BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 72 hits Enz. Inhib. hit(s) with all data for assayid = 3 entry = 1647   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM334340
PNG
(1-(2,3-Dichloro-4-((2-((3-(cyclopropylsulfonyl)phe...)
Show SMILES CC(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4cccc(c4)S(=O)(=O)C4CC4)n3)c(Cl)c2Cl)n(n1)-c1ccc(C)cc1
Show InChI InChI=1S/C33H31Cl2N7O4S/c1-19(2)26-18-28(42(41-26)22-9-7-20(3)8-10-22)39-33(43)38-25-13-14-27(31(35)30(25)34)46-29-15-16-36-32(40-29)37-21-5-4-6-24(17-21)47(44,45)23-11-12-23/h4-10,13-19,23H,11-12H2,1-3H3,(H,36,37,40)(H2,38,39,43)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 117n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM334323
PNG
(1-(3-(tert-Butyl)-1-(6-methoxypyridin-3-yl)-1H-pyr...)
Show SMILES COc1ccc(cn1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cccc(c3)S(=O)C3CC3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C37H36N8O4S/c1-37(2,3)31-21-32(45(44-31)24-12-17-33(48-4)39-22-24)42-36(46)41-29-15-16-30(28-11-6-5-10-27(28)29)49-34-18-19-38-35(43-34)40-23-8-7-9-26(20-23)50(47)25-13-14-25/h5-12,15-22,25H,13-14H2,1-4H3,(H,38,40,43)(H2,41,42,46)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 125n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM334362
PNG
(1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cccc(c3)S(=O)(=O)C3CC3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C38H37N7O4S/c1-24-12-14-26(15-13-24)45-34(23-33(44-45)38(2,3)4)42-37(46)41-31-18-19-32(30-11-6-5-10-29(30)31)49-35-20-21-39-36(43-35)40-25-8-7-9-28(22-25)50(47,48)27-16-17-27/h5-15,18-23,27H,16-17H2,1-4H3,(H,39,40,43)(H2,41,42,46)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 172n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM334324
PNG
(1-(3-(tert-Butyl)-1-(6-methoxypyridin-3-yl)-1H-pyr...)
Show SMILES COc1ccc(cn1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cccc(c3)S(=O)(=O)C3CC3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C37H36N8O5S/c1-37(2,3)31-21-32(45(44-31)24-12-17-33(49-4)39-22-24)42-36(46)41-29-15-16-30(28-11-6-5-10-27(28)29)50-34-18-19-38-35(43-34)40-23-8-7-9-26(20-23)51(47,48)25-13-14-25/h5-12,15-22,25H,13-14H2,1-4H3,(H,38,40,43)(H2,41,42,46)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 258n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM334321
PNG
(3-(4-((4-(3-(3-(tert-Butyl)-1-(6-methoxypyridin-3-...)
Show SMILES COc1ccc(cn1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cccc(OC(N)=O)c3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H33N9O5/c1-35(2,3)28-19-29(44(43-28)22-12-15-30(47-4)38-20-22)41-34(46)40-26-13-14-27(25-11-6-5-10-24(25)26)49-31-16-17-37-33(42-31)39-21-8-7-9-23(18-21)48-32(36)45/h5-20H,1-4H3,(H2,36,45)(H,37,39,42)(H2,40,41,46)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 306n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM334330
PNG
(3-(4-((4-(3-(3-Isopropyl-1-(p-tolyl)-1H-pyrazol-5-...)
Show SMILES CC(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4cccc(c4)N=S(C)(C)=O)n3)c3ccccc23)n(n1)-c1ccc(C)cc1
Show InChI InChI=1S/C36H36N8O3S/c1-23(2)31-22-33(44(42-31)27-15-13-24(3)14-16-27)40-36(45)39-30-17-18-32(29-12-7-6-11-28(29)30)47-34-19-20-37-35(41-34)38-25-9-8-10-26(21-25)43-48(4,5)46/h6-23H,1-5H3,(H,37,38,41)(H2,39,40,45)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 416n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM334342
PNG
(S,S-Dimethyl-N-(3-(4-(2,3-dichloro-4-(3-(3-isoprop...)
