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Compile Data Set for Download or QSAR

Found 324 hits Enz. Inhib. hit(s) with all data for entry = 2080   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM352020
PNG
((3R,4R,5S)-3-Amino-1-{3-[({6-[2,6-difluoro-4-(3-hy...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)C1(O)CCOC1
Show InChI InChI=1/C27H30F3N5O3/c1-15-12-35(13-21(31)26(15)36)23-4-6-32-11-22(23)33-10-17-2-3-18(28)25(34-17)24-19(29)8-16(9-20(24)30)27(37)5-7-38-14-27/h2-4,6,8-9,11,15,21,26,33,36-37H,5,7,10,12-14,31H2,1H3/t15-,21+,26+,27?/s2
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Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM352020
PNG
((3R,4R,5S)-3-Amino-1-{3-[({6-[2,6-difluoro-4-(3-hy...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)C1(O)CCOC1
Show InChI InChI=1/C27H30F3N5O3/c1-15-12-35(13-21(31)26(15)36)23-4-6-32-11-22(23)33-10-17-2-3-18(28)25(34-17)24-19(29)8-16(9-20(24)30)27(37)5-7-38-14-27/h2-4,6,8-9,11,15,21,26,33,36-37H,5,7,10,12-14,31H2,1H3/t15-,21+,26+,27?/s2
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Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM352026
PNG
((3R,4R,5S)-3-Amino-1-(3-(((6-(2,6-difluoro-4-(1-hy...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)C1(O)CCC1
Show InChI InChI=1/C27H30F3N5O2/c1-15-13-35(14-21(31)26(15)36)23-5-8-32-12-22(23)33-11-17-3-4-18(28)25(34-17)24-19(29)9-16(10-20(24)30)27(37)6-2-7-27/h3-5,8-10,12,15,21,26,33,36-37H,2,6-7,11,13-14,31H2,1H3/t15-,21+,26+/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM352026
PNG
((3R,4R,5S)-3-Amino-1-(3-(((6-(2,6-difluoro-4-(1-hy...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)C1(O)CCC1
Show InChI InChI=1/C27H30F3N5O2/c1-15-13-35(14-21(31)26(15)36)23-5-8-32-12-22(23)33-11-17-3-4-18(28)25(34-17)24-19(29)9-16(10-20(24)30)27(37)6-2-7-27/h3-5,8-10,12,15,21,26,33,36-37H,2,6-7,11,13-14,31H2,1H3/t15-,21+,26+/s2
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Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM352030
PNG
((3R,4R,5S)-3-Amino-1-(3-(((6-(2,6-difluoro-4-(4-hy...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)C1(O)CCOCC1
Show InChI InChI=1/C28H32F3N5O3/c1-16-14-36(15-22(32)27(16)37)24-4-7-33-13-23(24)34-12-18-2-3-19(29)26(35-18)25-20(30)10-17(11-21(25)31)28(38)5-8-39-9-6-28/h2-4,7,10-11,13,16,22,27,34,37-38H,5-6,8-9,12,14-15,32H2,1H3/t16-,22+,27+/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM352030
PNG
((3R,4R,5S)-3-Amino-1-(3-(((6-(2,6-difluoro-4-(4-hy...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)C1(O)CCOCC1
Show InChI InChI=1/C28H32F3N5O3/c1-16-14-36(15-22(32)27(16)37)24-4-7-33-13-23(24)34-12-18-2-3-19(29)26(35-18)25-20(30)10-17(11-21(25)31)28(38)5-8-39-9-6-28/h2-4,7,10-11,13,16,22,27,34,37-38H,5-6,8-9,12,14-15,32H2,1H3/t16-,22+,27+/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM352031
PNG
(3-(4-{6-[({4-[(3S,5R)-3-Amino-5-methylpiperidin-1-...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)C1(O)CCOC1
