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Compile Data Set for Download or QSAR

Found 236 hits of ph data with Target = 'Anandamide amidohydrolase'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM237306
PNG
(3-Methylpyridin-2-yl 2-(4-isobutylphenyl)propanoat...)
Show SMILES CC(C)Cc1ccc(cc1)C(C)C(=O)Oc1ncccc1C
Show InChI InChI=1S/C19H23NO2/c1-13(2)12-16-7-9-17(10-8-16)15(4)19(21)22-18-14(3)6-5-11-20-18/h5-11,13,15H,12H2,1-4H3
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n/an/a 1.15E+5n/an/an/an/a7.04



Umeň University



Assay Description
Frozen (−80┬░C) brains (minus cerebella) from adult Wistar or Sprague-Dawley rats were thawed and homogenized in 20 mM HEPES, 1 mM MgCl2, pH 7....


J Enzyme Inhib Med Chem 28: 172-82 (2013)


Article DOI: 10.3109/14756366.2011.643304
BindingDB Entry DOI: 10.7270/Q2BG2MWD
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50009859
PNG
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Show SMILES CC(C)Cc1ccc(cc1)C(C)C(O)=O
Show InChI InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)
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n/an/a 1.34E+5n/an/an/an/a7.04



Umeň University



Assay Description
Frozen (−80┬░C) brains (minus cerebella) from adult Wistar or Sprague-Dawley rats were thawed and homogenized in 20 mM HEPES, 1 mM MgCl2, pH 7....


J Enzyme Inhib Med Chem 28: 172-82 (2013)


Article DOI: 10.3109/14756366.2011.643304
BindingDB Entry DOI: 10.7270/Q2BG2MWD
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50009859
PNG
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Show SMILES CC(C)Cc1ccc(cc1)C(C)C(O)=O
Show InChI InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)
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n/an/a 1.63E+5n/an/an/an/a7.04



Umeň University



Assay Description
Frozen (−80┬░C) brains (minus cerebella) from adult Wistar or Sprague-Dawley rats were thawed and homogenized in 20 mM HEPES, 1 mM MgCl2, pH 7....


J Enzyme Inhib Med Chem 28: 172-82 (2013)


Article DOI: 10.3109/14756366.2011.643304
BindingDB Entry DOI: 10.7270/Q2BG2MWD
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50307794
PNG
(2-(4-isobutylphenyl)-N-(3-methylpyridin-2-yl)propa...)
Show SMILES CC(C)Cc1ccc(cc1)C(C)C(=O)Nc1ncccc1C
Show InChI InChI=1S/C19H24N2O/c1-13(2)12-16-7-9-17(10-8-16)15(4)19(22)21-18-14(3)6-5-11-20-18/h5-11,13,15H,12H2,1-4H3,(H,20,21,22)
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n/an/a 520n/an/an/an/a7.04



Umeň University



Assay Description
Frozen (−80┬░C) brains (minus cerebella) from adult Wistar or Sprague-Dawley rats were thawed and homogenized in 20 mM HEPES, 1 mM MgCl2, pH 7....


J Enzyme Inhib Med Chem 28: 172-82 (2013)


Article DOI: 10.3109/14756366.2011.643304
BindingDB Entry DOI: 10.7270/Q2BG2MWD
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50307794
PNG
(2-(4-isobutylphenyl)-N-(3-methylpyridin-2-yl)propa...)
Show SMILES CC(C)Cc1ccc(cc1)C(C)C(=O)Nc1ncccc1C
Show InChI InChI=1S/C19H24N2O/c1-13(2)12-16-7-9-17(10-8-16)15(4)19(22)21-18-14(3)6-5-11-20-18/h5-11,13,15H,12H2,1-4H3,(H,20,21,22)
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n/an/a 650n/an/an/an/a7.04



Umeň University



Assay Description
Frozen (−80┬░C) brains (minus cerebella) from adult Wistar or Sprague-Dawley rats were thawed and homogenized in 20 mM HEPES, 1 mM MgCl2, pH 7....


J Enzyme Inhib Med Chem 28: 172-82 (2013)


Article DOI: 10.3109/14756366.2011.643304
BindingDB Entry DOI: 10.7270/Q2BG2MWD
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM237312
PNG
(2-(4-Isobutylphenyl)-N-(2-oxo-2-(pyridin-3-ylmethy...)
Show SMILES CC(C)Cc1ccc(cc1)C(C)C(=O)NCC(=O)NCc1cccnc1
Show InChI InChI=1S/C21H27N3O2/c1-15(2)11-17-6-8-19(9-7-17)16(3)21(26)24-14-20(25)23-13-18-5-4-10-22-12-18/h4-10,12,15-16H,11,13-14H2,1-3H3,(H,23,25)(H,24,26)
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n/an/a 3.70E+4n/an/an/an/a7.04



Umeň University



Assay Description
Frozen (−80┬░C) brains (minus cerebella) from adult Wistar or Sprague-Dawley rats were thawed and homogenized in 20 mM HEPES, 1 mM MgCl2, pH 7....


J Enzyme Inhib Med Chem 28: 172-82 (2013)


Article DOI: 10.3109/14756366.2011.643304
BindingDB Entry DOI: 10.7270/Q2BG2MWD
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM237307
PNG
(4-Acetamidophenyl 2-(2-(4-isobutylphenyl)propanami...)
Show SMILES CC(C)Cc1ccc(cc1)C(C)C(=O)NCC(=O)Oc1ccc(NC(C)=O)cc1
Show InChI InChI=1S/C23H28N2O4/c1-15(2)13-18-5-7-19(8-6-18)16(3)23(28)24-14-22(27)29-21-11-9-20(10-12-21)25-17(4)26/h5-12,15-16H,13-14H2,1-4H3,(H,24,28)(H,25,26)
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n/an/a 1.50E+3n/an/an/an/a7.04



Umeň University



Assay Description
Frozen (−80┬░C) brains (minus cerebella) from adult Wistar or Sprague-Dawley rats were thawed and homogenized in 20 mM HEPES, 1 mM MgCl2, pH 7....