Show SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)C)c(Cl)c3Cl)n2)cc(c1)N=S(C)(C)=O
Show InChI InChI=1S/C33H34Cl2N8O4S/c1-19(2)26-18-28(43(41-26)23-9-7-20(3)8-10-23)39-33(44)38-25-11-12-27(31(35)30(25)34)47-29-13-14-36-32(40-29)37-21-15-22(42-48(5,6)45)17-24(16-21)46-4/h7-19H,1-6H3,(H,36,37,40)(H2,38,39,44)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 426n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM334322
PNG
(1-(3-(tert-Butyl)-1-(6-methoxypyridin-3-yl)-1H-pyr...)
Show SMILES COc1ccc(cn1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cccc(SCCO)c3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C36H36N8O4S/c1-36(2,3)30-21-31(44(43-30)24-12-15-32(47-4)38-22-24)41-35(46)40-28-13-14-29(27-11-6-5-10-26(27)28)48-33-16-17-37-34(42-33)39-23-8-7-9-25(20-23)49-19-18-45/h5-17,20-22,45H,18-19H2,1-4H3,(H,37,39,42)(H2,40,41,46)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 501n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM334359
PNG
(1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(...)
Show SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc(c1)S(=O)(=O)CCCN1CCOCC1
Show InChI InChI=1S/C43H48N8O6S/c1-29-11-13-31(14-12-29)51-39(28-38(49-51)43(2,3)4)47-42(52)46-36-15-16-37(35-10-7-6-9-34(35)36)57-40-17-18-44-41(48-40)45-30-25-32(55-5)27-33(26-30)58(53,54)24-8-19-50-20-22-56-23-21-50/h6-7,9-18,25-28H,8,19-24H2,1-5H3,(H,44,45,48)(H2,46,47,52)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 531n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM334352
PNG
(1-(3-Isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-(...)
Show SMILES COCCOCCOCCS(=O)(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)C)c4ccccc34)n2)cc(OC)c1
Show InChI InChI=1S/C42H47N7O8S/c1-28(2)37-27-39(49(48-37)31-12-10-29(3)11-13-31)46-42(50)45-36-14-15-38(35-9-7-6-8-34(35)36)57-40-16-17-43-41(47-40)44-30-24-32(54-5)26-33(25-30)58(51,52)23-22-56-21-20-55-19-18-53-4/h6-17,24-28H,18-23H2,1-5H3,(H,43,44,47)(H2,45,46,50)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 596n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM334341
PNG
(1-(2,3-Difluoro-4-((2-((3-methoxy-5-(2-morpholinoe...)
Show SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)C)c(F)c3F)n2)cc(OCCN2CCOCC2)c1
Show InChI InChI=1S/C37H40F2N8O5/c1-23(2)30-22-32(47(45-30)26-7-5-24(3)6-8-26)43-37(48)42-29-9-10-31(35(39)34(29)38)52-33-11-12-40-36(44-33)41-25-19-27(49-4)21-28(20-25)51-18-15-46-13-16-50-17-14-46/h5-12,19-23H,13-18H2,1-4H3,(H,40,41,44)(H2,42,43,48)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 804n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM334332
PNG
(3-(5-Methoxy((4-((4-(3-(3-isopropyl-1-(p-tolyl)-1H...)
Show SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)C)c4ccccc34)n2)cc(c1)N=S(C)(C)=O
Show InChI InChI=1S/C37H38N8O4S/c1-23(2)32-22-34(45(43-32)27-13-11-24(3)12-14-27)41-37(46)40-31-15-16-33(30-10-8-7-9-29(30)31)49-35-17-18-38-36(42-35)39-25-19-26(44-50(5,6)47)21-28(20-25)48-4/h7-23H,1-6H3,(H,38,39,42)(H2,40,41,46)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 824n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM334320
PNG
(1-(3-(tert-Butyl)-1-(6-methoxypyridin-3-yl)-1H-pyr...)
Show SMILES COCCOCCOCCOc1cccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(OC)nc4)C(C)(C)C)c4ccccc34)n2)c1
Show InChI InChI=1S/C41H46N8O7/c1-41(2,3)35-26-36(49(48-35)29-13-16-37(52-5)43-27-29)46-40(50)45-33-14-15-34(32-12-7-6-11-31(32)33)56-38-17-18-42-39(47-38)44-28-9-8-10-30(25-28)55-24-23-54-22-21-53-20-19-51-4/h6-18,25-27H,19-24H2,1-5H3,(H,42,44,47)(H2,45,46,50)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 973n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM334378
PNG
(1-(3-(tert-Butyl)-1-(P-tolyl)-1H-pyrazol-5-yl)-3-(...)
