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Found 148 hits of ph data with Target = 'Acetyl-coenzyme A transporter 1 (AT1)'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107458
PNG
(US8592431, 428)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(C2CC[C@@H](CC2)OCC(O)C(F)(F)F)c2ccnn12
Show InChI InChI=1S/C33H34F3N5O5/c1-2-5-27-26(18-20-8-10-21(11-9-20)24-6-3-4-7-25(24)30-38-32(44)46-39-30)31(43)40(29-16-17-37-41(27)29)22-12-14-23(15-13-22)45-19-28(42)33(34,35)36/h3-4,6-11,16-17,22-23,28,42H,2,5,12-15,18-19H2,1H3,(H,38,39,44)/t22?,23-,28?
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107459
PNG
(US8592431, 434)
Show SMILES CCCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(C2CC[C@@H](CC2)OCC(C)(C)O)c2ccnn12
Show InChI InChI=1S/C35H41N5O5/c1-4-5-10-30-29(21-23-11-13-24(14-12-23)27-8-6-7-9-28(27)32-37-34(42)45-38-32)33(41)39(31-19-20-36-40(30)31)25-15-17-26(18-16-25)44-22-35(2,3)43/h6-9,11-14,19-20,25-26,43H,4-5,10,15-18,21-22H2,1-3H3,(H,37,38,42)/t25?,26-
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107460
PNG
(US8592431, 435)
Show SMILES CCCc1c(Cc2ccc(cc2F)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(C2CC[C@@H](CC2)OCC(C)(C)O)c2ccnn12
Show InChI InChI=1S/C34H38FN5O5/c1-4-7-29-27(18-22-11-10-21(19-28(22)35)25-8-5-6-9-26(25)31-37-33(42)45-38-31)32(41)39(30-16-17-36-40(29)30)23-12-14-24(15-13-23)44-20-34(2,3)43/h5-6,8-11,16-17,19,23-24,43H,4,7,12-15,18,20H2,1-3H3,(H,37,38,42)/t23?,24-
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107461
PNG
(US8592431, 436)
Show SMILES CCCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(C2CC[C@@H](CC2)OCC(C)O)c2ccnn12
Show InChI InChI=1S/C34H39N5O5/c1-3-4-9-30-29(20-23-10-12-24(13-11-23)27-7-5-6-8-28(27)32-36-34(42)44-37-32)33(41)38(31-18-19-35-39(30)31)25-14-16-26(17-15-25)43-21-22(2)40/h5-8,10-13,18-19,22,25-26,40H,3-4,9,14-17,20-21H2,1-2H3,(H,36,37,42)/t22?,25?,26-
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107462
PNG
(US8592431, 437)
Show SMILES CCCc1c(Cc2ccc(cc2F)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(C2CC[C@@H](CC2)OCC(C)O)c2ccnn12
Show InChI InChI=1S/C33H36FN5O5/c1-3-6-29-27(32(41)38(30-15-16-35-39(29)30)23-11-13-24(14-12-23)43-19-20(2)40)17-22-10-9-21(18-28(22)34)25-7-4-5-8-26(25)31-36-33(42)44-37-31/h4-5,7-10,15-16,18,20,23-24,40H,3,6,11-14,17,19H2,1-2H3,(H,36,37,42)/t20?,23?,24-
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107463
PNG
(US8592431, 520 | US8592431, 521)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(C2CC[C@@H](CC2)OCC(C)O)c2ccnn12
Show InChI InChI=1S/C33H37N5O5/c1-3-6-29-28(19-22-9-11-23(12-10-22)26-7-4-5-8-27(26)31-35-33(41)43-36-31)32(40)37(30-17-18-34-38(29)30)24-13-15-25(16-14-24)42-20-21(2)39/h4-5,7-12,17-18,21,24-25,39H,3,6,13-16,19-20H2,1-2H3,(H,35,36,41)/t21?,24?,25-
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107463
PNG
(US8592431, 520 | US8592431, 521)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(C2CC[C@@H](CC2)OCC(C)O)c2ccnn12
