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Compile Data Set for Download or QSAR

Found 243 hits Enz. Inhib. hit(s) with all data for assayid = 2 entry = 2062   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM344324
PNG
(US10251889, Example 33 | US9782415, Example 33 | U...)
Show SMILES OC(=O)[C@H]1CC[C@@H](CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C24H25F2N5O3/c25-15-5-8-19(26)17(12-15)20-2-1-10-30(20)21-9-11-31-22(29-21)18(13-27-31)23(32)28-16-6-3-14(4-7-16)24(33)34/h5,8-9,11-14,16,20H,1-4,6-7,10H2,(H,28,32)(H,33,34)/t14-,16-,20-/s2
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n/an/a 23.4n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US9796724 (2017)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM344325
PNG
(US10251889, Example 34 | US9782415, Example 34 | U...)
Show SMILES OCc1ccc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)N[C@H]3CC[C@H](O)CC3)c2n1
Show InChI InChI=1/C24H28FN5O3/c25-16-4-3-15(14-31)19(12-16)21-2-1-10-29(21)22-9-11-30-23(28-22)20(13-26-30)24(33)27-17-5-7-18(32)8-6-17/h3-4,9,11-13,17-18,21,31-32H,1-2,5-8,10,14H2,(H,27,33)/t17-,18-,21-/s2
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n/an/a 42.3n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US9796724 (2017)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM127767
PNG
(US10251889, Example 140 | US8791123, 140 | US97824...)
Show SMILES COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NC3CC[C@H](O)CC3)c2n1
Show InChI InChI=1/C23H27FN6O3/c1-33-23-17(11-14(24)12-25-23)19-3-2-9-29(19)20-8-10-30-21(28-20)18(13-26-30)22(32)27-15-4-6-16(31)7-5-15/h8,10-13,15-16,19,31H,2-7,9H2,1H3,(H,27,32)/t15?,16-,19-/s2
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n/an/a 76.7n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US9796724 (2017)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM127767
PNG
(US10251889, Example 140 | US8791123, 140 | US97824...)
Show SMILES COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NC3CC[C@H](O)CC3)c2n1
Show InChI InChI=1/C23H27FN6O3/c1-33-23-17(11-14(24)12-25-23)19-3-2-9-29(19)20-8-10-30-21(28-20)18(13-26-30)22(32)27-15-4-6-16(31)7-5-15/h8,10-13,15-16,19,31H,2-7,9H2,1H3,(H,27,32)/t15?,16-,19-/s2
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n/an/a 76.7n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US9796724 (2017)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM127634
PNG
(US10251889, Example 7 | US8791123, 7 | US9782415, ...)
Show SMILES O[C@H]1CC[C@@H](CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C23H25F2N5O2/c24-14-3-8-19(25)17(12-14)20-2-1-10-29(20)21-9-11-30-22(28-21)18(13-26-30)23(32)27-15-4-6-16(31)7-5-15/h3,8-9,11-13,15-16,20,31H,1-2,4-7,10H2,(H,27,32)/t15-,16-,20-/s2
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n/an/a 107n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US9796724 (2017)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM127642
PNG
(US10251889, Example 15 | US8791123, 15 | US9782415...)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)N[C@H]3CC4CCC3C4)c2n1
Show InChI InChI=1/C24H25F2N5O/c25-16-5-6-19(26)17(12-16)21-2-1-8-30(21)22-7-9-31-23(29-22)18(13-27-31)24(32)28-20-11-14-3-4-15(20)10-14/h5-7,9,12-15,20-21H,1-4,8,10-11H2,(H,28,32)/t14?,15?,20-,21+/s2
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n/an/a 156n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US9796724 (2017)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM127677
PNG
(US10251889, Example 51 | US8791123, 50 | US9782415...)
Show SMILES C[C@@]1(O)CCC(CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C24H27F2N5O2/c1-24(33)9-6-16(7-10-24)28-23(32)18-14-27-31-12-8-21(29-22(18)31)30-11-2-3-20(30)17-13-15(25)4-5-19(17)26/h4-5,8,12-14,16,20,33H,2-3,6-7,9-11H2,1H3,(H,28,32)/t16?,20-,24-/s2
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n/an/a 186n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US9796724 (2017)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM344336
PNG
(US10251889, Example 45 | US9782415, Example 45 | U...)
