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Compile Data Set for Download or QSAR

Found 31 hits of ph data with Target = '5-hydroxytryptamine receptor 2A'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM35927
PNG
(3-(9,10-dihydroanthracen-9-yl)-N-methylpropan-1-am...)
Show SMILES CNCCCC1c2ccccc2Cc2ccccc12
Show InChI InChI=1S/C18H21N/c1-19-12-6-11-18-16-9-4-2-7-14(16)13-15-8-3-5-10-17(15)18/h2-5,7-10,18-19H,6,11-13H2,1H3
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Article
PubMed
13 -44.7n/an/an/an/an/a7.423



Virginia Commonwealth University



Assay Description
Aliquots of radioligand are dispensed into the wells of 96-well plates. Then, duplicate aliquots of the test and reference compound dilutions are add...


Bioorg Med Chem 17: 6496-504 (2009)


Article DOI: 10.1016/j.bmc.2009.08.016
BindingDB Entry DOI: 10.7270/Q2QJ7FN6
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM35920
PNG
(9,10-dihydroanthracene(DHA), 1a | 9-(Aminomethyl)-...)
Show SMILES NCC1c2ccccc2Cc2ccccc12
Show InChI InChI=1S/C15H15N/c16-10-15-13-7-3-1-5-11(13)9-12-6-2-4-8-14(12)15/h1-8,15H,9-10,16H2
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PubMed
20 -43.6n/an/an/an/an/a7.423



Virginia Commonwealth University



Assay Description
Aliquots of radioligand are dispensed into the wells of 96-well plates. Then, duplicate aliquots of the test and reference compound dilutions are add...


Bioorg Med Chem 17: 6496-504 (2009)


Article DOI: 10.1016/j.bmc.2009.08.016
BindingDB Entry DOI: 10.7270/Q2QJ7FN6
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM35928
PNG
(3-(9,10-dihydroanthracen-9-yl)-N,N-dimethylpropan-...)
Show SMILES CN(C)CCCC1c2ccccc2Cc2ccccc12
Show InChI InChI=1S/C19H23N/c1-20(2)13-7-12-19-17-10-5-3-8-15(17)14-16-9-4-6-11-18(16)19/h3-6,8-11,19H,7,12-14H2,1-2H3
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22 -43.4n/an/an/an/an/a7.423



Virginia Commonwealth University



Assay Description
Aliquots of radioligand are dispensed into the wells of 96-well plates. Then, duplicate aliquots of the test and reference compound dilutions are add...


Bioorg Med Chem 17: 6496-504 (2009)


Article DOI: 10.1016/j.bmc.2009.08.016
BindingDB Entry DOI: 10.7270/Q2QJ7FN6
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM35926
PNG
(3-(9,10-Dihydro-anthracen-9-yl)-propylamine | 9,10...)
Show SMILES NCCCC1c2ccccc2Cc2ccccc12
Show InChI InChI=1S/C17H19N/c18-11-5-10-17-15-8-3-1-6-13(15)12-14-7-2-4-9-16(14)17/h1-4,6-9,17H,5,10-12,18H2
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32 -42.5n/an/an/an/an/a7.423



Virginia Commonwealth University



Assay Description
Aliquots of radioligand are dispensed into the wells of 96-well plates. Then, duplicate aliquots of the test and reference compound dilutions are add...


Bioorg Med Chem 17: 6496-504 (2009)


Article DOI: 10.1016/j.bmc.2009.08.016
BindingDB Entry DOI: 10.7270/Q2QJ7FN6
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM35921
PNG
((9,10-Dihydro-anthracen-9-ylmethyl)-methyl-amine |...)
Show SMILES CNCC1c2ccccc2Cc2ccccc12
Show InChI InChI=1S/C16H17N/c1-17-11-16-14-8-4-2-6-12(14)10-13-7-3-5-9-15(13)16/h2-9,16-17H,10-11H2,1H3
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PubMed
52 -41.3n/an/an/an/an/a7.423



Virginia Commonwealth University



Assay Description
Aliquots of radioligand are dispensed into the wells of 96-well plates. Then, duplicate aliquots of the test and reference compound dilutions are add...


