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Compile Data Set for Download or QSAR

Found 237 hits of ph data with Target = 'ATP-sensitive inward rectifier potassium channel 1'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM161031
PNG
(US9108947, 1)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN[C@@H]1CCN(C[C@@H](O)c2ccc3C(=O)OCc3c2C)C1
Show InChI InChI=1S/C26H30N2O6/c1-14-17(3-5-19-21(14)12-33-25(19)31)23(29)9-27-16-7-8-28(10-16)11-24(30)18-4-6-20-22(15(18)2)13-34-26(20)32/h3-6,16,23-24,27,29-30H,7-13H2,1-2H3/t16-,23+,24-/m1/s1
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US Patent
n/an/a 595n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks.RT...


US Patent US9108947 (2015)


BindingDB Entry DOI: 10.7270/Q2V40SZT
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM161032
PNG
(US9108947, 2)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CNC1(CCC1)C1CCN(C[C@H](O)c2ccc3C(=O)OCc3c2C)C1
Show InChI InChI=1S/C30H36N2O6/c1-17-20(4-6-22-24(17)15-37-28(22)35)26(33)12-31-30(9-3-10-30)19-8-11-32(13-19)14-27(34)21-5-7-23-25(18(21)2)16-38-29(23)36/h4-7,19,26-27,31,33-34H,3,8-16H2,1-2H3/t19?,26-,27-/m0/s1
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n/an/a 420n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks.RT...


US Patent US9108947 (2015)


BindingDB Entry DOI: 10.7270/Q2V40SZT
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM161033
PNG
(US9108947, 3)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CNCC1CCCN1C[C@H](O)c1ccc2C(=O)OCc2c1C
Show InChI InChI=1S/C27H32N2O6/c1-15-18(5-7-20-22(15)13-34-26(20)32)24(30)11-28-10-17-4-3-9-29(17)12-25(31)19-6-8-21-23(16(19)2)14-35-27(21)33/h5-8,17,24-25,28,30-31H,3-4,9-14H2,1-2H3/t17?,24-,25-/m0/s1
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n/an/a 510n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks.RT...


US Patent US9108947 (2015)


BindingDB Entry DOI: 10.7270/Q2V40SZT
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM161034
PNG
(US9108947, 4)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCCC1CNC(CO)c1ccc2C(=O)OCc2c1C
Show InChI InChI=1S/C27H32N2O6/c1-15-18(5-7-20-22(15)13-34-26(20)32)24(12-30)28-10-17-4-3-9-29(17)11-25(31)19-6-8-21-23(16(19)2)14-35-27(21)33/h5-8,17,24-25,28,30-31H,3-4,9-14H2,1-2H3/t17?,24?,25-/m0/s1
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n/an/a 278n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks.RT...


US Patent US9108947 (2015)


BindingDB Entry DOI: 10.7270/Q2V40SZT
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM161035
PNG
(US9108947, 6)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCCCC1CNC(CO)c1ccc2C(=O)OCc2c1C
Show InChI InChI=1S/C28H34N2O6/c1-16-19(6-8-21-23(16)14-35-27(21)33)25(13-31)29-11-18-5-3-4-10-30(18)12-26(32)20-7-9-22-24(17(20)2)15-36-28(22)34/h6-9,18,25-26,29,31-32H,3-5,10-15H2,1-2H3/t18?,25?,26-/m0/s1
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n/an/a 446n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks.RT...


US Patent US9108947 (2015)


BindingDB Entry DOI: 10.7270/Q2V40SZT
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM161036
PNG
(US9108947, 9A | US9108947, 9B)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCCC1CNCC(O)c1ccc(cn1)C#N
Show InChI InChI=1S/C24H28N4O4/c1-15-18(5-6-19-20(15)14-32-24(19)31)23(30)13-28-8-2-3-17(28)11-26-12-22(29)21-7-4-16(9-25)10-27-21/h4-7,10,17,22-23,26,29-30H,2-3,8,11-14H2,1H3/t17?,22?,23-/m0/s1
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n/an/a 321n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks.RT...


