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Compile Data Set for Download or QSAR

Found 128 hits of ph data with Target = '5-Hydroxytryptamine receptor 6 (5-HT6)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM34145
PNG
(pyrrolidinylindole, (R)-5b)
Show SMILES CN1CCC[C@@H]1Cc1c[nH]c2ccc(NS(=O)(=O)c3ccc(cc3)C(F)(F)F)cc12
Show InChI InChI=1S/C21H22F3N3O2S/c1-27-10-2-3-17(27)11-14-13-25-20-9-6-16(12-19(14)20)26-30(28,29)18-7-4-15(5-8-18)21(22,23)24/h4-9,12-13,17,25-26H,2-3,10-11H2,1H3/t17-/m1/s1
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0.400 -55.8n/an/a 4.5n/an/a7.437



Universitat de Barcelona



Assay Description
Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...


Bioorg Med Chem 17: 7387-97 (2009)


Article DOI: 10.1016/j.bmc.2009.08.006
BindingDB Entry DOI: 10.7270/Q2RR1WKS
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM50314762
PNG
(5-methyl-2-(methylthio)-3-(phenylsulfonyl)-6,7,8,9...)
Show SMILES CSc1nn2c3CCCCc3c(C)nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C18H19N3O2S2/c1-12-14-10-6-7-11-15(14)21-17(19-12)16(18(20-21)24-2)25(22,23)13-8-4-3-5-9-13/h3-5,8-9H,6-7,10-11H2,1-2H3
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0.440 -54.3 0.948n/an/an/an/a7.430



TBA

US Patent


Assay Description
Determination of tested compounds binding with 5-HT6 receptors was carried out according to the method described in [Monsma F J Jr, Shen Y, Ward R P,...


US Patent US8629154 (2014)


BindingDB Entry DOI: 10.7270/Q20R9N2C
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM50314759
PNG
(2-(methylthio)-3-(phenylsulfonyl)-7,8-dihydro-6H-c...)
Show SMILES CSc1nn2c3CCCc3cnc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C16H15N3O2S2/c1-22-16-14(23(20,21)12-7-3-2-4-8-12)15-17-10-11-6-5-9-13(11)19(15)18-16/h2-4,7-8,10H,5-6,9H2,1H3
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0.458 -54.2 0.986n/an/an/an/a7.430



TBA

US Patent


Assay Description
Determination of tested compounds binding with 5-HT6 receptors was carried out according to the method described in [Monsma F J Jr, Shen Y, Ward R P,...


US Patent US8629154 (2014)


BindingDB Entry DOI: 10.7270/Q20R9N2C
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM28574
PNG
(1-sulfonylindazole, 6c | 3-amino-N-[1-(naphthalene...)
Show SMILES NCCC(=O)Nc1ccc2cnn(c2c1)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C20H18N4O3S/c21-11-10-20(25)23-16-9-8-15-13-22-24(18(15)12-16)28(26,27)19-7-3-5-14-4-1-2-6-17(14)19/h1-9,12-13H,10-11,21H2,(H,23,25)
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0.5 -52.6n/an/an/an/an/a7.422



Wyeth Research



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...


Bioorg Med Chem Lett 19: 2413-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.071
BindingDB Entry DOI: 10.7270/Q28K77CF
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM50314760
PNG
(2-(methylthio)-3-(phenylsulfonyl)-6,7,8,9-tetrahyd...)
Show SMILES CSc1nn2c3CCCCc3cnc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C17H17N3O2S2/c1-23-17-15(24(21,22)13-8-3-2-4-9-13)16-18-11-12-7-5-6-10-14(12)20(16)19-17/h2-4,8-9,11H,5-7,10H2,1H3
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0.549 -53.7 1.18n/an/an/an/a7.430



TBA

US Patent


Assay Description
Determination of tested compounds binding with 5-HT6 receptors was carried out according to the method described in [Monsma F J Jr, Shen Y, Ward R P,...


US Patent US8629154 (2014)


BindingDB Entry DOI: 10.7270/Q20R9N2C
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM50314763
PNG
(9-methyl-2-(methylthio)-3-(phenylsulfonyl)-5,6,7,8...)
Show SMILES CSc1nn2c(C)c3CCCCc3nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C18H19N3O2S2/c1-12-14-10-6-7-11-15(14)19-17-16(18(24-2)20-21(12)17)25(22,23)13-8-4-3-5-9-13/h3-5,8-9H,6-7,10-11H2,1-2H3
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0.680 -53.2 1.46n/an/an/an/a7.430



TBA

US Patent


Assay Description
Determination of tested compounds binding with 5-HT6 receptors was carried out according to the method described in [Monsma F J Jr, Shen Y, Ward R P,...