Bioorg Med Chem 17: 6496-504 (2009)


Article DOI: 10.1016/j.bmc.2009.08.016
BindingDB Entry DOI: 10.7270/Q2QJ7FN6
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM82183
PNG
((E)-[2-(dimethylamino)ethoxy]({[3-(2-fluoroethoxy)...)
Show SMILES COc1c(OCCF)cccc1\C(=N\OCCN(C)C)C1CCN(CCc2ccc(F)cc2)CC1
Show InChI InChI=1S/C27H37F2N3O3/c1-31(2)18-20-35-30-26(24-5-4-6-25(27(24)33-3)34-19-14-28)22-12-16-32(17-13-22)15-11-21-7-9-23(29)10-8-21/h4-10,22H,11-20H2,1-3H3/b30-26+
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57 -43.0n/an/an/an/an/a7.437



University of Mainz



Assay Description
5-HT-2A receptor affinity was determined by a radioligand competition binding assay with GF-62 cells, a clonal cell line expressing high amounts of 5...


Chem Biol Drug Des 76: 361-6 (2010)


Article DOI: 10.1111/j.1747-0285.2010.01011.x
BindingDB Entry DOI: 10.7270/Q2TX3CV8
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM35925
PNG
(9,10-dihydroanthracene(DHA), 2c)
Show SMILES CN(C)CCC1c2ccccc2Cc2ccccc12
Show InChI InChI=1S/C18H21N/c1-19(2)12-11-18-16-9-5-3-7-14(16)13-15-8-4-6-10-17(15)18/h3-10,18H,11-13H2,1-2H3
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84 -40.1n/an/an/an/an/a7.423



Virginia Commonwealth University



Assay Description
Aliquots of radioligand are dispensed into the wells of 96-well plates. Then, duplicate aliquots of the test and reference compound dilutions are add...


Bioorg Med Chem 17: 6496-504 (2009)


Article DOI: 10.1016/j.bmc.2009.08.016
BindingDB Entry DOI: 10.7270/Q2QJ7FN6
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM35924
PNG
(9,10-dihydroanthracene(DHA), 2b)
Show SMILES CNCCC1c2ccccc2Cc2ccccc12
Show InChI InChI=1S/C17H19N/c1-18-11-10-17-15-8-4-2-6-13(15)12-14-7-3-5-9-16(14)17/h2-9,17-18H,10-12H2,1H3
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92 -39.9n/an/an/an/an/a7.423



Virginia Commonwealth University



Assay Description
Aliquots of radioligand are dispensed into the wells of 96-well plates. Then, duplicate aliquots of the test and reference compound dilutions are add...


Bioorg Med Chem 17: 6496-504 (2009)


Article DOI: 10.1016/j.bmc.2009.08.016
BindingDB Entry DOI: 10.7270/Q2QJ7FN6
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM82182
PNG
(3-[2-(4-{[3-(2-fluoroethoxy)-2-methoxyphenyl](hydr...)
Show SMILES COc1c(OCCF)cccc1C(O)C1CCN(CCn2c(=S)[nH]c3ccccc3c2=O)CC1
Show InChI InChI=1S/C25H30FN3O4S/c1-32-23-19(6-4-8-21(23)33-16-11-26)22(30)17-9-12-28(13-10-17)14-15-29-24(31)18-5-2-3-7-20(18)27-25(29)34/h2-8,17,22,30H,9-16H2,1H3,(H,27,34)
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356 -38.3n/an/an/an/an/a7.437



University of Mainz



Assay Description
5-HT-2A receptor affinity was determined by a radioligand competition binding assay with GF-62 cells, a clonal cell line expressing high amounts of 5...


Chem Biol Drug Des 76: 361-6 (2010)


Article DOI: 10.1111/j.1747-0285.2010.01011.x
BindingDB Entry DOI: 10.7270/Q2TX3CV8
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM82181
PNG
(3-(2-{4-[(2,3-dimethoxyphenyl)(hydroxy)methyl]pipe...)
Show SMILES COc1cccc(C(O)C2CCN(CCn3c(=S)[nH]c4ccccc4c3=O)CC2)c1OC
Show InChI InChI=1S/C24H29N3O4S/c1-30-20-9-5-7-18(22(20)31-2)21(28)16-10-12-26(13-11-16)14-15-27-23(29)17-6-3-4-8-19(17)25-24(27)32/h3-9,16,21,28H,10-15H2,1-2H3,(H,25,32)
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390 -38.1n/an/an/an/an/a7.437



University of Mainz



Assay Description
5-HT-2A receptor affinity was determined by a radioligand competition binding assay with GF-62 cells, a clonal cell line expressing high amounts of 5...


Chem Biol Drug Des 76: 361-6 (2010)


Article DOI: 10.1111/j.1747-0285.2010.01011.x
BindingDB Entry DOI: 10.7270/Q2TX3CV8
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM82184
PNG
(3-(2-{4-[(2,3-dimethoxyphenyl)carbonyl]piperidin-1...)
Show SMILES COc1cccc(C(=O)C2CCN(CCn3c(=S)[nH]c4ccccc4c3=O)CC2)c1OC
Show InChI InChI=1S/C24H27N3O4S/c1-30-20-9-5-7-18(22(20)31-2)21(28)16-10-12-26(13-11-16)14-15-27-23(29)17-6-3-4-8-19(17)25-24(27)32/h3-9,16H,10-15H2,1-2H3,(H,25,32)
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411 -37.9n/an/an/an/an/a7.437



University of Mainz



Assay Description
5-HT-2A receptor affinity was determined by a radioligand competition binding assay with GF-62 cells, a clonal cell line expressing high amounts of 5...


Chem Biol Drug Des 76: 361-6 (2010)


Article DOI: 10.1111/j.1747-0285.2010.01011.x
BindingDB Entry DOI: 10.7270/Q2TX3CV8
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM35923
PNG
(2-(9,10-Dihydro-anthracen-9-yl)-ethylamine | 9,10-...)
Show SMILES NCCC1c2ccccc2Cc2ccccc12
Show InChI InChI=1S/C16H17N/c17-10-9-16-14-7-3-1-5-12(14)11-13-6-2-4-8-15(13)16/h1-8,16H,9-11,17H2
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480 -35.8n/an/an/an/an/a7.423



Virginia Commonwealth University



Assay Description
Aliquots of radioligand are dispensed into the wells of 96-well plates. Then, duplicate aliquots of the test and reference compound dilutions are add...


Bioorg Med Chem 17: 6496-504 (2009)


Article DOI: 10.1016/j.bmc.2009.08.016
BindingDB Entry DOI: 10.7270/Q2QJ7FN6
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM35922
PNG
((9,10-Dihydro-anthracen-9-ylmethyl)-dimethyl-amine...)
Show SMILES CN(C)CC1c2ccccc2Cc2ccccc12
Show InChI InChI=1S/C17H19N/c1-18(2)12-17-15-9-5-3-7-13(15)11-14-8-4-6-10-16(14)17/h3-10,17H,11-12H2,1-2H3
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540 -35.5n/an/an/an/an/a7.423



Virginia Commonwealth University



Assay Description
Aliquots of radioligand are dispensed into the wells of 96-well plates. Then, duplicate aliquots of the test and reference compound dilutions are add...


Bioorg Med Chem 17: 6496-504 (2009)


Article DOI: 10.1016/j.bmc.2009.08.016
BindingDB Entry DOI: 10.7270/Q2QJ7FN6
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM35936
PNG
(diphenylalkylamine (DPA), 6b)
Show SMILES CNCCCC(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C17H21N/c1-18-14-8-13-17(15-9-4-2-5-10-15)16-11-6-3-7-12-16/h2-7,9-12,17-18H,8,13-14H2,1H3
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754 -34.7n/an/an/an/an/a7.423



Virginia Commonwealth University



Assay Description
Aliquots of radioligand are dispensed into the wells of 96-well plates. Then, duplicate aliquots of the test and reference compound dilutions are add...


Bioorg Med Chem 17: 6496-504 (2009)


Article DOI: 10.1016/j.bmc.2009.08.016
BindingDB Entry DOI: 10.7270/Q2QJ7FN6
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM35937
PNG
(diphenylalkylamine (DPA), 6c)
Show SMILES CN(C)CCCC(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C18H23N/c1-19(2)15-9-14-18(16-10-5-3-6-11-16)17-12-7-4-8-13-17/h3-8,10-13,18H,9,14-15H2,1-2H3
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PubMed
1.15E+3 -33.7n/an/an/an/an/a7.423



Virginia Commonwealth University



Assay Description
Aliquots of radioligand are dispensed into the wells of 96-well plates. Then, duplicate aliquots of the test and reference compound dilutions are add...


Bioorg Med Chem 17: 6496-504 (2009)


Article DOI: 10.1016/j.bmc.2009.08.016
BindingDB Entry DOI: 10.7270/Q2QJ7FN6
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM35933
PNG
(diphenylalkylamine (DPA), 5b)
Show SMILES CNCCC(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C16H19N/c1-17-13-12-16(14-8-4-2-5-9-14)15-10-6-3-7-11-15/h2-11,16-17H,12-13H2,1H3
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PubMed
1.50E+3 -33.0n/an/an/an/an/a7.423



Virginia Commonwealth University



Assay Description
Aliquots of radioligand are dispensed into the wells of 96-well plates. Then, duplicate aliquots of the test and reference compound dilutions are add...


Bioorg Med Chem 17: 6496-504 (2009)


Article DOI: 10.1016/j.bmc.2009.08.016
BindingDB Entry DOI: 10.7270/Q2QJ7FN6
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM35934
PNG
(diphenylalkylamine (DPA), 5c)
Show SMILES CN(C)CCC(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C17H21N/c1-18(2)14-13-17(15-9-5-3-6-10-15)16-11-7-4-8-12-16/h3-12,17H,13-14H2,1-2H3
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1.64E+3 -32.8n/an/an/an/an/a7.423



Virginia Commonwealth University



Assay Description
Aliquots of radioligand are dispensed into the wells of 96-well plates. Then, duplicate aliquots of the test and reference compound dilutions are add...


Bioorg Med Chem 17: 6496-504 (2009)


Article DOI: 10.1016/j.bmc.2009.08.016
BindingDB Entry DOI: 10.7270/Q2QJ7FN6
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM35935
PNG
(diphenylalkylamine (DPA), 6a)
Show SMILES NCCCC(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C16H19N/c17-13-7-12-16(14-8-3-1-4-9-14)15-10-5-2-6-11-15/h1-6,8-11,16H,7,12-13,17H2
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PubMed
2.59E+3 -31.7n/an/an/an/an/a7.423



Virginia Commonwealth University



Assay Description
Aliquots of radioligand are dispensed into the wells of 96-well plates. Then, duplicate aliquots of the test and reference compound dilutions are add...


Bioorg Med Chem 17: 6496-504 (2009)


Article DOI: 10.1016/j.bmc.2009.08.016
BindingDB Entry DOI: 10.7270/Q2QJ7FN6
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM35929
PNG
(2,2-Diphenyl-ethylamine | 2,2-diphenylethanamine |...)
Show SMILES NCC(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C14H15N/c15-11-14(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,14H,11,15H2
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PubMed
4.61E+3 -30.3n/an/an/an/an/a7.423



Virginia Commonwealth University



Assay Description
Aliquots of radioligand are dispensed into the wells of 96-well plates. Then, duplicate aliquots of the test and reference compound dilutions are add...


Bioorg Med Chem 17: 6496-504 (2009)


Article DOI: 10.1016/j.bmc.2009.08.016
BindingDB Entry DOI: 10.7270/Q2QJ7FN6
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM35931
PNG
(2,2-diphenylethyl(dimethyl)amine;hydrochloride | d...)
Show SMILES CN(C)CC(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C16H19N/c1-17(2)13-16(14-9-5-3-6-10-14)15-11-7-4-8-12-15/h3-12,16H,13H2,1-2H3
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PubMed
7.36E+3 -29.1n/an/an/an/an/a7.423



Virginia Commonwealth University



Assay Description
Aliquots of radioligand are dispensed into the wells of 96-well plates. Then, duplicate aliquots of the test and reference compound dilutions are add...