J Enzyme Inhib Med Chem 28: 172-82 (2013)


Article DOI: 10.3109/14756366.2011.643304
BindingDB Entry DOI: 10.7270/Q2BG2MWD
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM237308
PNG
(ibu-am14 (9))
Show SMILES CC(C)Cc1ccc(cc1)C(C)C(=O)NCC(=O)Nc1ncccc1C
Show InChI InChI=1S/C21H27N3O2/c1-14(2)12-17-7-9-18(10-8-17)16(4)21(26)23-13-19(25)24-20-15(3)6-5-11-22-20/h5-11,14,16H,12-13H2,1-4H3,(H,23,26)(H,22,24,25)
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n/an/a 3.60E+3n/an/an/an/a7.04



Umeň University



Assay Description
Frozen (−80┬░C) brains (minus cerebella) from adult Wistar or Sprague-Dawley rats were thawed and homogenized in 20 mM HEPES, 1 mM MgCl2, pH 7....


J Enzyme Inhib Med Chem 28: 172-82 (2013)


Article DOI: 10.3109/14756366.2011.643304
BindingDB Entry DOI: 10.7270/Q2BG2MWD
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM237309
PNG
(2-(4-Isobutylphenyl)-N-(2-(6-methylpyridin-2-ylami...)
Show SMILES CC(C)Cc1ccc(cc1)C(C)C(=O)NCC(=O)Nc1cccc(C)n1
Show InChI InChI=1S/C21H27N3O2/c1-14(2)12-17-8-10-18(11-9-17)16(4)21(26)22-13-20(25)24-19-7-5-6-15(3)23-19/h5-11,14,16H,12-13H2,1-4H3,(H,22,26)(H,23,24,25)
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n/an/a 1.50E+5n/an/an/an/a7.04



Umeň University



Assay Description
Frozen (−80┬░C) brains (minus cerebella) from adult Wistar or Sprague-Dawley rats were thawed and homogenized in 20 mM HEPES, 1 mM MgCl2, pH 7....


J Enzyme Inhib Med Chem 28: 172-82 (2013)


Article DOI: 10.3109/14756366.2011.643304
BindingDB Entry DOI: 10.7270/Q2BG2MWD
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM237310
PNG
(2-(4-Isobutylphenyl)-N-(3-(3-methylpyridin-2-ylami...)
Show SMILES CC(C)Cc1ccc(cc1)C(C)C(=O)NCCC(=O)Nc1ncccc1C
Show InChI InChI=1S/C22H29N3O2/c1-15(2)14-18-7-9-19(10-8-18)17(4)22(27)24-13-11-20(26)25-21-16(3)6-5-12-23-21/h5-10,12,15,17H,11,13-14H2,1-4H3,(H,24,27)(H,23,25,26)
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n/an/a 9.30E+3n/an/an/an/a7.04



Umeň University



Assay Description
Frozen (−80┬░C) brains (minus cerebella) from adult Wistar or Sprague-Dawley rats were thawed and homogenized in 20 mM HEPES, 1 mM MgCl2, pH 7....


J Enzyme Inhib Med Chem 28: 172-82 (2013)


Article DOI: 10.3109/14756366.2011.643304
BindingDB Entry DOI: 10.7270/Q2BG2MWD
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM237311
PNG
(2-(4-Isobutylphenyl)-N-(2-oxo-2-(pyridin-2- ylmeth...)
Show SMILES CC(C)Cc1ccc(cc1)C(C)C(=O)NCC(=O)NCc1ccccn1
Show InChI InChI=1S/C21H27N3O2/c1-15(2)12-17-7-9-18(10-8-17)16(3)21(26)24-14-20(25)23-13-19-6-4-5-11-22-19/h4-11,15-16H,12-14H2,1-3H3,(H,23,25)(H,24,26)
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n/an/a 9.00E+4n/an/an/an/a7.04



Umeň University



Assay Description
Frozen (−80┬░C) brains (minus cerebella) from adult Wistar or Sprague-Dawley rats were thawed and homogenized in 20 mM HEPES, 1 mM MgCl2, pH 7....


J Enzyme Inhib Med Chem 28: 172-82 (2013)


Article DOI: 10.3109/14756366.2011.643304
BindingDB Entry DOI: 10.7270/Q2BG2MWD
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50204516
PNG
(6-(2-(7-phenylheptanoyl)oxazol-5-yl)picolinic acid...)
Show SMILES OC(=O)c1cccc(n1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1
Show InChI InChI=1S/C22H22N2O4/c25-19(14-7-2-1-4-9-16-10-5-3-6-11-16)21-23-15-20(28-21)17-12-8-13-18(24-17)22(26)27/h3,5-6,8,10-13,15H,1-2,4,7,9,14H2,(H,26,27)
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10.3n/an/an/an/an/an/a7.4n/a



Institute for Chemical Biology

Curated by ChEMBL


Assay Description
Inhibition of rat FAAH expressed in Escherichia coli at pH 7.4


J Med Chem 51: 4392-403 (2008)


Article DOI: 10.1021/jm800136b
BindingDB Entry DOI: 10.7270/Q26D5TW3
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM143301
PNG
(US9682953, 5.A-2)
Show SMILES FC(F)(F)c1ccc(Oc2cccc(C=C3CCC(CC3)NC(=O)c3ccc(nc3)N3CCCC3)c2)nc1
Show InChI InChI=1S/C29H29F3N4O2/c30-29(31,32)23-9-13-27(34-19-23)38-25-5-3-4-21(17-25)16-20-6-10-24(11-7-20)35-28(37)22-8-12-26(33-18-22)36-14-1-2-15-36/h3-5,8-9,12-13,16-19,24H,1-2,6-7,10-11,14-15H2,(H,35,37)/b20-16-
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n/an/a 28n/an/an/an/a7.425



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
All reagents were purchased from Sigma-Aldrich unless specified. Human and Rat Fatty Acid Amide Hydrolase (FAAH) genes used in assay have been descri...