US Patent US9108947 (2015)


BindingDB Entry DOI: 10.7270/Q2V40SZT
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM161036
PNG
(US9108947, 9A | US9108947, 9B)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCCC1CNCC(O)c1ccc(cn1)C#N
Show InChI InChI=1S/C24H28N4O4/c1-15-18(5-6-19-20(15)14-32-24(19)31)23(30)13-28-8-2-3-17(28)11-26-12-22(29)21-7-4-16(9-25)10-27-21/h4-7,10,17,22-23,26,29-30H,2-3,8,11-14H2,1H3/t17?,22?,23-/m0/s1
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n/an/a 254n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks.RT...


US Patent US9108947 (2015)


BindingDB Entry DOI: 10.7270/Q2V40SZT
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM161037
PNG
(US9108947, 10)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CC[C@H](C1)NCC(O)c1ccc(cn1)C#N
Show InChI InChI=1S/C23H26N4O4/c1-14-17(3-4-18-19(14)13-31-23(18)30)22(29)12-27-7-6-16(11-27)25-10-21(28)20-5-2-15(8-24)9-26-20/h2-5,9,16,21-22,25,28-29H,6-7,10-13H2,1H3/t16-,21?,22+/m1/s1
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n/an/a 2.06E+3n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks.RT...


US Patent US9108947 (2015)


BindingDB Entry DOI: 10.7270/Q2V40SZT
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM161038
PNG
(US9108947, 12)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN[C@@H]1CCN(CC(O)c2ccc(cn2)C#N)C1
Show InChI InChI=1S/C23H26N4O4/c1-14-17(3-4-18-19(14)13-31-23(18)30)21(28)10-25-16-6-7-27(11-16)12-22(29)20-5-2-15(8-24)9-26-20/h2-5,9,16,21-22,25,28-29H,6-7,10-13H2,1H3/t16-,21+,22?/m1/s1
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n/an/a 1.37E+3n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks.RT...


US Patent US9108947 (2015)


BindingDB Entry DOI: 10.7270/Q2V40SZT
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM161039
PNG
(US9108947, 13)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCCCC1CNCC(O)c1ccc(cn1)C#N
Show InChI InChI=1S/C25H30N4O4/c1-16-19(6-7-20-21(16)15-33-25(20)32)24(31)14-29-9-3-2-4-18(29)12-27-13-23(30)22-8-5-17(10-26)11-28-22/h5-8,11,18,23-24,27,30-31H,2-4,9,12-15H2,1H3/t18?,23?,24-/m0/s1
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n/an/a 269n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks.RT...


US Patent US9108947 (2015)


BindingDB Entry DOI: 10.7270/Q2V40SZT
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM161040
PNG
(US9108947, 14)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CC(CNS(=O)(=O)c2ccc(cc2)[N+]#[C-])C1
Show InChI InChI=1S/C22H23N3O5S/c1-14-18(7-8-19-20(14)13-30-22(19)27)21(26)12-25-10-15(11-25)9-24-31(28,29)17-5-3-16(23-2)4-6-17/h3-8,15,21,24,26H,9-13H2,1H3/t21-/m0/s1
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n/an/a 150n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks.RT...


US Patent US9108947 (2015)


BindingDB Entry DOI: 10.7270/Q2V40SZT
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM161041
PNG
(US9108947, 15)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CC[C@H](C1)NS(=O)(=O)c1ccc(cc1)[N+]#[C-]
Show InChI InChI=1S/C22H23N3O5S/c1-14-18(7-8-19-20(14)13-30-22(19)27)21(26)12-25-10-9-16(11-25)24-31(28,29)17-5-3-15(23-2)4-6-17/h3-8,16,21,24,26H,9-13H2,1H3/t16-,21+/m1/s1
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n/an/a 1.39E+3n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks.RT...


US Patent US9108947 (2015)


BindingDB Entry DOI: 10.7270/Q2V40SZT
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM161042
PNG
(US9108947, 17A)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CNC1C[C@H]2C[C@@H]1N(C[C@H](O)c1ccc3C(=O)OCc3c1C)C2
Show InChI InChI=1S/C28H32N2O6/c1-14-17(3-5-19-21(14)12-35-27(19)33)25(31)9-29-23-7-16-8-24(23)30(10-16)11-26(32)18-4-6-20-22(15(18)2)13-36-28(20)34/h3-6,16,23-26,29,31-32H,7-13H2,1-2H3/t16-,23?,24-,25-,26-/m0/s1
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n/an/a 1.42E+3n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks.RT...