Show InChI InChI=1/C27H30F3N5O2/c1-16-8-18(31)14-35(13-16)24-4-6-32-12-23(24)33-11-19-2-3-20(28)26(34-19)25-21(29)9-17(10-22(25)30)27(36)5-7-37-15-27/h2-4,6,9-10,12,16,18,33,36H,5,7-8,11,13-15,31H2,1H3/t16-,18+,27?/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM352031
PNG
(3-(4-{6-[({4-[(3S,5R)-3-Amino-5-methylpiperidin-1-...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)C1(O)CCOC1
Show InChI InChI=1/C27H30F3N5O2/c1-16-8-18(31)14-35(13-16)24-4-6-32-12-23(24)33-11-19-2-3-20(28)26(34-19)25-21(29)9-17(10-22(25)30)27(36)5-7-37-15-27/h2-4,6,9-10,12,16,18,33,36H,5,7-8,11,13-15,31H2,1H3/t16-,18+,27?/s2
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Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM352033
PNG
(1-(4-(6-((4-((3S,5R)-3-Amino-5-methylpiperidin-1-y...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)C1(O)CCC1
Show InChI InChI=1/C27H30F3N5O/c1-16-9-18(31)15-35(14-16)24-5-8-32-13-23(24)33-12-19-3-4-20(28)26(34-19)25-21(29)10-17(11-22(25)30)27(36)6-2-7-27/h3-5,8,10-11,13,16,18,33,36H,2,6-7,9,12,14-15,31H2,1H3/t16-,18+/s2
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Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM352033
PNG
(1-(4-(6-((4-((3S,5R)-3-Amino-5-methylpiperidin-1-y...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)C1(O)CCC1
Show InChI InChI=1/C27H30F3N5O/c1-16-9-18(31)15-35(14-16)24-5-8-32-13-23(24)33-12-19-3-4-20(28)26(34-19)25-21(29)10-17(11-22(25)30)27(36)6-2-7-27/h3-5,8,10-11,13,16,18,33,36H,2,6-7,9,12,14-15,31H2,1H3/t16-,18+/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM352034
PNG
(4-(4-(6-((4-((3S,5R)-3-Amino-5-methylpiperidin-1-y...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)C1(O)CCOCC1
Show InChI InChI=1/C28H32F3N5O2/c1-17-10-19(32)16-36(15-17)25-4-7-33-14-24(25)34-13-20-2-3-21(29)27(35-20)26-22(30)11-18(12-23(26)31)28(37)5-8-38-9-6-28/h2-4,7,11-12,14,17,19,34,37H,5-6,8-10,13,15-16,32H2,1H3/t17-,19+/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM352034
PNG
(4-(4-(6-((4-((3S,5R)-3-Amino-5-methylpiperidin-1-y...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)C1(O)CCOCC1
Show InChI InChI=1/C28H32F3N5O2/c1-17-10-19(32)16-36(15-17)25-4-7-33-14-24(25)34-13-20-2-3-21(29)27(35-20)26-22(30)11-18(12-23(26)31)28(37)5-8-38-9-6-28/h2-4,7,11-12,14,17,19,34,37H,5-6,8-10,13,15-16,32H2,1H3/t17-,19+/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM352075
PNG
(1-(4-{6-[({4-[(3S,5R)-3-Amino-5-(trifluoromethyl)p...)
Show SMILES N[C@H]1C[C@H](CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)C1(O)CCC1)C(F)(F)F
Show InChI InChI=1/C27H27F6N5O/c28-19-3-2-18(37-25(19)24-20(29)9-15(10-21(24)30)26(39)5-1-6-26)11-36-22-12-35-7-4-23(22)38-13-16(27(31,32)33)8-17(34)14-38/h2-4,7,9-10,12,16-17,36,39H,1,5-6,8,11,13-14,34H2/t16-,17+/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM352075
PNG
(1-(4-{6-[({4-[(3S,5R)-3-Amino-5-(trifluoromethyl)p...)