US Patent US9682953 (2017)


BindingDB Entry DOI: 10.7270/Q2BR8QBH
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM143302
PNG
(US9682953, 5.A-6)
Show SMILES FC(F)(F)S(=O)(=O)c1ccc(Oc2cccc(C=C3CCC(CC3)NC(=O)c3ccc(nc3)-n3cccn3)c2)nc1
Show InChI InChI=1S/C28H24F3N5O4S/c29-28(30,31)41(38,39)24-10-12-26(33-18-24)40-23-4-1-3-20(16-23)15-19-5-8-22(9-6-19)35-27(37)21-7-11-25(32-17-21)36-14-2-13-34-36/h1-4,7,10-18,22H,5-6,8-9H2,(H,35,37)/b19-15-
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n/an/a 7n/an/an/an/a7.425



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
All reagents were purchased from Sigma-Aldrich unless specified. Human and Rat Fatty Acid Amide Hydrolase (FAAH) genes used in assay have been descri...


US Patent US9682953 (2017)


BindingDB Entry DOI: 10.7270/Q2BR8QBH
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM143257
PNG
(US9682953, 2.B-4)
Show SMILES FC(F)(F)c1ccc(Oc2cccc(C=C3CCC(CC3)NC(=O)c3ccc(nc3)-c3cc[nH]n3)c2)nc1
Show InChI InChI=1S/C28H24F3N5O2/c29-28(30,31)21-7-11-26(33-17-21)38-23-3-1-2-19(15-23)14-18-4-8-22(9-5-18)35-27(37)20-6-10-24(32-16-20)25-12-13-34-36-25/h1-3,6-7,10-17,22H,4-5,8-9H2,(H,34,36)(H,35,37)/b18-14-
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n/an/a 11n/an/an/an/a7.425



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
All reagents were purchased from Sigma-Aldrich unless specified. Human and Rat Fatty Acid Amide Hydrolase (FAAH) genes used in assay have been descri...


US Patent US9682953 (2017)


BindingDB Entry DOI: 10.7270/Q2BR8QBH
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM143258
PNG
(US9682953, 2.B-5)
Show SMILES FC(F)(F)c1ccc(Oc2cccc(C=C3CCC(CC3)NC(=O)c3ccc(nc3)-c3cn[nH]c3)c2)nc1
Show InChI InChI=1S/C28H24F3N5O2/c29-28(30,31)22-7-11-26(33-17-22)38-24-3-1-2-19(13-24)12-18-4-8-23(9-5-18)36-27(37)20-6-10-25(32-14-20)21-15-34-35-16-21/h1-3,6-7,10-17,23H,4-5,8-9H2,(H,34,35)(H,36,37)/b18-12-
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n/an/a 9n/an/an/an/a7.425



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
All reagents were purchased from Sigma-Aldrich unless specified. Human and Rat Fatty Acid Amide Hydrolase (FAAH) genes used in assay have been descri...


US Patent US9682953 (2017)


BindingDB Entry DOI: 10.7270/Q2BR8QBH
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM143259
PNG
(US9682953, 2.B-6)
Show SMILES Cc1cnn(c1)-c1ccc(cn1)C(=O)NC1CCC(CC1)=Cc1cccc(Oc2ccc(cn2)C(F)(F)F)c1
Show InChI InChI=1S/C29H26F3N5O2/c1-19-15-35-37(18-19)26-11-7-22(16-33-26)28(38)36-24-9-5-20(6-10-24)13-21-3-2-4-25(14-21)39-27-12-8-23(17-34-27)29(30,31)32/h2-4,7-8,11-18,24H,5-6,9-10H2,1H3,(H,36,38)/b20-13-
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n/an/a 21n/an/an/an/a7.425



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
All reagents were purchased from Sigma-Aldrich unless specified. Human and Rat Fatty Acid Amide Hydrolase (FAAH) genes used in assay have been descri...


US Patent US9682953 (2017)


BindingDB Entry DOI: 10.7270/Q2BR8QBH
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM143263
PNG
(US9682953, 2.B-9)
Show SMILES Cc1ccn(n1)-c1ccc(cn1)C(=O)NC1CCC(CC1)=Cc1cccc(Oc2ccc(cn2)C(F)(F)F)c1
Show InChI InChI=1S/C29H26F3N5O2/c1-19-13-14-37(36-19)26-11-7-22(17-33-26)28(38)35-24-9-5-20(6-10-24)15-21-3-2-4-25(16-21)39-27-12-8-23(18-34-27)29(30,31)32/h2-4,7-8,11-18,24H,5-6,9-10H2,1H3,(H,35,38)/b20-15-
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n/an/a 22n/an/an/an/a7.425



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
All reagents were purchased from Sigma-Aldrich unless specified. Human and Rat Fatty Acid Amide Hydrolase (FAAH) genes used in assay have been descri...


US Patent US9682953 (2017)


BindingDB Entry DOI: 10.7270/Q2BR8QBH
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM143261
PNG
(US9682953, 2.B-8)
Show SMILES FC(F)(F)c1ccc(Oc2cccc(C=C3CCC(CC3)NC(=O)c3ccc(nc3)-n3cc(Cl)cn3)c2)nc1
Show InChI InChI=1S/C28H23ClF3N5O2/c29-22-16-35-37(17-22)25-10-6-20(14-33-25)27(38)36-23-8-4-18(5-9-23)12-19-2-1-3-24(13-19)39-26-11-7-21(15-34-26)28(30,31)32/h1-3,6-7,10-17,23H,4-5,8-9H2,(H,36,38)/b18-12-
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n/an/a 21n/an/an/an/a7.425



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
All reagents were purchased from Sigma-Aldrich unless specified. Human and Rat Fatty Acid Amide Hydrolase (FAAH) genes used in assay have been descri...