Show InChI InChI=1S/C33H37N5O5/c1-3-6-29-28(19-22-9-11-23(12-10-22)26-7-4-5-8-27(26)31-35-33(41)43-36-31)32(40)37(30-17-18-34-38(29)30)24-13-15-25(16-14-24)42-20-21(2)39/h4-5,7-12,17-18,21,24-25,39H,3,6,13-16,19-20H2,1-2H3,(H,35,36,41)/t21?,24?,25-
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107465
PNG
(US8592431, 442)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(C2CC[C@@H](CC2)OCC(C)(C)O)c2c(F)cnn12
Show InChI InChI=1S/C34H38FN5O5/c1-4-7-29-27(18-21-10-12-22(13-11-21)25-8-5-6-9-26(25)30-37-33(42)45-38-30)32(41)39(31-28(35)19-36-40(29)31)23-14-16-24(17-15-23)44-20-34(2,3)43/h5-6,8-13,19,23-24,43H,4,7,14-18,20H2,1-3H3,(H,37,38,42)/t23?,24-
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107466
PNG
(US8592431, 457)
Show SMILES CCCCc1c(Cc2ccc(cc2F)-c2ccccc2-c2nnn[nH]2)c(=O)n([C@H]2CC[C@@H](CC2)OCC(C)(C)O)c2ncnn12
Show InChI InChI=1S/C33H39FN8O3/c1-4-5-10-29-27(17-22-12-11-21(18-28(22)34)25-8-6-7-9-26(25)30-37-39-40-38-30)31(43)41(32-35-20-36-42(29)32)23-13-15-24(16-14-23)45-19-33(2,3)44/h6-9,11-12,18,20,23-24,44H,4-5,10,13-17,19H2,1-3H3,(H,37,38,39,40)/t23-,24-
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107351
PNG
(US8592431, 139)
Show SMILES CCCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n([C@@H]2C[C@H](C)O[C@H](C)C2)c2ncnn12
Show InChI InChI=1S/C31H34N6O4/c1-4-5-10-27-26(29(38)36(30-32-18-33-37(27)30)23-15-19(2)40-20(3)16-23)17-21-11-13-22(14-12-21)24-8-6-7-9-25(24)28-34-31(39)41-35-28/h6-9,11-14,18-20,23H,4-5,10,15-17H2,1-3H3,(H,34,35,39)/t19-,20+,23+
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107353
PNG
(US8592431, 144)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(C2CCC(C)OC2)c2nc(C)nn12
Show InChI InChI=1S/C30H32N6O4/c1-4-7-26-25(28(37)35(22-15-10-18(2)39-17-22)29-31-19(3)33-36(26)29)16-20-11-13-21(14-12-20)23-8-5-6-9-24(23)27-32-30(38)40-34-27/h5-6,8-9,11-14,18,22H,4,7,10,15-17H2,1-3H3,(H,32,34,38)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107354
PNG
(US8592431, 147)
Show SMILES CCCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(C2CCC(O)CC2)c2ncnn12
Show InChI InChI=1S/C30H32N6O4/c1-2-3-8-26-25(28(38)35(29-31-18-32-36(26)29)21-13-15-22(37)16-14-21)17-19-9-11-20(12-10-19)23-6-4-5-7-24(23)27-33-30(39)40-34-27/h4-7,9-12,18,21-22,37H,2-3,8,13-17H2,1H3,(H,33,34,39)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107355
PNG
(US8592431, 148)
Show SMILES CCCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(C2CCC(CC2)OC)c2ncnn12
Show InChI InChI=1S/C31H34N6O4/c1-3-4-9-27-26(29(38)36(30-32-19-33-37(27)30)22-14-16-23(40-2)17-15-22)18-20-10-12-21(13-11-20)24-7-5-6-8-25(24)28-34-31(39)41-35-28/h5-8,10-13,19,22-23H,3-4,9,14-18H2,1-2H3,(H,34,35,39)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107356
PNG
(US8592431, 150)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n([C@H]2CC[C@]3(CCCO3)CC2)c2ncnn12
Show InChI InChI=1S/C32H34N6O4/c1-2-6-27-26(19-21-9-11-22(12-10-21)24-7-3-4-8-25(24)28-35-31(40)42-36-28)29(39)37(30-33-20-34-38(27)30)23-13-16-32(17-14-23)15-5-18-41-32/h3-4,7-12,20,23H,2,5-6,13-19H2,1H3,(H,35,36,40)/t23-,32+
