BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 12 hits of ph data with Target = 'Alpha-L-fucosidase I'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50072586
PNG
(CHEMBL323048 | N-(3,4,5-Trihydroxy-6-methyl-tetrah...)
Show SMILES CC1OC(SCNC(C)=O)C(O)C(O)C1O
Show InChI InChI=1S/C9H17NO5S/c1-4-6(12)7(13)8(14)9(15-4)16-3-10-5(2)11/h4,6-9,12-14H,3H2,1-2H3,(H,10,11)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
3.90E+3n/an/an/an/an/an/a6.5n/a



University of Connecticut

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound was determined against alpha-L-fucosidase in human placenta at PH of 6.5; Mixed Inhibition type


Bioorg Med Chem Lett 8: 3265-8 (1999)


Article DOI: 10.1016/s0960-894x(98)00596-4
BindingDB Entry DOI: 10.7270/Q24J0D9C
More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50072586
PNG
(CHEMBL323048 | N-(3,4,5-Trihydroxy-6-methyl-tetrah...)
Show SMILES CC1OC(SCNC(C)=O)C(O)C(O)C1O
Show InChI InChI=1S/C9H17NO5S/c1-4-6(12)7(13)8(14)9(15-4)16-3-10-5(2)11/h4,6-9,12-14H,3H2,1-2H3,(H,10,11)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
4.60E+3n/an/an/an/an/an/a6.5n/a



University of Connecticut

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound was determined against alpha-L-fucosidase in bovine kidney at PH of 6.5; Mixed Inhibition type


Bioorg Med Chem Lett 8: 3265-8 (1999)


Article DOI: 10.1016/s0960-894x(98)00596-4
BindingDB Entry DOI: 10.7270/Q24J0D9C
More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50072586
PNG
(CHEMBL323048 | N-(3,4,5-Trihydroxy-6-methyl-tetrah...)
Show SMILES CC1OC(SCNC(C)=O)C(O)C(O)C1O
Show InChI InChI=1S/C9H17NO5S/c1-4-6(12)7(13)8(14)9(15-4)16-3-10-5(2)11/h4,6-9,12-14H,3H2,1-2H3,(H,10,11)
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
5.60E+3n/an/an/an/an/an/a6.5n/a



University of Connecticut

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound was determined against alpha-L-fucosidase in bovine epididymis at PH of 6.5; Competitive Inhibition type


Bioorg Med Chem Lett 8: 3265-8 (1999)


Article DOI: 10.1016/s0960-894x(98)00596-4
BindingDB Entry DOI: 10.7270/Q24J0D9C
More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50072585
PNG
(2-Aminomethylsulfanyl-6-methyl-tetrahydro-pyran-3,...)
Show SMILES CC1OC(SCN)C(O)C(O)C1O
Show InChI InChI=1S/C7H15NO4S/c1-3-4(9)5(10)6(11)7(12-3)13-2-8/h3-7,9-11H,2,8H2,1H3
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
5.90E+3n/an/an/an/an/an/a6.5n/a



University of Connecticut

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound was determined against alpha-L-fucosidase in bovine kidney at PH of 6.5; Mixed Inhibition type


Bioorg Med Chem Lett 8: 3265-8 (1999)


Article DOI: 10.1016/s0960-894x(98)00596-4
BindingDB Entry DOI: 10.7270/Q24J0D9C
More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50072585
PNG
(2-Aminomethylsulfanyl-6-methyl-tetrahydro-pyran-3,...)
Show SMILES CC1OC(SCN)C(O)C(O)C1O
Show InChI InChI=1S/C7H15NO4S/c1-3-4(9)5(10)6(11)7(12-3)13-2-8/h3-7,9-11H,2,8H2,1H3
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
6.10E+3n/an/an/an/an/an/a6.5n/a



University of Connecticut

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound was determined against alpha-L-fucosidase in human placenta at PH of 6.5; Mixed Inhibition type


Bioorg Med Chem Lett 8: 3265-8 (1999)


Article DOI: 10.1016/s0960-894x(98)00596-4
BindingDB Entry DOI: 10.7270/Q24J0D9C
More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50072585
PNG
(2-Aminomethylsulfanyl-6-methyl-tetrahydro-pyran-3,...)
Show SMILES CC1OC(SCN)C(O)C(O)C1O
Show InChI InChI=1S/C7H15NO4S/c1-3-4(9)5(10)6(11)7(12-3)13-2-8/h3-7,9-11H,2,8H2,1H3
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
6.80E+3n/an/an/an/an/an/a6.5n/a



University of Connecticut

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound was determined against alpha-L-fucosidase in bovine epididymis at PH of 6.5; Competitive Inhibition type