US Patent US9682953 (2017)


BindingDB Entry DOI: 10.7270/Q2BR8QBH
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM143260
PNG
(US9682953, 2.B-7)
Show SMILES FC(F)(F)c1ccc(Oc2cccc(C=C3CCC(CC3)NC(=O)c3cncc(c3)-n3cccn3)c2)nc1
Show InChI InChI=1S/C28H24F3N5O2/c29-28(30,31)22-7-10-26(33-17-22)38-25-4-1-3-20(14-25)13-19-5-8-23(9-6-19)35-27(37)21-15-24(18-32-16-21)36-12-2-11-34-36/h1-4,7,10-18,23H,5-6,8-9H2,(H,35,37)/b19-13-
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n/an/a 85n/an/an/an/a7.425



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
All reagents were purchased from Sigma-Aldrich unless specified. Human and Rat Fatty Acid Amide Hydrolase (FAAH) genes used in assay have been descri...


US Patent US9682953 (2017)


BindingDB Entry DOI: 10.7270/Q2BR8QBH
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM143264
PNG
(US9682953, 2.B-11)
Show SMILES Cc1n[nH]c(C)c1-c1ccc(cn1)C(=O)NC1CCC(CC1)=Cc1cccc(Oc2ccc(cn2)C(F)(F)F)c1
Show InChI InChI=1S/C30H28F3N5O2/c1-18-28(19(2)38-37-18)26-12-8-22(16-34-26)29(39)36-24-10-6-20(7-11-24)14-21-4-3-5-25(15-21)40-27-13-9-23(17-35-27)30(31,32)33/h3-5,8-9,12-17,24H,6-7,10-11H2,1-2H3,(H,36,39)(H,37,38)/b20-14-
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n/an/a 52n/an/an/an/a7.425



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
All reagents were purchased from Sigma-Aldrich unless specified. Human and Rat Fatty Acid Amide Hydrolase (FAAH) genes used in assay have been descri...


US Patent US9682953 (2017)


BindingDB Entry DOI: 10.7270/Q2BR8QBH
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM143265
PNG
(US9682953, 2.B-13)
Show SMILES FC(F)(F)c1ccc(Oc2cccc(C=C3CCC(CC3)NC(=O)c3ccc(nc3)-n3cnnc3)c2)nc1
Show InChI InChI=1S/C27H23F3N6O2/c28-27(29,30)21-7-11-25(32-15-21)38-23-3-1-2-19(13-23)12-18-4-8-22(9-5-18)35-26(37)20-6-10-24(31-14-20)36-16-33-34-17-36/h1-3,6-7,10-17,22H,4-5,8-9H2,(H,35,37)/b18-12-
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n/an/a 14n/an/an/an/a7.425



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
All reagents were purchased from Sigma-Aldrich unless specified. Human and Rat Fatty Acid Amide Hydrolase (FAAH) genes used in assay have been descri...


US Patent US9682953 (2017)


BindingDB Entry DOI: 10.7270/Q2BR8QBH
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM143266
PNG
(US9682953, 2.B-14)
Show SMILES FC(F)(F)c1ccc(Oc2cccc(C=C3CCC(CC3)NC(=O)c3ccc(nc3)-n3ccnn3)c2)nc1
Show InChI InChI=1S/C27H23F3N6O2/c28-27(29,30)21-7-11-25(32-17-21)38-23-3-1-2-19(15-23)14-18-4-8-22(9-5-18)34-26(37)20-6-10-24(31-16-20)36-13-12-33-35-36/h1-3,6-7,10-17,22H,4-5,8-9H2,(H,34,37)/b18-14-
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n/an/a 11n/an/an/an/a7.425



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
All reagents were purchased from Sigma-Aldrich unless specified. Human and Rat Fatty Acid Amide Hydrolase (FAAH) genes used in assay have been descri...


US Patent US9682953 (2017)


BindingDB Entry DOI: 10.7270/Q2BR8QBH
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM143267
PNG
(US9682953, 2.B-15)
Show SMILES FC(F)(F)c1ccc(Oc2cccc(C=C3CCC(CC3)NC(=O)c3ccc(nc3)-n3nccn3)c2)nc1
Show InChI InChI=1S/C27H23F3N6O2/c28-27(29,30)21-7-11-25(32-17-21)38-23-3-1-2-19(15-23)14-18-4-8-22(9-5-18)35-26(37)20-6-10-24(31-16-20)36-33-12-13-34-36/h1-3,6-7,10-17,22H,4-5,8-9H2,(H,35,37)/b18-14-
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n/an/a 9n/an/an/an/a7.425



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
All reagents were purchased from Sigma-Aldrich unless specified. Human and Rat Fatty Acid Amide Hydrolase (FAAH) genes used in assay have been descri...


US Patent US9682953 (2017)


BindingDB Entry DOI: 10.7270/Q2BR8QBH
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM143229
PNG
(US9682953, 2.A-23)
Show SMILES Cc1[nH]ncc1C(=O)NC1CCC(CC1)=Cc1cccc(Oc2ccc(cn2)C(F)(F)F)c1
Show InChI InChI=1S/C24H23F3N4O2/c1-15-21(14-29-31-15)23(32)30-19-8-5-16(6-9-19)11-17-3-2-4-20(12-17)33-22-10-7-18(13-28-22)24(25,26)27/h2-4,7,10-14,19H,5-6,8-9H2,1H3,(H,29,31)(H,30,32)/b16-11-
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n/an/a 29n/an/an/an/a7.425



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
All reagents were purchased from Sigma-Aldrich unless specified. Human and Rat Fatty Acid Amide Hydrolase (FAAH) genes used in assay have been descri...


