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Compile Data Set for Download or QSAR

Found 5 hits of ph data with Target = '15-Lipoxygenase (LoxA)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
15-Lipoxygenase (LoxA)


(Pseudomonas aeruginosa)
BDBM50329323
PNG
(4-(5-(Naphthalen-1-yl)-1,3,4-oxadiazol-2-ylthio)bu...)
Show SMILES O=C(OCC#CCSc1nnc(o1)-c1cccc2ccccc12)c1ccccc1
Show InChI InChI=1S/C23H16N2O3S/c26-22(18-10-2-1-3-11-18)27-15-6-7-16-29-23-25-24-21(28-23)20-14-8-12-17-9-4-5-13-19(17)20/h1-5,8-14H,15-16H2
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UniChem

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Article
PubMed
n/an/a 10n/an/an/an/a7.025



University of California, Santa Cruz



Assay Description
The one-point inhibition percentages were determined for human LOX inhibitors by following the formation of the conjugated diene product at 234 nm (&...


Biochemistry 55: 3329-40 (2016)


Article DOI: 10.1021/acs.biochem.6b00338
BindingDB Entry DOI: 10.7270/Q21N7ZXT
More data for this
Ligand-Target Pair
15-Lipoxygenase (LoxA)


(Pseudomonas aeruginosa)
BDBM190650
PNG
(LOX inhibitor, MLS000545091 | PT91)
Show SMILES CCCCCCc1ccc(Oc2ccccc2Cl)c(O)c1
Show InChI InChI=1S/C14H15ClN2O/c15-12-8-6-11(7-9-12)14-17-16-13(18-14)10-4-2-1-3-5-10/h6-10H,1-5H2
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PC sid
PDB
UniChem
Article
PubMed
n/an/a 2.60E+3n/an/an/an/a7.025



University of California, Santa Cruz



Assay Description
The one-point inhibition percentages were determined for human LOX inhibitors by following the formation of the conjugated diene product at 234 nm (&...


Biochemistry 55: 3329-40 (2016)


Article DOI: 10.1021/acs.biochem.6b00338
BindingDB Entry DOI: 10.7270/Q21N7ZXT
More data for this
Ligand-Target Pair
15-Lipoxygenase (LoxA)


(Pseudomonas aeruginosa)
BDBM32020
PNG
(4-[4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]pyro...)
Show SMILES CC(Cc1ccc(O)c(O)c1)C(C)Cc1ccc(O)c(O)c1
Show InChI InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3
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Article
PubMed
n/an/a 500n/an/an/an/a7.025



University of California, Santa Cruz



Assay Description
The one-point inhibition percentages were determined for human LOX inhibitors by following the formation of the conjugated diene product at 234 nm (&...


Biochemistry 55: 3329-40 (2016)


Article DOI: 10.1021/acs.biochem.6b00338
BindingDB Entry DOI: 10.7270/Q21N7ZXT
More data for this
Ligand-Target Pair
15-Lipoxygenase (LoxA)


(Pseudomonas aeruginosa)
BDBM190652
PNG
(LOX inhibitor, 13 | PT171)
Show SMILES CCCCCCc1ccn(Cc2ccccc2C)c(=O)c1
Show InChI InChI=1S/C23H24ClN3O2/c1-17(28)26-11-13-27(14-12-26)21-7-5-20(6-8-21)25-16-22-9-10-23(29-22)18-3-2-4-19(24)15-18/h2-10,15,25H,11-14,16H2,1H3
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GoogleScholar
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PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 520n/an/an/an/a7.025



University of California, Santa Cruz



Assay Description
The one-point inhibition percentages were determined for human LOX inhibitors by following the formation of the conjugated diene product at 234 nm (&...


Biochemistry 55: 3329-40 (2016)


Article DOI: 10.1021/acs.biochem.6b00338
BindingDB Entry DOI: 10.7270/Q21N7ZXT
More data for this
Ligand-Target Pair
15-Lipoxygenase (LoxA)


(Pseudomonas aeruginosa)
BDBM190651
PNG
(LOX inhibitor, 5 | PT113)
Show SMILES CCCCCCc1ccc(Oc2ccccc2F)c(O)c1
Show InChI InChI=1S/C18H21FO2/c1-2-3-4-5-8-14-11-12-18(16(20)13-14)21-17-10-7-6-9-15(17)19/h6-7,9-13,20H,2-5,8H2,1H3
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.00E+3n/an/an/an/a7.025



University of California, Santa Cruz



Assay Description
The one-point inhibition percentages were determined for human LOX inhibitors by following the formation of the conjugated diene product at 234 nm (&...


Biochemistry 55: 3329-40 (2016)


Article DOI: 10.1021/acs.biochem.6b00338
BindingDB Entry DOI: 10.7270/Q21N7ZXT
More data for this
Ligand-Target Pair