Bioorg Med Chem Lett 8: 3265-8 (1999)


Article DOI: 10.1016/s0960-894x(98)00596-4
BindingDB Entry DOI: 10.7270/Q24J0D9C
More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50104412
PNG
((S)-5-Methyl-piperidine-3,4-diol | CHEMBL86305)
Show SMILES CC1CNC[C@H](O)C1O
Show InChI InChI=1S/C6H13NO2/c1-4-2-7-3-5(8)6(4)9/h4-9H,2-3H2,1H3/t4?,5-,6?/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
8.40E+3n/an/an/an/an/an/a6.8n/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for inhibition of alpha-fucosidase from bovine kidney(sigma F 5884) at pH 6.8


Bioorg Med Chem Lett 6: 553-558 (1996)


Article DOI: 10.1016/0960-894X(96)00068-6
BindingDB Entry DOI: 10.7270/Q2ZS2WHG
More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50186733
PNG
(CHEMBL208152 | L-1,4,6-trideoxy-4,4-difluoronojiri...)
Show SMILES C[C@@H]1NC[C@@H](O)[C@H](O)C1(F)F
Show InChI InChI=1S/C6H11F2NO2/c1-3-6(7,8)5(11)4(10)2-9-3/h3-5,9-11H,2H2,1H3/t3-,4+,5-/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
2.50E+5n/an/an/an/an/an/a6.8n/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human placenta alpha fucosidase at pH 6.8


J Med Chem 49: 2989-97 (2006)


Article DOI: 10.1021/jm060066q
BindingDB Entry DOI: 10.7270/Q29P318F
More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50186735
PNG
(CHEMBL208021 | D-1,4-dideoxy-4,4-difluoromannonoji...)
Show SMILES OC[C@H]1NC[C@@H](O)[C@@H](O)C1(F)F
Show InChI InChI=1S/C6H11F2NO3/c7-6(8)4(2-10)9-1-3(11)5(6)12/h3-5,9-12H,1-2H2/t3-,4-,5-/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>1.00E+6n/an/an/an/an/an/a6.8n/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human placenta alpha fucosidase at pH 6.8


J Med Chem 49: 2989-97 (2006)


Article DOI: 10.1021/jm060066q
BindingDB Entry DOI: 10.7270/Q29P318F
More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50186732
PNG
(CHEMBL206628 | D-1,4,6-trideoxy-4,4-difluoronojiri...)
Show SMILES C[C@H]1NC[C@H](O)[C@@H](O)C1(F)F
Show InChI InChI=1S/C6H11F2NO2/c1-3-6(7,8)5(11)4(10)2-9-3/h3-5,9-11H,2H2,1H3/t3-,4+,5-/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>1.00E+6n/an/an/an/an/an/a6.8n/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human placenta alpha fucosidase at pH 6.8


J Med Chem 49: 2989-97 (2006)


Article DOI: 10.1021/jm060066q
BindingDB Entry DOI: 10.7270/Q29P318F
More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50186736
PNG
(CHEMBL380311 | L-1,4-dideoxy-4,4-difluorogulonojir...)
Show SMILES OC[C@@H]1NC[C@@H](O)[C@@H](O)C1(F)F
Show InChI InChI=1S/C6H11F2NO3/c7-6(8)4(2-10)9-1-3(11)5(6)12/h3-5,9-12H,1-2H2/t3-,4+,5-/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>1.00E+6n/an/an/an/an/an/a6.8n/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human placenta alpha fucosidase at pH 6.8


J Med Chem 49: 2989-97 (2006)


Article DOI: 10.1021/jm060066q
BindingDB Entry DOI: 10.7270/Q29P318F
More data for this
Ligand-Target Pair
Alpha-L-fucosidase I


(Homo sapiens)
BDBM50186734
PNG
(CHEMBL207910 | D-1,4-dideoxy-4,4-difluoronojirimyc...)
Show SMILES OC[C@H]1NC[C@H](O)[C@@H](O)C1(F)F
Show InChI InChI=1S/C6H11F2NO3/c7-6(8)4(2-10)9-1-3(11)5(6)12/h3-5,9-12H,1-2H2/t3-,4+,5+/m0/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
>1.00E+6n/an/an/an/an/an/a6.8n/a



Chinese Academy of Sciences

Curated by ChEMBL


Assay Description
Inhibition of human placenta alpha fucosidase at pH 6.8


J Med Chem 49: 2989-97 (2006)


Article DOI: 10.1021/jm060066q
BindingDB Entry DOI: 10.7270/Q29P318F
More data for this
Ligand-Target Pair