Show SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc(OCCOCCOCCO)c1
Show InChI InChI=1S/C42H47N7O7/c1-28-10-12-30(13-11-28)49-38(27-37(48-49)42(2,3)4)46-41(51)45-35-14-15-36(34-9-7-6-8-33(34)35)56-39-16-17-43-40(47-39)44-29-24-31(52-5)26-32(25-29)55-23-22-54-21-20-53-19-18-50/h6-17,24-27,50H,18-23H2,1-5H3,(H,43,44,47)(H2,45,46,51)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.03E+3n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM334335
PNG
(1-(4-((2-((3-(2-(2-(2-Hydroxyethoxy)ethoxy)ethoxy)...)
Show SMILES CC(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4cccc(OCCOCCOCCO)c4)n3)c3ccccc23)n(n1)-c1ccc(C)cc1
Show InChI InChI=1S/C40H43N7O6/c1-27(2)35-26-37(47(46-35)30-13-11-28(3)12-14-30)44-40(49)43-34-15-16-36(33-10-5-4-9-32(33)34)53-38-17-18-41-39(45-38)42-29-7-6-8-31(25-29)52-24-23-51-22-21-50-20-19-48/h4-18,25-27,48H,19-24H2,1-3H3,(H,41,42,45)(H2,43,44,49)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.07E+3n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM334371
PNG
(1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(...)
Show SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc(SCCO)c1
Show InChI InChI=1S/C38H39N7O4S/c1-24-10-12-26(13-11-24)45-34(23-33(44-45)38(2,3)4)42-37(47)41-31-14-15-32(30-9-7-6-8-29(30)31)49-35-16-17-39-36(43-35)40-25-20-27(48-5)22-28(21-25)50-19-18-46/h6-17,20-23,46H,18-19H2,1-5H3,(H,39,40,43)(H2,41,42,47)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.23E+3n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM334367
PNG
(1-(4-((2-((3-(2,5,8,11,14,17,20-Heptaoxadocosan-22...)
Show SMILES COCCOCCOCCOCCOCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc(OC)c1
Show InChI InChI=1S/C51H65N7O11/c1-37-11-13-39(14-12-37)58-47(36-46(57-58)51(2,3)4)55-50(59)54-44-15-16-45(43-10-8-7-9-42(43)44)69-48-17-18-52-49(56-48)53-38-33-40(61-6)35-41(34-38)68-32-31-67-30-29-66-28-27-65-26-25-64-24-23-63-22-21-62-20-19-60-5/h7-18,33-36H,19-32H2,1-6H3,(H,52,53,56)(H2,54,55,59)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.33E+3n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM334339
PNG
(1-(2,3-Dichloro-4-((2-((3-(cyclopropylsulfonyl)-5-...)
Show SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)C)c(Cl)c3Cl)n2)cc(c1)S(=O)(=O)C1CC1
Show InChI InChI=1S/C34H33Cl2N7O5S/c1-19(2)27-18-29(43(42-27)22-7-5-20(3)6-8-22)40-34(44)39-26-11-12-28(32(36)31(26)35)48-30-13-14-37-33(41-30)38-21-15-23(47-4)17-25(16-21)49(45,46)24-9-10-24/h5-8,11-19,24H,9-10H2,1-4H3,(H,37,38,41)(H2,39,40,44)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.40E+3n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM334361
PNG
(1-(3-(tert-Butyl)-1-(P-tolyl)-1H-pyrazol-5-yl)-3-(...)
Show SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc(OCCN2CCOCC2)c1
Show InChI InChI=1S/C42H46N8O5/c1-28-10-12-30(13-11-28)50-38(27-37(48-50)42(2,3)4)46-41(51)45-35-14-15-36(34-9-7-6-8-33(34)35)55-39-16-17-43-40(47-39)44-29-24-31(52-5)26-32(25-29)54-23-20-49-18-21-53-22-19-49/h6-17,24-27H,18-23H2,1-5H3,(H,43,44,47)(H2,45,46,51)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.49E+3n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM334318
PNG
(S,S-Dimethyl-N-(4-((4-((4-(3-(3-(tert-butyl)-1-(6-...)