Show SMILES NS(=O)(=O)N1CCC(CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C22H25F2N7O3S/c23-14-3-4-18(24)16(12-14)19-2-1-8-30(19)20-7-11-31-21(28-20)17(13-26-31)22(32)27-15-5-9-29(10-6-15)35(25,33)34/h3-4,7,11-13,15,19H,1-2,5-6,8-10H2,(H,27,32)(H2,25,33,34)/t19-/s2
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n/an/a 195n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US9796724 (2017)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM127647
PNG
(US10251889, Example 20 | US8791123, 20 | US9782415...)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)NC3CCOCC3)c2n1
Show InChI InChI=1/C22H23F2N5O2/c23-14-3-4-18(24)16(12-14)19-2-1-8-28(19)20-5-9-29-21(27-20)17(13-25-29)22(30)26-15-6-10-31-11-7-15/h3-5,9,12-13,15,19H,1-2,6-8,10-11H2,(H,26,30)/t19-/s2
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n/an/a 257n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US9796724 (2017)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM127662
PNG
(US10251889, Example 35 | US8791123, 35 | US9782415...)
Show SMILES O[C@H]1CC[C@@H](CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cccc(F)c1
Show InChI InChI=1/C23H26FN5O2/c24-16-4-1-3-15(13-16)20-5-2-11-28(20)21-10-12-29-22(27-21)19(14-25-29)23(31)26-17-6-8-18(30)9-7-17/h1,3-4,10,12-14,17-18,20,30H,2,5-9,11H2,(H,26,31)/t17-,18-,20-/s2
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n/an/a 278n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US9796724 (2017)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM127862
PNG
(US10251889, Example 235 | US8791123, 235 | US97824...)
Show SMILES C[C@@H](NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)cn(C)c1=O)C1CC1
Show InChI InChI=1/C22H25FN6O2/c1-13(14-5-6-14)25-21(30)17-11-24-29-9-7-19(26-20(17)29)28-8-3-4-18(28)16-10-15(23)12-27(2)22(16)31/h7,9-14,18H,3-6,8H2,1-2H3,(H,25,30)/t13-,18-/s2
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n/an/a 311n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US9796724 (2017)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM344335
PNG
(US10251889, Example 44 | US9782415, Example 44 | U...)
Show SMILES CS(=O)(=O)N1CCC(CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C23H26F2N6O3S/c1-35(33,34)29-10-6-16(7-11-29)27-23(32)18-14-26-31-12-8-21(28-22(18)31)30-9-2-3-20(30)17-13-15(24)4-5-19(17)25/h4-5,8,12-14,16,20H,2-3,6-7,9-11H2,1H3,(H,27,32)/t20-/s2
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n/an/a 388n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US9796724 (2017)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM127677
PNG
(US10251889, Example 51 | US8791123, 50 | US9782415...)
Show SMILES C[C@@]1(O)CCC(CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C24H27F2N5O2/c1-24(33)9-6-16(7-10-24)28-23(32)18-14-27-31-12-8-21(29-22(18)31)30-11-2-3-20(30)17-13-15(25)4-5-19(17)26/h4-5,8,12-14,16,20,33H,2-3,6-7,9-11H2,1H3,(H,28,32)/t16?,20-,24-/s2
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n/an/a 418n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US9796724 (2017)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM127863
PNG
(US10251889, Example 236 | US8791123, 236 | US97824...)
Show SMILES C[C@H](NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)cn(C)c1=O)C1CC1
Show InChI InChI=1/C22H25FN6O2/c1-13(14-5-6-14)25-21(30)17-11-24-29-9-7-19(26-20(17)29)28-8-3-4-18(28)16-10-15(23)12-27(2)22(16)31/h7,9-14,18H,3-6,8H2,1-2H3,(H,25,30)/t13-,18+/s2
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n/an/a 419n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US9796724 (2017)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM344339
PNG
(US10251889, Example 48 | US9782415, Example 48 | U...)
