Compile Data Set for Download or QSAR
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Found 15 Enz. Inhib. hit(s) with all data for assayid = 1 entry = 2023
TargetSerine protease 1(Bos taurus (bovine))
Max-Planck-Institut Fuer Biochemie

LigandPNGBDBM16175(CHEMBL108468 | UKI-1 | ethyl 4-(3-carbamimidoyl-N-...)
Affinity DataKi:  37nM ΔG°:  -42.4kJ/molepH: 8.0 T: 2°CAssay Description:The measurements were carried out on a microplate reader. Two concentrations of the substrate and five concentrations of the inhibitor were used in t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Max-Planck-Institut Fuer Biochemie

LigandPNGBDBM16175(CHEMBL108468 | UKI-1 | ethyl 4-(3-carbamimidoyl-N-...)
Affinity DataKi:  410nM ΔG°:  -36.5kJ/molepH: 8.0 T: 2°CAssay Description:The measurements were carried out on a microplate reader. Two concentrations of the substrate and five concentrations of the inhibitor were used in t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Max-Planck-Institut Fuer Biochemie

LigandPNGBDBM16174(3-[3-(4-beta-alanylpiperazin-1-yl)-3-oxo-2-({[2,4,...)
Affinity DataKi:  600nM ΔG°:  -35.5kJ/molepH: 8.0 T: 2°CAssay Description:The measurements were carried out on a microplate reader. Two concentrations of the substrate and five concentrations of the inhibitor were used in t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Max-Planck-Institut Fuer Biochemie

LigandPNGBDBM16174(3-[3-(4-beta-alanylpiperazin-1-yl)-3-oxo-2-({[2,4,...)
Affinity DataKi:  640nM ΔG°:  -35.4kJ/molepH: 8.0 T: 2°CAssay Description:The measurements were carried out on a microplate reader. Two concentrations of the substrate and five concentrations of the inhibitor were used in t...More data for this Ligand-Target Pair
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Max-Planck-Institut Fuer Biochemie

LigandPNGBDBM16176(3-(1-adamantyl)-1-[(4-carbamimidamidophenyl)methyl...)
Affinity DataKi:  2.40E+3nM ΔG°:  -32.1kJ/molepH: 8.0 T: 2°CAssay Description:The measurements were carried out on a microplate reader. Two concentrations of the substrate and five concentrations of the inhibitor were used in t...More data for this Ligand-Target Pair
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Max-Planck-Institut Fuer Biochemie

LigandPNGBDBM16175(CHEMBL108468 | UKI-1 | ethyl 4-(3-carbamimidoyl-N-...)
Affinity DataKi:  4.90E+3nM ΔG°:  -30.3kJ/molepH: 8.0 T: 2°CAssay Description:The measurements were carried out on a microplate reader. Two concentrations of the substrate and five concentrations of the inhibitor were used in t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Max-Planck-Institut Fuer Biochemie

LigandPNGBDBM16173(3,5-diamino-6-chloro-N-(diaminomethylene)pyrazinam...)
Affinity DataKi:  5.30E+3nM ΔG°:  -30.1kJ/molepH: 8.0 T: 2°CAssay Description:The measurements were carried out on a microplate reader. Two concentrations of the substrate and five concentrations of the inhibitor were used in t...More data for this Ligand-Target Pair
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Max-Planck-Institut Fuer Biochemie

LigandPNGBDBM16174(3-[3-(4-beta-alanylpiperazin-1-yl)-3-oxo-2-({[2,4,...)
Affinity DataKi:  8.70E+3nM ΔG°:  -28.9kJ/molepH: 8.0 T: 2°CAssay Description:The measurements were carried out on a microplate reader. Two concentrations of the substrate and five concentrations of the inhibitor were used in t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Max-Planck-Institut Fuer Biochemie

LigandPNGBDBM16173(3,5-diamino-6-chloro-N-(diaminomethylene)pyrazinam...)
Affinity DataKi:  3.20E+4nM ΔG°:  -25.7kJ/molepH: 8.0 T: 2°CAssay Description:The measurements were carried out on a microplate reader. Two concentrations of the substrate and five concentrations of the inhibitor were used in t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Max-Planck-Institut Fuer Biochemie

LigandPNGBDBM772(Benzamidine | CHEMBL79897 | [amino(phenyl)methylid...)
Affinity DataKi:  3.90E+4nM ΔG°:  -25.2kJ/molepH: 8.0 T: 2°CAssay Description:The measurements were carried out on a microplate reader. Two concentrations of the substrate and five concentrations of the inhibitor were used in t...More data for this Ligand-Target Pair
TargetSerine protease 1(Bos taurus (bovine))
Max-Planck-Institut Fuer Biochemie

LigandPNGBDBM16176(3-(1-adamantyl)-1-[(4-carbamimidamidophenyl)methyl...)
Affinity DataKi:  4.60E+4nM ΔG°:  -24.8kJ/molepH: 8.0 T: 2°CAssay Description:The measurements were carried out on a microplate reader. Two concentrations of the substrate and five concentrations of the inhibitor were used in t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Max-Planck-Institut Fuer Biochemie

LigandPNGBDBM772(Benzamidine | CHEMBL79897 | [amino(phenyl)methylid...)
Affinity DataKi:  1.80E+5nM ΔG°:  -21.4kJ/molepH: 8.0 T: 2°CAssay Description:The measurements were carried out on a microplate reader. Two concentrations of the substrate and five concentrations of the inhibitor were used in t...More data for this Ligand-Target Pair
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Max-Planck-Institut Fuer Biochemie

LigandPNGBDBM772(Benzamidine | CHEMBL79897 | [amino(phenyl)methylid...)
Affinity DataKi: >1.00E+6nM ΔG°: >-17.1kJ/molepH: 8.0 T: 2°CAssay Description:The measurements were carried out on a microplate reader. Two concentrations of the substrate and five concentrations of the inhibitor were used in t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetTissue-type plasminogen activator(Homo sapiens (Human))
Max-Planck-Institut Fuer Biochemie

LigandPNGBDBM16176(3-(1-adamantyl)-1-[(4-carbamimidamidophenyl)methyl...)
Affinity DataKi: >1.00E+6nM ΔG°: >-17.1kJ/molepH: 8.0 T: 2°CAssay Description:The measurements were carried out on a microplate reader. Two concentrations of the substrate and five concentrations of the inhibitor were used in t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Max-Planck-Institut Fuer Biochemie

LigandPNGBDBM16173(3,5-diamino-6-chloro-N-(diaminomethylene)pyrazinam...)
Affinity DataKi: >1.00E+6nM ΔG°: >-17.1kJ/molepH: 8.0 T: 2°CAssay Description:The measurements were carried out on a microplate reader. Two concentrations of the substrate and five concentrations of the inhibitor were used in t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed