Affinity DataKi: 0.130nM ΔG°: -58.7kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
Affinity DataKi: 0.220nM ΔG°: -57.3kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
Affinity DataKi: 0.400nMpH: 7.4Assay Description:Binding experiments were conducted in 96-well microplates in a total volume of 250 μL of buffer (50 mM Tris-HCl pH 7.4, 10 mM MgCl2, 1 mM EDTA)....More data for this Ligand-Target Pair
Affinity DataKi: 0.5nM ΔG°: -55.2kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
Affinity DataKi: 0.900nM ΔG°: -53.7kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
Affinity DataKi: 1.10nM ΔG°: -53.2kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
Affinity DataKi: 4.14nM ΔG°: -49.8kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
Affinity DataKi: 6.64nM ΔG°: -48.6kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
Affinity DataKi: 7.10nM ΔG°: -48.4kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
Affinity DataKi: 11.4nM ΔG°: -47.2kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
Affinity DataKi: 15.2nM ΔG°: -46.4kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
Affinity DataKi: 21nM ΔG°: -45.6kJ/molepH: 7.4 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...More data for this Ligand-Target Pair
Affinity DataKi: 25.4nM ΔG°: -45.1kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
Affinity DataKi: 31nM ΔG°: -44.6kJ/molepH: 7.4 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...More data for this Ligand-Target Pair
Affinity DataKi: 40.1nM ΔG°: -43.9kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
Affinity DataKi: 46nM ΔG°: -43.6kJ/molepH: 7.4 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...More data for this Ligand-Target Pair
Affinity DataKi: 48.7nM ΔG°: -43.4kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
Affinity DataKi: 49.6nM ΔG°: -43.4kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
Affinity DataKi: 63.3nM ΔG°: -42.7kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
Affinity DataKi: 65.6nM ΔG°: -42.6kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
Affinity DataKi: 107nM ΔG°: -41.4kJ/molepH: 7.4 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...More data for this Ligand-Target Pair
Affinity DataKi: 128nM ΔG°: -40.9kJ/molepH: 7.4 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...More data for this Ligand-Target Pair
Affinity DataKi: 131nM ΔG°: -40.9kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
Affinity DataKi: 134nM ΔG°: -40.8kJ/molepH: 7.4 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...More data for this Ligand-Target Pair
Affinity DataKi: 221nM ΔG°: -39.5kJ/molepH: 7.4 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...More data for this Ligand-Target Pair
Affinity DataKi: 229nM ΔG°: -39.4kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
Affinity DataKi: 278nM ΔG°: -38.9kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
Affinity DataKi: 298nM ΔG°: -38.7kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
Affinity DataKi: 335nM ΔG°: -38.4kJ/molepH: 7.4 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...More data for this Ligand-Target Pair
Affinity DataKi: 338nM ΔG°: -38.4kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
Affinity DataKi: 468nMpH: 7.4Assay Description:The detailed experimental protocols for the radioligand and functional
receptor assays are available on the NIMH PDSP website at
http://pdsp.med.un...More data for this Ligand-Target Pair
Affinity DataKi: 538nM ΔG°: -37.2kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
Affinity DataKi: 679nM ΔG°: -34.9kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
Affinity DataKi: 1.20E+3nM ΔG°: -35.2kJ/molepH: 7.4 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...More data for this Ligand-Target Pair
Affinity DataKi: 1.82E+3nM ΔG°: -34.1kJ/molepH: 7.4 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...More data for this Ligand-Target Pair
Affinity DataKi: 2.81E+3nM ΔG°: -33.0kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
Affinity DataKi: 4.25E+3nM ΔG°: -31.9kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
Affinity DataKi: >5.00E+3nM ΔG°: >-31.5kJ/molepH: 7.4 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...More data for this Ligand-Target Pair
Affinity DataKi: >5.00E+3nM ΔG°: >-31.5kJ/molepH: 7.4 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein and test compounds. After incubation, the reaction stopped b...More data for this Ligand-Target Pair
Affinity DataKi: 5.10E+3nM ΔG°: -29.9kJ/molepH: 7.4 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
Affinity DataKi: 5.80E+3nM ΔG°: -29.6kJ/molepH: 7.4 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
Affinity DataKi: 6.90E+3nM ΔG°: -29.2kJ/molepH: 7.4 T: 2°CAssay Description:Competition experiments were performed in the presence radioligand with membrane protein (obtained from cells expressing the receptor) and test compo...More data for this Ligand-Target Pair
Affinity DataKi: 8.03E+3nM ΔG°: -30.3kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
Affinity DataKi: 8.18E+3nM ΔG°: -30.2kJ/molepH: 7.4 T: 2°CAssay Description:IC50 values for each test compound were determined from nonlinear regression analysis of data collected from ligand binding experiments. The inhibiti...More data for this Ligand-Target Pair
Affinity DataKi: >1.00E+4nMpH: 7.4Assay Description:The detailed experimental protocols for the radioligand and functional
receptor assays are available on the NIMH PDSP website at
http://pdsp.med.un...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMpH: 7.4 T: 2°CAssay Description:For receptor binding assays, human 5-HT6 and 5-HT7 serotonin receptors expressed in CHO-K1 cells (PerkinElmer) were used. For 5-HT6 receptor binding,...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMpH: 7.4 T: 2°CAssay Description:For receptor binding assays, human 5-HT6 and 5-HT7 serotonin receptors expressed in CHO-K1 cells (PerkinElmer) were used. For 5-HT6 receptor binding,...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMpH: 7.4 T: 2°CAssay Description:For receptor binding assays, human 5-HT6 and 5-HT7 serotonin receptors expressed in CHO-K1 cells (PerkinElmer) were used. For 5-HT6 receptor binding,...More data for this Ligand-Target Pair
Affinity DataIC50: 6.70E+3nMpH: 7.4 T: 2°CAssay Description:For receptor binding assays, human 5-HT6 and 5-HT7 serotonin receptors expressed in CHO-K1 cells (PerkinElmer) were used. For 5-HT6 receptor binding,...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMpH: 7.4 T: 2°CAssay Description:For receptor binding assays, human 5-HT6 and 5-HT7 serotonin receptors expressed in CHO-K1 cells (PerkinElmer) were used. For 5-HT6 receptor binding,...More data for this Ligand-Target Pair