Show SMILES OCc1ccc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NC3CC3)c2n1
Show InChI InChI=1/C21H22FN5O2/c22-14-4-3-13(12-28)16(10-14)18-2-1-8-26(18)19-7-9-27-20(25-19)17(11-23-27)21(29)24-15-5-6-15/h3-4,7,9-11,15,18,28H,1-2,5-6,8,12H2,(H,24,29)/t18-/s2
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n/an/a 429n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US9796724 (2017)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM127789
PNG
(US10251889, Example 162 | US8791123, 162 | US97824...)
Show SMILES COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NC3CCN(CC3)S(C)(=O)=O)c2n1
Show InChI InChI=1/C23H28FN7O4S/c1-35-23-17(12-15(24)13-25-23)19-4-3-8-30(19)20-7-11-31-21(28-20)18(14-26-31)22(32)27-16-5-9-29(10-6-16)36(2,33)34/h7,11-14,16,19H,3-6,8-10H2,1-2H3,(H,27,32)/t19-/s2
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n/an/a 444n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US9796724 (2017)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM127854
PNG
(US10251889, Example 227 | US8791123, 227 | US97824...)
Show SMILES CC(C)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)cn(C)c1=O
Show InChI InChI=1/C20H23FN6O2/c1-12(2)23-19(28)15-10-22-27-8-6-17(24-18(15)27)26-7-4-5-16(26)14-9-13(21)11-25(3)20(14)29/h6,8-12,16H,4-5,7H2,1-3H3,(H,23,28)/t16-/s2
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n/an/a 446n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US9796724 (2017)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM127641
PNG
(US10251889, Example 14 | US8791123, 14 | US9782415...)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)NC3CCC3)c2n1
Show InChI InChI=1/C21H21F2N5O/c22-13-6-7-17(23)15(11-13)18-5-2-9-27(18)19-8-10-28-20(26-19)16(12-24-28)21(29)25-14-3-1-4-14/h6-8,10-12,14,18H,1-5,9H2,(H,25,29)/t18-/s2
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n/an/a 470n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US9796724 (2017)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM127717
PNG
(US10251889, Example 90 | US8791123, 90 | US9782415...)
Show SMILES COCCOc1ccc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NC3CC3)c2n1
Show InChI InChI=1/C23H26FN5O3/c1-31-11-12-32-20-7-4-15(24)13-17(20)19-3-2-9-28(19)21-8-10-29-22(27-21)18(14-25-29)23(30)26-16-5-6-16/h4,7-8,10,13-14,16,19H,2-3,5-6,9,11-12H2,1H3,(H,26,30)/t19-/s2
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n/an/a 472n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US9796724 (2017)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM127865
PNG
(US10251889, Example 238 | US8791123, 238 | US97824...)
Show SMILES Cn1cc(F)cc([C@H]2CCCN2c2ccn3ncc(C(=O)NC4CC[C@H](O)CC4)c3n2)c1=O
Show InChI InChI=1/C23H27FN6O3/c1-28-13-14(24)11-17(23(28)33)19-3-2-9-29(19)20-8-10-30-21(27-20)18(12-25-30)22(32)26-15-4-6-16(31)7-5-15/h8,10-13,15-16,19,31H,2-7,9H2,1H3,(H,26,32)/t15?,16-,19-/s2
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n/an/a 499n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US9796724 (2017)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM127781
PNG
(US10251889, Example 154 | US8791123, 154 | US97824...)
Show SMILES COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)N[C@H]3CC[C@H](O)C3)c2n1
Show InChI InChI=1/C22H25FN6O3/c1-32-22-16(9-13(23)11-24-22)18-3-2-7-28(18)19-6-8-29-20(27-19)17(12-25-29)21(31)26-14-4-5-15(30)10-14/h6,8-9,11-12,14-15,18,30H,2-5,7,10H2,1H3,(H,26,31)/t14-,15-,18+/s2
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n/an/a 524n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US9796724 (2017)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM127844
PNG
(US10251889, Example 217 | US8791123, 217 | US97824...)