Bioorg Med Chem 17: 6496-504 (2009)


Article DOI: 10.1016/j.bmc.2009.08.016
BindingDB Entry DOI: 10.7270/Q2QJ7FN6
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM35930
PNG
(diphenylalkylamine (DPA), 4b)
Show SMILES CNCC(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C15H17N/c1-16-12-15(13-8-4-2-5-9-13)14-10-6-3-7-11-14/h2-11,15-16H,12H2,1H3
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PubMed
>1.00E+4>-28.3n/an/an/an/an/a7.423



Virginia Commonwealth University



Assay Description
Aliquots of radioligand are dispensed into the wells of 96-well plates. Then, duplicate aliquots of the test and reference compound dilutions are add...


Bioorg Med Chem 17: 6496-504 (2009)


Article DOI: 10.1016/j.bmc.2009.08.016
BindingDB Entry DOI: 10.7270/Q2QJ7FN6
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM35932
PNG
(diphenylalkylamine (DPA), 5a)
Show SMILES NCCC(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C15H17N/c16-12-11-15(13-7-3-1-4-8-13)14-9-5-2-6-10-14/h1-10,15H,11-12,16H2
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Article
PubMed
>1.00E+4>-28.3n/an/an/an/an/a7.423



Virginia Commonwealth University



Assay Description
Aliquots of radioligand are dispensed into the wells of 96-well plates. Then, duplicate aliquots of the test and reference compound dilutions are add...


Bioorg Med Chem 17: 6496-504 (2009)


Article DOI: 10.1016/j.bmc.2009.08.016
BindingDB Entry DOI: 10.7270/Q2QJ7FN6
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM117016
PNG
(US8664258, 32)
Show SMILES Cn1nccc1-c1cc(NC(=O)C(=O)c2ccc(F)cc2)ccc1OCCN
Show InChI InChI=1S/C20H19FN4O3/c1-25-17(8-10-23-25)16-12-15(6-7-18(16)28-11-9-22)24-20(27)19(26)13-2-4-14(21)5-3-13/h2-8,10,12H,9,11,22H2,1H3,(H,24,27)
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n/an/a 0.0250n/an/an/an/a7.425



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays for human 5-HT2A receptor was conducted using the 5-HT2 agonist [125]DOI as radioligand. To define nonspecific binding, 10...


US Patent US8664258 (2014)


BindingDB Entry DOI: 10.7270/Q2WQ02G1
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM117019
PNG
(US8664258, 303)
Show SMILES Cn1ncc(Cl)c1-c1cc(NC(=O)C2CCC(CC2)C(F)(F)F)ccc1OCCN
Show InChI InChI=1S/C20H24ClF3N4O2/c1-28-18(16(21)11-26-28)15-10-14(6-7-17(15)30-9-8-25)27-19(29)12-2-4-13(5-3-12)20(22,23)24/h6-7,10-13H,2-5,8-9,25H2,1H3,(H,27,29)
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n/an/a 0.260n/an/an/an/a7.425



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays for human 5-HT2A receptor was conducted using the 5-HT2 agonist [125]DOI as radioligand. To define nonspecific binding, 10...


US Patent US8664258 (2014)


BindingDB Entry DOI: 10.7270/Q2WQ02G1
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM117018
PNG
(US8664258, 197)
Show SMILES Cn1ncc(Cl)c1-c1cc(NC(=O)c2ccc(F)c(c2)C(F)(F)F)ccc1OCCN
Show InChI InChI=1S/C20H17ClF4N4O2/c1-29-18(15(21)10-27-29)13-9-12(3-5-17(13)31-7-6-26)28-19(30)11-2-4-16(22)14(8-11)20(23,24)25/h2-5,8-10H,6-7,26H2,1H3,(H,28,30)
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n/an/a 1n/an/an/an/a7.425



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays for human 5-HT2A receptor was conducted using the 5-HT2 agonist [125]DOI as radioligand. To define nonspecific binding, 10...


US Patent US8664258 (2014)


BindingDB Entry DOI: 10.7270/Q2WQ02G1
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM117020
PNG
(US8664258, 77)
Show SMILES Cn1ncc(Cl)c1-c1cc(NC(=O)C(=O)c2cc(Br)cs2)ccc1OCCN
Show InChI InChI=1S/C18H16BrClN4O3S/c1-24-16(13(20)8-22-24)12-7-11(2-3-14(12)27-5-4-21)23-18(26)17(25)15-6-10(19)9-28-15/h2-3,6-9H,4-5,21H2,1H3,(H,23,26)
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n/an/a 1.20n/an/an/an/a7.425



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays for human 5-HT2A receptor was conducted using the 5-HT2 agonist [125]DOI as radioligand. To define nonspecific binding, 10...