US Patent US8629154 (2014)


BindingDB Entry DOI: 10.7270/Q20R9N2C
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM34143
PNG
(CHEMBL175835 | E-6837)
Show SMILES CN(C)CCc1c[nH]c2ccc(NS(=O)(=O)c3ccc4c(Cl)cccc4c3)cc12
Show InChI InChI=1S/C22H22ClN3O2S/c1-26(2)11-10-16-14-24-22-9-6-17(13-20(16)22)25-29(27,28)18-7-8-19-15(12-18)4-3-5-21(19)23/h3-9,12-14,24-25H,10-11H2,1-2H3
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0.700 -54.4n/an/a 0.290n/an/a7.437



Universitat de Barcelona



Assay Description
Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...


Bioorg Med Chem 17: 7387-97 (2009)


Article DOI: 10.1016/j.bmc.2009.08.006
BindingDB Entry DOI: 10.7270/Q2RR1WKS
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM50130275
PNG
(4-(3-(2-(dimethylamino)ethyl)-1H-indol-1-ylsulfony...)
Show SMILES CN(C)CCc1cn(c2ccccc12)S(=O)(=O)c1ccc(N)cc1
Show InChI InChI=1S/C18H21N3O2S/c1-20(2)12-11-14-13-21(18-6-4-3-5-17(14)18)24(22,23)16-9-7-15(19)8-10-16/h3-10,13H,11-12,19H2,1-2H3
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0.800n/an/an/an/an/an/a7.4n/a



Virginia Commonwealth University



Assay Description
The h5-HT6 radioligand binding assays were performed as previously described. In brief, h5-HT6 cDNA was transiently expressed in HEK-293 cells using...


Medicinal Chemistry Research 14: 1-18 (2005)


BindingDB Entry DOI: 10.7270/Q2NG4P78
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM34144
PNG
((R)-5a | WAY-466)
Show SMILES Ic1ccccc1S(=O)(=O)Nc1ccc2[nH]cc(C[C@H]3CCCN3)c2c1
Show InChI InChI=1S/C19H20IN3O2S/c20-17-5-1-2-6-19(17)26(24,25)23-15-7-8-18-16(11-15)13(12-22-18)10-14-4-3-9-21-14/h1-2,5-8,11-12,14,21-23H,3-4,9-10H2/t14-/m1/s1
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1 -53.4n/an/a 0.400n/an/a7.437



Universitat de Barcelona



Assay Description
Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...


Bioorg Med Chem 17: 7387-97 (2009)


Article DOI: 10.1016/j.bmc.2009.08.006
BindingDB Entry DOI: 10.7270/Q2RR1WKS
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM21351
PNG
(4-{[3-(2-aminoethyl)-1H-indole-1-]sulfonyl}aniline...)
Show SMILES NCCc1cn(c2ccccc12)S(=O)(=O)c1ccc(N)cc1
Show InChI InChI=1S/C16H17N3O2S/c17-10-9-12-11-19(16-4-2-1-3-15(12)16)22(20,21)14-7-5-13(18)6-8-14/h1-8,11H,9-10,17-18H2
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1 -50.9n/an/a 91n/an/a7.422



Wyeth Research



Assay Description
IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...


J Med Chem 50: 5535-8 (2007)


Article DOI: 10.1021/jm070521y
BindingDB Entry DOI: 10.7270/Q23R0R5G
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM34147
PNG
(CHEMBL425196 | pyrrolidinylindole, 6)
Show SMILES CN1CCC(C1)c1cn(c2ccccc12)S(=O)(=O)c1ccccc1Br
Show InChI InChI=1S/C19H19BrN2O2S/c1-21-11-10-14(12-21)16-13-22(18-8-4-2-6-15(16)18)25(23,24)19-9-5-3-7-17(19)20/h2-9,13-14H,10-12H2,1H3
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1 -53.4n/an/a 53.3n/an/a7.437



Universitat de Barcelona



Assay Description
Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...


Bioorg Med Chem 17: 7387-97 (2009)


Article DOI: 10.1016/j.bmc.2009.08.006
BindingDB Entry DOI: 10.7270/Q2RR1WKS
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM28575
PNG
(1-sulfonylindazole, 6d | 3-(methylamino)-N-[1-(nap...)
Show SMILES CNCCC(=O)Nc1ccc2cnn(c2c1)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C21H20N4O3S/c1-22-12-11-21(26)24-17-10-9-16-14-23-25(19(16)13-17)29(27,28)20-8-4-6-15-5-2-3-7-18(15)20/h2-10,13-14,22H,11-12H2,1H3,(H,24,26)
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1.20 -50.4n/an/an/an/an/a7.422



Wyeth Research



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...


