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Compile Data Set for Download or QSAR

Found 459 hits of ph data with Target = '5-hydroxytryptamine receptor 1A'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM248048
PNG
(5-(1-(3-cyclopentenylbenzyl)piperidin-4-yl)-1H-ben...)
Show SMILES O=c1[nH]c2ccc(cc2[nH]1)C1CCN(Cc2cccc(c2)C2=CCCC2)CC1
Show InChI InChI=1S/C24H27N3O/c28-24-25-22-9-8-21(15-23(22)26-24)19-10-12-27(13-11-19)16-17-4-3-7-20(14-17)18-5-1-2-6-18/h3-5,7-9,14-15,19H,1-2,6,10-13,16H2,(H2,25,26,28)
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1.20 -53.0n/an/an/an/an/a7.437



King Fahd University of Petroleum & Minerals



Assay Description
Human-cloned 5-HT1A serotonin receptors stably expressed in HEK293-EBNA cells (Perkin-Elmer, Waltham, MA) were radiolabeled with 1.0nM [3H]-8-OH-DPAT...


J Enzyme Inhib Med Chem 29: 281-91 (2014)


Article DOI: 10.3109/14756366.2013.776556
BindingDB Entry DOI: 10.7270/Q2SN07WV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM248055
PNG
(5-(4-((5-cyclopentenylpyridin-3-yl)methyl)piperazi...)
Show SMILES O=c1[nH]c2ccc(cc2[nH]1)N1CCN(Cc2cncc(c2)C2=CCCC2)CC1
Show InChI InChI=1S/C22H25N5O/c28-22-24-20-6-5-19(12-21(20)25-22)27-9-7-26(8-10-27)15-16-11-18(14-23-13-16)17-3-1-2-4-17/h3,5-6,11-14H,1-2,4,7-10,15H2,(H2,24,25,28)
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1.70 -52.1n/an/an/an/an/a7.437



King Fahd University of Petroleum & Minerals



Assay Description
Human-cloned 5-HT1A serotonin receptors stably expressed in HEK293-EBNA cells (Perkin-Elmer, Waltham, MA) were radiolabeled with 1.0nM [3H]-8-OH-DPAT...


J Enzyme Inhib Med Chem 29: 281-91 (2014)


Article DOI: 10.3109/14756366.2013.776556
BindingDB Entry DOI: 10.7270/Q2SN07WV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM248054
PNG
(5-(4-(3-cyclopentenylbenzyl)piperazin-1-yl)-1H-ben...)
Show SMILES O=c1[nH]c2ccc(cc2[nH]1)N1CCN(Cc2cccc(c2)C2=CCCC2)CC1
Show InChI InChI=1S/C23H26N4O/c28-23-24-21-9-8-20(15-22(21)25-23)27-12-10-26(11-13-27)16-17-4-3-7-19(14-17)18-5-1-2-6-18/h3-5,7-9,14-15H,1-2,6,10-13,16H2,(H2,24,25,28)
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3.10 -50.5n/an/an/an/an/a7.437



King Fahd University of Petroleum & Minerals



Assay Description
Human-cloned 5-HT1A serotonin receptors stably expressed in HEK293-EBNA cells (Perkin-Elmer, Waltham, MA) were radiolabeled with 1.0nM [3H]-8-OH-DPAT...


J Enzyme Inhib Med Chem 29: 281-91 (2014)


Article DOI: 10.3109/14756366.2013.776556
BindingDB Entry DOI: 10.7270/Q2SN07WV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM248052
PNG
(5-(4-((5-phenylpyridin-3-yl)methyl)piperazin-1-yl)...)
Show SMILES O=c1[nH]c2ccc(cc2[nH]1)N1CCN(Cc2cncc(c2)-c2ccccc2)CC1
Show InChI InChI=1S/C23H23N5O/c29-23-25-21-7-6-20(13-22(21)26-23)28-10-8-27(9-11-28)16-17-12-19(15-24-14-17)18-4-2-1-3-5-18/h1-7,12-15H,8-11,16H2,(H2,25,26,29)
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5.30 -49.1n/an/an/an/an/a7.437



King Fahd University of Petroleum & Minerals



Assay Description
Human-cloned 5-HT1A serotonin receptors stably expressed in HEK293-EBNA cells (Perkin-Elmer, Waltham, MA) were radiolabeled with 1.0nM [3H]-8-OH-DPAT...


J Enzyme Inhib Med Chem 29: 281-91 (2014)


Article DOI: 10.3109/14756366.2013.776556
BindingDB Entry DOI: 10.7270/Q2SN07WV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM248049
PNG
(5-(1-((5-cyclopentenylpyridin-3-yl)methyl)piperidi...)
Show SMILES O=c1[nH]c2ccc(cc2[nH]1)C1CCN(Cc2cncc(c2)C2=CCCC2)CC1
Show InChI InChI=1S/C23H26N4O/c28-23-25-21-6-5-19(12-22(21)26-23)18-7-9-27(10-8-18)15-16-11-20(14-24-13-16)17-3-1-2-4-17/h3,5-6,11-14,18H,1-2,4,7-10,15H2,(H2,25,26,28)
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6.30 -48.7n/an/an/an/an/a7.437



King Fahd University of Petroleum & Minerals



Assay Description
Human-cloned 5-HT1A serotonin receptors stably expressed in HEK293-EBNA cells (Perkin-Elmer, Waltham, MA) were radiolabeled with 1.0nM [3H]-8-OH-DPAT...