Show SMILES N[C@H]1C[C@H](CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)C1(O)CCC1)C(F)(F)F
Show InChI InChI=1/C27H27F6N5O/c28-19-3-2-18(37-25(19)24-20(29)9-15(10-21(24)30)26(39)5-1-6-26)11-36-22-12-35-7-4-23(22)38-13-16(27(31,32)33)8-17(34)14-38/h2-4,7,9-10,12,16-17,36,39H,1,5-6,8,11,13-14,34H2/t16-,17+/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM352076
PNG
((3R,4R,5S)-3-Amino-1-{3-[({6-[2,6-difluoro-4-(1-hy...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)C1(O)CC1
Show InChI InChI=1/C26H28F3N5O2/c1-14-12-34(13-20(30)25(14)35)22-4-7-31-11-21(22)32-10-16-2-3-17(27)24(33-16)23-18(28)8-15(9-19(23)29)26(36)5-6-26/h2-4,7-9,11,14,20,25,32,35-36H,5-6,10,12-13,30H2,1H3/t14-,20+,25+/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM352076
PNG
((3R,4R,5S)-3-Amino-1-{3-[({6-[2,6-difluoro-4-(1-hy...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)C1(O)CC1
Show InChI InChI=1/C26H28F3N5O2/c1-14-12-34(13-20(30)25(14)35)22-4-7-31-11-21(22)32-10-16-2-3-17(27)24(33-16)23-18(28)8-15(9-19(23)29)26(36)5-6-26/h2-4,7-9,11,14,20,25,32,35-36H,5-6,10,12-13,30H2,1H3/t14-,20+,25+/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM352077
PNG
((3R,4R,5S)-3-Amino-1-(3-(((6-(2,6-difluoro-3-(1-hy...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)ccc(c1F)C1(O)CC1
Show InChI InChI=1/C26H28F3N5O2/c1-14-12-34(13-19(30)25(14)35)21-6-9-31-11-20(21)32-10-15-2-4-18(28)24(33-15)22-17(27)5-3-16(23(22)29)26(36)7-8-26/h2-6,9,11,14,19,25,32,35-36H,7-8,10,12-13,30H2,1H3/t14-,19+,25+/s2
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Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM352077
PNG
((3R,4R,5S)-3-Amino-1-(3-(((6-(2,6-difluoro-3-(1-hy...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)ccc(c1F)C1(O)CC1
Show InChI InChI=1/C26H28F3N5O2/c1-14-12-34(13-19(30)25(14)35)21-6-9-31-11-20(21)32-10-15-2-4-18(28)24(33-15)22-17(27)5-3-16(23(22)29)26(36)7-8-26/h2-6,9,11,14,19,25,32,35-36H,7-8,10,12-13,30H2,1H3/t14-,19+,25+/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM352078
PNG
(1-(4-{6-[({4-[(3S,5R)-3-Amino-5-methylpiperidin-1-...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)C1(O)CC1
Show InChI InChI=1/C26H28F3N5O/c1-15-8-17(30)14-34(13-15)23-4-7-31-12-22(23)32-11-18-2-3-19(27)25(33-18)24-20(28)9-16(10-21(24)29)26(35)5-6-26/h2-4,7,9-10,12,15,17,32,35H,5-6,8,11,13-14,30H2,1H3/t15-,17+/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM352078
PNG
(1-(4-{6-[({4-[(3S,5R)-3-Amino-5-methylpiperidin-1-...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)C1(O)CC1
Show InChI InChI=1/C26H28F3N5O/c1-15-8-17(30)14-34(13-15)23-4-7-31-12-22(23)32-11-18-2-3-19(27)25(33-18)24-20(28)9-16(10-21(24)29)26(35)5-6-26/h2-4,7,9-10,12,15,17,32,35H,5-6,8,11,13-14,30H2,1H3/t15-,17+/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM352079
PNG
(1-(3-(6-((4-((3S,5R)-3-Amino-5-methylpiperidin-1-y...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)ccc(c1F)C1(O)CC1