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107357
PNG
(US8592431, 151)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n([C@H]2CC[C@@]3(CCCO3)CC2)c2ncnn12
Show InChI InChI=1S/C32H34N6O4/c1-2-6-27-26(19-21-9-11-22(12-10-21)24-7-3-4-8-25(24)28-35-31(40)42-36-28)29(39)37(30-33-20-34-38(27)30)23-13-16-32(17-14-23)15-5-18-41-32/h3-4,7-12,20,23H,2,5-6,13-19H2,1H3,(H,35,36,40)/t23-,32-
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107358
PNG
(US8592431, 152)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(C2CCC(CC2)OC)c2ncnn12
Show InChI InChI=1S/C30H32N6O4/c1-3-6-26-25(28(37)35(29-31-18-32-36(26)29)21-13-15-22(39-2)16-14-21)17-19-9-11-20(12-10-19)23-7-4-5-8-24(23)27-33-30(38)40-34-27/h4-5,7-12,18,21-22H,3,6,13-17H2,1-2H3,(H,33,34,38)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107359
PNG
(US8592431, 153)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(C2CCC(CC2)OCC=C)c2ncnn12
Show InChI InChI=1S/C32H34N6O4/c1-3-7-28-27(30(39)37(31-33-20-34-38(28)31)23-14-16-24(17-15-23)41-18-4-2)19-21-10-12-22(13-11-21)25-8-5-6-9-26(25)29-35-32(40)42-36-29/h4-6,8-13,20,23-24H,2-3,7,14-19H2,1H3,(H,35,36,40)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107360
PNG
(US8592431, 158)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n([C@@H]2CC[C@@H](CC2)OCC(C)(C)O)c2ncnn12
Show InChI InChI=1S/C33H38N6O5/c1-4-7-28-27(18-21-10-12-22(13-11-21)25-8-5-6-9-26(25)29-36-32(41)44-37-29)30(40)38(31-34-20-35-39(28)31)23-14-16-24(17-15-23)43-19-33(2,3)42/h5-6,8-13,20,23-24,42H,4,7,14-19H2,1-3H3,(H,36,37,41)/t23-,24+
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107361
PNG
(US8592431, 241 | US8592431, 242)
Show SMILES CCCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(C2CCOC(C)C2)c2ncnn12
Show InChI InChI=1S/C30H32N6O4/c1-3-4-9-26-25(28(37)35(29-31-18-32-36(26)29)22-14-15-39-19(2)16-22)17-20-10-12-21(13-11-20)23-7-5-6-8-24(23)27-33-30(38)40-34-27/h5-8,10-13,18-19,22H,3-4,9,14-17H2,1-2H3,(H,33,34,38)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107361
PNG
(US8592431, 241 | US8592431, 242)
Show SMILES CCCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(C2CCOC(C)C2)c2ncnn12
Show InChI InChI=1S/C30H32N6O4/c1-3-4-9-26-25(28(37)35(29-31-18-32-36(26)29)22-14-15-39-19(2)16-22)17-20-10-12-21(13-11-20)23-7-5-6-8-24(23)27-33-30(38)40-34-27/h5-8,10-13,18-19,22H,3-4,9,14-17H2,1-2H3,(H,33,34,38)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107363
PNG
(US8592431, 163)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n([C@@H]2CC[C@@H](CC2)OCCO)c2ncnn12
Show InChI InChI=1S/C31H34N6O5/c1-2-5-27-26(29(39)36(30-32-19-33-37(27)30)22-12-14-23(15-13-22)41-17-16-38)18-20-8-10-21(11-9-20)24-6-3-4-7-25(24)28-34-31(40)42-35-28/h3-4,6-11,19,22-23,38H,2,5,12-18H2,1H3,(H,34,35,40)/t22-,23+
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107364
PNG
(US8592431, 264)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n([C@H]2CC[C@@H](CC2)OCCO)c2ncnn12
