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Found 58 hits of ph data with Target = '11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32525
PNG
(pyridine amide, 33)
Show SMILES O=C(N1CCCC2CCCCC12)c1cccc(n1)-c1ccccc1-c1ccccc1
Show InChI InChI=1S/C27H28N2O/c30-27(29-19-9-13-21-12-4-7-18-26(21)29)25-17-8-16-24(28-25)23-15-6-5-14-22(23)20-10-2-1-3-11-20/h1-3,5-6,8,10-11,14-17,21,26H,4,7,9,12-13,18-19H2
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n/an/a 4.70n/an/an/an/a6.523



Bristol-Myers Squibb Company



Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.069
BindingDB Entry DOI: 10.7270/Q2P26WGT
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32499
PNG
(pyridine amide, 8)
Show SMILES CC1CCN(CC1)C(=O)c1cccc(CS(=O)(=O)c2c(Cl)cccc2Cl)n1
Show InChI InChI=1S/C19H20Cl2N2O3S/c1-13-8-10-23(11-9-13)19(24)17-7-2-4-14(22-17)12-27(25,26)18-15(20)5-3-6-16(18)21/h2-7,13H,8-12H2,1H3
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n/an/a 35n/an/an/an/a6.523



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Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.069
BindingDB Entry DOI: 10.7270/Q2P26WGT
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32524
PNG
(pyridine amide, 32)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cccc(n1)C(=O)N1CCCC2CCCCC12
Show InChI InChI=1S/C22H23F3N2O/c23-22(24,25)17-12-10-15(11-13-17)18-7-3-8-19(26-18)21(28)27-14-4-6-16-5-1-2-9-20(16)27/h3,7-8,10-13,16,20H,1-2,4-6,9,14H2
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n/an/a 3.60n/an/an/an/a6.523



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Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.069
BindingDB Entry DOI: 10.7270/Q2P26WGT
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32523
PNG
(pyridine amide, 31)
Show SMILES [O-][N+](=O)c1ccccc1-c1cccc(n1)C(=O)N1CCCC2CCCCC12
Show InChI InChI=1S/C21H23N3O3/c25-21(23-14-6-8-15-7-1-3-12-19(15)23)18-11-5-10-17(22-18)16-9-2-4-13-20(16)24(26)27/h2,4-5,9-11,13,15,19H,1,3,6-8,12,14H2
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Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.069
BindingDB Entry DOI: 10.7270/Q2P26WGT
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32522
PNG
(pyridine amide, 30)
Show SMILES Cc1ccc(cc1F)-c1cccc(n1)C(=O)N1CCCC(C)(C)C1
Show InChI InChI=1S/C20H23FN2O/c1-14-8-9-15(12-16(14)21)17-6-4-7-18(22-17)19(24)23-11-5-10-20(2,3)13-23/h4,6-9,12H,5,10-11,13H2,1-3H3
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n/an/a 0.100n/an/an/an/a6.523



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Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.069
BindingDB Entry DOI: 10.7270/Q2P26WGT
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32521
PNG
(pyridine amide, 29)
Show SMILES CC1(C)CCCN(C1)C(=O)c1cccc(n1)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C20H21F3N2O2/c1-19(2)11-4-12-25(13-19)18(26)17-6-3-5-16(24-17)14-7-9-15(10-8-14)27-20(21,22)23/h3,5-10H,4,11-13H2,1-2H3
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n/an/a 1.10n/an/an/an/a6.523



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Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.069
BindingDB Entry DOI: 10.7270/Q2P26WGT
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32520
PNG
(pyridine amide, 28)
Show SMILES CC1(C)CCCN(C1)C(=O)c1cccc(n1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C19H21ClN2O/c1-19(2)11-4-12-22(13-19)18(23)17-6-3-5-16(21-17)14-7-9-15(20)10-8-14/h3,5-10H,4,11-13H2,1-2H3
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Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.069
BindingDB Entry DOI: 10.7270/Q2P26WGT
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32519
PNG
(pyridine amide, 27)
Show SMILES CC1(C)CCCN(C1)C(=O)c1cccc(n1)-c1ccccc1Cl
Show InChI InChI=1S/C19H21ClN2O/c1-19(2)11-6-12-22(13-19)18(23)17-10-5-9-16(21-17)14-7-3-4-8-15(14)20/h3-5,7-10H,6,11-13H2,1-2H3
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n/an/a 2.90n/an/an/an/a6.523



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Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.069
BindingDB Entry DOI: 10.7270/Q2P26WGT
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32518
PNG
(pyridine amide, 9)
Show SMILES CC1CCN(CC1)C(=O)c1cccc(n1)-c1ccccc1Cl
Show InChI InChI=1S/C18H19ClN2O/c1-13-9-11-21(12-10-13)18(22)17-8-4-7-16(20-17)14-5-2-3-6-15(14)19/h2-8,13H,9-12H2,1H3
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n/an/a 17n/an/an/an/a6.523



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Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.069
BindingDB Entry DOI: 10.7270/Q2P26WGT
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32517
PNG
(pyridine amide, 14)
Show SMILES CC1CCN(CC1)C(=O)c1cccc(n1)S(=O)(=O)c1ccccc1Cl
Show InChI InChI=1S/C18H19ClN2O3S/c1-13-9-11-21(12-10-13)18(22)15-6-4-8-17(20-15)25(23,24)16-7-3-2-5-14(16)19/h2-8,13H,9-12H2,1H3
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n/an/a 4.67E+3n/an/an/an/a6.523



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Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.069
BindingDB Entry DOI: 10.7270/Q2P26WGT
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32516
PNG
(pyridine amide, 13)
Show SMILES CC1CCN(CC1)C(=O)c1cccc(Nc2ccccc2Cl)n1
Show InChI InChI=1S/C18H20ClN3O/c1-13-9-11-22(12-10-13)18(23)16-7-4-8-17(21-16)20-15-6-3-2-5-14(15)19/h2-8,13H,9-12H2,1H3,(H,20,21)
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Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.069
BindingDB Entry DOI: 10.7270/Q2P26WGT
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32515
PNG
(pyridine amide, 12)
Show SMILES CC1CCN(CC1)C(=O)c1cccc(Oc2ccccc2Cl)n1
Show InChI InChI=1S/C18H19ClN2O2/c1-13-9-11-21(12-10-13)18(22)15-6-4-8-17(20-15)23-16-7-3-2-5-14(16)19/h2-8,13H,9-12H2,1H3
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Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.069
BindingDB Entry DOI: 10.7270/Q2P26WGT
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32514
PNG
(pyridine amide, 11)
Show SMILES CC1CCN(CC1)C(=O)c1cccc(Sc2ccccc2Cl)n1
Show InChI InChI=1S/C18H19ClN2OS/c1-13-9-11-21(12-10-13)18(22)15-6-4-8-17(20-15)23-16-7-3-2-5-14(16)19/h2-8,13H,9-12H2,1H3
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n/an/a 218n/an/an/an/a6.523



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Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.069
BindingDB Entry DOI: 10.7270/Q2P26WGT
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32513
PNG
(pyridine amide, 7)
Show SMILES CC1CCN(CC1)C(=O)c1cccc(COc2c(Cl)cccc2Cl)n1
Show InChI InChI=1S/C19H20Cl2N2O2/c1-13-8-10-23(11-9-13)19(24)17-7-2-4-14(22-17)12-25-18-15(20)5-3-6-16(18)21/h2-7,13H,8-12H2,1H3
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n/an/a 79n/an/an/an/a6.523



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Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.069
BindingDB Entry DOI: 10.7270/Q2P26WGT
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32512
PNG
(pyridine amide, 6)
Show SMILES CC1CCN(CC1)C(=O)c1cccc(CSc2c(Cl)cccc2Cl)n1
Show InChI InChI=1S/C19H20Cl2N2OS/c1-13-8-10-23(11-9-13)19(24)17-7-2-4-14(22-17)12-25-18-15(20)5-3-6-16(18)21/h2-7,13H,8-12H2,1H3
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n/an/a 7.20n/an/an/an/a6.523



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Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.069
BindingDB Entry DOI: 10.7270/Q2P26WGT
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32511
PNG
(pyridine amide, 26)
Show SMILES Clc1cccc(Cl)c1S(=O)(=O)Cc1cncc(c1)C(=O)N1CCOCC1
Show InChI InChI=1S/C17H16Cl2N2O4S/c18-14-2-1-3-15(19)16(14)26(23,24)11-12-8-13(10-20-9-12)17(22)21-4-6-25-7-5-21/h1-3,8-10H,4-7,11H2
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Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.069
BindingDB Entry DOI: 10.7270/Q2P26WGT
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32510
PNG
(pyridine amide, 25)
Show SMILES NC(=O)C1CCN(CC1)C(=O)c1cncc(CS(=O)(=O)c2c(Cl)cccc2Cl)c1
Show InChI InChI=1S/C19H19Cl2N3O4S/c20-15-2-1-3-16(21)17(15)29(27,28)11-12-8-14(10-23-9-12)19(26)24-6-4-13(5-7-24)18(22)25/h1-3,8-10,13H,4-7,11H2,(H2,22,25)
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Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.069
BindingDB Entry DOI: 10.7270/Q2P26WGT
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32509
PNG
(pyridine amide, 24)
Show SMILES Clc1cccc(Cl)c1S(=O)(=O)Cc1cncc(c1)C(=O)N1CCCCC1
Show InChI InChI=1S/C18H18Cl2N2O3S/c19-15-5-4-6-16(20)17(15)26(24,25)12-13-9-14(11-21-10-13)18(23)22-7-2-1-3-8-22/h4-6,9-11H,1-3,7-8,12H2
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Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.069
BindingDB Entry DOI: 10.7270/Q2P26WGT
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32508
PNG
(pyridine amide, 23)
Show SMILES Clc1cccc(Cl)c1S(=O)(=O)Cc1cncc(c1)C(=O)N1CCCCCCCC1
Show InChI InChI=1S/C21H24Cl2N2O3S/c22-18-8-7-9-19(23)20(18)29(27,28)15-16-12-17(14-24-13-16)21(26)25-10-5-3-1-2-4-6-11-25/h7-9,12-14H,1-6,10-11,15H2
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Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.069
BindingDB Entry DOI: 10.7270/Q2P26WGT
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32507
PNG
(pyridine amide, 22)
Show SMILES Clc1cccc(Cl)c1S(=O)(=O)Cc1cncc(c1)C(=O)N1CCCCCCC1
Show InChI InChI=1S/C20H22Cl2N2O3S/c21-17-7-6-8-18(22)19(17)28(26,27)14-15-11-16(13-23-12-15)20(25)24-9-4-2-1-3-5-10-24/h6-8,11-13H,1-5,9-10,14H2
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Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.069
BindingDB Entry DOI: 10.7270/Q2P26WGT
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32506
PNG
(pyridine amide, 21)
Show SMILES Clc1cccc(Cl)c1S(=O)(=O)Cc1cncc(c1)C(=O)N1CCCCCC1
Show InChI InChI=1S/C19H20Cl2N2O3S/c20-16-6-5-7-17(21)18(16)27(25,26)13-14-10-15(12-22-11-14)19(24)23-8-3-1-2-4-9-23/h5-7,10-12H,1-4,8-9,13H2
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n/an/a 21n/an/an/an/a6.523



Bristol-Myers Squibb Company



Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.069
BindingDB Entry DOI: 10.7270/Q2P26WGT
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32505
PNG
(pyridine amide, 20)
Show SMILES Clc1cccc(Cl)c1S(=O)(=O)Cc1cncc(c1)C(=O)N1CCCC1
Show InChI InChI=1S/C17H16Cl2N2O3S/c18-14-4-3-5-15(19)16(14)25(23,24)11-12-8-13(10-20-9-12)17(22)21-6-1-2-7-21/h3-5,8-10H,1-2,6-7,11H2
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n/an/a 2.14E+3n/an/an/an/a6.523



Bristol-Myers Squibb Company



Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.069
BindingDB Entry DOI: 10.7270/Q2P26WGT
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32504
PNG
(pyridine amide, 19)
Show SMILES CC1CCN(CC1)C(=O)c1ccc(CS(=O)(=O)c2c(Cl)cccc2Cl)cn1
Show InChI InChI=1S/C19H20Cl2N2O3S/c1-13-7-9-23(10-8-13)19(24)17-6-5-14(11-22-17)12-27(25,26)18-15(20)3-2-4-16(18)21/h2-6,11,13H,7-10,12H2,1H3
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n/an/a 2.13E+3n/an/an/an/a6.523



Bristol-Myers Squibb Company



Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.069
BindingDB Entry DOI: 10.7270/Q2P26WGT
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32503
PNG
(pyridine amide, 18)
Show SMILES CC1CCN(CC1)C(=O)c1ccc(CS(=O)(=O)c2c(Cl)cccc2Cl)nc1
Show InChI InChI=1S/C19H20Cl2N2O3S/c1-13-7-9-23(10-8-13)19(24)14-5-6-15(22-11-14)12-27(25,26)18-16(20)3-2-4-17(18)21/h2-6,11,13H,7-10,12H2,1H3
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n/an/a 2.05E+3n/an/an/an/a6.523



