enzyme assay that measures peptide phosphorylation using FRET measurements to detect product fo...


US Patent US9745311 (2017)

More data for this
Ligand-Target Pair
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