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Found 96 hits of ph data with Target = 'Amine oxidase [flavin-containing] B'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM11018
PNG
(2-[(E)-2-(3-chlorophenyl)ethenyl]-3,5,7-trimethyl-...)
Show SMILES CC1c2nc(\C=C\c3cccc(Cl)c3)n(C)c2C(=O)N(C)C1=O
Show InChI InChI=1S/C17H16ClN3O2/c1-10-14-15(17(23)21(3)16(10)22)20(2)13(19-14)8-7-11-5-4-6-12(18)9-11/h4-10H,1-3H3/b8-7+
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PubMed
100 -40.0n/an/an/an/an/a7.425



Emory University



Assay Description
MAO A and MAO B activities were determined spectrophotometrically. Competitive Ki values for both enzymes were determined by measuring initial rates ...


J Biol Chem 280: 15761-6 (2005)


Article DOI: 10.1074/jbc.M500949200
BindingDB Entry DOI: 10.7270/Q2DR2SP5
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM11021
PNG
((2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol |...)
Show SMILES CC(C)=CCC\C(C)=C\CC\C(C)=C\CO
Show InChI InChI=1S/C15H26O/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-16/h7,9,11,16H,5-6,8,10,12H2,1-4H3/b14-9+,15-11+
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PubMed
800 -34.8n/an/an/an/an/a7.425



Emory University



Assay Description
MAO A and MAO B activities were determined spectrophotometrically. Competitive Ki values for both enzymes were determined by measuring initial rates ...


J Biol Chem 280: 15761-6 (2005)


Article DOI: 10.1074/jbc.M500949200
BindingDB Entry DOI: 10.7270/Q2DR2SP5
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM11020
PNG
(1,4-diphenyl-2-butene (DPB) | [(2E)-4-phenylbut-2-...)
Show SMILES C(\C=C\Cc1ccccc1)c1ccccc1
Show InChI InChI=1S/C16H16/c1-3-9-15(10-4-1)13-7-8-14-16-11-5-2-6-12-16/h1-12H,13-14H2/b8-7+
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800 -34.8n/an/an/an/an/a7.425



Emory University



Assay Description
MAO A and MAO B activities were determined spectrophotometrically. Competitive Ki values for both enzymes were determined by measuring initial rates ...


J Biol Chem 280: 15761-6 (2005)


Article DOI: 10.1074/jbc.M500949200
BindingDB Entry DOI: 10.7270/Q2DR2SP5
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM123830
PNG
(4,5-dibromo-N'-(4-chlorobenzylidene)-1-methyl-...)
Show SMILES Cn1c(Br)c(Br)cc1C(=O)NN=Cc1ccc(Cl)cc1
Show InChI InChI=1S/C13H10Br2ClN3O/c1-19-11(6-10(14)12(19)15)13(20)18-17-7-8-2-4-9(16)5-3-8/h2-7H,1H3,(H,18,20)
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2.10E+3 -33.7n/an/an/an/an/a7.437



University of KwaZulu-Natal



Assay Description
The reaction mixtures (200 uL), containing recombinant human MAO-A or MAO-B (5 ug/mL) and the test compounds in potassium phosphate buffer (100 mM; p...


Chem Biol Drug Des 84: 593-602 (2014)


Article DOI: 10.1111/cbdd.12352
BindingDB Entry DOI: 10.7270/Q2RB738C
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM123832
PNG
(4,5-dibromo-N'-(4-methoxybenzylidene)-1-methyl...)
Show SMILES COc1ccc(C=NNC(=O)c2cc(Br)c(Br)n2C)cc1
Show InChI InChI=1S/C14H13Br2N3O2/c1-19-12(7-11(15)13(19)16)14(20)18-17-8-9-3-5-10(21-2)6-4-9/h3-8H,1-2H3,(H,18,20)
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2.90E+3 -32.9n/an/an/an/an/a7.437



University of KwaZulu-Natal



Assay Description
The reaction mixtures (200 uL), containing recombinant human MAO-A or MAO-B (5 ug/mL) and the test compounds in potassium phosphate buffer (100 mM; p...


Chem Biol Drug Des 84: 593-602 (2014)


Article DOI: 10.1111/cbdd.12352
BindingDB Entry DOI: 10.7270/Q2RB738C
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM123823
PNG
(4,5-dibromo-N'-[(2,4-dichlorophenyl)methyliden...)
Show SMILES Clc1ccc(C=NNC(=O)c2cc(Br)c(Br)[nH]2)c(Cl)c1
Show InChI InChI=1S/C12H7Br2Cl2N3O/c13-8-4-10(18-11(8)14)12(20)19-17-5-6-1-2-7(15)3-9(6)16/h1-5,18H,(H,19,20)/b17-5+
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3.10E+3 -32.7n/an/an/an/an/a7.437



University of KwaZulu-Natal



Assay Description
The reaction mixtures (200 uL), containing recombinant human MAO-A or MAO-B (5 ug/mL) and the test compounds in potassium phosphate buffer (100 mM; p...