US Patent US9108947 (2015)


BindingDB Entry DOI: 10.7270/Q2V40SZT
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM161043
PNG
(US9108947, 18)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCCC1CNc1ccc(cn1)[N+]#[C-]
Show InChI InChI=1S/C22H24N4O3/c1-14-17(6-7-18-19(14)13-29-22(18)28)20(27)12-26-9-3-4-16(26)11-25-21-8-5-15(23-2)10-24-21/h5-8,10,16,20,27H,3-4,9,11-13H2,1H3,(H,24,25)/t16?,20-/m0/s1
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n/an/a 65n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks.RT...


US Patent US9108947 (2015)


BindingDB Entry DOI: 10.7270/Q2V40SZT
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM161044
PNG
(US9108947, 19)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCCC1CNS(=O)(=O)c1ccc(cc1)-n1cnnn1
Show InChI InChI=1S/C23H26N6O5S/c1-15-19(8-9-20-21(15)13-34-23(20)31)22(30)12-28-10-2-3-17(28)11-25-35(32,33)18-6-4-16(5-7-18)29-14-24-26-27-29/h4-9,14,17,22,25,30H,2-3,10-13H2,1H3/t17?,22-/m0/s1
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n/an/a 245n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks.RT...


US Patent US9108947 (2015)


BindingDB Entry DOI: 10.7270/Q2V40SZT
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM161045
PNG
(US9108947, 20)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CNC1CCCN(C1)c1ccc(cn1)[N+]#[C-]
Show InChI InChI=1S/C22H24N4O3/c1-14-17(6-7-18-19(14)13-29-22(18)28)20(27)11-24-16-4-3-9-26(12-16)21-8-5-15(23-2)10-25-21/h5-8,10,16,20,24,27H,3-4,9,11-13H2,1H3/t16?,20-/m0/s1
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n/an/a 52n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks.RT...


US Patent US9108947 (2015)


BindingDB Entry DOI: 10.7270/Q2V40SZT
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM161046
PNG
(US9108947, 21)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC(C)(CNc2ccc(cn2)[N+]#[C-])C1
Show InChI InChI=1S/C23H26N4O3/c1-15-17(5-6-18-19(15)12-30-22(18)29)20(28)11-27-9-8-23(2,14-27)13-26-21-7-4-16(24-3)10-25-21/h4-7,10,20,28H,8-9,11-14H2,1-2H3,(H,25,26)/t20-,23?/m0/s1
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n/an/a 103n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks.RT...


US Patent US9108947 (2015)


BindingDB Entry DOI: 10.7270/Q2V40SZT
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM161047
PNG
(US9108947, 22)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCC(CNc2ccc(cn2)[N+]#[C-])(C1)c1ccccc1
Show InChI InChI=1S/C28H28N4O3/c1-19-22(9-10-23-24(19)16-35-27(23)34)25(33)15-32-13-12-28(18-32,20-6-4-3-5-7-20)17-31-26-11-8-21(29-2)14-30-26/h3-11,14,25,33H,12-13,15-18H2,1H3,(H,30,31)/t25-,28?/m0/s1
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n/an/a 340n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks.RT...


US Patent US9108947 (2015)


BindingDB Entry DOI: 10.7270/Q2V40SZT
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM181706
PNG
(US9139585, 1)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCN(C[C@H](O)c2ccc3C(=O)OCc3c2C)C2(CCCC2)C1
Show InChI InChI=1S/C30H36N2O6/c1-18-20(5-7-22-24(18)15-37-28(22)35)26(33)13-31-11-12-32(30(17-31)9-3-4-10-30)14-27(34)21-6-8-23-25(19(21)2)16-38-29(23)36/h5-8,26-27,33-34H,3-4,9-17H2,1-2H3/t26-,27-/m0/s1
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n/an/a 134n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


US Patent US9139585 (2015)


BindingDB Entry DOI: 10.7270/Q29P30F8
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM181707
PNG
(US9139585, 2)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCN(C[C@H](O)c2ccc3C(=O)OCc3c2C)C(C)(C)C1
Show InChI InChI=1S/C28H34N2O6/c1-16-18(5-7-20-22(16)13-35-26(20)33)24(31)11-29-9-10-30(28(3,4)15-29)12-25(32)19-6-8-21-23(17(19)2)14-36-27(21)34/h5-8,24-25,31-32H,9-15H2,1-4H3/t24-,25-/m0/s1
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n/an/a 41n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