US Patent US9682953 (2017)


BindingDB Entry DOI: 10.7270/Q2BR8QBH
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM143239
PNG
(US9682953, 2.A-29)
Show SMILES FC(F)(F)c1n[nH]cc1C(=O)NC1CCC(CC1)=Cc1cccc(Oc2ccc(cn2)C(F)(F)F)c1
Show InChI InChI=1S/C24H20F6N4O2/c25-23(26,27)16-6-9-20(31-12-16)36-18-3-1-2-15(11-18)10-14-4-7-17(8-5-14)33-22(35)19-13-32-34-21(19)24(28,29)30/h1-3,6,9-13,17H,4-5,7-8H2,(H,32,34)(H,33,35)/b14-10-
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n/an/a 24n/an/an/an/a7.425



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
All reagents were purchased from Sigma-Aldrich unless specified. Human and Rat Fatty Acid Amide Hydrolase (FAAH) genes used in assay have been descri...


US Patent US9682953 (2017)


BindingDB Entry DOI: 10.7270/Q2BR8QBH
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM143250
PNG
(US9682953, 2.A-39)
Show SMILES CC(C)c1[nH]ncc1C(=O)NC1CCC(CC1)=Cc1cccc(Oc2ccc(cn2)C(F)(F)F)c1
Show InChI InChI=1S/C26H27F3N4O2/c1-16(2)24-22(15-31-33-24)25(34)32-20-9-6-17(7-10-20)12-18-4-3-5-21(13-18)35-23-11-8-19(14-30-23)26(27,28)29/h3-5,8,11-16,20H,6-7,9-10H2,1-2H3,(H,31,33)(H,32,34)/b17-12-
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n/an/a 30n/an/an/an/a7.425



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
All reagents were purchased from Sigma-Aldrich unless specified. Human and Rat Fatty Acid Amide Hydrolase (FAAH) genes used in assay have been descri...


US Patent US9682953 (2017)


BindingDB Entry DOI: 10.7270/Q2BR8QBH
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM143274
PNG
(US9682953, 2.C-6)
Show SMILES Nc1ncc(cn1)C(=O)NC1CCC(CC1)=Cc1cccc(Oc2ccc(cn2)C(F)(F)F)c1
Show InChI InChI=1S/C24H22F3N5O2/c25-24(26,27)18-6-9-21(29-14-18)34-20-3-1-2-16(11-20)10-15-4-7-19(8-5-15)32-22(33)17-12-30-23(28)31-13-17/h1-3,6,9-14,19H,4-5,7-8H2,(H,32,33)(H2,28,30,31)/b15-10-
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n/an/a 16n/an/an/an/a7.425



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
All reagents were purchased from Sigma-Aldrich unless specified. Human and Rat Fatty Acid Amide Hydrolase (FAAH) genes used in assay have been descri...


US Patent US9682953 (2017)


BindingDB Entry DOI: 10.7270/Q2BR8QBH
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM143280
PNG
(US9682953, 2.E-17)
Show SMILES Cc1nc(Oc2cccc(C=C3CCC(CC3)NC(=O)c3ccc(N)nc3)c2)ccc1C(F)(F)F
Show InChI InChI=1S/C26H25F3N4O2/c1-16-22(26(27,28)29)10-12-24(32-16)35-21-4-2-3-18(14-21)13-17-5-8-20(9-6-17)33-25(34)19-7-11-23(30)31-15-19/h2-4,7,10-15,20H,5-6,8-9H2,1H3,(H2,30,31)(H,33,34)/b17-13-
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n/an/a 27n/an/an/an/a7.425



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
All reagents were purchased from Sigma-Aldrich unless specified. Human and Rat Fatty Acid Amide Hydrolase (FAAH) genes used in assay have been descri...


US Patent US9682953 (2017)


BindingDB Entry DOI: 10.7270/Q2BR8QBH
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM143283
PNG
(US9682953, 2.E-20)
Show SMILES Nc1ccc(cn1)C(=O)NC1CCC(CC1)=Cc1cccc(Oc2ccc(c(Cl)n2)C(F)(F)F)c1
Show InChI InChI=1S/C25H22ClF3N4O2/c26-23-20(25(27,28)29)9-11-22(33-23)35-19-3-1-2-16(13-19)12-15-4-7-18(8-5-15)32-24(34)17-6-10-21(30)31-14-17/h1-3,6,9-14,18H,4-5,7-8H2,(H2,30,31)(H,32,34)/b15-12-
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n/an/a 71n/an/an/an/a7.425



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
All reagents were purchased from Sigma-Aldrich unless specified. Human and Rat Fatty Acid Amide Hydrolase (FAAH) genes used in assay have been descri...


US Patent US9682953 (2017)


BindingDB Entry DOI: 10.7270/Q2BR8QBH
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM143292
PNG
(US9682953, 2.E-28)
Show SMILES Nc1ccc(cn1)C(=O)NC1CCC(CC1)=Cc1cccc(Oc2ccc(c(n2)C#N)C(F)(F)F)c1
Show InChI InChI=1S/C26H22F3N5O2/c27-26(28,29)21-9-11-24(34-22(21)14-30)36-20-3-1-2-17(13-20)12-16-4-7-19(8-5-16)33-25(35)18-6-10-23(31)32-15-18/h1-3,6,9-13,15,19H,4-5,7-8H2,(H2,31,32)(H,33,35)/b16-12-
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n/an/a 75n/an/an/an/a7.425



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
All reagents were purchased from Sigma-Aldrich unless specified. Human and Rat Fatty Acid Amide Hydrolase (FAAH) genes used in assay have been descri...