Chem Biol Drug Des 84: 593-602 (2014)


Article DOI: 10.1111/cbdd.12352
BindingDB Entry DOI: 10.7270/Q2RB738C
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM123831
PNG
(4,5-dibromo-N'-(3,4-dimethoxybenzylidene)-1-me...)
Show SMILES COc1ccc(C=NNC(=O)c2cc(Br)c(Br)n2C)cc1OC
Show InChI InChI=1S/C15H15Br2N3O3/c1-20-11(7-10(16)14(20)17)15(21)19-18-8-9-4-5-12(22-2)13(6-9)23-3/h4-8H,1-3H3,(H,19,21)
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3.40E+3 -32.5n/an/an/an/an/a7.437



University of KwaZulu-Natal



Assay Description
The reaction mixtures (200 uL), containing recombinant human MAO-A or MAO-B (5 ug/mL) and the test compounds in potassium phosphate buffer (100 mM; p...


Chem Biol Drug Des 84: 593-602 (2014)


Article DOI: 10.1111/cbdd.12352
BindingDB Entry DOI: 10.7270/Q2RB738C
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM123828
PNG
(4,5-dibromo-N'-(2,6-dichlorobenzylidene)-1-met...)
Show SMILES Cn1c(Br)c(Br)cc1C(=O)NN=Cc1c(Cl)cccc1Cl
Show InChI InChI=1S/C13H9Br2Cl2N3O/c1-20-11(5-8(14)12(20)15)13(21)19-18-6-7-9(16)3-2-4-10(7)17/h2-6H,1H3,(H,19,21)
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3.90E+3 -32.1n/an/an/an/an/a7.437



University of KwaZulu-Natal



Assay Description
The reaction mixtures (200 uL), containing recombinant human MAO-A or MAO-B (5 ug/mL) and the test compounds in potassium phosphate buffer (100 mM; p...


Chem Biol Drug Des 84: 593-602 (2014)


Article DOI: 10.1111/cbdd.12352
BindingDB Entry DOI: 10.7270/Q2RB738C
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM123824
PNG
(4,5-dibromo-N'-(2-hydroxybenzylidene)-1-methyl...)
Show SMILES Cn1c(Br)c(Br)cc1C(=O)NN=Cc1ccccc1O
Show InChI InChI=1S/C13H11Br2N3O2/c1-18-10(6-9(14)12(18)15)13(20)17-16-7-8-4-2-3-5-11(8)19/h2-7,19H,1H3,(H,17,20)
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4.70E+3 -31.6n/an/an/an/an/a7.437



University of KwaZulu-Natal



Assay Description
The reaction mixtures (200 uL), containing recombinant human MAO-A or MAO-B (5 ug/mL) and the test compounds in potassium phosphate buffer (100 mM; p...


Chem Biol Drug Des 84: 593-602 (2014)


Article DOI: 10.1111/cbdd.12352
BindingDB Entry DOI: 10.7270/Q2RB738C
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM123818
PNG
(4,5-dibromo-N'-(2,6-dichlorobenzylidene)-1Hpyr...)
Show SMILES Clc1cccc(Cl)c1C=NNC(=O)c1cc(Br)c(Br)[nH]1
Show InChI InChI=1S/C12H7Br2Cl2N3O/c13-7-4-10(18-11(7)14)12(20)19-17-5-6-8(15)2-1-3-9(6)16/h1-5,18H,(H,19,20)/b17-5+
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5.20E+3 -31.4n/an/an/an/an/a7.437



University of KwaZulu-Natal



Assay Description
The reaction mixtures (200 uL), containing recombinant human MAO-A or MAO-B (5 ug/mL) and the test compounds in potassium phosphate buffer (100 mM; p...


Chem Biol Drug Des 84: 593-602 (2014)


Article DOI: 10.1111/cbdd.12352
BindingDB Entry DOI: 10.7270/Q2RB738C
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM123829
PNG
(4,5-dibromo-N'-(3,4-dihydroxybenzylidene)-1-me...)
Show SMILES Cn1c(Br)c(Br)cc1C(=O)NN=Cc1ccc(O)c(O)c1
Show InChI InChI=1S/C13H11Br2N3O3/c1-18-9(5-8(14)12(18)15)13(21)17-16-6-7-2-3-10(19)11(20)4-7/h2-6,19-20H,1H3,(H,17,21)
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6.10E+3 -31.0n/an/an/an/an/a7.437



University of KwaZulu-Natal



Assay Description
The reaction mixtures (200 uL), containing recombinant human MAO-A or MAO-B (5 ug/mL) and the test compounds in potassium phosphate buffer (100 mM; p...