Show SMILES CC(C)NC(=O)c1cnn2ccc(nc12)N1C[C@@H](O)C[C@@H]1c1cccc(F)c1
Show InChI InChI=1/C20H22FN5O2/c1-12(2)23-20(28)16-10-22-26-7-6-18(24-19(16)26)25-11-15(27)9-17(25)13-4-3-5-14(21)8-13/h3-8,10,12,15,17,27H,9,11H2,1-2H3,(H,23,28)/t15-,17+/s2
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n/an/a 551n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US9796724 (2017)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM127691
PNG
(US10251889, Example 64 | US8791123, 64 | US9782415...)
Show SMILES NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1C(F)(F)F
Show InChI InChI=1/C18H15F4N5O/c19-10-3-4-13(18(20,21)22)11(8-10)14-2-1-6-26(14)15-5-7-27-17(25-15)12(9-24-27)16(23)28/h3-5,7-9,14H,1-2,6H2,(H2,23,28)/t14-/s2
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n/an/a 575n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US9796724 (2017)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM127864
PNG
(US10251889, Example 237 | US8791123, 237 | US97824...)
Show SMILES Cn1cc(F)cc([C@H]2CCCN2c2ccn3ncc(C(=O)NC4(C)CC4)c3n2)c1=O
Show InChI InChI=1/C21H23FN6O2/c1-21(6-7-21)25-19(29)15-11-23-28-9-5-17(24-18(15)28)27-8-3-4-16(27)14-10-13(22)12-26(2)20(14)30/h5,9-12,16H,3-4,6-8H2,1-2H3,(H,25,29)/t16-/s2
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n/an/a 616n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US9796724 (2017)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM344372
PNG
(US10251889, Example 81 | US9782415, Example 81 | U...)
Show SMILES CC(C)(CF)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)cnc1CO
Show InChI InChI=1/C21H24F2N6O2/c1-21(2,12-22)27-20(31)15-10-25-29-7-5-18(26-19(15)29)28-6-3-4-17(28)14-8-13(23)9-24-16(14)11-30/h5,7-10,17,30H,3-4,6,11-12H2,1-2H3,(H,27,31)/t17-/s2
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n/an/a 666n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US9796724 (2017)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM127857
PNG
(US10251889, Example 230 | US8791123, 230 | US97824...)
Show SMILES Cn1cc(F)cc([C@H]2CCCN2c2ccn3ncc(C(=O)NC4CCC4)c3n2)c1=O
Show InChI InChI=1/C21H23FN6O2/c1-26-12-13(22)10-15(21(26)30)17-6-3-8-27(17)18-7-9-28-19(25-18)16(11-23-28)20(29)24-14-4-2-5-14/h7,9-12,14,17H,2-6,8H2,1H3,(H,24,29)/t17-/s2
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n/an/a 666n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US9796724 (2017)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM344501
PNG
(US10251889, Example 216 | US9782415, Example 216 |...)
Show SMILES C[C@H](NC(=O)c1cnn2ccc(nc12)N1C[C@@H](O)C[C@@H]1c1cccc(F)c1)C(F)(F)F
Show InChI InChI=1/C20H19F4N5O2/c1-11(20(22,23)24)26-19(31)15-9-25-29-6-5-17(27-18(15)29)28-10-14(30)8-16(28)12-3-2-4-13(21)7-12/h2-7,9,11,14,16,30H,8,10H2,1H3,(H,26,31)/t11-,14-,16+/s2
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n/an/a 670n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US9796724 (2017)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM344370
PNG
(US10251889, Example 79 | US9782415, Example 79 | U...)
Show SMILES OCc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)NC3CC3)c2n1
Show InChI InChI=1/C20H21FN6O2/c21-12-8-14(16(11-28)22-9-12)17-2-1-6-26(17)18-5-7-27-19(25-18)15(10-23-27)20(29)24-13-3-4-13/h5,7-10,13,17,28H,1-4,6,11H2,(H,24,29)/t17-/s2
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n/an/a 698n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US9796724 (2017)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM127688
PNG
(US10251889, Example 61 | US8791123, 61 | US9782415...)