US Patent US8664258 (2014)


BindingDB Entry DOI: 10.7270/Q2WQ02G1
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM119678
PNG
(US8680119, 50)
Show SMILES COCCNC(=O)COc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1c(Cl)cnn1C
Show InChI InChI=1S/C23H22ClF3N4O4/c1-31-21(18(24)12-29-31)17-11-16(6-7-19(17)35-13-20(32)28-8-9-34-2)30-22(33)14-4-3-5-15(10-14)23(25,26)27/h3-7,10-12H,8-9,13H2,1-2H3,(H,28,32)(H,30,33)
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n/an/a 52n/an/an/an/a7.4n/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays for human 5-HT2A receptor was conducted using the 5-HT2 agonist [125I]DOI as radioligand. To define nonspecific binding, 1...


US Patent US8680119 (2014)


BindingDB Entry DOI: 10.7270/Q2RV0MB0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM119676
PNG
(US8680119, 15)
Show SMILES COCCNCCOc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1c(Cl)cnn1C
Show InChI InChI=1S/C23H24ClF3N4O3/c1-31-21(19(24)14-29-31)18-13-17(6-7-20(18)34-11-9-28-8-10-33-2)30-22(32)15-4-3-5-16(12-15)23(25,26)27/h3-7,12-14,28H,8-11H2,1-2H3,(H,30,32)
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n/an/a 0.0820n/an/an/an/a7.4n/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays for human 5-HT2A receptor was conducted using the 5-HT2 agonist [125I]DOI as radioligand. To define nonspecific binding, 1...


US Patent US8680119 (2014)


BindingDB Entry DOI: 10.7270/Q2RV0MB0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM119679
PNG
(US8680119, 68)
Show SMILES COc1cccc(c1)C(=O)Nc1ccc(OCCO)c(c1)-c1c(Cl)cnn1C
Show InChI InChI=1S/C20H20ClN3O4/c1-24-19(17(21)12-22-24)16-11-14(6-7-18(16)28-9-8-25)23-20(26)13-4-3-5-15(10-13)27-2/h3-7,10-12,25H,8-9H2,1-2H3,(H,23,26)
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n/an/a 0.510n/an/an/an/a7.4n/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays for human 5-HT2A receptor was conducted using the 5-HT2 agonist [125I]DOI as radioligand. To define nonspecific binding, 1...


US Patent US8680119 (2014)


BindingDB Entry DOI: 10.7270/Q2RV0MB0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM119677
PNG
(US8680119, 52)
Show SMILES COCCOc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1ccnn1C
Show InChI InChI=1S/C21H20F3N3O3/c1-27-18(8-9-25-27)17-13-16(6-7-19(17)30-11-10-29-2)26-20(28)14-4-3-5-15(12-14)21(22,23)24/h3-9,12-13H,10-11H2,1-2H3,(H,26,28)
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n/an/a 4.40n/an/an/an/a7.4n/a



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays for human 5-HT2A receptor was conducted using the 5-HT2 agonist [125I]DOI as radioligand. To define nonspecific binding, 1...


US Patent US8680119 (2014)


BindingDB Entry DOI: 10.7270/Q2RV0MB0
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Homo sapiens (human))
BDBM117017
PNG
(US8664258, 106)
Show SMILES Cn1nccc1-c1cc(NC(=O)c2ccno2)ccc1OCCN
Show InChI InChI=1S/C16H17N5O3/c1-21-13(4-7-18-21)12-10-11(2-3-14(12)23-9-6-17)20-16(22)15-5-8-19-24-15/h2-5,7-8,10H,6,9,17H2,1H3,(H,20,22)
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n/an/a 91n/an/an/an/a7.425



Arena Pharmaceuticals, Inc.

US Patent


Assay Description
Radioligand binding assays for human 5-HT2A receptor was conducted using the 5-HT2 agonist [125]DOI as radioligand. To define nonspecific binding, 10...


US Patent US8664258 (2014)


BindingDB Entry DOI: 10.7270/Q2WQ02G1
More data for this
Ligand-Target Pair