J Enzyme Inhib Med Chem 29: 281-91 (2014)


Article DOI: 10.3109/14756366.2013.776556
BindingDB Entry DOI: 10.7270/Q2SN07WV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM248046
PNG
(5-(1-((5-phenylpyridin-3-yl)methyl)piperidin-4-yl)...)
Show SMILES O=c1[nH]c2ccc(cc2[nH]1)C1CCN(Cc2cncc(c2)-c2ccccc2)CC1
Show InChI InChI=1S/C24H24N4O/c29-24-26-22-7-6-20(13-23(22)27-24)19-8-10-28(11-9-19)16-17-12-21(15-25-14-17)18-4-2-1-3-5-18/h1-7,12-15,19H,8-11,16H2,(H2,26,27,29)
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6.72 -48.5n/an/an/an/an/a7.437



King Fahd University of Petroleum & Minerals



Assay Description
Human-cloned 5-HT1A serotonin receptors stably expressed in HEK293-EBNA cells (Perkin-Elmer, Waltham, MA) were radiolabeled with 1.0nM [3H]-8-OH-DPAT...


J Enzyme Inhib Med Chem 29: 281-91 (2014)


Article DOI: 10.3109/14756366.2013.776556
BindingDB Entry DOI: 10.7270/Q2SN07WV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM50241119
PNG
(7-(4-Biphenyl-3-ylmethyl-piperazin-1-yl)-3H-benzoo...)
Show SMILES O=c1[nH]c2cccc(N3CCN(Cc4cccc(c4)-c4ccccc4)CC3)c2o1
Show InChI InChI=1S/C24H23N3O2/c28-24-25-21-10-5-11-22(23(21)29-24)27-14-12-26(13-15-27)17-18-6-4-9-20(16-18)19-7-2-1-3-8-19/h1-11,16H,12-15,17H2,(H,25,28)
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7.19 -48.3n/an/an/an/an/a7.437



King Fahd University of Petroleum & Minerals



Assay Description
Human-cloned 5-HT1A serotonin receptors stably expressed in HEK293-EBNA cells (Perkin-Elmer, Waltham, MA) were radiolabeled with 1.0nM [3H]-8-OH-DPAT...


J Enzyme Inhib Med Chem 29: 281-91 (2014)


Article DOI: 10.3109/14756366.2013.776556
BindingDB Entry DOI: 10.7270/Q2SN07WV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM248056
PNG
(1-(2,3-dihydro-1,4-benzodioxin-5-yl)-4-[[5-(4-fluo...)
Show SMILES Fc1ccc(cc1)-c1cncc(CN2CCN(CC2)c2cccc3OCCOc23)c1
Show InChI InChI=1S/C24H24FN3O2/c25-21-6-4-19(5-7-21)20-14-18(15-26-16-20)17-27-8-10-28(11-9-27)22-2-1-3-23-24(22)30-13-12-29-23/h1-7,14-16H,8-13,17H2
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8.64 -47.9n/an/an/an/an/a7.437



King Fahd University of Petroleum & Minerals



Assay Description
Human-cloned 5-HT1A serotonin receptors stably expressed in HEK293-EBNA cells (Perkin-Elmer, Waltham, MA) were radiolabeled with 1.0nM [3H]-8-OH-DPAT...


J Enzyme Inhib Med Chem 29: 281-91 (2014)


Article DOI: 10.3109/14756366.2013.776556
BindingDB Entry DOI: 10.7270/Q2SN07WV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM248047
PNG
(5-(1-((5-(4-Fluorophenyl)pyridin-3-yl)methyl)piper...)
Show SMILES Fc1ccc(cc1)-c1cncc(CN2CCC(CC2)c2ccc3[nH]c(=O)[nH]c3c2)c1
Show InChI InChI=1S/C24H23FN4O/c25-21-4-1-17(2-5-21)20-11-16(13-26-14-20)15-29-9-7-18(8-10-29)19-3-6-22-23(12-19)28-24(30)27-22/h1-6,11-14,18H,7-10,15H2,(H2,27,28,30)
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9.42 -47.7n/an/an/an/an/a7.437



King Fahd University of Petroleum & Minerals



Assay Description
Human-cloned 5-HT1A serotonin receptors stably expressed in HEK293-EBNA cells (Perkin-Elmer, Waltham, MA) were radiolabeled with 1.0nM [3H]-8-OH-DPAT...


J Enzyme Inhib Med Chem 29: 281-91 (2014)


Article DOI: 10.3109/14756366.2013.776556
BindingDB Entry DOI: 10.7270/Q2SN07WV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM10755
PNG
(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Show SMILES NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
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10 -47.5n/an/an/an/an/a7.437



King Fahd University of Petroleum & Minerals



Assay Description
Human-cloned 5-HT1A serotonin receptors stably expressed in HEK293-EBNA cells (Perkin-Elmer, Waltham, MA) were radiolabeled with 1.0nM [3H]-8-OH-DPAT...