US Patent US9682953 (2017)


BindingDB Entry DOI: 10.7270/Q2BR8QBH
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM143285
PNG
(US9682953, 2.E-23)
Show SMILES Cc1cc(cnc1N)C(=O)NC1CCC(CC1)=Cc1cccc(Oc2ccc(c(C)n2)C(F)(F)F)c1
Show InChI InChI=1S/C27H27F3N4O2/c1-16-12-20(15-32-25(16)31)26(35)34-21-8-6-18(7-9-21)13-19-4-3-5-22(14-19)36-24-11-10-23(17(2)33-24)27(28,29)30/h3-5,10-15,21H,6-9H2,1-2H3,(H2,31,32)(H,34,35)/b18-13-
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n/an/a 65n/an/an/an/a7.425



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
All reagents were purchased from Sigma-Aldrich unless specified. Human and Rat Fatty Acid Amide Hydrolase (FAAH) genes used in assay have been descri...


US Patent US9682953 (2017)


BindingDB Entry DOI: 10.7270/Q2BR8QBH
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM143284
PNG
(US9682953, 2.E-22)
Show SMILES Cc1nc(Oc2cccc(C=C3CCC(CC3)NC(=O)c3cnc(N)nc3)c2)ccc1C(F)(F)F
Show InChI InChI=1S/C25H24F3N5O2/c1-15-21(25(26,27)28)9-10-22(32-15)35-20-4-2-3-17(12-20)11-16-5-7-19(8-6-16)33-23(34)18-13-30-24(29)31-14-18/h2-4,9-14,19H,5-8H2,1H3,(H,33,34)(H2,29,30,31)/b16-11-
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n/an/a 21n/an/an/an/a7.425



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
All reagents were purchased from Sigma-Aldrich unless specified. Human and Rat Fatty Acid Amide Hydrolase (FAAH) genes used in assay have been descri...


US Patent US9682953 (2017)


BindingDB Entry DOI: 10.7270/Q2BR8QBH
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM143279
PNG
(US9682953, 2.E-16)
Show SMILES Cc1nc(Oc2cccc(C=C3CCC(CC3)NC(=O)c3ccc(N)nc3)c2)ccc1Cl
Show InChI InChI=1S/C25H25ClN4O2/c1-16-22(26)10-12-24(29-16)32-21-4-2-3-18(14-21)13-17-5-8-20(9-6-17)30-25(31)19-7-11-23(27)28-15-19/h2-4,7,10-15,20H,5-6,8-9H2,1H3,(H2,27,28)(H,30,31)/b17-13-
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n/an/a 24n/an/an/an/a7.425



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
All reagents were purchased from Sigma-Aldrich unless specified. Human and Rat Fatty Acid Amide Hydrolase (FAAH) genes used in assay have been descri...


US Patent US9682953 (2017)


BindingDB Entry DOI: 10.7270/Q2BR8QBH
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM143288
PNG
(US9682953, 2.E-25)
Show SMILES Cc1cc(cnc1N)C(=O)NC1CCC(CC1)=Cc1cccc(Oc2ccc(Cl)c(C)n2)c1
Show InChI InChI=1S/C26H27ClN4O2/c1-16-12-20(15-29-25(16)28)26(32)31-21-8-6-18(7-9-21)13-19-4-3-5-22(14-19)33-24-11-10-23(27)17(2)30-24/h3-5,10-15,21H,6-9H2,1-2H3,(H2,28,29)(H,31,32)/b18-13-
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n/an/a 32n/an/an/an/a7.425



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
All reagents were purchased from Sigma-Aldrich unless specified. Human and Rat Fatty Acid Amide Hydrolase (FAAH) genes used in assay have been descri...


US Patent US9682953 (2017)


BindingDB Entry DOI: 10.7270/Q2BR8QBH
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM143291
PNG
(US9682953, 2.E-27)
Show SMILES Cc1nc(Oc2cccc(C=C3CCC(CC3)NC(=O)c3cnc(N)nc3)c2)ccc1Cl
Show InChI InChI=1S/C24H24ClN5O2/c1-15-21(25)9-10-22(29-15)32-20-4-2-3-17(12-20)11-16-5-7-19(8-6-16)30-23(31)18-13-27-24(26)28-14-18/h2-4,9-14,19H,5-8H2,1H3,(H,30,31)(H2,26,27,28)/b16-11-
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n/an/a 17n/an/an/an/a7.425



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
All reagents were purchased from Sigma-Aldrich unless specified. Human and Rat Fatty Acid Amide Hydrolase (FAAH) genes used in assay have been descri...


US Patent US9682953 (2017)


BindingDB Entry DOI: 10.7270/Q2BR8QBH
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM143358
PNG
(US9682953, 20.A-2)
Show SMILES CC(C)c1c2C(N(C(=O)c2nn1CC(=O)NC1CCNCC1)c1cc(Cl)ccc1C)c1ccc(Cl)cc1C
Show InChI InChI=1S/C25H22F3N3O2/c26-25(27,28)20-8-11-23(30-16-20)33-22-5-1-3-18(14-22)13-17-6-9-21(10-7-17)31-24(32)19-4-2-12-29-15-19/h1-5,8,11-16,21H,6-7,9-10H2,(H,31,32)/b17-13-
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n/an/a 13n/an/an/an/a7.425



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
All reagents were purchased from Sigma-Aldrich unless specified. Human and Rat Fatty Acid Amide Hydrolase (FAAH) genes used in assay have been descri...


US Patent US9682953 (2017)


BindingDB Entry DOI: 10.7270/Q2BR8QBH
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM143361
PNG
(US9682953, 20.A-4)
Show SMILES Nc1ccc(cn1)C(=O)NC1CCC(CC1)=Cc1cccc(Oc2ccc(cn2)C(F)(F)F)c1
Show InChI InChI=1S/C25H23F3N4O2/c26-25(27,28)19-7-11-23(31-15-19)34-21-3-1-2-17(13-21)12-16-4-8-20(9-5-16)32-24(33)18-6-10-22(29)30-14-18/h1-3,6-7,10-15,20H,4-5,8-9H2,(H2,29,30)(H,32,33)/b16-12-
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n/an/a 11n/an/an/an/a7.425



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
All reagents were purchased from Sigma-Aldrich unless specified. Human and Rat Fatty Acid Amide Hydrolase (FAAH) genes used in assay have been descri...