Bristol-Myers Squibb Company



Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.069
BindingDB Entry DOI: 10.7270/Q2P26WGT
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32502
PNG
(pyridine amide, 17)
Show SMILES CC1CCN(CC1)C(=O)c1cc(CS(=O)(=O)c2c(Cl)cccc2Cl)ccn1
Show InChI InChI=1S/C19H20Cl2N2O3S/c1-13-6-9-23(10-7-13)19(24)17-11-14(5-8-22-17)12-27(25,26)18-15(20)3-2-4-16(18)21/h2-5,8,11,13H,6-7,9-10,12H2,1H3
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n/an/a 319n/an/an/an/a6.523



Bristol-Myers Squibb Company



Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.069
BindingDB Entry DOI: 10.7270/Q2P26WGT
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32501
PNG
(pyridine amide, 16)
Show SMILES CC1CCN(CC1)C(=O)c1ccnc(CS(=O)(=O)c2c(Cl)cccc2Cl)c1
Show InChI InChI=1S/C19H20Cl2N2O3S/c1-13-6-9-23(10-7-13)19(24)14-5-8-22-15(11-14)12-27(25,26)18-16(20)3-2-4-17(18)21/h2-5,8,11,13H,6-7,9-10,12H2,1H3
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n/an/a 106n/an/an/an/a6.523



Bristol-Myers Squibb Company



Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.069
BindingDB Entry DOI: 10.7270/Q2P26WGT
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32500
PNG
(pyridine amide, 15)
Show SMILES CC1CCN(CC1)C(=O)c1cncc(CS(=O)(=O)c2c(Cl)cccc2Cl)c1
Show InChI InChI=1S/C19H20Cl2N2O3S/c1-13-5-7-23(8-6-13)19(24)15-9-14(10-22-11-15)12-27(25,26)18-16(20)3-2-4-17(18)21/h2-4,9-11,13H,5-8,12H2,1H3
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n/an/a 22n/an/an/an/a6.523



Bristol-Myers Squibb Company



Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)


Article DOI: 10.1016/j.bmcl.2008.04.069
BindingDB Entry DOI: 10.7270/Q2P26WGT
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Rattus norvegicus (rat))
BDBM22473
PNG
(2-(hexahydro-2,5-methanopentalen-3a(1H)-ylamino)-1...)
Show SMILES O=C1N=C(NC23CC4CC2CC(C3)C4)SC11CCCC1
Show InChI InChI=1S/C16H22N2OS/c19-13-16(3-1-2-4-16)20-14(17-13)18-15-8-10-5-11(9-15)7-12(15)6-10/h10-12H,1-9H2,(H,17,18,19)
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180 -38.1n/an/an/an/an/a7.222



Biovitrum AB



Assay Description
Enzyme assays were performed using purified recombinant enzymes, incubating with test compound and [3H]cortisone/NADPH. After incubation, the amount ...


J Med Chem 51: 2933-43 (2008)


Article DOI: 10.1021/jm701551j
BindingDB Entry DOI: 10.7270/Q2HM56Q8
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32558
PNG
(arylsulfonylpiperazine, 30)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccccc1Cl
Show InChI InChI=1S/C20H25ClN2O2S/c1-20(2,3)16-8-10-17(11-9-16)26(24,25)23-14-12-22(13-15-23)19-7-5-4-6-18(19)21/h4-11H,12-15H2,1-3H3
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n/an/a 95n/a>1.00E+3n/an/a7.222



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32557
PNG
(arylsulfonylpiperazine, 29)
Show SMILES Cc1ccccc1N1CCN(CC1)S(=O)(=O)c1ccc(cc1)C(C)(C)C
Show InChI InChI=1S/C21H28N2O2S/c1-17-7-5-6-8-20(17)22-13-15-23(16-14-22)26(24,25)19-11-9-18(10-12-19)21(2,3)4/h5-12H,13-16H2,1-4H3
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n/an/a 32n/a 702n/an/a7.222