Bioorg Med Chem Lett 19: 2413-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.071
BindingDB Entry DOI: 10.7270/Q28K77CF
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM28580
PNG
(1-sulfonylindazole, 7b | N-[1-(naphthalene-1-sulfo...)
Show SMILES O=C(Nc1ccc2cnn(c2c1)S(=O)(=O)c1cccc2ccccc12)C1CCCNC1
Show InChI InChI=1S/C23H22N4O3S/c28-23(18-7-4-12-24-14-18)26-19-11-10-17-15-25-27(21(17)13-19)31(29,30)22-9-3-6-16-5-1-2-8-20(16)22/h1-3,5-6,8-11,13,15,18,24H,4,7,12,14H2,(H,26,28)
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1.30 -50.2n/an/an/an/an/a7.422



Wyeth Research



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...


Bioorg Med Chem Lett 19: 2413-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.071
BindingDB Entry DOI: 10.7270/Q28K77CF
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM28576
PNG
(1-sulfonylindazole, 6e | 3-(dimethylamino)-N-[1-(n...)
Show SMILES CN(C)CCC(=O)Nc1ccc2cnn(c2c1)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C22H22N4O3S/c1-25(2)13-12-22(27)24-18-11-10-17-15-23-26(20(17)14-18)30(28,29)21-9-5-7-16-6-3-4-8-19(16)21/h3-11,14-15H,12-13H2,1-2H3,(H,24,27)
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1.80 -49.4n/an/an/an/an/a7.422



Wyeth Research



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...


Bioorg Med Chem Lett 19: 2413-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.071
BindingDB Entry DOI: 10.7270/Q28K77CF
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM21358
PNG
(2-[1-({6-chloroimidazo[2,1-b][1,3]thiazole-5-}sulf...)
Show SMILES NCCc1cn(c2ccccc12)S(=O)(=O)c1c(Cl)nc2sccn12
Show InChI InChI=1S/C15H13ClN4O2S2/c16-13-14(19-7-8-23-15(19)18-13)24(21,22)20-9-10(5-6-17)11-3-1-2-4-12(11)20/h1-4,7-9H,5-6,17H2
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2 -49.2n/an/a 6.5n/an/a7.422



Wyeth Research



Assay Description
IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...


J Med Chem 50: 5535-8 (2007)


Article DOI: 10.1021/jm070521y
BindingDB Entry DOI: 10.7270/Q23R0R5G
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM34141
PNG
(CHEMBL76237 | MS-245)
Show SMILES COc1ccc2n(cc(CCN(C)C)c2c1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C19H22N2O3S/c1-20(2)12-11-15-14-21(19-10-9-16(24-3)13-18(15)19)25(22,23)17-7-5-4-6-8-17/h4-10,13-14H,11-12H2,1-3H3
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2 -51.6n/an/an/an/an/a7.437



Universitat de Barcelona



Assay Description
Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...


Bioorg Med Chem 17: 7387-97 (2009)


Article DOI: 10.1016/j.bmc.2009.08.006
BindingDB Entry DOI: 10.7270/Q2RR1WKS
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM34148
PNG
(CHEMBL371292 | piperidinylindole, 7)
Show SMILES O=S(=O)(c1ccccc1)n1cc(C2CCCNC2)c2ccccc12
Show InChI InChI=1S/C19H20N2O2S/c22-24(23,16-8-2-1-3-9-16)21-14-18(15-7-6-12-20-13-15)17-10-4-5-11-19(17)21/h1-5,8-11,14-15,20H,6-7,12-13H2
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2 -51.6n/an/a 24n/an/a7.437



Universitat de Barcelona



Assay Description
Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...


Bioorg Med Chem 17: 7387-97 (2009)


Article DOI: 10.1016/j.bmc.2009.08.006
BindingDB Entry DOI: 10.7270/Q2RR1WKS
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM21358
PNG
(2-[1-({6-chloroimidazo[2,1-b][1,3]thiazole-5-}sulf...)
Show SMILES NCCc1cn(c2ccccc12)S(=O)(=O)c1c(Cl)nc2sccn12
Show InChI InChI=1S/C15H13ClN4O2S2/c16-13-14(19-7-8-23-15(19)18-13)24(21,22)20-9-10(5-6-17)11-3-1-2-4-12(11)20/h1-4,7-9H,5-6,17H2
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2 -51.6n/an/a 6.5n/an/a7.437



Universitat de Barcelona



Assay Description
Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...


Bioorg Med Chem 17: 7387-97 (2009)


Article DOI: 10.1016/j.bmc.2009.08.006
BindingDB Entry DOI: 10.7270/Q2RR1WKS
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM28577
PNG
(1-sulfonylindazole, 6f | 3-(diethylamino)-N-[1-(na...)
Show SMILES CCN(CC)CCC(=O)Nc1ccc2cnn(c2c1)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C24H26N4O3S/c1-3-27(4-2)15-14-24(29)26-20-13-12-19-17-25-28(22(19)16-20)32(30,31)23-11-7-9-18-8-5-6-10-21(18)23/h5-13,16-17H,3-4,14-15H2,1-2H3,(H,26,29)
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2.10 -49.0n/an/an/an/an/a7.422



Wyeth Research



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...