US Patent US9682953 (2017)


BindingDB Entry DOI: 10.7270/Q2BR8QBH
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM143366
PNG
(US9682953, 20.A-6)
Show SMILES Cc1cc(cnc1N)C(=O)NC1CCC(CC1)=Cc1cccc(Oc2ccc(cn2)C(F)(F)F)c1
Show InChI InChI=1S/C26H25F3N4O2/c1-16-11-19(14-32-24(16)30)25(34)33-21-8-5-17(6-9-21)12-18-3-2-4-22(13-18)35-23-10-7-20(15-31-23)26(27,28)29/h2-4,7,10-15,21H,5-6,8-9H2,1H3,(H2,30,32)(H,33,34)/b17-12-
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n/an/a 10n/an/an/an/a7.425



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
All reagents were purchased from Sigma-Aldrich unless specified. Human and Rat Fatty Acid Amide Hydrolase (FAAH) genes used in assay have been descri...


US Patent US9682953 (2017)


BindingDB Entry DOI: 10.7270/Q2BR8QBH
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM143368
PNG
(US9682953, 20.A-8)
Show SMILES FC(F)(F)c1n[nH]cc1C(=O)NC1CCC(CC1)=Cc1cccc(Oc2ccc(cn2)C(F)(F)F)c1
Show InChI InChI=1S/C24H20F6N4O2/c25-23(26,27)16-6-9-20(31-12-16)36-18-3-1-2-15(11-18)10-14-4-7-17(8-5-14)33-22(35)19-13-32-34-21(19)24(28,29)30/h1-3,6,9-13,17H,4-5,7-8H2,(H,32,34)(H,33,35)/b14-10-
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n/an/a 30n/an/an/an/a7.425



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
All reagents were purchased from Sigma-Aldrich unless specified. Human and Rat Fatty Acid Amide Hydrolase (FAAH) genes used in assay have been descri...


US Patent US9682953 (2017)


BindingDB Entry DOI: 10.7270/Q2BR8QBH
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM143373
PNG
(US9682953, 20.A-10 | US9682953, 20.A-9)
Show SMILES Nc1ncc(cn1)C(=O)NC1CCC(CC1)=Cc1cccc(Oc2ccc(cn2)C(F)(F)F)c1
Show InChI InChI=1S/C24H22F3N5O2/c25-24(26,27)18-6-9-21(29-14-18)34-20-3-1-2-16(11-20)10-15-4-7-19(8-5-15)32-22(33)17-12-30-23(28)31-13-17/h1-3,6,9-14,19H,4-5,7-8H2,(H,32,33)(H2,28,30,31)/b15-10-
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n/an/a 7n/an/an/an/a7.425



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
All reagents were purchased from Sigma-Aldrich unless specified. Human and Rat Fatty Acid Amide Hydrolase (FAAH) genes used in assay have been descri...


US Patent US9682953 (2017)


BindingDB Entry DOI: 10.7270/Q2BR8QBH
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM143375
PNG
(US9682953, 20.A-11 | US9682953, 20.A-12)
Show SMILES FC(F)(F)c1ccc(Oc2cccc(C=C3CCC(CC3)NC(=O)c3cn[nH]c3)c2)nc1
Show InChI InChI=1S/C23H21F3N4O2/c24-23(25,26)18-6-9-21(27-14-18)32-20-3-1-2-16(11-20)10-15-4-7-19(8-5-15)30-22(31)17-12-28-29-13-17/h1-3,6,9-14,19H,4-5,7-8H2,(H,28,29)(H,30,31)/b15-10-
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n/an/a 36n/an/an/an/a7.425



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
All reagents were purchased from Sigma-Aldrich unless specified. Human and Rat Fatty Acid Amide Hydrolase (FAAH) genes used in assay have been descri...


US Patent US9682953 (2017)


BindingDB Entry DOI: 10.7270/Q2BR8QBH
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM143388
PNG
(US9682953, 20.A-13)
Show SMILES FC(F)(F)c1ccc(Oc2cccc(C=C3CCC(CC3)NC(=O)c3cnc4[nH]ccc4c3)c2)nc1
Show InChI InChI=1S/C27H23F3N4O2/c28-27(29,30)21-6-9-24(32-16-21)36-23-3-1-2-18(13-23)12-17-4-7-22(8-5-17)34-26(35)20-14-19-10-11-31-25(19)33-15-20/h1-3,6,9-16,22H,4-5,7-8H2,(H,31,33)(H,34,35)/b17-12-
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n/an/a 407n/an/an/an/a7.425



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
All reagents were purchased from Sigma-Aldrich unless specified. Human and Rat Fatty Acid Amide Hydrolase (FAAH) genes used in assay have been descri...


US Patent US9682953 (2017)


BindingDB Entry DOI: 10.7270/Q2BR8QBH
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM143391
PNG
(US9682953, 20.A-14)
Show SMILES FC(F)(F)c1ccc(Oc2cccc(C=C3CCC(CC3)NC(=O)c3cnc4[nH]ccc4c3)c2)nc1
Show InChI InChI=1S/C27H23F3N4O2/c28-27(29,30)21-6-9-24(32-16-21)36-23-3-1-2-18(13-23)12-17-4-7-22(8-5-17)34-26(35)20-14-19-10-11-31-25(19)33-15-20/h1-3,6,9-16,22H,4-5,7-8H2,(H,31,33)(H,34,35)/b17-12-
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n/an/a 8.60n/an/an/an/a7.425



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
All reagents were purchased from Sigma-Aldrich unless specified. Human and Rat Fatty Acid Amide Hydrolase (FAAH) genes used in assay have been descri...