Show InChI InChI=1/C26H28F3N5O/c1-15-10-16(30)14-34(13-15)22-6-9-31-12-21(22)32-11-17-2-4-20(28)25(33-17)23-19(27)5-3-18(24(23)29)26(35)7-8-26/h2-6,9,12,15-16,32,35H,7-8,10-11,13-14,30H2,1H3/t15-,16+/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM352079
PNG
(1-(3-(6-((4-((3S,5R)-3-Amino-5-methylpiperidin-1-y...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)ccc(c1F)C1(O)CC1
Show InChI InChI=1/C26H28F3N5O/c1-15-10-16(30)14-34(13-15)22-6-9-31-12-21(22)32-11-17-2-4-20(28)25(33-17)23-19(27)5-3-18(24(23)29)26(35)7-8-26/h2-6,9,12,15-16,32,35H,7-8,10-11,13-14,30H2,1H3/t15-,16+/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM352080
PNG
((3R,4R,5S)-3-Amino-1-{3-[({6-[2,6-difluoro-4-(2-hy...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(CC(C)(C)O)cc1F
Show InChI InChI=1/C27H32F3N5O2/c1-15-13-35(14-21(31)26(15)36)23-6-7-32-12-22(23)33-11-17-4-5-18(28)25(34-17)24-19(29)8-16(9-20(24)30)10-27(2,3)37/h4-9,12,15,21,26,33,36-37H,10-11,13-14,31H2,1-3H3/t15-,21+,26+/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM352080
PNG
((3R,4R,5S)-3-Amino-1-{3-[({6-[2,6-difluoro-4-(2-hy...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(CC(C)(C)O)cc1F
Show InChI InChI=1/C27H32F3N5O2/c1-15-13-35(14-21(31)26(15)36)23-6-7-32-12-22(23)33-11-17-4-5-18(28)25(34-17)24-19(29)8-16(9-20(24)30)10-27(2,3)37/h4-9,12,15,21,26,33,36-37H,10-11,13-14,31H2,1-3H3/t15-,21+,26+/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM352081
PNG
(1-(4-{6-[({4-[(3S,5R)-3-Amino-5-methylpiperidin-1-...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(CC(C)(C)O)cc1F
Show InChI InChI=1/C27H32F3N5O/c1-16-8-18(31)15-35(14-16)24-6-7-32-13-23(24)33-12-19-4-5-20(28)26(34-19)25-21(29)9-17(10-22(25)30)11-27(2,3)36/h4-7,9-10,13,16,18,33,36H,8,11-12,14-15,31H2,1-3H3/t16-,18+/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM352081
PNG
(1-(4-{6-[({4-[(3S,5R)-3-Amino-5-methylpiperidin-1-...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(CC(C)(C)O)cc1F
Show InChI InChI=1/C27H32F3N5O/c1-16-8-18(31)15-35(14-16)24-6-7-32-13-23(24)33-12-19-4-5-20(28)26(34-19)25-21(29)9-17(10-22(25)30)11-27(2,3)36/h4-7,9-10,13,16,18,33,36H,8,11-12,14-15,31H2,1-3H3/t16-,18+/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM352082
PNG
((3R,4R,5S)-3-Amino-1-[3-({[6-(2,6-difluorophenyl)-...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cccc1F
Show InChI InChI=1/C23H24F3N5O/c1-13-11-31(12-18(27)23(13)32)20-7-8-28-10-19(20)29-9-14-5-6-17(26)22(30-14)21-15(24)3-2-4-16(21)25/h2-8,10,13,18,23,29,32H,9,11-12,27H2,1H3/t13-,18+,23+/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM352082
PNG
((3R,4R,5S)-3-Amino-1-[3-({[6-(2,6-difluorophenyl)-...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cccc1F
Show InChI InChI=1/C23H24F3N5O/c1-13-11-31(12-18(27)23(13)32)20-7-8-28-10-19(20)29-9-14-5-6-17(26)22(30-14)21-15(24)3-2-4-16(21)25/h2-8,10,13,18,23,29,32H,9,11-12,27H2,1H3/t13-,18+,23+/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM352083
PNG
((3R,4R,5S)-3-Amino-1-(3-(((5-fluoro-6-(2-fluoro-6-...)