US Patent US9139585 (2015)


BindingDB Entry DOI: 10.7270/Q29P30F8
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM181708
PNG
(US9139585, 3)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1C[C@@H]2C[C@H]1CN2S(=O)(=O)c1ccc(cc1)C#N
Show InChI InChI=1S/C23H23N3O5S/c1-14-19(6-7-20-21(14)13-31-23(20)28)22(27)12-25-10-17-8-16(25)11-26(17)32(29,30)18-4-2-15(9-24)3-5-18/h2-7,16-17,22,27H,8,10-13H2,1H3/t16-,17-,22-/m0/s1
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n/an/a 200n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


US Patent US9139585 (2015)


BindingDB Entry DOI: 10.7270/Q29P30F8
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM181710
PNG
(US9139585, 5)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1C2CCC1C1CCC2N1CC(O)c1ccc(cn1)C#N
Show InChI InChI=1S/C27H30N4O4/c1-15-17(3-4-18-19(15)14-35-27(18)34)25(32)12-30-21-6-7-22(30)24-9-8-23(21)31(24)13-26(33)20-5-2-16(10-28)11-29-20/h2-5,11,21-26,32-33H,6-9,12-14H2,1H3/t21?,22?,23?,24?,25-,26?/m0/s1
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n/an/a 197n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


US Patent US9139585 (2015)


BindingDB Entry DOI: 10.7270/Q29P30F8
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM181711
PNG
(US9139585, 6 | US9139585, 9)
Show SMILES COc1cc(ncc1C#N)C(O)CN1C2CCC1C1CCC2N1C[C@H](O)c1ccc2C(=O)OCc2c1C
Show InChI InChI=1S/C28H32N4O5/c1-15-17(3-4-18-19(15)14-37-28(18)35)25(33)12-31-21-5-6-22(31)24-8-7-23(21)32(24)13-26(34)20-9-27(36-2)16(10-29)11-30-20/h3-4,9,11,21-26,33-34H,5-8,12-14H2,1-2H3/t21?,22?,23?,24?,25-,26?/m0/s1
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n/an/a 21n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


US Patent US9139585 (2015)


BindingDB Entry DOI: 10.7270/Q29P30F8
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM181712
PNG
(US9139585, 7)
Show SMILES Cc1nc(ccc1C#N)C(O)CN1C2CCC1C1CCC2N1C[C@H](O)c1ccc2C(=O)OCc2c1C
Show InChI InChI=1S/C28H32N4O4/c1-15-18(4-5-19-20(15)14-36-28(19)35)26(33)12-31-22-7-8-23(31)25-10-9-24(22)32(25)13-27(34)21-6-3-17(11-29)16(2)30-21/h3-6,22-27,33-34H,7-10,12-14H2,1-2H3/t22?,23?,24?,25?,26-,27?/m0/s1
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n/an/a 45n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


US Patent US9139585 (2015)


BindingDB Entry DOI: 10.7270/Q29P30F8
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM181711
PNG
(US9139585, 6 | US9139585, 9)
Show SMILES COc1cc(ncc1C#N)C(O)CN1C2CCC1C1CCC2N1C[C@H](O)c1ccc2C(=O)OCc2c1C
Show InChI InChI=1S/C28H32N4O5/c1-15-17(3-4-18-19(15)14-37-28(18)35)25(33)12-31-21-5-6-22(31)24-8-7-23(21)32(24)13-26(34)20-9-27(36-2)16(10-29)11-30-20/h3-4,9,11,21-26,33-34H,5-8,12-14H2,1-2H3/t21?,22?,23?,24?,25-,26?/m0/s1
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n/an/a 23n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


US Patent US9139585 (2015)


BindingDB Entry DOI: 10.7270/Q29P30F8
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM181715
PNG
(US9139585, 10)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1[C@H]2CC[C@@H]1CN(C2)c1ccc(cn1)[N+]#[C-]
Show InChI InChI=1S/C23H24N4O3/c1-14-18(6-7-19-20(14)13-30-23(19)29)21(28)12-27-16-4-5-17(27)11-26(10-16)22-8-3-15(24-2)9-25-22/h3,6-9,16-17,21,28H,4-5,10-13H2,1H3/t16-,17+,21-/m0/s1
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n/an/a 316n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


US Patent US9139585 (2015)