Show InChI InChI=1S/C31H34N6O5/c1-2-5-27-26(29(39)36(30-32-19-33-37(27)30)22-12-14-23(15-13-22)41-17-16-38)18-20-8-10-21(11-9-20)24-6-3-4-7-25(24)28-34-31(40)42-35-28/h3-4,6-11,19,22-23,38H,2,5,12-18H2,1H3,(H,34,35,40)/t22-,23-
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107365
PNG
(US8592431, 166)
Show SMILES CCCc1c(Cc2ccc(cc2F)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n([C@@H]2CC[C@H](O)CC2)c2ncnn12
Show InChI InChI=1S/C29H29FN6O4/c1-2-5-25-23(27(38)35(28-31-16-32-36(25)28)19-10-12-20(37)13-11-19)14-18-9-8-17(15-24(18)30)21-6-3-4-7-22(21)26-33-29(39)40-34-26/h3-4,6-9,15-16,19-20,37H,2,5,10-14H2,1H3,(H,33,34,39)/t19-,20+
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107366
PNG
(US8592431, 167)
Show SMILES CCCc1c(Cc2ccc(cc2F)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n([C@H]2CC[C@H](O)CC2)c2ncnn12
Show InChI InChI=1S/C29H29FN6O4/c1-2-5-25-23(27(38)35(28-31-16-32-36(25)28)19-10-12-20(37)13-11-19)14-18-9-8-17(15-24(18)30)21-6-3-4-7-22(21)26-33-29(39)40-34-26/h3-4,6-9,15-16,19-20,37H,2,5,10-14H2,1H3,(H,33,34,39)/t19-,20-
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107367
PNG
(US8592431, 168)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n([C@H]2CC[C@@H](CC2)C(=O)OCC)c2ncnn12
Show InChI InChI=1S/C32H34N6O5/c1-3-7-27-26(18-20-10-12-21(13-11-20)24-8-5-6-9-25(24)28-35-32(41)43-36-28)29(39)37(31-33-19-34-38(27)31)23-16-14-22(15-17-23)30(40)42-4-2/h5-6,8-13,19,22-23H,3-4,7,14-18H2,1-2H3,(H,35,36,41)/t22-,23-
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107368
PNG
(US8592431, 169)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n([C@H]2CC[C@@H](CC2)c2nc(C)no2)c2ncnn12
Show InChI InChI=1S/C32H32N8O4/c1-3-6-27-26(17-20-9-11-21(12-10-20)24-7-4-5-8-25(24)28-36-32(42)44-38-28)30(41)39(31-33-18-34-40(27)31)23-15-13-22(14-16-23)29-35-19(2)37-43-29/h4-5,7-12,18,22-23H,3,6,13-17H2,1-2H3,(H,36,38,42)/t22-,23-
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107369
PNG
(US8592431, 170)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(C2CCC3(CC2)OCC(C)(C)CO3)c2ncnn12
Show InChI InChI=1S/C34H38N6O5/c1-4-7-28-27(18-22-10-12-23(13-11-22)25-8-5-6-9-26(25)29-37-32(42)45-38-29)30(41)39(31-35-21-36-40(28)31)24-14-16-34(17-15-24)43-19-33(2,3)20-44-34/h5-6,8-13,21,24H,4,7,14-20H2,1-3H3,(H,37,38,42)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107370
PNG
(US8592431, 173)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n([C@H]2CC[C@@H](CC2)c2nnc(C)o2)c2ncnn12
Show InChI InChI=1S/C32H32N8O4/c1-3-6-27-26(17-20-9-11-21(12-10-20)24-7-4-5-8-25(24)28-35-32(42)44-38-28)30(41)39(31-33-18-34-40(27)31)23-15-13-22(14-16-23)29-37-36-19(2)43-29/h4-5,7-12,18,22-23H,3,6,13-17H2,1-2H3,(H,35,38,42)/t22-,23-
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107372
PNG
(US8592431, 179)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(C2CCC3(CC2)OCC(C)(C)O3)c2ncnn12
Show InChI InChI=1S/C33H36N6O5/c1-4-7-27-26(18-21-10-12-22(13-11-21)24-8-5-6-9-25(24)28-36-31(41)43-37-28)29(40)38(30-34-20-35-39(27)30)23-14-16-33(17-15-23)42-19-32(2,3)44-33/h5-6,8-13,20,23H,4,7,14-19H2,1-3H3,(H,36,37,41)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107373