Show SMILES COc1cccc(F)c1-c1nc(CNc2cnccc2N2C[C@H](C)[C@@H](O)[C@H](N)C2)ccc1F
Show InChI InChI=1/C24H27F2N5O2/c1-14-12-31(13-18(27)24(14)32)20-8-9-28-11-19(20)29-10-15-6-7-17(26)23(30-15)22-16(25)4-3-5-21(22)33-2/h3-9,11,14,18,24,29,32H,10,12-13,27H2,1-2H3/t14-,18+,24+/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM352083
PNG
((3R,4R,5S)-3-Amino-1-(3-(((5-fluoro-6-(2-fluoro-6-...)
Show SMILES COc1cccc(F)c1-c1nc(CNc2cnccc2N2C[C@H](C)[C@@H](O)[C@H](N)C2)ccc1F
Show InChI InChI=1/C24H27F2N5O2/c1-14-12-31(13-18(27)24(14)32)20-8-9-28-11-19(20)29-10-15-6-7-17(26)23(30-15)22-16(25)4-3-5-21(22)33-2/h3-9,11,14,18,24,29,32H,10,12-13,27H2,1-2H3/t14-,18+,24+/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM352084
PNG
((3R,4R,5S)-3-Amino-5-methyl-1-(3-(((3,3′,5&#...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cncc1F
Show InChI InChI=1/C22H23F3N6O/c1-12-10-31(11-17(26)22(12)32)19-4-5-27-9-18(19)29-6-13-2-3-14(23)21(30-13)20-15(24)7-28-8-16(20)25/h2-5,7-9,12,17,22,29,32H,6,10-11,26H2,1H3/t12-,17+,22+/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM352084
PNG
((3R,4R,5S)-3-Amino-5-methyl-1-(3-(((3,3′,5&#...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cncc1F
Show InChI InChI=1/C22H23F3N6O/c1-12-10-31(11-17(26)22(12)32)19-4-5-27-9-18(19)29-6-13-2-3-14(23)21(30-13)20-15(24)7-28-8-16(20)25/h2-5,7-9,12,17,22,29,32H,6,10-11,26H2,1H3/t12-,17+,22+/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM352085
PNG
(2-(6-((4-((3R,4R,5S)-3-Amino-4-hydroxy-5-methylpip...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cccc1C#N
Show InChI InChI=1/C24H24F2N6O/c1-14-12-32(13-19(28)24(14)33)21-7-8-29-11-20(21)30-10-16-5-6-18(26)23(31-16)22-15(9-27)3-2-4-17(22)25/h2-8,11,14,19,24,30,33H,10,12-13,28H2,1H3/t14-,19+,24+/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM352085
PNG
(2-(6-((4-((3R,4R,5S)-3-Amino-4-hydroxy-5-methylpip...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cccc1C#N
Show InChI InChI=1/C24H24F2N6O/c1-14-12-32(13-19(28)24(14)33)21-7-8-29-11-20(21)30-10-16-5-6-18(26)23(31-16)22-15(9-27)3-2-4-17(22)25/h2-8,11,14,19,24,30,33H,10,12-13,28H2,1H3/t14-,19+,24+/s2
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Incyte Corporation

US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM352086
PNG
((3R,4R,5S)-3-Amino-1-(3-(((5-fluoro-6-(2-fluorophe...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NCc1ccc(F)c(n1)-c1ccccc1F
Show InChI InChI=1/C23H25F2N5O/c1-14-12-30(13-19(26)23(14)31)21-8-9-27-11-20(21)28-10-15-6-7-18(25)22(29-15)16-4-2-3-5-17(16)24/h2-9,11,14,19,23,28,31H,10,12-13,26H2,1H3/t14-,19+,23+/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM352086
PNG
((3R,4R,5S)-3-Amino-1-(3-(((5-fluoro-6-(2-fluorophe...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NCc1ccc(F)c(n1)-c1ccccc1F