Bioorg Med Chem Lett 19: 2413-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.071
BindingDB Entry DOI: 10.7270/Q28K77CF
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM34152
PNG
(CHEMBL362628 | E-6801)
Show SMILES CN(C)CCc1c[nH]c2ccc(NS(=O)(=O)c3c(Cl)nc4sccn34)cc12
Show InChI InChI=1S/C17H18ClN5O2S2/c1-22(2)6-5-11-10-19-14-4-3-12(9-13(11)14)21-27(24,25)16-15(18)20-17-23(16)7-8-26-17/h3-4,7-10,19,21H,5-6H2,1-2H3
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2.20 -51.4n/an/an/an/an/a7.437



Universitat de Barcelona



Assay Description
Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...


Bioorg Med Chem 17: 7387-97 (2009)


Article DOI: 10.1016/j.bmc.2009.08.006
BindingDB Entry DOI: 10.7270/Q2RR1WKS
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM28579
PNG
(1-sulfonylindazole, 7a | N-[1-(naphthalene-1-sulfo...)
Show SMILES O=C(Nc1ccc2cnn(c2c1)S(=O)(=O)c1cccc2ccccc12)C1CCNCC1
Show InChI InChI=1S/C23H22N4O3S/c28-23(17-10-12-24-13-11-17)26-19-9-8-18-15-25-27(21(18)14-19)31(29,30)22-7-3-5-16-4-1-2-6-20(16)22/h1-9,14-15,17,24H,10-13H2,(H,26,28)
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2.30 -48.8n/an/an/an/an/a7.422



Wyeth Research



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...


Bioorg Med Chem Lett 19: 2413-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.071
BindingDB Entry DOI: 10.7270/Q28K77CF
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM34149
PNG
(CHEMBL94422 | N-benzenesulfonylgramine antagonist,...)
Show SMILES CN(C)Cc1cn(c2ccccc12)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C17H18N2O2S/c1-18(2)12-14-13-19(17-11-7-6-10-16(14)17)22(20,21)15-8-4-3-5-9-15/h3-11,13H,12H2,1-2H3
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3 -50.6n/an/a 880n/an/a7.437



Universitat de Barcelona



Assay Description
Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...


Bioorg Med Chem 17: 7387-97 (2009)


Article DOI: 10.1016/j.bmc.2009.08.006
BindingDB Entry DOI: 10.7270/Q2RR1WKS
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM34156
PNG
(indenylsulfonamide, 28)
Show SMILES CN1CCC(C1)C1=CCc2ccc(NS(=O)(=O)c3c(Cl)nc4sccn34)cc12
Show InChI InChI=1S/C19H19ClN4O2S2/c1-23-7-6-13(11-23)15-5-3-12-2-4-14(10-16(12)15)22-28(25,26)18-17(20)21-19-24(18)8-9-27-19/h2,4-5,8-10,13,22H,3,6-7,11H2,1H3
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3 -50.6 1.60E+3n/an/an/an/a7.437



Universitat de Barcelona



Assay Description
Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...


Bioorg Med Chem 17: 7387-97 (2009)


Article DOI: 10.1016/j.bmc.2009.08.006
BindingDB Entry DOI: 10.7270/Q2RR1WKS
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM34153
PNG
(CHEMBL476006 | indenylsulfonamide, 14)
Show SMILES CN(C)CCC1=C(C)Cc2ccc(NS(=O)(=O)c3c(Cl)nc4sccn34)cc12
Show InChI InChI=1S/C19H21ClN4O2S2/c1-12-10-13-4-5-14(11-16(13)15(12)6-7-23(2)3)22-28(25,26)18-17(20)21-19-24(18)8-9-27-19/h4-5,8-9,11,22H,6-7,10H2,1-3H3
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4.5 -49.6n/an/an/an/an/a7.437



Universitat de Barcelona



Assay Description
Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...


Bioorg Med Chem 17: 7387-97 (2009)


Article DOI: 10.1016/j.bmc.2009.08.006
BindingDB Entry DOI: 10.7270/Q2RR1WKS
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM21354
PNG
(2-{1-[(5-chlorothiophene-2-)sulfonyl]-1H-indol-3-y...)
Show SMILES NCCc1cn(c2ccccc12)S(=O)(=O)c1ccc(Cl)s1
Show InChI InChI=1S/C14H13ClN2O2S2/c15-13-5-6-14(20-13)21(18,19)17-9-10(7-8-16)11-3-1-2-4-12(11)17/h1-6,9H,7-8,16H2
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6 -46.5n/an/a 181n/an/a7.422



Wyeth Research



Assay Description
IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...