PNG
(US8592431, 180)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(C2CCC3(CC2)OC(C)(C)C(C)(C)O3)c2ncnn12
Show InChI InChI=1S/C35H40N6O5/c1-6-9-28-27(20-22-12-14-23(15-13-22)25-10-7-8-11-26(25)29-38-32(43)44-39-29)30(42)40(31-36-21-37-41(28)31)24-16-18-35(19-17-24)45-33(2,3)34(4,5)46-35/h7-8,10-15,21,24H,6,9,16-20H2,1-5H3,(H,38,39,43)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107374
PNG
(US8592431, 181)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c(=O)n(C2CCC3(CC2)OC(C)(C)C(C)(C)O3)c2ncnn12
Show InChI InChI=1S/C34H40N8O3/c1-6-9-28-27(20-22-12-14-23(15-13-22)25-10-7-8-11-26(25)29-37-39-40-38-29)30(43)41(31-35-21-36-42(28)31)24-16-18-34(19-17-24)44-32(2,3)33(4,5)45-34/h7-8,10-15,21,24H,6,9,16-20H2,1-5H3,(H,37,38,39,40)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107375
PNG
(US8592431, 183)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n([C@H]2CC[C@@](C)(CC2)OCCO)c2ncnn12
Show InChI InChI=1S/C32H36N6O5/c1-3-6-27-26(19-21-9-11-22(12-10-21)24-7-4-5-8-25(24)28-35-31(41)43-36-28)29(40)37(30-33-20-34-38(27)30)23-13-15-32(2,16-14-23)42-18-17-39/h4-5,7-12,20,23,39H,3,6,13-19H2,1-2H3,(H,35,36,41)/t23-,32-
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107376
PNG
(US8592431, 184)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n([C@H]2CC[C@@H](CC2)c2cnco2)c2ncnn12
Show InChI InChI=1S/C32H31N7O4/c1-2-5-27-26(16-20-8-10-21(11-9-20)24-6-3-4-7-25(24)29-36-32(41)43-37-29)30(40)38(31-34-18-35-39(27)31)23-14-12-22(13-15-23)28-17-33-19-42-28/h3-4,6-11,17-19,22-23H,2,5,12-16H2,1H3,(H,36,37,41)/t22-,23-
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107377
PNG
(US8592431, 185)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nnn[nH]2)c(=O)n([C@H]2CC[C@@H](CC2)c2cnco2)c2ncnn12
Show InChI InChI=1S/C31H31N9O2/c1-2-5-27-26(16-20-8-10-21(11-9-20)24-6-3-4-7-25(24)29-35-37-38-36-29)30(41)39(31-33-18-34-40(27)31)23-14-12-22(13-15-23)28-17-32-19-42-28/h3-4,6-11,17-19,22-23H,2,5,12-16H2,1H3,(H,35,36,37,38)/t22-,23-
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107378
PNG
(US8592431, 186)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n([C@H]2CC[C@@H](CC2)OCCCO)c2ncnn12
Show InChI InChI=1S/C32H36N6O5/c1-2-6-28-27(19-21-9-11-22(12-10-21)25-7-3-4-8-26(25)29-35-32(41)43-36-29)30(40)37(31-33-20-34-38(28)31)23-13-15-24(16-14-23)42-18-5-17-39/h3-4,7-12,20,23-24,39H,2,5-6,13-19H2,1H3,(H,35,36,41)/t23-,24-
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107379
PNG
(US8592431, 188)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(C2CCC(CC2)=NOC)c2ncnn12
Show InChI InChI=1S/C30H31N7O4/c1-3-6-26-25(28(38)36(29-31-18-32-37(26)29)22-15-13-21(14-16-22)34-40-2)17-19-9-11-20(12-10-19)23-7-4-5-8-24(23)27-33-30(39)41-35-27/h4-5,7-12,18,22H,3,6,13-17H2,1-2H3,(H,33,35,39)/b34-21-
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107380
PNG
(US8592431, 189)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n([C@H]2CC[C@](C)(CO)CC2)c2ncnn12