BindingDB Entry DOI: 10.7270/Q29P30F8
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM181716
PNG
(US9139585, 11)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCN(CC1)c1ccc(cn1)[N+]#[C-]
Show InChI InChI=1S/C21H22N4O3/c1-14-16(4-5-17-18(14)13-28-21(17)27)19(26)12-24-7-9-25(10-8-24)20-6-3-15(22-2)11-23-20/h3-6,11,19,26H,7-10,12-13H2,1H3/t19-/m0/s1
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n/an/a 54n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


US Patent US9139585 (2015)


BindingDB Entry DOI: 10.7270/Q29P30F8
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM181717
PNG
(US9139585, 12)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1[C@H]2CC[C@@H]1CN(C2)C(=O)c1ccc(nc1)-n1cnnn1
Show InChI InChI=1S/C24H25N7O4/c1-14-18(5-6-19-20(14)12-35-24(19)34)21(32)11-30-16-3-4-17(30)10-29(9-16)23(33)15-2-7-22(25-8-15)31-13-26-27-28-31/h2,5-8,13,16-17,21,32H,3-4,9-12H2,1H3/t16-,17+,21-/m0/s1
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n/an/a 140n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


US Patent US9139585 (2015)


BindingDB Entry DOI: 10.7270/Q29P30F8
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM181718
PNG
(US9139585, 13)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1C2CCC1C1CCC2N1C(=O)c1ccc(nc1)-n1cnnn1
Show InChI InChI=1S/C26H27N7O4/c1-14-16(3-4-17-18(14)12-37-26(17)36)23(34)11-31-19-5-6-20(31)22-8-7-21(19)33(22)25(35)15-2-9-24(27-10-15)32-13-28-29-30-32/h2-4,9-10,13,19-23,34H,5-8,11-12H2,1H3/t19?,20?,21?,22?,23-/m0/s1
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n/an/a 130n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


US Patent US9139585 (2015)


BindingDB Entry DOI: 10.7270/Q29P30F8
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM181719
PNG
(US9139585, 14)
Show SMILES Cc1cc(ccc1-n1cnnn1)S(=O)(=O)N1C[C@@H]2C[C@H]1CN2C[C@H](O)c1ccc2C(=O)OCc2c1C
Show InChI InChI=1S/C24H26N6O5S/c1-14-7-18(3-6-22(14)29-13-25-26-27-29)36(33,34)30-10-16-8-17(30)9-28(16)11-23(31)19-4-5-20-21(15(19)2)12-35-24(20)32/h3-7,13,16-17,23,31H,8-12H2,1-2H3/t16-,17-,23-/m0/s1
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n/an/a 270n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


US Patent US9139585 (2015)


BindingDB Entry DOI: 10.7270/Q29P30F8
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM181720
PNG
(US9139585, 15)
Show SMILES Cc1cc(ccc1-n1cnnn1)S(=O)(=O)N1[C@H]2CC[C@@H]1CN(C[C@H](O)c1ccc3C(=O)OCc3c1C)C2
Show InChI InChI=1S/C25H28N6O5S/c1-15-9-19(5-8-23(15)30-14-26-27-28-30)37(34,35)31-17-3-4-18(31)11-29(10-17)12-24(32)20-6-7-21-22(16(20)2)13-36-25(21)33/h5-9,14,17-18,24,32H,3-4,10-13H2,1-2H3/t17-,18+,24-/m0/s1
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n/an/a 150n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


US Patent US9139585 (2015)


BindingDB Entry DOI: 10.7270/Q29P30F8
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM181721
PNG
(US9139585, 16)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1C[C@@H]2CC[C@H](C1)N2S(=O)(=O)c1ccc(cc1)-n1cnnn1
Show InChI InChI=1S/C24H26N6O5S/c1-15-20(8-9-21-22(15)13-35-24(21)32)23(31)12-28-10-17-2-3-18(11-28)30(17)36(33,34)19-6-4-16(5-7-19)29-14-25-26-27-29/h4-9,14,17-18,23,31H,2-3,10-13H2,1H3/t17-,18+,23-/m0/s1
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n/an/a 54n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


US Patent US9139585 (2015)