J Med Chem 50: 5535-8 (2007)


Article DOI: 10.1021/jm070521y
BindingDB Entry DOI: 10.7270/Q23R0R5G
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM21345
PNG
(2-{1-[(3-chlorobenzene)sulfonyl]-1H-indol-3-yl}eth...)
Show SMILES NCCc1cn(c2ccccc12)S(=O)(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C16H15ClN2O2S/c17-13-4-3-5-14(10-13)22(20,21)19-11-12(8-9-18)15-6-1-2-7-16(15)19/h1-7,10-11H,8-9,18H2
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6 -46.5n/an/a 109n/an/a7.422



Wyeth Research



Assay Description
IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...


J Med Chem 50: 5535-8 (2007)


Article DOI: 10.1021/jm070521y
BindingDB Entry DOI: 10.7270/Q23R0R5G
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM21353
PNG
(2-{1-[(3,4-dimethoxybenzene)sulfonyl]-1H-indol-3-y...)
Show SMILES COc1ccc(cc1OC)S(=O)(=O)n1cc(CCN)c2ccccc12
Show InChI InChI=1S/C18H20N2O4S/c1-23-17-8-7-14(11-18(17)24-2)25(21,22)20-12-13(9-10-19)15-5-3-4-6-16(15)20/h3-8,11-12H,9-10,19H2,1-2H3
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7 -46.1n/an/a 17.5n/an/a7.422



Wyeth Research



Assay Description
IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...


J Med Chem 50: 5535-8 (2007)


Article DOI: 10.1021/jm070521y
BindingDB Entry DOI: 10.7270/Q23R0R5G
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM21355
PNG
(2-{1-[(5-bromothiophene-2-)sulfonyl]-1H-indol-3-yl...)
Show SMILES NCCc1cn(c2ccccc12)S(=O)(=O)c1ccc(Br)s1
Show InChI InChI=1S/C14H13BrN2O2S2/c15-13-5-6-14(20-13)21(18,19)17-9-10(7-8-16)11-3-1-2-4-12(11)17/h1-6,9H,7-8,16H2
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7 -46.1n/an/a 54n/an/a7.422



Wyeth Research



Assay Description
IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...


J Med Chem 50: 5535-8 (2007)


Article DOI: 10.1021/jm070521y
BindingDB Entry DOI: 10.7270/Q23R0R5G
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM28572
PNG
(1-sulfonylindazole, 6a | 3-amino-N-[1-(naphthalene...)
Show SMILES NCCC(=O)Nc1cccc2n(ncc12)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C20H18N4O3S/c21-12-11-20(25)23-17-8-4-9-18-16(17)13-22-24(18)28(26,27)19-10-3-6-14-5-1-2-7-15(14)19/h1-10,13H,11-12,21H2,(H,23,25)
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7.90 -45.8n/an/an/an/an/a7.422



Wyeth Research



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...


Bioorg Med Chem Lett 19: 2413-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.071
BindingDB Entry DOI: 10.7270/Q28K77CF
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM50314761
PNG
(2-Methylsulfanyl-3-phenylsulfonyl-5,6,7,8-tetrahyd...)
Show SMILES CSc1nn2cc3CCCCc3nc2c1S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C17H17N3O2S2/c1-23-17-15(24(21,22)13-8-3-2-4-9-13)16-18-14-10-6-5-7-12(14)11-20(16)19-17/h2-4,8-9,11H,5-7,10H2,1H3
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7.97 -47.0 17.2n/an/an/an/a7.430



TBA

US Patent


Assay Description
Determination of tested compounds binding with 5-HT6 receptors was carried out according to the method described in [Monsma F J Jr, Shen Y, Ward R P,...


US Patent US8629154 (2014)


BindingDB Entry DOI: 10.7270/Q20R9N2C
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM21349
PNG
(2-{1-[(4-methylbenzene)sulfonyl]-1H-indol-3-yl}eth...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)n1cc(CCN)c2ccccc12
Show InChI InChI=1S/C17H18N2O2S/c1-13-6-8-15(9-7-13)22(20,21)19-12-14(10-11-18)16-4-2-3-5-17(16)19/h2-9,12H,10-11,18H2,1H3
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8 -45.7n/an/a 191n/an/a7.422



Wyeth Research



Assay Description
IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...


J Med Chem 50: 5535-8 (2007)


Article DOI: 10.1021/jm070521y
BindingDB Entry DOI: 10.7270/Q23R0R5G
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM21365
PNG
(3-[(E)-{1-[1-(benzenesulfonyl)-1H-indol-3-yl]ethyl...)
Show SMILES CC(=NN=C(N)N)c1cn(c2ccccc12)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C17H17N5O2S/c1-12(20-21-17(18)19)15-11-22(16-10-6-5-9-14(15)16)25(23,24)13-7-3-2-4-8-13/h2-11H,1H3,(H4,18,19,21)
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8 -45.7n/an/an/an/an/a7.422



Wyeth Research



Assay Description
IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...