Show InChI InChI=1S/C31H34N6O4/c1-3-6-26-25(28(39)36(29-32-19-33-37(26)29)22-13-15-31(2,18-38)16-14-22)17-20-9-11-21(12-10-20)23-7-4-5-8-24(23)27-34-30(40)41-35-27/h4-5,7-12,19,22,38H,3,6,13-18H2,1-2H3,(H,34,35,40)/t22-,31-
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107381
PNG
(US8592431, 191)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(C2CCC(CC2)=CCO)c2ncnn12
Show InChI InChI=1S/C31H32N6O4/c1-2-5-27-26(29(39)36(30-32-19-33-37(27)30)23-14-10-20(11-15-23)16-17-38)18-21-8-12-22(13-9-21)24-6-3-4-7-25(24)28-34-31(40)41-35-28/h3-4,6-9,12-13,16,19,23,38H,2,5,10-11,14-15,17-18H2,1H3,(H,34,35,40)/b20-16-
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107382
PNG
(US8592431, 193)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(C2CCC(CC2)=NOC(C)C)c2ncnn12
Show InChI InChI=1S/C32H35N7O4/c1-4-7-28-27(18-21-10-12-22(13-11-21)25-8-5-6-9-26(25)29-35-32(41)43-37-29)30(40)38(31-33-19-34-39(28)31)24-16-14-23(15-17-24)36-42-20(2)3/h5-6,8-13,19-20,24H,4,7,14-18H2,1-3H3,(H,35,37,41)/b36-23-
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107383
PNG
(US8592431, 195)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n(C2CCC(CC2)=NOC2CCOCC2)c2ncnn12
Show InChI InChI=1S/C34H37N7O5/c1-2-5-30-29(20-22-8-10-23(11-9-22)27-6-3-4-7-28(27)31-37-34(43)46-39-31)32(42)40(33-35-21-36-41(30)33)25-14-12-24(13-15-25)38-45-26-16-18-44-19-17-26/h3-4,6-11,21,25-26H,2,5,12-20H2,1H3,(H,37,39,43)/b38-24-
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107384
PNG
(US8592431, 197)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n([C@H]2CC[C@@H](CC2)OCC(O)(CC)CC)c2nc(C)nn12
Show InChI InChI=1S/C36H44N6O5/c1-5-10-31-30(21-24-13-15-25(16-14-24)28-11-8-9-12-29(28)32-38-35(44)47-40-32)33(43)41(34-37-23(4)39-42(31)34)26-17-19-27(20-18-26)46-22-36(45,6-2)7-3/h8-9,11-16,26-27,45H,5-7,10,17-22H2,1-4H3,(H,38,40,44)/t26-,27-
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107385
PNG
(US8592431, 205)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n([C@H]2CC[C@@]3(CC(C)=NO3)CC2)c2ncnn12
Show InChI InChI=1S/C32H33N7O4/c1-3-6-27-26(17-21-9-11-22(12-10-21)24-7-4-5-8-25(24)28-35-31(41)42-37-28)29(40)38(30-33-19-34-39(27)30)23-13-15-32(16-14-23)18-20(2)36-43-32/h4-5,7-12,19,23H,3,6,13-18H2,1-2H3,(H,35,37,41)/t23-,32-
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107386
PNG
(US8592431, 204)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n([C@H]2CC[C@]3(CC(C)=NO3)CC2)c2ncnn12
Show InChI InChI=1S/C32H33N7O4/c1-3-6-27-26(17-21-9-11-22(12-10-21)24-7-4-5-8-25(24)28-35-31(41)42-37-28)29(40)38(30-33-19-34-39(27)30)23-13-15-32(16-14-23)18-20(2)36-43-32/h4-5,7-12,19,23H,3,6,13-18H2,1-2H3,(H,35,37,41)/t23-,32+
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107387
PNG
(US8592431, 206)
Show SMILES CCCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n([C@H]2CC[C@@H](CC2)OC(C)C(C)(C)O)c2ncnn12
Show InChI InChI=1S/C35H42N6O5/c1-5-6-11-30-29(20-23-12-14-24(15-13-23)27-9-7-8-10-28(27)31-38-34(43)46-39-31)32(42)40(33-36-21-37-41(30)33)25-16-18-26(19-17-25)45-22(2)35(3,4)44/h7-10,12-15,21-22,25-26,44H,5-6,11,16-20H2,1-4H3,(H,38,39,43)/t22?,25-,26-