Show SMILES COc1ccc(cn1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cccc(c3)N=S(C)(C)=O)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C36H37N9O4S/c1-36(2,3)30-21-31(45(43-30)25-14-17-32(48-4)38-22-25)41-35(46)40-28-15-16-29(27-13-8-7-12-26(27)28)49-33-18-19-37-34(42-33)39-23-10-9-11-24(20-23)44-50(5,6)47/h7-22H,1-6H3,(H,37,39,42)(H2,40,41,46)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.85E+3n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM334358
PNG
(1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(...)
Show SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc(SCCCN2CCOCC2)c1
Show InChI InChI=1S/C43H48N8O4S/c1-29-11-13-31(14-12-29)51-39(28-38(49-51)43(2,3)4)47-42(52)46-36-15-16-37(35-10-7-6-9-34(35)36)55-40-17-18-44-41(48-40)45-30-25-32(53-5)27-33(26-30)56-24-8-19-50-20-22-54-23-21-50/h6-7,9-18,25-28H,8,19-24H2,1-5H3,(H,44,45,48)(H2,46,47,52)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.93E+3n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM334373
PNG
(1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(...)
Show SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc(OCCOCCOCCN(C)C)c1
Show InChI InChI=1S/C44H52N8O6/c1-30-12-14-32(15-13-30)52-40(29-39(50-52)44(2,3)4)48-43(53)47-37-16-17-38(36-11-9-8-10-35(36)37)58-41-18-19-45-42(49-41)46-31-26-33(54-7)28-34(27-31)57-25-24-56-23-22-55-21-20-51(5)6/h8-19,26-29H,20-25H2,1-7H3,(H,45,46,49)(H2,47,48,53)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.94E+3n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM334364
PNG
(1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(...)
Show SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc(SCCCO)c1
Show InChI InChI=1S/C39H41N7O4S/c1-25-11-13-27(14-12-25)46-35(24-34(45-46)39(2,3)4)43-38(48)42-32-15-16-33(31-10-7-6-9-30(31)32)50-36-17-18-40-37(44-36)41-26-21-28(49-5)23-29(22-26)51-20-8-19-47/h6-7,9-18,21-24,47H,8,19-20H2,1-5H3,(H,40,41,44)(H2,42,43,48)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.05E+3n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM334319
PNG
(3-(4-((4-(3-(3-(tert-Butyl)-1-(6-methoxypyridin-3-...)
Show SMILES COc1ccc(cn1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cccc(OS(C)(=O)=O)c3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C35H34N8O6S/c1-35(2,3)29-20-30(43(42-29)23-13-16-31(47-4)37-21-23)40-34(44)39-27-14-15-28(26-12-7-6-11-25(26)27)48-32-17-18-36-33(41-32)38-22-9-8-10-24(19-22)49-50(5,45)46/h6-21H,1-5H3,(H,36,38,41)(H2,39,40,44)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.54E+3n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM334333
PNG
(1-(3-Isopropyl-1-(P-tolyl)-1H-pyrazol-5-yl)-3-(4-(...)
Show SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)C)c4ccccc34)n2)cc(OCCN2CCOCC2)c1
Show InChI InChI=1S/C41H44N8O5/c1-27(2)36-26-38(49(47-36)30-11-9-28(3)10-12-30)45-41(50)44-35-13-14-37(34-8-6-5-7-33(34)35)54-39-15-16-42-40(46-39)43-29-23-31(51-4)25-32(24-29)53-22-19-48-17-20-52-21-18-48/h5-16,23-27H,17-22H2,1-4H3,(H,42,43,46)(H2,44,45,50)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.67E+3n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM334374
PNG
(1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(...)
Show SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc(OCCOCCOCCN2CCOCC2)c1
Show InChI InChI=1S/C46H54N8O7/c1-32-10-12-34(13-11-32)54-42(31-41(52-54)46(2,3)4)50-45(55)49-39-14-15-40(38-9-7-6-8-37(38)39)61-43-16-17-47-44(51-43)48-33-28-35(56-5)30-36(29-33)60-27-26-59-25-24-58-23-20-53-18-21-57-22-19-53/h6-17,28-31H,18-27H2,1-5H3,(H,47,48,51)(H2,49,50,55)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.81E+3n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM334357
PNG
(1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(...)