J Med Chem 50: 5535-8 (2007)


Article DOI: 10.1021/jm070521y
BindingDB Entry DOI: 10.7270/Q23R0R5G
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM21341
PNG
(2-[1-(benzenesulfonyl)-1H-indol-3-yl]ethan-1-amine...)
Show SMILES NCCc1cn(c2ccccc12)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C16H16N2O2S/c17-11-10-13-12-18(16-9-5-4-8-15(13)16)21(19,20)14-6-2-1-3-7-14/h1-9,12H,10-11,17H2
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10 -45.2n/an/a 73n/an/a7.422



Wyeth Research



Assay Description
IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...


J Med Chem 50: 5535-8 (2007)


Article DOI: 10.1021/jm070521y
BindingDB Entry DOI: 10.7270/Q23R0R5G
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM21347
PNG
(2-{1-[(4-chlorobenzene)sulfonyl]-1H-indol-3-yl}eth...)
Show SMILES NCCc1cn(c2ccccc12)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C16H15ClN2O2S/c17-13-5-7-14(8-6-13)22(20,21)19-11-12(9-10-18)15-3-1-2-4-16(15)19/h1-8,11H,9-10,18H2
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10 -45.2n/an/a 174n/an/a7.422



Wyeth Research



Assay Description
IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...


J Med Chem 50: 5535-8 (2007)


Article DOI: 10.1021/jm070521y
BindingDB Entry DOI: 10.7270/Q23R0R5G
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM21357
PNG
(5-thiazolylsulfonyl tryptamine, 11p | 5-{[3-(2-ami...)
Show SMILES Cc1nc(N)sc1S(=O)(=O)n1cc(CCN)c2ccccc12
Show InChI InChI=1S/C14H16N4O2S2/c1-9-13(21-14(16)17-9)22(19,20)18-8-10(6-7-15)11-4-2-3-5-12(11)18/h2-5,8H,6-7,15H2,1H3,(H2,16,17)
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10 -45.2n/an/a 9.60n/an/a7.422



Wyeth Research



Assay Description
IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...


J Med Chem 50: 5535-8 (2007)


Article DOI: 10.1021/jm070521y
BindingDB Entry DOI: 10.7270/Q23R0R5G
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM34151
PNG
(CHEMBL372109 | N-arenesulfonylindole antagonist, 1...)
Show SMILES Nc1ccc(cc1)S(=O)(=O)n1ccc2ccccc12
Show InChI InChI=1S/C14H12N2O2S/c15-12-5-7-13(8-6-12)19(17,18)16-10-9-11-3-1-2-4-14(11)16/h1-10H,15H2
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10 -47.5n/an/an/an/an/a7.437



Universitat de Barcelona



Assay Description
Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...


Bioorg Med Chem 17: 7387-97 (2009)


Article DOI: 10.1016/j.bmc.2009.08.006
BindingDB Entry DOI: 10.7270/Q2RR1WKS
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM34154
PNG
(CHEMBL515307 | indenylsulfonamide, 15)
Show SMILES CN(C)CCC1=CCc2ccc(NS(=O)(=O)c3c(Cl)nc4sccn34)cc12
Show InChI InChI=1S/C18H19ClN4O2S2/c1-22(2)8-7-13-4-3-12-5-6-14(11-15(12)13)21-27(24,25)17-16(19)20-18-23(17)9-10-26-18/h4-6,9-11,21H,3,7-8H2,1-2H3
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10 -47.5n/an/an/an/an/a7.437



Universitat de Barcelona



Assay Description
Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...


Bioorg Med Chem 17: 7387-97 (2009)


Article DOI: 10.1016/j.bmc.2009.08.006
BindingDB Entry DOI: 10.7270/Q2RR1WKS
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM34146
PNG
(pyrrolidinylindole, (S)-5b)
Show SMILES CN1CCC[C@H]1Cc1c[nH]c2ccc(NS(=O)(=O)c3ccc(cc3)C(F)(F)F)cc12
Show InChI InChI=1S/C21H22F3N3O2S/c1-27-10-2-3-17(27)11-14-13-25-20-9-6-16(12-19(14)20)26-30(28,29)18-7-4-15(5-8-18)21(22,23)24/h4-9,12-13,17,25-26H,2-3,10-11H2,1H3/t17-/m0/s1
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10 -47.5n/an/a 21.6n/an/a7.437



Universitat de Barcelona



Assay Description
Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...


Bioorg Med Chem 17: 7387-97 (2009)


Article DOI: 10.1016/j.bmc.2009.08.006
BindingDB Entry DOI: 10.7270/Q2RR1WKS
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM21366
PNG
((2-{3-[(3-fluorobenzene)sulfonyl]-1H-indol-1-yl}et...)
Show SMILES CN(C)CCn1cc(c2ccccc12)S(=O)(=O)c1cccc(F)c1
Show InChI InChI=1S/C18H19FN2O2S/c1-20(2)10-11-21-13-18(16-8-3-4-9-17(16)21)24(22,23)15-7-5-6-14(19)12-15/h3-9,12-13H,10-11H2,1-2H3
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10.3 -45.1n/an/an/an/an/a7.422



Wyeth Research



Assay Description
IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...