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107388
PNG
(US8592431, 210)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n([C@H]2CC[C@@H](CC2)OCC#N)c2ncnn12
Show InChI InChI=1S/C31H31N7O4/c1-2-5-27-26(29(39)37(30-33-19-34-38(27)30)22-12-14-23(15-13-22)41-17-16-32)18-20-8-10-21(11-9-20)24-6-3-4-7-25(24)28-35-31(40)42-36-28/h3-4,6-11,19,22-23H,2,5,12-15,17-18H2,1H3,(H,35,36,40)/t22-,23-
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107389
PNG
(US8592431, 215)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n([C@H]2CC[C@@H](CC2)OCC(C)=O)c2ncnn12
Show InChI InChI=1S/C32H34N6O5/c1-3-6-28-27(17-21-9-11-22(12-10-21)25-7-4-5-8-26(25)29-35-32(41)43-36-29)30(40)37(31-33-19-34-38(28)31)23-13-15-24(16-14-23)42-18-20(2)39/h4-5,7-12,19,23-24H,3,6,13-18H2,1-2H3,(H,35,36,41)/t23-,24-
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107390
PNG
(US8592431, 216)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n([C@H]2CC[C@@H](CC2)OC\C(C)=N\OC)c2ncnn12
Show InChI InChI=1S/C33H37N7O5/c1-4-7-29-28(18-22-10-12-23(13-11-22)26-8-5-6-9-27(26)30-36-33(42)45-38-30)31(41)39(32-34-20-35-40(29)32)24-14-16-25(17-15-24)44-19-21(2)37-43-3/h5-6,8-13,20,24-25H,4,7,14-19H2,1-3H3,(H,36,38,42)/b37-21+/t24-,25-
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107391
PNG
(US8592431, 225)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n([C@H]2CC[C@@H](CC2)OCC(O)(CC)CC)c2ncnn12
Show InChI InChI=1S/C35H42N6O5/c1-4-9-30-29(20-23-12-14-24(15-13-23)27-10-7-8-11-28(27)31-38-34(43)46-39-31)32(42)40(33-36-22-37-41(30)33)25-16-18-26(19-17-25)45-21-35(44,5-2)6-3/h7-8,10-15,22,25-26,44H,4-6,9,16-21H2,1-3H3,(H,38,39,43)/t25-,26-
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107392
PNG
(US8592431, 227)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n([C@H]2CC[C@@H](CC2)OCC2(CCC2)C#N)c2ncnn12
Show InChI InChI=1S/C35H37N7O4/c1-2-6-30-29(19-23-9-11-24(12-10-23)27-7-3-4-8-28(27)31-39-34(44)46-40-31)32(43)41(33-37-22-38-42(30)33)25-13-15-26(16-14-25)45-21-35(20-36)17-5-18-35/h3-4,7-12,22,25-26H,2,5-6,13-19,21H2,1H3,(H,39,40,44)/t25-,26-
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
Acetyl-coenzyme A transporter 1 (AT1)


(Homo sapiens (Human))
BDBM107393
PNG
(US8592431, 228)
Show SMILES CCCc1c(Cc2ccc(cc2)-c2ccccc2-c2nc(=O)o[nH]2)c(=O)n([C@H]2CC[C@@H](CC2)OCC2(CO)CCC2)c2ncnn12
Show InChI InChI=1S/C35H40N6O5/c1-2-6-30-29(19-23-9-11-24(12-10-23)27-7-3-4-8-28(27)31-38-34(44)46-39-31)32(43)40(33-36-22-37-41(30)33)25-13-15-26(16-14-25)45-21-35(20-42)17-5-18-35/h3-4,7-12,22,25-26,42H,2,5-6,13-21H2,1H3,(H,38,39,44)/t25-,26-
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
The binding assay was performed using 22.5 pM [125I]-angiotensin II [manufactured by PerkinElmer, USA] (9 μg) in the presence of AT1 membrane an...


US Patent US8592431 (2013)


BindingDB Entry DOI: 10.7270/Q2H70DGX
More data for this
Ligand-Target Pair
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