Show InChI InChI=1/C23H25F2N5O/c1-14-12-30(13-19(26)23(14)31)21-8-9-27-11-20(21)28-10-15-6-7-18(25)22(29-15)16-4-2-3-5-17(16)24/h2-9,11,14,19,23,28,31H,10,12-13,26H2,1H3/t14-,19+,23+/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM352087
PNG
(4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]-N-{[6-(...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cccc1F
Show InChI InChI=1/C23H24F3N5/c1-14-9-15(27)13-31(12-14)21-7-8-28-11-20(21)29-10-16-5-6-19(26)23(30-16)22-17(24)3-2-4-18(22)25/h2-8,11,14-15,29H,9-10,12-13,27H2,1H3/t14-,15+/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM352087
PNG
(4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]-N-{[6-(...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cccc1F
Show InChI InChI=1/C23H24F3N5/c1-14-9-15(27)13-31(12-14)21-7-8-28-11-20(21)29-10-16-5-6-19(26)23(30-16)22-17(24)3-2-4-18(22)25/h2-8,11,14-15,29H,9-10,12-13,27H2,1H3/t14-,15+/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM352088
PNG
(4-((3S,5R)-3-Amino-5-methylpiperidin-1-yl)-N-((5-f...)
Show SMILES COc1cccc(F)c1-c1nc(CNc2cnccc2N2C[C@H](C)C[C@H](N)C2)ccc1F
Show InChI InChI=1/C24H27F2N5O/c1-15-10-16(27)14-31(13-15)21-8-9-28-12-20(21)29-11-17-6-7-19(26)24(30-17)23-18(25)4-3-5-22(23)32-2/h3-9,12,15-16,29H,10-11,13-14,27H2,1-2H3/t15-,16+/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM352089
PNG
(4-((3S,5R)-3-Amino-5-methylpiperidin-1-yl)-N-((3,3...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cncc1F
Show InChI InChI=1/C22H23F3N6/c1-13-6-14(26)12-31(11-13)20-4-5-27-10-19(20)29-7-15-2-3-16(23)22(30-15)21-17(24)8-28-9-18(21)25/h2-5,8-10,13-14,29H,6-7,11-12,26H2,1H3/t13-,14+/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM352089
PNG
(4-((3S,5R)-3-Amino-5-methylpiperidin-1-yl)-N-((3,3...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cncc1F
Show InChI InChI=1/C22H23F3N6/c1-13-6-14(26)12-31(11-13)20-4-5-27-10-19(20)29-7-15-2-3-16(23)22(30-15)21-17(24)8-28-9-18(21)25/h2-5,8-10,13-14,29H,6-7,11-12,26H2,1H3/t13-,14+/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM352090
PNG
(2-(6-((4-((3S,5R)-3-Amino-5-methylpiperidin-1-yl)p...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cccc1C#N
Show InChI InChI=1/C24H24F2N6/c1-15-9-17(28)14-32(13-15)22-7-8-29-12-21(22)30-11-18-5-6-20(26)24(31-18)23-16(10-27)3-2-4-19(23)25/h2-8,12,15,17,30H,9,11,13-14,28H2,1H3/t15-,17+/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM352090
PNG
(2-(6-((4-((3S,5R)-3-Amino-5-methylpiperidin-1-yl)p...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cccc1C#N
Show InChI InChI=1/C24H24F2N6/c1-15-9-17(28)14-32(13-15)22-7-8-29-12-21(22)30-11-18-5-6-20(26)24(31-18)23-16(10-27)3-2-4-19(23)25/h2-8,12,15,17,30H,9,11,13-14,28H2,1H3/t15-,17+/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM352092
PNG
(4-((3S,5R)-3-Amino-5-methylpiperidin-1-yl)-N-((5-f...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1ccccc1F