J Med Chem 50: 5535-8 (2007)


Article DOI: 10.1021/jm070521y
BindingDB Entry DOI: 10.7270/Q23R0R5G
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM21343
PNG
(2-{1-[(2-bromobenzene)sulfonyl]-1H-indol-3-yl}etha...)
Show SMILES NCCc1cn(c2ccccc12)S(=O)(=O)c1ccccc1Br
Show InChI InChI=1S/C16H15BrN2O2S/c17-14-6-2-4-8-16(14)22(20,21)19-11-12(9-10-18)13-5-1-3-7-15(13)19/h1-8,11H,9-10,18H2
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11 -45.0n/an/a 148n/an/a7.422



Wyeth Research



Assay Description
IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...


J Med Chem 50: 5535-8 (2007)


Article DOI: 10.1021/jm070521y
BindingDB Entry DOI: 10.7270/Q23R0R5G
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM236526
PNG
(2-Ethoxy-10-[(2-N,N-dimethylamino-2-methyl)ethyl]b...)
Show SMILES CCOc1ccc2C3C(=C(CC(C)N(C)C)c2c1)c1ccccc1S3(=O)=O
Show InChI InChI=1S/C22H25NO3S/c1-5-26-15-10-11-16-18(13-15)19(12-14(2)23(3)4)21-17-8-6-7-9-20(17)27(24,25)22(16)21/h6-11,13-14,22H,5,12H2,1-4H3
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11.1 -47.2n/an/an/an/an/a7.437



Suven Life Sciences Ltd.



Assay Description
In brief, receptor source and radioligand used were human recombinant expressed in HEK-293 cells and [3H] LSD (60-80 Ci/mmol), respectively. The fina...


J Enzyme Inhib Med Chem 27: 443-50 (2012)


Article DOI: 10.3109/14756366.2011.595713
BindingDB Entry DOI: 10.7270/Q2HD7TJ5
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM236524
PNG
( 2-Methoxy-10-[(2-N,N-dimethylamino-2-methyl)ethyl...)
Show SMILES COc1ccc2C3C(=C(CC(C)N(C)C)c2c1)c1ccccc1S3(=O)=O
Show InChI InChI=1S/C21H23NO3S/c1-13(22(2)3)11-18-17-12-14(25-4)9-10-15(17)21-20(18)16-7-5-6-8-19(16)26(21,23)24/h5-10,12-13,21H,11H2,1-4H3
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11.6 -47.1n/an/an/an/an/a7.437



Suven Life Sciences Ltd.



Assay Description
In brief, receptor source and radioligand used were human recombinant expressed in HEK-293 cells and [3H] LSD (60-80 Ci/mmol), respectively. The fina...


J Enzyme Inhib Med Chem 27: 443-50 (2012)


Article DOI: 10.3109/14756366.2011.595713
BindingDB Entry DOI: 10.7270/Q2HD7TJ5
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM34150
PNG
(4-(3-methyl-1H-indole-1-sulfonyl)aniline, 8 | CHEM...)
Show SMILES Cc1cn(c2ccccc12)S(=O)(=O)c1ccc(N)cc1
Show InChI InChI=1S/C15H14N2O2S/c1-11-10-17(15-5-3-2-4-14(11)15)20(18,19)13-8-6-12(16)7-9-13/h2-10H,16H2,1H3
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12 -47.0n/an/a 320n/an/a7.437



Universitat de Barcelona



Assay Description
Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...


Bioorg Med Chem 17: 7387-97 (2009)


Article DOI: 10.1016/j.bmc.2009.08.006
BindingDB Entry DOI: 10.7270/Q2RR1WKS
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM34150
PNG
(4-(3-methyl-1H-indole-1-sulfonyl)aniline, 8 | CHEM...)
Show SMILES Cc1cn(c2ccccc12)S(=O)(=O)c1ccc(N)cc1
Show InChI InChI=1S/C15H14N2O2S/c1-11-10-17(15-5-3-2-4-14(11)15)20(18,19)13-8-6-12(16)7-9-13/h2-10H,16H2,1H3
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12n/an/an/an/an/an/a7.4n/a



Virginia Commonwealth University



Assay Description
The h5-HT6 radioligand binding assays were performed as previously described. In brief, h5-HT6 cDNA was transiently expressed in HEK-293 cells using...