BindingDB Entry DOI: 10.7270/Q29P30F8
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM181722
PNG
(US9139585, 17A)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CC2CCC1CN2S(=O)(=O)c1ccc(cc1)-n1cnnn1
Show InChI InChI=1S/C24H26N6O5S/c1-15-20(8-9-21-22(15)13-35-24(21)32)23(31)12-28-10-18-3-2-17(28)11-30(18)36(33,34)19-6-4-16(5-7-19)29-14-25-26-27-29/h4-9,14,17-18,23,31H,2-3,10-13H2,1H3/t17?,18?,23-/m0/s1
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n/an/a 170n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


US Patent US9139585 (2015)


BindingDB Entry DOI: 10.7270/Q29P30F8
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM181723
PNG
(US9139585, 18)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CC2COCC(C1)N2C[C@H](O)c1ccc2C(=O)OCc2c1C
Show InChI InChI=1S/C28H32N2O7/c1-15-19(3-5-21-23(15)13-36-27(21)33)25(31)9-29-7-17-11-35-12-18(8-29)30(17)10-26(32)20-4-6-22-24(16(20)2)14-37-28(22)34/h3-6,17-18,25-26,31-32H,7-14H2,1-2H3/t17?,18?,25-,26-/m0/s1
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n/an/a 30n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


US Patent US9139585 (2015)


BindingDB Entry DOI: 10.7270/Q29P30F8
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM181725
PNG
(US9139585, 20)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CC2COCC(C1)N2CC(O)c1ccc(cn1)[N+]#[C-]
Show InChI InChI=1S/C25H28N4O5/c1-15-19(4-5-20-21(15)14-34-25(20)32)23(30)10-28-8-17-12-33-13-18(9-28)29(17)11-24(31)22-6-3-16(26-2)7-27-22/h3-7,17-18,23-24,30-31H,8-14H2,1H3/t17?,18?,23-,24?/m0/s1
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n/an/a 29.5n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


US Patent US9139585 (2015)


BindingDB Entry DOI: 10.7270/Q29P30F8
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM181726
PNG
(US9139585, 21)
Show SMILES C[C@@H]1Cc2cc(CCN3CC4COCC(C3)N4C[C@H](O)c3ccc4C(=O)OCc4c3C)ccc2C(=O)O1
Show InChI InChI=1S/C29H34N2O6/c1-17-9-20-10-19(3-4-24(20)29(34)37-17)7-8-30-11-21-14-35-15-22(12-30)31(21)13-27(32)23-5-6-25-26(18(23)2)16-36-28(25)33/h3-6,10,17,21-22,27,32H,7-9,11-16H2,1-2H3/t17-,21?,22?,27+/m1/s1
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n/an/a 45n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


US Patent US9139585 (2015)


BindingDB Entry DOI: 10.7270/Q29P30F8
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM181727
PNG
(US9139585, 22)
Show SMILES C[C@H]1Cc2cc(CCN3CC4COCC(C3)N4C[C@H](O)c3ccc4C(=O)OCc4c3C)ccc2C(=O)O1
Show InChI InChI=1S/C29H34N2O6/c1-17-9-20-10-19(3-4-24(20)29(34)37-17)7-8-30-11-21-14-35-15-22(12-30)31(21)13-27(32)23-5-6-25-26(18(23)2)16-36-28(25)33/h3-6,10,17,21-22,27,32H,7-9,11-16H2,1-2H3/t17-,21?,22?,27-/m0/s1
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n/an/a 32n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


US Patent US9139585 (2015)


BindingDB Entry DOI: 10.7270/Q29P30F8
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM181728
PNG
(US9139585, 23A)
Show SMILES C[C@H]1Cc2cc(ccc2C(=O)O1)C(O)CN1CC2COCC(C1)N2C[C@H](O)c1ccc2C(=O)OCc2c1C
Show InChI InChI=1S/C29H34N2O7/c1-16-7-19-8-18(3-4-23(19)29(35)38-16)26(32)11-30-9-20-13-36-14-21(10-30)31(20)12-27(33)22-5-6-24-25(17(22)2)15-37-28(24)34/h3-6,8,16,20-21,26-27,32-33H,7,9-15H2,1-2H3/t16-,20?,21?,26?,27-/m0/s1
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n/an/a 2.46E+3n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


US Patent US9139585 (2015)