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32556
PNG
(arylsulfonylpiperazine, 28)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C21H25F3N2O2S/c1-20(2,3)16-8-10-17(11-9-16)29(27,28)26-14-12-25(13-15-26)19-7-5-4-6-18(19)21(22,23)24/h4-11H,12-15H2,1-3H3
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n/an/a 15n/a 971n/an/a7.222



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32555
PNG
(arylsulfonylpiperazine, 27)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ncccc1C#N
Show InChI InChI=1S/C17H18N4O2S/c1-14-4-6-16(7-5-14)24(22,23)21-11-9-20(10-12-21)17-15(13-18)3-2-8-19-17/h2-8H,9-12H2,1H3
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n/an/a 628n/a>1.00E+3n/an/a7.222



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32554
PNG
(arylsulfonylpiperazine, 26)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ncccc1[N+]([O-])=O
Show InChI InChI=1S/C16H18N4O4S/c1-13-4-6-14(7-5-13)25(23,24)19-11-9-18(10-12-19)16-15(20(21)22)3-2-8-17-16/h2-8H,9-12H2,1H3
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n/an/a 291n/a>1.00E+3n/an/a7.222



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32553
PNG
(arylsulfonylpiperazine, 25)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ncccc1Cl
Show InChI InChI=1S/C16H18ClN3O2S/c1-13-4-6-14(7-5-13)23(21,22)20-11-9-19(10-12-20)16-15(17)3-2-8-18-16/h2-8H,9-12H2,1H3
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n/an/a 117n/a>1.00E+3n/an/a7.222



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32552
PNG
(arylsulfonylpiperazine, 24)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ncccc1C
Show InChI InChI=1S/C17H21N3O2S/c1-14-5-7-16(8-6-14)23(21,22)20-12-10-19(11-13-20)17-15(2)4-3-9-18-17/h3-9H,10-13H2,1-2H3
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n/an/a 152n/a>1.00E+3n/an/a7.222



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32551
PNG
(arylsulfonylpiperazine, 23)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccccn1
Show InChI InChI=1S/C16H19N3O2S/c1-14-5-7-15(8-6-14)22(20,21)19-12-10-18(11-13-19)16-4-2-3-9-17-16/h2-9H,10-13H2,1H3
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n/an/a>1.00E+3n/a>1.00E+3n/an/a7.222



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32550
PNG
(arylsulfonylpiperazine, 22)
Show SMILES FC(F)(F)c1cccnc1N1CCN(CC1)S(=O)(=O)c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C16H14Cl2F3N3O2S/c17-11-3-4-14(13(18)10-11)27(25,26)24-8-6-23(7-9-24)15-12(16(19,20)21)2-1-5-22-15/h1-5,10H,6-9H2
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n/an/a 7n/a 241n/an/a7.222



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32549
PNG
(arylsulfonylpiperazine, 21)
Show SMILES FC(F)(F)c1cccc(c1)S(=O)(=O)N1CCN(CC1)c1ncccc1C(F)(F)F
Show InChI InChI=1S/C17H15F6N3O2S/c18-16(19,20)12-3-1-4-13(11-12)29(27,28)26-9-7-25(8-10-26)15-14(17(21,22)23)5-2-6-24-15/h1-6,11H,7-10H2
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n/an/a 64n/a>1.00E+3n/an/a7.222



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32548
PNG
(arylsulfonylpiperazine, 20)
Show SMILES FC(F)(F)c1cccnc1N1CCN(CC1)S(=O)(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C16H15ClF3N3O2S/c17-12-3-1-4-13(11-12)26(24,25)23-9-7-22(8-10-23)15-14(16(18,19)20)5-2-6-21-15/h1-6,11H,7-10H2
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n/an/a 55n/a>1.00E+3n/an/a7.222



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32547
PNG
(arylsulfonylpiperazine, 19)
Show SMILES FC(F)(F)c1cccnc1N1CCN(CC1)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C20H18F3N3O2S/c21-20(22,23)17-8-4-10-24-19(17)25-11-13-26(14-12-25)29(27,28)18-9-3-6-15-5-1-2-7-16(15)18/h1-10H,11-14H2
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n/an/a 13n/a 329n/an/a7.222