Chem Biol Drug Des 84: 593-602 (2014)


Article DOI: 10.1111/cbdd.12352
BindingDB Entry DOI: 10.7270/Q2RB738C
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM123822
PNG
(4,5-dibromo-N'-(4-methoxybenzylidene)-1Hpyrrol...)
Show SMILES COc1ccc(C=NNC(=O)c2cc(Br)c(Br)[nH]2)cc1
Show InChI InChI=1S/C13H11Br2N3O2/c1-20-9-4-2-8(3-5-9)7-16-18-13(19)11-6-10(14)12(15)17-11/h2-7,17H,1H3,(H,18,19)/b16-7+
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6.55E+3 -30.8n/an/an/an/an/a7.437



University of KwaZulu-Natal



Assay Description
The reaction mixtures (200 uL), containing recombinant human MAO-A or MAO-B (5 ug/mL) and the test compounds in potassium phosphate buffer (100 mM; p...


Chem Biol Drug Des 84: 593-602 (2014)


Article DOI: 10.1111/cbdd.12352
BindingDB Entry DOI: 10.7270/Q2RB738C
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM123826
PNG
(4,5-dibromo-1-methyl-N'-(4-nitrobenzylidene)-1...)
Show SMILES Cn1c(Br)c(Br)cc1C(=O)NN=Cc1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C13H10Br2N4O3/c1-18-11(6-10(14)12(18)15)13(20)17-16-7-8-2-4-9(5-3-8)19(21)22/h2-7H,1H3,(H,17,20)
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6.90E+3 -30.6n/an/an/an/an/a7.437



University of KwaZulu-Natal



Assay Description
The reaction mixtures (200 uL), containing recombinant human MAO-A or MAO-B (5 ug/mL) and the test compounds in potassium phosphate buffer (100 mM; p...


Chem Biol Drug Des 84: 593-602 (2014)


Article DOI: 10.1111/cbdd.12352
BindingDB Entry DOI: 10.7270/Q2RB738C
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM123814
PNG
(4,5-dibromo-N'-(2-hydroxybenzylidene)-1H-pyrro...)
Show SMILES Oc1ccccc1C=NNC(=O)c1cc(Br)c(Br)[nH]1
Show InChI InChI=1S/C12H9Br2N3O2/c13-8-5-9(16-11(8)14)12(19)17-15-6-7-3-1-2-4-10(7)18/h1-6,16,18H,(H,17,19)/b15-6+
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8.90E+3 -30.0n/an/an/an/an/a7.437



University of KwaZulu-Natal



Assay Description
The reaction mixtures (200 uL), containing recombinant human MAO-A or MAO-B (5 ug/mL) and the test compounds in potassium phosphate buffer (100 mM; p...


Chem Biol Drug Des 84: 593-602 (2014)


Article DOI: 10.1111/cbdd.12352
BindingDB Entry DOI: 10.7270/Q2RB738C
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM123821
PNG
(4,5-dibromo-N'-(3,4-dimethoxybenzylidene)-1Hpy...)
Show SMILES COc1ccc(C=NNC(=O)c2cc(Br)c(Br)[nH]2)cc1OC
Show InChI InChI=1S/C14H13Br2N3O3/c1-21-11-4-3-8(5-12(11)22-2)7-17-19-14(20)10-6-9(15)13(16)18-10/h3-7,18H,1-2H3,(H,19,20)/b17-7+
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1.13E+4 -29.4n/an/an/an/an/a7.437



University of KwaZulu-Natal



Assay Description
The reaction mixtures (200 uL), containing recombinant human MAO-A or MAO-B (5 ug/mL) and the test compounds in potassium phosphate buffer (100 mM; p...


Chem Biol Drug Des 84: 593-602 (2014)


Article DOI: 10.1111/cbdd.12352
BindingDB Entry DOI: 10.7270/Q2RB738C
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM123820
PNG
(4,5-dibromo-N'-[(4-chlorophenyl)methylidene]-1...)
Show SMILES Clc1ccc(C=NNC(=O)c2cc(Br)c(Br)[nH]2)cc1
Show InChI InChI=1S/C12H8Br2ClN3O/c13-9-5-10(17-11(9)14)12(19)18-16-6-7-1-3-8(15)4-2-7/h1-6,17H,(H,18,19)/b16-6+
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1.25E+4 -29.1n/an/an/an/an/a7.437



University of KwaZulu-Natal



Assay Description
The reaction mixtures (200 uL), containing recombinant human MAO-A or MAO-B (5 ug/mL) and the test compounds in potassium phosphate buffer (100 mM; p...


Chem Biol Drug Des 84: 593-602 (2014)


Article DOI: 10.1111/cbdd.12352
BindingDB Entry DOI: 10.7270/Q2RB738C
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM123833
PNG
(4,5-dibromo-N'-(2,4-dichlorobenzylidene)-1-met...)
Show SMILES Cn1c(Br)c(Br)cc1C(=O)NN=Cc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C13H9Br2Cl2N3O/c1-20-11(5-9(14)12(20)15)13(21)19-18-6-7-2-3-8(16)4-10(7)17/h2-6H,1H3,(H,19,21)
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1.29E+4 -29.0n/an/an/an/an/a7.437



University of KwaZulu-Natal



Assay Description
The reaction mixtures (200 uL), containing recombinant human MAO-A or MAO-B (5 ug/mL) and the test compounds in potassium phosphate buffer (100 mM; p...