Show SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc(SCCN2CCOCC2)c1
Show InChI InChI=1S/C42H46N8O4S/c1-28-10-12-30(13-11-28)50-38(27-37(48-50)42(2,3)4)46-41(51)45-35-14-15-36(34-9-7-6-8-33(34)35)54-39-16-17-43-40(47-39)44-29-24-31(52-5)26-32(25-29)55-23-20-49-18-21-53-22-19-49/h6-17,24-27H,18-23H2,1-5H3,(H,43,44,47)(H2,45,46,51)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.82E+3n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM334334
PNG
(1-(4-((2-((3-(Cyclopropylsulfonyl)-5-methoxyphenyl...)
Show SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)C)c4ccccc34)n2)cc(c1)S(=O)(=O)C1CC1
Show InChI InChI=1S/C38H37N7O5S/c1-23(2)33-22-35(45(44-33)26-11-9-24(3)10-12-26)42-38(46)41-32-15-16-34(31-8-6-5-7-30(31)32)50-36-17-18-39-37(43-36)40-25-19-27(49-4)21-29(20-25)51(47,48)28-13-14-28/h5-12,15-23,28H,13-14H2,1-4H3,(H,39,40,43)(H2,41,42,46)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 2.90E+3n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM334366
PNG
(1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(...)
Show SMILES COCCOCCOCCOc1cc(F)cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)c1
Show InChI InChI=1S/C42H46FN7O6/c1-28-10-12-31(13-11-28)50-38(27-37(49-50)42(2,3)4)47-41(51)46-35-14-15-36(34-9-7-6-8-33(34)35)56-39-16-17-44-40(48-39)45-30-24-29(43)25-32(26-30)55-23-22-54-21-20-53-19-18-52-5/h6-17,24-27H,18-23H2,1-5H3,(H,44,45,48)(H2,46,47,51)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.03E+3n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM334386
PNG
(1-(3-(tert-Butyl)-1-(4-methoxyphenyl)-1H-pyrazol-5...)
Show SMILES COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc(Nc3cc(OC)cc(c3)S(=O)(=O)C3CC3)n2)c2ccccc12)C(C)(C)C
Show InChI InChI=1S/C39H39N7O6S/c1-39(2,3)34-23-35(46(45-34)25-10-12-26(50-4)13-11-25)43-38(47)42-32-16-17-33(31-9-7-6-8-30(31)32)52-36-18-19-40-37(44-36)41-24-20-27(51-5)22-29(21-24)53(48,49)28-14-15-28/h6-13,16-23,28H,14-15H2,1-5H3,(H,40,41,44)(H2,42,43,47)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.35E+3n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM334382
PNG
(1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(...)
Show SMILES COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc(c1)N(C)C
Show InChI InChI=1S/C44H52N8O6/c1-30-12-14-32(15-13-30)52-40(29-39(50-52)44(2,3)4)48-43(53)47-37-16-17-38(36-11-9-8-10-35(36)37)58-41-18-19-45-42(49-41)46-31-26-33(51(5)6)28-34(27-31)57-25-24-56-23-22-55-21-20-54-7/h8-19,26-29H,20-25H2,1-7H3,(H,45,46,49)(H2,47,48,53)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.39E+3n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM334325
PNG
(1-(3-Isopropyl-1-(P-tolyl)-1H-pyrazol-5-yl)-3-(4-(...)
Show SMILES COCCOCCOCCOc1cccc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)C)c4ccccc34)n2)c1
Show InChI InChI=1S/C41H45N7O6/c1-28(2)36-27-38(48(47-36)31-14-12-29(3)13-15-31)45-41(49)44-35-16-17-37(34-11-6-5-10-33(34)35)54-39-18-19-42-40(46-39)43-30-8-7-9-32(26-30)53-25-24-52-23-22-51-21-20-50-4/h5-19,26-28H,20-25H2,1-4H3,(H,42,43,46)(H2,44,45,49)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.72E+3n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM334377
PNG
(1-(3-(tert-Butyl)-1-(6-methoxypyridin-3-yl)-1H-pyr...)