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32546
PNG
(arylsulfonylpiperazine, 18)
Show SMILES FC(F)(F)c1cccnc1N1CCN(CC1)S(=O)(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C20H18F3N3O2S/c21-20(22,23)18-6-3-9-24-19(18)25-10-12-26(13-11-25)29(27,28)17-8-7-15-4-1-2-5-16(15)14-17/h1-9,14H,10-13H2
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Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32545
PNG
(arylsulfonylpiperazine, 17)
Show SMILES FC(F)(F)c1cccnc1N1CCN(CC1)S(=O)(=O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C22H20F3N3O2S/c23-22(24,25)20-7-4-12-26-21(20)27-13-15-28(16-14-27)31(29,30)19-10-8-18(9-11-19)17-5-2-1-3-6-17/h1-12H,13-16H2
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n/an/a 74n/a 603n/an/a7.222



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32544
PNG
(arylsulfonylpiperazine, 16)
Show SMILES FC(F)(F)c1cccnc1N1CCN(CC1)S(=O)(=O)c1ccc(cc1)C#N
Show InChI InChI=1S/C17H15F3N4O2S/c18-17(19,20)15-2-1-7-22-16(15)23-8-10-24(11-9-23)27(25,26)14-5-3-13(12-21)4-6-14/h1-7H,8-11H2
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n/an/a 50n/a 978n/an/a7.222



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32543
PNG
(arylsulfonylpiperazine, 15)
Show SMILES [O-][N+](=O)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ncccc1C(F)(F)F
Show InChI InChI=1S/C16H15F3N4O4S/c17-16(18,19)14-2-1-7-20-15(14)21-8-10-22(11-9-21)28(26,27)13-5-3-12(4-6-13)23(24)25/h1-7H,8-11H2
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n/an/a 37n/a 922n/an/a7.222



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32542
PNG
(arylsulfonylpiperazine, 14)
Show SMILES COc1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ncccc1C(F)(F)F
Show InChI InChI=1S/C17H18F3N3O3S/c1-26-13-4-6-14(7-5-13)27(24,25)23-11-9-22(10-12-23)16-15(17(18,19)20)3-2-8-21-16/h2-8H,9-12H2,1H3
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n/an/a 19n/a 456n/an/a7.222



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32541
PNG
(arylsulfonylpiperazine, 13)
Show SMILES FC(F)(F)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ncccc1C(F)(F)F
Show InChI InChI=1S/C17H15F6N3O2S/c18-16(19,20)12-3-5-13(6-4-12)29(27,28)26-10-8-25(9-11-26)15-14(17(21,22)23)2-1-7-24-15/h1-7H,8-11H2
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n/an/a 14n/a 727n/an/a7.222



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32540
PNG
(arylsulfonylpiperazine, 12)
Show SMILES FC(F)(F)c1cccnc1N1CCN(CC1)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C16H15ClF3N3O2S/c17-12-3-5-13(6-4-12)26(24,25)23-10-8-22(9-11-23)15-14(16(18,19)20)2-1-7-21-15/h1-7H,8-11H2
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n/an/a 14n/a 518n/an/a7.222



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32539
PNG
(arylsulfonylpiperazine, 11)
Show SMILES Fc1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ncccc1C(F)(F)F
Show InChI InChI=1S/C16H15F4N3O2S/c17-12-3-5-13(6-4-12)26(24,25)23-10-8-22(9-11-23)15-14(16(18,19)20)2-1-7-21-15/h1-7H,8-11H2
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n/an/a 46n/a 667n/an/a7.222



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32538
PNG
(arylsulfonylpiperazine, 10)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ncccc1C(F)(F)F
Show InChI InChI=1S/C20H24F3N3O2S/c1-19(2,3)15-6-8-16(9-7-15)29(27,28)26-13-11-25(12-14-26)18-17(20(21,22)23)5-4-10-24-18/h4-10H,11-14H2,1-3H3
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n/an/a 4n/a 201n/an/a7.222



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32537
PNG
(arylsulfonylpiperazine, 9)
Show SMILES CC(C)c1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ncccc1C(F)(F)F
Show InChI InChI=1S/C19H22F3N3O2S/c1-14(2)15-5-7-16(8-6-15)28(26,27)25-12-10-24(11-13-25)18-17(19(20,21)22)4-3-9-23-18/h3-9,14H,10-13H2,1-2H3
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n/an/a 15n/a 556n/an/a7.222



Amgen Inc.



Assay Description
Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...


Bioorg Med Chem Lett 18: 3513-6 (2008)


Article DOI: 10.1016/j.bmcl.2008.05.025
BindingDB Entry DOI: 10.7270/Q2J964Q1
More data for this
Ligand-Target Pair
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