J Enzyme Inhib Med Chem 29: 281-91 (2014)


Article DOI: 10.3109/14756366.2013.776556
BindingDB Entry DOI: 10.7270/Q2SN07WV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM248053
PNG
(5-(4-((5-(4-fluorophenyl)pyridin-3-yl)methyl)piper...)
Show SMILES Fc1ccc(cc1)-c1cncc(CN2CCN(CC2)c2ccc3[nH]c(=O)[nH]c3c2)c1
Show InChI InChI=1S/C23H22FN5O/c24-19-3-1-17(2-4-19)18-11-16(13-25-14-18)15-28-7-9-29(10-8-28)20-5-6-21-22(12-20)27-23(30)26-21/h1-6,11-14H,7-10,15H2,(H2,26,27,30)
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11.4 -47.2n/an/an/an/an/a7.437



King Fahd University of Petroleum & Minerals



Assay Description
Human-cloned 5-HT1A serotonin receptors stably expressed in HEK293-EBNA cells (Perkin-Elmer, Waltham, MA) were radiolabeled with 1.0nM [3H]-8-OH-DPAT...


J Enzyme Inhib Med Chem 29: 281-91 (2014)


Article DOI: 10.3109/14756366.2013.776556
BindingDB Entry DOI: 10.7270/Q2SN07WV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM248045
PNG
(5-(1-((4'-Fluorobiphenyl-4-yl)methyl)piperidin...)
Show SMILES Fc1ccc(cc1)-c1ccc(CN2CCC(CC2)c2ccc3[nH]c(=O)[nH]c3c2)cc1
Show InChI InChI=1S/C25H24FN3O/c26-22-8-5-19(6-9-22)18-3-1-17(2-4-18)16-29-13-11-20(12-14-29)21-7-10-23-24(15-21)28-25(30)27-23/h1-10,15,20H,11-14,16H2,(H2,27,28,30)
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16.2 -46.3n/an/an/an/an/a7.437



King Fahd University of Petroleum & Minerals



Assay Description
Human-cloned 5-HT1A serotonin receptors stably expressed in HEK293-EBNA cells (Perkin-Elmer, Waltham, MA) were radiolabeled with 1.0nM [3H]-8-OH-DPAT...


J Enzyme Inhib Med Chem 29: 281-91 (2014)


Article DOI: 10.3109/14756366.2013.776556
BindingDB Entry DOI: 10.7270/Q2SN07WV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM248051
PNG
(5-(4-((4'-fluorobiphenyl-4-yl)methyl)piperazin...)
Show SMILES Fc1ccc(cc1)-c1ccc(CN2CCN(CC2)c2ccc3[nH]c(=O)[nH]c3c2)cc1
Show InChI InChI=1S/C24H23FN4O/c25-20-7-5-19(6-8-20)18-3-1-17(2-4-18)16-28-11-13-29(14-12-28)21-9-10-22-23(15-21)27-24(30)26-22/h1-10,15H,11-14,16H2,(H2,26,27,30)
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27.2 -44.9n/an/an/an/an/a7.437



King Fahd University of Petroleum & Minerals



Assay Description
Human-cloned 5-HT1A serotonin receptors stably expressed in HEK293-EBNA cells (Perkin-Elmer, Waltham, MA) were radiolabeled with 1.0nM [3H]-8-OH-DPAT...


J Enzyme Inhib Med Chem 29: 281-91 (2014)


Article DOI: 10.3109/14756366.2013.776556
BindingDB Entry DOI: 10.7270/Q2SN07WV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM248044
PNG
(5-(1-(biphenyl-4-ylmethyl)piperidin-4-yl)-1H-benzo...)
Show SMILES O=c1[nH]c2ccc(cc2[nH]1)C1CCN(Cc2ccc(cc2)-c2ccccc2)CC1
Show InChI InChI=1S/C25H25N3O/c29-25-26-23-11-10-22(16-24(23)27-25)21-12-14-28(15-13-21)17-18-6-8-20(9-7-18)19-4-2-1-3-5-19/h1-11,16,21H,12-15,17H2,(H2,26,27,29)
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34.2 -44.3n/an/an/an/an/a7.437



King Fahd University of Petroleum & Minerals



Assay Description
Human-cloned 5-HT1A serotonin receptors stably expressed in HEK293-EBNA cells (Perkin-Elmer, Waltham, MA) were radiolabeled with 1.0nM [3H]-8-OH-DPAT...


J Enzyme Inhib Med Chem 29: 281-91 (2014)


Article DOI: 10.3109/14756366.2013.776556
BindingDB Entry DOI: 10.7270/Q2SN07WV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM248050
PNG
(5-(4-(biphenyl-4-ylmethyl)piperazin-1-yl)-1H-benzo...)
Show SMILES O=c1[nH]c2ccc(cc2[nH]1)N1CCN(Cc2ccc(cc2)-c2ccccc2)CC1
Show InChI InChI=1S/C24H24N4O/c29-24-25-22-11-10-21(16-23(22)26-24)28-14-12-27(13-15-28)17-18-6-8-20(9-7-18)19-4-2-1-3-5-19/h1-11,16H,12-15,17H2,(H2,25,26,29)
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46.3 -43.5n/an/an/an/an/a7.437



King Fahd University of Petroleum & Minerals



Assay Description
Human-cloned 5-HT1A serotonin receptors stably expressed in HEK293-EBNA cells (Perkin-Elmer, Waltham, MA) were radiolabeled with 1.0nM [3H]-8-OH-DPAT...