Show InChI InChI=1/C23H25F2N5/c1-15-10-16(26)14-30(13-15)22-8-9-27-12-21(22)28-11-17-6-7-20(25)23(29-17)18-4-2-3-5-19(18)24/h2-9,12,15-16,28H,10-11,13-14,26H2,1H3/t15-,16+/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM352092
PNG
(4-((3S,5R)-3-Amino-5-methylpiperidin-1-yl)-N-((5-f...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1ccccc1F
Show InChI InChI=1/C23H25F2N5/c1-15-10-16(26)14-30(13-15)22-8-9-27-12-21(22)28-11-17-6-7-20(25)23(29-17)18-4-2-3-5-19(18)24/h2-9,12,15-16,28H,10-11,13-14,26H2,1H3/t15-,16+/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM352093
PNG
(2-(4-{6-[({4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methy...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)C(C)(C)C#N
Show InChI InChI=1/C27H29F3N6O/c1-15-12-36(13-21(32)26(15)37)23-6-7-33-11-22(23)34-10-17-4-5-18(28)25(35-17)24-19(29)8-16(9-20(24)30)27(2,3)14-31/h4-9,11,15,21,26,34,37H,10,12-13,32H2,1-3H3/t15-,21+,26+/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM352093
PNG
(2-(4-{6-[({4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methy...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)C(C)(C)C#N
Show InChI InChI=1/C27H29F3N6O/c1-15-12-36(13-21(32)26(15)37)23-6-7-33-11-22(23)34-10-17-4-5-18(28)25(35-17)24-19(29)8-16(9-20(24)30)27(2,3)14-31/h4-9,11,15,21,26,34,37H,10,12-13,32H2,1-3H3/t15-,21+,26+/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM352094
PNG
(2-(4-{6-[({4-[(3S,5R)-3-Amino-5-methylpiperidin-1-...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)C(C)(C)C#N
Show InChI InChI=1/C27H29F3N6/c1-16-8-18(32)14-36(13-16)24-6-7-33-12-23(24)34-11-19-4-5-20(28)26(35-19)25-21(29)9-17(10-22(25)30)27(2,3)15-31/h4-7,9-10,12,16,18,34H,8,11,13-14,32H2,1-3H3/t16-,18+/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM352094
PNG
(2-(4-{6-[({4-[(3S,5R)-3-Amino-5-methylpiperidin-1-...)
Show SMILES C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)C(C)(C)C#N
Show InChI InChI=1/C27H29F3N6/c1-16-8-18(32)14-36(13-16)24-6-7-33-12-23(24)34-11-19-4-5-20(28)26(35-19)25-21(29)9-17(10-22(25)30)27(2,3)15-31/h4-7,9-10,12,16,18,34H,8,11,13-14,32H2,1-3H3/t16-,18+/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM352095
PNG
((3R,4R,5S)-3-Amino-5-methyl-1-(3-{[(2′,6,6&#...)
Show SMILES C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cccc1F
Show InChI InChI=1/C23H24F3N5O/c1-13-11-31(12-18(27)23(13)32)20-7-8-28-10-19(20)29-9-14-5-6-17(26)22(30-14)21-15(24)3-2-4-16(21)25/h2-8,10,13,18,23,29,32H,9,11-12,27H2,1H3/t13-,18+,23+/s2
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US Patent


Assay Description
Pim-1 and Pim-3 kinase assays-20 μL reactions were run in white 384 well polystyrene plates dotted with 0.8 μL compound/DMSO in the assay b...


US Patent US9802918 (2017)


Article DOI: 10.1021/jm031057+
BindingDB Entry DOI: 10.7270/Q2F47R9T
More data for this
Ligand-Target Pair
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