Show SMILES F[C@H]1CNCC[C@H]1NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C22H23F3N6O/c23-13-3-4-16(24)14(10-13)19-2-1-8-30(19)20-6-9-31-21(29-20)15(11-27-31)22(32)28-18-5-7-26-12-17(18)25/h3-4,6,9-11,17-19,26H,1-2,5,7-8,12H2,(H,28,32)/t17-,18+,19+/s2
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n/an/a 699n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US9796724 (2017)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM127751
PNG
(US10251889, Example 124 | US8791123, 124 | US97824...)
Show SMILES C[C@H](NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cncc(F)c1)C1CC1
Show InChI InChI=1/C21H23FN6O/c1-13(14-4-5-14)25-21(29)17-12-24-28-8-6-19(26-20(17)28)27-7-2-3-18(27)15-9-16(22)11-23-10-15/h6,8-14,18H,2-5,7H2,1H3,(H,25,29)/t13-,18+/s2
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n/an/a 759n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US9796724 (2017)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM127751
PNG
(US10251889, Example 124 | US8791123, 124 | US97824...)
Show SMILES C[C@H](NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cncc(F)c1)C1CC1
Show InChI InChI=1/C21H23FN6O/c1-13(14-4-5-14)25-21(29)17-12-24-28-8-6-19(26-20(17)28)27-7-2-3-18(27)15-9-16(22)11-23-10-15/h6,8-14,18H,2-5,7H2,1H3,(H,25,29)/t13-,18+/s2
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n/an/a 759n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US9796724 (2017)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM127796
PNG
(US10251889, Example 169 | US8791123, 169 | US97824...)
Show SMILES O[C@H]1CC[C@@H](C1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C22H23F2N5O2/c23-13-3-6-18(24)16(10-13)19-2-1-8-28(19)20-7-9-29-21(27-20)17(12-25-29)22(31)26-14-4-5-15(30)11-14/h3,6-7,9-10,12,14-15,19,30H,1-2,4-5,8,11H2,(H,26,31)/t14-,15-,19+/s2
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n/an/a 759n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US9796724 (2017)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM344371
PNG
(US10251889, Example 80 | US9782415, Example 80 | U...)
Show SMILES CC(C)(C)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)cnc1CO
Show InChI InChI=1/C21H25FN6O2/c1-21(2,3)26-20(30)15-11-24-28-8-6-18(25-19(15)28)27-7-4-5-17(27)14-9-13(22)10-23-16(14)12-29/h6,8-11,17,29H,4-5,7,12H2,1-3H3,(H,26,30)/t17-/s2
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n/an/a 869n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US9796724 (2017)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM127628
PNG
(US10251889, Example 1 | US8791123, 1 | US9782415, ...)
Show SMILES CC(C)(C)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C21H23F2N5O/c1-21(2,3)26-20(29)15-12-24-28-10-8-18(25-19(15)28)27-9-4-5-17(27)14-11-13(22)6-7-16(14)23/h6-8,10-12,17H,4-5,9H2,1-3H3,(H,26,29)/t17-/s2
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US9796724 (2017)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM127629
PNG
(US10251889, Example 2 | US8791123, 2 | US9782415, ...)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)Nc3ccccn3)c2n1
Show InChI InChI=1/C22H18F2N6O/c23-14-6-7-17(24)15(12-14)18-4-3-10-29(18)20-8-11-30-21(28-20)16(13-26-30)22(31)27-19-5-1-2-9-25-19/h1-2,5-9,11-13,18H,3-4,10H2,(H,25,27,31)/t18-/s2
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US9796724 (2017)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM127630
PNG
(US10251889, Example 3 | US8791123, 3 | US9782415, ...)