Chem Biol Drug Des 84: 593-602 (2014)


Article DOI: 10.1111/cbdd.12352
BindingDB Entry DOI: 10.7270/Q2RB738C
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM123827
PNG
(4,5-dibromo-N'-(4-hydroxybenzylidene)-1-methyl...)
Show SMILES Cn1c(Br)c(Br)cc1C(=O)NN=Cc1ccc(O)cc1
Show InChI InChI=1S/C13H11Br2N3O2/c1-18-11(6-10(14)12(18)15)13(20)17-16-7-8-2-4-9(19)5-3-8/h2-7,19H,1H3,(H,17,20)
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1.33E+4 -29.0n/an/an/an/an/a7.437



University of KwaZulu-Natal



Assay Description
The reaction mixtures (200 uL), containing recombinant human MAO-A or MAO-B (5 ug/mL) and the test compounds in potassium phosphate buffer (100 mM; p...


Chem Biol Drug Des 84: 593-602 (2014)


Article DOI: 10.1111/cbdd.12352
BindingDB Entry DOI: 10.7270/Q2RB738C
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM123816
PNG
(4,5-dibromo-N'-(4-nitrobenzylidene)-1H-pyrrole...)
Show SMILES [O-][N+](=O)c1ccc(C=NNC(=O)c2cc(Br)c(Br)[nH]2)cc1
Show InChI InChI=1S/C12H8Br2N4O3/c13-9-5-10(16-11(9)14)12(19)17-15-6-7-1-3-8(4-2-7)18(20)21/h1-6,16H,(H,17,19)/b15-6+
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1.44E+4 -28.7n/an/an/an/an/a7.437



University of KwaZulu-Natal



Assay Description
The reaction mixtures (200 uL), containing recombinant human MAO-A or MAO-B (5 ug/mL) and the test compounds in potassium phosphate buffer (100 mM; p...


Chem Biol Drug Des 84: 593-602 (2014)


Article DOI: 10.1111/cbdd.12352
BindingDB Entry DOI: 10.7270/Q2RB738C
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM123815
PNG
(4,5-dibromo-N'-(4-fluorobenzylidene)-1H-pyrrol...)
Show SMILES Fc1ccc(C=NNC(=O)c2cc(Br)c(Br)[nH]2)cc1
Show InChI InChI=1S/C12H8Br2FN3O/c13-9-5-10(17-11(9)14)12(19)18-16-6-7-1-3-8(15)4-2-7/h1-6,17H,(H,18,19)/b16-6+
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2.45E+4 -27.4n/an/an/an/an/a7.437



University of KwaZulu-Natal



Assay Description
The reaction mixtures (200 uL), containing recombinant human MAO-A or MAO-B (5 ug/mL) and the test compounds in potassium phosphate buffer (100 mM; p...


Chem Biol Drug Des 84: 593-602 (2014)


Article DOI: 10.1111/cbdd.12352
BindingDB Entry DOI: 10.7270/Q2RB738C
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM123825
PNG
(4,5-dibromo-N'-[(4-fluorophenyl)methylidene]-1...)
Show SMILES Cn1c(Br)c(Br)cc1C(=O)NN=Cc1ccc(F)cc1
Show InChI InChI=1S/C13H10Br2FN3O/c1-19-11(6-10(14)12(19)15)13(20)18-17-7-8-2-4-9(16)5-3-8/h2-7H,1H3,(H,18,20)
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3.81E+4 -26.2n/an/an/an/an/a7.437



University of KwaZulu-Natal



Assay Description
The reaction mixtures (200 uL), containing recombinant human MAO-A or MAO-B (5 ug/mL) and the test compounds in potassium phosphate buffer (100 mM; p...


Chem Biol Drug Des 84: 593-602 (2014)


Article DOI: 10.1111/cbdd.12352
BindingDB Entry DOI: 10.7270/Q2RB738C
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM123817
PNG
(4,5-dibromo-N'-(4-hydroxybenzylidene)-1H-pyrro...)
Show SMILES Oc1ccc(C=NNC(=O)c2cc(Br)c(Br)[nH]2)cc1
Show InChI InChI=1S/C12H9Br2N3O2/c13-9-5-10(16-11(9)14)12(19)17-15-6-7-1-3-8(18)4-2-7/h1-6,16,18H,(H,17,19)/b15-6+
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4.26E+4 -26.0n/an/an/an/an/a7.437



University of KwaZulu-Natal



Assay Description
The reaction mixtures (200 uL), containing recombinant human MAO-A or MAO-B (5 ug/mL) and the test compounds in potassium phosphate buffer (100 mM; p...