Show SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(OC)nc4)C(C)(C)C)c4ccccc34)n2)cc(c1)S(=O)(=O)C1CC1
Show InChI InChI=1S/C38H38N8O6S/c1-38(2,3)32-21-33(46(45-32)24-10-15-34(51-5)40-22-24)43-37(47)42-30-13-14-31(29-9-7-6-8-28(29)30)52-35-16-17-39-36(44-35)41-23-18-25(50-4)20-27(19-23)53(48,49)26-11-12-26/h6-10,13-22,26H,11-12H2,1-5H3,(H,39,41,44)(H2,42,43,47)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.80E+3n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM334336
PNG
(1-(4-((2-((3-(2-(2-(2-Hydroxyethoxy)ethoxy)ethoxy)...)
Show SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)C)c4ccccc34)n2)cc(OCCOCCOCCO)c1
Show InChI InChI=1S/C41H45N7O7/c1-27(2)36-26-38(48(47-36)30-11-9-28(3)10-12-30)45-41(50)44-35-13-14-37(34-8-6-5-7-33(34)35)55-39-15-16-42-40(46-39)43-29-23-31(51-4)25-32(24-29)54-22-21-53-20-19-52-18-17-49/h5-16,23-27,49H,17-22H2,1-4H3,(H,42,43,46)(H2,44,45,50)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 3.84E+3n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM334360
PNG
(1-(3-(tert-Butyl)-1-(4-methoxyphenyl)-1H-pyrazol-5...)
Show SMILES COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(OC)cc4)C(C)(C)C)c4ccccc34)n2)cc(OC)c1
Show InChI InChI=1S/C43H49N7O8/c1-43(2,3)38-28-39(50(49-38)30-11-13-31(53-5)14-12-30)47-42(51)46-36-15-16-37(35-10-8-7-9-34(35)36)58-40-17-18-44-41(48-40)45-29-25-32(54-6)27-33(26-29)57-24-23-56-22-21-55-20-19-52-4/h7-18,25-28H,19-24H2,1-6H3,(H,44,45,48)(H2,46,47,51)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.61E+3n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM334348
PNG
(1-(4-((2-((3-(2,5,8,11,14,17,20-Heptaoxadocosan-22...)
Show SMILES COCCOCCOCCOCCOCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)C)c4ccccc34)n2)cc(OC)c1
Show InChI InChI=1S/C50H63N7O11/c1-36(2)45-35-47(57(56-45)39-12-10-37(3)11-13-39)54-50(58)53-44-14-15-46(43-9-7-6-8-42(43)44)68-48-16-17-51-49(55-48)52-38-32-40(60-5)34-41(33-38)67-31-30-66-29-28-65-27-26-64-25-24-63-23-22-62-21-20-61-19-18-59-4/h6-17,32-36H,18-31H2,1-5H3,(H,51,52,55)(H2,53,54,58)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.69E+3n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM334379
PNG
(1-(3-(tert-Butyl)-1-(4-(dimethylamino)phenyl)-1H-p...)
Show SMILES COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(cc4)N(C)C)C(C)(C)C)c4ccccc34)n2)cc(OC)c1
Show InChI InChI=1S/C44H52N8O7/c1-44(2,3)39-29-40(52(50-39)32-14-12-31(13-15-32)51(4)5)48-43(53)47-37-16-17-38(36-11-9-8-10-35(36)37)59-41-18-19-45-42(49-41)46-30-26-33(55-7)28-34(27-30)58-25-24-57-23-22-56-21-20-54-6/h8-19,26-29H,20-25H2,1-7H3,(H,45,46,49)(H2,47,48,53)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.82E+3n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM334338
PNG
(1-(4-((2-((3-(2-Hydroxyethyl)thio)-5-methoxyphenyl...)
Show SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)C)c4ccccc34)n2)cc(SCCO)c1
Show InChI InChI=1S/C37H37N7O4S/c1-23(2)32-22-34(44(43-32)26-11-9-24(3)10-12-26)41-37(46)40-31-13-14-33(30-8-6-5-7-29(30)31)48-35-15-16-38-36(42-35)39-25-19-27(47-4)21-28(20-25)49-18-17-45/h5-16,19-23,45H,17-18H2,1-4H3,(H,38,39,42)(H2,40,41,46)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 4.83E+3n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM334383
PNG
(1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(...)