Show SMILES Cc1cccnc1NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C23H20F2N6O/c1-14-4-2-9-26-21(14)29-23(32)17-13-27-31-11-8-20(28-22(17)31)30-10-3-5-19(30)16-12-15(24)6-7-18(16)25/h2,4,6-9,11-13,19H,3,5,10H2,1H3,(H,26,29,32)/t19-/s2
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US9796724 (2017)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM127631
PNG
(US10251889, Example 4 | US8791123, 4 | US9782415, ...)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)NCCN3CCOCC3)c2n1
Show InChI InChI=1/C23H26F2N6O2/c24-16-3-4-19(25)17(14-16)20-2-1-7-30(20)21-5-8-31-22(28-21)18(15-27-31)23(32)26-6-9-29-10-12-33-13-11-29/h3-5,8,14-15,20H,1-2,6-7,9-13H2,(H,26,32)/t20-/s2
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US9796724 (2017)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM127632
PNG
(US10251889, Example 5 | US8791123, 5 | US9782415, ...)
Show SMILES Cc1ccc(CNC(=O)c2cnn3ccc(nc23)N2CCC[C@@H]2c2cc(F)ccc2F)o1
Show InChI InChI=1/C23H21F2N5O2/c1-14-4-6-16(32-14)12-26-23(31)18-13-27-30-10-8-21(28-22(18)30)29-9-2-3-20(29)17-11-15(24)5-7-19(17)25/h4-8,10-11,13,20H,2-3,9,12H2,1H3,(H,26,31)/t20-/s2
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US9796724 (2017)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM127633
PNG
(US10251889, Example 6 | US8791123, 6 | US9782415, ...)
Show SMILES Cn1ccc(NC(=O)c2cnn3ccc(nc23)N2CCC[C@@H]2c2cc(F)ccc2F)n1
Show InChI InChI=1/C21H19F2N7O/c1-28-9-6-18(27-28)25-21(31)15-12-24-30-10-7-19(26-20(15)30)29-8-2-3-17(29)14-11-13(22)4-5-16(14)23/h4-7,9-12,17H,2-3,8H2,1H3,(H,25,27,31)/t17-/s2
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US9796724 (2017)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM127635
PNG
(US10251889, Example 8 | US8791123, 8 | US9782415, ...)
Show SMILES CC(C)(CO)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C21H23F2N5O2/c1-21(2,12-29)26-20(30)15-11-24-28-9-7-18(25-19(15)28)27-8-3-4-17(27)14-10-13(22)5-6-16(14)23/h5-7,9-11,17,29H,3-4,8,12H2,1-2H3,(H,26,30)/t17-/s2
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US9796724 (2017)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM127636
PNG
(US10251889, Example 9 | US8791123, 9 | US9782415, ...)
Show SMILES CC(C)(CN1CCOCC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C25H30F2N6O2/c1-25(2,16-31-10-12-35-13-11-31)30-24(34)19-15-28-33-9-7-22(29-23(19)33)32-8-3-4-21(32)18-14-17(26)5-6-20(18)27/h5-7,9,14-15,21H,3-4,8,10-13,16H2,1-2H3,(H,30,34)/t21-/s2
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US9796724 (2017)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM127637
PNG
(US10251889, Example 10 | US8791123, 10 | US9782415...)
Show SMILES CNC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C18H17F2N5O/c1-21-18(26)13-10-22-25-8-6-16(23-17(13)25)24-7-2-3-15(24)12-9-11(19)4-5-14(12)20/h4-6,8-10,15H,2-3,7H2,1H3,(H,21,26)/t15-/s2
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US9796724 (2017)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM344302
PNG
(US10251889, Example 11 | US9782415, Example 11 | U...)
Show SMILES OC(=O)C1CCN(CC1)C(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C23H23F2N5O3/c24-15-3-4-18(25)16(12-15)19-2-1-8-29(19)20-7-11-30-21(27-20)17(13-26-30)22(31)28-9-5-14(6-10-28)23(32)33/h3-4,7,11-14,19H,1-2,5-6,8-10H2,(H,32,33)/t19-/s2
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US9796724 (2017)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM344303
PNG
(US10251889, Example 12 | US9782415, Example 12 | U...)