Chem Biol Drug Des 84: 593-602 (2014)


Article DOI: 10.1111/cbdd.12352
BindingDB Entry DOI: 10.7270/Q2RB738C
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM123819
PNG
(4,5-dibromo-N'-(3,4-dihydroxybenzylidene)-1Hpy...)
Show SMILES Oc1ccc(C=NNC(=O)c2cc(Br)c(Br)[nH]2)cc1O
Show InChI InChI=1S/C12H9Br2N3O3/c13-7-4-8(16-11(7)14)12(20)17-15-5-6-1-2-9(18)10(19)3-6/h1-5,16,18-19H,(H,17,20)/b15-5+
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4.48E+4 -25.8n/an/an/an/an/a7.437



University of KwaZulu-Natal



Assay Description
The reaction mixtures (200 uL), containing recombinant human MAO-A or MAO-B (5 ug/mL) and the test compounds in potassium phosphate buffer (100 mM; p...


Chem Biol Drug Des 84: 593-602 (2014)


Article DOI: 10.1111/cbdd.12352
BindingDB Entry DOI: 10.7270/Q2RB738C
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM29137
PNG
(substituted chalcone, 5a)
Show SMILES CC(C)=CCOc1ccc(C(=O)\C=C\c2ccccc2)c(O)c1
Show InChI InChI=1S/C20H20O3/c1-15(2)12-13-23-17-9-10-18(20(22)14-17)19(21)11-8-16-6-4-3-5-7-16/h3-12,14,22H,13H2,1-2H3/b11-8+
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n/an/a 1.88E+4n/an/an/an/a7.437



Universita degli Studi di Roma La Sapienza



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 2818-24 (2009)


Article DOI: 10.1021/jm801590u
BindingDB Entry DOI: 10.7270/Q2X63K8T
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM29138
PNG
(substituted chalcone, 5b)
Show SMILES CC(C)=CCOc1ccc(C(=O)\C=C\c2ccc(C)cc2)c(O)c1
Show InChI InChI=1S/C21H22O3/c1-15(2)12-13-24-18-9-10-19(21(23)14-18)20(22)11-8-17-6-4-16(3)5-7-17/h4-12,14,23H,13H2,1-3H3/b11-8+
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n/an/a 1.03E+3n/an/an/an/a7.437



Universita degli Studi di Roma La Sapienza



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 2818-24 (2009)


Article DOI: 10.1021/jm801590u
BindingDB Entry DOI: 10.7270/Q2X63K8T
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM29139
PNG
(substituted chalcone, 5e)
Show SMILES CC(C)=CCOc1ccc(C(=O)\C=C\c2ccc(Cl)cc2)c(O)c1
Show InChI InChI=1S/C20H19ClO3/c1-14(2)11-12-24-17-8-9-18(20(23)13-17)19(22)10-5-15-3-6-16(21)7-4-15/h3-11,13,23H,12H2,1-2H3/b10-5+
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n/an/a 1.25E+3n/an/an/an/a7.437



Universita degli Studi di Roma La Sapienza



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 2818-24 (2009)


Article DOI: 10.1021/jm801590u
BindingDB Entry DOI: 10.7270/Q2X63K8T
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM29140
PNG
(substituted chalcone, 5g)
Show SMILES COc1ccc(cc1)C(=O)\C=C\c1ccc(Cl)cc1
Show InChI InChI=1S/C16H13ClO2/c1-19-15-9-5-13(6-10-15)16(18)11-4-12-2-7-14(17)8-3-12/h2-11H,1H3/b11-4+
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n/an/a 54n/an/an/an/a7.437



Universita degli Studi di Roma La Sapienza



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 2818-24 (2009)


Article DOI: 10.1021/jm801590u
BindingDB Entry DOI: 10.7270/Q2X63K8T
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM29141
PNG
(substituted chalcone, 5h)
Show SMILES COc1ccc(cc1)C(=O)\C=C\c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C23H20O3/c1-25-21-14-10-20(11-15-21)23(24)16-9-18-7-12-22(13-8-18)26-17-19-5-3-2-4-6-19/h2-16H,17H2,1H3/b16-9+
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n/an/a 450n/an/an/an/a7.437



Universita degli Studi di Roma La Sapienza



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 2818-24 (2009)


Article DOI: 10.1021/jm801590u
BindingDB Entry DOI: 10.7270/Q2X63K8T
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM29142
PNG
(substituted chalcone, 5i)
Show SMILES COc1ccc(C(=O)\C=C\c2ccc(Cl)cc2)c(O)c1
Show InChI InChI=1S/C16H13ClO3/c1-20-13-7-8-14(16(19)10-13)15(18)9-4-11-2-5-12(17)6-3-11/h2-10,19H,1H3/b9-4+
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n/an/a 4.40n/an/an/an/a7.437



Universita degli Studi di Roma La Sapienza



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 2818-24 (2009)