Show SMILES COCCOCCOCCN(C)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc(OC)c1
Show InChI InChI=1S/C44H52N8O6/c1-30-12-14-32(15-13-30)52-40(29-39(50-52)44(2,3)4)48-43(53)47-37-16-17-38(36-11-9-8-10-35(36)37)58-41-18-19-45-42(49-41)46-31-26-33(28-34(27-31)55-7)51(5)20-21-56-24-25-57-23-22-54-6/h8-19,26-29H,20-25H2,1-7H3,(H,45,46,49)(H2,47,48,53)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.26E+3n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM334354
PNG
(1-(3-(tert-Butyl)-1-(6-methoxypyridin-3-yl)-1H-pyr...)
Show SMILES COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(OC)nc4)C(C)(C)C)c4ccccc34)n2)cc(OC)c1
Show InChI InChI=1S/C42H48N8O8/c1-42(2,3)36-26-37(50(49-36)29-11-14-38(54-6)44-27-29)47-41(51)46-34-12-13-35(33-10-8-7-9-32(33)34)58-39-15-16-43-40(48-39)45-28-23-30(53-5)25-31(24-28)57-22-21-56-20-19-55-18-17-52-4/h7-16,23-27H,17-22H2,1-6H3,(H,43,45,48)(H2,46,47,51)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.45E+3n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM334353
PNG
(1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(...)
Show SMILES COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc(OC)c1
Show InChI InChI=1S/C43H49N7O7/c1-29-11-13-31(14-12-29)50-39(28-38(49-50)43(2,3)4)47-42(51)46-36-15-16-37(35-10-8-7-9-34(35)36)57-40-17-18-44-41(48-40)45-30-25-32(53-6)27-33(26-30)56-24-23-55-22-21-54-20-19-52-5/h7-18,25-28H,19-24H2,1-6H3,(H,44,45,48)(H2,46,47,51)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6.36E+3n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM334363
PNG
(1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(...)
Show SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc(c1)S(=O)(=O)C1CC1
Show InChI InChI=1S/C39H39N7O5S/c1-24-10-12-26(13-11-24)46-35(23-34(45-46)39(2,3)4)43-38(47)42-32-16-17-33(31-9-7-6-8-30(31)32)51-36-18-19-40-37(44-36)41-25-20-27(50-5)22-29(21-25)52(48,49)28-14-15-28/h6-13,16-23,28H,14-15H2,1-5H3,(H,40,41,44)(H2,42,43,47)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 6.83E+3n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM334346
PNG
(1-(4-((2-((3-(2,5,8,11,14-Pentaoxahexadecan-16-ylo...)
Show SMILES COCCOCCOCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)C)c4ccccc34)n2)cc(OC)c1
Show InChI InChI=1S/C46H55N7O9/c1-32(2)41-31-43(53(52-41)35-12-10-33(3)11-13-35)50-46(54)49-40-14-15-42(39-9-7-6-8-38(39)40)62-44-16-17-47-45(51-44)48-34-28-36(56-5)30-37(29-34)61-27-26-60-25-24-59-23-22-58-21-20-57-19-18-55-4/h6-17,28-32H,18-27H2,1-5H3,(H,47,48,51)(H2,49,50,54)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 7.23E+3n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM334365
PNG
(1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(...)
Show SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c4ccccc34)n2)cc(OCCCN2CCOCC2)c1
Show InChI InChI=1S/C43H48N8O5/c1-29-11-13-31(14-12-29)51-39(28-38(49-51)43(2,3)4)47-42(52)46-36-15-16-37(35-10-7-6-9-34(35)36)56-40-17-18-44-41(48-40)45-30-25-32(53-5)27-33(26-30)55-22-8-19-50-20-23-54-24-21-50/h6-7,9-18,25-28H,8,19-24H2,1-5H3,(H,44,45,48)(H2,46,47,52)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 7.26E+3n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM334375
PNG
(1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(...)
Show SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c(Cl)c3Cl)n2)cc(OCCN2CCOCC2)c1
Show InChI InChI=1S/C38H42Cl2N8O5/c1-24-6-8-26(9-7-24)48-32(23-31(46-48)38(2,3)4)44-37(49)43-29-10-11-30(35(40)34(29)39)53-33-12-13-41-36(45-33)42-25-20-27(50-5)22-28(21-25)52-19-16-47-14-17-51-18-15-47/h6-13,20-23H,14-19H2,1-5H3,(H,41,42,45)(H2,43,44,49)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 7.37E+3n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM334387
PNG
(1-(3-(tert-Butyl)-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(...)