Medicinal Chemistry Research 14: 1-18 (2005)


BindingDB Entry DOI: 10.7270/Q2NG4P78
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM21348
PNG
(2-{1-[(4-iodobenzene)sulfonyl]-1H-indol-3-yl}ethan...)
Show SMILES NCCc1cn(c2ccccc12)S(=O)(=O)c1ccc(I)cc1
Show InChI InChI=1S/C16H15IN2O2S/c17-13-5-7-14(8-6-13)22(20,21)19-11-12(9-10-18)15-3-1-2-4-16(15)19/h1-8,11H,9-10,18H2
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14 -44.4n/an/an/an/an/a7.422



Wyeth Research



Assay Description
IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...


J Med Chem 50: 5535-8 (2007)


Article DOI: 10.1021/jm070521y
BindingDB Entry DOI: 10.7270/Q23R0R5G
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM28578
PNG
(1-sulfonylindazole, 6g | N-[1-(naphthalene-1-sulfo...)
Show SMILES O=C(CCN1CCCCC1)Nc1ccc2cnn(c2c1)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C25H26N4O3S/c30-25(13-16-28-14-4-1-5-15-28)27-21-12-11-20-18-26-29(23(20)17-21)33(31,32)24-10-6-8-19-7-2-3-9-22(19)24/h2-3,6-12,17-18H,1,4-5,13-16H2,(H,27,30)
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15 -44.2n/an/an/an/an/a7.422



Wyeth Research



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...


Bioorg Med Chem Lett 19: 2413-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.071
BindingDB Entry DOI: 10.7270/Q28K77CF
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM21344
PNG
(2-{1-[(2-iodobenzene)sulfonyl]-1H-indol-3-yl}ethan...)
Show SMILES NCCc1cn(c2ccccc12)S(=O)(=O)c1ccccc1I
Show InChI InChI=1S/C16H15IN2O2S/c17-14-6-2-4-8-16(14)22(20,21)19-11-12(9-10-18)13-5-1-3-7-15(13)19/h1-8,11H,9-10,18H2
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16 -44.0n/an/an/an/an/a7.422



Wyeth Research



Assay Description
IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...


J Med Chem 50: 5535-8 (2007)


Article DOI: 10.1021/jm070521y
BindingDB Entry DOI: 10.7270/Q23R0R5G
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM34142
PNG
(2-ethyl-5-methoxy-N,N-dimethyltryptamine | CHEMBL2...)
Show SMILES CCc1[nH]c2ccc(OC)cc2c1CCN(C)C
Show InChI InChI=1S/C15H22N2O/c1-5-14-12(8-9-17(2)3)13-10-11(18-4)6-7-15(13)16-14/h6-7,10,16H,5,8-9H2,1-4H3
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16n/an/an/an/an/an/a7.4n/a



Virginia Commonwealth University



Assay Description
The h5-HT6 radioligand binding assays were performed as previously described. In brief, h5-HT6 cDNA was transiently expressed in HEK-293 cells using...


Medicinal Chemistry Research 14: 1-18 (2005)


BindingDB Entry DOI: 10.7270/Q2NG4P78
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM34142
PNG
(2-ethyl-5-methoxy-N,N-dimethyltryptamine | CHEMBL2...)
Show SMILES CCc1[nH]c2ccc(OC)cc2c1CCN(C)C
Show InChI InChI=1S/C15H22N2O/c1-5-14-12(8-9-17(2)3)13-10-11(18-4)6-7-15(13)16-14/h6-7,10,16H,5,8-9H2,1-4H3
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16 -46.3n/an/an/an/an/a7.437



Universitat de Barcelona



Assay Description
Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...


Bioorg Med Chem 17: 7387-97 (2009)


Article DOI: 10.1016/j.bmc.2009.08.006
BindingDB Entry DOI: 10.7270/Q2RR1WKS
More data for this
Ligand-Target Pair
5-Hydroxytryptamine receptor 6 (5-HT6)


(Homo sapiens (human))
BDBM34158
PNG
(indenylsulfonamide, 30)
Show SMILES CN1CCCC(C1)C1=C(C)Cc2ccc(NS(=O)(=O)c3c(Cl)nc4sccn34)cc12
Show InChI InChI=1S/C21H23ClN4O2S2/c1-13-10-14-5-6-16(11-17(14)18(13)15-4-3-7-25(2)12-15)24-30(27,28)20-19(22)23-21-26(20)8-9-29-21/h5-6,8-9,11,15,24H,3-4,7,10,12H2,1-2H3
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18 -46.0n/an/an/an/an/a7.437



Universitat de Barcelona



Assay Description
Radioligand binding assays were performed using membranes from HEK-293 transfected with human 5-HT6 receptor. In these membranes the receptor concent...


Bioorg Med Chem 17: 7387-97 (2009)


Article DOI: 10.1016/j.bmc.2009.08.006
BindingDB Entry DOI: 10.7270/Q2RR1WKS
More data for this
Ligand-Target Pair
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