BindingDB Entry DOI: 10.7270/Q29P30F8
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM181756
PNG
(US9139585, 23B)
Show SMILES C[C@@H]1Cc2cc(ccc2C(=O)O1)C(O)CN1CC2COCC(C1)N2C[C@H](O)c1ccc2C(=O)OCc2c1C
Show InChI InChI=1S/C29H34N2O7/c1-16-7-19-8-18(3-4-23(19)29(35)38-16)26(32)11-30-9-20-13-36-14-21(10-30)31(20)12-27(33)22-5-6-24-25(17(22)2)15-37-28(24)34/h3-6,8,16,20-21,26-27,32-33H,7,9-15H2,1-2H3/t16-,20?,21?,26?,27+/m1/s1
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n/an/a 64n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


US Patent US9139585 (2015)


BindingDB Entry DOI: 10.7270/Q29P30F8
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM181757
PNG
(US9139585, 24B)
Show SMILES C[C@H]1Cc2cc(ccc2C(=O)O1)C(O)CC1CC2COCC(C1)N2C[C@H](O)c1ccc2C(=O)OCc2c1C
Show InChI InChI=1S/C30H35NO7/c1-16-7-20-11-19(3-4-24(20)30(35)38-16)27(32)10-18-8-21-13-36-14-22(9-18)31(21)12-28(33)23-5-6-25-26(17(23)2)15-37-29(25)34/h3-6,11,16,18,21-22,27-28,32-33H,7-10,12-15H2,1-2H3/t16-,18?,21?,22?,27?,28-/m0/s1
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n/an/a 66n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


US Patent US9139585 (2015)


BindingDB Entry DOI: 10.7270/Q29P30F8
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM181730
PNG
(US9139585, 25 | US9139585, 26)
Show SMILES COc1cc(ncc1[N+]#[C-])C(O)CN1C2COCC1CN(C[C@H](O)c1ccc3C(=O)OCc3c1C)C2
Show InChI InChI=1S/C26H30N4O6/c1-15-18(4-5-19-20(15)14-36-26(19)33)23(31)10-29-8-16-12-35-13-17(9-29)30(16)11-24(32)21-6-25(34-3)22(27-2)7-28-21/h4-7,16-17,23-24,31-32H,8-14H2,1,3H3/t16?,17?,23-,24?/m0/s1
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n/an/a 110n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


US Patent US9139585 (2015)


BindingDB Entry DOI: 10.7270/Q29P30F8
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM181730
PNG
(US9139585, 25 | US9139585, 26)
Show SMILES COc1cc(ncc1[N+]#[C-])C(O)CN1C2COCC1CN(C[C@H](O)c1ccc3C(=O)OCc3c1C)C2
Show InChI InChI=1S/C26H30N4O6/c1-15-18(4-5-19-20(15)14-36-26(19)33)23(31)10-29-8-16-12-35-13-17(9-29)30(16)11-24(32)21-6-25(34-3)22(27-2)7-28-21/h4-7,16-17,23-24,31-32H,8-14H2,1,3H3/t16?,17?,23-,24?/m0/s1
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n/an/a 71n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


US Patent US9139585 (2015)


BindingDB Entry DOI: 10.7270/Q29P30F8
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM181733
PNG
(US9139585, 28)
Show SMILES C[C@@H]1Cc2cc(CCN3CCN(C[C@H](O)c4ccc5C(=O)OCc5c4C)CC3)ccc2C(=O)O1
Show InChI InChI=1S/C27H32N2O5/c1-17-13-20-14-19(3-4-22(20)27(32)34-17)7-8-28-9-11-29(12-10-28)15-25(30)21-5-6-23-24(18(21)2)16-33-26(23)31/h3-6,14,17,25,30H,7-13,15-16H2,1-2H3/t17-,25+/m1/s1
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n/an/a 33n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


US Patent US9139585 (2015)


BindingDB Entry DOI: 10.7270/Q29P30F8
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM181735
PNG
(US9139585, 29)
Show SMILES C[C@@H]1Cc2cc(CCN3CCN(C[C@@H](O)c4ccc5C(=O)OCc5c4C)CC3)ccc2C(=O)O1
Show InChI InChI=1S/C27H32N2O5/c1-17-13-20-14-19(3-4-22(20)27(32)34-17)7-8-28-9-11-29(12-10-28)15-25(30)21-5-6-23-24(18(21)2)16-33-26(23)31/h3-6,14,17,25,30H,7-13,15-16H2,1-2H3/t17-,25-/m1/s1
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n/an/a 145n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


US Patent US9139585 (2015)


BindingDB Entry DOI: 10.7270/Q29P30F8
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM181737
PNG
(US9139585, 30)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCN(CCc2ccc3C(=O)OCCc3c2)CC1
Show InChI InChI=1S/C26H30N2O5/c1-17-20(4-5-22-23(17)16-33-26(22)31)24(29)15-28-11-9-27(10-12-28)8-6-18-2-3-21-19(14-18)7-13-32-25(21)30/h2-5,14,24,29H,6-13,15-16H2,1H3/t24-/m0/s1
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n/an/a 21n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


US Patent US9139585 (2015)


BindingDB Entry DOI: 10.7270/Q29P30F8
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM181739
PNG
(US9139585, 31)
Show SMILES Cc1c2COC(=O)c2ccc1[C@H](O)CN1CCN(CCc2ccc3C(=O)OCCc3c2)CC1
Show InChI InChI=1S/C26H30N2O5/c1-17-20(4-5-22-23(17)16-33-26(22)31)24(29)15-28-11-9-27(10-12-28)8-6-18-2-3-21-19(14-18)7-13-32-25(21)30/h2-5,14,24,29H,6-13,15-16H2,1H3/t24-/m1/s1
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n/an/a 564n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


US Patent US9139585 (2015)


BindingDB Entry DOI: 10.7270/Q29P30F8
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM181741
PNG
(US9139585, 32)
Show SMILES CCc1c2COC(=O)c2ccc1C(O)CN1CCN(CCc2ccc3C(=O)OCCc3c2)CC1
Show InChI InChI=1S/C27H32N2O5/c1-2-20-22(5-6-23-24(20)17-34-27(23)32)25(30)16-29-12-10-28(11-13-29)9-7-18-3-4-21-19(15-18)8-14-33-26(21)31/h3-6,15,25,30H,2,7-14,16-17H2,1H3
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n/an/a 46n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


US Patent US9139585 (2015)


BindingDB Entry DOI: 10.7270/Q29P30F8
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM181743
PNG
(US9139585, 33)
Show SMILES OC(CN1CCN(CCc2ccc3C(=O)OCCc3c2)CC1)c1ccc2C(=O)OCc2c1C(F)(F)F
Show InChI InChI=1S/C26H27F3N2O5/c27-26(28,29)23-20(4-3-19-21(23)15-36-25(19)34)22(32)14-31-10-8-30(9-11-31)7-5-16-1-2-18-17(13-16)6-12-35-24(18)33/h1-4,13,22,32H,5-12,14-15H2
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n/an/a 38n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


US Patent US9139585 (2015)


BindingDB Entry DOI: 10.7270/Q29P30F8
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM181744
PNG
(US9139585, 34A)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCN(C[C@H](O)c2ccc(nc2)-n2cnnn2)CC1
Show InChI InChI=1S/C23H27N7O4/c1-15-17(3-4-18-19(15)13-34-23(18)33)21(32)12-29-8-6-28(7-9-29)11-20(31)16-2-5-22(24-10-16)30-14-25-26-27-30/h2-5,10,14,20-21,31-32H,6-9,11-13H2,1H3/t20-,21-/m0/s1
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n/an/a 35n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


US Patent US9139585 (2015)


BindingDB Entry DOI: 10.7270/Q29P30F8
More data for this
Ligand-Target Pair
ATP-sensitive inward rectifier potassium channel 1


(Homo sapiens)
BDBM181758
PNG
(US9139585, 34B)
Show SMILES Cc1c2COC(=O)c2ccc1[C@@H](O)CN1CCN(C[C@@H](O)c2ccc(nc2)-n2cnnn2)CC1
Show InChI InChI=1S/C23H27N7O4/c1-15-17(3-4-18-19(15)13-34-23(18)33)21(32)12-29-8-6-28(7-9-29)11-20(31)16-2-5-22(24-10-16)30-14-25-26-27-30/h2-5,10,14,20-21,31-32H,6-9,11-13H2,1H3/t20-,21+/m1/s1
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n/an/a 14n/an/an/an/a7.437



Merck Sharp & Dohme Corp.

US Patent


Assay Description
Block of Kir1.1 (ROMK1) currents was examined by whole cell voltage clamp (Hamill et. al. Pfluegers Archives 391:85-100 (1981)) using the IonWorks Qu...


US Patent US9139585 (2015)


BindingDB Entry DOI: 10.7270/Q29P30F8
More data for this
Ligand-Target Pair
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