US Patent US9682953 (2017)


BindingDB Entry DOI: 10.7270/Q2BR8QBH
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM143402
PNG
(US9682953, 20.A-15 | US9682953, 20.A-16)
Show SMILES FC(F)(F)c1ccc(Oc2cccc(C=C3CCC(CC3)NC(=O)c3cccnn3)c2)nc1
Show InChI InChI=1S/C24H21F3N4O2/c25-24(26,27)18-8-11-22(28-15-18)33-20-4-1-3-17(14-20)13-16-6-9-19(10-7-16)30-23(32)21-5-2-12-29-31-21/h1-5,8,11-15,19H,6-7,9-10H2,(H,30,32)/b16-13-
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n/an/a 408n/an/an/an/a7.425



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
All reagents were purchased from Sigma-Aldrich unless specified. Human and Rat Fatty Acid Amide Hydrolase (FAAH) genes used in assay have been descri...


US Patent US9682953 (2017)


BindingDB Entry DOI: 10.7270/Q2BR8QBH
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM143402
PNG
(US9682953, 20.A-15 | US9682953, 20.A-16)
Show SMILES FC(F)(F)c1ccc(Oc2cccc(C=C3CCC(CC3)NC(=O)c3cccnn3)c2)nc1
Show InChI InChI=1S/C24H21F3N4O2/c25-24(26,27)18-8-11-22(28-15-18)33-20-4-1-3-17(14-20)13-16-6-9-19(10-7-16)30-23(32)21-5-2-12-29-31-21/h1-5,8,11-15,19H,6-7,9-10H2,(H,30,32)/b16-13-
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n/an/a 115n/an/an/an/a7.425



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
All reagents were purchased from Sigma-Aldrich unless specified. Human and Rat Fatty Acid Amide Hydrolase (FAAH) genes used in assay have been descri...


US Patent US9682953 (2017)


BindingDB Entry DOI: 10.7270/Q2BR8QBH
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM143448
PNG
(US9682953, 20.A-18)
Show SMILES COc1ccccc1-n1nc2C(=O)N(c3ccc(F)c(Cl)c3)C(CC3CO3)(c2c1C(C)C)c1ccc(Cl)cc1
Show InChI InChI=1S/C28H24F3N3O2/c29-28(30,31)20-10-13-26(33-16-20)36-22-5-3-4-19(15-22)14-18-8-11-21(12-9-18)34-27(35)24-17-32-25-7-2-1-6-23(24)25/h1-7,10,13-17,21,32H,8-9,11-12H2,(H,34,35)/b18-14-
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n/an/a 35n/an/an/an/a7.425



ADVINUS THERAPEUTICS LIMITED

US Patent


Assay Description
All reagents were purchased from Sigma-Aldrich unless specified. Human and Rat Fatty Acid Amide Hydrolase (FAAH) genes used in assay have been descri...


US Patent US9682953 (2017)


BindingDB Entry DOI: 10.7270/Q2BR8QBH
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50386424
PNG
(CHEMBL2047528)
Show SMILES CN(CCCOc1ccc2ccc(=O)oc2c1)Cc1cccc(OC(=O)NCCCCCc2ccccc2)c1
Show InChI InChI=1S/C32H36N2O5/c1-34(20-9-21-37-28-17-15-27-16-18-31(35)39-30(27)23-28)24-26-13-8-14-29(22-26)38-32(36)33-19-7-3-6-12-25-10-4-2-5-11-25/h2,4-5,8,10-11,13-18,22-23H,3,6-7,9,12,19-21,24H2,1H3,(H,33,36)
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Article
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n/an/a 4.10E+3n/an/an/an/a7.4n/a



Alma Mater Studiorum University of Bologna

Curated by ChEMBL


Assay Description
Inhibition of FAAH in rat brain membrane at pH 7.4 using N-arachidonoyl-[14C]-ethanolamine as substrate preincubated for 10 mins followed by substrat...


J Med Chem 59: 6387-406 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00609
BindingDB Entry DOI: 10.7270/Q21G0P6Q
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM26739
PNG
(3-(3-carbamoylphenyl)phenyl N-cyclohexylcarbamate ...)
Show SMILES NC(=O)c1cccc(c1)-c1cccc(OC(=O)NC2CCCCC2)c1
Show InChI InChI=1S/C20H22N2O3/c21-19(23)16-8-4-6-14(12-16)15-7-5-11-18(13-15)25-20(24)22-17-9-2-1-3-10-17/h4-8,11-13,17H,1-3,9-10H2,(H2,21,23)(H,22,24)
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n/an/a 141n/an/an/an/a7.4n/a



Alma Mater Studiorum University of Bologna

Curated by ChEMBL


Assay Description
Inhibition of FAAH in rat brain membrane at pH 7.4 using N-arachidonoyl-[14C]-ethanolamine as substrate preincubated for 10 mins followed by substrat...


J Med Chem 59: 6387-406 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00609
BindingDB Entry DOI: 10.7270/Q21G0P6Q
More data for this
Ligand-Target Pair
Anandamide amidohydrolase


(Rattus norvegicus (rat))
BDBM50009859
PNG
((+-)-2-(p-isobutylphenyl)propionic acid | (+-)-alp...)
Show SMILES CC(C)Cc1ccc(cc1)C(C)C(O)=O
Show InChI InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)
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n/an/a 2.40E+5n/an/an/an/a7.4n/a



University of Cagliari

Curated by ChEMBL


Assay Description
Inhibition of FAAH-mediated [3H]AEA hydrolysis in rat brain homogenate at pH 7.4 by liquid scintillation spectroscopy


J Med Chem 53: 2286-98 (2010)


Article DOI: 10.1021/jm901891p
BindingDB Entry DOI: 10.7270/Q2833S4K
More data for this
Ligand-Target Pair
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