Article DOI: 10.1021/jm801590u
BindingDB Entry DOI: 10.7270/Q2X63K8T
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM29143
PNG
(CHEMBL7976 | Chalcone 1 | Chalcone, 13 | cid_63776...)
Show SMILES O=C(\C=C\c1ccccc1)c1ccccc1
Show InChI InChI=1S/C15H12O/c16-15(14-9-5-2-6-10-14)12-11-13-7-3-1-4-8-13/h1-12H/b12-11+
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n/an/a 1.41E+3n/an/an/an/a7.437



Universita degli Studi di Roma La Sapienza



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 2818-24 (2009)


Article DOI: 10.1021/jm801590u
BindingDB Entry DOI: 10.7270/Q2X63K8T
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM29144
PNG
(substituted chalcone, 5k)
Show SMILES Oc1ccccc1C(=O)\C=C\c1ccc(Cl)cc1
Show InChI InChI=1S/C15H11ClO2/c16-12-8-5-11(6-9-12)7-10-15(18)13-3-1-2-4-14(13)17/h1-10,17H/b10-7+
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n/an/a 160n/an/an/an/a7.437



Universita degli Studi di Roma La Sapienza



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 2818-24 (2009)


Article DOI: 10.1021/jm801590u
BindingDB Entry DOI: 10.7270/Q2X63K8T
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM29145
PNG
(substituted chalcone, 5l)
Show SMILES Oc1ccc(cc1)C(=O)\C=C\c1ccc(Cl)cc1
Show InChI InChI=1S/C15H11ClO2/c16-13-6-1-11(2-7-13)3-10-15(18)12-4-8-14(17)9-5-12/h1-10,17H/b10-3+
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n/an/a 31n/an/an/an/a7.437



Universita degli Studi di Roma La Sapienza



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 2818-24 (2009)


Article DOI: 10.1021/jm801590u
BindingDB Entry DOI: 10.7270/Q2X63K8T
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM29134
PNG
(substituted chalcone, 5m)
Show SMILES Oc1ccc(C(=O)\C=C\c2ccc(Cl)cc2)c(O)c1
Show InChI InChI=1S/C15H11ClO3/c16-11-4-1-10(2-5-11)3-8-14(18)13-7-6-12(17)9-15(13)19/h1-9,17,19H/b8-3+
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n/an/a 5.10n/an/an/an/a7.437



Universita degli Studi di Roma La Sapienza



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 2818-24 (2009)


Article DOI: 10.1021/jm801590u
BindingDB Entry DOI: 10.7270/Q2X63K8T
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM29146
PNG
(substituted chalcone, 5n)
Show SMILES Oc1cc(F)ccc1C(=O)\C=C\c1ccc(Cl)cc1
Show InChI InChI=1S/C15H10ClFO2/c16-11-4-1-10(2-5-11)3-8-14(18)13-7-6-12(17)9-15(13)19/h1-9,19H/b8-3+
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n/an/a 71n/an/an/an/a7.437



Universita degli Studi di Roma La Sapienza



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 2818-24 (2009)


Article DOI: 10.1021/jm801590u
BindingDB Entry DOI: 10.7270/Q2X63K8T
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM29147
PNG
(substituted chalcone, 5o)
Show SMILES Fc1ccc(cc1)C(=O)\C=C\c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C22H17FO2/c23-20-11-9-19(10-12-20)22(24)15-8-17-6-13-21(14-7-17)25-16-18-4-2-1-3-5-18/h1-15H,16H2/b15-8+
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n/an/a 500n/an/an/an/a7.437



Universita degli Studi di Roma La Sapienza



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 2818-24 (2009)


Article DOI: 10.1021/jm801590u
BindingDB Entry DOI: 10.7270/Q2X63K8T
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM29148
PNG
(substituted chalcone, 5p)
Show SMILES CS(=O)(=O)c1ccc(cc1)C(=O)\C=C\c1ccc(Cl)cc1
Show InChI InChI=1S/C16H13ClO3S/c1-21(19,20)15-9-5-13(6-10-15)16(18)11-4-12-2-7-14(17)8-3-12/h2-11H,1H3/b11-4+
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n/an/a 470n/an/an/an/a7.437



Universita degli Studi di Roma La Sapienza



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 2818-24 (2009)


Article DOI: 10.1021/jm801590u
BindingDB Entry DOI: 10.7270/Q2X63K8T
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM15581
PNG
(CHEMBL8706 | CLG | CLORGILINE | Clorgyline | N-[3-...)
Show SMILES CN(CCCOc1ccc(Cl)cc1Cl)CC#C
Show InChI InChI=1S/C13H15Cl2NO/c1-3-7-16(2)8-4-9-17-13-6-5-11(14)10-12(13)15/h1,5-6,10H,4,7-9H2,2H3
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n/an/a 6.14E+4n/an/an/an/a7.437



Universita degli Studi di Roma La Sapienza



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 2818-24 (2009)


Article DOI: 10.1021/jm801590u
BindingDB Entry DOI: 10.7270/Q2X63K8T
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM15579
PNG
(CHEMBL972 | DEPRENYL | L-Deprenyl | N-methyl-N-[(2...)
Show SMILES C[C@H](Cc1ccccc1)N(C)CC#C
Show InChI InChI=1S/C13H17N/c1-4-10-14(3)12(2)11-13-8-6-5-7-9-13/h1,5-9,12H,10-11H2,2-3H3/t12-/m1/s1
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n/an/a 20n/an/an/an/a7.437



Universita degli Studi di Roma La Sapienza



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 2818-24 (2009)


Article DOI: 10.1021/jm801590u
BindingDB Entry DOI: 10.7270/Q2X63K8T
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM29136
PNG
(CHEMBL92401 | Euphozid | Iprazid | Iproniazid)
Show SMILES CC(C)NNC(=O)c1ccncc1
Show InChI InChI=1S/C9H13N3O/c1-7(2)11-12-9(13)8-3-5-10-6-4-8/h3-7,11H,1-2H3,(H,12,13)
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n/an/a 7.54E+3n/an/an/an/a7.437



Universita degli Studi di Roma La Sapienza



Assay Description
The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...


J Med Chem 52: 2818-24 (2009)


Article DOI: 10.1021/jm801590u
BindingDB Entry DOI: 10.7270/Q2X63K8T
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM86772
PNG
(Phthalonitrile analogue, 4a)
Show SMILES N#Cc1ccc(Oc2ccccc2)cc1C#N
Show InChI InChI=1S/C14H8N2O/c15-9-11-6-7-14(8-12(11)10-16)17-13-4-2-1-3-5-13/h1-8H
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n/an/a 6.02E+3n/an/an/an/a7.4-70



North-West University



Assay Description
MAO inhibition potencies of phthalonitrile, benzonitrile and benzyl phenyl ether analogs, recombinant human MAO-A and -B were employed as enzyme sour...


Bioorg Chem 40: 114-24 (2012)


Article DOI: 10.1016/j.bioorg.2011.10.003
BindingDB Entry DOI: 10.7270/Q2W66JB4
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM86773
PNG
(Phthalonitrile analogue, 4b)
Show SMILES N#Cc1ccc(OCc2ccccc2)cc1C#N
Show InChI InChI=1S/C15H10N2O/c16-9-13-6-7-15(8-14(13)10-17)18-11-12-4-2-1-3-5-12/h1-8H,11H2
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n/an/a 7.90n/an/an/an/a7.4-70



North-West University



Assay Description
MAO inhibition potencies of phthalonitrile, benzonitrile and benzyl phenyl ether analogs, recombinant human MAO-A and -B were employed as enzyme sour...


Bioorg Chem 40: 114-24 (2012)


Article DOI: 10.1016/j.bioorg.2011.10.003
BindingDB Entry DOI: 10.7270/Q2W66JB4
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM86774
PNG
(Phthalonitrile analogue, 4c)
Show SMILES N#Cc1ccc(OCCc2ccccc2)cc1C#N
Show InChI InChI=1S/C16H12N2O/c17-11-14-6-7-16(10-15(14)12-18)19-9-8-13-4-2-1-3-5-13/h1-7,10H,8-9H2
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n/an/a 18n/an/an/an/a7.4-70



North-West University



Assay Description
MAO inhibition potencies of phthalonitrile, benzonitrile and benzyl phenyl ether analogs, recombinant human MAO-A and -B were employed as enzyme sour...


Bioorg Chem 40: 114-24 (2012)


Article DOI: 10.1016/j.bioorg.2011.10.003
BindingDB Entry DOI: 10.7270/Q2W66JB4
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM86775
PNG
(Phthalonitrile analogue, 4d)
Show SMILES N#Cc1ccc(OCCCc2ccccc2)cc1C#N
Show InChI InChI=1S/C17H14N2O/c18-12-15-8-9-17(11-16(15)13-19)20-10-4-7-14-5-2-1-3-6-14/h1-3,5-6,8-9,11H,4,7,10H2
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n/an/a 136n/an/an/an/a7.4-70



North-West University



Assay Description
MAO inhibition potencies of phthalonitrile, benzonitrile and benzyl phenyl ether analogs, recombinant human MAO-A and -B were employed as enzyme sour...


Bioorg Chem 40: 114-24 (2012)


Article DOI: 10.1016/j.bioorg.2011.10.003
BindingDB Entry DOI: 10.7270/Q2W66JB4
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM86776
PNG
(Phthalonitrile analogue, 4e)
Show SMILES N#Cc1ccc(OC\C=C\c2ccccc2)cc1C#N
Show InChI InChI=1S/C17H12N2O/c18-12-15-8-9-17(11-16(15)13-19)20-10-4-7-14-5-2-1-3-6-14/h1-9,11H,10H2/b7-4+
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n/an/a 6.60n/an/an/an/a7.4-70



North-West University



Assay Description
MAO inhibition potencies of phthalonitrile, benzonitrile and benzyl phenyl ether analogs, recombinant human MAO-A and -B were employed as enzyme sour...


Bioorg Chem 40: 114-24 (2012)


Article DOI: 10.1016/j.bioorg.2011.10.003
BindingDB Entry DOI: 10.7270/Q2W66JB4
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM86777
PNG
(Phthalonitrile analogue, 4f)
Show SMILES N#Cc1ccc(Oc2ccc3ccccc3c2)cc1C#N
Show InChI InChI=1S/C18H10N2O/c19-11-15-6-8-18(10-16(15)12-20)21-17-7-5-13-3-1-2-4-14(13)9-17/h1-10H
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n/an/a 244n/an/an/an/a7.4-70



North-West University



Assay Description
MAO inhibition potencies of phthalonitrile, benzonitrile and benzyl phenyl ether analogs, recombinant human MAO-A and -B were employed as enzyme sour...


Bioorg Chem 40: 114-24 (2012)


Article DOI: 10.1016/j.bioorg.2011.10.003
BindingDB Entry DOI: 10.7270/Q2W66JB4
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM86778
PNG
(Phthalonitrile analogue, 4g)
Show SMILES Brc1ccc(Oc2ccc(C#N)c(c2)C#N)cc1
Show InChI InChI=1S/C14H7BrN2O/c15-12-2-5-13(6-3-12)18-14-4-1-10(8-16)11(7-14)9-17/h1-7H
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n/an/a 568n/an/an/an/a7.4-70



North-West University



Assay Description
MAO inhibition potencies of phthalonitrile, benzonitrile and benzyl phenyl ether analogs, recombinant human MAO-A and -B were employed as enzyme sour...


Bioorg Chem 40: 114-24 (2012)


Article DOI: 10.1016/j.bioorg.2011.10.003
BindingDB Entry DOI: 10.7270/Q2W66JB4
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM86779
PNG
(Phthalonitrile analogue, 4h)
Show SMILES Brc1ccc(COc2ccc(C#N)c(c2)C#N)cc1
Show InChI InChI=1S/C15H9BrN2O/c16-14-4-1-11(2-5-14)10-19-15-6-3-12(8-17)13(7-15)9-18/h1-7H,10H2
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n/an/a 4.80n/an/an/an/a7.4-70



North-West University



Assay Description
MAO inhibition potencies of phthalonitrile, benzonitrile and benzyl phenyl ether analogs, recombinant human MAO-A and -B were employed as enzyme sour...


Bioorg Chem 40: 114-24 (2012)


Article DOI: 10.1016/j.bioorg.2011.10.003
BindingDB Entry DOI: 10.7270/Q2W66JB4
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM86780
PNG
(Phthalonitrile analogue, 4i)
Show SMILES Brc1ccc(CCOc2ccc(C#N)c(c2)C#N)cc1
Show InChI InChI=1S/C16H11BrN2O/c17-15-4-1-12(2-5-15)7-8-20-16-6-3-13(10-18)14(9-16)11-19/h1-6,9H,7-8H2
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n/an/a 226n/an/an/an/a7.4-70



North-West University



Assay Description
MAO inhibition potencies of phthalonitrile, benzonitrile and benzyl phenyl ether analogs, recombinant human MAO-A and -B were employed as enzyme sour...


Bioorg Chem 40: 114-24 (2012)


Article DOI: 10.1016/j.bioorg.2011.10.003
BindingDB Entry DOI: 10.7270/Q2W66JB4
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM86781
PNG
(Benzonitrile analogue, 5a)
Show SMILES N#Cc1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C14H11NO/c15-10-12-6-8-14(9-7-12)16-11-13-4-2-1-3-5-13/h1-9H,11H2
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PubMed
n/an/a 785n/an/an/an/a7.4-70



North-West University



Assay Description
MAO inhibition potencies of phthalonitrile, benzonitrile and benzyl phenyl ether analogs, recombinant human MAO-A and -B were employed as enzyme sour...


Bioorg Chem 40: 114-24 (2012)


Article DOI: 10.1016/j.bioorg.2011.10.003
BindingDB Entry DOI: 10.7270/Q2W66JB4
More data for this
Ligand-Target Pair
Amine oxidase [flavin-containing] B


(Homo sapiens (Human))
BDBM86782
PNG
(Benzonitrile analogue, 5b)
Show SMILES N#Cc1cccc(OCc2ccccc2)c1
Show InChI InChI=1S/C14H11NO/c15-10-13-7-4-8-14(9-13)16-11-12-5-2-1-3-6-12/h1-9H,11H2
PDB

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PubMed
n/an/a 249n/an/an/an/a7.4-70



North-West University



Assay Description
MAO inhibition potencies of phthalonitrile, benzonitrile and benzyl phenyl ether analogs, recombinant human MAO-A and -B were employed as enzyme sour...


Bioorg Chem 40: 114-24 (2012)


Article DOI: 10.1016/j.bioorg.2011.10.003
BindingDB Entry DOI: 10.7270/Q2W66JB4
More data for this
Ligand-Target Pair
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