Show SMILES OC(=O)CC1CCN(CC1)C(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C24H25F2N5O3/c25-16-3-4-19(26)17(13-16)20-2-1-8-30(20)21-7-11-31-23(28-21)18(14-27-31)24(34)29-9-5-15(6-10-29)12-22(32)33/h3-4,7,11,13-15,20H,1-2,5-6,8-10,12H2,(H,32,33)/t20-/s2
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US9796724 (2017)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM127640
PNG
(US10251889, Example 13 | US8791123, 13 | US9782415...)
Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)NC3CC3)c2n1
Show InChI InChI=1/C20H19F2N5O/c21-12-3-6-16(22)14(10-12)17-2-1-8-26(17)18-7-9-27-19(25-18)15(11-23-27)20(28)24-13-4-5-13/h3,6-7,9-11,13,17H,1-2,4-5,8H2,(H,24,28)/t17-/s2
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US9796724 (2017)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM127643
PNG
(US10251889, Example 16 | US8791123, 16 | US9782415...)
Show SMILES OCC1(CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C21H21F2N5O2/c22-13-3-4-16(23)14(10-13)17-2-1-8-27(17)18-5-9-28-19(25-18)15(11-24-28)20(30)26-21(12-29)6-7-21/h3-5,9-11,17,29H,1-2,6-8,12H2,(H,26,30)/t17-/s2
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US9796724 (2017)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM127644
PNG
(US10251889, Example 17 | US8791123, 17 | US9782415...)
Show SMILES CC(C)(O)CNC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C21H23F2N5O2/c1-21(2,30)12-24-20(29)15-11-25-28-9-7-18(26-19(15)28)27-8-3-4-17(27)14-10-13(22)5-6-16(14)23/h5-7,9-11,17,30H,3-4,8,12H2,1-2H3,(H,24,29)/t17-/s2
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US9796724 (2017)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM127645
PNG
(US10251889, Example 18 | US8791123, 18 | US9782415...)
Show SMILES O[C@H]1CCN(C1)C(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C21H21F2N5O2/c22-13-3-4-17(23)15(10-13)18-2-1-7-27(18)19-6-9-28-20(25-19)16(11-24-28)21(30)26-8-5-14(29)12-26/h3-4,6,9-11,14,18,29H,1-2,5,7-8,12H2/t14-,18+/s2
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US9796724 (2017)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM127646
PNG
(US10251889, Example 19 | US8791123, 19 | US9782415...)
Show SMILES O[C@@H]1CCN(C1)C(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F
Show InChI InChI=1/C21H21F2N5O2/c22-13-3-4-17(23)15(10-13)18-2-1-7-27(18)19-6-9-28-20(25-19)16(11-24-28)21(30)26-8-5-14(29)12-26/h3-4,6,9-11,14,18,29H,1-2,5,7-8,12H2/t14-,18-/s2
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US9796724 (2017)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
JAK2 (aa 808-1132)


(Homo sapiens (Human))
BDBM127648
PNG
(US10251889, Example 21 | US8791123, 21 | US9782415...)
Show SMILES Cn1cnc(CNC(=O)c2cnn3ccc(nc23)N2CCC[C@@H]2c2cc(F)ccc2F)c1
Show InChI InChI=1/C22H21F2N7O/c1-29-12-15(26-13-29)10-25-22(32)17-11-27-31-8-6-20(28-21(17)31)30-7-2-3-19(30)16-9-14(23)4-5-18(16)24/h4-6,8-9,11-13,19H,2-3,7,10H2,1H3,(H,25,32)/t19-/s2
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n/an/a>1.00E+3n/an/an/an/an/an/a



Array BioPharma, Inc.

US Patent


Assay Description
Compounds of Formula I were screened for their ability to inhibit Jak2 using the general enzyme inhibition assay method, in which the assay mixture c...


US Patent US9796724 (2017)


Article DOI: 10.1021/jm0701019
BindingDB Entry DOI: 10.7270/Q27M0B21
More data for this
Ligand-Target Pair
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