J Enzyme Inhib Med Chem 29: 281-91 (2014)


Article DOI: 10.3109/14756366.2013.776556
BindingDB Entry DOI: 10.7270/Q2SN07WV
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM28580
PNG
(1-sulfonylindazole, 7b | N-[1-(naphthalene-1-sulfo...)
Show SMILES O=C(Nc1ccc2cnn(c2c1)S(=O)(=O)c1cccc2ccccc12)C1CCCNC1
Show InChI InChI=1S/C23H22N4O3S/c28-23(18-7-4-12-24-14-18)26-19-11-10-17-15-25-27(21(17)13-19)31(29,30)22-9-3-6-16-5-1-2-8-20(16)22/h1-3,5-6,8-11,13,15,18,24H,4,7,12,14H2,(H,26,28)
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5.60E+3 -29.7n/an/an/an/an/a7.422



Wyeth Research



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...


Bioorg Med Chem Lett 19: 2413-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.071
BindingDB Entry DOI: 10.7270/Q28K77CF
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM28574
PNG
(1-sulfonylindazole, 6c | 3-amino-N-[1-(naphthalene...)
Show SMILES NCCC(=O)Nc1ccc2cnn(c2c1)S(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C20H18N4O3S/c21-11-10-20(25)23-16-9-8-15-13-22-24(18(15)12-16)28(26,27)19-7-3-5-14-4-1-2-6-17(14)19/h1-9,12-13H,10-11,21H2,(H,23,25)
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6.40E+3 -29.3n/an/an/an/an/a7.422



Wyeth Research



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...


Bioorg Med Chem Lett 19: 2413-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.071
BindingDB Entry DOI: 10.7270/Q28K77CF
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM28579
PNG
(1-sulfonylindazole, 7a | N-[1-(naphthalene-1-sulfo...)
Show SMILES O=C(Nc1ccc2cnn(c2c1)S(=O)(=O)c1cccc2ccccc12)C1CCNCC1
Show InChI InChI=1S/C23H22N4O3S/c28-23(17-10-12-24-13-11-17)26-19-9-8-18-15-25-27(21(18)14-19)31(29,30)22-7-3-5-16-4-1-2-6-20(16)22/h1-9,14-15,17,24H,10-13H2,(H,26,28)
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8.50E+3 -28.7n/an/an/an/an/a7.422



Wyeth Research



Assay Description
Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...


Bioorg Med Chem Lett 19: 2413-5 (2009)


Article DOI: 10.1016/j.bmcl.2009.03.071
BindingDB Entry DOI: 10.7270/Q28K77CF
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM30873
PNG
(2-(4-pyridyl)-5-[[2-(4-pyridyl)-1,3-benzoxazol-5-y...)
Show SMILES O=S(=O)(c1ccc2oc(nc2c1)-c1ccncc1)c1ccc2oc(nc2c1)-c1ccncc1
Show InChI InChI=1S/C24H14N4O4S/c29-33(30,17-1-3-21-19(13-17)27-23(31-21)15-5-9-25-10-6-15)18-2-4-22-20(14-18)28-24(32-22)16-7-11-26-12-8-16/h1-14H
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n/an/an/an/a 9.90E+4n/an/a7.423



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
A cell line containing the human 5-HT1a receptor, the promiscuous G-alpha-15 protein (Ga15) as well as the beta-lactamase (BLA) reporter-gene under c...


PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q21N7ZG0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM30874
PNG
(MLS000091318 | N-[2-(3,4-diethoxyphenyl)ethyl]-2-[...)
Show SMILES CCOc1ccc(CCNC(=O)CN2CCN(Cc3ccccc3C)C2=O)cc1OCC
Show InChI InChI=1S/C25H33N3O4/c1-4-31-22-11-10-20(16-23(22)32-5-2)12-13-26-24(29)18-28-15-14-27(25(28)30)17-21-9-7-6-8-19(21)3/h6-11,16H,4-5,12-15,17-18H2,1-3H3,(H,26,29)
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n/an/an/an/a 9.90E+4n/an/a7.423



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
A cell line containing the human 5-HT1a receptor, the promiscuous G-alpha-15 protein (Ga15) as well as the beta-lactamase (BLA) reporter-gene under c...


PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q21N7ZG0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM30875
PNG
(MLS000043125 | N-(4-{[(2Z)-2-({[4-(acetylamino)phe...)
Show SMILES CC(=O)Nc1ccc(cc1)S(=O)(=O)N=C1SCCN1S(=O)(=O)c1ccc(NC(C)=O)cc1
Show InChI InChI=1S/C19H20N4O6S3/c1-13(24)20-15-3-7-17(8-4-15)31(26,27)22-19-23(11-12-30-19)32(28,29)18-9-5-16(6-10-18)21-14(2)25/h3-10H,11-12H2,1-2H3,(H,20,24)(H,21,25)
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n/an/an/an/a 9.90E+4n/an/a7.423



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
A cell line containing the human 5-HT1a receptor, the promiscuous G-alpha-15 protein (Ga15) as well as the beta-lactamase (BLA) reporter-gene under c...


PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q21N7ZG0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM30876
PNG
(4-[[3-[(4-chlorophenyl)sulfonylamino]-3-(2-furanyl...)
Show SMILES CCOC(=O)N1CCC(CC1)NC(=O)CC(NS(=O)(=O)c1ccc(Cl)cc1)c1ccco1
Show InChI InChI=1S/C21H26ClN3O6S/c1-2-30-21(27)25-11-9-16(10-12-25)23-20(26)14-18(19-4-3-13-31-19)24-32(28,29)17-7-5-15(22)6-8-17/h3-8,13,16,18,24H,2,9-12,14H2,1H3,(H,23,26)
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n/an/an/an/a 9.90E+4n/an/a7.423



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
A cell line containing the human 5-HT1a receptor, the promiscuous G-alpha-15 protein (Ga15) as well as the beta-lactamase (BLA) reporter-gene under c...


PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q21N7ZG0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM30870
PNG
(4-(3-methoxyphenyl)-2-(1-piperidinyl)-6-(trifluoro...)
Show SMILES COc1cccc(c1)-c1cc(nc(n1)N1CCCCC1)C(F)(F)F
Show InChI InChI=1S/C17H18F3N3O/c1-24-13-7-5-6-12(10-13)14-11-15(17(18,19)20)22-16(21-14)23-8-3-2-4-9-23/h5-7,10-11H,2-4,8-9H2,1H3
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n/an/an/an/a 9.90E+4n/an/a7.423



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
A cell line containing the human 5-HT1a receptor, the promiscuous G-alpha-15 protein (Ga15) as well as the beta-lactamase (BLA) reporter-gene under c...


PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q21N7ZG0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM30871
PNG
(1,4-dioxa-8-azaspiro[4.5]decan-8-yl-[2-methyl-1-(3...)
Show SMILES Cc1nc2cc(ccc2n1-c1cccc(C)c1)C(=O)N1CCC2(CC1)OCCO2
Show InChI InChI=1S/C23H25N3O3/c1-16-4-3-5-19(14-16)26-17(2)24-20-15-18(6-7-21(20)26)22(27)25-10-8-23(9-11-25)28-12-13-29-23/h3-7,14-15H,8-13H2,1-2H3
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n/an/an/an/a 9.90E+4n/an/a7.423



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
A cell line containing the human 5-HT1a receptor, the promiscuous G-alpha-15 protein (Ga15) as well as the beta-lactamase (BLA) reporter-gene under c...


PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q21N7ZG0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM30872
PNG
(3-keto-2-(2-methoxyethyl)-N-piperonyl-isoindoline-...)
Show SMILES COCCN1Cc2cccc(C(=O)NCc3ccc4OCOc4c3)c2C1=O
Show InChI InChI=1S/C20H20N2O5/c1-25-8-7-22-11-14-3-2-4-15(18(14)20(22)24)19(23)21-10-13-5-6-16-17(9-13)27-12-26-16/h2-6,9H,7-8,10-12H2,1H3,(H,21,23)
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n/an/an/an/a 9.90E+4n/an/a7.423



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
A cell line containing the human 5-HT1a receptor, the promiscuous G-alpha-15 protein (Ga15) as well as the beta-lactamase (BLA) reporter-gene under c...


PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q21N7ZG0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM30877
PNG
(1-[[2-(3-chlorophenyl)-5-methyl-1,3-oxazol-4-yl]me...)
Show SMILES Cc1oc(nc1CN1CCCC(C1)C(=O)NCCCN1CCOCC1)-c1cccc(Cl)c1
Show InChI InChI=1S/C24H33ClN4O3/c1-18-22(27-24(32-18)19-5-2-7-21(25)15-19)17-29-9-3-6-20(16-29)23(30)26-8-4-10-28-11-13-31-14-12-28/h2,5,7,15,20H,3-4,6,8-14,16-17H2,1H3,(H,26,30)
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n/an/an/an/a 9.90E+4n/an/a7.423



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
A cell line containing the human 5-HT1a receptor, the promiscuous G-alpha-15 protein (Ga15) as well as the beta-lactamase (BLA) reporter-gene under c...


PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q21N7ZG0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM30878
PNG
((2Z)-2-(benzylimino)-7-hydroxy-2H-chromene-3-carbo...)
Show SMILES NC(=O)c1cc2ccc(=O)cc2oc1NCc1ccccc1
Show InChI InChI=1S/C17H14N2O3/c18-16(21)14-8-12-6-7-13(20)9-15(12)22-17(14)19-10-11-4-2-1-3-5-11/h1-9,19H,10H2,(H2,18,21)
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n/an/an/an/a 1.73E+4n/an/a7.423



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
A cell line containing the human 5-HT1a receptor, the promiscuous G-alpha-15 protein (Ga15) as well as the beta-lactamase (BLA) reporter-gene under c...


PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q21N7ZG0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM30879
PNG
(1-({1-[(5-bromothien-2-yl)sulfonyl]piperidin-3-yl}...)
Show SMILES Brc1ccc(s1)S(=O)(=O)N1CCCC(C1)C(=O)N1CCCCCC1
Show InChI InChI=1S/C16H23BrN2O3S2/c17-14-7-8-15(23-14)24(21,22)19-11-5-6-13(12-19)16(20)18-9-3-1-2-4-10-18/h7-8,13H,1-6,9-12H2
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n/an/an/an/a 9.90E+4n/an/a7.423



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
A cell line containing the human 5-HT1a receptor, the promiscuous G-alpha-15 protein (Ga15) as well as the beta-lactamase (BLA) reporter-gene under c...


PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q21N7ZG0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM30880
PNG
(2-thiophenecarboxylic acid [4-(benzenesulfonyl)-5-...)
Show SMILES Cc1nn(c(OC(=O)c2cccs2)c1S(=O)(=O)c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C21H16N2O4S2/c1-15-19(29(25,26)17-11-6-3-7-12-17)20(27-21(24)18-13-8-14-28-18)23(22-15)16-9-4-2-5-10-16/h2-14H,1H3
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n/an/an/an/a 9.90E+4n/an/a7.423



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
A cell line containing the human 5-HT1a receptor, the promiscuous G-alpha-15 protein (Ga15) as well as the beta-lactamase (BLA) reporter-gene under c...


PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q21N7ZG0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM30881
PNG
(5-tert-butyl-N-[1-(2-methylbenzyl)-1H-pyrazol-4-yl...)
Show SMILES Cc1ccccc1Cn1cc(NC(=O)c2noc3CCC(Cc23)C(C)(C)C)cn1
Show InChI InChI=1S/C23H28N4O2/c1-15-7-5-6-8-16(15)13-27-14-18(12-24-27)25-22(28)21-19-11-17(23(2,3)4)9-10-20(19)29-26-21/h5-8,12,14,17H,9-11,13H2,1-4H3,(H,25,28)
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n/an/an/an/a 9.90E+4n/an/a7.423



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
A cell line containing the human 5-HT1a receptor, the promiscuous G-alpha-15 protein (Ga15) as well as the beta-lactamase (BLA) reporter-gene under c...


PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q21N7ZG0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM30882
PNG
(3-(2-methylpropoxycarbonylamino)propyl N-phenylcar...)
Show SMILES CC(C)COC(=O)NCCCOC(=O)Nc1ccccc1
Show InChI InChI=1S/C15H22N2O4/c1-12(2)11-21-14(18)16-9-6-10-20-15(19)17-13-7-4-3-5-8-13/h3-5,7-8,12H,6,9-11H2,1-2H3,(H,16,18)(H,17,19)
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n/an/an/an/a 9.90E+4n/an/a7.423



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
A cell line containing the human 5-HT1a receptor, the promiscuous G-alpha-15 protein (Ga15) as well as the beta-lactamase (BLA) reporter-gene under c...


PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q21N7ZG0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM30883
PNG
(4-(4-methylphenyl)-3-(3-pyridinyl)-1H-1,2,4-triazo...)
Show SMILES Cc1ccc(cc1)-n1c(n[nH]c1=S)-c1cccnc1
Show InChI InChI=1S/C14H12N4S/c1-10-4-6-12(7-5-10)18-13(16-17-14(18)19)11-3-2-8-15-9-11/h2-9H,1H3,(H,17,19)
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n/an/an/an/a 9.90E+4n/an/a7.423



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
A cell line containing the human 5-HT1a receptor, the promiscuous G-alpha-15 protein (Ga15) as well as the beta-lactamase (BLA) reporter-gene under c...


PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q21N7ZG0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM30884
PNG
(1-(3-methylphenyl)-5-(piperidin-1-ylcarbonyl)-1H-b...)
Show SMILES Cc1cccc(c1)-n1cnc2cc(ccc12)C(=O)N1CCCCC1
Show InChI InChI=1S/C20H21N3O/c1-15-6-5-7-17(12-15)23-14-21-18-13-16(8-9-19(18)23)20(24)22-10-3-2-4-11-22/h5-9,12-14H,2-4,10-11H2,1H3
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n/an/an/an/a 5.81E+4n/an/a7.423



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
A cell line containing the human 5-HT1a receptor, the promiscuous G-alpha-15 protein (Ga15) as well as the beta-lactamase (BLA) reporter-gene under c...


PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q21N7ZG0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM30885
PNG
(4-[3-(2,6-dimethoxyphenoxy)-2-hydroxy-propyl]piper...)
Show SMILES CCOC(=O)N1CCN(CC(O)COc2c(OC)cccc2OC)CC1
Show InChI InChI=1S/C18H28N2O6/c1-4-25-18(22)20-10-8-19(9-11-20)12-14(21)13-26-17-15(23-2)6-5-7-16(17)24-3/h5-7,14,21H,4,8-13H2,1-3H3
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n/an/an/an/a 9.90E+4n/an/a7.423



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
A cell line containing the human 5-HT1a receptor, the promiscuous G-alpha-15 protein (Ga15) as well as the beta-lactamase (BLA) reporter-gene under c...


PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q21N7ZG0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM30886
PNG
(3-(2-keto-1,3-benzothiazol-3-yl)-N-(2-thenyl)propi...)
Show SMILES O=C(CCn1c2ccccc2sc1=O)NCc1cccs1
Show InChI InChI=1S/C15H14N2O2S2/c18-14(16-10-11-4-3-9-20-11)7-8-17-12-5-1-2-6-13(12)21-15(17)19/h1-6,9H,7-8,10H2,(H,16,18)
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n/an/an/an/a 9.90E+4n/an/a7.423



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
A cell line containing the human 5-HT1a receptor, the promiscuous G-alpha-15 protein (Ga15) as well as the beta-lactamase (BLA) reporter-gene under c...


PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q21N7ZG0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM30887
PNG
(2-[(4-keto-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimi...)
Show SMILES COC(=O)C(C)Sc1nc2CCSc2c(=O)n1-c1ccccc1
Show InChI InChI=1S/C16H16N2O3S2/c1-10(15(20)21-2)23-16-17-12-8-9-22-13(12)14(19)18(16)11-6-4-3-5-7-11/h3-7,10H,8-9H2,1-2H3
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n/an/an/an/a 9.90E+4n/an/a7.423



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
A cell line containing the human 5-HT1a receptor, the promiscuous G-alpha-15 protein (Ga15) as well as the beta-lactamase (BLA) reporter-gene under c...


PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q21N7ZG0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM30888
PNG
(MLS000090995 | N-[2-(2-keto-6,7-dimethyl-1H-quinol...)
Show SMILES CCC(=O)NCCc1cc2cc(C)c(C)cc2[nH]c1=O
Show InChI InChI=1S/C16H20N2O2/c1-4-15(19)17-6-5-12-9-13-7-10(2)11(3)8-14(13)18-16(12)20/h7-9H,4-6H2,1-3H3,(H,17,19)(H,18,20)
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n/an/an/an/a 9.90E+4n/an/a7.423



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
A cell line containing the human 5-HT1a receptor, the promiscuous G-alpha-15 protein (Ga15) as well as the beta-lactamase (BLA) reporter-gene under c...


PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q21N7ZG0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM30889
PNG
((2Z)-7-hydroxy-2-[(3-methylphenyl)imino]-2H-chrome...)
Show SMILES Cc1cccc(Nc2oc3cc(=O)ccc3cc2C(N)=O)c1
Show InChI InChI=1S/C17H14N2O3/c1-10-3-2-4-12(7-10)19-17-14(16(18)21)8-11-5-6-13(20)9-15(11)22-17/h2-9,19H,1H3,(H2,18,21)
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n/an/an/an/a 3.07E+4n/an/a7.423



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
A cell line containing the human 5-HT1a receptor, the promiscuous G-alpha-15 protein (Ga15) as well as the beta-lactamase (BLA) reporter-gene under c...


PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q21N7ZG0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM30890
PNG
(4,4'-(2,2-propanediyl)bis{2,6-bis[(dimethylami...)
Show SMILES CN(C)Cc1cc(cc(CN(C)C)c1O)C(C)(C)c1cc(CN(C)C)c(O)c(CN(C)C)c1
Show InChI InChI=1S/C27H44N4O2/c1-27(2,23-11-19(15-28(3)4)25(32)20(12-23)16-29(5)6)24-13-21(17-30(7)8)26(33)22(14-24)18-31(9)10/h11-14,32-33H,15-18H2,1-10H3
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n/an/an/an/a 9.90E+4n/an/a7.423



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
A cell line containing the human 5-HT1a receptor, the promiscuous G-alpha-15 protein (Ga15) as well as the beta-lactamase (BLA) reporter-gene under c...


PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q21N7ZG0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM30891
PNG
(MLS000049147 | N-(2-furanylmethyl)-7-hydroxy-2-oxo...)
Show SMILES Oc1ccc2cc(C(=O)NCc3ccco3)c(=O)oc2c1
Show InChI InChI=1S/C15H11NO5/c17-10-4-3-9-6-12(15(19)21-13(9)7-10)14(18)16-8-11-2-1-5-20-11/h1-7,17H,8H2,(H,16,18)
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n/an/an/an/a 5.90E+3n/an/a7.423



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
A cell line containing the human 5-HT1a receptor, the promiscuous G-alpha-15 protein (Ga15) as well as the beta-lactamase (BLA) reporter-gene under c...


PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q21N7ZG0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM30892
PNG
(1-(2,3-dihydroindol-1-yl)-2-ethoxy-ethanone | 1-(2...)
Show SMILES CCOCC(=O)N1CCc2ccccc12
Show InChI InChI=1S/C12H15NO2/c1-2-15-9-12(14)13-8-7-10-5-3-4-6-11(10)13/h3-6H,2,7-9H2,1H3
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n/an/an/an/a 9.90E+4n/an/a7.423



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
A cell line containing the human 5-HT1a receptor, the promiscuous G-alpha-15 protein (Ga15) as well as the beta-lactamase (BLA) reporter-gene under c...


PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q21N7ZG0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM30893
PNG
(1-[2-[2-chloro-4-(isopropylsulfamoyl)phenoxy]acety...)
Show SMILES CCOC(=O)C1CCN(CC1)C(=O)COc1ccc(cc1Cl)S(=O)(=O)NC(C)C
Show InChI InChI=1S/C19H27ClN2O6S/c1-4-27-19(24)14-7-9-22(10-8-14)18(23)12-28-17-6-5-15(11-16(17)20)29(25,26)21-13(2)3/h5-6,11,13-14,21H,4,7-10,12H2,1-3H3
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n/an/an/an/a 9.90E+4n/an/a7.423



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
A cell line containing the human 5-HT1a receptor, the promiscuous G-alpha-15 protein (Ga15) as well as the beta-lactamase (BLA) reporter-gene under c...


PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q21N7ZG0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM30894
PNG
(1-[4-[4-(1,3-benzodioxol-5-ylmethylamino)phenyl]-1...)
Show SMILES CC(=O)N1CCN(CC1)c1ccc(NCc2ccc3OCOc3c2)cc1
Show InChI InChI=1S/C20H23N3O3/c1-15(24)22-8-10-23(11-9-22)18-5-3-17(4-6-18)21-13-16-2-7-19-20(12-16)26-14-25-19/h2-7,12,21H,8-11,13-14H2,1H3
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n/an/an/an/a 9.90E+4n/an/a7.423



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
A cell line containing the human 5-HT1a receptor, the promiscuous G-alpha-15 protein (Ga15) as well as the beta-lactamase (BLA) reporter-gene under c...


PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q21N7ZG0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM30895
PNG
(2-(2-cyanoethylsulfanyl)-6-(5-methylfuran-2-yl)-4-...)
Show SMILES Cc1ccc(o1)-c1cc(c(C#N)c(SCCC#N)n1)C(F)(F)F
Show InChI InChI=1S/C15H10F3N3OS/c1-9-3-4-13(22-9)12-7-11(15(16,17)18)10(8-20)14(21-12)23-6-2-5-19/h3-4,7H,2,6H2,1H3
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n/an/an/an/a 9.90E+4n/an/a7.423



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
A cell line containing the human 5-HT1a receptor, the promiscuous G-alpha-15 protein (Ga15) as well as the beta-lactamase (BLA) reporter-gene under c...


PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q21N7ZG0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM30896
PNG
(2-[cyclohexyl-(4-fluorophenyl)sulfonyl-amino]-N-me...)
Show SMILES CNC(=O)CN(C1CCCCC1)S(=O)(=O)c1ccc(F)cc1
Show InChI InChI=1S/C15H21FN2O3S/c1-17-15(19)11-18(13-5-3-2-4-6-13)22(20,21)14-9-7-12(16)8-10-14/h7-10,13H,2-6,11H2,1H3,(H,17,19)
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n/an/an/an/a 9.90E+4n/an/a7.423



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
A cell line containing the human 5-HT1a receptor, the promiscuous G-alpha-15 protein (Ga15) as well as the beta-lactamase (BLA) reporter-gene under c...


PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q21N7ZG0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM30897
PNG
(MLS000050596 | N-({5-[(2-{[2-chloro-5-(trifluorome...)
Show SMILES CCn1c(CNC(=O)c2ccco2)nnc1SCC(=O)Nc1cc(ccc1Cl)C(F)(F)F
Show InChI InChI=1S/C19H17ClF3N5O3S/c1-2-28-15(9-24-17(30)14-4-3-7-31-14)26-27-18(28)32-10-16(29)25-13-8-11(19(21,22)23)5-6-12(13)20/h3-8H,2,9-10H2,1H3,(H,24,30)(H,25,29)
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n/an/an/an/a 9.90E+4n/an/a7.423



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
A cell line containing the human 5-HT1a receptor, the promiscuous G-alpha-15 protein (Ga15) as well as the beta-lactamase (BLA) reporter-gene under c...


PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q21N7ZG0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM30898
PNG
(4-(4-piperonylpiperazino)benzofuro[3,2-d]pyrimidin...)
Show SMILES C(N1CCN(CC1)c1ncnc2c3ccccc3oc12)c1ccc2OCOc2c1
Show InChI InChI=1S/C22H20N4O3/c1-2-4-17-16(3-1)20-21(29-17)22(24-13-23-20)26-9-7-25(8-10-26)12-15-5-6-18-19(11-15)28-14-27-18/h1-6,11,13H,7-10,12,14H2
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n/an/an/an/a 9.90E+4n/an/a7.423



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
A cell line containing the human 5-HT1a receptor, the promiscuous G-alpha-15 protein (Ga15) as well as the beta-lactamase (BLA) reporter-gene under c...


PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q21N7ZG0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM30899
PNG
(5-ethoxy-2,4-dimethyl-N-(2-pyridinylmethyl)benzene...)
Show SMILES CCOc1cc(c(C)cc1C)S(=O)(=O)NCc1ccccn1
Show InChI InChI=1S/C16H20N2O3S/c1-4-21-15-10-16(13(3)9-12(15)2)22(19,20)18-11-14-7-5-6-8-17-14/h5-10,18H,4,11H2,1-3H3
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n/an/an/an/a 9.90E+4n/an/a7.423



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
A cell line containing the human 5-HT1a receptor, the promiscuous G-alpha-15 protein (Ga15) as well as the beta-lactamase (BLA) reporter-gene under c...


PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q21N7ZG0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM30900
PNG
(1-(1-phenyl-4-pyrazolo[3,4-d]pyrimidinyl)-4-piperi...)
Show SMILES CCOC(=O)C1CCN(CC1)c1ncnc2n(ncc12)-c1ccccc1
Show InChI InChI=1S/C19H21N5O2/c1-2-26-19(25)14-8-10-23(11-9-14)17-16-12-22-24(18(16)21-13-20-17)15-6-4-3-5-7-15/h3-7,12-14H,2,8-11H2,1H3
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n/an/an/an/a 9.90E+4n/an/a7.423



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
A cell line containing the human 5-HT1a receptor, the promiscuous G-alpha-15 protein (Ga15) as well as the beta-lactamase (BLA) reporter-gene under c...


PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q21N7ZG0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Homo sapiens (human))
BDBM30901
PNG
(10-methyl-15-oxo-6,21-dioxa-14-azahexacyclo[16.2.1...)
Show SMILES Cc1ccc2N3C(C4CCOC4c2c1)C12OC(C=C1)C(C2C3=O)C(O)=O
Show InChI InChI=1S/C20H19NO5/c1-9-2-3-12-11(8-9)16-10(5-7-25-16)17-20-6-4-13(26-20)14(19(23)24)15(20)18(22)21(12)17/h2-4,6,8,10,13-17H,5,7H2,1H3,(H,23,24)
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n/an/an/an/a 9.90E+4n/an/a7.423



The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay


Assay Description
A cell line containing the human 5-HT1a receptor, the promiscuous G-alpha-15 protein (Ga15) as well as the beta-lactamase (BLA) reporter-gene under c...


PubChem Bioassay (2007)


BindingDB Entry DOI: 10.7270/Q21N7ZG0
More data for this
Ligand-Target Pair
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