Show SMILES COc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C)c(Cl)c3Cl)n2)cc(OCCOCCOCCO)c1
Show InChI InChI=1S/C38H43Cl2N7O7/c1-24-6-8-26(9-7-24)47-32(23-31(46-47)38(2,3)4)44-37(49)43-29-10-11-30(35(40)34(29)39)54-33-12-13-41-36(45-33)42-25-20-27(50-5)22-28(21-25)53-19-18-52-17-16-51-15-14-48/h6-13,20-23,48H,14-19H2,1-5H3,(H,41,42,45)(H2,43,44,49)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 7.74E+3n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM334356
PNG
(1-(4-((2-((3-Methoxy-5-(2-(2-(2-methoxyethoxyl)eth...)
Show SMILES COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)(C)C(F)(F)F)c4ccccc34)n2)cc(OC)c1
Show InChI InChI=1S/C43H46F3N7O7/c1-28-10-12-30(13-11-28)53-38(27-37(52-53)42(2,3)43(44,45)46)50-41(54)49-35-14-15-36(34-9-7-6-8-33(34)35)60-39-16-17-47-40(51-39)48-29-24-31(56-5)26-32(25-29)59-23-22-58-21-20-57-19-18-55-4/h6-17,24-27H,18-23H2,1-5H3,(H,47,48,51)(H2,49,50,54)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 8.17E+3n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM334327
PNG
(3-(4-((4-(3-(3-Isopropyl-1-(p-tolyl)-1H-pyrazol-5-...)
Show SMILES CC(C)c1cc(NC(=O)Nc2ccc(Oc3ccnc(Nc4cccc(OS(C)(=O)=O)c4)n3)c3ccccc23)n(n1)-c1ccc(C)cc1
Show InChI InChI=1S/C35H33N7O5S/c1-22(2)30-21-32(42(41-30)25-14-12-23(3)13-15-25)39-35(43)38-29-16-17-31(28-11-6-5-10-27(28)29)46-33-18-19-36-34(40-33)37-24-8-7-9-26(20-24)47-48(4,44)45/h5-22H,1-4H3,(H,36,37,40)(H2,38,39,43)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 8.65E+3n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM334329
PNG
(1-(3-Isopropyl-1-(p-tolyl)-1H-pyrazol-5-yl)-3-(4-(...)
Show SMILES COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(C)C)c4ccccc34)n2)cc(OC)c1
Show InChI InChI=1S/C42H47N7O7/c1-28(2)37-27-39(49(48-37)31-12-10-29(3)11-13-31)46-42(50)45-36-14-15-38(35-9-7-6-8-34(35)36)56-40-16-17-43-41(47-40)44-30-24-32(52-5)26-33(25-30)55-23-22-54-21-20-53-19-18-51-4/h6-17,24-28H,18-23H2,1-5H3,(H,43,44,47)(H2,45,46,50)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>8.92E+3n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3


(Homo sapiens (Human))
BDBM334355
PNG
(1-(4-((2-((3-Methoxy-5-(2-(2-(2-methoxyethoxyl)eth...)
Show SMILES COCCOCCOCCOc1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(nn4-c4ccc(C)cc4)C(F)(F)C(F)(F)F)c4ccccc34)n2)cc(OC)c1
Show InChI InChI=1S/C41H40F5N7O7/c1-26-8-10-28(11-9-26)53-36(25-35(52-53)40(42,43)41(44,45)46)50-39(54)49-33-12-13-34(32-7-5-4-6-31(32)33)60-37-14-15-47-38(51-37)48-27-22-29(56-3)24-30(23-27)59-21-20-58-19-18-57-17-16-55-2/h4-15,22-25H,16-21H2,1-3H3,(H,47,48,51)(H2,49,50,54)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 9.54E+3n/an/an/an/an/an/a



RESPIVERT LIMITED; TOPIVERT PHARMA LIMITED

US Patent


Assay Description
The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...


US Patent US9732063 (2017)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 72 total )  |  Next  |  Last  >>
Jump to: